Literatura académica sobre el tema "Famille M1"
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Artículos de revistas sobre el tema "Famille M1"
Aslan, Nuray, Levi Watkin, Jonila Pishtari, Huiqing Xu, John L. Sullivan y Katherine Luzuriaga. "Expansion of influenza M1-specific memory cells cross-reactive with Epstein-Barr Virus (EBV) lytic epitopes correlates with severity of EBV-induced infectious mononucleosis (130.14)". Journal of Immunology 182, n.º 1_Supplement (1 de abril de 2009): 130.14. http://dx.doi.org/10.4049/jimmunol.182.supp.130.14.
Texto completoPaul, Kathleen, Christopher Stojanowski, Toby Hughes, Alan Brook y Grant Townsend. "Genetic Correlation, Pleiotropy, and Molar Morphology in a Longitudinal Sample of Australian Twins and Families". Genes 13, n.º 6 (2 de junio de 2022): 996. http://dx.doi.org/10.3390/genes13060996.
Texto completoBERGMAN, GEORGE M. "ON COMMON DIVISORS OF MULTINOMIAL COEFFICIENTS". Bulletin of the Australian Mathematical Society 83, n.º 1 (13 de octubre de 2010): 138–57. http://dx.doi.org/10.1017/s0004972710001723.
Texto completoSalomon, Emmanuel, Marjorie Schmitt, Anil Marapaka, Athanasios Stamogiannos, Germain Revelant, Céline Schmitt, Sarah Alavi et al. "Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases". Molecules 23, n.º 10 (11 de octubre de 2018): 2607. http://dx.doi.org/10.3390/molecules23102607.
Texto completoPascual Alonso, Isel, Fabiola Almeida García, Mario Ernesto Valdés Tresanco, Yarini Arrebola Sánchez, Daniel Ojeda del Sol, Belinda Sánchez Ramírez, Isabelle Florent, Marjorie Schmitt y Francesc Xavier Avilés. "Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families". Marine Drugs 21, n.º 5 (28 de abril de 2023): 279. http://dx.doi.org/10.3390/md21050279.
Texto completoMcClain, Mark S., Ping Cao, Hideki Iwamoto, Arlene D. Vinion-Dubiel, Gabor Szabo, Zhifeng Shao y Timothy L. Cover. "A 12-Amino-Acid Segment, Present in Type s2 but Not Type s1 Helicobacter pylori VacA Proteins, Abolishes Cytotoxin Activity and Alters Membrane Channel Formation". Journal of Bacteriology 183, n.º 22 (15 de noviembre de 2001): 6499–508. http://dx.doi.org/10.1128/jb.183.22.6499-6508.2001.
Texto completoVasko, V. O. y V. V. Kyrychenko. "Induced Mutagenesis for the Creation of New Starting Material in Sunflower Breeding". Helia 42, n.º 70 (26 de julio de 2019): 17–36. http://dx.doi.org/10.1515/helia-2017-0024.
Texto completoPascual Alonso, Isel, Laura Rivera Méndez, Mario E. Valdés-Tresanco, Lotfi Bounaadja, Marjorie Schmitt, Yarini Arrebola Sánchez, Luis Alvarez Lajonchere, Jean-Louis Charli y Isabelle Florent. "Biochemical evidences for M1-, M17- and M18-like aminopeptidases in marine invertebrates from Cuban coastline". Zeitschrift für Naturforschung C 75, n.º 11-12 (26 de noviembre de 2020): 397–407. http://dx.doi.org/10.1515/znc-2019-0169.
Texto completoStrobel, Sonja, Stefan Bereswill, Peter Balig, Peter Allgaier, Hans-Günther Sonntag y Manfred Kist. "Identification and Analysis of a NewvacA Genotype Variant of Helicobacter pylori in Different Patient Groups in Germany". Journal of Clinical Microbiology 36, n.º 5 (1998): 1285–89. http://dx.doi.org/10.1128/jcm.36.5.1285-1289.1998.
Texto completoPerez-Perez, Guillermo I., Richard M. Peek, John C. Atherton, Martin J. Blaser y Timothy L. Cover. "Detection of Anti-VacA Antibody Responses in Serum and Gastric Juice Samples Using Type s1/m1 and s2/m2 Helicobacter pylori VacA Antigens". Clinical Diagnostic Laboratory Immunology 6, n.º 4 (1 de julio de 1999): 489–93. http://dx.doi.org/10.1128/cdli.6.4.489-493.1999.
Texto completoTesis sobre el tema "Famille M1"
Al-Masri, Mounir. "Conception, synthèse et évaluation des dérivés d'aminobenzosubérone comme inhibiteurs potentiels des aminopeptidases de la famille M1". Thesis, Mulhouse, 2017. http://www.theses.fr/2017MULH2862.
Texto completoAminopeptidases of the M1 family are proteases that catalyze the hydrolysis of a peptide bond in the N-terminal position. These are metalloproteases with a zinc ion in their active site conserved in all members of this protein family. These enzymes are involved in many normal physiological processes, but also in metabolic disorders, such as tumor progression, autoimmune diseases, as well as in viral, bacterial and parasitic infections. For these reasons, these aminopeptidases are considered potential therapeutic targets for treating or diagnosing various diseases. In 2006, the laboratory discovered the powerful and selectively inhibiting 3-amino-2-benzosuberone molecular chassis and one of the members of this family of aminopeptidases, namely the APN. The design and synthesis of derivatives of this molecular chassis as potential and selective inhibitors for five other members of the M1 family (APN, ERAP1 / 2, IRAP and PfA-M1) is at the heart of this work. Pharmacological, pharmacokinetic and preclinical studies have been conducted and their results will be presented in the case of PfA-M1 inhibition
Pham, Viet-Laï. "Aminopeptidase B : modélisation moléculaire et étude du site actif par mutagenèse dirigée". Paris 6, 2007. http://www.theses.fr/2007PA066546.
Texto completoAminopeptidase B (Ap-B ; EC 3. 4. 11. 6) cleaves basic residues at the N-terminus of peptides and participates in hormone and neuropeptide processing through an original mechanism recently described. The only known physiological substrate of Ap-B is the glucagon, which is processed into miniglucagon by NRD convertase and Ap-B. In mammals, these hormones are involved in the regulation of glucose homeostasis. One second characteristic of Ap-B is that the enzyme exhibits, in vitro, a residual ability to hydrolyze leukotriene A4 (LTA4) into the pro-inflammatory lipid mediator leukotriene B4. Inversely, LTA4 hydrolase (LTA4H ; EC 3. 3. 2. 6), the closest homologous protein of Ap-B, possesses, besides an epoxyde hydrolase activity, an aminopeptidase activity of broader specificity. Both proteins belong to the M1 family of Zn2+-aminopeptidases. A structure-function analysis is needed for a detailed understanding of the enzymatic mechanisms of Ap-B and to aid in the design of inhibitors, which could be used to determine its whole in vivo functions. In order to carry out a functional analysis by site-directed mutagenesis, we developed an expression system and a purification procedure of Ap-B using E. Coli. Amino acid residues potentially involved in the aminopeptidase activity are identified using alignments of primary structures of proteins from the M1 family. This study allowed us to identify 3 distinct M1 sub-families. This M1 family is characterized by the presence of a HEXXHXn=18E Zn2+- binding motif. Mutations of these residues lead to a total loss of activity and confirm their essential roles in catalysis. The major part of the M1 family members (Ap-B, LTA4H,…) constitutes the main sub-family and possesses a second consensus motif (GXMEN). Mutations of the M, E or N residues also lead to a total loss of aminopeptidase activity. Surprisingly, replacement of the conserved glycine into a serine or a proline created two new active enzymes. The G298S mutant exhibits properties similar to the wild type enzyme, whereas the G298P mutant shows a modification of its substrate specificity (recognizing R, K, P and A), its inhibition profile and its behavior towards Cl-. Fluorescence spectroscopy and circular dichroïsm analyses did not show any fundamental modification in the mutant structures. Ten other residues were mutated in the Ap-B primary structure and their functional studies are in progress. The sequence and catalytic similarities shared between Ap-B and LTA4H and the determination of the X-ray structure of LTA4H led us to build a 3D structural model of Ap-B. This model was used, on one hand, to better understand the enzymatic role of the glycine residue of the GXMEN motif and, on the other hand, to highlight functional differences between Ap-B and LTA4H, particularly at the level of their active site and of their proteinprotein interaction properties. In parallel, we also developed a second system of expression and purification of Ap-B using baculovirus and insect cells. This system allows us to purify a sufficient amount of protein for crystallogenesis assays
Anujith, Kumar K. V. "Peptidase N, A Major Aminopeptidase Belonging To The M1 Family : Biochemical And Functional Implications". Thesis, 2007. https://etd.iisc.ac.in/handle/2005/583.
Texto completoAnujith, Kumar K. V. "Peptidase N, A Major Aminopeptidase Belonging To The M1 Family : Biochemical And Functional Implications". Thesis, 2007. http://hdl.handle.net/2005/583.
Texto completoBhosale, Manoj. "Studies On The Functional Roles Of Peptidase N, A M1 Family Member, During Stress And Infection". Thesis, 2011. https://etd.iisc.ac.in/handle/2005/2367.
Texto completoBhosale, Manoj. "Studies On The Functional Roles Of Peptidase N, A M1 Family Member, During Stress And Infection". Thesis, 2011. http://hdl.handle.net/2005/2367.
Texto completoFilipe, Maria Isabel Morais Cardoso Ribeiro. "Innovation in family businesses: a case study of GLSA". Master's thesis, 2019. http://hdl.handle.net/10071/19493.
Texto completoAtualmente, num mundo onde a competição pela presença no mercado é destemida, a inovação torna-se essencial para as empresas sobreviverem e prosperarem. Dado que a maioria das empresas em todo o mundo são familiares, é importante entender como as mesmas agem no que diz respeito à inovação Para muitas empresas familiares em todo o mundo, a inovação é um fator de distinção, que lhes permite perlongar por várias gerações. Neste contexto, o principal objetivo da presente dissertação é entender até que ponto as empresas familiares são de fato mais inovadoras do que o outro tipo de empresa e a sua capacidade de inovar. Para esse fim, a revisão de literatura, num primeiro estágio, abordará a relação da empresa familiar com a inovação, analisando diferentes posições na literatura sobre a vontade e a capacidade deste tipo de empresa inovar. Num segundo estágio, é apresentado o estudo sobre uma empresa familiar - a empresa GL - para fornecer um exemplo prático de uma empresa familiar inovadora. Com o objetivo de apresentar uma perspetiva interna da postura da empresa em relação à inovação, foram realizadas entrevistas a dois membros da família de gerações diferentes. A análise qualitativa das entrevistas forneceu informações práticas sobre como a GL se comporta relativamente à inovação, aplicando os conceitos-chave expostos na revisão de literatura à realidade da empresa. Os aspetos teóricos da presente tese combinados com o estudo de caso da GL pretendem fornecer uma abordagem abrangente para as questões relacionadas aos processos de inovação nas empresas familiares.
Vieira, João Vitorino. "Descriptive analysis of the impact of family business's in the Portuguese context: AEF universe". Master's thesis, 2019. http://hdl.handle.net/10071/19134.
Texto completoCom este estudo pretende-se realizar uma análise ao universo de associados da Associação das Empresas Familiares de forma a caracterizá-los e estabelecer algumas comparações com o panorama nacional português. No entanto, surge como principal objetivo do estudo, a elaboração de alguns indicadores que ajudem a revelar o impacto que este universo tem no contexto nacional. A abordagem inicial ao tema é iniciada com uma análise aos principais temas em debate no universo académico e de investigação relativamente à temática das empresas familiares e do crescente interesse no estudo da mesma. De forma a completar o enquadramento do tema e as análises produzidas, foi feita uma recolha daquilo que vem sendo debatido, dando enfase ás preocupações, desafios e tendências que este tipo de empresas tem sentido. O confronto entre esses tópicos e os resultados obtidos será o grande alvo de discussão final. Importa referir que os resultados e análises produzidas foram construídas com base em dados de 464 empresas com o objetivo de produzir indicadores que permitissem obter uma análise descritiva mas também de impacto macroeconómico. Assim, foram apresentados valores referentes aos anos de 2010 até 2016, que permitissem obter uma imagem caracterizadora dos sectores de atividade, forma jurídica, localização geográfica, dimensão e performance, das empresas em estudo. A nível do impacto macroeconómico as análises visam tópicos como o Imposto sobre o Rendimento das Pessoas Coletivas, Custos com Pessoal e o Produto Interno Bruto.
Amaral, Ana Filipa Basílio. "Análise do valor de mercado da empresa familiar durante o processo de sucessão". Master's thesis, 2015. http://hdl.handle.net/10071/8953.
Texto completoThis thesis addresses the problematic of succession in family businesses and the effect of the media has, during the succession period, on the company value. The succession is referred, by some authors as the biggest challenge faced by family businesses (Handler, 1994). Statistics show that 65 to 80% of companies, globally, are family-oriented (Ussman, 2004) and that only 30% of these companies survive into the second generation and only 10% into the third (Beckhard & Dyer, 1983). Assuming that the effect created by the news of the succession easily creates instability around the main stakeholders: shareholders, suppliers, customers or employees, among others, this thesis analyses the effect, positive or negative, that the news published by the media about the succession on a family-oriented business group, mainly, Grupo Jerónimo Martins, had on the company’s market value, that is, the share value. The relevance of this approach is justified by the ease and speed of access to information than the market currently provides and that the company can’t always control. In this information and technology era, it’s essential that the companies maintain the marker informed about how it is being handled the company’s process of succession, so that speculations don’t bring instability to the company.
Libros sobre el tema "Famille M1"
Christiansen, Michaeol G. y Richard K. Stucky. Revision of the Wind River Faunas, Early Eocene of Central Wyoming. Part 15. New Nyctitheriidae (?Lipotyphla) with Analysis of the Relationships of North American Taxa. Denver Museum of Nature & Science, 2013. http://dx.doi.org/10.55485/xmjs8079.
Texto completoCapítulos de libros sobre el tema "Famille M1"
Atkins, P. W. "D". En Quanta, 76–94. Oxford University PressOxford, 1991. http://dx.doi.org/10.1093/oso/9780198555735.003.0004.
Texto completoActas de conferencias sobre el tema "Famille M1"
Hallam, NasrEddine y Kok Meng Yew. "Families of fuzzy implication operators within measure M1 and their pseudo-strict". En the 1998 ACM symposium. New York, New York, USA: ACM Press, 1998. http://dx.doi.org/10.1145/330560.330699.
Texto completoFiene, Jonathan P. "The M1: A Custom Mechatronics Platform for Robotics Education". En ASME 2010 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/detc2010-29136.
Texto completoGramasco, Hendrick Henrique Fernandes, Maria Clara Foloni, Rebeca Aranha Barbosa Sousa, Yasmim Nadime José Frigo, Mateus Felipe dos Santos, Guilherme Drumond Jardini Anastácio, Stella de Angelis Trivellato et al. "Chemical thrombolysis with extended 15-hour window in a patient undergoing perfusion CT scan with Rapid CT protocol: a case report". En XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.516.
Texto completoAli, Sy A. y Robert R. Moritz. "Rolls-Royce Power Generation Current Products and New Product Plans". En ASME Turbo Expo 2001: Power for Land, Sea, and Air. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/2001-gt-0393.
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