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Literatura académica sobre el tema "Drug delivery micellar systems"

Autor: Grafiati

Publicado: 10 de marzo de 2023

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Artículos de revistas sobre el tema "Drug delivery micellar systems"

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Demchuk, Zoriana, Mariya Savka, Andriy Voronov, Olga Budishevska, Volodymyr Donchak y Stanislav Voronov. "Amphiphilic Polymers Containing Cholesterol for Drug Delivery Systems". Chemistry & Chemical Technology 10, n.º 4s (25 de diciembre de 2016): 561–70. http://dx.doi.org/10.23939/chcht10.04si.561.

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The interaction of binary copolymers poly(maleic anhydride-co-poly(ethylene glycol) methyl ether methacrylate) with cholesterol results in formation of cholesterol containing polymers, which contain from 4.6 to 46.0 mol % monocholesteryl maleic links. Their structure was confirmed using functional analysis and IR spectroscopy. Acidic and anhydride links of these copolymers form polymeric salts if react with alkali. These salts are surfactants which in aqueous medium form a hierarchy micelles and micellar aggregates depending on the copolymer concentration. Using conductometry it was found that preferably monomolecular micelles are formed in dilute solutions, and micellar aggregates begin to form at higher concentrations. In aqueous media polymeric salts are able to solubilize such lipophilic substances as Sudan III dye and anticancer drug curcumin. Efficiency of solubilization towards Sudan III grows if the content of monocholesteryl maleic fragment in surfactant increases.

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Majumder, Nairrita, Nandita G Das y Sudip K. Das. "Polymeric micelles for anticancer drug delivery". Therapeutic Delivery 11, n.º 10 (octubre de 2020): 613–35. http://dx.doi.org/10.4155/tde-2020-0008.

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Polymeric micelles have gained interest as novel drug delivery systems for the treatment and diagnosis of cancer, as they offer several advantages over conventional drug therapies. This includes drug targeting to tumor tissue, in vivo biocompatibility and biodegradability, prolonged circulation time, enhanced accumulation, retention of the drug loaded micelle in the tumor and decreased side effects. This article provides an overview on the current state of micellar formulations as nanocarriers for anticancer drugs and their effectiveness in cancer therapeutics, including their clinical status. The type of copolymers used, their physicochemical properties and characterization as well as recent developments in the design of functional polymeric micelles are highlighted. The article also presents the design and outcomes of various types of stimuli-responsive polymeric micelles.

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Tănase, Maria Antonia, Adina Raducan, Petruţa Oancea, Lia Mara Diţu, Miruna Stan, Cristian Petcu, Cristina Scomoroşcenco, Claudia Mihaela Ninciuleanu, Cristina Lavinia Nistor y Ludmila Otilia Cinteza. "Mixed Pluronic—Cremophor Polymeric Micelles as Nanocarriers for Poorly Soluble Antibiotics—The Influence on the Antibacterial Activity". Pharmaceutics 13, n.º 4 (24 de marzo de 2021): 435. http://dx.doi.org/10.3390/pharmaceutics13040435.

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In this work, novel polymeric mixed micelles from Pluronic F127 and Cremophor EL were investigated as drug delivery systems for Norfloxacin as model antibiotic drug. The optimal molar ratio of surfactants was determined, in order to decrease critical micellar concentration (CMC) and prepare carriers with minimal surfactant concentrations. The particle size, zeta potential, and encapsulation efficiency were determined for both pure and mixed micelles with selected composition. In vitro release kinetics of Norfloxacin from micelles show that the composition of surfactant mixture generates tunable extended release. The mixed micelles exhibit good biocompatibility against normal fibroblasts MRC-5 cells, while some cytotoxicity was found in all micellar systems at high concentrations. The influence of the surfactant components in the carrier on the antibacterial properties of Norfloxacin was investigated. The drug loaded mixed micellar formulation exhibit good activity against clinical isolated strains, compared with the CLSI recommended standard strains (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29213, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922). P. aeruginosa 5399 clinical strain shows low sensitivity to Norfloxacin in all tested micelle systems. The results suggest that Cremophor EL-Pluronic F127 mixed micelles can be considered as novel controlled release delivery systems for hydrophobic antimicrobial drugs.

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Kim, Kyoung Nan, Keun Sang Oh, Jiwook Shim, Isabel R. Schlaepfer, Sana D. Karam y Jung-Jae Lee. "Light-Responsive Polymeric Micellar Nanoparticles with Enhanced Formulation Stability". Polymers 13, n.º 3 (26 de enero de 2021): 377. http://dx.doi.org/10.3390/polym13030377.

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Light-sensitive polymeric micelles have recently emerged as promising drug delivery systems for spatiotemporally controlled release of payload at target sites. Here, we developed diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles that showed a change in polarity of the micellar core from hydrophobic to hydrophilic under UV light, releasing the encapsulated anti-cancer drug, doxetaxel (DTX). The micelles exhibited a low critical micelle concentration and high stability in the presence of bovine serum albumin (BSA) solution due to the hydrophobic and π–π stacking interactions in the micellar core. Cell studies showed enhanced cytotoxicity of DTX-loaded micellar nanoparticles upon irradiation. The enhanced stability would increase the circulation time of the micellar nanoparticles in blood, and enhance the therapeutic effectiveness for cancer therapy.

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Veselov, Valery V., Alexander E. Nosyrev, László Jicsinszky, Renad N. Alyautdin y Giancarlo Cravotto. "Targeted Delivery Methods for Anticancer Drugs". Cancers 14, n.º 3 (26 de enero de 2022): 622. http://dx.doi.org/10.3390/cancers14030622.

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Several drug-delivery systems have been reported on and often successfully applied in cancer therapy. Cell-targeted delivery can reduce the overall toxicity of cytotoxic drugs and increase their effectiveness and selectivity. Besides traditional liposomal and micellar formulations, various nanocarrier systems have recently become the focus of developmental interest. This review discusses the preparation and targeting techniques as well as the properties of several liposome-, micelle-, solid-lipid nanoparticle-, dendrimer-, gold-, and magnetic-nanoparticle-based delivery systems. Approaches for targeted drug delivery and systems for drug release under a range of stimuli are also discussed.

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Atanase, Leonard Ionut. "Micellar Drug Delivery Systems Based on Natural Biopolymers". Polymers 13, n.º 3 (2 de febrero de 2021): 477. http://dx.doi.org/10.3390/polym13030477.

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The broad diversity of structures and the presence of numerous functional groups available for chemical modifications represent an enormous advantage for the development of safe, non-toxic, and cost-effective micellar drug delivery systems (DDS) based on natural biopolymers, such as polysaccharides, proteins, and peptides. Different drug-loading methods are used for the preparation of these micellar systems, but it appeared that dialysis is generally recommended, as it avoids the formation of large micellar aggregates. Moreover, the preparation method has an important influence on micellar size, morphology, and drug loading efficiency. The small size allows the passive accumulation of these micellar systems via the permeability and retention effect. Natural biopolymer-based micellar DDS are high-value biomaterials characterized by good compatibility, biodegradability, long blood circulation time, non-toxicity, non-immunogenicity, and high drug loading, and they are biodegraded to non-toxic products that are easily assimilated by the human body. Even if some recent studies reported better antitumoral effects for the micellar DDS based on polysaccharides than for commercial formulations, their clinical use is not yet generalized. This review is focused on the studies from the last decade concerning the preparation as well as the colloidal and biological characterization of micellar DDS based on natural biopolymers.

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Pooja Mallya, Gowda D V, Mahendran B, Bhavya M V y Vikas Jain. "Recent developments in nano micelles as drug delivery system". International Journal of Research in Pharmaceutical Sciences 11, n.º 1 (7 de enero de 2020): 176–84. http://dx.doi.org/10.26452/ijrps.v11i1.1804.

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Targeting of the drug directly to the cells, tissues, or organs with no impact on healthy cells is a challenge. In the current era, it's been made possible by therapeutic interventions. The novel drug delivery systems such as nano particulates, liposomes, aquasomes, phytosomes, dendrimers, nano sponges, nano micelles are developed. Nano micelles are developed for efficient targeting and are currently in trend as therapeutic carriers of water-insoluble drugs. Micelles are self-assembling Nano-sized colloidal particles with a hydrophobic core and hydrophilic shell. Among the micelle-forming compounds, amphiphilic copolymers, i.e., polymers consisting of hydrophobic block and hydrophilic block, are gaining increasing attention. Polymeric micelles possess high stability both in vitro and in vivo with good biocompatibility. Nano micelles are used widely because of the smaller size range of 10 to 100nm, with greater drug loading capacity. Advantages over other dosage forms include solubilization of poorly soluble drugs, sustained release, protection of drugs from degradation and metabolism. The property discussed includes CMC, size, and aggregation number, and stability. CMC is the minimum polymer concentration required for micelle formation. Aggregation number (Nₐ) is the number of polymeric chains required to form micelles, and it ranges between tens to hundreds. Thermodynamic stability is based on size, the optical clarity of solution, viscosity, and surface tension. Kinetic stability accounts for micellar integrity. This review will discuss some recent trends in using micelles as pharmaceutical carriers such as to deliver drugs in conditions such as TB, cancer, ocular complications, etc.

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Wang, Jing, Xueqing Xing, Xiaocui Fang, Chang Zhou, Feng Huang, Zhonghua Wu, Jizhong Lou y Wei Liang. "Cationic amphiphilic drugs self-assemble to the core–shell interface of PEGylated phospholipid micelles and stabilize micellar structure". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 371, n.º 2000 (13 de octubre de 2013): 20120309. http://dx.doi.org/10.1098/rsta.2012.0309.

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Since polymeric micelles are promising and have potential in drug delivery systems, people have become more interested in studying the compatibility of polymeric carriers and drugs, which might help them to simplify the preparation method and increase the micellar stability. In this article, we report that cationic amphiphilic drugs can be easily encapsulated into PEGylated phospholipid (PEG–PE) micelles by self-assembly method and that they show high encapsulation efficiency, controllable drug release and better micellar stability than empty micelles. The representative drugs are doxorubicin and vinorelbine. However, gemcitabine and topotecan are not suitable for PEG–PE micelles due to lack of positive charge or hydrophobicity. Using a series of experiments and molecular modelling, we figured out the assembly mechanism, structure and stability of drug-loaded micelles, and the location of drugs in micelles. Integrating the above information, we explain the effect of the predominant force between drugs and polymers on the assembly mechanism and drug release behaviour. Furthermore, we discuss the importance of p K a and to evaluate the compatibility of drugs with PEG–PE in self-assembly preparation method. In summary, this work provides a scientific understanding for the reasonable designing of PEG–PE micelle-based drug encapsulation and might enlighten the future study on drug–polymer compatibility for other polymeric micelles.

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O'driscoll, Caitriona. "Micellar systems for oral drug delivery". Journal of Pharmacy and Pharmacology 50, S9 (septiembre de 1998): 13. http://dx.doi.org/10.1111/j.2042-7158.1998.tb02213.x.

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Biswas, Swati. "Polymeric micelles as drug-delivery systems in cancer: challenges and opportunities". Nanomedicine 16, n.º 18 (agosto de 2021): 1541–44. http://dx.doi.org/10.2217/nnm-2021-0081.

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Tweetable abstract Micelles are nanocarriers for hydrophobic chemotherapeutic drugs. This editorial discusses the current status of preclinical micellar research and sheds light on the possibility of their clinical translation.

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Tesis sobre el tema "Drug delivery micellar systems"

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Mishra, Kaushik. "Folate Receptor-Targeted Polymeric Micellar Nanocarriers as Drug Delivery Systems". University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1629218263972419.

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Rosenbaum, Erik. "Optical characterization of potential drugs and drug delivery systems". Doctoral thesis, Umeå universitet, Kemiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40177.

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This Thesis is a characterization study on substances having potency as drugs as well as on a lipid based drug-delivery matrix. The optical properties of newly synthesized molecules with proven pilicide properties have been characterized with several spectroscopic methods. These methods include optical absorption and fluorescence as well as time-resolved fluorescence. Upon covalently linking compounds with high quantum yields of fluorescence to specific parts of the pilicide, the biological impact was found to increase for some of the derivatives. Furthermore, by expanding the aromatic part of the pilicide molecule, a significant increase in the inherent fluorescence was obtained. The S0-S1 absorption band for these molecules was found to originate from an impure electronic transition, vibronically promoted by intensity borrowing from higher electronic states. Included in this Thesis is the measurement of how deeply some in this class of newly synthesized molecules become situated when placed inside ganglioside GM1 micelles, and how the molecules’ reorientation is affected. By means of radiation-less energy transfer, it was shown that the molecules place themselves close to the hydrophobic-hydrophilic interface inside the GM1 micelles. As a consequence they are exposed to a densely packed environment, which inhibits the free tumbling of the molecule. This restricted tumbling could be measured by means of time-resolved depolarization experiments. The release of drug-like fluorescent molecules is investigated from a lipid mixture, which upon equilibrium with water forms a mixture of inverted hexagonal and cubic phases. The lipid matrix displayed an extended release over the course of weeks, in vitro, for molecules having a large variation in hydrophobicity.

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Sutton, Damon Michael. "PH SENSITIVE RNA AND DRUG DELIVERY SYSTEMS". Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1179847644.

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Zeng, Yi. "Stable Polymer Micelle Systems as Anti-cancer Drug Delivery Carriers". Diss., CLICK HERE for online access, 2005. http://contentdm.lib.byu.edu/ETD/image/etd841.pdf.

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Hans, Meredith L. Lowman Anthony M. "Synthesis, characterization, and application of biodegradable polymeric prodrug micelles for long-term drug delivery /". Philadelphia, Pa. : Drexel University, 2006. http://dspace.library.drexel.edu/handle/1860/741.

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SCIALABBA, Cinzia. "Nanosistemi polimerici per la veicolazione di farmaci antitumorali o attivi sul sistema nervoso centrale". Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/90804.

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Ponta, Andrei G. "POLYMER MICELLES FOR TUNABLE DRUG RELEASE AND ENHANCED ANTITUMOR EFFICACY". UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/26.

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Cancer remains a leading cause of death in the United States. The most common treatment options include chemotherapy, but poor solubility, adverse side effects and differential drug sensitivity hamper clinical applications. Current chemotherapy generally aims to deliver drugs at the limit of toxicity, assuming that higher dosage increases efficacy, with little attention paid to potential benefits of tunable release. Growing evidence suggests that releasing drugs at a constant rate will be as effective as a single bolus dose. To test this hypothesis, it is critical to develop drug delivery systems that fine-tune drug release and elucidate the impact of tunable drug release rates on chemotherapeutic efficacy. Block copolymer micelles, spherical nanoassemblies with a core-shell structure, are widely used in recent research. Micelles for this study were engineered to release a model drug (doxorubicin: DOX) at differential rates under acidic conditions, corresponding to tumor tissue (pH < 7). Three specific aims were pursued: to develop drug carriers capable of tuning drug release rates; to determine activity of developed carriers in vitro; and to elucidate effects of tunable drug release rates in vivo. Block copolymers with covalently linked DOX were synthesized and self-associated, forming micelles. Drug binding linkers (glycine, aminobenzoate, or hydrazide) were used to tune release of DOX. Micelles were characterized to determine physicochemical properties such as particle size, drug entrapment yields, and drug release parameters. Characterization revealed that drug release profiles were modulated by interchanging drug binding linkers. Micelles were evaluated in vitro to elucidate the effect of tunable drug release. Micelles delivered drugs at a slower, prolonged rate compared to free DOX. Cytotoxicity and cellular internalization analysis revealed that by slowing release rates, micelles kill cells more efficiently. Biodistribution studies showed that micelles decrease DOX accumulation in peripheral tissue while increasing the maximum tolerated dose. Antitumor activity studies verified that micelles with slower release rates better suppressed tumor growth. This further confirms that release rates play a key role in chemotherapeutic efficacy. Therefore, this thesis provides better insights into the effects of tunable drug release in tumors, leading the way for improved chemotherapy treatments in the future.

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Teng, Yue. "Solubilization and release studies of small molecules in polymeric micelles /". Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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Raj, April. "Mechanistic studies to evaluate the targeting specificity of novel RGD Micelles to the αVβ3 integrin receptor". Scholarly Commons, 2012. https://scholarlycommons.pacific.edu/uop_etds/830.

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Current chemotherapeutics pose many di sadvantages due to their lack of specificity and low therapeutic index. To overcome these challenges, research has focused its attention on the development of nano-based delivery systems that can penetrate the leaky vasculature of tumor endothelium, use site-directed ligands that can bind with high affinity and specific ity to tumor cells, physically entrap poorly soluble drugs, and deliver these cytotoxic agents directly to the tumor site. One approach to nanosystem drug delivery is with the use of peptide amphiphiles (PAs) that are conjugated with the Arginine-Glycine-Aspartic Acid (RGD) motif to actively target a αVβ3 integrin receptors on cancer cells or tumor endothelium. The current work is focused on mechanistic studies to evaluate the uptake of novel RGD amphiphi les with varying alkyl chain lengths (palmitic acid : Cl 6 and stearic acid: C 18) and hydrophilic linkers, 8-amino- 3,6-dioxaoctonoic acid (ADA) or glucose, as micellar delivery systems of hydrophobic anticancer agents. PAs were confirmed for their self-assembling properties and further evaluated for their RGD-mediated binding specificity to purified αVβ3 integrin through a competitive binding fluorescence polarization assay (with novel RGD micelles displacing an integrin-bound fluorescent RGD probe by as much as 63.03%). Ultimately, these nanocarriers were assessed for their ability to deliver phys ically entrapped fluorescein isoth iocyanate (FITC) to A2058 cells overexpressing αVβ3 integrin receptors. Results from confocal microscopy indicate that uptake of RGD micelles was driven by an energy-dependent mechanism, as statistically significant levels of FITC internalization was seen at 37°C versus 4°C (p-value<0.05 for all treatment groups); moreover, intracellular fluorescence was notably higher (as much as 4-fold) when delivered through novel RGD conjugates as opposed to its free form. Regardless of chain length and the number of hydrophilic linkers, all RGD PAs showed promising results as micellar carriers that can effectively deliver their payload to the target tumor site via receptor mediated endocytosis.

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Staples, Bryant J. "Pharmacokinetics of Ultrasonically-Released, Micelle-Encapsulated Doxorubicin in the Rat Model and its Effect on Tumor Growth". Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1844.pdf.

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Libros sobre el tema "Drug delivery micellar systems"

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Ranade, Vasant V. Drug delivery systems. 3^a ed. Boca Raton: CRC Press, 2011.

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Jain, Kewal K., ed. Drug Delivery Systems. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-210-6.

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Jain, Kewal K., ed. Drug Delivery Systems. New York, NY: Springer New York, 2020. http://dx.doi.org/10.1007/978-1-4939-9798-5.

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Coghlan, Andy. Drug delivery systems. Letchworth: Society of Chemical Industry, 1985.

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K, Jain K., ed. Drug delivery systems. Totowa, NJ: Humana, 2008.

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Ranade, Vasant V. Drug delivery systems. Boca Raton, Fla: CRC Press, 1996.

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A, Hollinger Mannfred, ed. Drug delivery systems. 2^a ed. Boca Raton: CRC Press, 2004.

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(Firm), Business Technology Research, ed. Drug delivery systems. Wellesley Hills, MA: Business Technology Research, 1988.

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Popescu, Maria A. Drug delivery. Hauppauge, N.Y: Nova Science Publishers, 2011.

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Drug delivery: Engineering principles for drug delivery. New York: Oxford University Press, 2001.

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Capítulos de libros sobre el tema "Drug delivery micellar systems"

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Nishiyama, Nobuhiro, Horacio Cabral y Kazunori Kataoka. "Micellar Structures as Drug Delivery Systems". En Drug Delivery in Oncology, 1051–69. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634057.ch32.

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Kumar, Pradeep. "Targeted Micellar Systems for Pulmonary Disease Intervention". En Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases, 359–73. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-4392-7_17.

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Kumari, Smriti y Kamla Pathak. "Biopolymeric Micelles". En Advanced Biopolymeric Systems for Drug Delivery, 291–315. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-46923-8_11.

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Guliy, Olga I., Alexander S. Fomin, Elena G. Zhnichkova, Sergey V. Kozlov, Sergey A. Staroverov y Lev A. Dykman. "Polymeric Micelles for Targeted Drug Delivery Systems". En Nanotechnology in the Life Sciences, 521–59. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-12658-1_18.

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Apolinário, Alexsandra C. y Luciana B. Lopes. "Polymeric Micelles in Topical and Transdermal Delivery". En Topical and Transdermal Drug Delivery Systems, 131–47. New York: Apple Academic Press, 2022. http://dx.doi.org/10.1201/9781003284017-6.

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Zhao, Jun y Chun Li. "POLYMERIC MICELLES AS IMAGING AGENTS AND DRUG DELIVERY SYSTEMS". En Drug Delivery Applications of Noninvasive Imaging, 268–95. Hoboken, NJ: John Wiley & Sons, Inc, 2013. http://dx.doi.org/10.1002/9781118356845.ch12.

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Chen, Huabing, Zhishen Ge y Kazunori Kataoka. "Polymeric Micelles for Cancer-Targeted Drug Delivery". En Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery, 85–108. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527672752.ch4.

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Robertson, James D., Nisa Patikarnmonthon, Adrian S. Joseph y Giuseppe Battaglia. "Block Copolymer Micelles and Vesicles for Drug Delivery". En Engineering Polymer Systems for Improved Drug Delivery, 163–88. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118747896.ch6.

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Nishiyama, Nobuhiro. "Polymeric Micelles". En Cancer Drug Delivery Systems Based on the Tumor Microenvironment, 177–86. Tokyo: Springer Japan, 2019. http://dx.doi.org/10.1007/978-4-431-56880-3_8.

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Takeoka, Yukikazu, Takashi Aoki, Kohei Sanui, Naoya Ogata, Teruo Okano, Yasuhisa Sakurai y Masayoshi Watanabe. "Drug Releasing Mechanism from Redox Active Micelles". En Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems, 371–72. Tokyo: Springer Japan, 1996. http://dx.doi.org/10.1007/978-4-431-65883-2_121.

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Actas de conferencias sobre el tema "Drug delivery micellar systems"

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Amato, Alyssa y Clifford E. Larrabee. "Comparison of Micellar and Vesicle-Based Drug Delivery Systems". En The 3rd World Congress on New Technologies. Avestia Publishing, 2017. http://dx.doi.org/10.11159/icnfa17.127.

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Chong, Kyuha, Kyungsun Choi, EunSoo Kim, Eun Chun Han, Jungsul Lee, Junghwa Cha, Taeyun Ku, Jonghee Yoon, Ji Ho Park y Chulhee Choi. "Coloring brain tumor with multi-potent micellar nanoscale drug delivery system". En SPIE Nanosystems in Engineering + Medicine, editado por Sang H. Choi, Jin-Ho Choy, Uhn Lee y Vijay K. Varadan. SPIE, 2012. http://dx.doi.org/10.1117/12.946103.

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Joly-Pottuz, L., J. M. Martin, F. Dassenoy, C. Schuffenhauer, R. Tenne y N. Fleischer. "Inorganic Fullerene-Like Nanoparticles as New Lubricant Additives: A Drug Delivery Mechanism". En World Tribology Congress III. ASMEDC, 2005. http://dx.doi.org/10.1115/wtc2005-63221.

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When dispersed in a synthetic polyalphaolefin (PAO) base oil, inorganic fullerene-like (IF-MS2) nanoparticles of metal dichalcogenides (IF-MoS2, IF-WS2, IF-NbS2) lead to a significant reduction of both friction and wear under boundary lubrication. The effect of the contact pressure on the tribological properties of IF nanoparticles is particularly interesting. Results show that the higher is the pressure, the lower is the friction coefficient. The effect of the concentration shows that, even used at a low concentration (0.1%wt), IF-MS2 is able to decrease friction (0.05) compared to base oil only (0.08). A steady state friction coefficient of 0.04 was reached with IF-WS2 at 1%wt in PAO. Friction-induced transformation of the IF-MS2 nanoparticles into H-MS2 single sheets was evidenced by High Resolution Transmission Electron Microscopy (HRTEM). Some of these superimposed sheets are found in incommensurate positions, thus possibly explaining the very low friction coefficient of 0.04 obtained with IF-WS2. In-situ Raman spectroscopy was performed during a friction test to follow this structural modification. The lubrication mechanism of IF-MS2 is very similar to a “drug delivery system”. A very low concentration of additives is sufficient and the activation is obtained by the opening of the nested structure, like in certain micellar structures. Furthermore, no chemical reaction is required to obtain interesting properties. Thus, fullerene-like nanoparticles are active at the very beginning of the test and even at ambient and low temperature.

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Rana, Meenakshi y Papia Chowdhury. "Micellar systems: Novel family for drug carriers". En DAE SOLID STATE PHYSICS SYMPOSIUM 2015. Author(s), 2016. http://dx.doi.org/10.1063/1.4947737.

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HAMANAKA, YOHEI, KOHSUKE GONDA, KOUICHI SHIRAISHI, MASAYUKI YOKOYAMA, MOTOHIRO TAKEDA y NORIAKI OHUCHI. "IN VIVO REAL-TIME TRACKING OF POLYMERIC MICELLES FOR DRUG DELIVERY SYSTEM VISUALIZATION". En Proceedings of the Tohoku University Global Centre of Excellence Programme. IMPERIAL COLLEGE PRESS, 2012. http://dx.doi.org/10.1142/9781848169067_0070.

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Blanco, Elvin, Takafumi Sangai, Funda Meric-Bernstam y Mauro Ferrari. "Chemotherapeutic Synergy Enhancement Through Micellar Nanotherapeutics". En ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13263.

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Resumen

Current chemotherapeutic regimens involve the administration of a combination of agents with hopes of gaining synergistic cell-killing effects observed in vitro. However, drug synergy is rarely realized clinically given the different pharmacokinetic profiles of the drugs. Recent findings show that a combination of rapamycin and paclitaxel proves highly effective at hindering growth of tumors wherein the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. Our objective was to fabricate a micellar nanotherapeutic platform capable of delivering a multitude of agents shown to synergistically affect a specific pathway (PI3K/Akt/mTOR) in breast cancer. We hypothesized that this concomitant delivery strategy will result in increased antitumor efficacy, given the site-specific and controlled delivery of the two agents. Herein, we demonstrate the successful fabrication of a nanotherepeutic strategy for the treatment of breast tumors with aberrant PI3K/Akt/mTOR pathways. Resulting polymer micelles were small in size (∼30 nm) and showed high levels of drug incorporation efficiency of both rapamycin and paclitaxel. Current studies involve the examination of release kinetics and antitumor efficacy in in vitro and in vivo models.

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George, Ashline y Jerin Cyriac. "Nano particle based drug delivery systems". En 2017 Third International Conference on Advances in Electrical, Electronics, Information, Communication and Bio-Informatics (AEEICB). IEEE, 2017. http://dx.doi.org/10.1109/aeeicb.2017.7972386.

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Chen, Michael. "Nanotechnologies for Advanced Drug Delivery Systems". En The 5th World Congress on New Technologies. Avestia Publishing, 2019. http://dx.doi.org/10.11159/icbb19.02.

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Bellazzi, R. "Predictive fuzzy controllers for drug delivery". En Second International Conference on `Intelligent Systems Engineering'. IEE, 1994. http://dx.doi.org/10.1049/cp:19940635.

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Breland, Matthew, Badal Patel y Hassan Bajwa. "Engineered nanoparticles for targeted drug delivery". En 2012 IEEE Long Island Systems, Applications and Technology Conference (LISAT). IEEE, 2012. http://dx.doi.org/10.1109/lisat.2012.6223198.

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Informes sobre el tema "Drug delivery micellar systems"

1

Zarabi, Bahar y Hamid Ghandehari. Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors. Fort Belvoir, VA: Defense Technical Information Center, julio de 2005. http://dx.doi.org/10.21236/ada439254.

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Popova, Teodora, Borislav Tzankov, Christina Voycheva, Krassimira Yoncheva y Nikolai Lambov. Development of Advanced Drug Delivery Systems with Bicalutamide Based on Mesoporous Silica Particles. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, diciembre de 2019. http://dx.doi.org/10.7546/crabs.2019.12.08.

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Zarabi, Bahar y Hamid Ghandehari. Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors. Fort Belvoir, VA: Defense Technical Information Center, julio de 2006. http://dx.doi.org/10.21236/ada469974.

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Zarabi, Bahar. Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors. Fort Belvoir, VA: Defense Technical Information Center, diciembre de 2007. http://dx.doi.org/10.21236/ada480781.

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