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Tesis sobre el tema "Genomic trait"

Autor: Grafiati
Publicado: 25 de mayo de 2024
Última modificación: 31 de julio de 2025

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1

Kindt, Alida Sophie Dorothea. "Genomic signature of trait-associated variants." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9620.

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Genome-wide association studies have been used extensively to study hundreds of phenotypes and have determined thousands of associated SNPs whose underlying biology and causation is as yet largely unknown. Many previous studies attempted to clarify the causal biology by investigating overlaps of trait-associated variants with functional annotations, but lacked statistical rigor and examined incomplete subsets of available functional annotations. Additionally, it has been difficult to disentangle the relative contributions of different annotations that may show strong correlations with one anot
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2

Hu, Wei. "Genomic determinants of alcohol effects /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008. http://proquest.umi.com/pqdweb?did=1545571871&sid=1&Fmt=6&clientId=18952&RQT=309&VName=PQD.

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Thesis (Ph.D. in Pharmacology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 121-149). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;
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3

Huang, Mao. "Accuracy of genomic selection in a soft winter wheat (Triticum aestivum L.) breeding program." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1468841458.

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4

Ward, Brian Phillip. "Genomic Prediction and Genetic Dissection of Yield-Related Traits in Soft Red Winter Wheat." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/85503.

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In multiple species, genome-wide association (GWA) studies have become an increasingly prevalent method of identifying the quantitative trait loci (QTLs) that underlie complex traits. Despite this, relatively few GWA analyses using high-density genomic markers have been carried out on highly quantitative traits in wheat. We utilized single-nucleotide polymorphism (SNP) data generated via a genotyping-by-sequencing (GBS) protocol to perform GWA on multiple yield-related traits using a panel of 329 soft red winter wheat genotypes grown in four environments. In addition, the SNP data was used to
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5

Lin, Meng. "Genetic and genomic studies on wheat pre-harvest sprouting resistance." Diss., Kansas State University, 2016. http://hdl.handle.net/2097/34597.

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Doctor of Philosophy<br>Department of Agronomy<br>Guihua Bai<br>Allan K. Fritz<br>Wheat pre-harvest sprouting (PHS), germination of physiologically matured grains in a wheat spike before harvesting, can cause significant reduction in grain yield and end-use quality. Many quantitative trait loci (QTL) for PHS resistance have been reported in different sources. To determine the genetic architecture of PHS resistance and its relationship with grain color (GC) in US hard winter wheat, a genome-wide association study (GWAS) on both PHS resistance and GC was conducted using in a panel of 185 U.S. el
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6

Masekoameng, Tshepiso. "Sickle cell trait and targeted genomic variants in chronic kidney disease an African cohort." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31357.

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Background Chronic Kidney Disease (CKD), has a high and increasing burden in sub-Saharan Africa. Environmental factors that have been associated to CKD are associated with multiple co-morbidities such as hypertension, diabetes, and HIV. Some genetics factors such APOL1 have been associated with the highest burden of CKD among population of African ancestries. Other emerging genetic factors such as Sickle Cell trait (SCT) have been investigated mostly among African Americans. Sickle Cell trait (SCT) has the highest burden in sub-Saharan Africans, because of a natural selection, attributed to it
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7

Pecoraro, Carlo <1986&gt. "Global Population Genomic Structure and Life History Trait Analysis of Yellowfin Tuna (Thunnus Albacares)." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7537/1/Pecoraro_Carlo_tesi.pdf.

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Yellowfin tuna (Thunnus albacares; YFT) represents one of the most important seafood commodities in the world. The rationale of this Ph.D. project was identified by prioritizing key issues as objectives for contributing to the conservation of YFT and helping to develop a more realistic stock assessment and sustainable management of this species. Specifically, in this work the current mismatch between the biology and/or ecology and the realized management strategies was highlighted, putting particular emphasis on YFT population structure, which is currently characterized by a high degree of unc
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8

Pecoraro, Carlo <1986&gt. "Global Population Genomic Structure and Life History Trait Analysis of Yellowfin Tuna (Thunnus Albacares)." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7537/.

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Yellowfin tuna (Thunnus albacares; YFT) represents one of the most important seafood commodities in the world. The rationale of this Ph.D. project was identified by prioritizing key issues as objectives for contributing to the conservation of YFT and helping to develop a more realistic stock assessment and sustainable management of this species. Specifically, in this work the current mismatch between the biology and/or ecology and the realized management strategies was highlighted, putting particular emphasis on YFT population structure, which is currently characterized by a high degree of unc
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9

He, Feng, and 贺峰. "Detection of parent-of-origin effects and association in relation to aquantitative trait." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44921408.

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10

Toubiana, William. "Towards an adaptive and genomic understanding of an exaggerated secondary sexual trait in water striders." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSEN058/document.

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Les nombreuses différences qui existent entre les organismes illustrent que le processus de variation est un phénomène universel en biologie. Ces variations sont particulièrement observables chez les espèces sexuées, entre mâles et femelles. Comprendre les différents facteurs biologiques, environnementaux et génétiques, à l'origine de ce dimorphisme sexuel est le cœur de mon sujet de thèse. Pour cela, j’ai établi un nouveau modèle d'étude, l’insecte semi-aquatique Microvelia longipes. Ces insectes ont évolué un dimorphisme sexuel spectaculaire où les mâles présentent une croissance extrême et
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11

Das, Samarendra. "Statistical Approaches of Gene Set Analysis with Quantitative Trait Loci for High-throughput Genomic Studies." Dissertation/Thesis, University of Louisville, 2020. http://krishi.icar.gov.in/jspui/handle/123456789/74070.

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Ph.D. Dissertation Thesis<br>Recently, gene set analysis has become the first choice for gaining insights into the underlying complex biology of diseases through high-throughput genomic studies, such as Microarrays, bulk RNA-Sequencing, single cell RNA-Sequencing, etc. It also reduces the complexity of statistical analysis and enhances the explanatory power of the obtained results. Further, the statistical structure and steps common to these approaches have not yet been comprehensively discussed, which limits their utility. Hence, a comprehensive overview of the available gene set analysis app
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12

Shen, Xia. "Novel Statistical Methods in Quantitative Genetics : Modeling Genetic Variance for Quantitative Trait Loci Mapping and Genomic Evaluation." Doctoral thesis, Uppsala universitet, Beräknings- och systembiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-170091.

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This thesis develops and evaluates statistical methods for different types of genetic analyses, including quantitative trait loci (QTL) analysis, genome-wide association study (GWAS), and genomic evaluation. The main contribution of the thesis is to provide novel insights in modeling genetic variance, especially via random effects models. In variance component QTL analysis, a full likelihood model accounting for uncertainty in the identity-by-descent (IBD) matrix was developed. It was found to be able to correctly adjust the bias in genetic variance component estimation and gain power in QTL m
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13

Kitami, Toshimori. "GENETIC, EVOLUTIONARY, AND GENOMIC ANALYSIS OF HOMOCYSTEINE AND FOLATE PATHWAY REGULATION." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1127865525.

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14

Ladejobi, Olufunmilayo Olubukola. "Testing new genetic and genomic approaches for trait mapping and prediction in wheat (Triticum aestivum) and rice (Oryza spp)." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277449.

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Advances in molecular marker technologies have led to the development of high throughput genotyping techniques such as Genotyping by Sequencing (GBS), driving the application of genomics in crop research and breeding. They have also supported the use of novel mapping approaches, including Multi-parent Advanced Generation Inter-Cross (MAGIC) populations which have increased precision in identifying markers to inform plant breeding practices. In the first part of this thesis, a high density physical map derived from GBS was used to identify QTLs controlling key agronomic traits of wheat in a gen
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15

Adhikari, Bishwo. "Genomic Analysis of Nematode-Environment Interaction." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2578.

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The natural environments of organisms present a multitude of biotic and abiotic challenges that require both short-term ecological and long-term evolutionary responses. Though most environmental response studies have focused on effects at the ecosystem, community and organismal levels, the ultimate controls of these responses are located in the genome of the organism. Soil nematodes are highly responsive to, and display a wide variety of responses to changing environmental conditions, making them ideal models for the study of organismal interactions with their environment. In an attempt to exa
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16

Tsai, Hsin Yuan. "Genomic basis of growth traits and host resistance against sea lice (L. Salmonis) in Atlantic salmon (S. Salar)." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28918.

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Background Atlantic salmon (Salmo Salar) is a key aquaculture species in several countries. Since its critical role in economic sector and scientific research, this species has been relatively extensively investigated, in comparison with other farmed and wild aquatic species. However, the genetic components associated with growth and fillet-related traits are lack consistency, and the issue of sea louse disease in both wild and famed salmon is still unsolved. Objectives Overall aim of this project was to understand the genetic basis of growth-related traits and host resistance to sea lice usin
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17

Marondedze, Claudius. "Functional genomic characterization of fruit quality traits in apple (Malus x domestica Borkh)." Thesis, University of the Western Cape, 2009. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_7794_1286309138.

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<p>&nbsp<br></p> <p align="left">The domesticated apple (<i><font face="TimesNewRomanPS-ItalicMT">Malus </font><font face="TimesNewRomanPSMT">x </font><i><font face="TimesNewRomanPS-ItalicMT">domestica </font><font face="TimesNewRomanPSMT">Borkh.), belonging to the </font><i><font face="TimesNewRomanPS-ItalicMT">Malus </font><font face="TimesNewRomanPSMT">genus of the Rosaceae family, is one of the edible pomaceous fruits. Since it is one of the important commercial fruit crops worldwide, the quality of the fruit is crucial to breeders and farmers as it ultimately determines acceptance of a cu
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18

Waghulde, Harshal B. "Mapping and CRISPR/Cas9 Gene Editing for Identifying Novel Genomic Factors Influencing Blood Pressure." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1470402637.

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19

Savoia, Simone. "Innovative tools for phenotypic characterization and genetic improvement of meat quality in piemontese breed." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425884.

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The main objective of this thesis was to perform a comprehensive investigation of the possibilities for the improvement of meat quality traits focusing on the development of innovative tools. The study was carried out sampling 1,327 Piemontese young bulls. Animals were fattened in 115 farms and slaughtered at the same commercial abattoir. Information about farms fattening system was collected through on field surveys. After slaughter, the following carcass traits were recorded: carcass weight, carcass conformation, age at slaughter and carcass daily gain. Individual samples of the Longissim
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20

Liabeuf, Debora. "Development of Processing Tomato Lines Resistant to Xanthomonas gardneri: from Screening to Breeding." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1480522067298667.

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21

Rain, Franco Angel. "Consequences of environmental disturbances on community structure and functioning of aquatic prokaryotes." Electronic Thesis or Diss., Sorbonne université, 2021. https://theses.hal.science/tel-03730170.

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Les microbes sont affectés par les perturbations environnementales qui affectent la stabilité fonctionnelle des communautés microbiennes. Cependant, leurs réponses sont complexes, difficiles à élucider et les mécanismes de la stabilité fonctionnelle sont encore mal compris. Dans cette thèse, j'ai étudié les réponses microbiennes aux perturbations environnementales, des populations uniques aux communautés complexes. Dans le cas d'une population unique, nous avons étudié la réponse transcriptionnelle de populations bactériennes uniques dont la niche varie le long d'un gradient environnemental. P
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22

Schneider, Rhiannon N. "Genome-Wide Analyses for Partial Resistance to Phytophthora sojae Kaufmann and Gerdemann in Soybean (Glycine max L. Merr.) Populations from North America and the Republic of Korea." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429741967.

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23

Schiavo, Giuseppina <1986&gt. "Analysis of the pig genome for the identification of genomic regions affecting production traits." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6919/1/Schiavo_Giuseppina_Tesi_Dottorato_XVII_ciclo.pdf.

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The aim of this work was to identify markers associated with production traits in the pig genome using different approaches. We focused the attention on Italian Large White pig breed using Genome Wide Association Studies (GWAS) and applying a selective genotyping approach to increase the power of the analyses. Furthermore, we searched the pig genome using Next Generation Sequencing (NSG) Ion Torrent Technology to combine selective genotyping approach and deep sequencing for SNP discovery. Other two studies were carried on with a different approach. Allele frequency changes for SNPs affecting
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24

Schiavo, Giuseppina <1986&gt. "Analysis of the pig genome for the identification of genomic regions affecting production traits." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6919/.

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The aim of this work was to identify markers associated with production traits in the pig genome using different approaches. We focused the attention on Italian Large White pig breed using Genome Wide Association Studies (GWAS) and applying a selective genotyping approach to increase the power of the analyses. Furthermore, we searched the pig genome using Next Generation Sequencing (NSG) Ion Torrent Technology to combine selective genotyping approach and deep sequencing for SNP discovery. Other two studies were carried on with a different approach. Allele frequency changes for SNPs affecting
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25

Nsibi, Mariem. "Contribution des stratégies de sélection génomique et phénomique aux programmes d'amélioration génétique de l'abricotier (Prunus armeniaca L.) pour quelques traits d'intérêt." Electronic Thesis or Diss., Montpellier, SupAgro, 2021. http://www.theses.fr/2021NSAM0021.

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L'adossement de l'amélioration génétique des espèces animales et végétales aux progrès technologiques a permis l'avènement de stratégies récentes de sélection s'appuyant sur des données à haut-débit. Le progrès génétique résultant, sous-tendu par l'étude de l'architecture génétique des caractères d'intérêt agronomique, permet désormais un changement de paradigme pour substituer à une démarche de caractérisation des candidats à la sélection une démarche de prédiction de leur réponse à la variation environnementale.Ainsi, la sélection génomique (SG) fondée sur la contribution de plusieurs dizain
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26

Voutsina, Nikol. "Elucidating the genomics of nutritional and morphological traits in watercress (Nasturtium officinale R. Br.) : the first genomic resources." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/425884/.

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Watercress (<i>Nasturtium officinale</i> R. Br.; Brassicaceae) has a long history of human use for medicine and consumption. In recent years, it has received a large deal of attention as one of the most nutrient-dense foods. Despite this, watercress remains largely underdeveloped with limited breeding resources through which to meet current and future intensifying market demands, such as for a more compact morphology, enhanced nutritional benefits and resource-use efficiency. The aim of this PhD has been to characterize the genetic structure of nutritional and morphological traits in watercres
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27

Tamarit, Daniel. "Evolution of symbiotic lineages and the origin of new traits." Doctoral thesis, Uppsala universitet, Molekylär evolution, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-301939.

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This thesis focuses on the genomic study of symbionts of two different groups of hymenopterans: bees and ants. Both groups of insects have major ecological impact, and investigating their microbiomes increases our understanding of their health, diversity and evolution. The study of the bee gut microbiome, including members of Lactobacillus and Bifidobacterium, revealed genomic processes related to the adaptation to the gut environment, such as the expansion of genes for carbohydrate metabolism and the acquisition of genes for interaction with the host. A broader genomic study of these genera d
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28

Ben, Sadoun Sarah. "Optimisation du schéma de sélection chez le blé tendre : apport des prédictions génomiques et des caractères corrélés." Thesis, Université Clermont Auvergne‎ (2017-2020), 2020. http://www.theses.fr/2020CLFAC014.

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La sélection variétale consiste à créer de nouvelles variétés répondant aux exigences du marché pour plusieurs caractères d’intérêt agronomique. L’objectif de la thèse était d’étudier l’apport des prédictions génomiques pour optimiser les programmes de sélection chez le blé tendre. Dans un premier chapitre, nous avons testé des méthodes visant à améliorer la précision les prédictions génomiques d’un caractère cher à mesurer en utilisant un caractère corrélé moins cher à mesurer, sans augmenter le budget alloué au phénotypage. Nous avons utilisé un modèle de prédiction génomique multi-caractère
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29

McClure, Matthew Charles Taylor J. "Genome scan in commercial angus cattle for quantitative trait loci influencing growth, carcass, and reproductive traits." Diss., Columbia, Mo. : University of Missouri-Columbia, 2009. http://hdl.handle.net/10355/7006.

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The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on January 6, 2010). Vita. Thesis advisor: Jeremy Taylor. "July 2009" Includes bibliographical references.
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30

Sampson, Joshua Neil. "Clustering genes in genetical genomics /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/9549.

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31

Passador-Gurgel, Gisele Candia. "Quantitative Trait Transcript Mapping for Drug Response in Drosophila melanogaster." NCSU, 2005. http://www.lib.ncsu.edu/theses/available/etd-11132005-160424/.

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Here I used microarrays to identify genes that are activated or repressed by nicotine and caffeine in Drosophila melanogaster. I compared genotypes with differential resistance to each drug in order to select genes that may be involved in resistance to the drugs. Comparison of the genes differentially expressed by both drugs leads me to propose that there are common mechanisms of metabolic resistance to caffeine and nicotine, in particular cytochrome P-450-mediated mechanisms. Caffeine seems to have a more dramatic influence on gene expression than nicotine, in particular on expression of gene
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32

Olatoye, Olalere Marcus. "Quantitative genomic analysis of agroclimatic traits in sorghum." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/38251.

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Doctor of Philosophy<br>Department of Agronomy<br>Geoffrey Morris<br>Climate change has been anticipated to affect agriculture, with most the profound effect in regions where low input agriculture is being practiced. Understanding of how plants evolved in adaptation to diverse climatic conditions in the presence of local stressors (biotic and abiotic) can be beneficial for improved crop adaptation and yield to ensure food security. Great genetic diversity exists for agroclimatic adaptation in sorghum (Sorghum bicolor L. Moench) but much of it has not been characterized. Thus, limiting its util
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33

Moscatelli, Giulia <1992&gt. "Genomic characterisation of pigmentation related traits in livestock." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/9995/3/moscatelli_giulia_tesi_Finale.pdf.

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With the intense use of high throughput genomic technologies, our knowledge about the cattle and pig genomes has rapidly evolved. Over the last years, many investigations have been already carried out to identify major genes and mutations underlying different morphological, productive, and reproductive traits in cattle and pigs. This thesis is the result of research activities focused on the investigation of genomic features to find novel candidate gene markers associated with pigmentation in two Italian local cattle breeds (Reggiana and Modenese) and in an Italian heavy pig breed, the Italia
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34

Macdonald, Stuart J. "Evolutionary and genomic analyses of complex traits in Drosophila." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365832.

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35

Benazir, Katarina Marquez. "Molecular Marker Applications in Oat (Avena Sativa L.) Breeding and Germplasm Diagnostics." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31148.

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The ability to identify germplasm and select traits accurately is fundamental to successful plant breeding. Pedigrees and molecular markers facilitate these processes; however misleading experimental results can occur when incorrect relationships and/or cultivar names are recorded. Molecular markers can identify these inconsistencies, and with advances in genotyping technology these diagnostics can be done faster and more objectively. This study aimed to develop molecular marker assays and graphical genotyping methodologies for cultivar identification, seed purity assessment and trait selectio
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36

Lynch, Michael David. "Genomics tools for elucidating the function of trait conferring genes." Diss., Connect to online resource, 2005. http://wwwlib.umi.com/cr/colorado/fullcit?p3190382.

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37

O'Brien, Mitchell John. "Genetics and genomics of myxomatous mitral valve disease in dogs." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27483.

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As a result of its unique evolutionary history, the modern dog (Canis lupus familiaris) has a simplified genetic landscape that makes it a strong model for investigating the genetic basis of breed specific traits and diseases. This thesis applies genomic methodologies to a complex disease, myxomatous mitral valve disease (MMVD), with the primary aim of improving our understanding of its genetic basis. MMVD is an acquired disease of the dog that causes valvular dysfunction and may result in the development of congestive heart failure (CHF). In dogs, MMVD is the most frequent cause of cardiovasc
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38

Wragg, David. "Genomic control of Mendelian traits in fancy and village chicken." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665482.

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Traditional chicken breeds exhibit a range of phenotypic diversity, which in some cases is far removed from that of their jungle fowl ancestors. This diversity includes plumage pattern and colouration, feather stlUcture, comb morphology, egg colour, and numerous other behavioural and morphological characteristics. Extensive research over the last century has identified that a number of these phenotypic traits are inherited in a Mendelian fashion, enabling them to be studied at the genetic level with relative ease. Typically, the genetic mapping of these traits has required establishing resourc
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39

Alvarenga, Amanda Botelho. "Feed efficiency traits in Santa Inês sheep under genomic approaches." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-20032018-160145/.

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The selection on genetic values predicted from markers could substantially increase the rate of genetic gain in animals by increasing accuracy of prediction and reducing generation interval, especially for difficult to measure traits, such as feed efficiency. Feed efficiency is the most important trait in animal production due to its impacts on cost of production and environmental factors. Many metrics measure the feed efficiency, such as ratio of gain to feed (FER), the ratio of feed to gain (FCR) and residual feed intake (RFI). Nevertheless, in ovine, no study with the aim of understand the
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40

Pilling, Luke C. "Human population studies of transcriptome-wide expression in age-related traits." Thesis, University of Exeter, 2015. http://hdl.handle.net/10871/17471.

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This thesis presents novel investigations of three common ageing phenotypes in human population studies, using microarray technology to assess ‘transcriptome-wide’ expression in whole blood to identify mechanisms and biomarkers. Muscle strength is related to frailty and is predictive of disability in older persons. I assessed the association between transcript abundance in the InCHIANTI peripheral blood samples (N=695) and muscle strength. One gene (CEBPB) passed the multiple testing criteria, and is involved in macrophage-mediated repair of damaged muscle. I extended this work with a meta-ana
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41

Lam, Alex C. "Design and analysis of genetical genomics studies and their potential applications in livestock research." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3950.

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Quantitative Trait Loci (QTL) mapping has been widely used to identify genetic loci attributable to the variation observed in complex traits. In recent years, gene expression phenotypes have emerged as a new type of quantitative trait for which QTL can be mapped. Locating sequence variation that has an effect on gene expression (eQTL) is thought to be a promising way to elucidate the genetic architecture of quantitative traits. This thesis explores a number of methodological aspects of eQTL mapping (also known as “genetical genomics”) and considers some practical strategies for applying this a
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42

Guan, Dailu. "Genomic analysis of dairy and pigmentation traits in Murciano-Granadina goats." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671155.

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Amb l'objectiu d'obtenir nous coneixements sobre la base molecular de la lactació en cabres de la raça Murciano-Granadina (MUG), hem dut a terme una anàlisi RNA-Seq de mostres de la glàndula mamària (N=7) obtingudes en tres punts temporals diferents: 78 dies (T1, lactació primerenca), 216 dies (T2, lactació tardana) i 285 dies (T3, període sec) després del part. Aquest experiment ens va permetre identificar 1654 gens expressats diferencialment (DE), les funcions dels quals estaven relacionades principalment amb el metabolisme de les proteïnes, lípids i carbohidrats, homeòstasi del calci, mort
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43

Muñoz, Andirkó Alejandro Gregorio. "Modern brains and bones: genomic analysis of derived Homo sapiens traits." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672530.

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Over the last years we have come to realize that the history of our species is not as simple as we once thought. We are now faced with complex demographic scenarios, events of admixture with human species and the realization that our differences with Neanderthals might be of gradient, not quality. Knowing all of this, we have to face the question of what did in fact change since the emergence of our species, to what extent, when did it happened in our evolution, and what consequences those changes bring for complex traits. This thesis tries to contribute answers to these questions, either thro
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44

Langley, Sarah Raye. "Modelling genetic and genomic interactions underlying gene expression and complex traits." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/10925.

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This study focuses on integrating and applying computational techniques for modelling quantitative traits and complex diseases, such as hypertension and diabetes, using the rat model system and translating the findings to humans. Complex disease traits are heritable, highly polygenic, and influenced by environmental factors. Human studies, like Genome Wide Association Studies (GWAS), have identified many genetic determinants underlying these traits but have provided little information about the functional effects of these variants and mechanisms regulating the disease. This study takes a syste
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45

Ogawa, Shinichiro. "Studies on genomic prediction for carcass traits in Japanese Black cattle." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225652.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第20427号<br>農博第2212号<br>新制||農||1048(附属図書館)<br>学位論文||H29||N5048(農学部図書室)<br>京都大学大学院農学研究科応用生物科学専攻<br>(主査)准教授 谷口 幸雄, 教授 今井 裕, 教授 廣岡 博之<br>学位規則第4条第1項該当
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46

Marklund, Lena. "Genome analysis of quantitative trait loci in the pig /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1997. http://epsilon.slu.se/avh/1997/91-576-5416-6.gif.

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47

Hulur, Imge, Eric R. Gamazon, Andrew D. Skol, et al. "Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci." BioMed Central Ltd, 2015. http://hdl.handle.net/10150/610285.

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BACKGROUND: Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with diseases of the colon including inflammatory bowel diseases (IBD) and colorectal cancer (CRC). However, the functional role of many of these SNPs is largely unknown and tissue-specific resources are lacking. Expression quantitative trait loci (eQTL) mapping identifies target genes of disease-associated SNPs. This study provides a comprehensive eQTL map of distal colonic samples obtained from 40 healthy African Americans and demonstrates their relevance for GWAS of colonic d
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Cheng, Jie [Verfasser]. "Genomic Mapping of Speciation-Related Traits in Hybridizing Sculpins (Cottus) / Jie Cheng." Kiel : Universitätsbibliothek Kiel, 2013. http://d-nb.info/1037109406/34.

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Ober, Ulrike Verfasser], Martin [Akademischer Betreuer] Schlather, and Henner [Akademischer Betreuer] [Simianer. "Genomic Prediction for Quantitative Traits: Using Kernel Methods and Whole Genome Sequence Based Approaches / Ulrike Ober. Gutachter: Martin Schlather ; Henner Simianer. Betreuer: Martin Schlather." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1044248440/34.

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Zhou, Hua, Jin Zhou, Eric Sobel, and Kenneth Lange. "Fast genome-wide pedigree quantitative trait loci analysis using MENDEL." BioMed Central, 2014. http://hdl.handle.net/10150/610091.

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The linkage era left a rich legacy of pedigree samples that can be used for modern genome-wide association sequencing (GWAS) or next-generation sequencing (NGS) studies. Family designs are naturally equipped to detect rare variants, control for population stratification, and facilitate the study of parent-of-origin effects. Unfortunately, pedigree likelihoods are notoriously hard to compute, and current software for association mapping in pedigrees is prohibitively slow in processing dense marker maps. In a recent release of the comprehensive genetic analysis software MENDEL, we implemented an
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