Tesis sobre el tema "Eukaryotes"
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Clark, Francis. "A computational study of gene structure and splicing in model eukaryote organisms /". St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17395.pdf.
Texto completoPlass, Pórtulas Mireya 1982. "Comparative analysis of splicing in eukaryotes". Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/78124.
Texto completoSplicing is the mechanism by which introns are removed from the pre-mRNA to create a mature transcript. This process is performed by a macromolecular complex, the spliceosome, and involves the recognition of the splicing signals in the premRNA. These signals are not always perfectly recognized, which allows the production of different mature transcripts from a single pre-mRNA through a process called alternative splicing. This process can be regulated by specific protein factors or by other mechanisms that affect the recognition of the splicing signals, such as the secondary structure adopted by the pre-mRNA. In this thesis we have investigated the mechanisms of splicing regulation in eukaryotes using computational approaches. Moreover, we have also studied the relationship that exists between protein factors involved in splicing regulation and splicing signals, and how they have co-evolved across species. Finally, and considering the possibilities that alternative splicing can offer from the evolutionary point of view, he have also analyzed the impact of alternative splicing in gene evolution.
van, Weringh Anna. "Exploring Codon-Anticodon Adaptation in Eukaryotes". Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20303.
Texto completoTakamiya, Minako. "Endocrine disrupting chemical impacts on eukaryotes". Thesis, Cranfield University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487012.
Texto completoPlass, Pórtulas Mireya. "Comparative analysis of splicing in eukaryotes". Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/78124.
Texto completoSplicing is the mechanism by which introns are removed from the pre-mRNA to create a mature transcript. This process is performed by a macromolecular complex, the spliceosome, and involves the recognition of the splicing signals in the premRNA. These signals are not always perfectly recognized, which allows the production of different mature transcripts from a single pre-mRNA through a process called alternative splicing. This process can be regulated by specific protein factors or by other mechanisms that affect the recognition of the splicing signals, such as the secondary structure adopted by the pre-mRNA. In this thesis we have investigated the mechanisms of splicing regulation in eukaryotes using computational approaches. Moreover, we have also studied the relationship that exists between protein factors involved in splicing regulation and splicing signals, and how they have co-evolved across species. Finally, and considering the possibilities that alternative splicing can offer from the evolutionary point of view, he have also analyzed the impact of alternative splicing in gene evolution.
Coulombe-Huntington, Jasmin. "Intron loss and gain in Eukaryotes". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18747.
Texto completoMalgré le fait que les introns furent découverts il y a près de 30 ans, leur origine et leur fonction nous échappent encore. Au cours de cette thèse, je décrirais une méthode qui permet de projeter des introns d'une espèce de référence sur d'autres génomes, basée sur des alignements de génomes complets à plusieurs espèces. Nous avons appliqué cette méthode dans le cadre de deux études distinctes. Premièrement, nous avons étudié les pertes et les gains d'introns chez les mammifères et ensuite chez les Drosophiles. Nous avons projeté les introns humains sur le génome de la souris, du rat et du chien, les introns de la souris sur le génome humain et les introns de la Drosophile melanogaster sur les génomes de 10 autres espèces de Drosophiles complètement séquencées. Cette approche d'ordre génomique nous a permis de comparer la présence ou l'absence de plus de 150,000 introns humains dans quatre espèces de mammifères et plus de 35,000 introns de D. melanogaster dans 11 espèces de drosophiles. Nous avons détecté 122 pertes d'introns chez les mammifères mais aucun gain d'intron. Chez les mouches à fruits, nous avons identifié 1754 pertes d'introns et 213 gains d'introns. Dans les deux études, nous démontrons que les introns perdus sont extrêmement courts et démontrent une similarité relativement élevée entre le site d'épissage au début de l'intron et le site d'épissage à la fin de l'intron. Nous démontrons chez les mammifères les pertes d'introns se produisent de préférence dans des gènes hautement exprimés et de fonctions cruciales à la cellule. Chez les drosophiles nous démontrons que les introns perdus ou gagnés sont délimités par des exons plus longs que la moyenne, ont une distribution de phase plutôt distincte et les pertes démontrent une tendance à se retrouver en groupe à l'intérieur des gènes. Chez les mouches à fruits, il semble que les introns perdus évoluent plus rapidement que la moyenne
Keeley, Anthony John. "Holliday junction processing enzymes in eukaryotes". Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313658.
Texto completoFudenberg, Geoffrey. "Three-Dimensional Chromosome Organization in Eukaryotes". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467516.
Texto completoBiophysics
Akhtar, Mahmood Electrical Engineering & Telecommunications Faculty of Engineering UNSW. "Genomic sequence processing: gene finding in eukaryotes". Publisher:University of New South Wales. Electrical Engineering & Telecommunications, 2008. http://handle.unsw.edu.au/1959.4/40912.
Texto completoEttwiller, Laurence Michele. "Computational investigations into cis-regulation in eukaryotes". Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613876.
Texto completoMoustafa, Ahmed Bhattacharya Debashish. "Evolutionary and functional genomics of photosynthetic eukaryotes". Iowa City : University of Iowa, 2009. http://ir.uiowa.edu/etd/311.
Texto completoMoustafa, Ahmed. "Evolutionary and functional genomics of photosynthetic eukaryotes". Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/311.
Texto completoPonce, Toledo Rafael Isaac. "Origins and early evolution of photosynthetic eukaryotes". Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS047/document.
Texto completoPrimary plastids derive from a cyanobacterium that entered into an endosymbioticrelationship with a eukaryotic host. This event gave rise to the supergroup Archaeplastida whichcomprises Viridiplantae (green algae and land plants), Rhodophyta (red algae) and Glaucophyta. Afterprimary endosymbiosis, red and green algae spread the ability to photosynthesize to other eukaryoticlineages via secondary endosymbioses. Although considerable progress has been made in theunderstanding of the evolution of photosynthetic eukaryotes, important questions remained debatedsuch as the present-day closest cyanobacterial lineage to primary plastids as well as the number andidentity of partners in secondary endosymbioses.The main objectives of my PhD were to study the origin and evolution of plastid-bearing eukaryotesusing phylogenetic and phylogenomic approaches to shed some light on how primary and secondaryendosymbioses occurred. In this work, I show that primary plastids evolved from a close relative ofGloeomargarita lithophora, a recently sequenced early-branching cyanobacterium that has been onlydetected in terrestrial environments. This result provide interesting hints on the ecological setting whereprimary endosymbiosis likely took place. Regarding the evolution of eukaryotic lineages with secondaryplastids, I show that the nuclear genomes of chlorarachniophytes and euglenids, two photosyntheticlineages with green alga-derived plastids, encode for a large number of genes acquired by transfersfrom red algae. Finally, I highlight that SELMA, the translocation machinery putatively used to importproteins across the second outermost membrane of secondary red plastids with four membranes, has asurprisingly complex history with strong evolutionary implications: cryptophytes have recruited a set ofSELMA components different from those present in haptophytes, stramenopiles and alveolates.In conclusion, during my PhD I identified for the first time the closest living cyanobacterium to primaryplastids and provided new insights on the complex evolution that have undergone secondary plastid-bearing eukaryotes
Grünert, Stefan. "Translation initiation in mammalian systems". Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390257.
Texto completoYanow, Stephanie Kim. "Regulation of Cdc18 and Cdt1 restricts S phase to once per cell cycle in the fission yeast Schizosaccharomyces pombe". Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251716.
Texto completoMills, Ian Geoffrey. "Effects of phosphatidylinositol 3-phosphate binding proteins on endosomal dynamics". Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367253.
Texto completoBrown, Susan. "Molecular systematics of Vahlkampfid amoebae". Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363946.
Texto completoGrisdale, Cameron James. "The evolution of RNA processing in reduced eukaryotes". Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50067.
Texto completoScience, Faculty of
Botany, Department of
Graduate
Nesbeth, Darren Nicholas. "Biochemical studies of intracellular trafficking pathways in eukaryotes". Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313830.
Texto completoKawamura, Akane. "Structural investigations of arylamine N-acetyltransferases from eukaryotes". Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418524.
Texto completoRichards, Thomas Adam. "Horizontal gene transfer and the evolution of eukaryotes". Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425896.
Texto completoGlebov, Oleg. "Study of clathrin-independent endocytosis in higher eukaryotes". Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613725.
Texto completoAgić, Heda. "Palaeobiology and diversification of Proterozoic-Cambrian photosynthetic eukaryotes". Doctoral thesis, Uppsala universitet, Paleobiologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265229.
Texto completoPalaeobiology and diversification of Proterozoic-Cambrian photosynthetic eukaryotes
Bhardwaj, Shweta. "Interplay between chromatin conformation and transcription in eukaryotes". Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:7395c490-a296-48e8-b8ca-afd785d516b0.
Texto completoKarlsborn, Tony. "Physiological consequences of Elongator complex inactivation in Eukaryotes". Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125667.
Texto completoBulfoni, Manuel. "Exploring new paradigms of translational control in eukaryotes". Thesis, Sorbonne Paris Cité, 2018. https://theses.md.univ-paris-diderot.fr/Bulfoni_Manuel_2_complete_20181129.pdf.
Texto completoRegulation of protein synthesis is a key regulatory step of gene expression of many cellular processes allowing the cell to quickly adapt to the changing environment including external stimuli and stresses. Most of the translational regulation occurs at the the initiation step when ribosomes are recruited to the mRNAs, by disrupting eIF4F, the complex bound to the 5’ mRNA extremity through eIF4E, or by reducing the availability of the eIF2 ternary complex (eIF2-GTP-Met-tRNAMet). During my thesis I showed how these universal steps are regulated to specifically modulate the translation rates of different mRNAs.We showed that Angel1, an eIF4E interacting protein, is specifically localized to the perinuclear compartment where it regulates mRNA translation of specific mRNAs.We also described a novel RNA operon characterized by the specific binding of Hek2, a yeast hnRNP K-like protein, to a subset of nuclear-pore-encoding mRNAs regulating their translation. Moreover, we showed that Hek2 binding to the mRNA is impeded by the SUMOylation, a post-translational modification which is counteracted by Ulp1, a SUMO-protease. Finally, we reported that perturbation of the nuclear pore integrity by either mutations or stress, induced the accumulation of the SUMOylated form of Hek2. Hek2-SUMO is unable to bind to the mRNAs whose translation is thereby enhanced in a feedback process.In the last part of my thesis, we performed the first ever translatome study of a human pancreatic β cell line in response to glucose stimulation. We report that glucose stimulates translation of a defined set of mRNAs and identified their specific features providing important advances to better understand regulation of gene expression by glucose. Taken together our results allowed us to establish new paradigms of translational regulation
Stanke, Mario. "Gene prediction with a Hidden Markov model". Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=970841310.
Texto completoFisher, Richard James. "Amperometric analysis of exocytosis in adrenal chromaffin cells". Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367144.
Texto completoParikesit, Arli Aditya. "Evolutionary Analysis of the Protein Domain Distribution in Eukaryotes". Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-100869.
Texto completoEhrismann, Dominic. "The biochemical basis of oxygen sensing in higher eukaryotes". Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534193.
Texto completoGossmann, Toni Ingolf. "Investigating genome wide patterns of natural selection in eukaryotes". Thesis, University of Sussex, 2012. http://sro.sussex.ac.uk/id/eprint/43293/.
Texto completoSchmidt, Hugo Gerald. "Does transcription activator diffusion drive gene clustering in eukaryotes?" Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648245.
Texto completoBell, Christian H. "Structural studies of chemotaxis in prokaryotes and higher eukaryotes". Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:94441e35-6b9a-4af9-a113-097e2c5da900.
Texto completoDong, Lin. "Contributions to the Proterozoic and Cambrian Evolution of Eukaryotes". Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/26626.
Texto completoPh. D.
Clever, Beate. "DNA repair in eukaryotes: the Rad54 recombinational repair protein /". [S.l : s.n.], 1996. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Texto completoLange, Anja. "Structural characterization of the interaction of the Stam2's ubiquitin binding domains with ubiquitin chains by NMR : Cooperativity or not, that is the question !" Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10308.
Texto completoFrom the discovery of ubiquitin and its function as signal for proteasomal degradation over 20 years ago to this days, it became evident that ubiquitin is a universal signal in eukaryotic cells. Ubiquitin in its different forms is involved in many versatile cellular processes. Knowing that the ubiquitin signal is differently translated, depending on its occurrences as mono-ubiquitin or poly-ubiquitin, raises the question: how do cells distinguish between the different occurrences of ubiquitin and translate it into the proper response? Proteins interacting with ubiquitin contain so called ubiquitin binding domains (UBDs), whereas the affinities to ubiquitin vary from a few _M to mM. So far only three (K63, K48 and linear chains) out of the eight possible chain-linkages can be produced in sufficient amounts to characterize their interaction with UBDs. K48- and K63- linked ubiquitin chains regulate different cellular events and need to be recognized by different proteins. Thus, it is of prime importance to characterize the binding of different UBDs to these two kinds of ubiquitin chains, as it can give important clues related to the general mechanism of chain discrimination by ubiquitin adapter proteins. Some isolated UBDs exhibit a preference for one chain linkage type over the other, whereas others do not discriminate between mono-ubiquitin or K63- and K48-linked chains. Interestingly, many ubiquitin adapter proteins harbor more than one UBD. STAM2 is a ubiquitin adapter protein, that is involved in endosomal receptor sorting and supposed to preferentially bind mono-ubiquitin and K63- over K48-linked ubiquitin. STAM2 contains two UBDs (a VHS and UIM domain) that were shown to bind to ubiquitin . The current manuscript shows that STAM2’s SH3 domain binds ubiquitin as well. To understand the function of the sequential arrangement of three UBDs in one protein, first binding of the individual VHS and UIM domains to monoubiquitin as well as K48- and K63-linked di-ubiquitin was investigated. This work shows, that the VHS domain displays a different mode of binding for K63- and K48-linked diubiquitin. In spite of the fact, that the apparent Kd for both chains is the same, only one VHS domain can bind to K48-linked di-ubiquitin chains (with a preference for the distal domain), whereas K63-linked di-ubiquitin can accommodate two VHS domains at a time. Since no conclusion can be drawn with respect to the apparent Kds, the different binding modes might gain more impact in consideration of the ensemble of three UBDs. Results presented in this manuscript, based on a construct containing the VHS and UIM domain, show that binding to K63- but not K48-linked di-ubiquitin is cooperative
Haider, Mustafa M. "The intracellular sorting of vacuolar proteins in the yeast Saccharomyces cerevisiae". Thesis, Durham University, 1989. http://etheses.dur.ac.uk/6495/.
Texto completoDay, Deborah Anne. "Regulation of cap-dependent and cap-independent translational initiation in stressed yeast cells". Thesis, University of Kent, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244341.
Texto completoNuttall, M. E. "A study of polyamine acetylation in mammalian cells in culture". Thesis, University of Aberdeen, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234143.
Texto completoCammarano, Rosalia. "Compositional heterogeneity and gene distribution in the genomes of eukaryotes". Thesis, Open University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548071.
Texto completoYao, Xiaoquan. "Sequence features affecting translation initiation in eukaryotes: A bioinformatic approach". Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/27658.
Texto completoHaghighat, Ashkan. "Studies on the mechanisms ofmRNA binding to ribosomes in eukaryotes". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0002/NQ44448.pdf.
Texto completoMorita, shigeru. "Improved methods for production of useful recombinant proteins in eukaryotes". Kyoto University, 2001. http://hdl.handle.net/2433/150355.
Texto completoRajagopal, Abbhirami. "Identification and characterization of HRG-1 heme transporters in eukaryotes". College Park, Md.: University of Maryland, 2008. http://hdl.handle.net/1903/8867.
Texto completoThesis research directed by: Dept. of Cell Biology and Molecular Genetics . Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Pandya, Siddharth. "Directional Selection on Tyrosine Frequences in Eukaryotes Versus Solvent Accessibility". Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/297727.
Texto completoForget, Anthony L. "Homologous Recombinational DNA Repair: from Prokaryotes to Eukaryotes: a Dissertation". eScholarship@UMMS, 2004. https://escholarship.umassmed.edu/gsbs_diss/68.
Texto completoRoger, Andrew J. "Studies on the phylogeny and gene structure of early-branching eukaryotes". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24782.pdf.
Texto completoBakaric, Robert [Verfasser]. "Genomics of Gene Gain and Gene Loss in Eukaryotes / Robert Bakaric". Kiel : Universitätsbibliothek Kiel, 2016. http://d-nb.info/1122438567/34.
Texto completoHaghighat, Ashkan. "Studies on the mechanisms of mRNA binding to ribosomes in eukaryotes". Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=34730.
Texto completoPommier, Yves. "Les agents intercalants affectent le fonctionnement des adn topoisomerases deux eukaryotes". Paris 6, 1986. http://www.theses.fr/1986PA066570.
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