Tesis sobre el tema "Glucose reaction"
Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros
Consulte los 50 mejores tesis para su investigación sobre el tema "Glucose reaction".
Junto a cada fuente en la lista de referencias hay un botón "Agregar a la bibliografía". Pulsa este botón, y generaremos automáticamente la referencia bibliográfica para la obra elegida en el estilo de cita que necesites: APA, MLA, Harvard, Vancouver, Chicago, etc.
También puede descargar el texto completo de la publicación académica en formato pdf y leer en línea su resumen siempre que esté disponible en los metadatos.
Explore tesis sobre una amplia variedad de disciplinas y organice su bibliografía correctamente.
Bersuder, Philippe. "Investigation of Maillard reaction products as antioxidants". Thesis, University of Lincoln, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319773.
Texto completoGe, Xue. "Covalent catalysis in the UDP-glucose dehydrogenase reaction". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0019/NQ48638.pdf.
Texto completoDAI, ZHENYU. "PROTEIN CROSSLINKING BY THE MAILLARD REACTION WITH ASCORBIC ACID AND GLUCOSE". Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1184176746.
Texto completoMshayisa, Vusi Vincent. "Antioxidant effects of Maillard reaction products (MRPs) derived from glucose-casein model systems". Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2505.
Texto completoThe Maillard reaction (MR) involves the condensation reaction between amino acids or proteins with reducing sugars, which occurs commonly in food processing and storage. Maillard reaction products (MRPs) were prepared from glucose-casein model system at pH 8, heated at 60, 75 and 90°C for 6, 12 and 24 h, respectively. Browning intensity (BI) of MRPs, as monitored by absorbance at 420 nm increased with an increase in reaction temperature. The reducing power (RP) of MRPs increased (p < 0.05) as the reaction time increased at 60 and 75°C, while at 90°C an increase in RP was observed from 6 to 12 h and thereafter a slight decrease was observed up to 24 h. The 2,2-Azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) radical scavenging activity (ABTS-RS) and Peroxyl radical scavenging (PRS) activity of glucose-casein MRPs produced at 90°C decreased as the reaction time increased. In this study, the ferrous chelation activity of MRPs was higher than that of tert-butylhydroquinone (TBHQ) (0.02%) and Trolox (1 mM), respectively. Moreover, the 1, 1-diphenyl-2-picryl-hydrazil radical scavenging (DPPH-RS) of MRPs increased (p < 0.05) as the reaction time increased irrespective of the heating temperature. The primary and secondary lipid oxidation products were measured using the Peroxide value (PV) and Thiobarbituric acid reactive substance (TBARs) assay in sunflower oil-in-water emulsion, respectively. MRPs derived at 90°C for 12 h had the lowest peroxide value, while the TBARs inhibitory by MRPs ranged from 39.05 – 88.66%. Glucose-casein MRPs displayed superior antioxidant activity than TBHQ (0.02%) and Trolox (1 mM), respectively, as measured by the TBARs assay. The differential scanning calorimetry (DSC) and Rancimat techniques set at 110°C were used to evaluate the oxidative stability the lipid-rich media containing MRPs. At the same temperature program, DSC gave significantly lower reduction times than the Rancimat. Furosine (N-ε-Fructosyl-lysine) and Pyrraline (2-amino-6-(2-formyl-5-hydroxymethyl-1-pyrrolyl)-hexanoic acid) were determined using high pressure liquid chromatography to evaluate the extent of the MR. Furosine concentration of glucose-casein MRPs ranged between 0.44 – 1.075 mg.L-1 in MRPs derived at 60°C, while at 75°C an increase as function of time was observed. MRPs derived at 60 and 75°C exhibited a varied concentration of pyrraline as the reaction time increased with higher temperatures resulted in higher concentrations (0.39 mg.L-1). The results of this study clearly indicated that MRPs possess antioxidant activity and can be used as natural antioxidants in the food industry.
Topin, Agnès. "Contribution à l'étude de quelques interactions acides aminés-glucose dans des solutions de nutrition parentérale". Paris 5, 1993. http://www.theses.fr/1993PA05P029.
Texto completoBotero, Carrizosa Sara C. "Synthesis, Characterization, and Properties of Graphene-Based Hybrids with Cobalt Oxides for Electrochemical Energy Storage and Electrocatalytic Glucose Sensing". TopSCHOLAR®, 2017. http://digitalcommons.wku.edu/theses/1941.
Texto completoEssis-Yei, L. Hortense. "Oxydation electrocatalytique du glucose sur le platine et l'or en milieu aqueux". Poitiers, 1987. http://www.theses.fr/1987POIT2277.
Texto completoLee, Jeehyun. "Analyse et modélisation de la réactivité au cours de la cuisson d’un produit modèle mimétique d’un produit céréalier type génoise". Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS606.
Texto completoIn the context of developing tools to control the formation, during food processing, of newly-formed compounds having positive or negative impact on food quality and safety, this work aimed to understand and to describe the Maillard reaction and caramelization during the baking of a model product and to propose a modelling approach for predicting kinetics coupled with heat and mass transfers. An inert model product structurally imitative of a sponge cake was used. Thus, it was possible to specifically induce reactions by adding glucose alone for the G formula and with leucine for the G+L formula. The development of quantitative methods for twenty reaction markers (precursors, intermediates and products) was carried out to be able to acquire the kinetic data. The accelerating effect of the temperature and the absence of effect of the level of convection on the formation and the degradation of most of the markers were highlighted and quantified by kinetic results. The addition of leucine activated the Maillard reaction pathways including the Strecker degradation and the catalytic effect of leucine could be observed relatively to the caramelization routes exclusively present in the reaction model (G). Thanks to the experimental data acquired, a model of prediction of temperature and moisture content was developped, and then coupled to the kinetic model. The simultaneous identification of a large number of parameters over a wide range of values need to be pursued. However, two proofs of concept could be conducted on the caramelization model (G formula), one on all the markers for a single baking condition, and the other on glucose degradation for all baking conditions. They are encouraging for further modeling work
Krishna, Rahul. "Transition metal doped graphene for energy and electrical applications". Doctoral thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/16543.
Texto completoIn the view of rapid progress in the fabrication of nanoscale energy storage and electronic devices, graphene is a subject of great interest. As a truly two dimensional (2D) system, graphene possess extraordinary properties of high conductivity, high carrier mobility, large surface area (>2600 m2/g), flexibility, and chemical stability which are favourable for energy applications. Synthesis of high quality graphene still remains as a major challenge in graphene research. Various methods including mechanical exfoliation, thermal exfoliation and thermal chemical vapour deposition (CVD) methods are used for the production of high quality graphene. However, mass production of graphene is possible only by chemical exfoliation of graphite under strong oxidizing agents. This thesis deals with the state of the art mass production of reduced graphene oxide (RGO) using graphene oxide (GO) as the intermediate agent. One of the exciting ideas about graphene oxide is that, due to the functional groups attached, it could act as a laboratory for various catalytic reactions and led to the fabrication of novel devices. Transition metals were used to aid the reaction and to achieve desired novel properties. By catalytic reactions, high quality nanoparticles (NPs) such as Ni, Co, Pd Ag, Cu, NixB, CoxB and SiO2 were synthesized and anchored on graphene sheet for energy applications. Particularly, for hydrogen storage a nanocomposite catalyst containing palladium@ nickel boride–silica and reduced graphene oxide (Pd@NixB–SiO2/RGO, abbreviated as Pd@NSG) was successfully fabricated. The H2 adsorption experiment directly reveals the spillover effect on the Pd@NSG nanocomposite and its enhanced H2 uptake capacity (0.7 wt.%) compared to SiO2/RGO (0.05 wt.%) under 50 bar hydrogen pressure at RT. On the basis of results a detailed mechanism of hydrogen spillover is established that exhibited the facile H2 dissociation on the Pd activator (active sites) and subsequent transportation of hydrogen atoms on receptor sites. Similarly, highly active and cost effective nanocomposite CoxB@Ni/RGO was also synthesized for hydrogen production through electrochemical oxidation of ethanol in alkaline medium under catalysis reaction. The electrochemical behavior of nanocomposite was evaluated by cyclic voltammetry (CV) technique. The catalytic activity of nanocomposite was evaluated continuously for 50 cyclic run; amazingly, results shows that the increase of current density after 50 cycle run suggests the self-cleaning process and robustness of catalyst system. For energy application, graphene based nanocomposite has also been employed for catalysis reduction of 4-nitrophenol (4-NP) organic pollutant. For this work, a wide range of graphene nanocomposite catalysts has been synthesized and the effort was to reduce reaction time and cost of nanocatalyst system. Finally, graphene based nanocomposite (Ni/RGO) is used for electrical and electronics applications also, to fabricate the memristor devices and glucose biosensor. A wide range of characterization techniques mainly X-ray diffraction (XRD), fourier transform infra-red (FTIR), Raman, X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), current vs. voltage (I-V) measurements, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were employed for analysis of transition metals doped graphene nanocomposites for various kind of energy applications.
Do ponto de vista do rápido progresso na fabricação de dispositivos eletrónicos de armazenamento de energia em nanoescala, o grafeno é um assunto de grande interesse. Como um sistema verdadeiramente bidimensional (2D), o grafeno possui propriedades extraordinárias de alta condutividade, grande mobilidade de portadores de carga, grande área de superfície (> 2600 m2 / g), flexibilidade e estabilidade química, que são favoráveis para aplicações energéticas. A síntese de grafeno de alta qualidade ainda permanece como um grande desafio na investigação no grafeno. Vários métodos, incluindo esfoliação mecânica, térmica e deposição química por vapor (CVD) são métodos utilizados para a produção de grafeno de alta qualidade. No entanto, a produção em massa de grafeno só é possível por esfoliação química de grafite sob agentes oxidantes fortes. Esta tese lida com o estado da arte de produção de óxido de grafeno reduzido (RGO) em massa usando óxido de grafeno (GO) como agente intermediário. Uma das ideias empolgantes em relação ao óxido de grafeno é a de que, devido aos grupos funcionais ligados, ele poderia actuar como um laboratório para várias reacções catalíticas e conduzir à fabricação de novos dispositivos. Os metais de transição foram usados para auxiliar a reacção e para atingir as novas propriedades desejadas. Por reações catalíticas, as nanopartículas de alta qualidade (NPs), tais como Ni, Co, Pd, Ag, Cu, NixB, CoxB e SiO2 foram sintetizadas e ancoradas numa folha de grafeno para aplicações de energia. Particularmente, para o armazenamento de hidrogénio um catalisador nanocompósito contendo paládio@níquel boreto-sílica e óxido de grafeno reduzido (Pd @ NixB-SiO2 / RGO, abreviado como Pd @ NSG) foi fabricado com sucesso. A experiência de adsorção de H2 revela diretamente o efeito de transbordo (spillover) no nanocompósito Pd @ NSG e sua maior capacidade de absorção de H2 (0,7 wt.%) em comparação com SiO2 / RGO (0,05 wt.%), sob uma pressão de 50 bar de hidrogénio à temperatura ambiente. Com base nos resultados um mecanismo detalhado de transbordo de hidrogénio é estabelecido que exibe a dissociação fácil de H2 no ativador Pd (centros activos) e o transporte subsequente de átomos de hidrogénio em locais receptores. Da mesma forma, o altamente ativo e rentável nanocompósito CoxB @ Ni / RGO foi também sintetizado para produção de hidrogénio através de oxidação eletroquímica de etanol em meio alcalino sob catálise de reacção. O comportamento eletroquímico do nanocompósito foi avaliado pela técnica de voltametria cíclica (CV). A atividade catalítica do nanocompósito foi avaliada continuamente por 50 ciclos; surpreendentemente, os resultados mostram que o aumento da densidade de corrente após 50 ciclos sugere o processo de auto-limpeza e robustez do sistema de catalisador. Para a aplicação de energia, o nanocompósito baseado em grafeno também tem sido usado para a redução catalítica de 4- nitrofenol (4- NP ) poluente orgânico . Para este trabalho, uma ampla gama de catalisadores de grafeno nanocompósito foi sintetizada e o esforço foi o de reduzir o tempo de reacção e o custo do sistema nanocatalisador. Finalmente, o nanocompósito baseado em grafeno (Ni / RGO ) é usado para aplicações elétricas e eletrónicas, e também para fabricar os dispositivos memresistivos e biossensores de glicose. Uma vasta gama de técnicas de caracterização, principalmente difração de raios X (XRD), espectroscopia de infravermelhos (FTIR, Raman, espectroscopia de fotoeletrões de raios-X (XPS), microscopia eletrónica de varrimento (SEM), microscopia eletrónica de transmissão (TEM), medições de corrente vs. tensão (I-V), voltametria cíclica (CV) e espectroscopia de impedância eletroquímica (EIS), foram usadas para análise de nanocompósitos de grafeno dopados com metais de transição para vários tipos de aplicações de energia.
Leygue, Jean-Philippe. "Coproduction d'acide gluconique, de fructose et de fructooligosides par Aspergillus niger sur saccharose". Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37615198m.
Texto completoMELI, Alessandro. "DEEP EUTECTIC SOLVENTS E LIQUIDI IONICI: SOLVENTI PER LO SVILUPPO DI PROCESSI ECO-COMPATIBILI". Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/395244.
Texto completoDevaiah, Shivakumar P., Cheng Zhang y Cecelia A. McIntosh. "Structure and Functional Analysis of Glucosyltransferase from Citrus paradisi". Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/344.
Texto completoAdidou, Ouissam. "Ligands dérivés de saccharides et, ou supportés par un bras poly(éthylène) glycol : synthèse et applications en catalyse organométallique". Thesis, Lyon 1, 2009. http://www.theses.fr/2009LYO10171.
Texto completoLigands derived from saccharides and, or supported on poly(ethylene) glycol arm: synthesis and applications in organometallic catalysis. The synthesis of two types of ligands has been investigated. The first family of ligands has been the preparation of new ligands derived from D-glucosamine or D-glucose, which have been tested in the allylic substitution of Tsuji-Trost in homogeneous phase. The second one has een the preparation of ligand supported on poly(ethylene) glycol arm and derived from D-glucosamine or di-(2- pyridyl)methylamine. These last hydrosoluble ligands have been tested in two Pd-catalyzed reactions in aqueous phase: the allylic substitution of Tsuji-Trost and the cross-coupling Suzuki-Miyaura reaction, respectively
Hanover, Karl Frederic. "The hydrogenation of glucose with Raney-nickel : an examination of the side reactions /". Thesis, Connect to this title online; UW restricted, 1987. http://hdl.handle.net/1773/5514.
Texto completoGoran, Benedeković. "Enantiodivergentna totalna sinteza odabranih stiril laktona i preliminarno ispitivanje njihove citotoksičnosti". Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2012. http://dx.doi.org/10.2298/NS20121011BENEDEKOVIC.
Texto completoEnantiodivergent total syntheses of both (+)- and (−)-enantiomers of goniofufurone, 7-epi-goniofufurone and crassalactone C have been accomplished starting from D-glucose. The key steps of the synthe-sis of 7-epi-(+)-goniofufurone were a stereo-selective addition of phenyl magnesium bromide to a protected dialdose, followed by a stereospecific furano-lactone ring formation by condensation of a partially protected lactole with Meldrum’s acid. The synthesis of (+)-goniofufurone and (+)-crassalactone C required a configurational inversion at C-5 in the common intermediate that was efficiently achieved under the standard Mitsunobu conditions, or alternatively through a sequential oxidation of the benzylic hydroxyl group followed by a stereo-selective reduction with borohydride. A similar approach was applied to the synthesis of the unnatural enantiomers of goniofufurone, 7-epi-goniofufurone and crassalactone C, two novel, conformationally constrained analogues of both (+)- and (−)-goniofufurone (oxetanes 34 and ent-34). as well as the corresponding 7-deoxygenated derivatives (31 and ent-31). We have also developed the first total synthesis of (+)-crassalactone B (2) and an alternative synthesis of (+)-crassalactone C (3) starting from D-glucose. Finally, the synthesized styryl-lactones were evaluated for their antiproliferative activity against a panel of human tumor cell lines.
Sathanantham, Preethi, Shiva K. Devaiah y Cecelia A. McIntosh. "Structure-Function Analysis of Grapefruit Glucosyltransferase Protein – Identification of Key Amino Acid Residues for its Rigid Substrate Specificity". Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/352.
Texto completoOlsson, Rickard. "Surface reactions on mineral particles controlling the hydrolysis of glucose phosphates". Doctoral thesis, Umeå universitet, Kemiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46578.
Texto completoKeyhani, Anahita. "PYGCMS investigation of the mechanism of Maillard reaction using isotopically enriched amino-acids and d-glucoses". Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42066.
Texto completoPhenylalanine Amadori product and different model systems containing phenylalanine and different reducing sugars were studied. Ribbon pyrolysis was used to study the effect of temperature (150, 200, 250$ sp circ$C) on the efficiency of formation of initial pyrolysis products from phenylalanine and Amadori phenylalanine. Quartz tube pyrolysis was used at 250$ sp circ$C to enhance the secondary reactions. These studies revealed the formation of pyridine and naphthalene derivatives such as 3,5-diphenylpyridine, 1(2)-naphthaleneamine, N-methyl-1(2)-aminonaphthalene, 1-aminoanthracene, 2$ sp prime$-phenyl-pyrrolo (4,5-A) dihydronaphthalene, 1(2)-(N-phenethyl)napthaleneamine and 1(2)-(N-phenethyl-N-methyl)naphthaleneamine.
Model studies using scD- ($ sp{13}$C) glucoses and a series of dicarbonyl compounds with labeled ($ sp{15}$N/$ sp{13}$C) glycines and ($ sp{15}$N/$ sp{13}$C) alanines identified a new chemical transformation of $ alpha$-dicarbonyls, that lead to the addition of alkyl groups from the amino acid to the $ alpha$-dicarbonyl compounds, instead of the amino group as in the case of the Strecker type interaction between the two reactants. Thus, glyoxal and pyruvaldehyde can be transformed into pyruvaldehyde and 2,3-butanedione respectively, by glycine and 2-ketobutanal and 2,3-pentanedione respectively, by scL-alanine. The labeled glycine model studies indicated that methyl substituted pyrazines and pyrazinones formed in the model systems, have a common intermediate. Two pathways of pyrazinone formation were distinguished based on the labeling experiments, one involving the reaction of three moles of glycine and the other the interaction of the dipeptide glycylglycine with an $ alpha$-dicarbonyl compound.
A major product of the reaction of scD-glucose with excess glycine was detected by Py/GC/MS analysis and subsequently synthesized and isolated using focused microwave irradiation at atmospheric pressure conditions. Spectroscopic analysis by NMR, FTIR, MS and UV in conjunction with labeling studies have indicated the unknown compound to be 5-hydroxy-1,3-dimethyl-2 (1H) -quinoxalinone. The labeling studies indicated the incorporation of ten carbon atoms (six from sugar, one C-1 atom of glycine, and three C-2 atoms of glycine) and two nitrogens.
scL-Serine was found to be a unique amino acid generating in the absence of sugar a variety of heterocyclic compounds. Under pyrolytic conditions scL-serine can be viewed as a potential mixture of glycine, alanine, serine, formaldehyde and dicarbonyl compounds.
Model studies with scL-methionine provided evidence that methional (Strecker aldehyde) generated under Quartz tube pyrolysis undergoes secondary reactions with amino compounds generating 1,3-thiazines or 3-substituted pyridine in a similar fashion to that of scL-phenylalanine systems where 3-substituted pyridines were also identified. (Abstract shortened by UMI.)
Shizas, Ioannis. "Start-up of a laboratory-scale anaerobic sequencing batch reactor treating glucose". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0015/MQ49734.pdf.
Texto completoChretien, Chloé. "Un nouvel acteur dans la détection hypothalamique du glucose : les canaux Transient Receptor Potential Canonical (TRPC)". Thesis, Dijon, 2015. http://www.theses.fr/2015DIJOS027/document.
Texto completoHyperglycemia is detected and integrated by the mediobasal hypothalamus (MBH) which, in turn, inhibits food intake and triggers insulin secretion. The MBH houses specialized glucose-sensitive (GS) neurons, which directly or indirectly modulate their electrical activity in response to changes in glucose level. In a first study, we hypothesized that indirect detection of glucose by MBH GS neurons involves the secretion of endozepine by astrocytes, a gliotransmitter known to inhibit food intake in response to hyperglycemia. The present work shows that endozepines selectively activate anorexigenic MBH pro-opiomelanotortine (POMC) neurons. In the second study, we show that the direct detection of increased glucose level involves hypothalamic glucose-excited (HGE) neurons. Using pharmacological and genetic approaches, we demonstrate that the redox-sensitive Transient Receptor Potential Canonical 3 et 4 (TRPC3/4) channels are involved in MBH HGE response to glucose in vitro and increased insulin secretion and decreased food intake in response to cerebral hyperglycemia in vivo. We also obtained evidences that MBH TRPC3 channel is a critical new player for energy homeostasis. This thesis work identifies two new mechanisms involved in hypothalamic detection of hyperglycemia: the first based on the involvement of TRPC3/4 channels in HGE neurons and the second highlighting the astroglial endozepines as a relay of the “glucose” signal to POMC neurons
MIRIBEL, VERONIQUE. "Synthese d'anticorps bispecifiques par voie chimique. Application au couplage de deux reactions enzymatiques : glucose oxydase/peroxydase". Compiègne, 1992. http://www.theses.fr/1992COMP0481.
Texto completoMele, Stephen Louis. "Effects of glucose and flow on reactive oxygen species in brain artery endothelial cells". Thesis, State University of New York at Buffalo, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1594755.
Texto completoEndothelial cells play a vital role in the normal physiology of the vasculature. The cerebrovascular region is highly populated by endothelial cells with distinct morphology and functions. However, endothelial cells are also a vital region in the pathophysiology of the vasculature, such as aneurysm formation, due to reactive oxygen species (ROS) production. To study the effects of glucose and flow on ROS production in brain arterial endothelial cells, ROS production was measured. This thesis is divided into three parts: glucose effect on ROS, flow effect on ROS, and glucose effect on flow-induced ROS. Previous endothelial cultures were provided by Joeseph Moran-Guiati and Jason Kushner. The effect of high glucose on static endothelial cells was shown to increase ROS production as compared to the effect of normal glucose. Under chronic treatment of endothelial cells with high flow, ROS production was significantly greater that in endothelial cells under chronic treatment of normal flow. High glucose was shown to exacerbate the high flow response. These studies provide insight to a possible connection between intracranial aneurysm formation and a major risk factor, Diabetes Mellitus.
AGUIARI, Paola. "High Glucose Induces Adipogenic Differentiation of Muscle-Derived Stem Cells". Doctoral thesis, Università degli studi di Ferrara, 2009. http://hdl.handle.net/11392/2388681.
Texto completoSaiepour, Daniel. "Glucose and insulin modulate phagocytosis and production of reactive oxygen metabolites in human neutrophil granulocytes". Doctoral thesis, Umeå : Integrativ medicinsk biologi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-683.
Texto completoHooper, Stephanie Elaine. "Development of an Ionically-Assembled On-Column Enzyme Reactor for Capillary Electrophoresis". Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/28190.
Texto completoPh. D.
Fujita, Yoshihito. "Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice". Kyoto University, 2010. http://hdl.handle.net/2433/123334.
Texto completoKeyhani, Anahita. "Py/GC/MS investigation of the mechanism of Maillard reaction using isotopically enriched amino acids and D-glucoses". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0025/NQ30308.pdf.
Texto completoModenbach, Alicia. "Sodium hydroxide pretreatment of corn stover and subsequent enzymatic hydrolysis: An investigation of yields, kinetic modeling and glucose recovery". UKnowledge, 2013. http://uknowledge.uky.edu/bae_etds/17.
Texto completoCavalcante, Isadora Pontes. "Correlação da expressão de GLUT1, HK1, HK2 e HK3 com alta captação de 18/F-FDG em hiperplasia macronodular adrenal primária". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-12012015-125308/.
Texto completoIntroduction: Primary macronodular adrenal hyperplasia (PMAH) is a rare cause of Cushing\'s syndrome, characterized by functioning adrenal macronodules and increased cortisol production. Recently, integrated 18F-FDG-PET/CT examination revealed an increased 18F-FDG uptake in patients with PMAH. However, it is still unclear the mechanism by which PMAH would present with a high 18F-FDG uptake in PET/CT. Objectives: The aim of this study was to investigate whether GLUT1, HK1, HK2 and/or HK3 expression would account for the high18F-FDG uptake in PMAH and compare these expressions with ACA and ACC adrenal tisuue. Methods: 12 patients undergoing adrenalectomy for PMAH with previous 18F-FDG-PET/CT. 18F-FDG uptake was quantified as the maximum standardized uptake value (maxSUV). mRNA expression was investigated through quantitative RT-PCR and protein expression was investigated using immunohistochemical studies. PMAH gene and protein expression were compared to 15 patients with ACA and 10 with ACC. Correlations were performed through Pearson\'s correlation coefficient test and comparisons through Kruskal-Wallis test, followed by Dunn adjust. Statistical significance was considered when p < 0.05. Results: All patients with PMAH presented with high 18F-FDG uptake, the range of SUVmax in these patients varied from 3.3 to 8.9 and the nodule sizes varied from 3.5 to 15 cm. There was a strong positive correlation between the nodule size and 18F-FDG uptake. However, no correlation could be established between gene and protein expression of GLUT1, HK1, HK2 and HK3 and 18F-FDG uptake. SLC2A1 and HK2 expression was significantly higher in patients with CCA than in patients with AAC and PMAH. Conclusions: Increased 18F-FDG uptake in PMAH does not arise from the overexpression of GLUT1, HK1, HK2 or HK3. Further investigation is required to elucidate the glycolytic pathway involved in glucose metabolism in PMAH
Khouri, Tarek Zaki. "The effects of glucose and fatty acids on enhanced biological phosphorus removal using a sequencing batch reactor". Master's thesis, University of Central Florida, 1996. http://digital.library.ucf.edu/cdm/ref/collection/RTD/id/16679.
Texto completoTwo anaerobic/aerobic sequencing batch reactors (SBRs) were used to evaluate enhanced biological phosphorus removal (EBPR). The first SBR, designated the Glucose SBR, was run for a period of four months. It received a synthetic wastewater plus glucose as a supplemental carbon source. The second SBR, the Isovaleric SBR, was run for three months. During the first month, isovaleric acid was its supplemental carbon source while for the remaining time period, no supplemental carbon source was added to the feed. Steady-state data from the SBR receiving isovalerate yielded the highest phosphorus (P) removals observed during the study, with a mixed liquor volatile suspended solid (MLVSS) P content of 7.2%. The next highest removals were observed when prefermented glucose was received, which yielded a MLVSS P content of 6.4%. The lowest removals were observed when no supplemental carbon source was added to the SBR influent, with at 4.4% MLVSS P content. Batch experiments were also conducted to quantify the effect of EBPR of glucose and the volatile fatty acids (VFAs) acetic acid, propionic acid, valeric acid, and isovaleric acid. Compounds giving the largest anaerobic P release ultimately yielded the lowest effluent P concentrations. At 0.80 mmoles/l, isovaleric acid resulted in anaerobic P released 9.5 mg/l greater than an equal amount of glucose or propionic acid, but ultimately gave effluent P values roughly 4 mg/l lower than either. Ratios of aerobic P uptake/anaerobic P release were found to be roughly equal for all the VFAs when the VFAs were compared on a molar basis. Propionic acid had aerobic P uptake/anaerobic P release ratios similar to the other VFAs. It also behaved the same as all the other VFAs with respect to the effect of concentrations added to the batch experiment; however, the magnitude of its removal was significantly lower than all the other substrates. Glucose, on the other hand, behaved differently from all the VFAs. Glucose aerobic P uptake/anaerobic P release ratios varied with concentration, which was not the case for the others substrates. Also, glucose P net removals decreased at concentrations higher than 0.60 mmoles/l. Glucose also resulted in net P removals roughly 2mg/l higher than propionic acid, but ultimately gave lower net P removal than isovaleric, valeric and acetic acids.
M.S.;
Civil and Environmental Engineering
Engineering;
Environmental Engineering Sciences
111 p.
xi, 111 leaves, bound : ill. ; 28 cm.
Löbner, Jürgen. "N-Terminale Glykierung von Proteinen in Lebensmitteln und unter physiologischen Bedingungen". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-233695.
Texto completoAigster, Annelisse. "Physicochemical and Sensory Properties of Resistant Starch-Based Cereal Products and Effects on Glycemic and Oxidative Stress Responses in Hispanic Women". Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/28934.
Texto completoPh. D.
Vincens, Hélène. "Synthèse et utilisation de nouveaux groupements nucléofuges : application à l'alkylation énantiosélective". Rouen, 1987. http://www.theses.fr/1987ROUES010.
Texto completoDesmoulins, Lucie. "Détection hypothalamique du glucose chez le rat soumis à un régime gras enrichi en saccharose : rôle de la dynamique mitochondriale et des espèces actives de l'oxygène d'origine mitochondriale". Thesis, Dijon, 2016. http://www.theses.fr/2016DIJOS024/document.
Texto completoThe hypothalamus participates in the control of energy homeostasis by detecting circulating nutrients, such as glucose. The mediobasal hypothalamus (MBH), in particular, senses hyperglycemia and initiates physiological responses, e.g., insulin secretion via the autonomous (vagal) nervous system. We have recently demonstrated that glucose sensing requires mitochondrial reactive oxygen species (mROS) signaling heavily dependant on mitochondrial fusion and fission (dynamics). Recently, genetic models have associated some of these dynamics within the MBH to their obesogenic susceptibility. The aims of my thesis were first to establish a model that only presents a hypothalamic glucose sensing defect induced by a high fat high sucrose (HFHS) feeding in rats. After caracterizing this model, our objectives were to determine whether modulating the diet affects mitochondrial dynamics, and thus, mROS signaling, through the mitochondrial respiratory function in the hypothalamus. We finally reversed some dysregulated metabolic signalings potentially involved in mitochondrial dynamics in order to reverse the phenotype observed in HFHS fed rats. Our results demonstrate that after 3 weeks of HFHS feeding, rats had a normal body weight despite an increase in the fat mass compared to control rats. HFHS fed rats displayed also a glucose intolerance, increased fasting glycemia but no modification of fasting insulinemia. Hypothalamic glucose sensing induced insulin secretion, measured after an intra-carotid glucose injection towards the brain that only increases brain glycemia without alteration in peripheral glycemia, was drastically decreased. However, glucose stimulated insulin secretion in isolated islets was not different compared to controls. These defects correlate with a decrease of MBH ROS production in response to glucose, with no modification in the redox status. Efficiency of hypothalamic mitochondrial respiration was evaluated using oxygraphy, and results showed mitochondrial respiratory deficiencies in HFHS fed rats. The fission protein DRP1 exhibited decreased mitochondrial translocation in the MBH in response to glucose, suggesting decreased mitochondrial fission. The increase of AMPK activation in the hypothalamus was not responsible for the alteration of hypothalamic glucose sensing since its reversal with an intracerebroventricular (ICV) injection of compound C failed to restore brain hyperglycemia induced insulin secretion. Likewise, an ICV injection of leptin that induced STAT3 activation also failed to restore brain hyperglycemia induced insulin secretion. Finally, the decrease in AKT activation suggested a central insulin resistance. These results demonstrate for the first time that hypothalamic alteration of mitochondrial ROS signaling, fission and respiration were present in rats exposed to a 3 weeks HFHS diet. Such hypothalamic glucose sensing defects are early events preceding those in islets. These early but drastic hypothalamic modifications could participate in a primary nervous defect of the control of insulin secretion, and finally, the etablishment of a diabetic phenotype
Franconi, Jean-Michel. "Mise au point de sondes moleculaires pour l'etude par resonance magnetique nucleaire quantitative du fractionnement isotopique du deuterium accompagnant certaines reactions du metabolisme du glucose". Nantes, 1988. http://www.theses.fr/1988NANT2032.
Texto completoVieira, Thiago Antonio. "Síntese de C-glicosídeos e derivados a partir de fontes renováveis". Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/97/97136/tde-03122018-170834/.
Texto completoCarbohydrates are essential components of many natural products of great medicinal importance. The carbohydrate portions may increase the water solubility of drugs, decrease toxicity and/or contribute to the bioactivity of the natural products. The synthesis of Cglycosides, from D-glucose, is of great interest because they are useful as building blocks for the synthesis of various types of molecules with great potential as active principles for the treatment of cancer, diabetes, HIV, as antivirals, among others. C-glycosides are essentially inert to degradation because their natural anomeric center (an unstable O- or N-acetal) has been hydrolytically transformed into an ether linkage. Thus, significant attention has been devoted to the development of new synthetic routes. The Knoevenagel reaction, described over a century ago, consists of the condensation of aldehydes with molecules containing active methylene, such as malonic acid or its ester and diketones. Although it consists of a dehydration, surprisingly, the reaction is favored in aqueous medium in some cases. The condensation of unprotected carbohydrates with diketones has attracted increasing interest with the growing society\'s demand for cleaner (green) technologies. Based on the concept of Green Chemistry and its Twelve Principles, the aim was to reduce or substitute organic solventes for greener ones, adapt reaction systems to operate at milder temperatures and substitute raw materials for greener ones. The main goal was to prepare ketone-?-C-glucoside (CG) and its derivatives, from D-glucose, with potential application as drug intermediates. In this work, CG and D-glucose derivatives were prepared: peracetylated CG, peracetylated D-glucose, perbenzoylated CG, perbenzoylated D-glucose, chlorinated peracetylated CG, CGAr1 ((E)-4-(4- methoxyphenyl)-1-(3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yl)but-3-en-2- one), peracetylated CGAr1 and brominated peracetylated CGAr1. CG was prepared (35-80%) in water or EtOH-water (4:1), alkaline pH. Peracetylated CG (2,3,4,6-tetraacetyl-1-C-(?-Dglucopyranosyl) propan-2-one) and peracetylated D-glucose (1,2,3,4,6-pentacetyl-1-C-(?-Dglucopyranosyl)) were prepared (71 and 77,5%), using four methodologies: two using AcONa/ Ac2O at 50-90 °C, one with AcONa/py/DMAP at rt and one with I2/Ac2O at 28 °C. The perbenzoylated CG (2,3,4,6-tetrabenzoyl-1-C-(?-D-glucopyranosyl)propan-2-one) and perbenzoylated D-glucose (1,2,3,4,6-pentabenzoyl-1-C-(?-D-glucopyranosyl) were prepared (31 and 83%) using seven methodologies: two in NaOH aqueous solution, four with py and DCM and/or toluene as solvent at 65 °C. Chlorinated peracetylated CG (2-(acetoxymethyl)-6-(3- chloro-2-oxopropyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate) was prepared (19,6%) using NH4Cl/oxone in MeOH under reflux. CGAr1 was prepared from crude CG with p-anisaldehyde, L-proline and TEA in MeOH at rt (33,5%). The peracetylated CGAr1 ((E)-2-(acetoxymethyl)-6- (4-(4-methoxyphenyl)-2-oxobut-3-en-1-yl)-tetrahydro-2H-pyran-3,4,5-triyl triacetate) was prepared (54%) using three methodologies: Ac2O/AcONa at 50 °C, I2/Ac2O at 28 and at 50 °C. Brominated peracetylated CGAr1 was prepared (78%) using Br2/CCl4 at rt.
Carneiro, Lionel. "Détection hypothalamique de l'hyperglycémie : rôle de la dynamique mitochondriale dans la signalisation par les espèces actives de l'oxygène". Phd thesis, Université de Bourgogne, 2011. http://tel.archives-ouvertes.fr/tel-00689166.
Texto completoJunior, Fadi Antoine Taraboulsi. "Enzimas microbianas na conversão da sacarose em frutose e ácido glicônico usando reatores descontínuo-alimentado e contínuo com membrana". Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/9/9134/tde-28072010-113005/.
Texto completoSucrose is a commodity largely produced in Brazil and one of the most used and commercialized product in food industry. It can be converted through a multienzyme process in fructose and gluconic acid, which have commercial values higher than sucrose. Both products are imported by Brazil, being largely employed in the chemical, food and pharmaceutical industry. This work dealt with the hydrolysis of sucrose by invertase into fructose and glucose, and the oxidation of glucose to gluconic acid by glucose oxidase and catalase. Catalase was added in order to decompose the hydrogen peroxide an inhibitor of glucose oxidase formed as by-product of the oxidation. Two processes were employed. Fed-batch in which the hydrolysis and oxidation reactions were carried out separately by adding invertase followed by glucose oxidase and catalase was conducted by adding the solution of substrate according to a constant, increasing linear, decreasing linear, increasing exponential or decreasing exponential mode. The best fed-batch performance was attained through the decreasing linear addition of sucrose (64g/L) and glucose (32g/L). Setting this kind of addition and using all enzymes simultaneously, the direct conversion of sucrose to fructose and gluconic acid occurred at a yield of 72%. The continuous process was carried out in a cell-type membrane reactor (membrane cut off = 100 kDa), in which the sucrose conversion was made by using all enzymes simultaneously, leading to a final yield of about 76%
Benhaddou, Rachida. "Arylation de doubles liaisons catalyses par le palladium : influence de differents facteurs sur la cinetique de la reaction, etude de nouvelles syntheses d'aryl-c-glycosides". Paris 6, 1988. http://www.theses.fr/1988PA066065.
Texto completoValle, Maíra Mello Rezende. "Alterações na homeostase redox das células beta pancreáticas em resposta à glicose". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-19022015-163014/.
Texto completoROS production in pancreatic beta cells has been associated with the insulin secretion process but the mechanism by which glucose affects the redox state in these cells remains unknown. In order to address this issue, we evaluated the effect of 1 or 48 hours incubation of pancreatic beta cells with various glucose concentrations (2.8, 5.6, 8.3, 11.1, 16.7 and 20 mM). Glucose loading induced superoxide production by mitochondria and NADPH oxidase complex, and enhanced the antioxidant capacity by increasing GSH content and modulate expression of antioxidant enzymes. Glucose also promoted Rac1/Sod1 interaction that maintains NADPH oxidase activated. These cells however did not present redox endosomes, the redoxosomes, in response to glucose loading. These effects might be associated with the process of insulin secretion and pancreatic beta cell death.
Lebeau, Thierry. "Fermentation alcoolique de mélanges glucose-xylose par les levures Candida shehatae et Saccharomyces cerevisiae co-immobilisées dans un nouveau type de bioréacteur à membrane". Rouen, 1997. http://www.theses.fr/1997ROUES014.
Texto completoMarklund, Niklas. "The role of reactive oxygen species in traumatic brain injury : Experimental studies in the rat". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5053-9/.
Texto completoWu, Liya [Verfasser] y Klaus [Akademischer Betreuer] Parhofer. "The effect of walnut consumption on lipid and glucose metabolism, adipokines, C-reactive protein, endothelial function, body weight and blood pressure in healthy men and healthy postmenopausal women / Liya Wu. Betreuer: Klaus Parhofer". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1111505276/34.
Texto completoMenéndez, Aguirre Orquídea de María Pastora. "Stability of microbial transglutaminase and its reactions with individual caseins under atmospheric and high pressure". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2006. http://nbn-resolving.de/urn:nbn:de:swb:14-1161695264565-75969.
Texto completoLefrançois, Pauline. "Développement d’un microréacteur biomimétique pour l'analyse in situ d'activités enzymatiques par couplage de l’électrochimie et de la microscopie de fluorescence". Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0759/document.
Texto completoEnzymatic reactions are involved in many physiological phenomena in living organisms. These reactions are based on protons and electrons transfers and can lead to the production of by-products. Among them, reactive oxygen and nitrogen species (ROS and RNS) are of great interest as they play a double role: on the one hand by allowing the organism to react to a stress by the activation of signaling redox pathways, and on the other hand, ROS and RNS can cause oxidative damages to tissues ensuing dysfunctions in the organism. The high reactivity of such species induce their short lifetimes (ns-min) and leads to uncertainties when it comes to the study of some enzymatic reactions in bulk. This PhD project aims to develop a biomimetic microreactor for the study of enzymatic ac-tivities producing ROS/RNS. Indeed, by confining a reaction within a cell-sized compartment (20-100 μm diameter), the generated species (H2O2, NO•, NO2-) could be analyzed in situ with a quantita-tive and kinetic resolution. Giant unilamellar vesicles are formed in physiological conditions and are used as microreactors for the monitoring of enzymatic activities of glucose oxidase and NO-synthases. Fluorescence microscopy allows individual vesicle observation and the monitoring of reactions trig-gered by microinjection. Then, released species are detected in real-time by electrochemistry in order to decipher the diverse enzymatic pathways of NO-Synthases
Tolliver, Benjamin M., Devaiah P. Shivakumar y Cecelia A. McIntosh. "Effects of Amino Acid Insertion on the Substrate and Regiospecificity of a Citrus paradisi Glucosyltransferase". Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/345.
Texto completoTolliver, Benjamin M., Devaiah P. Shivakumar y Cecelia A. McIntosh. "Effects of Amino Acid Sequence Insertion on the Substrate Preference of a Citrus Paradisi Glucosyltransferase". Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/347.
Texto completoPenn-Marshall, Michelle. "The Effects of Resistant Starch Intake in African-American Americans at Increased Risk for Type 2 Diabetes". Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/28104.
Texto completoPh. D.
Miqueleto, Ana Paula. "Comportamento de reator anaeróbio operado em batelada seqüencial, contendo biomassa imobilizada e submetido a aumento progressivo da concentração de substrato de fácil degradação". Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-02072009-085827/.
Texto completoThe main objectives of this study were to evaluate the performance of the anaerobic sequencing batch reactor when subjected to a progressive increasing of the influent glucose concentration and estimate the kinetic parameters of glucoses degradation. Initially the reactor was operated with 8-hour cycles, treating glucose at concentrations of 500, 1000 and 2000 mg/L. Glucose was not detected in the effluent in all these three conditions. The reactor showed operating stability treating glucose concentration of approximately 500mg/L, with efficiencies between 93% to 97% in the filtrated COD removal. In the operation with glucose concentrations of 1000 mg/L and 2000 mg/L, approximately, it could be noticed an operational instability, caused mainly by a production of extracellular polymers (EPS) leading to hydrodynamic and mass transfer problems in the reactor. The mean values of volatile acids concentration in the effluent were about 159 ± 72mg/L and 374 ± 92mg/L, respectively. A first order model was adjusted to glucose concentration profiles, and a modified model, including a residual concentration of substrate, was adjusted to COD temporal profiles. To verify the EPS formation, the reactor was operated with 3-hour cycle in the concentrations of 500 and 1000 mg/L This stage had the objective of verifying if the EPS production would result from the exposure of the biomass to low concentration of substrate for a long period of time. Thus, reducing the time cycle, the exposure to low concentrations would also be reduced. Nevertheless, even with the reactor operating with relative stability, the hypotheses could not be verified due the formation of a large amounts of EPS right in the first operational condition with approximately to 500 mg/L of glucose in the influent, showing that the hypothesis was not right.
Neves, Luiz Carlos Martins das. "Emprego de reator com membrana na obtenção de frutose e ácido glicônico a partir da sacarose". Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/9/9134/tde-11082017-170439/.
Texto completoThe fructose and gluconic acid are products of great application in chemical, pharmaceutical and food industry. The actual Brazilian market for these compounds is about US$ 2 millions, here as the sucrose, the raw-material used for their production, represents about 2.4% of the Brazil\'s GNP. This conversion increases the value added to the sugarcane, usually marketed as a commodity, because the fructose and gluconic acid are more valuable products than sucrose. The use of membrane bioreactor (MBR), which operates under mild conditions regarding internal pressure, temperature and pH, has been growing along the years for enzyme catalyzed processes. Moreover, in the MBR the reaction and separation of the products occur simultaneously, avoiding the formation of by-products and the eventual inhibition of the enzyme caused by excess of substrate or products. The sucrose is converted to the inverted syrup (an equimolar solution of fructose and glucose) by invertase (in this work was employed Bioinvert®, a commercial invertase) followed by the oxidation of glucose in gluconic acid by the glucose oxidase (GO). The multi-enzymatic conversion of sucrose was attained when carried out under initial substrate of 50mM and invertase, glucose oxidase and catalase concentrations, respectively, of 24.0 U/mL, 0.5 U/mL and 470 U/mL in a membrane reactor utilizing a dilution rate of 6.0 h-1, 35ºC and pH 5.5. The optimized operational conditions led to a conversion yield of 100% for sucrose hydrolysis and glucose oxidation steps resulting in enzyme productivity of 4.2 mmol/U.h, 0.60 mmol/U.h and 0.00062 mmol/U.h, respectively, to invertase, glucose oxidase and catalase. In regard to the glucose oxidation, the addition of catalase in the reaction medium was necessary, in order to minimize the inhibition of the GO by the hydrogen peroxide formed.