Literatura académica sobre el tema "Flexibilité de l'ARN"
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Artículos de revistas sobre el tema "Flexibilité de l'ARN"
Zbinden, Luc. "L'ART : écho de l'indicible - un projet interdisciplinaire novateur". Didactica Historica 7, n.º 1 (2021): 177–83. http://dx.doi.org/10.33055/didacticahistorica.2021.007.01.177.
Texto completoCypess, Rebecca. "‘It Would Be without Error’: Automated Technology and the Pursuit of Correct Performance in the French Enlightenment". Journal of the Royal Musical Association 142, n.º 1 (2017): 1–29. http://dx.doi.org/10.1080/02690403.2017.1286115.
Texto completoPasset, Olivier. "Allemagne : la nouvelle frontière". Revue de l'OFCE 32, n.º 3 (1 de junio de 1990): 27–71. http://dx.doi.org/10.3917/reof.p1990.32n1.0027.
Texto completoTesis sobre el tema "Flexibilité de l'ARN"
Panei, Francesco Paolo. "Advanced computational techniques to aid the rational design of small molecules targeting RNA". Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS106.
Texto completoRNA molecules have recently gained huge relevance as therapeutic targets. The direct targeting of RNA with small molecule drugs emerges for its wide applicability to different classes of RNAs. Despite this potential, the field is still in its infancy and the number of available RNA-targeted drugs remains limited. A major challenge is constituted by the highly flexible and elusive nature of the RNA targets. Nonetheless, RNA flexibility also presents unique opportunities that could be leveraged to enhance the efficacy and selectivity of newly designed therapeutic agents. To this end, computer-aided drug design techniques emerge as a natural and comprehensive approach. However, existing tools do not fully account for the flexibility of the RNA. The project of this PhD work aims to build a computational framework toward the rational design of compounds targeting RNA. The first essential step for any structure-based approach is the analysis of the available structural knowledge. However, a comprehensive, curated, and regularly updated repository for the scientific community was lacking. To fill this gap, I curated the creation of HARIBOSS ("Harnessing RIBOnucleic acid - Small molecule Structures"), a database of all the experimentally-determined structures of RNA-small molecule complexes retrieved from the PDB database. HARIBOSS is available via a dedicated web interface (https://hariboss.pasteur.cloud), and is regularly updated with all the structures resolved by X-ray, NMR, and cryo-EM, in which ligands with drug-like properties interact with RNA molecules. Each HARIBOSS entry is annotated with physico-chemical properties of ligands and RNA pockets. HARIBOSS repository, constantly updated, will facilitate the exploration of drug-like compounds known to bind RNA, the analysis of ligands and pockets properties and, ultimately, the development of in silico strategies to identify RNA-targeting small molecules. In coincidence of its release, it was possible to highlight that the majority of RNA binding pockets are unsuitable for interactions with drug-like molecules, attributed to the lower hydrophobicity and increased solvent exposure compared to protein binding sites. However, this emerges from a static depiction of RNA, which may not fully capture their interaction mechanisms with small molecules. In a broader perspective, it was necessary to introduce more advanced computational techniques for an effective accounting of RNA flexibility in the characterization of potential binding sites. In this direction, I implemented SHAMAN, a computational technique to identify potential small-molecule binding sites in RNA structural ensembles. SHAMAN enables the exploration of the target RNA conformational landscape through atomistic molecular dynamics. Simultaneously, it efficiently identifies RNA pockets using small probe compounds whose exploration of the RNA surface is accelerated by enhanced-sampling techniques. In a benchmark encompassing diverse large, structured riboswitches as well as small, flexible viral RNAs, SHAMAN accurately located experimentally resolved pockets, ranking them as preferred probe hotspots. Notably, SHAMAN accuracy was superior to other tools working on static RNA structures in the realistic drug discovery scenario where only apo structures of the target are available. This establishes SHAMAN as a robust platform for future drug design endeavors targeting RNA with small molecules, especially considering its potential applicability in virtual screening campaigns. Overall, my research contributed to enhance our understanding and utilization of RNA as a target for small molecule drugs, paving the way for more effective drug design strategies in this evolving field
LEGER, JEAN-FRANCOIS. "L'adn : une flexibilite structurale adaptee aux interactions avec les autres macromolecules de son environnement". Université Louis Pasteur (Strasbourg) (1971-2008), 1999. http://www.theses.fr/1999STR13094.
Texto completoPONCIN, MARC. "Modelisation theorique de la structure fine et de la flexibilite de l'adn en fonction de la sequence". Paris 7, 1991. http://www.theses.fr/1991PA077072.
Texto completoAbi, Ghanem Joséphine. "Contribution à l'étude de la flexibilité de l'ADN et à son rôle dans l'interaction non spécifique DNase I/ADN". Paris 6, 2009. http://www.theses.fr/2009PA066316.
Texto completoCuruksu, Jeremy. "Conformational sampling by molecular mechanics and dynamics simulations applied to the flexibility of Nucleic acid". Paris 7, 2009. http://www.theses.fr/2009PA077013.
Texto completoMy PhD dissertation deals with the application of atomic-scale computer simulation (Molecular Dynamics) on different aspects of the conformational flexibility of Nucleic Acids. I have used diverse statistical and computational methods such as Umbrella Sampling and Replica Exchange to extract entropic properties, e. G. Free energy, characterising (i) the bending of DNA on short length-scale, (ii) the folding of recently discovered RNA ribosomal motifs (the kink-tum motif) and (iii) backbone dihedral conformations accessible to damaged DNA. One achievement is the reproduction of the experimental curve for the probability of very high bend angles observed for short fragment of DMA which demonstrates a non linear (softer) bending flexibility of DMA. Indeed the results of my thesis predict that DMA kinks (local defects unstacking neighbour basepairs) occur in vivo and some of them induce a 90°-turn in the hélix. They are associated with a systematic decrease of the local DMA stiffness constant (half an order of magnitude) which was quite unexpected. DNA bending up to 150° on the 5 nm length scale requires on average 12 kcal/mol. It is slightly less expensive, -10 kcal/mol when a run of consecutive adenines is present. Methodological development of Hamiltonian replica exchange sampling techniques enables to characterize several competing DNA backbone conformations accessible to damaged DNA (an abasic site). More generally the PhD thesis presents the development of new methods to tackle the accurate sampling of particular nucleic acid helical propensities, and this is closed with a brief section on an original effort to create a self-learning approach in the context of replica exchange sampling with molecular dynamics
MILHE, CATHERINE. "Flexibilite de l'adn : etude par rmn d'oligonucleotides en solution. structure et dynamique de points chauds de mutagenese et dynamique de la sequence consensus d'un promoteur". Université Louis Pasteur (Strasbourg) (1971-2008), 1994. http://www.theses.fr/1994STR13137.
Texto completoPakleza, Christophe. "Méthodologies du repliement de l'ADN à différentes échelles : modélisation moléculaire des épingles à cheveux à partir de la théorie de l'élasticité et de contraintes RMN : analyse et mesure de la courbure et de la flexibilité à partir de microscopies". Paris 6, 2002. http://www.theses.fr/2002PA066283.
Texto completoBarbe, Sophie. "Modulation de l'interaction intégrase/ADN du VIH-1 par des dérivés des styrylquinoléines et par la modification de nucléotides". Phd thesis, École normale supérieure de Cachan - ENS Cachan, 2006. http://tel.archives-ouvertes.fr/tel-00129455.
Texto completoMassicotte, Rachel. "L'épigénétique, moteur de l'évolution d'un vertébré asexué". Thèse, 2011. http://hdl.handle.net/1866/6259.
Texto completoThe aim of the thesis is to determine the extent of epigenetic variation, more specifically DNA methylation polymorphism, not linked to genetic variation in natural populations of an asexual vertebrate. This evaluation enables to better understand the importance that plays epigenetics processes in ecology and evolution. The biological model used is the clonal hybrid of the gynogenetic Chrosomus eos-neogaeus complex. Even in absence of genetic difference, an important phenotypic variability is observed among hybrids of the same clonal lineage living in different environments. Epigenetics, a modification of genes expression without a change at the DNA sequence, provides an explanation to this paradox. The diversity of phenotypes may be explained by differential methylation patterns of genes and/or alleles among genetically identical hybrids. The diversity of epiclonal lineages may be explained by the colonisation of many epiclonal lineages, established in response to the environment or stochastically. Many methods were used for screening the genome of clonal hybrids in order to highlight DNA methylation polymophism at the scale of an individual and among individuals of different populations.