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Artículos de revistas sobre el tema "Disables"

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Autor: Grafiati

Publicado: 25 de julio de 2024

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1

Fardnia, Bahar, Nordin Abdul Rahman, Mohd Yazid Mohd Yunos y Md Azree Othuman Mydin. "Evaluating Mobility in Marketing Places for Entrepreneurial Disabled, Case Study: Central Market Area Kuala Lumpur". Applied Mechanics and Materials 747 (marzo de 2015): 176–79. http://dx.doi.org/10.4028/www.scientific.net/amm.747.176.

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This article is about evaluating the easy mobility in selected KL busy market places for understanding the potential of these places for disabled’s to work there independently. In this subject, mobility and safety are the tree main categories for disables to go out. Interview and observation are two methods which have been used, then supported them with photos. The results show there are many weaknesses for making the marketing places disables friendly. There are many famous and traditional marketing areas in KL which they can give opportunity to disables to start their own business. Therefore, they should define new standards to do some renovation and make new maintained schedule to give more chance to disables for starting their own independent life.

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Roza Jamal, Mrs. Wajeeha Komal y Mr. Sarfraz Ahmad. "Comparison of Life Satisfaction and Attitude towards Disability between Congenital and Acquired Physical Disabilities". sjesr 4, n.º 2 (1 de mayo de 2021): 71–81. http://dx.doi.org/10.36902/sjesr-vol4-iss2-2021(71-81).

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The most common physical deformity includes upper and lowers limbs deformity that could be acquired or congenital. Such deformity produces difficulty in daily life activities including reaching, walking, lifting, and carrying things. The present study aimed to explore life satisfaction and attitude towards disability between congenital and acquired physical disabilities. A sample of eighty (N=80) participants was included in the study out of which (n=40) were congenital and (n=40) were acquired physical disables. The sample was collected from different rehabilitation and paraplegic centers as well as institutions through the purposive sampling technique. Satisfaction with life scale and attitude toward disabled person scales were included. It was hypothesized that there will be a significant difference in terms of life satisfaction between congenital and acquired physical disables. The second hypothesis was the attitude towards disability will be positive among the congenital group than the acquired one. An independent sample t-test (IBM SPSS statistics version 20) was applied to analyze the difference between congenital and acquired physical disables. Results of the study indicated that congenital physical disabled were found with highly satisfied from their life (α=.000) and possess a positive attitude towards disability (α=.000) than the acquired physical disables.

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Berndt, J. D. "Shigella Disables Defenses". Science Signaling 7, n.º 347 (14 de octubre de 2014): ec283-ec283. http://dx.doi.org/10.1126/scisignal.aaa0468.

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Bril, Mykhailo. "Research of macroeconomic disables of Ukraine". Economics of Development 17, n.º 4 (12 de diciembre de 2018): 20–29. http://dx.doi.org/10.21511/ed.17(4).2018.03.

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The crisis in the political and economic spheres in Ukraine has led to an aggravation of macroeconomic imbalances, which in turn worsen the socio-economic situation, complicate the moments of doing business, manifestation of violations and instability in the public administration sector and social tension in society. As the result is the accumulation of macroeconomic imbalances to a critical point that threatens the normal, gradual development of economic processes that should take place in the economic space of Ukraine. The article deals with the main imbalances indicators of the country's economy and their applicability under modern Ukrainian economic policy conditions. The interconnection of the main macro-instability factors in Ukraine economy and other countries of the world is considered, which allows to identity a number of endogenous (external) and exogenous (internal) factors that create imbalances. The mechanism of imbalances detection is proposed, which combines certain categories, methods, principles and methods of their research. The simulation model for identifying macroeconomic imbalances in the Ukrainian economy was developed, based on which the dynamic properties of the macroeconomic imbalances system were investigated, a short-term indicators forecast was constructed, and assessment of the imbalances probability in the future was implemented. Forecast macroeconomic indicators were estimated that fall into critical areas also the gross external debt, changes in the real effective exchange rate, changes in the share of the export market show that external imbalances and disproportion exist. Other macro indicators that form the imbalances table, according to projected calculations, show trends that are close to the ultimate limits and instability risks which confirms the vulnerability of the country's financial and economic system. The obtained forecasting results will allow to prevent new imbalances through the timely and appropriate rapid response management action.

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Bauman, Zygmunt. "Society Enables and Disables". Scandinavian Journal of Disability Research 9, n.º 1 (enero de 2007): 58–60. http://dx.doi.org/10.1080/15017410500530068.

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6

Higgins, Leighanne. "Psycho-emotional disability in the marketplace". European Journal of Marketing 54, n.º 11 (1 de junio de 2020): 2675–95. http://dx.doi.org/10.1108/ejm-02-2019-0191.

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Purpose Through adoption of the psycho-emotional model of disability, this study aims to offer consumer research insight into how the marketplace internally oppresses and psycho-emotionally disables consumers living with impairment. Design/methodology/approach This paper draws insight from the interview data of a wider two-year interpretive research study investigating access barriers to marketplaces for consumers living with impairment. Findings The overarching contribution offers to consumer research insight into how the marketplace internally oppresses and psycho-emotionally disables consumers living with impairment. Further contributions offered by this paper: unearth the emotion of fear to be central to manifestations of psycho-emotional disability; reveal a broader understanding of the marketplace practices, and core perpetrators, that psycho-emotionally disable consumers living with impairment; and uncover psycho-emotional disability to extend beyond the context of impairment. Research limitations/implications This study adopts a UK-only perspective. However, findings uncovered that the model of psycho-emotional disability has wider theoretical value to marketing and consumer research beyond the context of impairment. Practical implications The insight offered into the precise marketplace practices that disable consumers living with impairment leads this paper to call for a revising of disability training within marketplace and service contexts. Originality/value Extending current consumer research and consumer vulnerability research on disability, the empirical adoption of the psycho-emotional model of disability is a fruitful framework for extrapolating insight into marketplace practices that internally oppress and psycho-emotionally disable consumers living with impairment.

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Cumashi, Albana, Helenia Ansuini, Nicola Celli, Antonio De Blasi, Peter O’Brien, Lawrence Brass y Marina Molino. "Neutrophil Proteases Can Inactivate Human PAR3 and Abolish the Co-receptor Function of PAR3 on Murine Platelets". Thrombosis and Haemostasis 85, n.º 03 (2001): 533–38. http://dx.doi.org/10.1055/s-0037-1615617.

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SummaryThree members of the protease-activated receptor family, PAR1, PAR3 and PAR4, are activated when thrombin cleaves the receptor N-terminus, exposing a tethered ligand. Proteases other than thrombin can also cleave PAR family members and, depending upon whether this exposes or removes the tethered ligand, either activate or disable the receptor. For example, on human platelets PAR1 is disabled by cathepsin G, although aggregation still occurs because cathepsin G can activate PAR4. The present studies examine the interaction of cathepsin G and a second neutrophil protease, elastase, with PAR3 using two model systems: COS-7 cells transfected with human PAR3 and mouse platelets, which express PAR3 and PAR4, but not PAR1. In contrast to human platelets, cathepsin G did not aggregate murine platelets, and prevented their activation only at low thrombin concentrations. Elastase had no effect on thrombin responses in mouse platelets, but when added to COS cells expressing human PAR3, both cathepsin G and elastase prevented activation of phospholipase C by thrombin. Notably, this inhibition occurred without loss of the binding sites for two monoclonal antibodies that flank the tethered ligand on human PAR3. We therefore conclude that 1) exposure to cathepsin G disables signaling through human PAR3, and prevents murine PAR3 from serving its normal role, which is to facilitate PAR4 cleavage at low thrombin concentrations, 2) elastase disables human, but not murine, PAR3, 3) in contrast to human PAR4, mouse PAR4 will not support platelet aggregation in response to cathepsin G, and 4) the inactivation of human PAR3 by cathepsin G and elastase involves a mechanism other than amputation of the tethered ligand domain. These results extend the range of possible interactions between PAR family members and proteases, and provide further support for species-specific differences in the interaction of these receptors with proteases other than thrombin.

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Seppa, Nathan. "Enzyme Disables Excess Amino Acid". Science News 155, n.º 11 (13 de marzo de 1999): 164. http://dx.doi.org/10.2307/4011114.

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Fernandez, Mario R., Franz X. Schaub, Chunying Yang, Weimin Li, Seongseok Yun, Stephanie K. Schaub, Frank C. Dorsey et al. "Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy". Cancer Research 82, n.º 7 (11 de febrero de 2022): 1234–50. http://dx.doi.org/10.1158/0008-5472.can-21-1168.

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Abstract MYC family oncoproteins are regulators of metabolic reprogramming that sustains cancer cell anabolism. Normal cells adapt to nutrient-limiting conditions by activating autophagy, which is required for amino acid (AA) homeostasis. Here we report that the autophagy pathway is suppressed by Myc in normal B cells, in premalignant and neoplastic B cells of Eμ-Myc transgenic mice, and in human MYC-driven Burkitt lymphoma. Myc suppresses autophagy by antagonizing the expression and function of transcription factor EB (TFEB), a master regulator of autophagy. Mechanisms that sustained AA pools in MYC-expressing B cells include coordinated induction of the proteasome and increases in AA transport. Reactivation of the autophagy-lysosomal pathway by TFEB disabled the malignant state by disrupting mitochondrial functions, proteasome activity, AA transport, and AA and nucleotide metabolism, leading to metabolic anergy, growth arrest, and apoptosis. This phenotype provides therapeutic opportunities to disable MYC-driven malignancies, including AA restriction and treatment with proteasome inhibitors. Significance: MYC suppresses TFEB and autophagy and controls amino acid homeostasis by upregulating amino acid transport and the proteasome, and reactivation of TFEB disables the metabolism of MYC-driven tumors.

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Bianchi, Piervito, Giulio Mario Cappelletti, Elisabetta Mafrolla, Edgardo Sica y Roberta Sisto. "Accessible Tourism in Natural Park Areas: A Social Network Analysis to Discard Barriers and Provide Information for People with Disabilities". Sustainability 12, n.º 23 (27 de noviembre de 2020): 9915. http://dx.doi.org/10.3390/su12239915.

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Although regulations designed to meet the necessities of tourists with disabilities are allowing disables to travel more, they are still encountering barriers and discriminatory practices. A relevant obstacle in making the tourist policy effective is represented by the lack of information and communication about needs and expectations of disabled categories. In this context, the present paper focuses on the coproduction process of tourist public policies for disables by looking at the network that facilitates communication among the actors taking part in the process. We adopt the Social Network Analysis (SNA) to study the policy network, i.e., how public administrations and policy users (associations of citizens/people with disabilities and entrepreneurs) exchange information about the accessibility to the Gargano National Park, a protected natural area in the South of Italy. In particular, we investigate the role of entrepreneurial stakeholders in channeling information and the presence of policy brokers, i.e., stakeholders that spread the policies to the whole network. Our findings show that a limited number of actors involved in granting accessibility to tourists with disabilities is engaged in information exchanges. Moreover, information flows are guided by only one public administration that plays, therefore, a key role in the implementation of policies that support the parks’ accessibility.

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11

Ghavam, Fatemeh, Ahmad Ali Noorbala y Mohsen Rahimnia. "Designing Proper Dishes for Quadriplegic Disables". Archives of Neuroscience 1, n.º 2 (23 de octubre de 2013): 67–70. http://dx.doi.org/10.5812/archneurosci.12477.

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Hayashi, Yoshio. "Disables Ages Pearsons and Human Interface". TRENDS IN THE SCIENCES 5, n.º 7 (2000): 82–84. http://dx.doi.org/10.5363/tits.5.7_82.

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Travis, J. "Viral Protein Disables a Cellular Alarm". Science News 150, n.º 17 (26 de octubre de 1996): 261. http://dx.doi.org/10.2307/3980283.

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Robinson, Richard. "Plant Antiviral Defense Disables Other Defenders". PLOS Biology 13, n.º 12 (22 de diciembre de 2015): e1002327. http://dx.doi.org/10.1371/journal.pbio.1002327.

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15

Winland-Brown, Jill E. y Carole Pohl. "Administratorsʼ Attitudes Toward Hiring Disables Nurses". JONA: The Journal of Nursing Administration 20, n.º 4 (abril de 1990): 24–27. http://dx.doi.org/10.1097/00005110-199004000-00006.

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Jaffer, Sadaf. "Racialized Bodies, Disabling Worlds". American Journal of Islam and Society 26, n.º 4 (1 de octubre de 2009): 129–31. http://dx.doi.org/10.35632/ajis.v26i4.1374.

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Parin Dossa’s book on the lives of Canadian Muslims provides insightinto the personal stories of women who must grapple with disability in theirdaily lives. It is, therefore, located at the intersection of race, gender, and disabilitystudies and has broad social implications.In her introduction, Dossa discusses the 1967 change in Canadian immigrationpolicies that made immigration easier for a pool of skilled laborersneeded to fill jobs in the economy. Though this search for skilled labor isposited as objective, these policies are biased as regards the relative valueof different bodies. Disabled bodies are valued less in this system. Racialbiases make the situation of racialized disabled people even more difficult.Dossa’s project seeks to investigate the experience of a racialized body ina world that disables. To counter this external lack of value, the women featuredcreate an alternative space of self-value through storytelling ...

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17

Williamson, K. Eliza, Cíntia Engel y Helena Fietz. "The Chronicity of Home-Making: Women Caregivers in Dis/Abling Spaces". Space and Culture 26, n.º 3 (14 de julio de 2023): 468–82. http://dx.doi.org/10.1177/12063312231181534.

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Care for disabled family members in Brazil has historically been concentrated in the home, but the Covid-19 pandemic has intensified domestic care labor by limiting infrastructures of care. Drawing on ethnographic fieldwork with women caring for disabled others at different stages of life in three regions of Brazil, we advance two interconnected concepts that emerged in our interlocutors’ narratives. We contend that the Covid-19 pandemic has engendered a chronification of home-making, which intensified a long-standing pattern of unequally gendered labor in maintaining arrangements of spaces, people, and things. In the context of the progressive loss of social safety nets and deepening social inequality, this chronicified process of home-making also gives rise to dis/abling care—care that simultaneously enables others and disables caregivers. Our work demonstrates how the pandemic is re-entrenching historical inequalities in Brazil and how disability is produced in pandemic times.

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18

Chansangsri, Nuttachart y Natcha Thawesaengskulthai. "Automatic Wheelchair for Dog with Two Disabled Hind Legs". Applied Mechanics and Materials 778 (julio de 2015): 229–34. http://dx.doi.org/10.4028/www.scientific.net/amm.778.229.

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Currently, the wheelchair for disabled dog does not provide the best performance and for therapy dog effectively. The purpose is to clarify the key components which allow the develop an innovation product for dogs with two disables hind legs, especially dogs in Thailand, which can be domestically produced domestically and can meet the needs of users at an appropriate to the physical dog. This study contributes to the disability dogs for physical therapy and healing the pain literature by extending existing theory on new product development. Research methodology is divided into 3 steps: literature review, framework building and action research. The finding is important for management of organization strategies regarding the innovation development product for relevant industries.

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19

Torrens, Gabriel, Irina Sánchez-Diener, Elena Jordana-Lluch, Isabel María Barceló, Laura Zamorano, Carlos Juan y Antonio Oliver. "In Vivo Validation of Peptidoglycan Recycling as a Target to Disable AmpC-Mediated Resistance and Reduce Virulence Enhancing the Cell-Wall–Targeting Immunity". Journal of Infectious Diseases 220, n.º 11 (20 de julio de 2019): 1729–37. http://dx.doi.org/10.1093/infdis/jiz377.

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Abstract Background Searching for new strategies to defeat Pseudomonas aeruginosa is of paramount importance. Previous works in vitro showed that peptidoglycan recycling blockade disables AmpC-dependent resistance and enhances susceptibility against cell-wall–targeting immunity. Our objective was to validate these findings in murine models. This study shows for the first time in different murine models of infection that blocking the peptidoglycan recycling in Pseudomonas aeruginosa causes an important virulence impairment and disables AmpC-mediated resistance, being hence validated as a promising therapeutic target. Methods Wildtype PAO1, recycling-defective AmpG and NagZ mutants, an AmpC hyperproducer dacB mutant, and their combinations were used to cause systemic/respiratory infections in mice. Their survival, bacterial burden, inflammation level, and effectiveness of ceftazidime or subtherapeutic colistin to treat the infections were assessed. Results Inactivation of AmpG or NagZ significantly attenuated the virulence in terms of mice mortality, bacterial load, and inflammation. When inactivating these genes in the dacB-defective background, the β-lactam resistance phenotype was abolished, disabling the emergence of ceftazidime-resistant mutants, and restoring ceftazidime for treatment. Subtherapeutic colistin was shown to efficiently clear the infection caused by the recycling-defective strains, likely due to the combined effect with the mice cell-wall– targeting immunity. Conclusions This study brings us one step closer to new therapies intended to disable P. aeruginosa AmpC-mediated resistance and dampen its virulence, and strongly support the interest in developing efficient AmpG and/or NagZ inhibitors.

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Shi, Jian, Adam J. Hyman, Dario De Vecchis, Jiehan Chong, Laeticia Lichtenstein, T. Simon Futers, Myriam Rouahi et al. "Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels". Cell Reports 33, n.º 1 (octubre de 2020): 108225. http://dx.doi.org/10.1016/j.celrep.2020.108225.

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Prince, Stuart y Maija Hollmén. "Dimeric IgA specifically disables intracellular mutated oncodrivers". Immunity 56, n.º 11 (noviembre de 2023): 2461–63. http://dx.doi.org/10.1016/j.immuni.2023.10.014.

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Liang, Junyan, Ling He, Yanyan Zuo, Zhaoyu Chen y Tao Peng. "An insight into the amphiphobicity and thermal degradation behavior of PDMS-based block copolymers bearing POSS and fluorinated units". Soft Matter 14, n.º 25 (2018): 5235–45. http://dx.doi.org/10.1039/c8sm00608c.

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Lucas, Christina y Johan Lauwereyns. "Selective Working Memory Disables Inhibition of Visual Features". Experimental Psychology 54, n.º 4 (enero de 2007): 256–63. http://dx.doi.org/10.1027/1618-3169.54.4.256.

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Abstract. Recent research suggests that information held in working memory can facilitate subsequent attentional processing. Here, we explore the negative corollary of this conception: Under which circumstances does information in working memory disrupt subsequent processing? Seventy participants performed visual discriminations in a dual-task paradigm. They were asked to judge colors or shapes in an online attention task under three different working-memory conditions: Same, Switch, or Unknown. In the Same condition, participants selectively maintained one visual feature in working memory, from the same dimension as in the online attention task. In the Switch condition, participants selectively maintained one visual feature in working memory, but had to focus on another visual dimension in the online attention task. In the Unknown condition, participants could not predict which visual feature would be relevant for the working-memory task. We found that irrelevant features in the online attention task were particularly difficult to ignore in the Switch condition, that is, when the irrelevant features belong to a visual dimension that is simultaneously prioritized in selective working memory. The findings are consistent with accounts in terms of neural overlap between working-memory and attention circuits, and suggest that mechanisms of selection, rather than resource limitations, critically determine the extent of visual interference.

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24

Fort, Douglas J. "Boron Deficiency Disables Xenopus laevis Oocyte Maturation Events". Biological Trace Element Research 85, n.º 2 (2002): 157–69. http://dx.doi.org/10.1385/bter:85:2:157.

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Gillespie, Diane. "Help that Disables: The Paradox of Conventional Goodness". Affilia 2, n.º 2 (junio de 1987): 7–22. http://dx.doi.org/10.1177/088610998700200203.

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Woodman, Isabel. "TNF disables TREG-cell function through FOXP3 modification". Nature Reviews Rheumatology 9, n.º 4 (26 de febrero de 2013): 197. http://dx.doi.org/10.1038/nrrheum.2013.28.

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Boguszewski, Dariusz, Jakub Grzegorz Adamczyk, Andrzej Ochal, Beata Kurkowska y Krzysztof Kamiński. "Evaluation of chosen health behaviors of disabled athletes". Advances in Rehabilitation 25, n.º 4 (1 de diciembre de 2011): 57–62. http://dx.doi.org/10.2478/rehab-2013-0021.

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Abstract Introduction: A purpose of the work was diagnosis of chosen lifestyle elements of disabled athletes, compared to inactive disabled persons, characterized by similar kind and the degree of disability. Material and methods: The questionnaire survey was conducted on 150 disabled persons (31 women; 119 men), from among 98 were active athletes (wheelchair fencing n=32; wheelchair rugby n=31; table tennis n=14; basketball n=9 and other disciplines n=12). Totally 52 inactive disabled persons were in a control group. Juczyński’s Inventory of Healthy Behavior (IHB - where health behaviors are being judged in four categories: eating habits, preventive behaviors, the psychological attitude and health practice) and an author's questionnaire about lifestyle were used as a research tool. Results: Results show that physically active persons are paying the greater attention to healthy lifestyle than non-active. The total rate of health behaviors (HBR) was higher in the group of athletes (p=0.071). The biggest differences (p=0.000) were noted in eating habits and the smallest in preventive behaviors (p=0.408). Disabled athletes more easily cope with typical problems of the everyday life (like architectural barriers, social isolation). Also they have more often undertake paid work and take part in other fields (culture, tourism). Conclusions: During examination a positive effect of the practicing sport on health behaviors, the frame of mind, self-assessment and participation in the social and professional life was proved. So it seems reasonable to promote sport and physical activity among disables people.

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Pandey, Shubham, Shubham Chandewar y Krishnamoorthy A. "Smart Assisted Vehicle for Disabled/Elderly using Raspberry Pi". International Journal of Reconfigurable and Embedded Systems (IJRES) 6, n.º 2 (28 de mayo de 2018): 82. http://dx.doi.org/10.11591/ijres.v6.i2.pp82-87.

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<p>Independent mobility is a key component in maintaining the physical and psychosocial health of an individual. Further, for people e having disabled/elderly, independent mobility increases vocational and educational opportunities, reduces dependence on caregivers and family members, and promotes feelings of self-reliance. Psychologically, a decrease in mobility can lead to feelings of emotional loss, anxiety, depression, educed self-esteem, social isolation, stress, and fear of abandonment. Even though the benefits of powered mobility are well documented, the safety issues associated with operation of powered vehicles often prevent clinicians and rehabilitation practitioners from prescribing powered mobility. So we are introducing an intelligent vehicle for disables/elderly people which uses an array of sensors to help with the movement of the vehicle with minimal human interaction. Functionalities of the proposed system are further enhanced using android interface connect to the vehicle via Bluetooth.</p>

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Dreher, Maximilian y Gregor Witte. "Selective saturation of step-edges as a tool to control the growth of molecular fibres". Physical Chemistry Chemical Physics 23, n.º 13 (2021): 8023–29. http://dx.doi.org/10.1039/d0cp06725c.

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The formation of molecular fibres is often hampered by defects such as step edges, which act as nucleation sites. Here, we present a concept of how exposure of the support to oxygen or even air disables the formation of such defect-driven fibres.

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홍성표 y 정진철. "The Effect of Possessing Certificate has on Disables Reemployment". Disability & Employment 25, n.º 3 (agosto de 2015): 169–96. http://dx.doi.org/10.15707/disem.2015.25.3.008.

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"Protein Disables P53, Drives Breast Cells Toward Cancer Transition". International Journal of Cancer Research 7, n.º 1 (15 de diciembre de 2010): 97–98. http://dx.doi.org/10.3923/ijcr.2011.97.98.

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Yang, Won Ho, Douglas M. Heithoff, Peter V. Aziz, Markus Sperandio, Victor Nizet, Michael J. Mahan y Jamey D. Marth. "Recurrent infection progressively disables host protection against intestinal inflammation". Science 358, n.º 6370 (21 de diciembre de 2017): eaao5610. http://dx.doi.org/10.1126/science.aao5610.

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Yi, Jason J., Janet Berrios, Jason M. Newbern, William D. Snider, Benjamin D. Philpot, Klaus M. Hahn y Mark J. Zylka. "An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A". Cell 162, n.º 4 (agosto de 2015): 795–807. http://dx.doi.org/10.1016/j.cell.2015.06.045.

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Alfayez, Fayez y Surbhi Bhatia Khan. "User-centric secured smart virtual assistants framework for disables". Alexandria Engineering Journal 95 (mayo de 2024): 59–71. http://dx.doi.org/10.1016/j.aej.2024.03.033.

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Dong, Liyong, Xiaoyu Guan, Ningning Li, Fan Zhang, Yuwei Zhu, Kuan Ren, Ling Yu et al. "An anti-CRISPR protein disables type V Cas12a by acetylation". Nature Structural & Molecular Biology 26, n.º 4 (abril de 2019): 308–14. http://dx.doi.org/10.1038/s41594-019-0206-1.

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Hughes, Rhidian. "It is society that disables a person, not their impairment". British Journal of Healthcare Assistants 8, n.º 2 (febrero de 2014): 98–99. http://dx.doi.org/10.12968/bjha.2014.8.2.98.

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van Tetering, Geert, Niels Bovenschen, Jan Meeldijk, Paul J. van Diest y Marc Vooijs. "Cleavage of Notch1 by granzyme B disables its transcriptional activity". Biochemical Journal 437, n.º 2 (28 de junio de 2011): 313–22. http://dx.doi.org/10.1042/bj20110226.

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Granzyme-mediated cell death is the main pathway for cytotoxic lymphocytes to kill virus-infected and tumour cells. A major player in this process is GrB (granzyme B), which triggers apoptosis in both caspase-dependent and caspase-independent pathways. A caspase-independent substrate of GrB is the highly conserved transmembrane receptor Notch1. The GrB cleavage sites in Notch1 and functional consequences of Notch1 cleavage by GrB were unknown. In the present study, we confirmed that Notch1 is a direct and caspase-independent substrate of GrB. We demonstrate that GrB cleaved the intracellular Notch1 domain at least twice at two distinct aspartic acids, Asp1860 and Asp1961. GrB cleavage of Notch1 can occur in all subcellular compartments, during maturation of the receptor, at the membrane, and in the nucleus. GrB also displayed perforin-independent functions by cleaving the extracellular domain of Notch1. Overall, cleavage of Notch1 by GrB resulted in a loss of transcriptional activity, independent of Notch1 activation. We conclude that GrB disables Notch1 function, probably resulting in anti-cellular proliferation and cell death signals.

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Lee, Jinhwa, Natalie King y Daniel J. Kosman. "Oxidative stress in Saccharomyces cerevisiae disables kinase-dependent transcriptional control". Free Radical Biology and Medicine 15, n.º 5 (noviembre de 1993): 548. http://dx.doi.org/10.1016/0891-5849(93)90476-b.

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39

Blair, K. M., L. Turner, J. T. Winkelman, H. C. Berg y D. B. Kearns. "A Molecular Clutch Disables Flagella in the Bacillus subtilis Biofilm". Science 320, n.º 5883 (20 de junio de 2008): 1636–38. http://dx.doi.org/10.1126/science.1157877.

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40

Webster, Rose P., Stephen Macha, Diane Brockman y Leslie Myatt. "Peroxynitrite treatmentin vitro disables catalytic activity of recombinant p38 MAPK". PROTEOMICS 6, n.º 17 (septiembre de 2006): 4838–44. http://dx.doi.org/10.1002/pmic.200600176.

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41

Sarker, Mahfuzur R., Marie-Paule Sory, Aoife P. Boyd, Maite Iriarte y Guy R. Cornelis. "LcrG is Required for Efficient Translocation ofYersinia Yop Effector Proteins into Eukaryotic Cells". Infection and Immunity 66, n.º 6 (1 de junio de 1998): 2976–79. http://dx.doi.org/10.1128/iai.66.6.2976-2979.1998.

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ABSTRACT Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrGmutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.

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42

Watson, Nick y Brian Woods. "No Wheelchairs Beyond this Point: A Historical Examination of Wheelchair Access in the Twentieth Century in Britain and America". Social Policy and Society 4, n.º 1 (enero de 2005): 97–105. http://dx.doi.org/10.1017/s1474746404002222.

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On the surface, the wheelchair appears a simple machine: its function seemingly apparent and its workings relatively uncomplicated. Yet, despite this apparent simplicity, the wheelchair is a complex artefact imbued with a myriad of social as well as technical relations that act simultaneously to exclude and include, confine and liberate, shape and be shaped. The wheelchair's inextricable links to injury and illness have certainly shaped its definition as a medical device. Such a definition has labelled the occupier as passive or ill and shaped a wider understanding of the machine as a prison. Wheelchair users, however, perceive the machine as a means to independence: it enables rather than disables. We present evidence here to suggest that this is not a recent phenomenon as we show how wheelchair access has been on the political agenda for disabled people for most of the twentieth century. The paper also examines the role of the wheelchair in the development of this movement, and we suggest that, as the design of the wheelchair improved, so the demand for better access increased. The final section of the paper looks at how poorly the state and its agents understood the issue of access.

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43

Berglund, Anders E., Kristen E. N. Scott, Weimin Li, Chunying Yang, Mario R. Fernandez, Franz X. Schaub, John L. Cleveland y Robert J. Rounbehler. "Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function". Oncotarget 7, n.º 50 (5 de noviembre de 2016): 83462–75. http://dx.doi.org/10.18632/oncotarget.13128.

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44

Placais, P. Y. y T. Preat. "To Favor Survival Under Food Shortage, the Brain Disables Costly Memory". Science 339, n.º 6118 (24 de enero de 2013): 440–42. http://dx.doi.org/10.1126/science.1226018.

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45

Khaperskyy, Denys A., Mohamed M. Emara, Benjamin P. Johnston, Paul Anderson, Todd F. Hatchette y Craig McCormick. "Influenza A Virus Host Shutoff Disables Antiviral Stress-Induced Translation Arrest". PLoS Pathogens 10, n.º 7 (10 de julio de 2014): e1004217. http://dx.doi.org/10.1371/journal.ppat.1004217.

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46

Ainsworth, T. D., S. F. Heron, J. C. Ortiz, P. J. Mumby, A. Grech, D. Ogawa, C. M. Eakin y W. Leggat. "Climate change disables coral bleaching protection on the Great Barrier Reef". Science 352, n.º 6283 (14 de abril de 2016): 338–42. http://dx.doi.org/10.1126/science.aac7125.

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47

Sharma, Vasundhara, Lanzhu Yue, Nathan P. Horvat, Agni Christodoulidou, Afua Adutwumwa Akuffo, Mathew Beatty, Cem Murdun et al. "Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms". Blood 134, Supplement_1 (13 de noviembre de 2019): 474. http://dx.doi.org/10.1182/blood-2019-127235.

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Introduction: Acetylated histone and non-histone proteins are pharmacologic targets for both solid and hematological cancers including myeloproliferative neoplasms (MPNs), a group of clonal hematological malignancies driven by aberrant JAK2/STAT signaling. MPNs are characterized by epigenetic alterations, including aberrant acetylation, which makes this disease particularly interesting for targeting with HDAC inhibitors. Four classes of histone deacetylases (Class I-IV HDACs) regulate gene transcription and modulate cellular processes that drive the initiation and progression of cancer. Pan-HDAC and class I-selective HDAC inhibitors have gained traction in clinical settings, yet we reasoned that specific targeting of the 18 distinct HDAC proteins may establish roles for select HDACs as therapeutic vulnerabilities in MPNs. Methods: To explore the roles of individual HDACs in MPN, we first conducted an inhibitor screen of compounds having distinct HDAC selectivity based on electrophoretic mobility shift assays with full-length human HDAC proteins expressed in baculovirus and unique peptide substrates. Ultra-specific HDAC6 compounds were initially targeted for analysis based on its previously defined role in HSP90-mediated JAK2 stabilization and translation. Survival of MPN cell line models, MPN patient samples, leukemia cell lines, and MPN disease progression in mice transplanted with Hdac6-/-, and Hdac11-/- hematopoietic stem cells (HSCs) transduced with the MPLW515L oncogene, as well as Tg-Hdac11-eGfp mice were used to show the role of HDAC6 and HDAC11 in oncogene-driven and homeostatic hematopoiesis. As further proof of specificity, HDAC6 and HDAC11 were genetically ablated in MPN model cell lines using either RNA interference or inducible shRNA. For HDAC11 substrate identification, a combination of RNA-seq, acetylated proteome (SILAC), global metabolomics (LC-MS), Seahorse metabolic assays (Agilent Technologies), enzymatic assays, and acetylation-specific immunoblotting and mutation profiling were performed (Fig. 1). Results: Despite the established interplay between HDAC6, HSP90 and JAK2, neither a highly selective HDAC6 inhibitor, HDAC6 silencing, nor the Hdac6 deficiency suppressed MPN pathogenesis, although there were clear effects on the acetylation of α-tubulin, a well characterized HDAC6-selective substrate. Intriguingly, both inhibition of HDAC11 activity with highly-specific HDAC11 inhibitors and silencing HDAC11 using an inducible validated shRNA, identified HDAC11 as a therapeutic vulnerability for multiple human MPN cell lines. The Tg-Hdac11-eGFP reporter mice showed that HDAC11 is expressed in several hematopoietic cell types, including myeloid cells, erythroblasts, and megakaryocytes. Thus, Hdac11-/- and Hdac11+/+MPLWT bone marrow were examined for steady-state hematopoiesis and transplantation chimerism. These studies demonstrated that HDAC11 does not contribute to homeostatic or transplantated bone marrow reconstitution. However, in the oncogenic MPL model, recipient mice transplanted withoncogenic MPLW515L-expressing Hdac11-deficient HSCs displayed markedly impaired cytokine-independent colony-formation, had less fibrosis, and displayed improved survival in primary and secondary MPN hematopoietic stem cell transplantation; thus HDAC11 contributes to MPN pathogenesis (Fig. 1). Studies in additional leukemia cell lines, including THP-1, HL-60, and mantle lymphoma cell lines, but not in Ramos or K562 cells, established that HDAC11 contributes to oncogene-driven events in other cell types. Mechanistically, RNA-seq, SILAC proteomics, and metabolic profiling revealed that HDAC11 controls aerobic glycolysis by deacetylating Lys343 of the glycolytic enzyme enolase-1 (ENO1), functionally inactivating ENO1. Finally, the effects of targeting HDAC11 on metabolism were augmented by blocking compensatory pathways of oxidative phosphorylation that are induced via JAK2V617Fand MPLW515L oncogenic signaling. Conclusions: Our comprehensive screens of HDAC inhibitors, coupled with our biological, in vivo and molecular studies, indicate that HDAC11 is an attractive and potent target for disabling MPN metabolism and pathogenesis. These finding support the rationale for further development of clinical HDAC11 inhibitors for the treatment of metabolically-active cancers such as MPNs. Disclosures Pinilla Ibarz: Teva: Consultancy; TG Therapeutics: Consultancy; Sanofi: Speakers Bureau; Bayer: Speakers Bureau; Novartis: Consultancy; Bristol-Myers Squibb: Consultancy; Abbvie: Consultancy, Speakers Bureau; Takeda: Consultancy, Speakers Bureau; Janssen: Consultancy, Speakers Bureau. Reuther:Incyte Corporation: Research Funding. Levine:Loxo: Membership on an entity's Board of Directors or advisory committees; Roche: Consultancy, Research Funding; Lilly: Honoraria; C4 Therapeutics: Membership on an entity's Board of Directors or advisory committees; Isoplexis: Membership on an entity's Board of Directors or advisory committees; Imago Biosciences: Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy; Gilead: Consultancy; Celgene: Consultancy, Research Funding; Qiagen: Membership on an entity's Board of Directors or advisory committees; Prelude Therapeutics: Research Funding; Amgen: Honoraria. Verma:BMS: Research Funding; Janssen: Research Funding; Stelexis: Equity Ownership, Honoraria; Acceleron: Honoraria; Celgene: Honoraria. Epling-Burnette:Incyte Corporation: Research Funding; Celgene Corporation: Patents & Royalties, Research Funding; Forma Therapeutics: Research Funding.

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48

Kristensen, Colleen N., Karin M. Bystol, Boran Li, Lourdes Serrano y Mark A. Brenneman. "Depletion of DSS1 protein disables homologous recombinational repair in human cells". Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 694, n.º 1-2 (10 de diciembre de 2010): 60–64. http://dx.doi.org/10.1016/j.mrfmmm.2010.08.007.

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Bader, A. G. y P. K. Vogt. "Phosphorylation by Akt disables the anti-oncogenic activity of YB-1". Oncogene 27, n.º 8 (20 de agosto de 2007): 1179–82. http://dx.doi.org/10.1038/sj.onc.1210719.

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Dulon, Sophie, Dominique Leduc, Graeme S. Cottrell, Jacques D'Alayer, Kristina K. Hansen, Nigel W. Bunnett, Morley D. Hollenberg, Dominique Pidard y Michel Chignard. "Pseudomonas aeruginosaElastase Disables Proteinase-Activated Receptor 2 in Respiratory Epithelial Cells". American Journal of Respiratory Cell and Molecular Biology 32, n.º 5 (mayo de 2005): 411–19. http://dx.doi.org/10.1165/rcmb.2004-0274oc.

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