Literatura académica sobre el tema "Dynamiques en cellules uniques"
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Artículos de revistas sobre el tema "Dynamiques en cellules uniques"
Dariane, Charles, Manon Baures, Julien Anract, Nicolas Barry Delongchamps, Jacques-Emmanuel Guidotti y Vincent Goffin. "Progéniteurs luminaux prostatiques". médecine/sciences 39, n.º 5 (mayo de 2023): 429–36. http://dx.doi.org/10.1051/medsci/2023058.
Texto completoFischer, Karen Leal, Manon Jaffredo, Jochen Lang y Matthieu Raoux. "Cellules α et β du pancréas". médecine/sciences 37, n.º 8-9 (agosto de 2021): 752–58. http://dx.doi.org/10.1051/medsci/2021111.
Texto completoIsaac, Juliane, Mélodie M. Clerc, François C. Ferré y Benjamin P. J. Fournier. "Les cellules mésenchymateuses orales, une niche spécifique, du développement à la régénération". médecine/sciences 40, n.º 1 (enero de 2024): 24–29. http://dx.doi.org/10.1051/medsci/2023191.
Texto completoRemacle, Françoise y Raphael D. Levine. "Prédiction de la réponse moléculaire à des perturbations mesurée sur des cellules uniques". médecine/sciences 30, n.º 12 (diciembre de 2014): 1129–35. http://dx.doi.org/10.1051/medsci/20143012016.
Texto completoLardenois, A., B. Evrard, A. Suglia, S. Léonard, L. Lesné, I. Coiffec, B. Jégou, S. Mazaud-Guittot, F. Chalmel y A. D. Rolland. "Nouveaux acteurs de la différenciation gonadique normale et pathologique, approches cellules uniques chez l’Homme". Annales d'Endocrinologie 82, n.º 5 (octubre de 2021): 225. http://dx.doi.org/10.1016/j.ando.2021.07.020.
Texto completoFadairo, Muriel, Joseph Kaswengi, Cintya Lanchimba y Eugênio José Silva Bitti. "Protection du capital marque et nouvelles dynamiques géographiques : un travail empirique sur la franchise au Brésil". Recherche et Applications en Marketing (French Edition) 36, n.º 3 (12 de mayo de 2021): 10–28. http://dx.doi.org/10.1177/07673701211009055.
Texto completoGrandjean-Closson, Eva, Camille Heckmann, Corentin Le Coz, Isaline Louvet, Matthieu Neri y Corine Bertolotto. "L’analyse des mélanomes uvéaux primaires à l’aide de la technique de séquençage d’ARN de cellules uniques". médecine/sciences 38, n.º 8-9 (agosto de 2022): 737–39. http://dx.doi.org/10.1051/medsci/2022113.
Texto completoLacoux, C., M. Truchi, J. Fassy, I. Manosalva-Pena, M. Gautier, V. Magnone, K. Lebrigand et al. "Analyse des longs ARN non codants régulés par l’hypoxie dans les cellules d’adénocarcinome pulmonaire à l’aide d’un crible basé sur l’interférence CRISPR sur cellules uniques". Revue des Maladies Respiratoires 40, n.º 2 (febrero de 2023): 122–23. http://dx.doi.org/10.1016/j.rmr.2022.11.029.
Texto completoGoddard, Jean-Christophe. "Fichte or the permanent Aboriginal Revolution". Theoria, Beograd 55, n.º 3 (2012): 45–53. http://dx.doi.org/10.2298/theo1203045g.
Texto completoSadoul, Karin, Clotilde Joubert, Sophie Michallet, Elsie Nolte, Lauralie Peronne, Sacnicté Ramirez-Rios, Anne-Sophie Ribba y Laurence Lafanechère. "Déchiffrage du code tubuline". médecine/sciences 34, n.º 12 (diciembre de 2018): 1047–55. http://dx.doi.org/10.1051/medsci/2018295.
Texto completoTesis sobre el tema "Dynamiques en cellules uniques"
Deprez, Marie. "Étude de l’hétérogénéité cellulaire et des dynamiques de régénération de l’épithélium respiratoire sain par analyses des signatures transcriptionnelles sur cellules uniques". Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://www.theses.fr/2019AZUR6022.
Texto completoImprovements made in nucleic acid sequencing and cell handling technologies now offer the opportunity to analyze simultaneously the content of numerous single cells (RNA, DNA, ...) by global and unbiased approaches. This single-cell ‘omics’ revolution provides a new framework to revisit the “Cell Theory”, elaborated over several centuries, and essentially based on morphological and functional features. The many cell modalities now accessible at single- cell level, such as their transcriptome, spatial localization, developmental trajectories, enrich considerably this definition, and set a renewed context to precisely reassess the definition of ‘cell types’, ‘cell states’ as well as their different interactions and fates.My thesis work initially set up ad hoc approaches and statistical framework to analyze appropriately these single-cell data, which deeply differ from standard bulk RNA-seq. High variance, presence of a huge percentage of null values, large volume of data are among the specific characteristics of these datasets. My work was centered on the main experimental model of my host laboratory, e.g. the human airway epithelium. Human airways are lined by a pseudostratified epithelium mainly composed of basal, secretory, goblet and multiciliated cells. Airways also constitute a true cellular ecosystem, in which the epithelial layer interacts closely with immune and mesenchymal cells. This coordination between cells ensures proper defense of the respiratory system and its correct regeneration in case of external aggression and injuries. A better understanding of the operating sequences in normal and physiopathological situations is relevant in pathologies such as chronic obstructive pulmonary disease, asthma or cystic fibrosis.First, I characterized at a single cell level the precise and cell-specific sequence of events leading to functional regeneration of the epithelium, using a 3D model of human cells. I then built a single-cell atlas of the different cell types that are lining healthy human airways from the nose to the 12th generation of bronchi.By applying computational and statistical approaches, I have identified cell lineage hierarchies and was able to reconstruct a comprehensive cell trajectory roadmap in human airways. I not only confirmed previously described cell lineages, but I have also discovered a novel trajectory that links goblet cells to multiciliated cells, identifying novel cell populations and molecular interactors involved in the process of healthy human airway epithelium regeneration. The profiling of 12 healthy volunteers then generated a dataset of 77,969 cells, derived from 35 distinct locations. The resulting atlas is composed of more than 26 epithelial, immune and stromal cell types demonstrating the cellular heterogeneity present in the airways. Its analysis has revealed a strong proximo-distal gradient of expression in suprabasal, secretory, or multiciliated cells between the nose and lung airways. My work has also improved the characterization of rare cells, including “hillock” cells that have been previously described in mice.In conclusion, this work probably represents one of the first single-cell investigations in human airways. It brings original contributions to our understanding of differentiation’s dynamics and cellular heterogeneity in healthy human airways. The resulting resource will be extremely useful for any future single-cell investigators and also for establishing a very useful joint between clinical and biological works. As such, it will constitute a reference in any future project aiming to precisely analyze specific disease conditions
Bachy, Charles. "Phylogénie, diversité et dynamique temporelle chez les ciliés tintinnidés marins". Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00769949.
Texto completoChalabi, Asma. "Processus d'analyse dynamique pour l'imagerie de cellules vivantes permettant la détection des réponses cellulaires aux anticancéreux, par traitement de l'image et du signal et apprentissage automatique profond". Electronic Thesis or Diss., Université Côte d'Azur, 2024. http://www.theses.fr/2024COAZ6004.
Texto completoCell division and cell death are the main indicators to evaluate cancer drug action, and only their accurate measures can reveal the actual potency and efficacy of a compound. The detection of cell division and cell death events in live-cell assays has the potential to produce robust metrics of drug pharmacodynamics and return a more comprehensive understanding of tumor cells responses to cancer therapeutic combinations. Knowing precisely when a cell death or a cell division occurs in a live-cell experiment allows to study the relative contribution of different drug effects -such as cytotoxic or cytostatic effects, on a cell population. Yet, classical methods require dyes to measure cell viability as an end-point assay with whole population counts, where the proliferation rates can only be estimated when both viable and dead cells are labeled simultaneously.Live-cell imaging is a promising cell-based assay to determine drug efficacies, with the main limitation being the accuracy and depth of the analyses to detect and predict automatically cellular response phenotypes (cell death and division, which share some morphological features).This thesis introduces a method integrating deep learning using neural networks, and image and signal processing to perform dynamic image analyses of single-cell events in time-lapse microscopy experiments of drug pharmacological profiling. This method works by automatically tracking the cells, extracting radiometric and morphologic cell features, and analyzing the temporal evolution of these features for each cell so as to detect cellular events such as division and cell death, as well as acquiring signaling pathway dynamics.A case of study comprising the analyses of caspase-8 single-cell dynamics and other cell responses to cancer drugs is presented. The aim is to achieve automatically, at a large scale the necessary analyses to augment the phenotype prediction method available in the lab (Fateseq) and to apply it to various cancer cell lines of a human cancer cell line panel to improve our live-cell OMICS profiling approaches, and, in a longer term, to scale up pharmacological screening of new cancer drugs
Moussy, Alice. "Caractérisation des premières étapes de différenciation des cellules hématopoïétiques à l'échelle de la cellule unique". Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEP029/document.
Texto completoDespite intensively studies, the fundamental mechanisms of cell fate decision during cellular differentiation still remain unclear. The deterministic mechanisms, often based on studies of large cell populations, cannot explain the difference between individual cell fates choices placed in the same environment. The aim of my thesis work is to study the first steps of hematopoietic cell differentiation at the single cell level thanks to transcriptomic, proteomic and morphological analyses. Two differentiation models have been used: T regulatory lymphocytes and human cord blood-derived CD34+ cells. The behavior of individual cells following stimulation has been analyzed. Using time-lapse microscopy coupled to single cell molecular analyses, we could demonstrate that the cell fate choice is not a unique, programmed event. First, the cell reaches a metastable “multi-primed” state, which is characterized by a mixed lineage gene expression pattern. After transition through an “uncertain”, unstable state, characterized by fluctuations between two phenotypes, the cell reaches a stable state. Our observations are coherent with a stochastic model of cell fate decision. The differentiation is likely to be a spontaneous, dynamic, fluctuating and not a deterministic process. The cell fate decisions are taken by individual cells
Labrunie, Antoine. "Matériaux « uniques » pour cellules solaires organiques mono-composant". Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0044/document.
Texto completoOver the last few years, the development of bulk heterojunction organic solar cells (BHJ OSCs) led to significant increase in photovoltaic (PV) efficiency. Such devices are based on interpenetrated networks of an electron-donor material (D) and an electron-acceptor material (A) constituting the active layer. Nevertheless a careful optimization of the morphology is required to reach high power conversion efficiency. Furthermore, this optimized morphology can evolve towards spontaneous phase segregation which can be detrimental for the PV performances. To circumvent these limitations, a relatively unexplored approach relies on the use of a material where the donor and the acceptor moieties are covalently linked to each other through a nonconjugated π-connector. In this context, the work reported herein describes the synthesis and characterization of various molecular D-σ-A assemblies, as well as their preliminary evaluation as “unique” material for the realisation of single component organic solar cells (SC-OSCs). A first family of dyads and triads, based on quaterthiophene moieties as donor block, was studied. A general methodology to assemble the two D and A blocks via a Huisgen-type click-chemistry is described. Then, in the next chapters, several dyads based on a “push-pull” donor block have been synthesized and characterized. The PV performances of these compounds have been evaluated in SC-OSCs leading to power conversion efficiency up to 1.4 %, a value close to the state of the art
Geisler, Hubert. "Structuration d'hydrogels thermoactivables pour l'analyse de cellules uniques". Electronic Thesis or Diss., Université Paris sciences et lettres, 2020. http://www.theses.fr/2020UPSLS001.
Texto completoWe present in this work a new microfluidic technology aiming at isolating single cells by the use of thermoactuable polymers. One of the polymers we use is polyNIPAM, a polymer that can expand its volume by 400% in water when the temperature is set under 32°C and can shrink down when it is set over 34°C. We use this reversible swelling capability to open and close compartments embedded in a microfluidic chip.Grafting and structuring these hydrogel features relies on thiol-en click chemistry, initiated thermally or by UV irradiation. We have developed methods and microfabrication protocols in order to diversify the substrate materials (from glass to PDMS, COC, PMMA, etc), to expand the structures thickness range (from few microns to a tenth of microns) and to strengthen our knowledge regarding the fabrication impact on the hydrogel’s behavior. A robust protocol of photolithography has finally been worked on allowing the design of any type of 2D features on a large choice of substrates.One of the realistic applications detailed here is the development of microfluidic chips aiming at isolating single cells in hydrogel compartments. (confidential)
Vianay, Benoit. "Adhérence de cellules uniques sur supports micro-structurés". Phd thesis, Grenoble 1, 2009. http://www.theses.fr/2009GRE10329.
Texto completoThe cell adhesion is a critical process involved in many fundamental biological phenomena as dierentiation, tissue repair or cell development. This thesis focuses on a study combining experiments and modelization of single cells spreading on micro-fabricated substrates. Experimental results show that the geometrical constraint imposed by the adhesiveness contrast limits the adhesion. Beyond this limitation, a reproducible organization of the actin cytoskeleton of cells spreading on micro-structured materials suggests that simple physical laws govern the process. We have developed a classication method of basic geometrical shapes observed experimentally to obtain robust statistics. Based on the Cellular Potts model, we reproduced experimental results. This energetical model shows that the basic shapes are metastable states used by cells during spreading. The model parameters are linked to relevant biological parameters. We present results that connect the curvature of interfaces to biological parameters. We show that the experimental measurement of this curvature represents the competition between the contractility of stress bers and the elasticity of the actin gel. A correspondence between the physical properties in the model and the biochemical processes that regulate and organize the cellular adhesion is possible
Vianay, Benoit. "Adhérence de cellules uniques sur supports micro-structurés". Phd thesis, Grenoble 1, 2009. http://tel.archives-ouvertes.fr/tel-00455350.
Texto completoCaccianini, Laura. "Imagerie de l'architecture dynamique de la chromatine dans la cellule unique". Thesis, Paris Sciences et Lettres (ComUE), 2019. https://tel.archives-ouvertes.fr/tel-02896692.
Texto completoChromatin structure and cellular function are tightly linked in the nucleus of mammalian cells. Disruption of chromatin spatial organisation dramatically affects the life of a cell and eventually leads to severe pathologies in entire organisms. Two nuclear factors, CTCF and Cohesin, have been found to play a crucial role in the regulation and maintenance of DNA architecture. Huge advancements have been made in the understanding of the mechanisms behind chromatin arrangement but the field is still lacking a dynamic picture at the single cell and single molecule level. This study provide this study provides insight into the dynamics of CTCF and Cohesin through single particle tracking of CTCF and Cohesin dynamics achieved with single molecule tracking in living mouse embryonic stem cells. The interplay between these two factors was studied by looking at Cohesin’s behaviour in the absence of CTCF and in the context of other biological alterations
Chaste, Julien. "Transistors à nanotube de carbone unique : propriétés dynamiques et électrons uniques". Paris 6, 2009. https://tel.archives-ouvertes.fr/tel-00420915.
Texto completoCapítulos de libros sobre el tema "Dynamiques en cellules uniques"
BONNAFFOUX, Arnaud. "Inférence de réseaux de régulation de gènes à partir de données dynamiques multi-échelles". En Approches symboliques de la modélisation et de l’analyse des systèmes biologiques, 7–50. ISTE Group, 2022. http://dx.doi.org/10.51926/iste.9029.ch1.
Texto completoLONDOÑO-VALLEJO, Arturo. "Évolution et fonctions des télomères". En Fonction et évolution des séquences répétées dans les génomes, 231–63. ISTE Group, 2024. http://dx.doi.org/10.51926/iste.9119.ch5.
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