Bibliografías temáticas / Dissociation constant of inhibitor

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Literatura académica sobre el tema "Dissociation constant of inhibitor"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 20 de febrero de 2023

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Artículos de revistas sobre el tema "Dissociation constant of inhibitor"

1

Björk, I., E. Pol, E. Raub-Segall, M. Abrahamson, A. D. Rowan, and J. S. Mort. "Differential changes in the association and dissociation rate constants for binding of cystatins to target proteinases occurring on N-terminal truncation of the inhibitors indicate that the interaction mechanism varies with different enzymes." Biochemical Journal 299, no. 1 (April 1, 1994): 219–25. http://dx.doi.org/10.1042/bj2990219.

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The importance of the N-terminal region of human cystatin C or chicken cystatin for the kinetics of interactions of the inhibitors with four cysteine proteinases was characterized. The association rate constants for the binding of recombinant human cystatin C to papain, ficin, actinidin and recombinant rat cathepsin B were 1.1 x 10(7), 7.0 x 10(6), 2.4 x 10(6) and 1.4 x 10(6) M-1.s-1, whereas the corresponding dissociation rate constants were 1.3 x 10(-7), 9.2 x 10(-6), 4.6 x 10(-2) and 3.5 x 10(-4) s-1. N-Terminal truncation of the first ten residues of the inhibitor negligibly affected the a
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2

Hofsteenge, J., H. Taguchi, and S. R. Stone. "Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors." Biochemical Journal 237, no. 1 (July 1, 1986): 243–51. http://dx.doi.org/10.1042/bj2370243.

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Thrombomodulin decreased by 20-30% the Michaelis constant of two tripeptidyl p-nitroanilide substrates of thrombin. Thrombomodulin increased the rate of inactivation of thrombin by two peptidyl chloromethane inhibitors by a similar amount. This effect appeared to be due to a decrease in the dissociation constants of the inhibitors. An improved method for the separation of fibrinopeptides A and B by h.p.l.c. was developed, and this method was used to study the effect of thrombomodulin on the thrombin-catalysed cleavage of fibrinogen. In this reaction, thrombomodulin was a competitive inhibitor
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3

Boudier, C., and J. G. Bieth. "Oxidized mucus proteinase inhibitor: a fairly potent neutrophil elastase inhibitor." Biochemical Journal 303, no. 1 (October 1, 1994): 61–68. http://dx.doi.org/10.1042/bj3030061.

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N-chlorosuccinimide oxidizes one of the methionine residues of mucus proteinase inhibitor with a second-order rate constant of 1.5 M-1.s-1. Cyanogen bromide cleavage and NH2-terminal sequencing show that the modified residue is methionine-73, the P′1 component of the inhibitor's active centre. Oxidation of the inhibitor decreases its neutrophil elastase inhibitory capacity but does not fully abolish it. The kinetic parameters describing the elastase-oxidized inhibitor interaction are: association rate constant kass. = 2.6 x 10(5) M-1.s-1, dissociation rate constant kdiss. = 2.9 x 10(-3) s-1 an
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4

Brown, Nicholas G., Dar-Chone Chow, and Timothy Palzkill. "BLIP-II Is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2)." Antimicrobial Agents and Chemotherapy 57, no. 7 (April 15, 2013): 3398–401. http://dx.doi.org/10.1128/aac.00215-13.

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ABSTRACTβ-Lactamase inhibitory protein II (BLIP-II) is a potent inhibitor of class A β-lactamases. KPC-2 is a class A β-lactamase that is capable of hydrolyzing carbapenems and has become a widespread source of resistance to these drugs for Gram-negative bacteria. Determination of association and dissociation rate constants for binding between BLIP-II and KPC-2 reveals a very tight interaction with a calculated (koff/kon) equilibrium dissociation constant of 76 fM (76 × 10−15M).
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LOHSE, Anders, Tore HARDLEI, Astrid JENSEN, Igor W. PLESNER та Mikael BOLS. "Investigation of the slow inhibition of almond β-glucosidase and yeast isomaltase by 1-azasugar inhibitors: evidence for the ‘direct binding’ model". Biochemical Journal 349, № 1 (26 червня 2000): 211–15. http://dx.doi.org/10.1042/bj3490211.

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(-)-1-Azafagomine [(3R,4R,5R)-4,5-dihydroxy-3-hydroxymethylhexahydropyridazine; inhibitor 1] is a potent glycosidase inhibitor designed to mimic the transition state of a substrate undergoing glycoside cleavage. The inhibition of glycosidases by inhbitor 1 and analogues has been found to be a relatively slow process. This ‘slow inhibition’ process was investigated in the inhibition of almond β-glucosidase and yeast isomaltase by inhibitor 1 and analogues. Progress-curve experiments established that the time-dependent inhibition of both enzymes by inhibitor 1 was a consequence of relatively slo
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6

Lindahl, P., E. Raub-Segall, S. T. Olson, and I. Björk. "Papain labelled with fluorescent thiol-specific reagents as a probe for characterization of interactions between cysteine proteinases and their protein inhibitors by competitive titrations." Biochemical Journal 276, no. 2 (June 1, 1991): 387–94. http://dx.doi.org/10.1042/bj2760387.

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Papain was labelled by attachment of the fluorescent groups 2-(4′-acetamidoanilino)naphthalene-6-sulphonic acid (AANS) or N-(acetylaminoethyl)-8-naphthylamine-1-sulphonic acid (AEDANS) to the active-site cysteine residue, with the aim of using the labelled papains as probes in competitive titrations of unlabelled cysteine proteinases with their inhibitors. The interaction between the labelled papains and cystatins was accompanied by an increase in fluorescence emission of up to 38-fold for AANS-papain and approximately 3.5-fold for AEDANS-papain. Fluorescence titrations gave dissociation equil
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7

Lindhout, T., G. Willems, R. Blezer, and H. C. Hemker. "Kinetics of the inhibition of human factor Xa by full-length and truncated recombinant tissue factor pathway inhibitor." Biochemical Journal 297, no. 1 (January 1, 1994): 131–36. http://dx.doi.org/10.1042/bj2970131.

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The inhibition equilibrium and kinetics of association and dissociation of the binding of three types of recombinant tissue factor pathway inhibitor (TFPI), namely full-length TFPI, C-terminal-truncated TFPI, and TFPI without the third Kunitz domain (TFPI1-161), to factor Xa have been measured. Formation and dissociation of the complexes were monitored by continuous measurement of the changes in the rate of hydrolysis of a peptidyl-p-nitroanilide substrate. Progress curves of product formation were fitted to a set of equations describing a one-step bimolecular inhibitory reaction in the presen
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Ahmad, Suhail, R. K. Bhatnagar, and T. A. Venkitasubramanian. "Ornithine transcarbamylase from Mycobacterium smegmatis ATCC 14468: purification, properties, and reaction mechanism." Biochemistry and Cell Biology 64, no. 12 (December 1, 1986): 1349–55. http://dx.doi.org/10.1139/o86-177.

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Ornithine transcarbamylase (EC 2.1.3.3) has been purified 980-fold from Mycobacterium smegmatis and has a molecular weight of 116 000. Initial velocity determinations indicated that the reaction proceeds via a sequential kinetic mechanism. The limiting Michaelis constants for carbamyl phosphate (KmA) and ornithine (KmB) and the dissociation constant for carbamyl phospate (Kia) were found to be 0.20, 0.25, and 0.07 mM, respectively. Ornithine at higher concentrations acted as an uncompetitive inhibitor when carbamyl phosphate was the variable substrate. Phosphate was a competitive inhibitor wit
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9

Jin, Byung-Ju, Jay R. Thiagarajah, and A. S. Verkman. "Convective washout reduces the antidiarrheal efficacy of enterocyte surface–targeted antisecretory drugs." Journal of General Physiology 141, no. 2 (January 28, 2013): 261–72. http://dx.doi.org/10.1085/jgp.201210885.

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Secretory diarrheas such as cholera are a major cause of morbidity and mortality in developing countries. We previously introduced the concept of antisecretory therapy for diarrhea using chloride channel inhibitors targeting the cystic fibrosis transmembrane conductance regulator channel pore on the extracellular surface of enterocytes. However, a concern with this strategy is that rapid fluid secretion could cause convective drug washout that would limit the efficacy of extracellularly targeted inhibitors. Here, we developed a convection–diffusion model of washout in an anatomically accurate
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Bernal, A. López, S. Buckley, C. M. P. Rees, and J. M. Marshall. "Meclofenamate inhibits prostaglandin E binding and adenylyl cyclase activation in human myometrium." Journal of Endocrinology 129, no. 3 (June 1991): 439–45. http://dx.doi.org/10.1677/joe.0.1290439.

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ABSTRACT The effect of sodium meclofenamate on the binding of [3H]prostaglandin E2 ([3H]PGE2) to membranes from human myometrium was investigated. Meclofenamate inhibited the binding of [3H]PGE2 to high-affinity (dissociation constant 1·5 nmol/l) sites in a reversible dose-dependent manner (inhibition constant 11 μmol/l). The mechanism of inhibition was mainly competitive, but at high doses of meclofenamate (≥ 100 μmol/l) there was loss of PGE receptor sites. Of several PG synthesis inhibitors tested, only meclofenamate and, to a lesser extent, mefenamic acid had a significant inhibitory effec
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Tesis sobre el tema "Dissociation constant of inhibitor"

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Mann, Maretta Clare, and n/a. "Sialylmimetics as Potential Inhibitors fo Vibrio Cholerae Sialidase." Griffith University. Institute for Glycomics, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20061006.083947.

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Cholera is an epidemic infectious diarrhoeal disease that for centuries has proven its frightening ability to cause rapid and widespread loss of human life. All symptoms associated with cholera are a result of rapid dehydration due to infection by pathogenic strains of the bacterium Vibrio cholerae. The damaging effects associated with cholera are mainly attributed to the toxin, which is secreted by the bacterium and infects cells lining the gastrointestinal tract. A sialidase, also secreted by the bacterium, is believed to facilitate toxin uptake by the gastrointestinal epithelium. V. cholera
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Mann, Maretta Clare. "Sialylmimetics as Potential Inhibitors fo Vibrio Cholerae Sialidase." Thesis, Griffith University, 2004. http://hdl.handle.net/10072/367187.

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Cholera is an epidemic infectious diarrhoeal disease that for centuries has proven its frightening ability to cause rapid and widespread loss of human life. All symptoms associated with cholera are a result of rapid dehydration due to infection by pathogenic strains of the bacterium Vibrio cholerae. The damaging effects associated with cholera are mainly attributed to the toxin, which is secreted by the bacterium and infects cells lining the gastrointestinal tract. A sialidase, also secreted by the bacterium, is believed to facilitate toxin uptake by the gastrointestinal epithelium. V. cholera
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3

Sooväli, Lilli. "Spectrophotometric measurements and their uncertainty in chemical analysis and dissociation constant measurements /." Online version, 2006. http://dspace.utlib.ee/dspace/bitstream/10062/627/5/soovalililli.pdf.

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Ronneburg, Henrike [Verfasser], Jürgen [Akademischer Betreuer] Dittmer, and Kurt [Akademischer Betreuer] Engeland. "Prognostische Relevanz von Rho-GDP dissociation inhibitor Proteinen beim Mammakarzinom / Henrike Ronneburg. Betreuer: Jürgen Dittmer ; Kurt Engeland." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2009. http://d-nb.info/1024895807/34.

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Evangelista, Jaqueline Pesciutti. "Selenoproteínas: Seril-tRNA Sintetase e as selenoproteínas do Trypanosoma brucei." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-13112014-171709/.

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O aminoácido selenocisteína (Sec) representa a principal forma biológica de selênio sendo requerida uma complexa maquinaria molecular para sua síntese e incorporação co-traducional em selenoproteínas. A Seril-tRNA sintetase (SerRS) inicia essa via, aminoacilando o Ser-tRNASec (SelC) com uma serina e também aminoacila os tRNAsSer. Sendo assim, um dos focos deste trabalho foi estudar a interação da SerRS de Trypanosoma brucei (T. brucei) com os tRNAsSer e o SelC utilizando a técnica de anisotropia de fluorescência para determinar suas constantes de dissociação. Em Kinetoplastidae, além da via de
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Karbanová, Kateřina. "Disociační chování přírodních biokoloidů." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2017. http://www.nusl.cz/ntk/nusl-316163.

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This diploma thesis is focused on the study of dissociation behaviour of natural biocolloids, namely humic acids and fulvic acids. Humic and fulvic acids are natural, heterogeneous, high molecular weight substances which behave as weakly acidic polyelectrolytes and they have complex not exactly described structure. They are formed by biochemical transformations of organic residues (mainly plants). They are part of the soil, water, peat, sediments and coal. Solubility of humic acids is affected by pH value. The higher the pH value is the higher the solubility is. Fulvic acids are soluble in who
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Viktorinová, Jana. "Využití chronopotenciometrické titrace v huminovém výzkumu." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2013. http://www.nusl.cz/ntk/nusl-216933.

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Humic acids are natural substances belonging to the group of humic substances. They arise mainly decomposition of plant residues. They are contained in soils, peat, sediments, young coal, water and even in the air. Humic acids are only partially soluble in water with increasing pH increases their solubility. Diploma thesis focuses on the use of chronopotentiometric titration of humic research. This method is mainly used for the determination of trace concentrations of analytes. This work is focused on the determination of acidity by potentiometric titration and the determination of dissociatio
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Chaudhury, Chaity. "Identification and biochemical characterization of a novel receptor:ligand interaction between FcRn and albumin." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1110211148.

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Smallman, Matthew John. "Spatial regulation of Rho GTPase signalling during root hair development in Arabidopsis thaliana is reliant upon the guanine nucleotide dissociation inhibitor SCN1." Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496221.

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The scn1-1 mutants of Arabidopsis are characterised by spatially deregulated sites of root hair growth. This studydemonstrates that this phenotype is the result of the loss of regulation of members of the plant specific sub-family of Rho small GTPases by the Guanine nucleotide Dissociation Inhibitor (GDI), encoded by SCN1. The small GTPases R0P2, R0P4 and R0P5 of Arabidopsis are members of the I subset of type I ROPs that terminate with a conserved CXXL box and undergo 3 prenylation. These small GTPases are expressed in trichoblasts, and localize in patters suggestive of specific roles through
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Li, Muchen. "Determination of dissociation constant of DNA/DNA hybridization by three different surface techniques : comparison of surface plasmon resonance, fluorescent microarray and evanescent field fluorescence." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEC028/document.

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Les biocapteurs sont des outils de détection et d'analyse puissants qui ont été largement utilisés dans les domaines de la santé, de la recherche biomédicale et de l’environnement. Cependant, différents biocapteurs utilisent différents transducteurs qui varient par la nature des substrats utilisés et par la chimie de surface. Tous ces paramètres peuvent avoir un effet sur les réactions biomoléculaires aux interfaces et conduire à des variations de la mesure de la constante de dissociation Kd. Dans ce contexte, ce travail de thèse visait à comparer trois techniques différentes : biopuce avec un
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Libros sobre el tema "Dissociation constant of inhibitor"

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Raney, Donald C., and M. L. Gillette. Determining the Dissociation Constant of a Weak Acid Using Ph Measurements. Chemical Education Resources, 1989.

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Gillette, Marcia L., and H. Anthony Neidig. Evaluating the Dissociation Constant of a Weak Acid Using Microscale Techniques. Chemical Education Resources, 1991.

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Carter, K. N. Determining the Formula and Estimating the Dissociation Constant of a Complex Ion. Chemical Education Resources, 1994.

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Siino, Joseph S. Replacement of conserved threonines by alanine residues: Effect on the dissociation constant of recombinant human HMG-I. 1992.

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Stafford, Dan. Determiming the Equivalant Mass and Dissociation Constant of an Unknown Weak Acid by Titrimetry Modular Laboratory Program in Chemistry. Chemical Education Resources, 1990.

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Gillette, M. L., and Richard C. Bell. Determiming the Equivalant Mass and Dissociation Constant of an Unknown Weak Acid by Titrimetry Modular Laboratory Program in Chemistry. Chemical Education Resources, 1990.

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Capítulos de libros sobre el tema "Dissociation constant of inhibitor"

1

Gooch, Jan W. "Dissociation Constant." In Encyclopedic Dictionary of Polymers, 237. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_3861.

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Gooch, Jan W. "Dissociation Constant." In Encyclopedic Dictionary of Polymers, 888. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13585.

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Ellenbroek, Bart, Alfonso Abizaid, Shimon Amir, Martina de Zwaan, Sarah Parylak, Pietro Cottone, Eric P. Zorrilla, et al. "Equilibrium Dissociation Constant." In Encyclopedia of Psychopharmacology, 489–90. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_796.

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Speer, Tod W., Christin A. Knowlton, Michelle Kolton Mackay, Charlie Ma, Lu Wang, Larry C. Daugherty, Brandon J. Fisher, et al. "Dissociation Constant (Kd)." In Encyclopedia of Radiation Oncology, 157–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_675.

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Nahler, Gerhard. "acid dissociation constant." In Dictionary of Pharmaceutical Medicine, 2. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_13.

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Tallarida, Ronald J., and Rodney B. Murray. "Dissociation Constant I: Agonists." In Manual of Pharmacologic Calculations, 44–47. New York, NY: Springer New York, 1987. http://dx.doi.org/10.1007/978-1-4612-4974-0_13.

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Tallarida, Ronald J., and Rodney B. Murray. "Dissociation Constant II: Partial Agonists." In Manual of Pharmacologic Calculations, 47–50. New York, NY: Springer New York, 1987. http://dx.doi.org/10.1007/978-1-4612-4974-0_14.

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Tallarida, Ronald J., and Rodney B. Murray. "Dissociation Constant III: Perturbation Methods (Rate Constants in the Drug-Receptor Reaction)." In Manual of Pharmacologic Calculations, 50–53. New York, NY: Springer New York, 1987. http://dx.doi.org/10.1007/978-1-4612-4974-0_15.

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Yan, Dong, Tetsumei Urano, Yumiko Takada, and Akikazu Takada. "The Dissociation of α2-Plasmin-Inhibitor-Plasmin Complex to Active Plasmin by SDS Treatment." In Current Aspects of Blood Coagulation, Fibrinolysis, and Platelets, 140–43. Tokyo: Springer Japan, 1993. http://dx.doi.org/10.1007/978-4-431-68323-0_24.

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Vogel, Marc, and Beatrix Suess. "Label-Free Determination of the Dissociation Constant of Small Molecule-Aptamer Interaction by Isothermal Titration Calorimetry." In Methods in Molecular Biology, 113–25. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3197-2_9.

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Actas de conferencias sobre el tema "Dissociation constant of inhibitor"

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Visser, A., I. M. A. Verhamme, D. G. Meuleman, and G. W. K. van Dedem. "AN INDIRECT KINETIC METHOD FOR ESTIMATING THE AFFINITY BETWEEN HEPARIN AND HEPARIN COFACTOR II." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644352.

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The heparin-dependent inactivation of alpha-thrombin by heparin cofactor II was studied in buffer media with a pH ranging from 6 to 9 and an ionic strength from 0.05 M to 0.80 M. We used a heparin fraction with a mean Mr of 16,000 .The log dose response curves (logarithm of the 2nd order inactivation constant vs. the logarithm of heparin concentration) display a sigmoidal behavior. The lower and upper limiting plateau and the steepness of the ascending limb are characteristic for every pH and ionic strength. Similar log dose response curves can be observed for the heparin-mediated inactivation
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Sahari Moghaddam, Farzan, Maziyar Mahmoodi, Marziyeh Zare, Fatemeh Goodarzi, Majid Abdi, and Lesley James. "Natural Gas Hydrate Equilibria in Brine Including the Effect of Inhibitors on Hydrate Formation." In SPE Canadian Energy Technology Conference. SPE, 2022. http://dx.doi.org/10.2118/208890-ms.

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Abstract Preventing hydrate formation is critical to safely and economically manage subsea tiebacks. Thermodynamic Hydrate Inhibitors (THI) and Low Dosage Hydrate Inhibitors (LDHI) help manage hydrate formation. Here, we use a novel isothermal approach using a PVT cell to experimentally find the hydrate equilibrium point of natural gas and brine. In addition, a constant temperature and pressure condition is used to compare hydrate formation with and without hydrate inhibitors. First, to better understand the novel isothermal technique, natural gas-brine equilibrium experiments were conducted.
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Church, F. C., R. E. Treanor, and H. C. Whinna. "ACTIVATION OF HEPARIN COFACTOR II BY PHOSVITIN, A PHOSPHOGLYCO-PROTEIN, AND OTHER PHOSPHATE-CONTAINING POLYANIONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643867.

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We are characterizing the specificity of the polyanion-binding domain of the heparin/dermatan sulfate-dependent plasma protease inhibitor, heparin cofactor II (HCII). Various phosphate-containing polyanions accelerate the HCII-catalyzed inhibition of thrombin (T). Phosvitin, a phosphoprotein, enhances the HCII/T reaction at 25°C and pH 8.0 with the apparent second-order rate constant value (K2) increasing from 5 × 104 M−1 min−1 (in the absence of phosvitin) to 8 x 10' M”1 min as phosvitin increased from 0.05 to 30 ug/ml and then decreases as phosvitin is increased above 30 ug/ml. Apparent diss
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Lian, E. C. Y., and F. A. Siddigui. "BINDING OF 37-DKa PLATELET AGGLUTINATING PROTEIN TO HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643976.

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We have previously reported the purification of a 37-KDa platelet agglutinating protein (PAP p37) from the plasma of a patient with thrombotic thrombocytopenic purpura. using 125I-labeled p37, the properties of its binding to platelets were studied. The binding of p37 to washed human platelets from 4 normal subjects and two TTP patients after recovery was specific, concentration dependent and saturable. The Scatchard analysis revealed that the binding sites for p37 was about 100,000 per platelet with a dissociation constant of 48 × 10−9 M. The binding of p37 to erythrocytes was very little and
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Contant, G., J. L. Martinoli, and C. Thirion. "INFLUENCE OF PLASMINOGEN ACTIVATOR INHIBITOR (PAI) ON THE TISSUE PLASMINOGEN ACTIVATOR (tPA) ASSAY IN EUGLOBULIN FRACTIONS AND IN PLASMA." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644861.

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Current liquid-phase methods for thedetermination of tPA in plasma involve inactivation of both tPA and plasmin inhibitors by either plasma acidificationor euglobulin fractionation. In a firststep, our liquid-phase assay was performed in euglobulin fractions (EF) and the inactivation of PAI was monitored.In a second step, we studied the influenceof PAI onthe tPA assay in plasma.When EF were used (1:10 dilution, pH 5.9), the reference curve was done with tPA (0 to 1 IU/ml) diluted in buffer.The diluted samples (tPA or EF) were incubated with fibrinogen fragments as Stimulator (0.5 mg/ml), an ex
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Bakhit, C., D. Lewis, R. Billings, and B. Malfroy. "CELLULAR CATABOLISM OF RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL HIGH AFFINITY UPTAKE SYSTEM ON RAT HEPATOCYTES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644400.

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The uptake, internalization and intracellular degradation of 125I-labeled rt-PA (125I-rt-PA) by isolated rat hepatocytes was investigated. Incubation at 37°C resulted in internalization of 125I-rt-PA, followed by the appearance of labeled trichloroacetic acid-soluble (TCA) material in the inclubation media due to degradation of rt-PA. Degradation of rt-PA was inhibited by the presence of NH4Cl (10mM) or chloroquine (ImM) (lysosoma tropic agents) in the incubation media. This suggests that rt-PA degradation occurs intracellularly, perhaps within the lysosomes. 125I-rt-PA was taken up by rat hep
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7

Preissner, K. T., E. Anders, and G. Müller-Berghaus. "INTERACTION OF S PROTEIN/VITRONECTIN WITH CULTURED ENDOTHELIAL CELLS: PROMOTION OF ATTACHMENT AND SPECIFIC BINDING." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643635.

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The interaction of the complement inhibitor S protein, which is identical to the serum spreading factor, vitronectin, with cultured human endothelial cells of macro- and microvas- cular origin was investigated. Purified S protein, coated for 2 h on polystyrene petri dishes, induced concentration- and time-dependent attachment and spreading of human umbilical vein endothelial cells (HUVEC) as well as human omental tissqe microvasular endothelial cells (HOTMEC) at 37°C. With 3 × 105 cells/ml (final concentration) more than 50% of the cells attached within 2 h incubation at 0.3 - 3 μg/ml S protei
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Higashiyama, S., I. Ohkubo, H. Ishiguro, and M. Sasaki. "A NEW FUNCTION OF HUMAN KININOGENS: THE AMINO-TERMINAL REGION OF DOMAIN 1 INVOLVES AN EF HAND-LIKE STRACTURE FOR METAL BINDING." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642851.

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Two types of kininogens in mammalian plasma, high molecular weight (HMW) and low molecular weight (LMW) kininogens, are the precursors of kinin. Especially, HMW kininogen circulates in the plasma as a complex with prekallikrein and factor XI, and functions as a cofactor in the initial phase reactions of intrinsic blood coagulation cascade. Recently, it has been found that the kininogens have inhibitory activity toward cysteine proteinases. The heavy chain portion, which is identical for HMW and LMW kininogens, is composed of three domains, domain 1, 2 and 3. Each the domain 2 and 3 has a react
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LOFTUS, J. C., E. F. Plow, A. L. Frelinger III, M. A. Smith, S. D’ouza, and M. H. Ginsberg. "LOCALIZATION AND CHEMICAL SYNTHESIS OF A DIVALENT CATION REGULATED EPITOPE IN PLATELET MEMBRANE GPIIb." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643959.

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Platelet membrane glycoprotein (GP)IIb-IIIa is a component of a common adhesive protein receptor for fibrinogen, fibronectin, and von Willebrand factor. A monoclonal antibody, PMI-1, defines a divalent cation dependent regulation of the surface orientation of the heavy chain of GPIIb. Exposure of the PMI-1 epitope inversely correlates with the capacity of platelets to bind fibrinogen and aggregate. We have now localized and chemically synthesized this epitope. A 1.1 Kb cDNA clone which directs the synthesis of a fusion protein which bears the PMI-1 epitope was isolated from a lambda gt 11 expr
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Weizhen Liang, Sanjay B Shah, John J Classen, and Ratna Sharma-Shivappa. "Dissociation Constant of Ammonium and Henry's Law Constant of Ammonia in Broiler Litter." In 2011 Louisville, Kentucky, August 7 - August 10, 2011. St. Joseph, MI: American Society of Agricultural and Biological Engineers, 2011. http://dx.doi.org/10.13031/2013.37373.

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Informes sobre el tema "Dissociation constant of inhibitor"

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Shomer, Ilan, Ruth E. Stark, Victor Gaba, and James D. Batteas. Understanding the hardening syndrome of potato (Solanum tuberosum L.) tuber tissue to eliminate textural defects in fresh and fresh-peeled/cut products. United States Department of Agriculture, November 2002. http://dx.doi.org/10.32747/2002.7587238.bard.

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The project sought to understand factors and mechanisms involved in the hardening of potato tubers. This syndrome inhibits heat softening due to intercellular adhesion (ICA) strengthening, compromising the marketing of industrially processed potatoes, particularly fresh peeled-cut or frozen tubers. However, ICA strengthening occurs under conditions which are inconsistent with the current ideas that relate it to Ca-pectate following pectin methyl esterase (PME) activity or to formation of rhamnogalacturonan (RG)-II-borate. First, it was necessary to induce strengthening of the middle lamellar c
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