Tesis sobre el tema "Genetic loci"
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Chilakamarri, Sunita R. "Genetic differentiation in Alewife populations using microsatellite loci". Link to electronic thesis, 2005. http://www.wpi.edu/Pubs/ETD/Available/etd-053105-164623/.
Texto completoNicholls, Felicity K. M. "Genetic analysis of the gene Additional sex combs and interacting loci". Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29644.
Texto completoScience, Faculty of
Zoology, Department of
Graduate
Good, David Andrew y n/a. "Genetic Loci for Paget's Disease of Bone". Griffith University. School of Biomolecular and Biomedical Science, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040319.125358.
Texto completoGood, David Andrew. "Genetic Loci for Paget's Disease of Bone". Thesis, Griffith University, 2003. http://hdl.handle.net/10072/365759.
Texto completoThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
Full Text
Roberts, Simon Benedict. "Investigating new genetic susceptibility loci in osteoarthritis". Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/28982.
Texto completoAhmed, Helal Uddin. "Mapping stress tolerance genetic loci in Arabidopsis thaliana". Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246628.
Texto completoOakenfull, Elizabeth Ann. "A molecular genetic study of equid #alpha#-globin loci". Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317915.
Texto completoMavridou, Annoula. "Genetic loci of Rhizobium leguminosarum affecting nod gene expression". Thesis, University of East Anglia, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316102.
Texto completoKing, Alistair Lawrence. "Studies to identify genetic susceptibility loci in coeliac disease". Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406682.
Texto completoRask-Andersen, Mathias. "Obesity Genetics : Functional Aspects of Four Genetic Loci Associated with Obesity and Body Mass". Doctoral thesis, Uppsala universitet, Funktionell farmakologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-204449.
Texto completoCampino, Susana. "Genetic analysis of murine malaria". Doctoral thesis, Umeå universitet, Medicinsk biovetenskap, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-124.
Texto completoGoode, Ellen Lee. "Epidemiology of hereditary prostate cancer : genetic analysis of susceptibility loci incorporating clinical characteristics /". Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/10856.
Texto completoMaller, Julian Benjamin. "Fine scale mapping of genetic loci associated with human disease". Thesis, University of Oxford, 2013. https://ora.ox.ac.uk/objects/uuid:2e1dcc74-cccb-4253-961c-431e965bf204.
Texto completoBett, Kirstin E. "Genome analysis and genetic mapping of restorer loci in Raphanus". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63844.pdf.
Texto completoWilhelm, Edward. "Genetic analysis of the Group IV Rht LOCI in wheat". Thesis, University of East Anglia, 2011. https://ueaeprints.uea.ac.uk/49761/.
Texto completoHarenza, Jo Lynne. "Genetic Dissection of Quantitative Trait Loci for Substances of Abuse". VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3190.
Texto completoQianren, Jin. "Search for susceptibility loci and candidate genes for breast cancer /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-030-3/.
Texto completoNagy, Réka. "Genetic analysis using family-based populations". Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/28978.
Texto completoMcEwen, Kirsten Rose. "Epigenetic regulation of imprinted loci in the mouse". Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609297.
Texto completoNyström, Per-Erik. "Quantitative trait loci in pig production /". Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5712-2.pdf.
Texto completoWise, Lesley Hilary. "Meta-analysis of genetic studies for complex diseases". Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325514.
Texto completoZouk, Hana. "Functional characterization of novel genetic loci associated with type 1 diabetes". Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116897.
Texto completoLe diabète de type 1 (DT1) est une maladie auto-immune où les cellules bêta, productrices de l'insuline, sont détruites par le système immunitaire. Cette maladie dont l'étiologie est complexe, implique à la fois des facteurs génétiques et environnementaux. Plus de 40 loci génétiques, où il y a une association avec la variation allélique de plusieurs polymorphismes, ont été montré comme augmentant le risque de DT1. Deux de ces régions les plus importantes sont localisés dans la région chromosomique 2q24.3, qui contient des polymorphismes fonctionnels au niveau du gène IFIH1 dont le rôle est de lier l'ARN double brin (DS) viral pour à la suite induire une réponse interféron de type I (IFN), et dans la région chromosomique 16p13, englobant un seul gène nommé CLEC16A dont la fonction est inconnue. Pour élucider le mécanisme de ces associations, nous avons entrepris des études distinctes pour évaluer le rôle fonctionnel d'un polymorphisme de IFIH1 associé au DT1 et de caractériser le rôle possible de CLEC16A dans l'immunité. Nous avons commencé par étudier le rôle d'un polymorphisme codant, Thr946Ala, du gène IFIH1 associé au DT1 et situé dans un bloc de déséquilibre de liaison (DL) qui comprend trois autres gènes. En raison de l'ampleur du DL dans la région ainsi que la possibilité d'une hétérogénéité génétique, le polymorphisme Thr946Ala IFIH1 pourrait être un marqueur pour un variant qui affecte l'expression du gène IFIH1 ou des autres gènes dans le bloc : GCA, KCNH7 et FAP. Lorsque nous avons testé cette hypothèse, nous n'avons observé aucun effet significatif sur la transcription au niveau du locus IFIH1 dans les tissus les plus pertinents pour le DT1. Nous indiquons également que les allèles protéiniques du polymorphisme d'un seul nucléotide (SNP) Thr946Ala n'ont pas d'effets significatifs sur les niveaux l'IFN-α sécrété suite à une stimulation par le poly I:C, un composé imitant l'ARN double brin. Pris ensemble, ces deux études suggèrent que les mécanismes de l'association observée pour le SNP Thr946Ala restent à déterminer, mais n'impliquent pas la modulation de l'ARNm ou la réponse d'IFN-α via le poly I:C. Pour ce dernier, un échantillonnage plus grand serait nécessaire afin de confirmer cette hypothèse en raison de la grande variabilité observée dans la réponse IFN. Notre dernière étude portait sur la caractérisation de la protéine CLEC16A dont l'expression préférentielle par deux types de cellules présentatrice d'antigènes, suggère un rôle potentiel dans l'immunité. Nous avons donc émis l'hypothèse que CLEC16A pourrait être impliqué dans la co-stimulation et l'activation des lymphocytes T et avons évalué celle-ci dans un modèle indépendant d'un antigène. Nous avons constaté que CLEC16A ne participe pas dans la voie de la co-stimulation, comme en témoigne par l'absence d'effets sur l'activation et la prolifération des lymphocytes T lors de la déplétion de CLEC16A. Nous montrons également que la localisation subcellulaire de CLEC16A est dans le réticulum endoplasmique rugueux (RE). Nos résultats mettent en évidence la difficulté qu'est de faire la transition à partir d'associations génétiques avec le DT1 vers des études fonctionnelles, qui sont essentielles pour pouvoir faire le pont entre la prédisposition génétique et les mécanismes biologiques qui sous-tendent le dysfonctionnement immunitaire associé au DT1. Toutes les hypothèses devront être examinées et écartées une par une jusqu'à ce que le mécanisme réel soit découvert.
Zhang-Barber, Li. "Characterisation of genetic loci of Salmonella typhimurium involved in growth inhibition". Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338933.
Texto completoQuaranta, Maria. "A molecular genetic analysis of Crohn's disease susceptibility loci in psoriasis". Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/a-molecular-genetic-analysis-of-crohns-disease-susceptibility-loci-in-psoriasis(bd43230e-4836-4a73-84e7-0da4212eb834).html.
Texto completoWestbury, Sarah Kate. "Mechanisms in heamopietic differentiation : insights from novel loci in genetic thrombocytopenia". Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.752731.
Texto completoAlbagha, Omar M. E. "Investigation and characterisation of loci influencing the genetic susceptibility to osteoporosis". Thesis, University of Aberdeen, 2001. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU534859.
Texto completoCarlborg, Örjan. "New methods for mapping quantitative trait loci /". Uppsala : Dept. of Animal Breeding and Genetics, Swedish Univ. of Agricultural Sciences ([Institutionen för husdjurens genetik], Sveriges lantbruksuniv.), 2002. http://projkat.slu.se/SafariDokument/210.htm.
Texto completoReed, Peter Wayne. "Genetic analysis of Type 1 (insulin-dependent) diabetes mellitus". Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325788.
Texto completoEvenstone, Lauren. "Employing Limited Next Generation Sequence Data for the Development of Genetic Loci of Phylogenetic and Population Genetic Utility". FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2191.
Texto completoZhu, Guohua. "Ascertainment in two-phase sampling designs for segregation and linkage analysis /". Connect to text online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1112844349.
Texto completo[School of Medicine] Department of Epidemiology and Biostatistics. Includes bibliographical references. Available online via OhioLINK's ETD Center.
Newbury, Dianne F. "A genome wide screen for loci involved in specific language impairment". Thesis, University of Oxford, 2002. http://ora.ox.ac.uk/objects/uuid:2b30517a-cecd-49f3-8a5d-556cef6d6723.
Texto completoShen, Xia. "Novel Statistical Methods in Quantitative Genetics : Modeling Genetic Variance for Quantitative Trait Loci Mapping and Genomic Evaluation". Doctoral thesis, Uppsala universitet, Beräknings- och systembiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-170091.
Texto completoOverall, Andrew David James. "The geographic scale of human genetic variation at short tandem repeat loci". Thesis, Queen Mary, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325035.
Texto completoLiu, Yan Tat. "Detection of genetic variation in the human α- and β-globin loci". Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433372.
Texto completoLu, Yue. "Genetic mapping of quantitative trait loci for slow-rusting traits in wheat". Diss., Kansas State University, 2016. http://hdl.handle.net/2097/32179.
Texto completoDepartment of Agronomy
Guihua Bai
Allan K. Fritz
Wheat leaf rust, caused by Puccinia triticina, is an important fungal disease worldwide. Growing resistant cultivars is an effective practice to reduce the losses caused by the disease, and using slow-rusting resistance genes can improve the durability of rust resistance in the cultivars. CI13227 is a winter wheat line that shows a high level of slow-rusting resistance to leaf rust and has been studied extensively. In this research, two recombinant inbreed line (RIL) populations derived from CI13227 x Suwon (104 RILs) and CI13227 x Everest (184 RILs) and one doubled haploid (DH) population derived from CI13227 x Lakin with 181 lines were used to identify quantitative trait loci (QTLs) for slow leaf rusting resistance. Each population and its parents were evaluated for slow-rusting traits in two greenhouse experiments. A selected set of 384 simple sequence repeat markers (SSRs), single nucleotide polymorphism markers (SNPs) derived from genotyping-by-sequencing (GBS-SNPs) or 90K-SNP chip (90K-SNPs) were analyzed in the three populations. Six QTLs for slow-rusting resistance, QLr.hwwgru-2DS, QLr.hwwgru-7BL, QLr.hwwgru-7AL, QLr.hwwgru-3B_1, QLr.hwwgru-3B_2, and QLr.hwwgru-1D were detected in the three populations with three stable QTLs, QLr.hwwgru-2DS, QLr.hwwgru-7BL and QLr.hwwgru-7AL. These were detected and validated by Kompetitive Allele-Specific PCR (KASP) markers converted from GBS-SNPs and 90K-SNPs in at least two populations. Another three QTLs were detected only in a single population, and either showed a minor effect or came from the susceptible parents. The KASP markers tightly linked to QLr.hwwgru-2DS (IWB34642, IWB8545 and GBS_snpj2228), QLr.hwwgru-7BL (GBS_snp1637 and IWB24039) and QLr.hwwgru-7AL (IWB73053 and IWB42182) are ready to be used in marker-assisted selection (MAS) to transfer these QTLs into wheat varieties to improve slow-rusting resistance in wheat.
Stone, Hillarey. "Enrichment of Transcriptional Regulators at Steroid Sensitive Nephrotic Syndrome Genetic Risk Loci". University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin160199291391191.
Texto completoPreston, E. Lynn. "Isolation and Characterization of Polymorphic Loci from the Caribbean Flamingo (Phoenicopterus ruber ruber): New Tools for Wildlife Management". Thesis, University of North Texas, 2005. https://digital.library.unt.edu/ark:/67531/metadc4908/.
Texto completoSilva, Heyder Diniz. "Aspectos biométricos da detecção de QTL'S ("Quantitative Trait Loci") em espécies cultivadas". Universidade de São Paulo, 2001. http://www.teses.usp.br/teses/disponiveis/11/11134/tde-18102002-162652/.
Texto completoIn general terms, QTL mapping di®ers from other research ac-tivities in genetics. Being basically a multiple test procedure, problems arise which are related to the joint level of signi¯cance of the analysis, and consequently, to its power. Using computational simulation of data, the power of simple marker analysis, carried out through multiple linear regression, using stepwise procedures to select the markers was obtained. Procedures based on single tests, using both the FDR and the Bonferroni criteria to determinate the joint level of signi¯cance were also used. Results showed that the procedure based on multiple regression, using the stepwise technique, was the most powerful in identifying markers associated to QTL's. However, in cases where its power was smaller, its advantage was the ability to detect only markers strongly associates with QTL's. In comparision with the Bonferroni method, the FDR criterion was in general more powerful, and should be adopted in the interval mapping procedures. Additional problems found in the QTL analysis refer to the QTL x environment interaction. We consider this aspect by par-titioning the genotype x environment interaction variance in components explained by the molecular markers and deviations. This alowed estimating the proportion of the genetic variance (pm), and genotype x environment variance (pms), explained by the markers. These estimators are not a®ected by deviations of allelic frequencies of the markers in relation to the expected values (1:2:1 in a F2 generation, 1:1 in a backcross , etc). However, there is a high probability of obtaining estimates out of the parametric range, specially for high values of this proportion. Nevertheless, these probabilities can be reduced by increasing the number of replications and/or environments where the progenies are evaluated. Based on a set of grain yield data, obtained from the evaluation of 68 maize progenies genotyped for 77 codominant molecular markers, and evaluated as top crosses in four environments, the presented methodologies allowed estimating proportions pm and pms as well the classification of markers associated to QTL's, with respect to its level of genotype x environment interaction. The procedure also allowed the identification of chromosomic regions, involved in the genetical control of the considered trait, according to its stability, in relation to the observed environmental variation.
Saunders, Barbara Ann. "Investigation of the inheritance of RAPD loci in Daphnia Pulex /". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0002/MQ42439.pdf.
Texto completoAntonella, Galvan. "Mapping of loci providing genetic resistance to tumorigenesis and characterization of candidate genes". Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491913.
Texto completoBaron, Gerald Stephen. "Isolation and characterization of two genetic loci from the intracellular pathogen Francisella novicida". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ36628.pdf.
Texto completoSieh, Weiva. "Genetic susceptibility to prostate cancer : the androgen receptor and prostate-specific antigen loci /". Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/10875.
Texto completoSelladurai, Surendran. "Genetic mapping and molecular characterisation of Russian wheat aphid resistance loci in wheat". Thesis, Selladurai, Surendran (2016) Genetic mapping and molecular characterisation of Russian wheat aphid resistance loci in wheat. PhD thesis, Murdoch University, 2016. https://researchrepository.murdoch.edu.au/id/eprint/33781/.
Texto completoMorona, Judy Kay. "Characterisation of the capsular polysaccharide biosynthesis loci of streptococcus pneumoniae serogroup 19 /". Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phm8678.pdf.
Texto completoDierks, Claudia. "Molecular genetic analysis of quantitative trait loci (QTL) for osteochondrosis in Hanoverian warmblood horses". [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980656702.
Texto completoRoca, Ayats Neus. "Identification and functional characterization of genetic loci involved in osteoporosis and atypical femoral fracture". Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668311.
Texto completoZhu, Hong. "Genetic and expression analysis of candidate tumor loci in non-small cell lung cancer". Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B35328368.
Texto completoMikko, Sofia. "A comparative analysis of genetic diversity at Mhc DRB loci in some ruminant species /". Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1997. http://epsilon.slu.se/avh/1997/91-576-5237-6.gif.
Texto completoCase, Richard Alan James. "Population genetic structure of Atlantic cod (Gadus morhua) : applications of neutral and selected loci". Thesis, University of Hull, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440646.
Texto completoZhu, Hong y 朱紅. "Genetic and expression analysis of candidate tumor loci in non-small cell lung cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B35328368.
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