Tesis sobre el tema "Dorsal horn of the spinal cord"
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Baseer, Najma. "Spinal cord neuronal circuitry involving dorsal horn projection cells". Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5596/.
Texto completoLawson, Jeffrey J. "Encoding of periodic skin stimuli by spinal dorsal horn neurons". Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1654.
Texto completoTitle from document title page. Document formatted into pages; contains ix, 140 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 123-137).
Jennings, Ernest Albert. "Cutaneous afferent evoked activity in the postnatal rat spinal cord". Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369052.
Texto completoVu, Hung. "Mechanisms of rapid receptive field reorganization in rat spinal cord". Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3197/.
Texto completoAl, Ghamdi Kholoud Saad. "Populations of spinal cord dorsal horn neurons and their role in nociception". Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3425/.
Texto completoSuthamnatpong, Ornsiri. "Organisational aspects of the superficial dorsal horn of the lumbar spinal cord". Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263765.
Texto completoNagy, Gergely György. "Glutamate receptors in the spinal cord with emphasis on the dorsal horn". Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/30731/.
Texto completoHeppenstall, Paul Alexander. "Mechanisms of neurokinin₁ receptor action in the dorsal horn of the spinal cord". Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/29799.
Texto completoLaird, Jennifer Marie Ann. "Dorsal horn neurones in the sacral spinal cord of the rat : receptive field and encoding properties". Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330080.
Texto completoMaile, Rebecca Ann. "Sensory processing in the isolated in vitro rat spinal cord with particular emphasis on opioid-related peptides, excitatory and inhibitory amino acids". Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249598.
Texto completoMiyazaki, Yoshiya. "Xenon Has Greater Inhibitory Effects on Spinal Dorsal Horn Neurons than Nitrous Oxide in Spinal Cord Transected Cats". Kyoto University, 2000. http://hdl.handle.net/2433/181269.
Texto completoStewart, Anika Louise. "Which neurones in the superficial dorsal horn of the rat spinal cord mediate acute itch?" Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425704.
Texto completoLever, Isobel Jane. "The release of two neuromodulators : BDNF and substance P from the isolated spinal cord dorsal horn". Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407449.
Texto completoRottkamp, Catherine Anne-Marie. "The Role of Hox Cofactors in Vertebrate Spinal Cord Development". Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1194575822.
Texto completoAhmed, Sheikh Maie Idil. "Nociceptin and the ORLâ‚ receptor : analgesic mechanisms and interactions with dorsal horn neurones in rat spinal cord". Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423550.
Texto completoPerez, Sanchez Jimena. "Unconventional components of inhibition that contribute to the regulation of sensitization in the spinal cord dorsal horn". Doctoral thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/33255.
Texto completoThe dorsal horn of the spinal cord contains a diverse population of neurons that are responsible for the integration and transmission of pain-related information into the brain. The excitability of these neurons is largely controlled by γ-aminobutyric acid (GABA) and glycine, the two main inhibitory neurotransmitters in the central nervous system. Conventional synaptic inhibition is mediated by chloride-permeable GABAA and glycine receptors, located directly opposite to presynaptic terminals. However, a different subset of these receptors is located outside the synapse and provides further functional diversity of inhibition. The studies presented in this thesis employed a wide variety of approaches to explore two non-conventional components of inhibition in the regulation of pain-related transmission in the dorsal horn of the spinal cord. The first is the role of non-synaptic GABAergic receptors that produce tonic inhibition; the second is the regulation of intracellular chloride gradients that determine the strength of GABAergic inhibition. The results show that there is a gradient of inhibition across the dorsal horn, with weaker inhibition in superficial levels, and increasingly stronger in deeper levels. This is evidenced by a differential contribution of α5 subunit-containing GABAA receptors (α5GABAARs) to tonic inhibition across the dorsal horn of the spinal cord. Importantly, the basal activity of these receptors is not strong enough to counter sensitization of pain-related information but contributes to the recovery from these sensitized states. Enhancing the activity of α5GABAARs also does not constrain sensitization. In contrast, the activity of other tonicinhibition- producing GABAA receptors, namely those that contain δ subunits (δGABAARs), can be enhanced to decrease sensitization in the dorsal horn. On the other hand, there is a also gradient in chloride homeostasis, which affects how different neurons integrate synaptic inputs. In fact, I found that chloride homeostasis modulates the propensity and stability of synaptic plasticity. As such, higher activity of the neuronal chloride extruder (KCC2), such as that present in deeper levels of the dorsal horn, is directly linked to a stable, or constrained, long-term potentiation (LTP). Conversely, low chloride extrusion capacity in superficial levels leads to enhanced and unstable LTP in the dorsal horn. In conclusion, I uncovered a gradient of inhibition across the dorsal horn that shapes the sensitization of nociceptive information. Weak inhibition at superficial levels leads to enhanced and unconstrained synaptic plasticity, whereas stronger inhibition stabilizes plasticity at deeper levels of the dorsal horn
De, Koninck Yves. "Physiology, chemistry and immunocytochemistry of selected synaptically elicited responses in dorsal horn neurones aof the cat spinal cord". Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70211.
Texto completoLow-threshold mechanical stimulation of the skin produced two types of inhibitory postsynaptic potential (IPSP) in dorsal horn neurones. One was shown to involve $ gamma$-aminobutyric acid (GABA) acting on a GABA$ sb{ rm A}$ receptor and the other one involves adenosine acting on a P$ sb1$-purinergic receptor. The adenosine-mediated IPSP is mediated by activation of ATP-sensitive K$ sp+$ channels. Further characterization of these IPSPs revealed that the adenosine-mediated IPSP is involved in a system responding optimally to repetitive mechanical stimulation.
Stimulation of hair afferents produced EPSPs which are mediated by an excitatory amino acid. Characterization of the input from single hair afferents to single dorsal horn neurones revealed that the central excitatory response to guard-hair afferent input, but not that to down-hair afferent input is subject to a prolonged GABA$ sb{ rm A}$-mediated inhibitory mechanism.
The response to noxious cutaneous stimulation involves at least two types of EPSP in dorsal horn neurones. The fast EPSP in response to a brief stimulus is probably elicited by an excitatory amino acid, whereas sustained noxious stimulation elicits a slow, prolonged EPSP mediated by substance P acting on the NK-1 receptor.
These results demonstrate the participation of specific chemical mechanisms in the mediation of specific physiological responses in identifiable sensory pathways in the spinal cord.
Maie, I. A. S. "Nociceptin and the ORL-1 receptor : analgesic mechanisms and interactions with dorsal horn neurones in rat spinal cord". Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444486/.
Texto completoDolique, Tiphaine. "Déséquilibre excitation/inhibition dans la moelle épinière dorsale en situation de douleurs chroniques : rôle des molécules d’adhérence neuroligines". Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21820/document.
Texto completoIn chronic pain states, central sensitization is associated with a modification in the excitation/inhibition balance toward increased excitation in the spinal dorsal horn. This balance involves adhesion molecules such as the postsynaptic Neuroligins (NLs). In a first part of our thesis work, we investigated the putative regulation of these proteins in the Spinal Nerve Ligation (SNL) model of neuropathy in the rat. Our data showed an unexpected upregulation of NL2, usually associated to inhibition, whereas expression of NL1, usually associated to excitation, did not change. The in vivo expression blockade of NL2 by intrathecal injection of siRNAs, produced specific antinociceptive effects, significantly reversing the SNL-induced mechanical allodynia. Subsequent study of pre- and postsynaptic NL2 partners, demonstrated a specific co-variation with PSD95, a scaffolding protein of excitatory synapses. Moreover, a co-immunoprecipitation approach showed a significant increase of NL2/PSD95 protein interactions in SNL rats. Finally, this unusual association in neuropathic conditions, appeared to be linked to specific over-expression of NL2(-), a NL2 splice variant usually a minority in physiological conditions. Over-expression, increased association with PSD95, and unexpected pronociceptive effect of the “inhibitory” NL2 in neuropathic pain condition, suggest a functional shift of NL2 from inhibition to excitation changing the synaptic ratio toward higher overall excitation in the dorsal horn.In a second part of our work, we investigated the role of the NLs adhesion molecules in spinal sensitization associated with another type of chronic pain, namely cancer pain, using a rat model of bone cancer. The study of the expression of NLs and partners, showed a specific increase in the expression of NL1 and S-SCAM, another postsynaptic scaffolding protein at excitatory synapses. Moreover, according to the literature, this model is characterized by a strong glial activation in the spinal dorsal horn, identified especially by a massive astrogliosis. However, we showed that in the bone cancer model used, there was no variation, neither in the classical markers of astrocyte activation (GFAP, S100β), nor in microglial markers (OX-42 et Iba1). On the contrary, all these parameters did actually increase in the ipsilateral dorsal horn of SNL neuropathic rats. These results suggest that, at odd with what was previously described, bone cancer pain is not necessarily correlated with a spinal overexpression of markers of reactive glia, whereas neuropathic pain is.In conclusion, our results obtained with the cancer pain model, show that the molecules involved in the formation, specification and modulation of synapses, yield a phenotypes clearly different to the one evidenced in the model of neuropathic pain. More particularly, we show in the two models, a well distinct involvement of the NL adhesion molecules and of glia, reinforcing reports from the literature, which indicate that the two important categories of chronic pain, cancer and neuropathic, each have a peculiar signature. Moreover, our results raise the possibility that new diagnosis and/or new therapeutic possibilities may emerge from targeting NL expression
Pitcher, Mark H. "The effects of persistent peripheral inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors /". Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98770.
Texto completoWood, Malcolm S. "Characterization of opioid binding sites in spinal cord and other tissues". Thesis, Loughborough University, 1988. https://dspace.lboro.ac.uk/2134/25215.
Texto completoBen, Ayed Sara [Verfasser] y Hilmar [Akademischer Betreuer] Bading. "Ca2+ signalling and its consequences in the mouse spinal cord dorsal horn under chronic pain / Sara Ben Ayed ; Betreuer: Hilmar Bading". Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1197056777/34.
Texto completoMerighi, Adalberto. "Light and electron microscopical studies on the distribution of peptides and 'classical' neurotransmitters in dorsal root ganglion cells and in the dorsal horn of the spinal cord". Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46446.
Texto completoBailey, Andrea Lee. "A behavioural and morphological analysis of compromised primary afferent C-fibre input to the superficial dorsal horn of the rat spinal cord". Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66754.
Texto completoLa douleur neuropathique est causée par des lésions des fibres afférentes primaires. Les fibres nerveuses de type C (non-myélinisées) sont d'un intérêt particulier, étant responsables de la transmission des influx douloureux provenant de la périphérie. La population de fibres nerveuses C est hétérogène: a) la population peptidergique contient des neuropeptides comme la substance P (sP) et le peptide lié au gène de la calcitonine (CGRP); b) la population non-peptidergique a la capacité de se lier à la lectine IB4. Notre compréhension de la nature de l'information nociceptive et des mécanismes impliqués dans le traitement de celle-ci par ces fibres afférentes non-peptidergiques dans la moelle épinière restent limités. Dans cette thèse, nous avons étudié les conséquences morphologiques, neurochimiques et comportementales des lésions des fibres afférentes primaires de type C (C-PAFs) dans la corne dorsale superficielle. Cet effort fut mené de deux façons: soit par des lésions produites par constriction du nerf sciatique, soit par suppression sélective de la sous-population de C-PAFs se liant à IB4. L'observation des terminaisons des PAFs se liant à IB4 dans la couche II révélait la perte passagère du marquage d'IB4 résultant de la dégénérescence des glomérules synaptiques CIa. Des tests mesurant les temps de retrait de patte en réponse à des stimulations mécaniques, thermiques chaudes et froides appliquées à la périphérie furent effectués chez ces animaux. Spécifiquement, les seuils de retrait étaient plus faibles lors des tests de nociception thermique effectués au cours des trois semaines d'étude. La réactivité aux stimulations froides était également significativement altérée chez les animaux neuropathiques. Les seuils de retraits de patte vis-à-vis les stimulations mécaniques étaient significativement réduits chez les animaux neuropathique
Plenderleith, M. B. "The effects of neonatal capsaicin treatment on the functional properties of sensory neurones in the dorsal horn of the rat spinal cord". Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356742.
Texto completoDhanasobhon, Dhanasak. "Spinal cholinergic system and chronic pain". Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ090/document.
Texto completoAn endogenous spinal cholinergic tone modulating nociceptive (painlike) behaviors has been demonstrated in rodents and humans. One potential source of this acetylcholine is the spinal Dorsal Horn (DH) cholinergic interneurons. Our objectives were to: (1) characterize the spinal cholinergic tone establishing mechanical nociceptive thresholds and (2) to elucidate the role of DH cholinergic neurons in the modulation of sensory information of naïve and neuropathic animals. We have confirmed the presence of a cholinergic tone modulating mechanical thresholds and demonstrated that it is still present, although altered, after neuropathy. The DH cholinergic interneurons receive excitatory inputs from distant spinal segments and generally receive lower inhibitory inputs. In addition, they are indirectly connected by a subset of nociceptive primary afferents expressing TRPV1, demonstrating their involvement in nociceptive processing. In neuropathic spinal circuits, the inputs to LIII/IV neurons appears to be unaffected after injury. Better understanding the spinal cholinergic system can pave way to alternative pain therapy
Morgan, Elise. "The in vitro rat spinal cord : an investigation into the role of excitatory glutamate in nociception using electrophysiological and immunohistochemical techniques". Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313208.
Texto completoFord, Neil C. "The role of voltage-independent cation channels in shaping spinal nociceptive circuit output and pain sensitivity in developing rodents". University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1530798481340688.
Texto completoSeibt, Frederik. "Effets de la noradrénaline sur les transmissions synaptiques dans la corne dorsale de la moelle épinière de rat". Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ029/document.
Texto completoThe dorsal horn of the spinal cord (DH) is an important site of integration and modulation of somatosensory information and deep laminae of the DH play an important role in the modulation of nociceptive information in the neuronal network of the spinal cord.Our aim was to characterize the effects of NA on synaptic transmission in deep laminae of the DH.We show that NA facilitates inhibitory synaptic transmission in laminae III-IV of the DH. This phenomenon involves the activation of alpha1, alpha2, and beta adrenoceptors and requires intact interlaminar communications between laminae III-IV and V. Glial cell metabolism inhibition has the same consequences as a mechanical section between laminae IV and V. These results indicate that an interaction between glial cell and deep laminae neurons of the DH seems essential for the facilitatory effect of NA on inhibitory synaptic communications in laminae III-IV of the DH
Gerke, Michelle Barbara. "Characterisation of the expression of cell-surface carbohydrates by primary sensory neurones and their applications in the study of pain". Thesis, Queensland University of Technology, 2000.
Buscar texto completoMesnage, Bruce. "Système cholinergique et modulation de la transmission nociceptive spinale". Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ122/document.
Texto completoIn the spinal cord dorsal horn (SCDH), endogenous acetylcholine (ACh) acts as a powerful analgesia, of clinical use. Though its source and mechanisms remain unravelled, this analgesia probably lies in a plexus of cholinergic fibers (PCF) located in the SCDH and of undetermined origin. In this context, we established that the PCF mainly originates from a spinal population of cholinergic interneurons, fully characterized in this work. These are, thus, the likely substrate of the spinal cholinergic analgesia.Besides, ACh receptors (AChR) partly mediate the analgesic acute effects of morphine. In this work, we also observed that a chronically-administered AChR agonist reproduces as well the pro-algesic effects of morphine in the same conditions. Thus, ACh appears as a possible intermediary or a final effecter of the morphine pain pathways.Our data suggest that the cholinergic system could become a new putative therapeutic target in pain management and treatment
Zell, Vivien. "Impact des glucocorticoïdes circulants sur la maturation et le fonctionnement de l'inhibition spinale GABAergique". Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ097/document.
Texto completoGlucocorticoids (GC) are steroid hormones synthesized in adrenals following HPA axis activation. GC production is a response of the organism to alleviate homeostasis perturbations through different actions. One of them involves central neuronal modulation of behavior and pain perception.Primary afferents convey peripheral sensory information in the dorsal horns of the spinal cord. This information can be nociceptive and are modulated by a spinal neuronal network before being transmitted and integrated. We showed that GC are implied in the maturation and functioning of the inhibitory transmission involving GABA neurotransmitter. In the dorsal horns this inhibitory transmission is of major importance, limiting the processing of nociceptive information
Kuster, Robin. "Modulation sexe-dépendante du traitement des informations nociceptives par l'inhibition GABAergique spinale". Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ016.
Texto completoThe short-term plasticity of GABAergic synapses in the lamina II of the spinal cord is essential for processing nociceptive information. This plasticity varies depending on the type of postsynaptic neuron, whether excitatory or inhibitory. Our findings indicate a sex-specific modulation of GABAergic synaptic transmission, particularly in response to acute peripheral inflammation. These observations highlight the importance of maintaining a balance between inhibition and excitation in processing nociceptive information. They also suggest that mechanisms regulating GABAergic synaptic transmission may explain differences in mechanical and thermal sensitivity between males and females.Our work enhances understanding of the neurobiological mechanisms of nociception, considering often overlooked sex-related differences
Saeed, Abeer Wael. "Chronic neuropathic pain and spinal dorsal horn plasticity". Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110356.
Texto completoLa douleur chronique est une condition débilitante ayant de sérieuses répercussions socio-économiques. L'objectif de cette thèse était de mieux comprendre l'organisation de la corne dorsale de la moelle épinière et les changements qui s'y produisent dans les cas de douleurs chronique neuropathique suite à une lésion du système nerveux. Nos études se sont concentrées sur deux composantes importantes des circuits de la douleur: les neurones de projection et leur innervation par les afférents nociceptifs de petit diamètre. Les neurones de projection de la couche 1 de la moelle épinière sont classées selon leur morphologie en 3 types: les neurones fusiformes, multipolaires et pyramidaux. Les deux premiers répondent aux stimuli douloureux et expriment le récepteur de la substance P (NK-1r), alors que les neurones pyramidaux n'expriment ce récepteur qu'occasionellent et répondent au froid non-douloureux. Les deux populations d'afférents principales sont les fibres de petit diamètre peptidergiques, qui expriment la substance P et le "calcitonin gene-related peptide" (CGRP), et les non-peptidergiques, qui sont dépourvues de neuropeptides et qui s'associent avec la lectine IB4. Lors du premier chapitre expérimental, nous avons étudié les changement qui se produisent dans la corne dorsale de la moelle épinière dans un modèle de douleur neuropathique chronique. Nous avons démontré une expression de novo du NK-1r sur les neurones pyramidales, un changement similaire à celui se produisant dans un modèle d'arthrite chronique. Ce changement de phénotype était associé à une augmentation significative du nombre d'appositions peptidergiques faites sur cette population neuronale, qui reçoit habituellement très peu de ces entrées. Afin de vérifier si ces récepteurs sont fonctionnels et répondent aux stimuli douloureux, nous avons injecté de la capsaicine dans la patte arrière, ce qui a mené à une internalisation du récepteur, marquant l'activation de celui-ci. Le deuxième chapitre de cette thèse vérifie si un état de douleur chronique est nécéssaire pour ce changement phénotypique, utilisant une lésion non douloureuse qui cause une augmentation signnificative du NK-1r dans la corne dorsale. Dans ce modèle, une population de nocicepteurs non peptidergiques est excise par une injection dans le nerf sciatique de la toxine saporine conjuguée à la lectine IB4 (IB4-SAP). En absence de symptômes douloureux, la couche 1 de la corne dorsale des animaux lésés a subi une augmentation générale du NK-1r mais sa distribution cellulaire est restée normale, sans expression de novo sur les cellules pyramidales.Lors du troisième chapitre de cette thèse, nous avons vérifié si les neurones de projection de la couche 1 exprimant le NK-1r recevaient des entrées des fibres nociceptives non peptidergiques, comme ce sujet était controversé suite à une publication utilisant des souris transgéniques démontrant une absence de connections de la sorte. Nous avons fait une étude systématique utilisant la microscopie confocale et électronique et avons démontré que les 3 types morphologiques de cellules de projection reçoivent des entrées non peptidergiques directes.Pris ensembles, les résultats de cette thèse suggèrent qu'une condition de douleur chronique est nécessaire pour l'expression du NK-1r sur les neurones pyramidaux et l'augmentation des entrées peptidergiques faites sur celles-ci. D'autres études seront nécessaires pour clarifier l'implication des entrées non peptidergiques faites sur les neurones de projection dans la nociception normale et dans la douleur chronique.
Waters, Alexander Juergen. "Control of spinal nociception by the midbrain periaqueductal grey matter". Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310695.
Texto completoGanley, Robert. "Characterisation of distinct inhibitory interneuron populations in the spinal dorsal horn". Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/7003/.
Texto completoGormley, Ann Marie. "Transgenic approaches to studying the development of sensory and spinal cord neurons". Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244742.
Texto completoGreenspon, Charles. "Linear multi-electrode arrays for recording population data from the spinal dorsal horn". Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52849/.
Texto completoKikukawa, Soki. "Regeneration of dorsal column axons after spinal cord injury in young rats". Kyoto University, 1999. http://hdl.handle.net/2433/181700.
Texto completoKyoto University (京都大学)
0048
新制・課程博士
博士(医学)
甲第7731号
医博第2084号
新制||医||708(附属図書館)
UT51-99-G325
京都大学大学院医学研究科脳統御医科学系専攻
(主査)教授 金子 武嗣, 教授 柴崎 浩, 教授 川口 三郎
学位規則第4条第1項該当
Rydh-Rinder, Malin. "Studies on pain-related messengers and receptors in dorsal root ganglia and spinal cord /". Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4553-5/.
Texto completoOgura, Takenori. "Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells". Kyoto University, 2019. http://hdl.handle.net/2433/236613.
Texto completoTyler, Alan Wayne. "Studies on the ionic basis of primary afferent depolarization in the isolated mammalian spinal cord". Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296523.
Texto completoGlasgow, Stacey Marie. "The role of PTF1A in spinal cord development". Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=155.
Texto completoAraújo, Lucas Guilherme de. "On cholecystokinin-opioid interaction in the spinal dorsal horn following peripheral nerve injury and inflammation /". Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3560-2/.
Texto completoChen, Ying. "Study of the dorsal root reflex activity in an isolated mammalian spinal cord preparation". Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359141.
Texto completoManire, Meredith Ann. "Activating Neuron-Intrinsic Growth Pathways to Promote Spinal Cord Regeneration After Dorsal Root Injury". Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/559555.
Texto completoPh.D.
Primary sensory axons fail to regenerate into the spinal cord following dorsal root injury leading to permanent sensory deficits. Re-entry is prevented at the dorsal root entry zone (DREZ), the CNS-PNS interface. Current approaches for promoting DR regeneration across the DREZ have had some success, but sustained, long-distance regeneration, particularly of large-diameter myelinated axons, still remains a formidable challenge. Our lab has previously shown that induced expression of constitutively active B-RAF (kaBRAF) enhanced the regenerative competence of injured DRG neurons in adult mice. In this study, I investigated whether robust intraspinal regeneration can be achieved by selective expression of kaBRAF alone or in combination with deletion of the myelin-associated inhibitors or neuron-intrinsic growth suppressors (PTEN or SOCS3). To this end, I used LSL-kaBRAF: brn3a-CreERT2 transgenic mice in which kaBRAF can be induced selectively in sensory neurons. I have also bred LSL-kaBRAF: brn3a-CreERT2 mice with triple knock-out mice lacking Nogo, Mag and OMgp or mouse lines carrying floxed alleles of PTEN or SOCS3. Single, double, and triple conditional mice were subjected to cervical DR crush and AAV2-eGFP vectors were used to selectively label regenerating axons of large-diameter neurons. I compared the extent of regeneration at 3 weeks or 2 months after DR injury using conventional anatomical and behavioral analyses. I found that kaBRAF alone promoted axon regeneration across the DREZ but did not produce significant functional recovery by two months. Supplementary deletion of Nogo, MAG, and OMgp did not improve kaBRAF-induced regeneration. Deletion of PTEN or SOCS3 individually or in combination failed to promote axon regeneration across the DREZ. In marked contrast, simultaneous deletion of PTEN, but not SOCS3, dramatically enhanced kaBRAF-mediated regeneration enabling many more axons to penetrate the DREZ and grow deep into the spinal cord. This study shows that dual activation of BRAF-MEK-ERK and PI3K-Akt signaling is an effective strategy to stimulate robust intraspinal DR regeneration and may lead to recovery of sensory function after DR injury.
Temple University--Theses
Manire, Meredith A. "ACTIVATING NEURON-INTRINSIC GROWTH PATHWAYS TO PROMOTE SPINAL CORD REGENERATION AFTER DORSAL ROOT INJURY". Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/585310.
Texto completoPh.D.;
Primary sensory axons fail to regenerate into the spinal cord following dorsal root injury leading to permanent sensory deficits. Re-entry is prevented at the dorsal root entry zone (DREZ), the CNS-PNS interface. Current approaches for promoting DR regeneration across the DREZ have had some success, but sustained, long-distance regeneration, particularly of large-diameter myelinated axons, still remains a formidable challenge. Our lab has previously shown that induced expression of constitutively active B-RAF (kaBRAF) enhanced the regenerative competence of injured DRG neurons in adult mice. In this study, I investigated whether robust intraspinal regeneration can be achieved by selective expression of kaBRAF alone or in combination with deletion of the myelin-associated inhibitors or neuron-intrinsic growth suppressors (PTEN or SOCS3). To this end, I used LSL-kaBRAF: brn3a-CreERT2 transgenic mice in which kaBRAF can be induced selectively in sensory neurons. I have also bred LSL-kaBRAF: brn3a-CreERT2 mice with triple knock-out mice lacking Nogo, Mag and OMgp or mouse lines carrying floxed alleles of PTEN or SOCS3. Single, double, and triple conditional mice were subjected to cervical DR crush and AAV2-eGFP vectors were used to selectively label regenerating axons of large-diameter neurons. I compared the extent of regeneration at 3 weeks or 2 months after DR injury using conventional anatomical and behavioral analyses. I found that kaBRAF alone promoted axon regeneration across the DREZ but did not produce significant functional recovery by two months. Supplementary deletion of Nogo, MAG, and OMgp did not improve kaBRAF-induced regeneration. Deletion of PTEN or SOCS3 individually or in combination failed to promote axon regeneration across the DREZ. In marked contrast, simultaneous deletion of PTEN, but not SOCS3, dramatically enhanced kaBRAF-mediated regeneration enabling many more axons to penetrate the DREZ and grow deep into the spinal cord. This study shows that dual activation of BRAF-MEK-ERK and PI3K-Akt signaling is an effective strategy to stimulate robust intraspinal DR regeneration and may lead to recovery of sensory function after DR injury.
Temple University--Theses
Jeffrey, N. D. "Behavioural consequences of demyelination and remyelination in the dorsal funiculus of the rat spinal cord". Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605078.
Texto completoGoodman, Keiser Melanie Dawn. "Postsynaptic dorsal column spinal pathway does it play a role in cardiac pain? /". Oklahoma City : [s.n.], 2009.
Buscar texto completoBrewer, Chelsie L. "Spinal inhibitory mechanisms controlling somatosensation: maturation and neonatal injury". University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1581333223198031.
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