Bibliografías temáticas / CYP4A11 / Tesis
Siga este enlace para ver otros tipos de publicaciones sobre el tema: CYP4A11.

Tesis sobre el tema "CYP4A11"

Autor: Grafiati
Publicado: 11 de marzo de 2023

Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros

Elija tipo de fuente:

Consulte los 32 mejores tesis para su investigación sobre el tema "CYP4A11".

Junto a cada fuente en la lista de referencias hay un botón "Agregar a la bibliografía". Pulsa este botón, y generaremos automáticamente la referencia bibliográfica para la obra elegida en el estilo de cita que necesites: APA, MLA, Harvard, Vancouver, Chicago, etc.

También puede descargar el texto completo de la publicación académica en formato pdf y leer en línea su resumen siempre que esté disponible en los metadatos.

Explore tesis sobre una amplia variedad de disciplinas y organice su bibliografía correctamente.

1

Lino, Cardenas Christian Lacks. "Identification et caractérisation du polymorphisme génétique des cytochromes P450 4A11 et 4A22 (CYP4A11 et CYP4A22) et de la glycine N-acyltransférase (GLYAT)." Phd thesis, Université du Droit et de la Santé - Lille II, 2010. http://tel.archives-ouvertes.fr/tel-00630109.

Texto completo
Resumen
Afin de s'adapter à son environnement chimique, l'organisme a développé au cours de l'évolution des systèmes enzymatiques capables de transformer de nombreuses molécules étrangères ou xénobiotiques (médicaments, composés toxiques, carcinogènes...), le plus souvent de nature hydrophobe, en métabolites suffisamment hydrophiles pour être plus facilement excrétés par voie urinaire et/ou biliaire. Certaines de ces enzymes sont également impliquées dans des processus cataboliques ou de biosynthèses de composés endogènes (acides gras, rétinoïdes, stéroïdes, prostaglandines...). Ces enzymes jouent ain
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Bulsara, Daksha. "The effects of Poly IC and human interferon #alpha# on rat hepatic CYP4A1 and CYP2E1." Thesis, University of Surrey, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334347.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Parmentier, Jean-Hugues. "Répression des cytochromes P450 par les Interleukines-1 et 6 : contrôle de l'expression du CYP4A1." Nancy 1, 1995. http://www.theses.fr/1995NAN10455.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Baer, Brian R. "Autocatalytic mechanism and functional consequences of covalent heme attachment in CYP4B1 /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8176.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Graham, Richard Alan LeCluyse Edward L. "Biochemical and molecular characterization of beagle dog CYP4A." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,290.

Texto completo
Resumen
Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the School of Pharmacy." Discipline: Pharmacy; Department/School: Pharmacy.
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Hood, Steven Richard. "Isolation and characterisation of a human CYP4A gene." Thesis, University of Surrey, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359859.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Kacher, Radhia. "Role of the cholesterol hydroxylase enzyme CYP46A1 in cholesterol metabolism and neuroprotection in Huntington's disease." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS154.

Texto completo
Resumen
La maladie de Huntington (MH) est une maladie génétique autosomique dominante, causée par une augmentation du nombre de CAG sur le gène de la huntingtin. L’homéostasie du cholestérol cérébral est altérée dans la MH. L’expression de CYP46A1, enzyme neuronale catabolisant le cholestérol dans le cerveau, est diminuée dans le putamen des patients et dans le striatum de souris modèles de la MH. Après restauration de l’expression de CYP46A1 dans le striatum des souris Knock-In zQ175, les capacités locomotrices sont améliorées, l’agrégation de la huntingtine mutée est diminuée, l’atrophie neuronale e
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Heng, Yee M. "Genomic cloning and identification of a novel murine Cyp4a gene." Thesis, University of Nottingham, 1997. http://eprints.nottingham.ac.uk/10399/.

Texto completo
Resumen
The mouse cytochrome P450 4a family of genes is poorly characterised. This thesis describes a detailed study of these genes. Using primers derived from exon 1 of the mouse cyp3a10 cDNA sequence, a 1.4kb genomic fragment was cloned which contained the promoter region of the gene. Additionally, a lambda genomic library was screened with probes derived from the partial cDNA clones of the mouse cyp4a10 and cyp4a12. Originally, two classes of phage lambda clones were isolated. One clone, lambda 16, was partially sequenced and was found to contain the 3' end of the cyp4a12 gene. The second clone, la
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Fourgeux, Cynthia. "Cholestérol-24S-hydroxylase (CYP46A1) et homéostasie du cholestérol dans la rétine en conditions physiologiques et pathologiques." Phd thesis, Université de Bourgogne, 2012. http://tel.archives-ouvertes.fr/tel-00905888.

Texto completo
Resumen
Le cholestérol est le principal stérol présent dans la rétine. Dans sa forme libre, le cholestérol est distribué dans toutes les couches cellulaires de la rétine, alors que le cholestérol estérifié s'accumule essentiellement à la base de l'épithélium pigmentaire rétinien. La capacité intrinsèque de la rétine à synthétiser le cholestérol paraît limitée, ce qui implique nécessairement que des voies extra-rétiniennes participent activement à suppléer la rétine en cholestérol. Les cellules gliales de Müller contribueraient à l'apport de cholestérol aux neurones de la rétine, en particulier pour la
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Simpson, AnneMarie Elizabeth Claire Merryman. "The ontogeny of cytochrome P450 4A (CYP4A) gene expression in the rat." Thesis, University of Leicester, 1994. http://hdl.handle.net/2381/34231.

Texto completo
Resumen
Cytochrome P450s (P450s) play a major role in the metabolism of endogenous and exogenous chemicals. P450-metabolism generally converts compounds into more hydrophilic derivatives, which can then be excreted. In contrast, it can lead to the formation of reactive intermediates, which can attack cellular macromolecules leading to mutagenesis. The cytochrome P450 4A (CYP4A) subfamily encodes proteins involved in lipid metabolism. The CYP4A1, CYP4A2 and CYP4A3 genes are expressed constitutively in the adult rat, elevated expression being seen after administration of a hypolipidemic drug, clofibrate
Los estilos APA, Harvard, Vancouver, ISO, etc.
11

Alandas, Mohammed N. "An investigation into the metabolic activation of novel chloromethylindolines by isoforms of cytochrome P450. Targeting drug metabolising enzymes in cancer: analysis of the role and function of selected cytochrome P450 oxidising novel cancer prodrugs." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/6289.

Texto completo
Resumen
Introduction Cytochromes P450 (CYPs) are the major family of enzymes responsible for detoxification and metabolism of a wide range of both endogenous and xenobiotics chemicals in living organisms. The use of CYPs to activate prodrugs to cytotoxins selectively in tumours has been explored including AQ4N, Phortress and Aminoflavone. CYP1A1, CYP1B1, CYP2W1, and CYP4F11 have been identified as expressed in tumour tissue and surrounding stroma at high frequency compared to most normal tissues. Aim is to investigate the differential metabolism of novel chloromethylindoline by high frequency expre
Los estilos APA, Harvard, Vancouver, ISO, etc.
12

Bylund, Johan. "Cytochrome P450 enzymes in oxygenation of prostaglandin endoperoxides and arachidonic acid : Cloning, expression and catalytic properties of CYP4F8 and CYP4F21." Doctoral thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1066.

Texto completo
Resumen
<p>Cytochrome P450 (P450 or CYP) is an enzyme system involved in the oxygenation of a wide range of endogenous compounds as well as foreign chemicals and drugs. This thesis describes investigations of P450-catalyzed oxygenation of prostaglandins, linoleic and arachidoniacids.</p><p>The formation of bisallylic hydroxy metabolites of linoleic and arachidonic acids was studied with human recombinant P450s and with human liver microsomes. Several P450 enzymes catalyzed the formation of bisallylic hydroxy metabolites. Inhibition studies and stereochemic analysis of metabolites suggest that the enzy
Los estilos APA, Harvard, Vancouver, ISO, etc.
13

Burlot, Marie-Anne. "Modulation du métabolisme du cholestérol dans un modèle murin de Tauopathie : évaluation de la cholestérol 24-hydroxylase comme cible thérapeutique dans la maladie d’Alzheimer." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T058/document.

Texto completo
Resumen
La maladie d’Alzheimer (MA) se caractérise par une perte mnésique progressive et au plan neuropathologique par le dépôt extracellulaire de plaques amyloïdes, résultant de l’agrégation de peptides amyloïdes (Aβ), et par l’apparition d’une dégénérescence neurofibrillaire (DNF) constituée d’agrégats intraneuronaux de protéines Tau hyper et anormalement phosphorylées. L’évolution des déficits cognitifs des patients est particulièrement corrélée à la progression spatio-temporelle de la DNF. A l’heure actuelle, il n’existe aucun traitement curatif de la maladie. Le cholestérol joue un rôle central d
Los estilos APA, Harvard, Vancouver, ISO, etc.
14

Rieger, Michael A. "CYP4Z1 und CYP4Z2P: Identifizierung neuer Mitglieder der humanen Cytochrom P450 Familie mit präferentieller Expression in Brustdrüsengewebe und Mammakarzinom." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2004. http://nbn-resolving.de/urn:nbn:de:swb:14-1093525824984-91466.

Texto completo
Resumen
Bei der adjuvanten Immuntherapie soll das Immunsystem von Tumorpatienten gezielt gegen Mikrometastasen aktiviert werden, die nach der operativen Entfernung des Primärtumors im Körper verbleiben. Tumor-assoziierte Antigene (TAA) spielen dabei die zentrale Rolle. Um der Heterogenität eines Tumors in der Expression einzelner TAAs Rechnung zu tragen, werden in modernen Vakzinierungsstrategien Pools von verschiedenen TAAs eingesetzt. Für das Mammakarzinom sind aber bislang nur wenige TAAs bekannt. Auf der Suche nach unbekannten Genen mit Mamma- bzw. Mammakarzinom-restringierter Expression in der Tr
Los estilos APA, Harvard, Vancouver, ISO, etc.
15

Meyer, Anne Elisabeth [Verfasser], Helmut [Gutachter] Hanenberg, and Csaba [Gutachter] Mahotka. "Speziesübergreifende Charakterisierung des CYP4B1-Enzyms in Hinblick auf die Substratumsetzung / Anne Elisabeth Meyer ; Gutachter: Helmut Hanenberg, Csaba Mahotka." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1237495865/34.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
16

Alandas, Mohammed Nasser. "An investigation into the metabolic activation of novel chloromethylindolines by isoforms of cytochrome P450 : targeting drug metabolising enzymes in cancer : analysis of the role and function of selected cytochrome P450 oxidising novel cancer prodrugs." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/6289.

Texto completo
Resumen
Introduction: Cytochromes P450 (CYPs) are the major family of enzymes responsible for detoxification and metabolism of a wide range of both endogenous and xenobiotics chemicals in living organisms. The use of CYPs to activate prodrugs to cytotoxins selectively in tumours has been explored including AQ4N, Phortress and Aminoflavone. CYP1A1, CYP1B1, CYP2W1, and CYP4F11 have been identified as expressed in tumour tissue and surrounding stroma at high frequency compared to most normal tissues. Aim is to investigate the differential metabolism of novel chloromethylindoline by high frequency express
Los estilos APA, Harvard, Vancouver, ISO, etc.
17

Jones, Paul S. "Expression and induction, by peroxisome proliferators, of the CYP4A and PPAR gene families in mouse." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283640.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
18

Isern, Marin Joan. "Clonatge i caracterització dels gens Cyp4b1, Oatp1 i Oatp-d: nous models de regulació androgènica al ronyó de ratolí." Doctoral thesis, Universitat Autònoma de Barcelona, 2003. http://hdl.handle.net/10803/3503.

Texto completo
Resumen
Aquesta tesi es centra bàsicament en l'estudi i caracterització de tres gens de ratolí, que comparteixen la característica d'expressar-se a ronyó i d'estar regulats pels andrògens, els quals estimulen la seva expressió renal a nivell de mRNA.<br/>El primer d'ells correspon al gen Cyp4b1 -representant dels citocroms P450, enzims implicats en el metabolisme oxidatiu tan de substàncies endògenes com en la detoxificació de fàrmacs i xenobiòtics. S'ha estudiat la seva expressió en diversos teixits murins i, mitjançant hibridació in situ, s'ha localitzat la distribució del seus transcrits en el rony
Los estilos APA, Harvard, Vancouver, ISO, etc.
19

Djelti, Fathia. "Toxicité neuronale du cholestérol et physiopathologie de la maladie d’Alzheimer : analyse in vivo des conséquences de l’inhibition de la cholestérol-24-hydroxylase." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T026/document.

Texto completo
Resumen
Le vieillissement normal s’accompagne d’une diminution du contenu du cholestérol cérébral. Au contraire, une accumulation de cholestérol est associée aux processus toxiques dans plusieurs pathologies dégénératives (maladie d’Huntington, maladie de Parkinson, épilepsie, maladie de Niemann Pick de type C, maladie d’Alzheimer). De plus, les parallèles étroits existent entre la physiopathologie moléculaire de la maladie d’Alzheimer et celle de la maladie de Niemann Pick de type C, maladie de l’homéostasie du cholestérol. Ainsi on retrouve dans ces deux pathologies une hyperphosphorylation de la pr
Los estilos APA, Harvard, Vancouver, ISO, etc.
20

Warasiha, Benjamart. "Cytochrome P450 mRNA profile in human breast cancer cell lines." Thesis, Robert Gordon University, 2008. http://hdl.handle.net/10059/364.

Texto completo
Resumen
Cytochrome P450 enzymes (P450s) are involved in cancer development and treatment due to their roles in the oxidative metabolism of various endogenous (e.g. oestrogen) and exogenous (e.g. tamoxifen) compounds. It is well-known that intermediate P450 metabolites derived from oestrogen metabolism are associated with breast carcinogenesis. The main aim of this project was to profile the cytochrome P450 and P450-regulatory nuclear receptor mRNAs in a series of breast cancer cell lines (BCCs) and compare this profile with normal breast cells. This study used the qualitative reverse transcriptasepoly
Los estilos APA, Harvard, Vancouver, ISO, etc.
21

Lundell, Kerstin. "Cytochrome P450 Enzymes in Bile Acid Biosynthesis and Fatty Acid Metabolism : Studies on Members of the Porcine CYP4A and CYP8B Subfamilies." Doctoral thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3419.

Texto completo
Resumen
<p>The present investigation is devoted to studies on porcine members of the cytochrome P450 4A (CYP4A) and CYP8B1 subfamilies, which are involved in bile acid biosynthesis and fatty acid metabolism. </p><p>Hyocholic acid is considered to fulfil the requirements for trihydroxy bile acids in the domestic pig (Sus scrofa) in the absence of cholic acid. Hyocholic acid is a 6α-hydroxylated product of chenodeoxycholic acid and the enzyme catalyzing the 6α-hydroxylation was cloned and found to be an atypical member of the CYP4A subfamily. The primary structure of this porcine enzyme, designated CYP4
Los estilos APA, Harvard, Vancouver, ISO, etc.
22

Schmidt, Cosima. "Identifizierung, molekulare Eigenschaften und Regulation einer renalen 20-Hydroxyeicosatetraensäure-Synthase." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15876.

Texto completo
Resumen
Cytochrom P450 (CYP)-Enzyme hydroxylieren und epoxydieren Arachidonsäure (AA) zu bioaktiven Metaboliten wie 20-Hydroxyeicosatetraensäure (20-HETE) und Epoxyeicosatriensäuren (EETs). Diese CYP-abhängigen Eicosanoide fungieren als Mediatoren bei der Regulation der Gefäß-, Nieren- und Herzfunktion. Hauptziel der vorliegenden Arbeit war es, die Identität der 20-HETE bildenden CYP-Isoformen in der Mausniere aufzuklären. Ein weiterer Schwerpunkt war die Bestimmung von Veränderungen im Metabolismus CYP-abhängiger Eicosanoide in Tiermodellen des akuten Nieren- und Herzversagens. Zur Identifizierung
Los estilos APA, Harvard, Vancouver, ISO, etc.
23

Brito, Sara Filipa Correia de. "Therapeutic rescue of NPC phenotype by CYP46A1 cerebellar expression." Master's thesis, 2020. http://hdl.handle.net/10362/112894.

Texto completo
Resumen
Niemann-Pick type C (NPC) disease is a rare neurogenerative disorder characterized by accumulation of cholesterol and other lipids in late endosomes/lysosomes. There are still limited therapeutic options available for NPC, but as it causes motor and intellectual impairment and premature death there is a high interest in the development of therapeutic strategies for this disease. CYP46A1 is a key enzyme involved in cholesterol homeostasis, which converts cholesterol to 24 (S)-hydroxycholesterol, being responsible for half of cholesterol turnover and the major brain cholesterol elimination pathw
Los estilos APA, Harvard, Vancouver, ISO, etc.
24

Lee, JungA. "Alteration of cholesterol disposition by chlordecone is not explained by induction of cyp7a or cyp4a1." Thesis, 2002. http://hdl.handle.net/1957/32450.

Texto completo
Resumen
Liver X receptor (LXR), farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR) are adopted orphan nuclear receptors that function as lipid sensors. These receptors respond to cellular lipid levels and regulate the expression of target gene. Previously, it was demonstrated that low doses of chlordecone (CD) pretreatment disturbed exogenous cholesterol distribution and cellular lipid transport, storage and metabolism pathway. The aim of this study was to determine whether low doses of CD affect nuclear receptor (LXR��/FXR or PPAR��)-mediated lipid homeostasis. Thus, hep
Los estilos APA, Harvard, Vancouver, ISO, etc.
25

Moutinho, Miguel Alves da Silva de Carvalho 1986. "Control of neuronal signalling pathways by CYP46A1, an enzime involved in brain cholesterol homeostasis." Doctoral thesis, 2016. http://hdl.handle.net/10451/23976.

Texto completo
Resumen
Tese de doutoramento, Farmácia (Biologia Celular e Molecular), Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Cholesterol is an essential molecule in central nervous system physiology and cell signalling, with a wide range of roles, such as being an essential component of cell membranes, lipid rafts and myelin sheets, or serving as a precursor for neurosteroids. The brain relies mainly on de novo cholesterol synthesis and eliminates cholesterol through its conversion to 24(S)-hydroxycholesterol (24OHC), which readily crosses the blood brain barrier into circulation. The enzyme that cat
Los estilos APA, Harvard, Vancouver, ISO, etc.
26

Silva, Inês Milagre da 1980. "Identification of the regulatory mechanisms and factors involved in the brain-specific expression of CYP46A1." Doctoral thesis, 2010. http://hdl.handle.net/10451/3006.

Texto completo
Resumen
Tese de doutoramento, Farmácia (Biologia Celular e Molecular), Universidade de Lisboa, Faculdade de Farmácia, 2011<br>Cholesterol has a crucial role in central nervous system physiology and cell signaling, and many studies correlate alterations in brain cholesterol homeostasis with neurodegenerative diseases. The CYP46A1 gene codes for the cholesterol 24-hydroxylase (CYP46A1), a cytochrome P450 specifically expressed in neurons, that is responsible for the majority of brain cholesterol turnover. However, despite its physiological importance, the molecular mechanisms underlying the human CYP46A
Los estilos APA, Harvard, Vancouver, ISO, etc.
27

Elorza, Setiembre Delfina. "Caracterización del patrón de expresión del GEN cyp46a1 durante el envejecimiento en cerebro de ratón." Bachelor's thesis, 2017. http://hdl.handle.net/11086/5628.

Texto completo
Resumen
Tesina (Grado en Ciencias Biológicas)--Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Lugar de Trabajo: Instituto de Investigación Médica Mercedes y Martín Ferreyra. INIMEC-CONICET-U.N.C. 2017. 56 h.; ils.; grafs.; tabls. Contiene Referencias Bibliográficas.<br>Durante el envejecimiento se producen cambios en la composición lipídica de membranas neuronales. En la mayoría de los casos, estas alteraciones lipídicas han sido relacionadas a la aparición de problemas cognitivos, tanto en envejecimiento regular como patológico. Específicamente, en el laboratori
Los estilos APA, Harvard, Vancouver, ISO, etc.
28

Nunes, MJ. "Transcriptional regulatory mechanisms involved in CYP46A1 up-regulation by histone deacetylase inhibitors:from chromatin structure to transcription factors." Doctoral thesis, 2012. http://hdl.handle.net/10451/8071.

Texto completo
Resumen
Tese de doutoramento, Farmácia (Biologia Celular e Molecular), Universidade de Lisboa, Faculdade de Farmácia, 2012<br>Apart from being an essential component of cellular membranes and having a role as a signaling molecule, cholesterol is also the precursor of several bioactive molecules that include bile acids, steroid hormones, oxysterols and vitamin D. In the brain constant levels of this sterol are required for normal functioning and the homeostasis is maintained, in part, by an efficient blood-brain barrier that prevents exchanges with lipoprotein cholesterol from circulation. For that rea
Los estilos APA, Harvard, Vancouver, ISO, etc.
29

Rieger, Michael A. [Verfasser]. "CYP4Z1 und CYP4Z2P : Identifizierung neuer Mitglieder der humanen Cytochrom-P450-Familie mit präferentieller Expression in Brustdrüsengewebe und Mammakarzinom / von Michael A. Rieger." 2004. http://d-nb.info/97224042X/34.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
30

Castro, Telma Cristina Aureliano. "Role of neuronal cholesterol in peripheric metabolic tissues." Master's thesis, 2021. http://hdl.handle.net/10400.1/17754.

Texto completo
Resumen
The brain possesses 20% of whole-body cholesterol, becoming the richest cholesterol organ in our body. Due to the Blood Brain Barrier, the cholesterol has its own way to synthesize and degrade cholesterol, in order to maintain its homeostasis. Cholesterol is synthesized through de novo synthesis in the brain and transported out of the brain in the form of oxysterols, more specifically 24-hydroxycholesterol (24-OHC). This process is acomplished through CYP46A1, a protein of the CYP450 family. Alterations in cholesterol homeostasis can lead to metabolic abnormalities, such as obesity, infl
Los estilos APA, Harvard, Vancouver, ISO, etc.
31

Pereira, Adriana Arrulo. "Silencing of cypx gene in the hypothalamus and its impact on whole-body metabolism." Master's thesis, 2020. http://hdl.handle.net/10400.1/14688.

Texto completo
Resumen
Cholesterol metabolism is tightly controlled in the brain, through an equilibrium of cholesterol de novo synthesis and cholesterol efflux. Most of the cholesterol in the brain is in myelin sheaths to insulate axons and to maintain their morphology and synaptic transmission. The importance of cholesterol in the brain is highlighted by the fact that dysfunctions in its metabolism homeostasis are correlated with different neurodegenerative disorders. The hypothalamus, specially the ARC, is the principal brain region in the control of whole-body energy homeostasis, having a crucial role in m
Los estilos APA, Harvard, Vancouver, ISO, etc.
32

Araujo, Renata Sandres de Souza. "Controlling the effect of injection in the hypothalamus of diet induced obese mice." Master's thesis, 2020. http://hdl.handle.net/10400.1/17181.

Texto completo
Resumen
Diet-induced obesity causes a central inflammatory process in the brain, more specifically in the arcuate nucleus of the hypothalamus; in addition to substantially altering cholesterol homeostasis in the brain. The brain is one of the richest organs in cholesterol and cholesterol homeostasis has proved to be very important not only to maintain healthy brain physiology, but also directly influencing the whole-body homeostasis. In addition, several metabolic disorders are correlated with different neurodegenerative diseases. Cholesterol in the brain is converted primarily to 24-hydroxycholestero
Los estilos APA, Harvard, Vancouver, ISO, etc.
Ofrecemos descuentos en todos los planes premium para autores cuyas obras están incluidas en selecciones literarias temáticas. ¡Contáctenos para obtener un código promocional único!

Pasar a la bibliografía