Bibliografías temáticas / DPEP

Literatura académica sobre el tema "DPEP"

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Publicado: 18 de mayo de 2024

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Artículos de revistas sobre el tema "DPEP"

1

Clezy, PS, CJR Fookes, JK Prashar y A. Salek. "The Chemistry of Pyrrolic Compounds. LXVII. A New Demethyl Analog of DPEP (Deoxophylloerythroetioporphyrin)". Australian Journal of Chemistry 45, n.º 4 (1992): 703. http://dx.doi.org/10.1071/ch9920703.

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A new demethyl analogue of DPEP, present as a nickel(II) complex in the Julia Creek oil shale deposit of North Queensland, has been shown by ring synthesis to lack a methyl group in ring A. This is now the third demethyl analogue of DPEP to be identified.
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2

Zhu, Shuya, Yinxiao Zhang, Jingyi Wang, Chi Zhang y Xinqi Liu. "Investigating Differential Expressed Genes of Limosilactobacillus reuteri LR08 Regulated by Soybean Protein and Peptides". Foods 11, n.º 9 (26 de abril de 2022): 1251. http://dx.doi.org/10.3390/foods11091251.

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Soybean protein and peptides have the potential to promote the growth of Lactobacillus, but the mechanisms involved are not well understood. The purpose of this study is to investigate differentially expressed genes (DEGs) of Limosilactobacillus reuteri (L. reuteri) LR08 responding to soybean protein and peptides using transcriptome. The results showed that both digested protein (dpro) and digested peptides (dpep) could enhance a purine biosynthesis pathway which could provide more nucleic acid and ATP for bacteria growth. Moreover, dpep could be used instead of dpro to promote the ABC transporters, especially the genes involved in the transportation of various amino acids. Interestingly, dpro and dpep played opposite roles in modulating DEGs from the acc and fab gene families which participate in fatty acid biosynthesis. These not only provide a new direction for developing nitrogen-sourced prebiotics in the food industry but could also help us to understand the fundamental mechanism of the effects of dpro and dpep on their growth and metabolisms and provides relevant evidence for further investigation.
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3

Zhou, Qing, Xiotian Sun, Nicolas Pasquier, Parvaneh Jefferson, Trang T. T. Nguyen, Markus D. Siegelin, James M. Angelastro y Lloyd A. Greene. "Cell-Penetrating CEBPB and CEBPD Leucine Zipper Decoys as Broadly Acting Anti-Cancer Agents". Cancers 13, n.º 10 (20 de mayo de 2021): 2504. http://dx.doi.org/10.3390/cancers13102504.

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Transcription factors are key players underlying cancer formation, growth, survival, metastasis and treatment resistance, yet few drugs exist to directly target them. Here, we characterized the in vitro and in vivo anti-cancer efficacy of novel synthetic cell-penetrating peptides (Bpep and Dpep) designed to interfere with the formation of active leucine-zipper-based dimers by CEBPB and CEBPD, transcription factors implicated in multiple malignancies. Both peptides similarly promoted apoptosis of multiple tumor lines of varying origins, without such effects on non-transformed cells. Combined with other treatments (radiation, Taxol, chloroquine, doxorubicin), the peptides acted additively to synergistically and were fully active on Taxol-resistant cells. The peptides suppressed expression of known direct CEBPB/CEBPD targets IL6, IL8 and asparagine synthetase (ASNS), supporting their inhibition of transcriptional activation. Mechanisms by which the peptides trigger apoptosis included depletion of pro-survival survivin and a required elevation of pro-apoptotic BMF. Bpep and Dpep significantly slowed tumor growth in mouse models without evident side effects. Dpep significantly prolonged survival in xenograft models. These findings indicate the efficacy and potential of Bpep and Dpep as novel agents to treat a variety of cancers as mono- or combination therapies.
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4

Kashiyama, Y., N. O. Ogawa, M. Shiro, R. Tada, H. Kitazato y N. Ohkouchi. "Reconstruction of the biogeochemistry and ecology of photoautotrophs based on the nitrogen and carbon isotopic compositions of vanadyl porphyrins from Miocene siliceous sediments". Biogeosciences Discussions 5, n.º 1 (30 de enero de 2008): 361–409. http://dx.doi.org/10.5194/bgd-5-361-2008.

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Abstract. We determined both the nitrogen and carbon isotopic compositions of various vanadyl alkylporphyrins isolated from siliceous marine sediments of the Onnagawa Formation (middle Miocene, northeastern Japan) to investigate the biogeochemistry and ecology of photoautotrophs living in the paleo-ocean. The distinctive isotopic signals support the interpretations of previous works that the origin of 17-nor-deoxophylloerythroetioporphyrin (DPEP) is chlorophylls c, whereas 8-nor-DPEP may have originated from chlorophylls a2 or b2 or bacteriochlorophyll a. Although DPEP and cycloheptanoDPEP are presumably derived from common precursory pigments, their isotopic compositions differed in the present study, suggesting that the latter represents a specific population within the photoautotrophic community. Based on the δ 15N values of DPEP (−6.9 to −3.6‰ n=7), the average δ15N value for the entire photoautotrophic community is estimated to be −2 to +1‰, considering the empirical isotopic relationships that the tetrapyrrole nuclei of chloropigments are depleted in 15N by ~4.8‰ and enriched in ;13C by ~1.8‰ relative to the whole cells. This finding suggests that nitrogen utilized in the primary production was supplied mainly through N2-fixation by diazotrophic cyanobacteria. Based on the δ13C values of DPEP (–17.9 to −15.6‰ n=7), we estimated isotopic fractionation associated with photosynthetic carbon fixation to be 8–14‰. This range suggests the importance of β-carboxylation and/or active transport of the carbon substrate, indicating in turn the substantial contribution of diazotrophic cyanobacteria to primary production. Based on the δ15N values of 17-nor-DPEP (−7.4 to −2.4‰ n=7), the δ15N range of chlorophylls c-producing algae was estimated to be −3 to +3‰. This relative depletion in ;15N suggests that these algae mainly utilized nitrogen regenerated from diazotrophic cyanobacteria. Given that diatoms are likely to have constituted the chlorophylls c-producing algae within the biogenic-silica-rich Onnagawa Formation, cyanobacteria-hosting diatoms may have been important contributors to primary production.
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5

Kashiyama, Y., N. O. Ogawa, M. Shiro, R. Tada, H. Kitazato y N. Ohkouchi. "Reconstruction of the biogeochemistry and ecology of photoautotrophs based on the nitrogen and carbon isotopic compositions of vanadyl porphyrins from Miocene siliceous sediments". Biogeosciences 5, n.º 3 (15 de mayo de 2008): 797–816. http://dx.doi.org/10.5194/bg-5-797-2008.

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Abstract. We determined both the nitrogen and carbon isotopic compositions of various vanadyl alkylporphyrins isolated from siliceous marine sediments of the Onnagawa Formation (middle Miocene, northeastern Japan) to investigate the biogeochemistry and ecology of photoautotrophs living in the paleo-ocean. The distinctive isotopic signals support the interpretations of previous works that the origin of 17-nor-deoxophylloerythroetioporphyrin (DPEP) is chlorophylls-c1-3, whereas 8-nor-DPEP may have originated from chlorophylls-a2 or b2 or bacteriochlorophyll-a. Although DPEP and cycloheptanoDPEP are presumably derived from common precursory pigments, their isotopic compositions differed in the present study, suggesting that the latter represents a specific population within the photoautotrophic community. The average δ15N value for the entire photoautotrophic community is estimated to be –2 to +1‰ from the δ15N values of DPEP (–6.9 to –3.6‰; n=7), considering that the empirical isotopic relationships that the tetrapyrrole nuclei of chloropigments are depleted in 15N by ~4.8‰ and enriched in 13C by ~1.8‰ relative to the whole cells. This finding suggests that nitrogen utilized in the primary production was supplied mainly through N2-fixation by diazotrophic cyanobacteria. Based on the δ13C values of DPEP (–17.9 to –15.6‰; n=7), we estimated isotopic fractionation associated with photosynthetic carbon fixation to be 8–14‰. This range suggests the importance of β-carboxylation and/or active transport of the carbon substrate, indicating in turn the substantial contribution of diazotrophic cyanobacteria to primary production. Based on the δ15N values of 17-nor-DPEP (–7.4 to –2.4‰ n=7), the δ15N range of chlorophylls-c-producing algae was estimated to be –3 to +3‰. This relative depletion in sup>15N suggests that these algae mainly utilized nitrogen regenerated from diazotrophic cyanobacteria. Given that diatoms are likely to have constituted the chlorophylls-c-producing algae within the biogenic-silica-rich Onnagawa Formation, cyanobacteria-hosting diatoms may have been important contributors to primary production.
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6

Bong, ICC, PS Clezy, CJR Fookes, JK Prashar y A. Salek. "The Chemistry of Pyrrolic Compounds. LXVIII. 13'- and 15'-Methyl Analogs of Deoxophylloerythroetioporphyrin (dpep)". Australian Journal of Chemistry 46, n.º 8 (1993): 1193. http://dx.doi.org/10.1071/ch9931193.

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A new synthesis of the 13′-methyl (1a) analogue of dpep is described commencing with the methylation of phylloerythroetioporphyrin (1d) with subsequent reduction of the derived tertiary alcohol. The availability of this synthetic material has allowed the presence of this petroporphyrin as its nickel complex to be confirmed in the Julia Creek oil shales. The presence of an isomer of this petroporphyrin has been noted in the same deposit, and the structure of this novel fossil porphyrin has been confirmed as the 15′-methyl analogue (1b) of dpep by a synthesis commencing from the 15′-oxoporphyrin (1e). In addition, the 15′- and 13′-methyl analogues of dpep have been synthesized by cylization of appropriately substituted propenyl- and isopropenyl-porphyrins respectively. The origin of these two petroporphyrins is discussed.
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Clezy, PS, AH Mirza y JK Prashar. "The Chemistry of Pyrrolic Compounds. LXV. Intramolecular Cyclization of Porphyrins With Acetic Acid Side Chains: Hydroxy Derivatives of Deoxophylloerythroaetioporphyrin (DPEP)". Australian Journal of Chemistry 43, n.º 5 (1990): 857. http://dx.doi.org/10.1071/ch9900857.

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The intramolecular cyclization of porphyrins substituted with an acetic acid side chain has been studied under a range of conditions but the yield of product bearing a fused five- membered ketonic ring system was disappointingly low. Deoxophylloerythroaetioporphyrin (DPEP) derivatives with hydroxy groups at either C 13′ or C 15′ have been prepared by reduction of the corresponding ketones. 1H n.m.r . data for the latter alcohol matches well that reported for a porphyrin obtained from Marl Slate and which is probably derived from DPEP, by oxidation, during the extraction process.
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8

Premovic, Pavle, Ivana Tonsa, Dragan Djordjevic y Miroslav Premovic. "The kerogen vanadyl porphyrins: Incorporation during catagenesis". Journal of the Serbian Chemical Society 64, n.º 10 (1999): 589–98. http://dx.doi.org/10.2298/jsc9910589p.

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Natural vanadyl (VO 2+)-deoxophylloerythroetioporphyrins (DPEP) have been shown to be capable of reacting and quantitatively incorporating into immature kerogen model materials (torbanite, lignites, subbituminous coal and immature lacustrine kerogen) at 200?C for 72 h in the absence/presence of air. Electron spin resonance was used to monitor the incorporation of VO 2+-DPEP into the kerogen models. The products of the incorporation resemble natural kerogen enriched withVO 2+ . The simulation experiments described in this paper clearly show that the kerogen VO 2+-P may originate from VO 2+-DPEPincorporation into the kerogen macromolecular structures during catagenesis.
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9

Zhou, Qing y Lloyd A. Greene. "Dpep Inhibits Cancer Cell Growth and Survival via Shared and Context-Dependent Transcriptome Perturbations". Cancers 15, n.º 22 (7 de noviembre de 2023): 5318. http://dx.doi.org/10.3390/cancers15225318.

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Dpep is a cell-penetrating peptide targeting transcription factors ATF5, CEBPB, and CEBPD, and that selectively promotes the apoptotic death of multiple tumor cell types in vitro and in vivo. As such, it is a potential therapeutic. To better understand its mechanism of action, we used PLATE-seq to compare the transcriptomes of six cancer cell lines of diverse origins before and after Dpep exposure. This revealed a context-dependent pattern of regulated genes that was unique to each line, but that exhibited a number of elements that were shared with other lines. This included the upregulation of pro-apoptotic genes and tumor suppressors as well as the enrichment of genes associated with responses to hypoxia and interferons. Downregulated transcripts included oncogenes and dependency genes, as well as enriched genes associated with different phases of the cell cycle and with DNA repair. In each case, such changes have the potential to lie upstream of apoptotic cell death. We also detected the regulation of unique as well as shared sets of transcription factors in each line, suggesting that Dpep may initiate a cascade of transcriptional responses that culminate in cancer cell death. Such death thus appears to reflect context-dependent, yet shared, disruption of multiple cellular pathways as well as of individual survival-relevant genes.
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Clezy, PS y A. Salek. "The Chemistry of Pyrrolic Compounds. LXXI. Synthesis of the Ring C and the Ring D Demethyl Analogues of Deoxophylloerythroetioporphyrin (dpep)". Australian Journal of Chemistry 49, n.º 3 (1996): 265. http://dx.doi.org/10.1071/ch9960265.

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Tesis sobre el tema "DPEP"

1

Deb, Prasenjit. "Administering district primary education programme(DPEP): an evolution of the district of Cooch Behar". Thesis, University of North Bengal, 2002. http://hdl.handle.net/123456789/544.

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Morton, Colin J. H. "Novel derivatives of DPP and related heterocycles". Thesis, University of St Andrews, 1999. http://hdl.handle.net/10023/15291.

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This thesis discusses the synthesis of new organic, heterocyclic materials for potential application as pigments. Chapter 1 comprises an introduction to the field of pigment and dye chemistry, discussing the rudimentary elements of colour theory, before advancing to a review of the pertinent literature regarding high performance organic pigments. In particular, the development of 1,4-diketopyrrolo[3,4-c]pyrrole (DPP) pigments is described and the central objective of synthesising alkenyl-DPPs is outlined. Chapters 2 and 3 describe synthetic efforts towards alkenyl-DPPs, employing retro Diels-Alder methodology. The reactions involving the furan-acrylonitrile adduct as the nitrile component in the standard DPP synthesis led mainly to aromatisation of the bicyclic system and the cyclopentadiene-acrylonitrile adduct failed to react altogether. The explanation for this failure has been investigated. In the course of this these studies, several DPPs incorporating a secondary alkyl substituent were prepared, not least a novel cyclohexenyl-DPP. Chapter 4 describes the use of α β-unsaturated nitriles in the standard DPP synthesis. These behaved as Michael acceptors and in the case of cinnamonitriles led to a new family of coloured materials, namely substituted 4-hydroxy-2/7- cyclopenta[c]pyrrol-1-one-5-carbonitriles. Chapter 5 describes the corresponding reaction of cinnamate esters, but in these cases bicyclic systems were not formed. The reactions are analogous to Claisen acylations and the stereochemistry of the products varied according to the substituents. Chapter 6 contains the detailed experimental work for these investigations and concludes with a portfolio of X-ray structural data.
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3

Coat, Françoise. "Elaboration et proprietes de chaines de carbone inorganique stabilisees par les groupements terminaux (c#5me#5)(dppe)fe(ii) et (c#5me#5)(dppe)fe(iii)". Rennes 1, 1995. http://www.theses.fr/1995REN10141.

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Ce memoire de these presente la synthese et la caracterisation de nouveaux complexes homobinucleaires du fer de type donneur-accepteur en serie fe(c5me5)(dppe) et fe(c5me5)(co)2 a chaine -butadiynediyle fe(c5me5)(dppe)-( -cc cc)-fe(c5me5)(co)2n+ (n = 0, 1) ainsi que celles de complexes bimetalliques symetriques du fer en serie fe(c5me5)(dppe) a ligand pontant -octatetraynediyle fe(c5me5)(dppe)2-(-cccccccc)n+ (n = 0, 1, 2). Deux nouveaux complexes cumuleniques mono- et binucleaires fe(c5me5)(dppe)(=c=c=c(ome)me)bph4 et fe(c5me5)(dppe)-(=c=c=c=ch)-fe(c5me5)(co)2bf4 ont ete prepares avec de bons rendements par activation de derives de butadiyne par un organofer. Le complexe fe(c5me5)(co)2(ccccmts), prepare a partir du complexe fe(c5me5)(co)2l, a permis d'acceder a son analogue a ligand 1,3-butadiynyle par clivage de la liaison carbone-silicium. Ce dernier reagit avec le fe(c5me5)(dppe)cl pour donner le complexe de type donneur-accepteur fe(c5me5)(dppe)-(-cccc)-fe(c5me5)(co)2 presentant une interaction metal-metal. L'oxydation chimique monoelectronique du derive bis-feii a permis d'obtenir le complexe a valence mixte feii-feiii stable, presentant un couplage electronique notable (vab = 0,11 ev). Le complexe fe(c5me5)(dppe)(cccctms), obtenu par photochimie, conduit, par desilylation, au fe(c5me5)(dppe)(cccch) avec un bon rendement. Le complexe fe(c5me5)(dppe)2-(-cccccccc), a ete synthetise par couplage oxydant et caracterise. Une forte interaction entre les centres metalliques distants de 12,6 a a ete demontree. Le complexe bis-feii est facilement oxyde par un ou deux equivalents de sel de ferricinium et les especes stables feii-feiii et feiii-feiii resultantes ont ete isolees. Les spectroscopies mossbauer, ir et electronique ont permis de mettre en evidence, dans le complexe a valence mixte fe(c5me5)(dppe)2-(-cccccccc)pf6, le transfert d'electron intramoleculaire. Le ligand pontant carbone favorise efficacement le couplage electronique, lequel, presente la plus forte valeur (vab = 0,32 ev) jamais observee entre deux metaux a travers neuf liaisons. Ce complexe constitue donc, en ce sens, un fil moleculaire. Les complexes bis-feii, bis-feiii et feii-feiii ont revele des proprietes en optique non lineaire et les valeurs de sont parmi les plus elevees.
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LE, STANG SYLVIE. "Nouveaux composes modeles pour l'electronique moleculaire en serie cp*fe(dppe)-c 2-x-c 2-fe(dppe)cp* n + (n = 0 2, x = heterocycles aromatiques)". Rennes 1, 2000. http://www.theses.fr/2000REN10038.

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Ce manuscrit decrit la synthese et l'etude de nouveaux complexes mono- et bi-nucleaires en serie cp*fe(dppe). Les sites metalliques electroactifs portent des ligands mono- et bis-ethynylheteroaromatiques a travers lesquels peut s'etablir une communication electronique et/ou magnetique. Ces nouvelles molecules de dimension nanoscopique constituent des composes modeles pour l'electronique moleculaire. La reaction de sonogashira a permis d'acceder aux trois complexes cp*fe(dppe)-cc-c 5h 4n 4 a partir du compose cp*fe(dppe)-cc-h et des trois bromopyridines correspondantes. La complexation de ces molecules avec des complexes du palladium et du platine a permis de valider le concept de fils moleculaires auto-assembles. La synthese des complexes bimetalliques cp*fe(dppe)(cc-) 2c 5h 3n (6a:2,6-c 5h 3n ; 6b:3,5-c 5h 3n) et cp*fe(dppe)(cc-) 22,5-c 4h 2s 9 est realisee en une etape a partir du compose cp*fe(dppe)cl 1 et des bis-acetylures heteroaromatiques proteges. L'etude par voltametrie cyclique de ces derives a permis de determiner la stabilite en solution des especes a valence mixte. L'oxydation a deux electrons des complexes 6 conduit aux composes biradicalaires 6 + +. L'existence d'un couplage magnetique a ete mis en evidence par l'observation de l'etat triplet en rpe. Dans le compose a valence mixte 6a +, l'azote favorise le couplage electronique alors que dans le derive 6b +, il apparait comme un isolant dans la chaine carbonee. L'oxydation en cascade du complexe 9 conduit aux composes mono- et di-oxydes. Le complexe 9 + + existe sous deux formes en equilibre : une forme bis-radicalaire fer(iii) et une forme cumulenique fer(ii). Dans le complexe 9 +, l'electron celibataire est delocalise aux echelles de temps des spectroscopies mossbauer et rpe. Le couplage electronique est fort pour un transfert electronique mettant en jeu neuf liaisons (v a b = 2515 cm - 1) et comparable a celui determine pour le complexe cp*fe(dppe) 2cc-cc-cc-ccpf 6 (v a b = 2520 cm - 1).
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5

Růžička, Tomáš. "Tržní příležitosti pro moderní perorální antibiabetika a position nového přípravku". Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-77780.

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Diabetes Mellitus is a group of diseases, prevalence and incidence of which is on the rise not only in the Czech Republic, but also worldwide. This diploma work aims to analyze market situation and opportunities for modern oral anti-diabetic drugs. This work also designs suitable positioning for new OADs of Novartis -- Galvus and Eucreas.
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Santosh, Neetha. "Expression of Cornulin, DPEP1, SOX4 and BUB3 in Oral Premalignant Lesions". The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1467329505.

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Pantazis, Periklis. "Role of endocytic trafficking during Dpp gradient formation". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2004. http://nbn-resolving.de/urn:nbn:de:swb:14-1106665288062-25959.

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Morphogens are secreted signalling molecules that are expressed in restricted groups of cells within the developing tissue. From there, they are secreted and travel throughout the target field and form concentration gradients. These concentration profiles endow receiving cells with positional information. A number of experiments in Drosophila demonstrated that the morphogen Decapentaplegic (Dpp) forms activity gradients by inducing the expression of several target genes above distinct concentration thresholds at different distances from the source. This way, Dpp contributes to developmental fates in the target field such as the Drosophila wing disc. Although the tissue distribution as well as the actual shape and size of the Dpp morphogen concentration gradient has been visualized, the cell biological mechanisms through which the morphogen forms and maintains a gradient are still a subject of debate. Two hypotheses as to the dominant mechanism of movement have been proposed that can account for Dpp spreading throughout the Drosophila wing imaginal target tissue: extracellular diffusion and planar transcytosis, i. e. endocytosis and resecretion of the ligand that is thereby transported through the cells. Here, I present data indicating that implications of a theoreticalanalysis of Dpp spreading, where Dpp transport through the target tissue is solely based on extracellular diffusion taking into account receptor binding and subsequent internalization, are inconsistent with experimental results. By performing Fluorescence Recovery After Photobleaching (FRAP) experiments, I demonstrate a key role of Dynamin-mediated endocytosis for Dpp gradient formation. In addition, I show that most of GFP-Dpp traffics through endocytic compartments at the receiving epithelial cells, probably recycled through apical recycling endosomes (ARE). Finally, a Dpp recycling assay based on subcellular photouncage of ligand is presented to address specifically the Dpp recycling event at the receiving cells.
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8

Mamza, Jil Billy. "Comparative effectiveness and safety of DPP-4 inhibitors". Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33202/.

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Approximately 3 million people throughout the UK suffer with Type 2 diabetes mellitus (T2DM), and are 32% more likely to die early. There remains a lack of evidence for the long-term effectiveness and safety of anti-diabetic drugs in preventing diabetes-related complications, making it unclear how to optimally manage diabetes. Work to date includes observational studies subject to bias, and randomised controlled trials (RCTs), which may not reflect the ‘real world’ situation. The aim of this thesis is to combine such findings via systematic reviews, meta-analyses and retrospective cohort studies to provide more water-tight evidence of the effectiveness and safety of glucose-lowering therapies (GLT) in the long term. Firstly, a systematic review of observational studies was performed, identifying and providing a simple description of the types of biases and control measures employed in retrospective cohort studies on treatment outcomes of GLTs. Secondly, retrospective cohort studies were conducted to strengthen the evidence of the clinical effectiveness of DPP-4 inhibitors, compare their durability when combined with other anti-diabetic drugs and assess their cardiovascular safety when used in patients with T2DM, using data from The Health Improvement Network (THIN) database. Linear and logistic regression, Cox proportional hazard regression models and propensity score techniques were used to analyse routine clinical data. Thirdly, a meta-analysis was conducted on RCTs investigating the risk of bone fracture following the administration of DPP-4 inhibitor, based on data from an extensive literature search. Conducting this research has led to a better understanding of how biases may have influenced retrospective cohort studies on oral anti-diabetic drugs. An algorithm was developed to illustrate strategies for addressing biases. Potential clinical factors associated with ‘response’ to DPP-4 inhibitor treatment were found to include the addition of DPP-4 inhibitor to ongoing metformin (MET), or MET plus sulphonylurea (SU) therapy. High HbA1c at the time of treatment intensification and longer duration of diabetes were associated with the lack of HbA1c target attainment. In terms of the durability of second-line glucose-lowering agents, the co-administration of thiazolidinedione with MET was associated with the most durable glycaemic response, followed by a SU and then a DPP-4 inhibitor. Compared with a SU, adding a DPP-4 inhibitor to MET was associated with an increased need for earlier treatment intensification with a third agent. The use of statins, being a female, a smoker, having longer duration of diabetes and higher HbA1c at baseline were identified to be associated with earlier dual therapy failure. In terms of cardiovascular safety, routine clinical data showed patients who intensified MET + SU dual therapy with a DPP-4 inhibitor were associated with a decreased risk of a composite of non-fatal cardiovascular outcomes and all-cause mortality compared to those who added insulin. Furthermore, the results from meta-analysis showed DPP-4 inhibitors are not associated with increased bone fracture risks in patients with T2DM. This research is valuable in informing the choices of healthcare professionals in prescribing treatments for T2DM. For the users of this treatment, it is good news that DPP-4 inhibitors are not generally associated with fracture incidence, and that findings support the use of DPP-4 inhibitors as a second line therapeutic option, especially among non-obese patients whose glucose control remains suboptimal following MET treatment. It is recommended that treatment should be characterised on an individual basis. There remains a need for robust RCTs to investigate the influence of obesity and longer treatment durations on the efficacy of co-administering DPP-4 inhibitors to patients who are unresponsive to other oral GLTs.
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Pantazis, Periklis. "Role of endocytic trafficking during Dpp gradient formation". [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11611845.

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Araújo, Aletéia Patrícia Favacho de. "DPWP - Uma nova Abordagem para o Escalonamento Dinâmico em Computação Paralela Virtual". Universidade de São Paulo, 1999. http://www.teses.usp.br/teses/disponiveis/55/55134/tde-05032018-160952/.

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A computação distribuída sobre redes de estações de trabalho tem sido adotada como uma plataforma alternativa para a execução de aplicações paralelas. Essas redes não apresentam apenas uma boa relação custo/benefício, mas também fornecem um ambiente computacional de propósito geral, o qual pode ser usado tanto por aplicações paralelas quanto por aplicações não paralelas. Nesses ambientes multiusuários ocorre uma grande variação da carga de trabalho manipulada por cada usuário trazendo sérios problemas para o desempenho global do sistema. Dentro desse contexto, este trabalho descreve detalhadamente a implementação da DPWP, um algoritmo de escalonamento cuja principal finalidade é implantar balanceamento de cargas sobre uma rede de estações de trabalho heterogênea, para aplicações paralelas com grande quantidade de processamento. Os estudos preliminares realizados sobre os testes desenvolvidos serviram, acima de tudo, para validar e avaliar o desempenho da DPWP. Os resultados obtidos demonstram que o algoritmo tem um comportamento seguro e que as aplicações paralelas executadas, tendo a DPWP como algoritmo de escalonamento, apresentaram um excelente resultado, levando a um aumento considerável em seu desempenho final.
Distributed computing on workstation networks has been considered as an alternative platform for parallel applications. These workstation networks are not only cheaper, but also provide a general-purpose computing environment that is typically shared by both parallel and non-parallel application developers and users. Such a computing environment, where the use of resources varies as applications consume and release resources, brings important scheduling problems for global performance system. Thus, this work presents the implementation of the DPWP, a process scheduling policy aiming at balancing the computing load on a network of heterogeneous workstations, for parallel computing applications, that have more processing and less communication. Preliminary studies were developed in order to validate and to evaluate the performance reached by using the DPWP. The results showed that the scheduling policy behaves stable and the parallel applications reached excellent overall performance.
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Libros sobre el tema "DPEP"

1

Rampal, Anita. Curriculum change for quality education: A study of schools in DPEP and non-DPEP districts in Kerala. [India: s.n., 2001.

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India. Dept. of Education., ed. DPEP moves on--: Towards universalising primary education. New Delhi: Dept. of Education, Ministry of Human Resource Development, 2000.

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Prasad, Shalini. Bringing girls centrestage: Strategies & interventions for girls' education in DPEP. [NOIDA]: Educational Consultants India, 2000.

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Orissa Primary Education Programme Authority. The implementation society for DPEP, SSA, NPEGEL & RSBP in Orissa. Bhubaneswar: Orissa Primary Education Programme Authority, 2004.

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Aggarwal, Yash. Trends in access and retention: A study of primary schools in DPEP districts. [New Delhi]: Educational Consultants India, 1999.

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Kerala Research Programme on Local Level Development., ed. The teaching of English in the government/aided primary schools in Kerala under DPEP. Thiruvanathapuram: Kerala Research Programme on Local Level Development, Centre for Development Studies, 2004.

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Aggarwal, Yash. Universal access and retention: Where do we stand? : DPEP 2002 elementary education report cards. [Noida]: Published by Educational Consultants India on behalf of Dept. of Elementary Education and Literacy, Ministry of Human Resource Development, Govt. of India and National Institute of Educational Planning and Administration, New Delhi, 2002.

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Aggarwal, Yash. How many pupils complete primary education in five years?: Evidence from selected DPEP districts of Tamil Nadu. New Delhi: National Institute of Educational Planning and Administration, 2000.

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Pelevin, Viktor Olegovich. DPP (NN). Moskva: ĖKSMO, 2010.

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(Nepal), Decentralized Planning for the Child Programme. Planning for the child: DPCP update. [Kathmandu: Unicef, 2001.

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Capítulos de libros sobre el tema "DPEP"

1

Gooch, Jan W. "DPP". En Encyclopedic Dictionary of Polymers, 242. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_3983.

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Acs, Zoltan J. "The Digital Platform Economy and the Entrepreneurial State: A European Dilemma". En International Studies in Entrepreneurship, 317–44. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-94273-1_17.

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AbstractThe application of big data, new algorithms, and cloud computing is creating a digital platform economy (DPE) built around platform organizations and their platform-based ecosystem. We use the DPE Index to examine Europe’s digital efficiency across countries and explain its global position by analyzing Brexit and the electric vehicle industry. We argue that the United Kingdom left the European Union because E.U. regulations were holding back the U.K.’s strong DPE and that a weak DPE is holding German back from being a leader in the electric vehicle industry. The problem for Europe’s DPE is that the entrepreneurial state is strong and the private sector is weak.
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Green, David G., Jing Liu y Hussein A. Abbass. "DPE for Network Generation". En Dual Phase Evolution, 113–41. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-8423-4_4.

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Green, David G., Jing Liu y Hussein A. Abbass. "DPE for Problem Solving". En Dual Phase Evolution, 161–84. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-8423-4_6.

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Mundici, Daniele. "Classi fulminee per DPP". En UNITEXT, 27–31. Milano: Springer Milan, 2011. http://dx.doi.org/10.1007/978-88-470-1884-6_5.

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Sandkuhl, Kurt. "Bewertung des DPE-Ansatzes". En Systemintegration im computergestützten Publizieren, 163–85. Wiesbaden: Deutscher Universitätsverlag, 1994. http://dx.doi.org/10.1007/978-3-663-09018-2_7.

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Mundici, Daniele. "Fast Classes for DPP". En UNITEXT, 27–30. Milano: Springer Milan, 2012. http://dx.doi.org/10.1007/978-88-470-2361-1_5.

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Pardasani, R. T. y P. Pardasani. "Effective magnetic moment of CpNbCl3∙dppe". En Magnetic Properties of Paramagnetic Compounds, 325. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-23675-4_297.

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Gallina, Viola, Barna Gal, Ádám Szaller, Daniel Bachlechner, Elisabeth Ilie-Zudor y Wilfried Sihn. "Reducing Remanufacturing Uncertainties with the Digital Product Passport". En Lecture Notes in Mechanical Engineering, 60–67. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-28839-5_7.

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AbstractIn contrast to the linear production model, the circular economy aims to close the loop of materials. One part of this approach is remanufacturing, which extends the lifetime of products. Various stakeholders in the supply chain are involved in remanufacturing. This makes the management and optimization of remanufacturing activities complex. The data required for optimization is often missing, which leads to uncertainties. A new European Commission initiative, the digital product passport (DPP), is believed to facilitate information exchange in the supply chain and cloud be a good solution to reduce uncertainties. The primary purpose of this paper is the quantification and evaluation of the advantages of the DPP. Based on real industrial data, a discrete event simulation model of a remanufacturing system with three production lines was developed. The authors suppose the hypothetical existence of a DPP and illustrate the benefits arising from its application.
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Green, David G., Jing Liu y Hussein A. Abbass. "DPE Networks and Evolutionary Dynamics". En Dual Phase Evolution, 143–60. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-8423-4_5.

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Actas de conferencias sobre el tema "DPEP"

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SOUTH, David. "DPHEP: From Study Group to Collaboration (The DPHEP Collaboration)". En The European Physical Society Conference on High Energy Physics. Trieste, Italy: Sissa Medialab, 2014. http://dx.doi.org/10.22323/1.180.0511.

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Roscoe, Timothy y Bryan Lyles. "Distributing processing without DPEs". En the 9th workshop. New York, New York, USA: ACM Press, 2000. http://dx.doi.org/10.1145/566726.566773.

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Shashidharan, Ashwin, Ranga Raju Vatsavai y Ross K. Meentemeyer. "FUTURES-DPE". En SIGSPATIAL '18: 26th ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3274895.3274948.

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Mohammad, Rahman, Agawani Mamdouh y Hazza Eiman. "Drilling Professional Development Program (DPDP)". En SPE Middle East Oil & Gas Show and Conference. Society of Petroleum Engineers, 2015. http://dx.doi.org/10.2118/172660-ms.

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Hirata, Yoshinori, Katsura Nishiyama, Yasuaki Asano y Tadashi Okada. "Formation of diphenylacetylene following the photodissociation of diphenylcyclopropenone in solution". En International Conference on Ultrafast Phenomena. Washington, D.C.: Optica Publishing Group, 1996. http://dx.doi.org/10.1364/up.1996.fe.33.

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Irradiating diphenylcyclopropenone (DPCP) with a UV light, diphenylacetylene (DPAC) is produced by decarbonylation reaction with a quantum yield of unity. Previously we reported that DPAC in the excited singlet states is formed immediately after the picosecond laser pulse excitation shorter than 320 nm.1 In this paper we present the results of the transient absorption measurements of DPCP in c-hexane with a higher time resolution. Transient absorption band which can be assigned to the excited state of DPCP was observed around 470 nm.
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Qian, Zhongling, Christof Brillert, Christian Burmer y Yoshiyuki Yokoyama. "Differential and Lock-in Imaging of Dynamic Photon Emission and Applications in Failure Analysis". En ISTFA 2010. ASM International, 2010. http://dx.doi.org/10.31399/asm.cp.istfa2010p0373.

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Abstract In this paper, the differential and lockin imaging techniques of Dynamic Photon Emission (DPE) were developed by using highly sensitive near-infrared InGaAs camera in time integrated mode. At first, the setup and method for differential imaging of DPE (DI-DPE) are introduced. The unique debug and pinpointing capability of fails of DI-PEM is discussed in combination with two case studies. Based on DI-DPE, the setup and method for Lockin imaging of DPE (LI-DPE) are then developed for such cases where the correlated DPE is enhanced in strong photon emission background. The correlation in LI-DPE can separate the emission spots from different power domains.
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SOUTH, David. "DPHEP: From Study Group to Collaboration". En XXI International Workshop on Deep-Inelastic Scattering and Related Subjects. Trieste, Italy: Sissa Medialab, 2013. http://dx.doi.org/10.22323/1.191.0267.

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Mahmoud, Yousef. "Toward Reconfigurable DPP Converters". En 2022 13th International Renewable Energy Congress (IREC). IEEE, 2022. http://dx.doi.org/10.1109/irec56325.2022.10001949.

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Sagers, Jason, Jonathan D. Blotter y Timothy W. Leishman. "Active Sound Transmission Control of an Experimental Double-Panel Partition Using Decoupled Analog Feedback Control". En ASME 2008 Noise Control and Acoustics Division Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/ncad2008-73018.

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This paper addresses the construction, measurement, and analysis of a double-panel active partition (DPAP) and its accompanying analog feedback controllers. The DPAP was constructed by attaching an aluminum cone loudspeaker at each end of a short segment of a circular duct. Two analog feedback controllers were designed and built using the measured frequency response function of each panel. Two independent (decoupled) feedback controllers were then used to minimize the vibration amplitude of each panel in the presence of an acoustic disturbance. A normal-incidence transmission loss measurement system was used to assess the performance of the DPAP and of a single panel passive partition. Error signal attenuations show that it is both feasible and effective to simultaneously control both panels with decoupled feedback controllers, and that simultaneously controlling both panels of the DPAP has a distinct advantage over controlling a single panel. The reduction in vibration amplitude across the surface of the transmitting panel was confirmed with scanning laser vibrometer measurements. Transmission loss results were obtained for two passive and three active configurations. The average normal incidence transmission loss over the active measurement bandwidth (50–1,000 Hz) for the active double-panel was 60 dB. This is an average of 39 dB more transmission loss than a passive single panel partition.
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Andrianov, Nikolai. "Upscaling of Realistic Discrete Fracture Simulations Using Machine Learning". En SPE Reservoir Simulation Conference. SPE, 2021. http://dx.doi.org/10.2118/203962-ms.

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Abstract Upscaling of discrete fracture networks to continuum models such as the dual porosity/dual permeability (DPDP) model is an industry-standard approach in modelling of fractured reservoirs. While flow-based upscaling provides more accurate results than analytical methods, the application of flow-based upscaling is limited due to its high computational cost. In this work, we parametrize the fine-scale fracture geometries and assess the accuracy of several convolutional neural networks (CNNs) to learn the mapping between this parametrization and the DPDP model closures such as the upscaled fracture permeabilities and the matrix-fracture shape factors. We exploit certain similarities between this task and the problem of image classification and adopt several best practices from the state-of-the-art CNNs used for image classification. By running a sensitivity study, we identify several key features in the CNN structure which are crucial for achieving high accuracy of predictions for the DPDP model closures, and put forward the corresponding CNN architectures. Obtaining a suitable training dataset is challenging because i) it requires a dedicated effort to map the fracture geometries; ii) creating a conforming mesh for fine-scale simulations in presence of intersecting fractures typically leads to bad quality mesh elements; iii) fine-scale simulations are time-consuming. We alleviate some of these difficulties by pre-training a suitable CNN on a synthetic random linear fractures’ dataset and demonstrate that the upscaled parameters can be accurately predicted for a realistic fracture configuration from an outcrop data. The accuracy of the DPDP results with the predicted model closures is assessed by a comparison with the corresponding fine-scale discrete fracture-matrix (DFM) simulation of a two-phase flow in a realistic fracture geometry. The DPDP results match well the DFM reference solution, while being significantly faster than the latter.
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Informes sobre el tema "DPEP"

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Singh, Priyadarshini. Ideas, Policies and Practices: Tracing the Evolution of Elementary Education Reform in India since 1975s. Research on Improving Systems of Education (RISE), enero de 2023. http://dx.doi.org/10.35489/bsg-rise-2023/pe05.

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This study examines four key reform policies and programs of the Indian education system: DPEP (1994), SSA (2000), RTE (2010) and NEP (2020). Each of these has a rich and nuanced body of research to which our study contributes a unique tracing of the key ideas, debates, and stakeholders. This longue durée of reform will shed light on the histories of current reform options and if they will indeed meet the call of the times to address the learning crisis. We use the political settlements approach to understand the contestation of ideas and actors which finally determine the policy design and the implementation strategies. We unpack the iterative dynamics between ideas and actors to highlight why our reform design looks the way it does and what kind of spaces exist for transformative change particularly to ensure learning.
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Sobhy, Hania. Reforms for Another Planet: The Global Learning Crisis, Political Drivers and Expert Views on Egypt’s Edu 2.0. Research on Improving Systems of Education (RISE), febrero de 2023. http://dx.doi.org/10.35489/bsg-rise-2023/pe06.

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This study examines four key reform policies and programs of the Indian education system: DPEP (1994), SSA (2000), RTE (2010) and NEP (2020). Each of these has a rich and nuanced body of research to which our study contributes a unique tracing of the key ideas, debates, and stakeholders. This longue durée of reform will shed light on the histories of current reform options and if they will indeed meet the call of the times to address the learning crisis. We use the political settlements approach to understand the contestation of ideas and actors which finally determine the policy design and the implementation strategies. We unpack the iterative dynamics between ideas and actors to highlight why our reform design looks the way it does and what kind of spaces exist for transformative change particularly to ensure learning.
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Flory, John, Jennifer Cushion y Doug Blazer. Capability Based Resourcing for DPEM. Fort Belvoir, VA: Defense Technical Information Center, abril de 2007. http://dx.doi.org/10.21236/ada467819.

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Gardner, Timothy J., Isabelle M. Gerard, Carla R. Mowers, Evi Nemeth y Robert B. Schnabel. DPUP: A Distributed Processing Utilities Package. Fort Belvoir, VA: Defense Technical Information Center, julio de 1986. http://dx.doi.org/10.21236/ada456864.

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Appelbaum, Jr y Robert J. DPEM (Depot Purchased Equipment Maintenance) Indicators. Fort Belvoir, VA: Defense Technical Information Center, mayo de 1988. http://dx.doi.org/10.21236/ada198835.

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White, Charles, Jason Mazzoccoli, Frits Soepyan, John Eslick, Nathan Weiland, Danylo Oryshchyn y Mark Woods. DPE Techno-Economic Analyses. Office of Scientific and Technical Information (OSTI), mayo de 2023. http://dx.doi.org/10.2172/1987326.

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Fett, D., B. Campbell, J. Bradley, T. Lodderstedt, M. Jones y D. Waite. OAuth 2.0 Demonstrating Proof of Possession (DPoP). RFC Editor, septiembre de 2023. http://dx.doi.org/10.17487/rfc9449.

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Miller, Paul Matthew. Plasma Sciences Exposition at APS-DPP. Office of Scientific and Technical Information (OSTI), septiembre de 2017. http://dx.doi.org/10.2172/1391881.

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Smine, Georges E. y Vason P. Srini. Area Efficient Cells for LagerIV's DPP Library. Fort Belvoir, VA: Defense Technical Information Center, agosto de 1989. http://dx.doi.org/10.21236/ada632157.

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Basaglia, T. Data Preservation in High Energy Physics -- DPHEP Global Report 2022. Office of Scientific and Technical Information (OSTI), febrero de 2023. http://dx.doi.org/10.2172/1924319.

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