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1

Dereje, Degnet Melese, Carlotta Pontremoli, Maria Jesus Moran Plata, Sonja Visentin, and Nadia Barbero. "Polymethine dyes for PDT: recent advances and perspectives to drive future applications." Photochemical & Photobiological Sciences 21, no. 3 (2022): 397–419. http://dx.doi.org/10.1007/s43630-022-00175-6.

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AbstractIt has been proved that the effectiveness of photodynamic therapy (PDT) is closely related to the intrinsic features of the photosensitizer (PS). Over the recent years, several efforts have been devoted to the discovery of novel and more efficient photosensitizers showing higher efficacy and lower side effects. In this context, squaraine and cyanine dyes have been reported to potentially overcome the drawbacks related to the traditional PSs. In fact, squaraines and cyanines are characterized by sharp and intense absorption bands and narrow emission bands with high extinction coefficien
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2

Dülcks, Thomas, Walter Grahn, Hans-Hermann Johannes, et al. "Mass Spectrometry of Oligomeric Cyanines and Squaraines of the Indole Series: Fast Atom Bombardment-Induced Chemical Reactions." Zeitschrift für Naturforschung B 57, no. 4 (2002): 393–98. http://dx.doi.org/10.1515/znb-2002-0405.

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Fast atom bombardment (FAB) has been used for mass spectrometric characterization of oligomeric cyanines and squaraines of the indole series which are linked by different aromatic spacers. Markedly different results were obtained for the oligomers and for the corresponding monomers. In addition to the expected mono-anions and mono-cations, ions of high relative abundance were detected which can only be explained on the basis of FAB-induced chemical reactions of the initial oligomers. Formation of allenes, hydrogenation and dehydrogenation, respectively, is characteristic for this class of comp
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3

Lima, Eurico, Renato E. Boto, Diana Ferreira, et al. "Quinoline- and Benzoselenazole-Derived Unsymmetrical Squaraine Cyanine Dyes: Design, Synthesis, Photophysicochemical Features and Light-Triggerable Antiproliferative Effects against Breast Cancer Cell Lines." Materials 13, no. 11 (2020): 2646. http://dx.doi.org/10.3390/ma13112646.

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Photodynamic therapy is an innovative treatment approach broadly directed towards oncological diseases. Its applicability and efficiency are closely related to the interaction of three main components, namely a photosensitizer, light and molecular triplet oxygen, which should drive cell death. Recently, several studies have demonstrated that squaraine cyanine dyes have a set of photophysical and photochemical properties that have made of these compounds’ potential photosensitizers for this therapeutic modality. In the present research work, we describe the synthesis and characterization of fou
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4

Lange, Natalia, Wojciech Szlasa, Jolanta Saczko, and Agnieszka Chwiłkowska. "Potential of Cyanine Derived Dyes in Photodynamic Therapy." Pharmaceutics 13, no. 6 (2021): 818. http://dx.doi.org/10.3390/pharmaceutics13060818.

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Photodynamic therapy (PDT) is a method of cancer treatment that leads to the disintegration of cancer cells and has developed significantly in recent years. The clinically used photosensitizers are primarily porphyrin, which absorbs light in the red spectrum and their absorbance maxima are relatively short. This review presents group of compounds and their derivatives that are considered to be potential photosensitizers in PDT. Cyanine dyes are compounds that typically absorb light in the visible to near-infrared-I (NIR-I) spectrum range (750–900 nm). This meta-analysis comprises the current s
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5

D. Martins, Tiago, Eurico Lima, Renato E. Boto, et al. "Red and Near-Infrared Absorbing Dicyanomethylene Squaraine Cyanine Dyes: Photophysicochemical Properties and Anti-Tumor Photosensitizing Effects." Materials 13, no. 9 (2020): 2083. http://dx.doi.org/10.3390/ma13092083.

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Photodynamic therapy is a medical modality developed for the treatment of several diseases of oncological and non-oncological etiology that requires the presence of a photosensitizer, light and molecular oxygen, which combined will trigger physicochemical reactions responsible for reactive oxygen species production. Given the scarcity of photosensitizers that exhibit desirable characteristics for its potential application in this therapeutic strategy, the main aims of this work were the study of the photophysical and photochemical properties and the photobiological activity of several dicyanom
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6

Qiao, Weiguo, and Zhong’an Li. "Recent Progress of Squaraine-Based Fluorescent Materials and Their Biomedical Applications." Symmetry 14, no. 5 (2022): 966. http://dx.doi.org/10.3390/sym14050966.

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Squaraines (SQs) are unusual cyanine dyes with a unique resonance-stabilized zwitterionic structure. These dyes have attracted significant attention in the fields of organic electronics and organic photonics, due to their facile synthesis, intense and narrow visible and near-infrared absorption/emission, high photostability, low biotoxicity, etc. In this review, we summarize the recent progress of SQ-based fluorescent materials and their biomedical applications. After a brief introduction to SQs, general synthetic routes and design principles of SQ-based fluorescent materials, as well as their
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7

Terpetschnig, E. "Synthesis and characterization of unsymmetrical squaraines: a new class of cyanine dyes." Dyes and Pigments 21, no. 3 (1993): 227–34. http://dx.doi.org/10.1016/0143-7208(93)85016-s.

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8

TERPETSCHNIG, E., and J. R. LAKOWICZ. "ChemInform Abstract: Synthesis and Characterization of Unsymmetrical Squaraines: A New Class of Cyanine Dyes." ChemInform 25, no. 2 (2010): no. http://dx.doi.org/10.1002/chin.199402240.

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9

Ma, Y. L., Shi Xue Ren, and Shi Yan Han. "Photo-Degradation Alkali Lignin by Bis-(2-Methyl Quinoline) Squarylium Cyanine TiO2 Photocatalyst in Sunlight." Advanced Materials Research 838-841 (November 2013): 2717–20. http://dx.doi.org/10.4028/www.scientific.net/amr.838-841.2717.

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Photo-degradation alkali lignin was prepared in sunlight by the system of TiO2 and squaraine dye (QSC). The influence of the ratio of QSC to TiO2 on the solar energy conversion efficiency was tested; the principle of degradation alkali lignin by TiO2 photocatalyst in sunlight was researched. The results showed that the number-average and mass-average molecular mass of degradation alkali lignin and the control lignin were 1,548 and 2,822, respectively, the phenolic hydroxyl of degradation alkali lignin is 5.63% with the control is 4.64%, and alcoholic hydroxyl of degradation alkali lignin is 3.
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10

Grynyov, Roman S., Alexander V. Sorokin, Gleb Ya Guralchuk, Svetlana L. Yefimova, Igor A. Borovoy, and Yuri V. Malyukin. "Squaraine Dye as an Exciton Trap for Cyanine J-Aggregates in a Solution." Journal of Physical Chemistry C 112, no. 51 (2008): 20458–62. http://dx.doi.org/10.1021/jp809124m.

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11

PONTREMOLI, Carlotta, Maria Jesus MORAN PLATA, Degnet Melese DEREJE, et al. "The Effect of Substitutions on Squaraine and Cyanine dyes on their Photodynamic Activity." Photodiagnosis and Photodynamic Therapy 41 (March 2023): 103484. http://dx.doi.org/10.1016/j.pdpdt.2023.103484.

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12

PONTREMOLI, Carlotta, Maria Jesus MORAN PLATA, Degnet Melese DEREJE, et al. "The Effect of Substitutions on Squaraine and Cyanine dyes on their Photodynamic Activity." Photodiagnosis and Photodynamic Therapy 41 (March 2023): 103385. http://dx.doi.org/10.1016/j.pdpdt.2023.103385.

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13

Saikiran, M., D. Sato, S. S. Pandey, and T. Kato. "Photophysical investigations of squaraine and cyanine dyes and their interaction with bovine serum albumin." Journal of Physics: Conference Series 704 (April 2016): 012012. http://dx.doi.org/10.1088/1742-6596/704/1/012012.

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14

Meador, William E., Shane A. Autry, Riley N. Bessetti, et al. "Water-Soluble NIR Absorbing and Emitting Indolizine Cyanine and Indolizine Squaraine Dyes for Biological Imaging." Journal of Organic Chemistry 85, no. 6 (2020): 4089–95. http://dx.doi.org/10.1021/acs.joc.9b03108.

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15

Markova, Larysa I., Ewald A. Terpetschnig, and Leonid D. Patsenker. "Comparison of a series of hydrophilic squaraine and cyanine dyes for use as biological labels." Dyes and Pigments 99, no. 3 (2013): 561–70. http://dx.doi.org/10.1016/j.dyepig.2013.06.022.

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16

Trusova, V., U. Malovytsia, P. Kuznietsov, et al. "Computational Study of Drug Delivery Systems with Radionuclide and Fluorescence Imaging Modalities. II. Doxorubicin Delivery Systems Based on Albumin and Transferrin." East European Journal of Physics, no. 1 (March 3, 2025): 376–82. https://doi.org/10.26565/2312-4334-2025-1-46.

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This study explores the development of advanced protein-based drug delivery systems for doxorubicin (DOX), an anticancer agent, incorporating both radionuclide (technetium-99m complexes) and fluorescence (Methylene Blue (MB), Indocyanine Green (IG), cyanine AK7-5 and squaraine SQ1) imaging modalities. Building upon previous research on albumin-based carriers, this work expands the scope by introducing transferrin (TRF) as a complementary protein component to create a more sophisticated and targeted delivery platform. Molecular docking technique was employed to design and characterize the multi
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17

Friães, Sofia, Eurico Lima, Renato E. Boto, et al. "Photophysicochemical Properties and In Vitro Phototherapeutic Effects of Iodoquinoline- and Benzothiazole-Derived Unsymmetrical Squaraine Cyanine Dyes." Applied Sciences 9, no. 24 (2019): 5414. http://dx.doi.org/10.3390/app9245414.

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The search to replace conventional cancer treatment therapies, such as chemotherapy, radiotherapy and surgery has led over the last ten years, to a substantial effort in the development of several classes of photodynamic therapy photosensitizers with desired photophysicochemical and photobiological properties. Herein we report the synthesis of 6-iodoquinoline- and benzothiazole-based unsymmetrical squaraine cyanine dyes functionalized with amine groups located in the four-membered central ring. Their photodegradation and singlet oxygen production ability, as well as their in vitro photocytotox
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18

Reddington, Mark V. "Synthesis and Properties of Phosphonic Acid Containing Cyanine and Squaraine Dyes for Use as Fluorescent Labels." Bioconjugate Chemistry 18, no. 6 (2007): 2178–90. http://dx.doi.org/10.1021/bc070090y.

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19

Lima, Eurico, Octávio Ferreira, Vanessa S. D. Gomes, et al. "Synthesis and in vitro evaluation of the antitumoral phototherapeutic potential of squaraine cyanine dyes derived from indolenine." Dyes and Pigments 167 (August 2019): 98–108. http://dx.doi.org/10.1016/j.dyepig.2019.04.007.

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20

Liu, Taihong, Xinglei Liu, Maira A. Valencia, Binglin Sui, Yuanwei Zhang, and Kevin D. Belfield. "Far-Red-Emitting TEG-Substituted Squaraine Dye: Synthesis, Optical Properties, and Selective Detection of Cyanide in Aqueous Solution." European Journal of Organic Chemistry 2017, no. 27 (2017): 3957–64. http://dx.doi.org/10.1002/ejoc.201700649.

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21

Momicchioli, Fabio, Aleksandr S. Tatikolov, Davide Vanossi, and Glauco Ponterini. "Electronic structure and photochemistry of squaraine dyes: basic theoretical analysis and direct detection of the photoisomer of a symmetrical squarylium cyanine." Photochemical & Photobiological Sciences 3, no. 4 (2004): 396. http://dx.doi.org/10.1039/b315605b.

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22

Trusova, V., U. Tarabara, I. Karnaukhov, et al. "Computational Study of Drug Delivery Systems with Radionuclide and Fluorescence Imaging Modalities. I. Albumin-Based Systems for Doxorubicin Delivery." East European Journal of Physics, no. 4 (December 8, 2024): 447–53. https://doi.org/10.26565/2312-4334-2024-4-54.

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Molecular docking and molecular dynamics methodologies were employed to design and evaluate delivery systems for the antineoplastic agent doxorubicin (DOX) utilizing human serum albumin (HSA) as the carrier. To engineer a drug delivery system (DDS) with dual imaging modalities, complexes of the radionuclide technetium-99m (TCC) and near-infrared (NIR) fluorescent dyes, including indocyanine green (IG), methylene blue (MB), heptamethine cyanine dye AK7-5, and squaraine dye SQ1, were integrated into the protein nanocarriers. The highest binding affinities to the proteins were identified for TCC
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23

Bigelow, Richard W., and Hans-Joachim Freund. "An MNDO and CNDO / S(S + DES CI) study on the structural and electronic properties of a model squaraine dye and related cyanine." Chemical Physics 107, no. 2-3 (1986): 159–74. http://dx.doi.org/10.1016/0301-0104(86)85001-7.

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24

Lei, Yuqing, Yuqian Wang, Sophie K. Hill, Zihe Cheng, Qiao Song, and Sébastien Perrier. "Supra‐Fluorophores: Ultrabright Fluorescent Supramolecular Assemblies Derived from Conventional Fluorophores in Water." Advanced Materials, February 28, 2024. http://dx.doi.org/10.1002/adma.202401346.

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AbstractFluorescent organic nanoparticles (NPs) with exceptional brightness hold significant promise for demanding fluorescence bioimaging applications. Although considerable efforts have been invested in developing novel organic dyes with enhanced performance, augmenting the brightness of conventional fluorophores is still one of the biggest challenges to overcome. In this study, we present a supramolecular strategy for constructing ultrabright fluorescent nanoparticles in aqueous media (referred to as “Supra‐fluorophores”) derived from conventional fluorophores. To achieve this, we have empl
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25

Tan, Wenle, Yue Yu, Tianyuan Shi, et al. "Achieving Ultra‐Narrow‐Band Deep‐Red Electroluminescence By a Soliton‐type Dye Squaraine." Advanced Materials, September 23, 2024. http://dx.doi.org/10.1002/adma.202410418.

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AbstractDue to the soliton‐like electronic structural characteristics, cyanine dyes typically exhibit spectral behaviors such as large molar extinction coefficients, narrow spectra, and high fluorescence efficiency. However, their extensive applications as emitters in electroluminescence are largely ignored due to their serious emission quenching in the aggregation state. Herein, it is reported a squaraine dye (a type of cyanine) SQPhEt. At different solution concentrations, the unusual decrease in full‐width at half‐maxima (FWHM) with increasing Stokes shift indicates the fluorescence quenchi
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26

Meador, William E., Karina Kapusta, Iyanuoluwani Owolabi, et al. "Ultra Bright Near‐Infrared Sulfonate‐Indolizine Cyanine‐ and Squaraine‐Albumin Chaperones: Record Quantum Yields and Applications." ChemPhotoChem, June 20, 2022. http://dx.doi.org/10.1002/cptc.202200127.

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27

Meador, William E., Karina Kapusta, Iyanuoluwani Owolabi, et al. "Ultra‐Bright Near‐Infrared Sulfonate‐Indolizine Cyanine‐ and Squaraine‐Albumin Chaperones: Record Quantum Yields and Applications." ChemPhotoChem 6, no. 9 (2022). http://dx.doi.org/10.1002/cptc.202200237.

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28

Meador, William E., Karina Kapusta, Iyanuoluwani Owolabi, et al. "Front Cover: Ultra‐Bright Near‐Infrared Sulfonate‐Indolizine Cyanine‐ and Squaraine‐Albumin Chaperones: Record Quantum Yields and Applications (ChemPhotoChem 9/2022)." ChemPhotoChem 6, no. 9 (2022). http://dx.doi.org/10.1002/cptc.202200238.

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