Literatura académica sobre el tema "Éditeurs de base"
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Artículos de revistas sobre el tema "Éditeurs de base"
Sibbald, Timothy, Victoria Handford y Lloyd Kornelsen. "Reconciliation of Philosophical Perspectives to Address Autoethnographic Methodological Concerns". Alberta Journal of Educational Research 66, n.º 4 (24 de diciembre de 2020): 406–17. http://dx.doi.org/10.55016/ojs/ajer.v66i4.56992.
Texto completoMacaud, Amélie. "Humanoïdes Associés, Le Sagittaire, and the Race to Publish Charles Bukowski in France in 1977-1978". Revue française d’études américaines N° 176, n.º 3 (20 de octubre de 2023): 96–112. http://dx.doi.org/10.3917/rfea.176.0096.
Texto completoMailloux, Pierre. "La définition de l’édition et les AACR 2". Documentation et bibliothèques 26, n.º 1 (7 de diciembre de 2018): 29–34. http://dx.doi.org/10.7202/1054264ar.
Texto completoCaby, Jérôme y Géraldine Michel. "Création de valeur des écoles de commerce françaises pour leurs diplômés". Revue Française de Gestion 45, n.º 283 (agosto de 2019): 73–92. http://dx.doi.org/10.3166/rfg.2019.00368.
Texto completoDamian-Gaillard, Béatrice. "Sexuality Stereotypes and Fantasies of Consumers of French Male Heterosexual Pornographic Media." Sur le journalisme, About journalism, Sobre jornalismo 8, n.º 2 (20 de diciembre de 2019): 46–61. http://dx.doi.org/10.25200/slj.v8.n2.2019.401.
Texto completoBussotti, Michela. "Du dictionnaire chinois-latin de Basilio Brollo aux lexiques pour le marché: deux siècles d’édition du chinois en Italie et en France". T’oung Pao 101, n.º 4-5 (7 de diciembre de 2015): 363–406. http://dx.doi.org/10.1163/15685322-10145p04.
Texto completoCrézégut, Anthony. "Sève, éditeur libéral ? Un introducteur des théories critiques". La Pensée N° 415, n.º 3 (6 de septiembre de 2023): 7–15. http://dx.doi.org/10.3917/lp.415.0007.
Texto completoAndrianambinina, F. Ollier D., Patrick O. Waeber, Derek Schuurman, Porter P. Lowry y Lucienne Wilmé. "Clarification on protected area management efforts in Madagascar during periods of heightened uncertainty and instability". Madagascar Conservation & Development 17, n.º 1 (14 de abril de 2023): 25–28. http://dx.doi.org/10.4314/mcd.v17i1.7.
Texto completoKoch, Olivier. "Sécurité et journalisme de guerre". Sur le journalisme, About journalism, Sobre jornalismo 11, n.º 1 (13 de junio de 2022): 60–73. http://dx.doi.org/10.25200/slj.v11.n1.2022.477.
Texto completoBooton, Diane E. "Publishing and Reading Baptista Spagnoli’s Humanist Hagiography in Sixteenth–Century France". Bulletin du bibliophile N° 377, n.º 1 (1 de enero de 2023): 25–42. http://dx.doi.org/10.3917/bubib.377.0035.
Texto completoTesis sobre el tema "Éditeurs de base"
Fontana, Letizia. "Genome and epigenome editing approaches to treat β-hemoglobinopathies". Electronic Thesis or Diss., Université Paris Cité, 2024. http://www.theses.fr/2024UNIP5230.
Texto completoB-thalassemia and sickle cell disease (SCD) result from mutations that affect the synthesis or structure of adult hemoglobin. Historically, allogeneic hematopoietic stem cell (HSC) transplantation from a compatible donor was the only curative treatment. Transplantation of autologous, genetically modified HSCs offers a promising therapeutic alternative for patients lacking a suitable donor. The clinical severity in b-hemoglobinopathies is mitigated by co-inheritance of hereditary persistence of fetal hemoglobin (HPFH), a benign condition characterized by mutations occurring in the genes encoding the fetal y-globin chains, which lead to increased fetal hemoglobin (HbF, a2y2) expression, which can rescue the b-thalassemic and SCD phenotypes. HbF reactivation can be achieved by down-regulating BCL11A, encoding a key repressor of HbF. A CRISPR/Cas9 strategy targeting the GATA1 binding site (BS) within the +58-kb erythroid-specific enhancer of BCL11A has recently been approved as the first gene-editing therapy for b-thalassemia and SCD. Indeed, the targeting of the BCL11A erythroid-specific enhancer led to an efficient reduction of BCL11A in the erythroid cells, without impacting the differentiation of HSPCs in the other cell lineages. However, site-specific nucleases induce double strand breaks (DSBs), posing significant risks, such apoptosis and generation of large genomic rearrangements. In addition, to obtain an adequate number of corrected cells to transplant, several collections of HSCs are necessary to compensate for the cell loss due to DSB-induced apoptosis. Finally, the clinical study showed variability in the extent of HbF reactivation, still high HbS levels and modest correction of ineffective erythropoiesis. Novel CRISPR/Cas9 derived tools are currently available and can be used to develop therapeutic strategies associated with a low risk of DSB generation and increased HbF expression. In this project, we intend to develop universal, safe and efficacious therapeutic strategies for b-hemoglobinopathies aimed at modifying HSCs using base editors (BEs) and epigenome editors to reactivate HbF expression in their erythroid progeny. BEs are a CRISPR-Cas9-based genome editing technology that allows the introduction of point mutations with little DSB generation. In this work we used this technology to inactivate the GATA1 or the ATF4 transcriptional activator BS in the +58-kb and +55-kb BCL11A erythroid-specific enhancers through the insertion of point mutations. In particular, to reach levels of HbF sufficient to rescue the sickling phenotype, we performed simultaneous targeting of the two BS, achieving similar HbF levels compared to CRISPR/Cas9 nuclease-based approach. Additionally, we showed that BEs generated fewer DSBs and genomic rearrangements compared to the CRISPR/Cas9 nuclease approach. In parallel, we developed a novel epigenome-editing strategy aimed at modulating gene expression without altering the DNA sequence (e.g. without generating DSBs). We designed two approaches to upregulate HbF expression: a first strategy targeting and activating the y-globin promoters and a second approach downregulating BCL11A by targeting its erythroid-specific enhancers. We first identified the epigenetic marks in these trans- and cis-regulatory regions that are associated with active or inactive transcription in adult versus fetal erythroid cells. Then we used epigenome editors to deposit active histone modifications at the y-globin promoters and remove inactive marks such as DNA methylation. In parallel, we decorated the BCL11A enhancers with inactive epigenetic marks. Preliminary results demonstrated y-globin reactivation using both strategies, though the effects diminished over time, indicating the need for further optimization. In conclusion, we proposed two different editing approaches that allow to reduce DSB-associate issues as strategies to treat b-hemoglobinopathies
Pauthe, Patricia. "Ever, un éditeur de v-relations". Paris 11, 1985. http://www.theses.fr/1985PA112209.
Texto completoEVER is the interface of the DBMS VERSO. EVER is a full screen V-relation editor. It is window oriented to process V-relations together. EVER is written in the C language and is developed on a SM90 running SMX 4. 3. This thesis presents a method to concept the interface of a software. The application of this method is the editor EVER. A comprehensive description of the editor and the implementation of its main data structures are given
Kabbaj, Younnes el. "MATHUS, un éditeur de relations : contribution à la manipulation des bases de données relationnelles". Paris 11, 1986. http://www.theses.fr/1986PA112279.
Texto completoMathus is a full-screen relational editor. It is used as a user interface of the PEPIN data base management system. It offers a new way to query a data base. The user browses through relations and marks the data he is interested in. In this thesis the functionalities and the implementation of MATHUS are presented. The PEPIN's third version developed to make possible the imp!ementation of MATHUS, is also described
Rougeaux, François-René. "Outils de CAO et conception structurée de systèmes intégrés sur siliciu". Phd thesis, 1987. http://tel.archives-ouvertes.fr/tel-00323949.
Texto completoLibros sobre el tema "Éditeurs de base"
Québec (Province). Direction du matériel didactique., ed. Dévis général de matériel didactique de base, formation générale, primaire-secondaire: Guide à l'intention des éditeurs, des producteurs et des auteurs. Québec, Qué: La Direction, 1985.
Buscar texto completoDevis général de matériel didactique de base formation professionnelle: Guide à l'intention des éditeurs, des producteurs et des auteurs. Québec, Qué: Direction générale du développement pédagogique. Direction du matériel didactique, 1985.
Buscar texto completoCapítulos de libros sobre el tema "Éditeurs de base"
Céard, Jean. "Josse Bade, éditeur de Quintilien à la Renaissance". En Quintilien ancien et moderne, 291–301. Turnhout: Brepols Publishers, 2010. http://dx.doi.org/10.1484/m.latin-eb.4.00064.
Texto completoBeaucé, Pauline, Jeffrey M. Leichman, Olivier Aubert y Françoise Rubellin. "14. Entretien avec Olivier Aubert et Françoise Rubellin. « Comme de la pâte à modeler »". En St Andrews Studies in French History and Culture, 177–86. Cambridge, UK: Open Book Publishers, 2024. http://dx.doi.org/10.11647/obp.0400.14.
Texto completo"Introduction des éditeurs". En Aargau - Basel-Stadt, 15–20. De Gruyter, 2013. http://dx.doi.org/10.1515/9783110291520.15.
Texto completo"Chez le même éditeur". En Pratiquer la Mindfulness Basée sur la Compassion et L'insight (MBCI) en 34 Fiches, II. Elsevier, 2020. http://dx.doi.org/10.1016/b978-2-294-75486-9.00042-5.
Texto completoActas de conferencias sobre el tema "Éditeurs de base"
Lan, R., F. Campana, J. H. Catherine, U. Ordioni y D. Tardivo. "Nouvelles techniques d’aide au diagnostic des lésions pré-cancéreuses et cancéreuses de la cavité orale : revue systématique et résultats préliminaires". En 66ème Congrès de la SFCO. Les Ulis, France: EDP Sciences, 2020. http://dx.doi.org/10.1051/sfco/20206602018.
Texto completoInformes sobre el tema "Éditeurs de base"
Langlais, Pierre-Carl. Bibliométrie. Comité pour la science ouverte, 2024. https://doi.org/10.52949/74.
Texto completoDufour, Quentin, David Pontille y Didier Torny. Contracter à l’heure de la publication en accès ouvert. Une analyse systématique des accords transformants. Ministère de l'enseignement supérieur et de la recherche, abril de 2021. http://dx.doi.org/10.52949/2.
Texto completoLanglais, Pierre-Carl. Infrastructures de science ouverte. Comité pour la science ouverte, 2024. https://doi.org/10.52949/76.
Texto completoGruson-Daniel, Célya y Maya Anderson-González. Étude exploratoire sur la « recherche sur la recherche » : acteurs et approches. Ministère de l'enseignement supérieur et de la recherche, noviembre de 2021. http://dx.doi.org/10.52949/24.
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