Tesis sobre el tema "Dendrimers"
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Wang, Yang. "Novel amphiphilic dendrimers as nanovectors for siRNA delivery". Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4017.
Texto completoDendrimers, a special family of synthetic polymers, emerge as appealing nanovectors for drug delivery thanks to their unique precisely-controlled achitecture along with multivalency and cooperativity confined within a nanosized volume. Our group has recently demonstrated that small amphiphilic dendrons could self-assemble into supramolecular dendrimers, which mimick the covalently constructed high generation dendrimers and effectively deliver siRNA therapeutics in vitro and in vivo. In order to further explore novel amphiphilic dendrimers with special self-assembly properties for nucleic acid delivery, in this Ph.D thesis, I have synthesized and characterized two families of amphiphilic dendrimers, namely bola-amphiphilic PAMAM dendrimer and biodegradable amphiphilic poly(aminoester) dendrimer. Their physico-chemical properties and biological activity for siRNA delivery have been investigated. Our results demonstrate that they may constitute, via supramolecular self-assembling, effective and promising nanocarriers for nuclide acid delivery, in which we are actively pursuing our effort
Deakin, Peter C. "Optoelectronic dendrimers". Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510945.
Texto completoFrampton, Michael John. "Electroluminescent dendrimers". Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270614.
Texto completoHuang, Adela Ya-Ting. "Advancing dendrimer synthesis : solid-phase and self-assembly approach". Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0146.
Texto completoDendrimers hold great promise for wide applications thanks to their unique structural architecture and multivalent cooperativity. However, dendrimer synthesis often suffers from structural defects caused by incomplete reactions and difficulties associated with purification. Consequently, alternative synthetic approaches to overcome the limitations of current dendrimer synthesis are in high demand.My first PhD project mainly focuses on establishing novel strategies and methodologies for solid-phase dendrimer synthesis with advantages of convenient complete synthesis and easy purification procedures. We first developed a new and concise solid-phase synthesis of PAMAM dendrimers based on the adoption of peptide synthesis chemistry. We then constructed a small library of triazine dendrimers varying in generations and surface groups with a view to rapidly synthesizing dendrimers with structural diversity. We also strived to synthesize poly(aminoester) dendrimers although we had difficult to get it thorough.My second PhD program aims to apply the self-assembly approach for constructing supramolecular dendrimer theranostics. A small DOTA-conjugated amphiphilic dendrimer with Gd(III)-chelation was synthesized and self-assembled into supramolecular nanomicelles to encapsulate the anticancer drug doxorubicin. The obtained system constitutes a multivalent nanotheranostic to combine imaging purpose with therapeutic utility.In summary, my PhD program mainly contributes to elaborating strategies for dendrimer synthesis using both solid-phase method and self-assembly approach in the view to realizing and broadening their applications in the arenas of biomedical and material sciences
Wang, Yang. "Novel amphiphilic dendrimers as nanovectors for siRNA delivery". Electronic Thesis or Diss., Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4017.
Texto completoDendrimers, a special family of synthetic polymers, emerge as appealing nanovectors for drug delivery thanks to their unique precisely-controlled achitecture along with multivalency and cooperativity confined within a nanosized volume. Our group has recently demonstrated that small amphiphilic dendrons could self-assemble into supramolecular dendrimers, which mimick the covalently constructed high generation dendrimers and effectively deliver siRNA therapeutics in vitro and in vivo. In order to further explore novel amphiphilic dendrimers with special self-assembly properties for nucleic acid delivery, in this Ph.D thesis, I have synthesized and characterized two families of amphiphilic dendrimers, namely bola-amphiphilic PAMAM dendrimer and biodegradable amphiphilic poly(aminoester) dendrimer. Their physico-chemical properties and biological activity for siRNA delivery have been investigated. Our results demonstrate that they may constitute, via supramolecular self-assembling, effective and promising nanocarriers for nuclide acid delivery, in which we are actively pursuing our effort
Huang, Adela Ya-Ting. "Advancing dendrimer synthesis : solid-phase and self-assembly approach". Electronic Thesis or Diss., Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0146.
Texto completoDendrimers hold great promise for wide applications thanks to their unique structural architecture and multivalent cooperativity. However, dendrimer synthesis often suffers from structural defects caused by incomplete reactions and difficulties associated with purification. Consequently, alternative synthetic approaches to overcome the limitations of current dendrimer synthesis are in high demand.My first PhD project mainly focuses on establishing novel strategies and methodologies for solid-phase dendrimer synthesis with advantages of convenient complete synthesis and easy purification procedures. We first developed a new and concise solid-phase synthesis of PAMAM dendrimers based on the adoption of peptide synthesis chemistry. We then constructed a small library of triazine dendrimers varying in generations and surface groups with a view to rapidly synthesizing dendrimers with structural diversity. We also strived to synthesize poly(aminoester) dendrimers although we had difficult to get it thorough.My second PhD program aims to apply the self-assembly approach for constructing supramolecular dendrimer theranostics. A small DOTA-conjugated amphiphilic dendrimer with Gd(III)-chelation was synthesized and self-assembled into supramolecular nanomicelles to encapsulate the anticancer drug doxorubicin. The obtained system constitutes a multivalent nanotheranostic to combine imaging purpose with therapeutic utility.In summary, my PhD program mainly contributes to elaborating strategies for dendrimer synthesis using both solid-phase method and self-assembly approach in the view to realizing and broadening their applications in the arenas of biomedical and material sciences
Liang, Liyuan. "Inorganic Aspects of “Click” Chemistry in Polymers and Dendrimers : synthesis, Nanoparticle Stabilization and Catalysis". Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14277/document.
Texto completoThe thesis concerns aspects of inorganic reaction between organic azides and terminal alkynes, the main “click” reactions. Catalysis of this reaction by copper (I)-centered dendrimers allowed us to highlight the dendritic effects originals. The dendritic and polymeric functional assemblies produced using the "click" reaction, especially with carboranes, led us to the stabilization of gold nanoparticles and palladium from cation-coordinated "click" triazole. The highly efficient catalysis in aqueous medium under ambient conditions of formation of carbon-carbon was carried out using very small amounts of stabilized palladium nanoparticles
Wang, Qi. "Synthesis of multi-functional dendrimers for targeted delivery of nucleic acids". Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4068/document.
Texto completoWe have demonstrated that structurally flexible poly(amido)amine (PAMAM) dendrimers are efficient siRNA delivery system in vitro and in vivo recently. We would like to undertake further investigation on targeted siRNA delivery using dendrimers conjugated with specific ligands or antibodies, which can recognize the corresponding receptors or proteins expressed on the cell surface. In this way, siRNA can be delivered specifically to the cells of interest, leading to targeted delivery, which can further improve the delivery efficiency and reduce the toxicity by avoiding non-specific interactions and at lower doses. To this end, we have developed dendrimers bearing a long PEG chain and an individual multivalent dendron. The PEG chain is to release the steric congestion between dendrimer and ligand/antibody, whereas the multivalent dendron provides a platform of a controllable conjugation for ligands. Besides, we also designed and synthesized another PEGylated dendrimers bearing a free thiol group for the preparation of antibody/dendrimer conjugates
Appelhans, Dietmar y Brigitte Voit. "Dendrimere als vielseitige, nano-skalige Objekte für biomimetische, biomedizinische und katalytische Fragestellungen". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1188377327860-73166.
Texto completoDendrimere sind aufgrund ihrer dreidimensionalen Makromolekülstruktur und -form und ihrer steuerbaren Eigenschaften sowohl an der Oberfläche als auch im Molekülinneren ideale Modellverbindungen im Nanometerbereich – sie sind zwischen 1 und 10 nm groß –, die vorzugsweise in der Medizin, Pharmazie, Biologie, Supramolekularen Chemie, Nanotechnologie und den Materialwissenschaften eingesetzt werden. Aufgrund ihrer hohen Endgruppendichte und der kompakten, stark verzweigten Molekülform werden Dendrimere unter anderem als Trägermaterialien und Transportsysteme für Wirkstoffe und Metallionen, zum Beispiel als Kontrastmittel zur Visualisierung von Organen und Blutgefäßen, als Template für metallische Nanopartikel, zur Erzeugung künstlicher Enzymfunktionen und in der Katalyse erfolgreich untersucht
Dirksen, Anouk. "Photoinduced processes in dendrimers". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/87283.
Texto completoCumpstey, Neil. "Highly branched phosphorescent dendrimers". Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433310.
Texto completoColeshill, Anita. "Synthesis of polyester dendrimers". Thesis, University of Warwick, 1998. http://wrap.warwick.ac.uk/55728/.
Texto completoDrew, Philip Morton. "Computer simulation of dendrimers". Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418245.
Texto completoOrtiz-Hernández, Wilfredo. "Energy transfer in dendrimers". [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0009300.
Texto completoJung, Jiyoung. "Preparation of flat dendrimers and polycyclic aromatic hydrocarbons connected via 1,3,5-triethynylbenzene core". Thesis, University of North Texas, 2008. https://digital.library.unt.edu/ark:/67531/metadc9768/.
Texto completoBerezhnaia, Veronika. "Synthesis and characterization of helicenes, dendrimers and molecular asterisks". Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0341.
Texto completoThe synthesis of molecular asterisks as "smart sensors" with a persulfurated benzene core and various ligands was explored. Asterisks with heteroaromatic ligands were synthesized for exploring their metal ions complexing ability. PEG dendrons were tested for increasing the water solubility of the asterisks, and to verify if PEG asterisks could encapsulate some hydrophobic molecules. The PEG dendrons were synthesized for making smart asterisks sensors, and for another purpose: the coating of silica nanoparticles to prevent their fast degradation in water. Unfortunately, this protection from degradation was ineffective, but we could make PEG asterisks to encapsulate molecules (Nile Red) toward new drug nanocarriers.The synthesis of chiral nanographenes embedding [5]- or [7]helicenes is reported. Usually [5]helicenes are configurationally labile, while higher helicene homologs are stable. We synthesized a stable chiral nanographene with six embedded [5]helicene units (a [5]helicene trimer). We found a strong distortion of benzene rings, especially in the triphenylene core. The enantiomers were separated and the chiroptical properties were measured.The synthesis of [7]helicene trimer was also performed with a great enantio- and diastereoselectivity. When a Ni(0)- mediated cyclotrimerization is achieved with an enantiopure [7]helicene substrate, only one enantiomer of the trimer is obtained, while keeping intact the configuration of the substrate. On a racemic substrate, three diastereomers were obtained. One of them demonstrated the highest values of a benzene ring distortion reported to date (mean puckering angle and twisting angle)
Qiu, Jieru. "Dendrons phosphorés fluorescents amphiphiles : synthèse, caractérisation, applications en oncologie". Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30274.
Texto completoNanotechnologies have the high potential to revolutionize various other classical technologies in many fields, due to the development of numerous nanodevice types, and have been intensively studied over the last decade. Among these nanoparticles, dendrimers and dendrons pertain to the "nano-world" by virtue of their size. Their nanometric sizes can be tailored as well, for instance, their multivalency and charges. Within the dendrimer space, phosphorus dendrimers and dendrons appear to be among the most useful dendritic systems due to the extraordinary reactivity and versatility of the phosphorus chemistry. In this thesis, we designed several families of original amphiphilic fluorescent phosphorus dendrons with interesting potential in the fields of nanomaterials and nanomedicine. Hexachlorocyclotriphosphazene used as a core was linked with five 4-hydroxybenzaldehyde and one monomer (pyrene and maleimide derivatives as fluorescent monomers and azabisdimethylphosphonate derivatives as non-fluorescent monomer). The dendrons were prepared up to generation 2 by a divergent method. The last step is the grafting of amino pyrrolidine or amino piperidine following by protonation with HCl to get the expected cationic amphiphilic fluorescent phosphorus dendrons. Their physical characterization were evaluated through numerous technics: NMR, UV, critical micelle concentration (CMC), dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM), fluorescent spectra, circular dichroism and thermogravimetry. In a next step, the biological properties of the dendrons have been examined. The cytotoxicity of dendrons was determined using MTT test and Alamar Blue assay performed on eleven cells lines including both cancer cells and healthy cells (HL-60, HCT-116, A549, MCF7, PC3, U87, K562, K562R, MCR5, MDA-MB231 and HT-29 cells line). Hemolysis assays were used to test the effect of dendrons on the cell membrane. Their ability to bind genetic material was studied by gel electrophoresis using fluorescein-labeled small interference RNA siBCL-xL. Flow cytometry method was used to study the internalization of dendriplexes into tumor cells. In order to modulate the anticancer properties of the fluorescent dendrons, carbon quantum dots (CQDs) were chosen to conjugate with the pyrene dendrons in the presence of a cytotoxic agent like doxorubicin (DOX), physically loaded into 'micelles'. [...]
Preston, Adam J. "Structural and functional relationships in dendrimers Part 1: synthesis and study of liquid crystalline dendrimers as additives to dental composites. Part 2: effect of selective metal coordination on dendrimer structure /". Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1104355003.
Texto completoTitle from first page of PDF file. Document formatted into pages; contains xxvi, 533 p.; also includes graphics (some col.) Includes bibliographical references (p. 259-292).
Javor, Sacha. "Peptide dendrimers as enzyme mimics /". [S.l.] : [s.n.], 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000277027.
Texto completoHemingway, Leon Robert. "Dendrimers for light emitting diodes". Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325840.
Texto completoMuhanna, Muhanna Kamal. "Approaches to functionalised pamam dendrimers". Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286768.
Texto completoLeire, Eva Emma Maria. "Multifunctional dendrimers for antibacterial applications". Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/36191/.
Texto completoChen, Chao. "Amphiphilic dendrimers for siRNA delivery". Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4738.
Texto completoA key challenge in RNAi-based gene therapy is the safe and effective siRNA delivery. Recently, our group has established amphiphilic dendrimers as robust and effective nonviral delivery vectors for siRNA, which combine the beneficial delivery features of both lipid and dendritic polymer vectors while overcoming their shortcomings.With the desire to understand the underlying mechanism of amphiphilic dendrimers for efficient delivery, I performed a structure/activity relationship (SAR) analysis of a series of dendrimers featuring hydrophobic tails of different lengths during my PhD thesis. We systematically investigated these dendrimers for their self-assembling characters and their capacities for both binding and delivery of siRNA. Our results demonstrate that an optimal balance between the hydrophobic alkyl chain length and the hydrophilic dendritic portion plays a crucial role in the self-assembly and the delivery activity towards siRNA.Furthermore, we developed a novel bola-amphiphilic dendrimer by combining bola-amphiphiles and our amphiphilic dendrimers and studied their self-assembly properties and the corresponding siRNA delivery efficiency. This peculiar bola-amphiphilic vector was able to respond to reactive oxygen species for specific delivery, opening a new perspective for the design of stimuli-trigged vectors for targeted siRNA delivery.Finally, I studied the “proton sponge effect” of the amphiphilic dendrimer vectors using the Langmuir monolayer film technique. Our results gave direct evidence of swelling of the amphiphilic dendrimers upon protonation, offering unambiguous experimental data to support the “proton sponge effect”
Chen, Chao. "Amphiphilic dendrimers for siRNA delivery". Electronic Thesis or Diss., Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4738.
Texto completoA key challenge in RNAi-based gene therapy is the safe and effective siRNA delivery. Recently, our group has established amphiphilic dendrimers as robust and effective nonviral delivery vectors for siRNA, which combine the beneficial delivery features of both lipid and dendritic polymer vectors while overcoming their shortcomings.With the desire to understand the underlying mechanism of amphiphilic dendrimers for efficient delivery, I performed a structure/activity relationship (SAR) analysis of a series of dendrimers featuring hydrophobic tails of different lengths during my PhD thesis. We systematically investigated these dendrimers for their self-assembling characters and their capacities for both binding and delivery of siRNA. Our results demonstrate that an optimal balance between the hydrophobic alkyl chain length and the hydrophilic dendritic portion plays a crucial role in the self-assembly and the delivery activity towards siRNA.Furthermore, we developed a novel bola-amphiphilic dendrimer by combining bola-amphiphiles and our amphiphilic dendrimers and studied their self-assembly properties and the corresponding siRNA delivery efficiency. This peculiar bola-amphiphilic vector was able to respond to reactive oxygen species for specific delivery, opening a new perspective for the design of stimuli-trigged vectors for targeted siRNA delivery.Finally, I studied the “proton sponge effect” of the amphiphilic dendrimer vectors using the Langmuir monolayer film technique. Our results gave direct evidence of swelling of the amphiphilic dendrimers upon protonation, offering unambiguous experimental data to support the “proton sponge effect”
PRINCIVAL, Iza Mirela Rodini Garcia. "Síntese de Derivado de Furano ligados em Dendrímero bis-MPA e sua atividade anticâncer". Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/17327.
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Descrevemos aqui, um estudo citotóxico comparativo utilizando uma biblioteca de compostos contendo a função furano, e o dendrímero Bis-MPA. Dos compostos furânicos testados, os que apresentaram melhor resultado citotóxico frente às células tumorais foram sintetizados em grande escala (5 g). Assim, estes compostos, puderam ser submetidos à estudos de incorporação física (por interações químicas) ou ligação química (via ligação covalente) ao dendrímero. No intuito de estudar os efeitos citotóxicos que ambos os sistemas poderiam apresentar, os testes foram realizados empregando as seguintes linhagens celulares HEP-2, HT-29, MCF-7, NCI-H292 e HL-60, correspondentes ao câncer de Carcinoma de laringe, Carcinoma de Cólon, Adenocarcinoma de Mama e Leucemia promielocítica aguda. Cada teste foi realizado em quadruplicata, utilizando os compostos com alto grau de pureza (>99%), e de um mesmo lote do material, para todos os testes de toxicidade. Os testes de citotoxicidade r com o dendrímero bis-MPA, foram realizados utilizando o composto comercial, porém com checagem de pureza via RMN antes de realizar os testes e as reações químicas. Todos os testes biológicos após serem realizados, foram analisados utilizando o método colorimétrico MTT. Em suma, este estudo levou ao preparo de compostos em escala de gramas, com alto grau de pureza, necessário para estudar a possibilidade de desenvolver novos ligantes bifuncionais, na tentativa de se construir dendrímeros polifuncionalizados, contendo moléculas que apresentaram atividade citotóxica em sua estrutura química. Esse estudo vem sendo explorado pelo grupo na tentativa de expandir essa linha de raciocínio, e tentar corroborar com estudos da literatura no que diz respeito ao mecanismo de ação, e como esses se comportam frente a células tumorais, em testes in vitro. Dentre os compostos que apresentaram boas respostas aos ensaios biológicos, dois deles merecem destaque por mostrarem-se substâncias extremamente eficazes em testes de inibição total das células. Estes compostos têm em comum um anel furano ligado diretamente a uma enona ou a um ácido acrílico (compostos 32 e 35 respectivamente).
Here we describe a comparative cytotoxic study by using a library of compounds containing a furan moiety and the dendrimer Bis-MPA. Among furan tested compounds against tumor cancer cells, those that have shown better results were synthesized in a large scale reaction (5 g). Thus, these compounds, which have shown high biological activity, underwent physical incorporation studies (for chemical interactions) or chemically linked (via covalent bond) with the dendrimer. In order to study the cytotoxic effects that could exhibit by both systems, tests were conducted using the following tumor cancer cells: HEp-2, HT-29, MCF-7 e HL60. Each test was performed in quadruplicate using the compounds in their high purity (>99%) and used as a single batch of material for all toxicity tests. The dendrimer Bis-MPA cytotoxic tests were conducted subjecting the commercial reagent although with a pre checked in its purity by NMR before do the tests and chemical reactions. All biological tests after have been done were analyzed using the MTT colorimetric method. In summary, this study has led to preparation of compounds in multi gram scale in a high purity, necessary to realize the possibility of developing new bifunctional links, in an attempt to build polifuncionalized dendrimers containing active cytotoxic active molecules in their chemical structure. This study is being explored by the group in an attempt to expand this line of reasoning, and try to corroborate with literature data regarding the mechanism of action, and their behavior against the tumor cancer cells in an in vitro tests. Among the compounds that showed good activity to biological assays, two of them are noteworthy due to their extremely effective activity in total inhibition tests of cells. These compounds have in common a furan ring attached to an enone or an acrylic acid (compounds 32 and 35 respectively).
Wang, Qi. "Synthesis of multi-functional dendrimers for targeted delivery of nucleic acids". Electronic Thesis or Diss., Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4068.
Texto completoWe have demonstrated that structurally flexible poly(amido)amine (PAMAM) dendrimers are efficient siRNA delivery system in vitro and in vivo recently. We would like to undertake further investigation on targeted siRNA delivery using dendrimers conjugated with specific ligands or antibodies, which can recognize the corresponding receptors or proteins expressed on the cell surface. In this way, siRNA can be delivered specifically to the cells of interest, leading to targeted delivery, which can further improve the delivery efficiency and reduce the toxicity by avoiding non-specific interactions and at lower doses. To this end, we have developed dendrimers bearing a long PEG chain and an individual multivalent dendron. The PEG chain is to release the steric congestion between dendrimer and ligand/antibody, whereas the multivalent dendron provides a platform of a controllable conjugation for ligands. Besides, we also designed and synthesized another PEGylated dendrimers bearing a free thiol group for the preparation of antibody/dendrimer conjugates
Kevwitch, Robert M. "Strategies for degradable dendrimers: Fragmenting o-nitrobenzyl ether dendrimers and disassembling oligomers of model dendritic systems". Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280481.
Texto completoMenot, Bérengère. "Dendrimères dérivés du glycérol : Synthèses et Applications". Thesis, Reims, 2015. http://www.theses.fr/2015REIMS044.
Texto completoSince a few years, our team is interested in developing dendrimers using different biosourced derivatives (pentoses, glycerol or derivatives) whose valuation is a prime research topic within our region. Some glyco- or glycerodendrimers derivate from PPIs (polypropylenimines) were already obtained and valued in several domains. This thesis presents the synthesis and the characterization of new glycerol-based dendrimers. Their efficiency in catalytic processes or for the encapsulation of molecules of interest was also demonstrated. First, two new families of dendrimers directly constituted of glycerol as building block, were synthesized: one via click chemistry reactions to obtain glyceroclickdendrimers, and the other, via successive reactions of allylation and oxidation to obtain glyceroladendrimers. Secondly, the functionalization of PAMAM's dendrimers with glycerol carbonate was carried out either by “classical” or microwave assisted synthesis. The efficiency of these glycerodendrimers (in comparison with PPI-based glycerodendrimers) was evaluated: firstly, for the stabilization of platinum nanoparticles used for the catalysis of hydrogenation of α,β-unsaturated ketones in aqueous media, and then, for the encapsulation of organic molecules of interest. Finally, a first molecular dynamics approach was realized to determine the structural properties of two glycerodendrimers from the coupling reaction between the glycerol carbonate and PAMAM or PPI
Bos�ko, Jaroslaw Tomasz y jbosko@unimelb edu au. "Molecular simulation of dendrimers under shear". Swinburne University of Technology. Centre for Molecular Simulation, 2005. http://adt.lib.swin.edu.au./public/adt-VSWT20050804.141034.
Texto completoNijhuis, Christian Albertus. "Redox-active dendrimers at molecular printboards". Enschede : University of Twente [Host], 2006. http://doc.utwente.nl/57611.
Texto completoGroot, Debby de. "Dendrimers as homogeneous transition metal catalysts". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/58731.
Texto completoSuek, Nicholas William. "Molecular dynamics simulations of amphiphilic dendrimers". [Ames, Iowa : Iowa State University], 2008.
Buscar texto completoPeori, M. Brad (Michael Brad). "New synthetic routes to organometallic dendrimers". Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33819.
Texto completoBarata, Teresa Silva. "Structural studies on glycosylated polyamidoamine dendrimers". Thesis, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535500.
Texto completoKing, Amy Sarah Helen. "Synthetic studies toward novel crystalline dendrimers". Thesis, University of East Anglia, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327493.
Texto completoUrdang, Zachary D. "Towards Quinone Methids Releasing Disassembling Dendrimers". Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146912.
Texto completoChen, Jiaxuan. "Amphiphilic dendrimers for nucleic acid delivery". Electronic Thesis or Diss., Aix-Marseille, 2021. http://theses.univ-amu.fr.lama.univ-amu.fr/210310_CHEN_287zgujq865yybu380ckoiv981e_TH%20(1).pdf.
Texto completoGene therapy via nucleic acid therapeutics represents the most recent advance made during the biotechnology revolution in medicine. While allowing the treatment of almost any disease with known gene sequence at its root, nucleic acid therapeutics are vulnerable to enzymatic degradation and their negative charge also presents a major obstacle for cellular uptake. Amphiphilic dendrimers are emerging as appealing non-viral vectors for nucleic acid delivery thanks to their ability to offer delivery advantages of both lipid and polymer vectors. In my PhD thesis, I designed, synthesized and characterized a series of amphiphilic dendrimers for nucleic acid delivery. These amphiphilic dendrimers bear either hydrophobic alkyl chains with varying levels of unsaturation or bola-lipid core with thioacetal group responsive to the reactive oxygen species (ROS), alongside hydrophilic PAMAM dendrons the generation number and cationic terminals (tertiary amine, arginine and guanidine functionalities) of which vary between amphiphilic dendrimers. I established a robust and reproducible synthesis for these dendrimers. Preliminary studies on the use of these dendrimers for nucleic acid delivery revealed that those with arginine and guanidine terminals showed better delivery efficiency compared to those bearing primary amine terminals. Also, performance of bola-amphiphilic dendrimers in DNA and siRNA delivery was generation-dependent. Collectively, the results provide both a proof-of-principle of the use of amphiphilic dendrimers as vectors for nucleic acid delivery, and a means to understanding the structure-activity relationship involved
Gobouri, Adil Abdullah H. "Synthesis and characterization of novel BINOL-based symmetrical and asymmetrical axially chiral dendrimers". Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-and-characterization-of-novel-binolbased-symmetrical-and-asymmetrical-axially-chiral-dendrimers(27e9cb60-7ef9-4178-9ed1-44fcfd216a65).html.
Texto completoRapakousiou, Amalia. "Ingéniérie des nanomatériaux redox métallocèniques". Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0437/document.
Texto completoDendrimers and polymers containing transition metals such as iron, cobalt andrhodium can serve in the fabrication of useful nanomaterials for catalysis, molecularrecognition and molecular electronics. For their construction, ionic bonds, clickchemistry: CuAAC and hydroamination, ROMP and radical polymerization were usedand allowed the formation of new types of metallocenyl polyélectrolytes. Thesynthesis of new gold, silver and palladium nanoparticles from these metallopolymersand metallodendrimers has been developed, leading to specific and well-definedarchitectures. These supramolecular assemblies and molecular engineering opensthe way towards the application of organometallic chemistry in the design of newstructured nanoparticle-containing nanomaterials using the redox properties ofmetallomacromolecules
Johansson, Emma M. V. "Combinatorial discovery of glycopeptide dendrimers targeting lectins /". [S.l.] : [s.n.], 2009. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Texto completoBhattacharya, Papri. "A Novel Series of Viologen-Containing Dendrimers". Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_theses/134.
Texto completoNyström, Andreas. "Dendrimers and dendronized polymers : synthesis and characterization". Doctoral thesis, KTH, Fiber- och polymerteknik, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3970.
Texto completoQC 20100914
Villavicencio, Ovette. "STUDIES OF MULTI-PHOTOCHROMIC LIQUID CRYSTALLINE DENDRIMERS". Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1245%5F1%5Fm.pdf&type=application/pdf.
Texto completoNyström, Andreas. "Dendrimers and dendronized polymers : synthesis and characterization /". Stockholm, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3970.
Texto completoGardiner, Jonathan P. D. "Delivery of antibacterial triclosan by PAMAM dendrimers". Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505414.
Texto completoStoddart, Alison. "Synthesis, characterisation and properties of novel dendrimers". Thesis, Durham University, 2002. http://etheses.dur.ac.uk/4153/.
Texto completoHalim, Mounir. "Light-emission from conjugated dendrimers and polymers". Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4297/.
Texto completoSimpson, Stephen Charles. "Computer simulations of Fréchet dendrimers in solutions". Doctoral thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/6363.
Texto completoThe structure and dynamics of dendrimers in solution are studied through nanosecond atomistic Molecular Dynamics (MD) simulations of explicitly solvated Fréchet dendrimers, generations G1 to G5. The properties of these dendrimers are investigated in four solvent invironments: vacuum and water (representatives of poor solvents), and tetrahydrofuran (THF) and chloroform (representatives of good solvents). To establish the quality of the solvent on the conformation of the dendrimer, additional nanosecond MD simulations fo the dendrimers are performed, from both inititally folded and unfolded conformations.
Takeda, Shigeo. "Functionalization of Glucan Dendrimers and Bio-applications". Kyoto University, 2020. http://hdl.handle.net/2433/253505.
Texto completoYamaguchi, Nori. "Supramolecular Assemblies: Dendrimers, Linear Arrays, and Polypseudorotaxanes". Diss., Virginia Tech, 1999. http://hdl.handle.net/10919/28741.
Texto completoPh. D.