Literatura académica sobre el tema "Cytologie – urine"
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Artículos de revistas sobre el tema "Cytologie – urine"
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Lau, Paul, Joseph L. Chin, Stephen Pautler, Hassan Razvi y Jonathan I. Izawa. "NMP22 is predictive of recurrence in high-risk superficial bladder cancer patients". Canadian Urological Association Journal 3, n.º 6 (1 de mayo de 2013): 454. http://dx.doi.org/10.5489/cuaj.1173.
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Introduction: The nuclear matrix protein 22 (NMP22) assay hasbeen shown to have greater sensitivity for the diagnosis and detectionof recurrent urothelial carcinoma of the bladder (UCB) overthat of traditional urine cytology. We assessed the use of NMP22to predict which high-risk superficial UCB patients will have recurrence,progression or disease-related death; we compared theseresults to standard urine cytology.Methods: One hundred consecutive patients with high-risk superficialUCB were enrolled. During surveillance, urine was collectedfor cytology and NMP22 testing. Patients were followed for atleast 6 months. Retrospective chart review was undertaken to collectdata on previous tumour history, tumour characteristics, diseaserecurrences, progression and death. Kaplan-Meier analyseswere performed to determine the significance between NMP22-positive and -negative patients in terms of recurrence-free, progression-free and overall survival. Similar analyses were performedfor urine cytology.Results: From 94 eligible patients, 15 and 79 were NMP22 positiveand negative, respectively. The baseline characteristics betweenthe 2 groups were not significantly different in terms of patientcharacteristics, prior tumour history or intravesical therapiesreceived. Mean recurrence-free survival time was significantlylower in the NMP22 positive group (p = 0.038); however, meanprogression-free and overall survival were not significantly differentbetween the 2 groups (p = 0.297 and 0.519, respectively).Urine cytology demonstrated no significant predictive power fordisease recurrence, progression or survival.Conclusion: The nuclear matrix protein 22 assay appears to havepredictive value for future tumour recurrences, but not progressionor overall survival in patients with high-risk superficial UCB.Introduction : Il a été montré que le test de dépistage de la protéine22 de la matrice nucléaire (NMP22) présentait une sensibi -lité supérieure pour le diagnostic et le dépistage du carcinomeurothélial récurrent de la vessie, en comparaison avec la cytologieurinaire classique. Nous avons évalué l’emploi de la NMP22pour prédire la récurrence, la progression de la maladie et le décèsrelié à la maladie chez des patients atteints de carcinome urothélialde la vessie (CUV) superficiel et présentant un risque élevé. Lesrésultats ont été comparés à ceux obtenus avec une épreuve decytologie urinaire standard.Méthodologie : Cent patients consécutifs présentant un CUV superficielà risque élevé ont été inscrits à l’étude. Pendant la périodede surveillance, un échantillon d’urine a été recueilli en vue del’épreuve de cytologie et du test de dépistage de la NMP22. Lesuivi a duré au moins 6 mois. Un examen rétrospectif des dossiersa fourni des données concernant les antécédents tumoraux, lescaractéristiques de la tumeur, les récurrences, la progression etles décès. Des analyses de Kaplan-Meier ont été effectuées afinde déterminer le niveau de signification entre les patients NMP22-positifs et négatifs en matière de délai sans récurrence, de délaisans progression et de survie globale. Des analyses similaires ontété réalisées pour les données obtenues par cytologie urinaire.Résultats : Sur les 94 patients admissibles, 15 patients étaientNMP22-positifs et 79, NMP22-négatifs. Les caractéristiques audépart entre les deux groupes n’étaient pas significativement différentesen ce qui concerne les caractéristiques des patients, lesantécédents tumoraux et les antécédents de traitements intravésicaux.Le délai moyen de survie sans récurrence était significativementmoins long dans le groupe de patients NMP22-positifs(p = 0,038); cela dit, le délai moyen sans progression et la survieglobale moyenne n’étaient pas significativement différents entreles deux groupes (p = 0,297 et 0,519, respectivement). L’épreuvede cytologie urinaire n’a montré aucune puissance de prédictionsignificative concernant la récurrence de la maladie, la progressionou la survie.Conclusion : Le test de dépistage de la protéine 22 de la matricenucléaire semble avoir une certaine valeur prédictive concernantles récurrences tumorales, mais non la progression ou la survieglobale chez les patients atteints de CUV superficiel présentantun risque élevé de récurrence.
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Pitra, Tomáš, Marie Dikanová, Milan Hora, Michal Michal, Ondřej Hes y Kristýna Pivovarčíková. "Correlation of invasive methods and urine cytology in detection of urothelial neoplasms: one centre early experience with application of The Paris System for Reporting Urinary Cytology". Czech Urology 22, n.º 4 (1 de diciembre de 2018): 275–84. https://doi.org/10.48095/cccu2018042.
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Tatomirovic, Zeljka, Radojka Bokun, Ljljana Ignjatovic, Anastasija Aleksic, Vesna Skuletic y Jovan Dimitrijevic. "The significance of cytologic examination of urine in the diagnosis of renal allograft dysfunction". Vojnosanitetski pregled 60, n.º 3 (2003): 299–304. http://dx.doi.org/10.2298/vsp0303299t.
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Background. This paper presents our experience with cytologic examination of urine in diagnosing renal allograft dysfunction. Methods. The study group included 23 patients with renal allograft dysfunction, selected from 56 patients who underwent renal transplantation. Etiologic diagnosis was made according to the clinical picture, histological findings during allograft biopsy, and cytologic examination of urine. Urine sediment was obtained in cytocentrifuge and was air dried and stained with May Grunwald Giemsa. Results. Out of 23 patients with allograft dysfunction in 18 (78.3%) patient it was caused by acute rejection, and in 5 (8.9%) patients by allograft infarction, cyclosporine nephrotoxicity, acute tubular necrosis and chronic nephropathy. In eighteen patients (78.3%) cytologic examination of urine was pathologic, while in 16 (70%) clinical and histology findings coincided with urine cytology findings. Out of 18 patients with acute allograft rejection in 15 patients cytologic examination of urine coincided with acute rejection. Out of 7 patients with expressed cyclosporine nephrotoxicity, in 5 cytologic examination of urine confirmed the cause of allograft dysfunction, as well as in one of 2 patients with acute tubular necrosis. Cytologic examination of urine indicated parenchymal damage in 2 patients with reccurent disease (membranoproliferative and focal sclerosing glomerulonephritis). In 4 of 5 patients suffering from chronic rejection in a year?s monitoring period, urine sediment periodically consisted of lymphocytes, neutrophilic leucocytes, monocyte/macrophages, tubular cells and cilindres, without the predominance of any cell type. In 3 patients allograft dysfunction was caused by infective agents (bacteria, fungus cytomegalovirus). Conclusion. Cytologic examination of urine might be an alternative to histological in diagnosing acute allograft rejection and acute tubular necrosis or nephtotoxicity. Also it might indicate parenchymal disease while the importance of urine cytology in chronic allograft nephropathy needs to be investigated further.
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Astvatsaturyan, Kristine, David Frishberg y Arsen Ramazyan. "Cytology of the Urinary Tract: Specimen Sampling, Preparation, Adequacy, and Normal Cellular Components". CMAS Journal 1 (17 de abril de 2024): 2. http://dx.doi.org/10.25259/cmasj_04_01.
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Urine evaluation is one of the oldest tests used in ancient medicine. Cytologic examination of urine is a simple, non-invasive, cost effective, and reliable method to uncover a wide variety of reactive and neoplastic processes in urothelium. Urinary tract lesions are often multifocal, may be inapparent on cystoscopic examination or inaccessible to directly biopsy. Thus, urine cytology remains one of the most common methods for the initial diagnosis of urothelial carcinoma that may be manageable with early detection. In this article we review indications for urine cytology, sampling techniques, preparatory methods, adequacy, and elements of normal urine.
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Longo, Thomas Andrew, Ajay Gopalakrishna, Joseph J. Fantony y Brant Allen Inman. "Your opinion counts: How do you treat atypical/suspicious cytology?" Journal of Clinical Oncology 34, n.º 2_suppl (10 de enero de 2016): 463. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.463.
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463 Background: Urine cytology has often been reported as a highly specific but poorly sensitive test. Cytology is reported as positive, negative, atypical, or suspicious. Atypical/suspicious cytologies account for roughly a quarter of the results and present a clinical dilemma. Physicians’ risk aversion means they are typically treated as positive and result in clinical action. We test the effects of this assumption on sensitivity and specificity. Methods: After IRB approval, we queried clinical and pathology databases to identify all subjects at Duke University Medical Center who had undergone both a urine cytology and a cystoscopy from 1/2003 to 1/2012. Diagnostic test performance metrics were calculated using logistic models: (a) a generalized estimating equation (GEE) and (b) a generalized linear mixed model (GLMM). These take into account clustered/correlated test results that occur due to repeated testing within subjects. Results: A total of 990 unique subjects were identified that provided 4,733 pairs of cytology and cystoscopy for analysis. Our cohort was 61% male, 75% Caucasian, and had 54% current or former smokers. Of cytologies, 1898 (40%) were negative, 423 (9%) positive, and 2408 (51%) suspicious or atypical. When suspicious/atypical cytology results using the GLMM model were classified as positive, the specificity was 62% [95%CI: 58-66%] and the sensitivity was 41% [95% CI: 38-44%]. When these results were re-classified as negative, this had the effect of a large increase in specificity 100% [95%CI: 100-100%] with a consequent decrease in sensitivity 0% [95%CI: 0-2%]. Conclusions: In our study, the performance of urine cytology depended heavily on how the equivocal (atypical/suspicious) results were classified and dealt with. Our sensitivity was maximized when equivocal cytologies were considered positive, but at significant detriment of the specificity. Contrarily, our specificity improved greatly when the equivocal results were considered negative, but at the expense of a poor sensitivity. Furthermore, the diagnosis of an atypical/suspicious cytology was higher at our medical center than reported in the literature, and therefore significantly overestimated the performance of the urine cytology test.
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Barkan, Güliz A., Eva M. Wojcik, Ritu Nayar, Spasenija Savic-Prince, Marcus L. Quek, Daniel F. I. Kurtycz y Dorothy L. Rosenthal. "The Paris System for Reporting Urinary Cytology: The Quest to Develop a Standardized Terminology". Acta Cytologica 60, n.º 3 (2016): 185–97. http://dx.doi.org/10.1159/000446270.
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The main purpose of urine cytology is to detect high-grade urothelial carcinoma (HGUC). With this principle in mind, The Paris System (TPS) Working Group, composed of cytopathologists, surgical pathologists, and urologists, has proposed and published a standardized reporting system that includes specific diagnostic categories and cytomorphologic criteria for the reliable diagnosis of HGUC. This paper outlines the essential elements of TPS and the process that led to the formation and rationale of the reporting system. The Paris System Working Group, organized at the 2013 International Congress of Cytology, conceived a standardized platform on which to base cytologic interpretation of urine samples. The widespread dissemination of this approach to cytologic examination and reporting of urologic samples and the scheme's universal acceptance by pathologists and urologists is critical for its success. For urologists, understanding the diagnostic criteria, their clinical implications, and the limitations of TPS is essential if they are to utilize urine cytology and noninvasive ancillary tests in a thoughtful and practical manner. This is the first international/inclusive attempt at standardizing urinary cytology. The success of TPS will depend on the pathology and urology communities working collectively to improve this seminal paradigm shift, and optimize the impact on patient care.
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Sharma, Anurag, Shivani Sharma, Niharika Patnaik, Dinesh Pradhan, Kaliprasad Satapathy, Manas R. Pradhan y Sambit K. Mohanty. "Cytomorphologic and Immunophenotypic Profile of a Cohort of Small Cell Carcinoma of the Urinary Bladder". Acta Cytologica 60, n.º 5 (2016): 475–80. http://dx.doi.org/10.1159/000449399.
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Background: The incidence of primary small cell carcinoma (SCC) of the urinary bladder is extremely rare. We sought to analyze the cytologic and immunophenotypic features of SCC of the urinary bladder in urine and reassert the importance of cytologic examination of urine specimens for diagnosis of this tumor. Methods: We studied the clinical and cytomorphologic features in the presurgical urine specimens (4 voided urine and 2 bladder-washing specimens) of histopathologically and immunohistochemically proven cases of SCC of the urinary bladder. Results: There were 6 cases, all males, with an age range of 61-81 years. On cytologic and histopathologic examination, typical SCC morphology was present in all cases. On immunohistochemistry, synaptophysin and CD56 were positive in all 6 cases, while chromogranin was positive in only 3. The Ki-67 labeling index ranged from 30 to 100%. Conclusions: SCC should be kept in the differential diagnosis, when high-grade urothelial carcinoma is suspected in a urine cytology specimen, as this distinction has important therapeutic and prognostic implications. Therefore, a careful observation and, if required, the use of an appropriate immunocytochemical panel on the presurgical urine specimens can lead to a correct diagnosis.
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Boccafoschi, C., F. Montefiore, S. Treffiletti, D. Signorello y A. Langé. "Preliminary comparative considerations about urinary cytology and the Bard BTA test in the diagnosis and follow-up of superficial bladder cancer". Urologia Journal 62, n.º 1_suppl (enero de 1995): 88–90. http://dx.doi.org/10.1177/039156039506201s23.
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— The value of urinary cytology in the diagnosis and follow-up of superficial transitional cell carcinoma of the bladder is well known. Results of traditional cytologic examinations may be affected by the different methods of urine collection, preservation, manipulation and observation of the samples so that more objective tools are desirable. The aim of this study in to compare the traditional cytologic examinations with a new diagnostic in-vitro test (Bard BTA test), which can detect antigen complexes in the urine due to the contact of the tumour cells with the basement membrane. The Bard BTA test is a latex agglutination assay which identifies the bladder tumour antigens in the urine. The result of the agglutination reaction (positive or negative) may be visually distinguished by the variation in colour of special strips of testing paper. The Authors report on a preliminary experience in the follow-up of patients with previous superficial transitional cell carcinoma of the bladder: they compare the results of traditional cytology, the Bard BTA test and cystoscopy and have found agreement in 70% of the cases.
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Umar, Ahmed M., Uzodimma E. Onwuasoanya, Emmanuel U. Oyibo, Adamu Dahiru y Ismaila A. Mungadi. "The pattern of urine cytology among patients with clinical diagnosis of bladder tumor in a tertiary hospital northwest Nigeria". International Surgery Journal 6, n.º 10 (26 de septiembre de 2019): 3521. http://dx.doi.org/10.18203/2349-2902.isj20194402.
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Background: Urine cytology is a simple, safe, non-invasive and cheap investigation that is used as adjunct to cystoscopy in the diagnosis of bladder cancer. Its low sensitivity is a major limitation against its use as a sole diagnostic test for bladder cancer. The objective of this study was to determine the pattern of urine cytology seen in patients with clinical diagnosis of bladder tumour in our practice.Methods: This is a retrospective study of patients with clinical diagnosis of bladder tumour that had urine cytology in our centre. The age and gender of the patients, number of urine cytology per patient per year and cytologic diagnosis were analysed using the SPSS 20.Results: During the period under review, a total of 512 urine cytology was done for patients with clinical diagnosis of bladder tumour. The age range of the patients was 6 to 90 years with modal age of 60 years. 457 (89.3%) were males while 54 (10.5%) were females and 1 (0.2%) was unspecified. Male to female ratio was 8.5:1. The highest number of urine cytology was done in 2013 with 64 (12.5%) while the least number was 1 (0.2%) recorded in 2001 and 2003. Only 68 (13.3%) specimens were reported to be malignant while 245 (47.9%) were reported as negative representing the most common cytological diagnosis in the study.Conclusions: Although urine cytology is useful in the diagnostic workup of patients with bladder mass, it is unlikely it would supplant cystoscopy and biopsy in the diagnosis of bladder cancer.
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Mendoza, R. P., T. Haidary y R. Gupta. "Paris System Has A Higher Cytohistologic Correlation And Reproducibility Than Traditional Urine Cytology Method". American Journal of Clinical Pathology 154, Supplement_1 (octubre de 2020): S94. http://dx.doi.org/10.1093/ajcp/aqaa161.206.
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Abstract Introduction/Objective The major limitation of urine cytology is the lack of consensus regarding the terminology and diagnostic criteria that should be used for urothelial atypia. The main goal of the newly proposed Paris System for Reporting Urine Cytology is to concentrate primarily on the detection of high grade urothelial carcinoma while minimizing the detection of low grade lesions. This study aimed to apply the criteria and categories of the Paris system in retrospectively collected urine cytology specimens and assess histologic correlation and reproducibility. Methods Two senior pathologists independently reviewed retrospectively collected urine cytology specimens strictly following the Paris system criteria for categorization. Cytologic diagnosis were compared with previous cytology result and histologic diagnosis. Results A total of 67 patients were included in the study. The mean age is 65.8 years (36-89 years), majority were males (73.1%) and African American (89.6%). Urine cytology using traditional method showed mostly atypical results (58.2%), followed by reactive (26.9%), high-grade urothelial carcinoma (11.9%) and suspicious (3.0%). On the other hand, the Paris system had more negative results (62.7%), followed by atypical (19.4%), high-grade urothelial carcinoma (11.9%) and lastly suspicious (6.0%). All of negative cases (18 out of 18) and majority of HGUC cases (7 out of 8) were concordant between the two cytology methods. Traditional urine cytology method only yielded 71.4% histologic concordance, while 100% Paris system results were concordant with bladder histology. Majority of the atypical cases using traditional method were converted to negative, and a few atypical cases were converted to suspicious and high-grade. All results using Paris system were concordant between two general pathologists. Conclusion Using the Paris system in analyzing urine cytology resulted to higher cytohistologic concordance than traditional method. Majority of atypical cases from traditional method were converted to more definitive categories. The cytopathologic analyses from two general pathologists applying the criteria of Paris system had superior reproducibility. Applying the Paris system, therefore, can significantly improve the performance of urine cytopathology.
Tesis sobre el tema "Cytologie – urine"
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Collin-Chavagnac, Delphine. "Carcinomes urothéliaux de la vessie : apport de l’analyse dans les cellules du culot urinaire de huit marqueurs microsatellites et de l’hyperméthylation de promoteurs de cinq gènes suppresseurs de tumeur". Thesis, Lyon 1, 2009. http://www.theses.fr/2009LYO10307.
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Sur la seule base de critères cliniques et anatomopathologiques, l’évolution des tumeurs superficielles de la vessie (TSV) est imprévisible. Aucun marqueur ne permet, à ce jour, l’identification des tumeurs à fort potentiel de récidive et d’évolution vers des formes agressives. Dans une première partie, nous avons étudié, chez 127 patients, le polymorphisme des microsatellites dans les cellules urinaires pour la mise en évidence de pertes d'hétérozygotie (LOH, Loss Of Heterozygosity) et 2- en tant que marqueur de suivi. Les résultats ont été comparés à la cytologie urinaire : la sensibilité des LOH est nettement supérieure à celle de la cytologie dans les TSV. La présence de LOH au niveau de TP53 et des marqueurs du chromosome 9p est associée à un risque accru de récidive. Parmi les patients ayant récidivé, l’étude des LOH était positive dans 78% des prélèvements urinaires. Dans 20% des cas, les LOH se sont positivées avant la récidive visible à la cystoscopie. Dans une deuxième partie, nous avons développé une technique urinaire quantitative rapide pour l’étude des profils de méthylation de promoteur de 5 gènes suppresseurs de tumeur. Les résultats prometteurs (sensibilité=62%) de la qPCR-HRM sont corrélés à la technique de référence et pourraient être améliorés en élargissant le panel de gènes étudiés. L’analyse des altérations génétiques et épigénétiques améliore la compréhension des mécanismes de la carcinogenèse dans les carcinomes urothéliaux. Ces altérations pourraient être utilisées comme marqueurs diagnostiques et pronostiques. La biologie moléculaire pourrait trouver toute sa place dans la prise en charge de cette pathologieOn the basis of clinical and pathological criteria, the evolution of superficial bladder tumours (SBT) is unpredictable. Currently, no marker exists permitting the identification of tumours with high potential for recurrence and progression to more aggressive forms. Firstly, we looked for loss of heterozygosity (LOH) at microsatellite polymorphisms in the bladder cells of 127 patients, with the aim of identifying a marker potentially useful in 1) diagnosis and prognosis and 2) the monitoring of patients following trans-urethral resection. Compared to urine cytology, the sensitivity of LOH detection was significantly higher for SBT. The presence of LOH at TP53 and markers of chromosome 9p was associated with an increased risk of recurrence. Among the patients who relapsed, results of LOH analysis were positive in 78% of urine samples, 20% of which were positive before the relapse was detected by cystoscopy. Secondly, we developed a technique for the rapid and quantitative urinary analysis of patterns of promoter methylation of 5 tumour suppressor genes. The promising results (sensitivity of 62%) of the qPCR-HRM correlate well with the gold standard and could be improved by expanding the panel of genes studied. Analysis of genetic and epigenetic alterations improves the understanding of mechanisms of carcinogenesis in urothelial carcinomas. These alterations could be used as diagnostic and prognostic markers. Molecular biology could therefore prove useful in the management of this pathology
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Oudahmane, Imane. "Évaluation de l’analyse vibrationnelle des urines comme potentiel outil diagnostique du cancer de la vessie". Electronic Thesis or Diss., Reims, 2024. http://www.theses.fr/2024REIMS049.
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Le diagnostic initial et la surveillance du cancer de la vessie reposent essentiellement sur la cystoscopie, un examen invasif, combinée à une cytologie urinaire dont la sensibilité est faible pour les stades précoces de ce cancer. La recherche de biomarqueurs à partir de l'urine répond au besoin de mettre au point des tests non invasifs, avec une sensibilité améliorée par rapport à la pratique actuelle. Malgré de nombreux développements, aucun test urinaire n'est actuellement recommandé pour une utilisation en routine clinique, pour des raisons de complexité d’utilisation, de performances ou de coût. L’analyse vibrationnelle des urines, par spectroscopie d’absorption infrarouge, est une approche intéressante pour la mise en place d’un test urinaire simple d’utilisation, relativement peu couteux et applicable en pratique clinique. Dans ce travail de thèse, les performances diagnostiques de cette technique, combinée à des outils d’apprentissage automatique, ont été évaluées à partir de prélèvements urinaires provenant de patients consultant dans le service d'Urologie du CHU de Reims. Malgré la forte variabilité spectrale des échantillons d'urine, l'optimisation combinée des prétraitements spectraux et des paramètres propres aux modèles de classification permet d'obtenir des résultats encourageants. Les développements algorithmiques ont été conçus pour pourvoir prendre en compte les données cliniques ; ce qui pourrait constituer une voie potentielle d'amélioration dans le cadre de futures investigationsInitial diagnosis and monitoring of bladder cancer is mainly based on cystoscopy, an invasive examination combined with urine cytology, which has limited sensitivity, especially in the early stages of this cancer. The need for non-invasive tests with improved sensitivity has led to the exploration of urine-based biomarker testing. Despite numerous advancements, no urine-based test is currently recommended for routine clinical use due to the complexity of use, performance, or cost. Vibrational analysis of urine using infrared absorption spectroscopy is an interesting approach for developing an easy-to-use, relatively inexpensive, and clinically applicable urine test. In this thesis, the diagnostic performances of this technique, combined with machine learning tools, were evaluated using urine samples from patients consulting the Urology Department of the Reims University Hospital. Despite the high spectral variability of urine samples, the combined optimization of spectral pretreatments and classification model parameters yielded promising results. Meanwhile, algorithmic developments have been developed to include clinical data, offering a way to improve the performance of these techniques in future investigations
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Hakenberg, Oliver W., P. Franke, Michael Fröhner, Andreas Manseck y Manfred Wirth. "The Value of Conventional Urine Cytology in the Diagnosis of Residual Tumour after Transurethral Resection of Bladder Carcinomas". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135153.
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Background: Transurethral resection leads to characteristic histological changes of tissue repair (’TUR cystitis‘), which also cause non-specific cytological changes. The aim of this study was to investigate the diagnostic sensitivity and specificity of conventional exfoliative urinary cytology in diagnosing residual urothelial carcinoma after differential transurethral resection. Patients and Methods: 417 urinary cytology specimens of all 374 patients undergoing primary (n = 326) or secondary (n = 91) transurethral resection of urothelial carcinoma of the bladder at our institution between June 1996 and December 1997 were examined. The cytology specimens were stained according to Papanicolaou’s method. The sensitivity and specificity of the cytologic diagnosis and of the tumour grading were compared with histological findings. Results: The overall sensitivity of urine cytology in tumour detection was 77.6% for primary lesions and 74.5% in the detection of residual carcinoma after transurethral resection. The diagnostic specificity was 77% and 84.3% respectively. The degree of sensitivity was dependent on tumour grade and was lower for well differentiated tumours. After transurethral resection, the sensitivity for grade 1 residual tumours was 11%, whereas it was 54% for grade 1 tumours before primary transurethral resection. Conclusions: The inflammatory changes following transurethral resection of primary bladder carcinoma cause reactive cytologic changes that make the diagnosis of well differentiated residual carcinoma more difficult. However, urinary cytology after transurethral resection has the same diagnostic accuracy for medium and poorly differentiated tumours as before primary resection and thus remains a very useful diagnostic toolHintergrund: Transurethrale Resektionen von Blasentumoren führen zu histologischen Veränderungen («TUR Zystitis») im Sinne regenerativer Veränderungen, welche urinzytologisch zu diagnostischen Fehleinschätzungen führen können. Das Ziel unserer Untersuchung war der Vergleich der diagnostischen Sensitivität und Spezifität der Urinzytologie vor transurethraler Resektion mit der bei der Diagnose von Residualtumoren nach transurethraler Resektion. Patienten und Methoden: Untersucht wurden 417 urinzytologische Präparate von allen 374 Patienten, die in unserer Einrichtung zwischen Juni 1996 und Dezember 1997 einer primären (n = 326) oder sekundären (n = 91) transurethralen Resektion von Urothelkarzinomen der Harnblase unterzogen wurden. Die zytologischen Präparate wurden nach Papanicolaou gefärbt. Sensitivität und Spezifität der zytologischen Diagnostik und des Tumorgradings wurden mit den histologischen Befunden verglichen. Ergebnisse: Die Sensitivität der Urinzytologie in der primären Tumorerkennung lag bei 77,6% und die für die Diagnose von Residualtumoren nach transurethraler Resektion bei 74,5%. Die diagnostische Spezifität lag bei 77% bzw. 84,3%. Die Sensitivität war abhängig vom Differenzierungsgrad der Urothelkarzinome und war bei gut differenzierten Tumoren am niedrigsten. Nach transurethraler Resektion betrug die Sensitivität der zytologischen Diagnose für G1-Residualtumore lediglich 11%, während sie für G1-Primärtumore bei 54% lag. Schlußfolgerungen: Die entzündlichenVeränderungen nach transurethraler Resektion verursachen Veränderungen exfoliierter Urothelzellen, welche die zytologische Diagnose von residualen G1-Tumoren erschweren. Die Diagnose mäßig und schlecht differenzierter residualer Urothelkarzinome nach transurethraler Resektion hat dagegen die gleiche Sensitivität und Spezifität wie die bei primärer Untersuchung, so daß die Urinzytologie auch bei der Diagnose von Residualtumoren ein wertvolles diagnostisches Verfahren darstellt
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
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Hakenberg, Oliver W., P. Franke, Michael Fröhner, Andreas Manseck y Manfred Wirth. "The Value of Conventional Urine Cytology in the Diagnosis of Residual Tumour after Transurethral Resection of Bladder Carcinomas". Karger, 2000. https://tud.qucosa.de/id/qucosa%3A27624.
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Background: Transurethral resection leads to characteristic histological changes of tissue repair (’TUR cystitis‘), which also cause non-specific cytological changes. The aim of this study was to investigate the diagnostic sensitivity and specificity of conventional exfoliative urinary cytology in diagnosing residual urothelial carcinoma after differential transurethral resection. Patients and Methods: 417 urinary cytology specimens of all 374 patients undergoing primary (n = 326) or secondary (n = 91) transurethral resection of urothelial carcinoma of the bladder at our institution between June 1996 and December 1997 were examined. The cytology specimens were stained according to Papanicolaou’s method. The sensitivity and specificity of the cytologic diagnosis and of the tumour grading were compared with histological findings. Results: The overall sensitivity of urine cytology in tumour detection was 77.6% for primary lesions and 74.5% in the detection of residual carcinoma after transurethral resection. The diagnostic specificity was 77% and 84.3% respectively. The degree of sensitivity was dependent on tumour grade and was lower for well differentiated tumours. After transurethral resection, the sensitivity for grade 1 residual tumours was 11%, whereas it was 54% for grade 1 tumours before primary transurethral resection. Conclusions: The inflammatory changes following transurethral resection of primary bladder carcinoma cause reactive cytologic changes that make the diagnosis of well differentiated residual carcinoma more difficult. However, urinary cytology after transurethral resection has the same diagnostic accuracy for medium and poorly differentiated tumours as before primary resection and thus remains a very useful diagnostic tool.Hintergrund: Transurethrale Resektionen von Blasentumoren führen zu histologischen Veränderungen («TUR Zystitis») im Sinne regenerativer Veränderungen, welche urinzytologisch zu diagnostischen Fehleinschätzungen führen können. Das Ziel unserer Untersuchung war der Vergleich der diagnostischen Sensitivität und Spezifität der Urinzytologie vor transurethraler Resektion mit der bei der Diagnose von Residualtumoren nach transurethraler Resektion. Patienten und Methoden: Untersucht wurden 417 urinzytologische Präparate von allen 374 Patienten, die in unserer Einrichtung zwischen Juni 1996 und Dezember 1997 einer primären (n = 326) oder sekundären (n = 91) transurethralen Resektion von Urothelkarzinomen der Harnblase unterzogen wurden. Die zytologischen Präparate wurden nach Papanicolaou gefärbt. Sensitivität und Spezifität der zytologischen Diagnostik und des Tumorgradings wurden mit den histologischen Befunden verglichen. Ergebnisse: Die Sensitivität der Urinzytologie in der primären Tumorerkennung lag bei 77,6% und die für die Diagnose von Residualtumoren nach transurethraler Resektion bei 74,5%. Die diagnostische Spezifität lag bei 77% bzw. 84,3%. Die Sensitivität war abhängig vom Differenzierungsgrad der Urothelkarzinome und war bei gut differenzierten Tumoren am niedrigsten. Nach transurethraler Resektion betrug die Sensitivität der zytologischen Diagnose für G1-Residualtumore lediglich 11%, während sie für G1-Primärtumore bei 54% lag. Schlußfolgerungen: Die entzündlichenVeränderungen nach transurethraler Resektion verursachen Veränderungen exfoliierter Urothelzellen, welche die zytologische Diagnose von residualen G1-Tumoren erschweren. Die Diagnose mäßig und schlecht differenzierter residualer Urothelkarzinome nach transurethraler Resektion hat dagegen die gleiche Sensitivität und Spezifität wie die bei primärer Untersuchung, so daß die Urinzytologie auch bei der Diagnose von Residualtumoren ein wertvolles diagnostisches Verfahren darstellt.
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
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Maia, TÃnia Maria Cavalcante. "Estudo citolÃgico em urina de pacientes transplantados renais para pesquisa do poliomavirus humano tipo BKV". Universidade Federal do CearÃ, 2008. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2516.
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nÃo hÃO poliomavirus tipo BK tem sido associado à nefropatia nos pacientes transplantados renais com uma incidÃncia variando entre 3 - 4% e em 60% dos casos podendo levar à perda do enxerto. Diversos estudos tÃm demonstrado a importÃncia do achado da cÃlula decoy na urina destes pacientes como primeira triagem para a replicaÃÃo viral fazendo o diagnÃstico diferencial entre a rejeiÃÃo celular aguda e a nefropatia pelo BK vÃrus. Neste contexto, o presente estudo objetivou detectar a presenÃa do BKV atravÃs da observaÃÃo da cÃlula decoy na urina dos transplantados renais, correlacionando este achado com os nÃveis sÃricos de urÃia e creatinina e o aspecto histopatolÃgico atravÃs da biÃpsia renal. Para tanto, a urina de 50 pacientes transplantados renais (28 homens e 22 mulheres) atendidos em dois hospitais de Fortaleza (Hospital UniversitÃrio Walter CantÃdio e Hospital Geral de Fortaleza) foram analisadas quanto à presenÃa de cÃlulas decoy detectadas atravÃs da citologia urinÃria pela coloraÃÃo de Papanicolau. As citologias foram analisadas e classificadas em negativa e positiva (≥ 1 cÃlula decoy). Resultado: Das 50 citologias urinÃrias analisadas 28 pacientes eram do sexo masculino e 22 do sexo feminino, receptores de doador vivo (n = 43) ou cadavÃrico (n = 7) com positividade para cÃlula decoy de 24% (12 pacientes). NÃveis de creatinina e urÃia aumentados, isoladamente, nÃo foram Ãteis para suspeitar da nefropatia pelo BKV ou rejeiÃÃo do transplante (p > 0,05). A correlaÃÃo dos nÃveis alterados de urÃia e creatinina, com a presenÃa ou ausÃncia das cÃlulas decoy, foi estatisticamente significativa (p < 0,05). A biÃpsia revelou nefropatia pelo BKV em cinco (20%) dos pacientes com cÃlulas decoy na urina e os achados histolÃgicos mais freqÃentes foram fibrose e infiltrado inflamatÃrio mononuclear. A imunossupressÃo mais empregada nos pacientes em estudo foi o esquema 1 (50%) (ciclosporina / azatioprina / zenapx), seguidos por esquemas 2 (16%) (MMF/FK 506 / zanapax) 1 esquema 3 (16%) (ciclosporina / prednizona / azatioprina). ConclusÃo: A positividade para cÃlulas decoy neste estudo (24%) à coincidente com a literatura (8 -26%) sugerindo infecÃÃo ativa. A presenÃa das cÃlulas decoy na urina foi Ãtil para definir os grupos de pacientes com possÃvel nefropatia pelo BKV daqueles com nefropatia por rejeiÃÃo, pois a negatividade para cÃlulas decoy na urina afasta em 100% dos casos a nefropatia pelo BKV, e a sua presenÃa serve de guia para avanÃar na investigaÃÃo de nefropatia pelo BKV. A biÃpsia confirmou em 5 dos 12 casos com cÃlulas decoy positivas na urina (20%) a nefropatia pelo poliomavirus sendo que um deles veio a perder o enxerto. O esquema de imunossupressÃo utilizado pelos pacientes em estudo e a presenÃa de nefropatia pelo BKV nÃo foi o que mais se relaciona na literatura. TambÃm os pacientes com nefropatia pelo BKV que utilizaram esquemas menos associados a esta condiÃÃo tiveram evoluÃÃo pior. Estes Ãltimos resultados indicam a necessidade de novos estudos com maior nÃmero de pacientes, tempo de acompanhamento maior e estudo das cepas virais.
The polyomavirus type BK has been associated to the nephropathy in the patients transplanted renal with an incidence varying among 3 - 4% and in 60% of the cases could take to the loss of the graft. Several studies have been demonstrating the importance of the discovery of the decoy cells in these patients' urine as first selection for the viral replication making it diagnose differential between the sharp cellular rejection and the nephropathy for the BK virus. In this context, the present study aimed at to detect the presence of BKV through the observation of the decoy cells in the urine of the transplanted renal, correlating this discovery with the serum urea levels and creatinine and the histopathology features through the renal biopsy. For so much, the 50 transplanted patients' urine renal (28 men and 22 women) assisted at two hospitals of Fortaleza (Academical Hospital Walter CantÃdio and General Hospital of Fortaleza) they were analyzed as for the presence of decoy cells detected through the urinary cytology by the coloration of Papanicolau. Were the cytology analyzed and done classify in negative and positive (≥ 1 decoy cell). Result: Of the 50 cytology analyzed urinary 28 patients they were male and 22 female, alive donor's receivers (n = 43) or cadaverous (n = 7) with assertiveness for decoy cells of 24% (12 patient). Creatinine levels and increased urea, separately, they were not useful to suspect of the nephropathy for BKV or rejection of the transplant (p > 0,05). The correlation of the altered levels of urea and creatinine, with the presence or absence of the decoy cells, was significant for the statistics (p < 0,05). The biopsy revealed nephropathy for BKV in five (20%) of the patients with cells decoy in the urine and the more frequent histological discoveries were fibrose and infiltrated inflammatory mononuclear. The most employed immune suppression in the patients in study was the outline 1 (50%) (ciclosporina / azatioprina / zenapx), following for outlines 2 (16%) (MMF/FK 506/zanapax) 1 outline 3 (16%) (ciclosporina / prednizona / azatioprina). Conclusion: The assertiveness for decoy cells in this study (24%) it is coincident with the literature (8 -26%) suggesting active infection. The presence of the decoy cells in the urine was useful to define the patients' groups with possible nephropathy for BKV of those with nephropathy for rejection, because the negativity for decoy cells in the urine moves away in 100% of the cases the nephropathy for BKV, and his/her presence serves as guide to move forward in the nephropathy investigation for BKV. The biopsy confirmed in 5 of the 12 cases with decoy cells positive in the urine (20%) the nephropathy for the polyomavirus and one of them vein to lose the graft. The immunosuppressive outline used by the patients in study and the nephropathy presence for BKV was not it that more it links in the literature. Also the patients with nephropathy for BKV that used less associated outlines this condition had worse evolution. These last results indicate the need of new studies with larger number of patients, time of larger attendance and study of the stumps turn.
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Chang, Zhe-Wei y 張哲維. "Raman Spectroscopy Assisted Diagnosis in Urine Cytology". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/m3q6g4.
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碩士國立陽明大學
醫學工程研究所
97
Urine cytology (UC) is the most widely used in the detection of bladder cancer. In addition, especially for low-grade lesions, UC is of limited value beacase of operator dependency and the low sensitivity, and would affect the results. In this study, urine cytology for bladder epithelial cells in the (transitional cell carcinom 38) of normal cells (33) to determine on Raman Spectroscopy, assisted Pathology of person to determine. Urine sample is stained smears, the nucleus for its Raman signal measurement. Raman spectra show the peak 1000cm-1 (phenylalanine band), 725cm-1 (adenine, CH2 deformation), 538cm-1 (adenine, S-S ). The peak area of integration or its intensity variation decreased with the grade of cells. Raman spectroscopy to measure the results sorted according to pathology results are compared, and set into the Partial Least Squares (PLS) program analysis, the sensitivity as high as 97% and specificity 100%.725/100cm-1 area using the ratio of the results points to ROC curve (Receiver Operating Characteridtic) the sensitivity 81.8%, specificity 90.3%. Raman for this experiment confirmed that urine cytology has a good accuracy.
Libros sobre el tema "Cytologie – urine"
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Rathert, Peter. Urinary cytology: Manual and atlas. 2a ed. Berlin: Springer-Verlag, 1993.
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Schumann, G. Berry. Cytodiagnostic urinalysis of renal and lower urinary tract disorders. New York: Igaku-Shoin, 1995.
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Böcking, A., F. Hofstädter, R. Friedrichs, Peter Rathert y T. C. Telger. Urinary Cytology: Manual and Atlas. Springer London, Limited, 2012.
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Voogt, Herman J. de. Urinary Cytology: Phase Contrast Microscopy and Analysis of Stained Smears. Springer, 2012.
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Bardales, Ricardo H. Practical Urologic Cytopathology. Oxford University Press, USA, 2002.
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Bardales, Ricardo H. Practical Urologic Cytopathology. Oxford University Press, 2002.
Buscar texto completoCapítulos de libros sobre el tema "Cytologie – urine"
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Reynolds, Jordan P. "Urine Cytology". En Genitourinary Pathology, 261–68. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2044-0_21.
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Lew, Madelyn. "Urine Cytology". En Atlas of Non-Gynecologic Cytology, 221–34. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89674-8_9.
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Cross, William y Richard Khafagy. "Urine Cytology". En Imaging and Technology in Urology, 171–74. London: Springer London, 2012. http://dx.doi.org/10.1007/978-1-4471-2422-1_38.
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Narine, Nadira y Durgesh N. Rana. "Urine Cytology". En Imaging and Technology in Urology, 187–92. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-26058-2_32.
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Dioufa, Nikolina, Gina Prochilo y Suad Taraif. "Urine Cytology". En Practical Cytopathology, 119–26. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24059-2_8.
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Zhou, Haijun. "Urine Cytology". En Urinary Bladder Pathology, 147–57. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-71509-0_12.
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Raab, Stephen S., Christine N. Booth y J. Stephen Jones. "Urine Cytology". En The Urinary Tract, 293–310. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5320-8_16.
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Bubendorf, Lukas. "Urine Specimen Cytology". En Encyclopedia of Pathology, 512–14. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-33286-4_995.
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Savic, Spasenija. "Molecular Cytology Applications on Urine". En Molecular Applications in Cytology, 117–26. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-74942-6_7.
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Suh, Jungyo. "Urine Cytology and Emerging Biomarkers". En Management of Urothelial Carcinoma, 33–41. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-10-5502-7_5.
Texto completoActas de conferencias sobre el tema "Cytologie – urine"
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Fu, C. Y., B. K. Ng, S. Gulam Razul, Malini C. Olivo, Weber K. O. Lau, P. H. Tan y William Chin. "Photodynamic diagnosis of bladder cancer in ex vivo urine cytology". En Biomedical Optics 2006, editado por Nikiforos Kollias, Haishan Zeng, Bernard Choi, Reza S. Malek, Brian J. Wong, Justus F. R. Ilgner, Eugene A. Trowers et al. SPIE, 2006. http://dx.doi.org/10.1117/12.652209.
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Yang, Wei-Lei, Ching-Ming Lee, Mei-Ling Wu, Yu-Ching Peng, Ten-Jen Liu y Yi-Hsin Liu. "Abstract B13: Applying machine learning for urine cytology—computational urothelial carcinoma analysis and diagnosis". En Abstracts: AACR Special Conference on Advances in Liquid Biopsies; January 13-16, 2020; Miami, FL. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1557-3265.liqbiop20-b13.
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Jones, Eleanor, Nadira Narine, Helena O’Flynn, Chloe Barr, Kelechi Njoku, Suzanne Carter, Lisa Cornwall et al. "2022-RA-604-ESGO Urine and vaginal cytology detects endometrial cancer in women with postmenopausal bleeding". En ESGO 2022 Congress. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-esgo.153.
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NP, Arathy Menon, Pournami P.N. y Jayaraj P B. "An Inception based Urothelial Cell Classification Network for the detection of Bladder Carcinoma from Urine Cytology Microscopic Images". En 2023 International Conference on Control, Communication and Computing (ICCC). IEEE, 2023. http://dx.doi.org/10.1109/iccc57789.2023.10165205.
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Yang, Wei-Lei, Chi-Bin Li, Yen-Chuan Ou, Yi-Sheng Lin, Tang-Yi Tsao, Ming-Chen Chang, Jen-Fan Hang y Tien-Jen Liu. "Abstract PO-069: A deep learning model assists urine cytology reporting with computational estimates of the nuclear/cytoplasmic ratios of the urothelial cells based on the Paris System". En Abstracts: AACR Virtual Special Conference on Artificial Intelligence, Diagnosis, and Imaging; January 13-14, 2021. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1557-3265.adi21-po-069.
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