Literatura académica sobre el tema "CPA"

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Artículos de revistas sobre el tema "CPA"

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Ren, Jiawei, Xinbo Gao, Liming Chen, Huishan Lin, Yao Liu, Yuying Zhou, Yunru Liao, Chunzi Xie, Chengguo Zuo, and Mingkai Lin. "Characteristics of the Ciliary Body in Healthy Chinese Subjects Evaluated by Radial and Transverse Imaging of Ultrasound Biometric Microscopy." Journal of Clinical Medicine 11, no. 13 (June 27, 2022): 3696. http://dx.doi.org/10.3390/jcm11133696.

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Background: The imaging and analysis of the ciliary body (CB) are valuable in many potential clinical applications. This study aims to demonstrate the anatomy characteristics of CB using radial and transverse imaging of ultrasound biometric microscopy (UBM) in healthy Chinese subjects, and to explore the determining factors. Methods: Fifty-four eyes of 30 healthy Chinese subjects were evaluated. Clinical data, including age, body mass index (BMI), intraocular pressure (IOP), axial length (AL), and lens thickness (LT), were collected. Radial and transverse UBM measurements of the ciliary body were performed. Anterior chamber depth (ACD), ciliary sulcus diameter (CSD), ciliary process length (CPL), ciliary process density (CPD), ciliary process area (CPA), ciliary muscle area (CMA), ciliary body area (CBA), ciliary body thickness (CBT0, CBT1, and CBTmax), anterior placement of ciliary body (APCB), and trabecular-ciliary angle (TCA) of four (superior, nasal, inferior, and temporal) quadrants were measured. Results: The average CPL was 0.513 ± 0.074 mm, and the average CPA was 0.890 ± 0.141 mm2. CPL and CPA tended to be longer and larger in the superior quadrant (p < 0.001) than in the other three quadrants. Average CPL was significantly correlated with AL (r = 0.535, p < 0.001), ACD (r = 0.511, p < 0.001), and LT (r = −0.512, p < 0.001). Intraclass correlation coefficient (ICC) scores were high for CPL (0.979), CPD (0.992), CPA (0.966), CMA (0.963), and CBA (0.951). Conclusions: In healthy Chinese subjects, CPL was greatest in the superior quadrant, followed by the inferior, temporal, and nasal quadrants, and CPA was largest in the superior quadrant, followed by the tempdoral, inferior, and nasal quadrants. Transverse UBM images can be used to measure the anatomy of the ciliary process with relatively good repeatability and reliability.
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Kim, JungHoon, KyungSik Yoon, IkSu Seo, and KyunKyung Lee. "Estimating The Ratio of The CPA Distance to Velocity for Underwater Target using Bearing CPA." Journal of the Institute of Electronics and Information Engineers 53, no. 6 (June 25, 2016): 146–51. http://dx.doi.org/10.5573/ieie.2016.53.6.146.

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Iqbal, Nousheen, Muhammad Irfan, Ammar Mushtaq, and Kauser Jabeen. "Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan." Journal of Fungi 6, no. 2 (March 26, 2020): 41. http://dx.doi.org/10.3390/jof6020041.

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The incidence of chronic pulmonary aspergillosis (CPA) is especially increasing in high tuberculosis (TB) burden countries. Despite a high estimated CPA burden in Pakistan, actual data on CPA are not available. The aim of the current study is to determine the underlying conditions and clinical spectrum of CPA at a tertiary care hospital in Karachi, Pakistan. This is a retrospective chart review study in patients admitted with CPA from January 2012 to December 2017. A total of 67 patients were identified during the study period. Mean age of CPA patients was 45.9 ± 15 years, 44 (65.7%) were male and 19 (28.4%) had diabetes. The most common type of CPA was simple aspergilloma (49.2%) followed by chronic cavitary pulmonary aspergillosis (CCPA) (44.7%). TB was the underlying cause of CPA in 58 (86.6%) patients followed by bronchiectasis caused by allergic bronchopulmonary aspergillosis (ABPA) 8 (11.9%). Aspergillus flavus was identified in 17 (47.2%), followed by A. fumigatus in 13 (36.1%) CPA patients. Isolation of multiple Aspergillus species was found in 10 (25.6%) patients. Itraconazole was given in 27 (40.3%) patients and a combination therapy of itraconazole and surgery was given in 21 (31.34%) patients. We found aspergilloma and CCPA as the most prevalent forms of CPA in our setting. Further large prospective studies using Aspergillus specific immunoglobulin G (IgG) antibodies testing are required for better understanding of CPA in Pakistan.
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Xu, Zitong, JunFan Fang, Xuaner Xiang, HaiJu Sun, SiSi Wang, Jianqiao Fang, and Junying Du. "Electroacupuncture Alleviates Pain-Related Emotion by Upregulating the Expression of NPS and Its Receptor NPSR in the Anterior Cingulate Cortex and Hypothalamus." Evidence-Based Complementary and Alternative Medicine 2020 (February 10, 2020): 1–16. http://dx.doi.org/10.1155/2020/8630368.

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Objective. Electroacupuncture (EA) is reported effective in alleviating pain-related emotion; however, the underlying mechanism of its effects still needs to be elucidated. The NPS-NPSR system has been validated for the involvement in the modulation of analgesia and emotional behavior. Here, we aimed to investigate the role of the NPS-NPSR system in the anterior cingulate cortex (ACC), hypothalamus, and central amygdala (CeA) in the use of EA to relieve affective pain modeled by complete Freund’s adjuvant- (CFA-) evoked conditioned place aversion (C-CPA). Materials and Methods. CFA injection combined with a CPA paradigm was introduced to establish the C-CPA model, and the elevated O-maze (EOM) was used to test the behavioral changes after model establishment. We further explored the expression of NPS and NPSR at the protein and gene levels in the brain regions of interest by immunofluorescence staining and quantitative real-time PCR. Results. We observed that EA stimulation delivered to the bilateral Zusanli (ST36) and Kunlun (BL60) acupoints remarkably inhibited sensory pain, pain-evoked place aversion, and anxiety-like behavior. The current study showed that EA significantly enhanced the protein expression of this peptide system in the ACC and hypothalamus, while the elevated expression of NPSR protein alone was just confined to the affected side in the CeA. Moreover, EA remarkably upregulated the mRNA expression of NPS in CeA, ACC, and hypothalamus and NPSR mRNA in the hypothalamus and CeA. Conclusions. These data suggest the effectiveness of EA in alleviating affective pain, and these benefits may at least partially be attributable to the upregulation of the NPS-NPSR system in the ACC and hypothalamus.
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Feser, W., RS Kerdar H. Blode, and R. Reimann. "Formation of DNA-adducts by selected sex steroids in rat liver." Human & Experimental Toxicology 15, no. 7 (July 1996): 556–62. http://dx.doi.org/10.1177/096032719601500702.

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1 We are reporting investigations into the potential of the steroid hormones chlormadinone acetate (CMA), cyproterone acetate (CPA), ethinylestradiol (EE2) gestodene (GEST), megestrol acetate (MGA), norethis terone acetate (NET-Ac), estradiol (E 2), and progester one (P) to form DNA-adducts in rat liver in vivo. 2 Compound-related DNA-adduct spots were detected in male and female rat liver following CMA, CPA, and MGA using the 32P-postlabeling-technique. Substance- specific DNA-adducts were also observed in male rats after administration of E2. The other compounds showed no DNA-adduct formation. After treatment with CMA, CPA or MGA, the relative adduct labeling (RAL) differed sex- and substance-specifically.
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Lee, Meng-Rui, Hung-Ling Huang, Li-Ta Keng, Hsu-Liang Chang, Chau-Chyun Sheu, Pin-Kuei Fu, Jann-Yuan Wang, Inn-Wen Chong, Jin-Yuan Shih, and Chong-Jen Yu. "Establishing Aspergillus-Specific IgG Cut-Off Level for Chronic Pulmonary Aspergillosis Diagnosis: Multicenter Prospective Cohort Study." Journal of Fungi 7, no. 6 (June 12, 2021): 480. http://dx.doi.org/10.3390/jof7060480.

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Objectives: Aspergillus-specific IgG (Asp-IgG) cut-off level in diagnosing chronic pulmonary aspergillosis (CPA) remains unknown. Methods: We prospectively recruited participants with clinical suspicion of CPA in three centers in Taiwan during 2019 June to 2020 August. Serum Aspergillus fumigatus-specific IgG (Asp-IgG) (Phadia, Uppsala, UPPS, Sweden) was examined. Optimal cut-off level was determined by Youden’s index and validated. Results: A total of 373 participants were recruited. In the derivation cohort (n = 262), Asp-IgG had an area under the receiver-operating-characteristic curve (AUC) of 0.832. The optimal cut-off level was 40.5 mgA/L. While applying this cut-off level to the validation cohort (n = 111), the sensitivity and specificity were 86.7% and 80.2%. Lowering the cut-off level from 40.5 to 27 mgA/L, the sensitivity was steady (30/36, 83.3% to 31/36, 86.1%) while specificity dropped from 81.9% (276/337) to 63.5% (214/337). Restricting CPA diagnosis to only chronic cavitary pulmonary aspergillosis (CCPA) and chronic fibrosing pulmonary aspergillosis (CFPA) yielded a cut-off level of 42.3 mgA/L in the derivation cohort with a sensitivity of 100% and specificity of 84.4% in the validation cohort. Conclusions: Serum Asp-IgG performs well for CPA diagnosis and provides a low false-positive rate when using a higher cut-off level (preferably around 40 mgA/L).
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González García, Pablo, Julia Fernández-Navarro, Mónica Bru-Arca, Elisa Álvarez-Artero, Pablo Solís, María Pía Roiz Mesones, Juan Luis Muñoz Bellido, María Antonia García Castro, Moncef Belhassen-García, and Javier Pardo Lledías. "Three-Month Mortality in Nonhaematological Patients with Chronic Pulmonary Aspergillosis: Differences between Subtypes." Journal of Fungi 10, no. 10 (October 10, 2024): 706. http://dx.doi.org/10.3390/jof10100706.

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Objectives: Chronic pulmonary aspergillosis (CPA) is a fungal lung infection characterised by the slowly progressing destruction of the lung parenchyma and has four main subtypes. The objective of this work was to evaluate the epidemiology of CPA in our area and evaluate the involvement of the different subtypes in mortality. Methods: This was a descriptive longitudinal retrospective study developed in three tertiary hospitals in Spain. Among all patients admitted with a pulmonary aspergillosis diagnosis, we selected those who fulfilled the criteria for chronic aspergillosis according to the criteria of Denning, excluding those with a haematological disorder. Results: Among 409 inpatients recorded as having a pulmonary aspergillosis infection, only 76 (18.5%) fulfilled the criteria for CPA, with an estimated incidence of 0.67 cases/100,000 inhabitants/year. The subtypes detected were subacute invasive aspergillosis (SAIA) in 33 (43.4%) patients, simple aspergilloma (SA) in 25 (32.9%) patients, cavitary chronic aspergillosis (CCPA) in 13 (17.1%) patients, and chronic fibrosis (CFPA) in five (6.5%) patients. The overall three-month mortality rate was 23%, which was higher in SAIA patients. The predictors of early mortality were age > 65 years (OR 3.0 CI 95 1.0–9.5 p = 0.043) and the SAIA subtype vs. other subtypes (OR 3.1 CI 95 1.0–9.5 p = 0.042). Conclusions: The incidence rate estimated was inferior to that previously reported. The three-month mortality in patients with CPA was high, with older age and the SAIA subtype being the variable independent predictors of a worse prognosis.
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Nakatsugawa, Kohei, Hiroshi Kurosaka, Toshihiro Inubushi, Gozo Aoyama, Yukako Isogai, Yu Usami, Satoru Toyosawa, and Takashi Yamashiro. "Stage- and tissue-specific effect of cyclophosphamide during tooth development." European Journal of Orthodontics 41, no. 5 (February 2, 2019): 519–30. http://dx.doi.org/10.1093/ejo/cjz002.

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Summary Objective The aim of this study was to investigate the toxic effect of cyclophosphamide (CPA) in the development of rodent molars. Methods CPA was administered intraperitoneally in postnatal mice between Day 1 and Day 10, and the morphological phenotype was evaluated at Day 26 using micro-computed tomography and histological analysis, including cell proliferation and cell death analyses. Results M3 molars of the mice who received 100 mg/kg CPA treatment at Day 6 or M2 molars who received treatment at Day 1 resulted in tooth agenesis or marked hypoplasia. Histological observation demonstrated that CPA treatment at Day 6 resulted in shrinkage of the M3 tooth germs, with a significant reduction in the proliferation of apoptotic cells. Conversely, CPA exposure at Day 2, which occurs at around the bud stage of M3, resulted in crown and root hypoplasia, with reduced numbers of cusp and root. In addition, CPA exposure at Day 10, which is the late bell stage of M3, induced root shortening; however, it did not affect crown morphogenesis. Limitations The timing of CPA administration is limited to after birth. Therefore, its effect during the early stages of M1 and M2 could not be investigated. Conclusion Defective phenotypes were evident in both crown and roots due to the effect of CPA. Interestingly, the severity of the phenotypes was associated with the developmental stages of the tooth germs at the time of CPA administration. The cap/early bell stage is the most susceptive timing for tooth agenesis, whereas the late bell stage is predominantly affected in terms of root formation by CPA administration.
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Rauf, Akeem, Oyelade Akintoye, Ebere Chukwuemeka, and Israel Okolo. "Compressive and flexural strength of cement mortar blended with cassava peel ash and high-range water-reducing (superplasticizing) admixtures." Engineering Today, no. 00 (2024): 34. http://dx.doi.org/10.5937/engtoday2400011r.

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This paper presents the outcome of an experiment carried out by using cassava peel ash (CPA) of varying quantities to partially replace cement in mortar mix and the influence of adding superplasticizer in the mortar mix is further investigated. The experiment was carried out by partially replacing CPA in the range of 0 to 25 percent by weight of cement at 5% intervals. A water binder ratio (w/b) of 0.5 and superplasticizer dosage of 1.5l/100kg were used to produce the blended mortar of mix 1:3. The samples were cured and tested for compression and flexure at 7, 28, and 90 days after demolding. The results of the first experiment confirmed the suitability of the cassava peel ash (CPA) at not more than 15% replacement with cement for mortar and concrete works. In the second experiment, the superplasticizer has a linear relationship with the conventional mortar while the blended cement-cassava peel ash (CCPA) mortar retarded in strength at an early stage. However, 5% CPA mortar with superplasticizer gained 52 percent strength from 7 days to 28 days of the test. In addition, at the 90-day test, 5% CPA mortar with superplasticizer has almost an equivalent strength (96%) of the conventional mortar with superplasticizer. The flexural strength for blended CCPA mortar of 5-15% showed an acceptable value with that of mortar with a superplasticizer. Generally, the addition of admixture to the blended CCPA mortar showed a different trend compared to the conventional mortar.
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Uzunhan, Yurdagül, Hilario Nunes, Florence Jeny, Maxime Lacroix, Sophie Brun, Pierre-Yves Brillet, Emmanuel Martinod, et al. "Chronic pulmonary aspergillosis complicating sarcoidosis." European Respiratory Journal 49, no. 6 (June 2017): 1602396. http://dx.doi.org/10.1183/13993003.02396-2016.

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Chronic pulmonary aspergillosis (CPA) complicating sarcoidosis (SA) is associated with high mortality, and there is a lack of clarity regarding the relative contributions of SA or CPA.This was a retrospective single-centre study on CPA-SA.In total, 65 patients (44 men), aged 41.4±13.5 and 48.3±11.9 years at the time of SA and CPA diagnoses, respectively, were included between 1980 and 2015. Of these, 64 had fibrocystic SA, most often advanced, with composite physiological index (CPI) >40 (65% of patients) and pulmonary hypertension (PH) (31%), and 41 patients (63%) were treated for SA (corticosteroids or immunosuppressive drugs). Chronic cavitary pulmonary aspergillosis (CCPA) was the most frequent CPA pattern. Regarding treatment, 55 patients required long-term antifungals, 14 interventional radiology, 11 resection surgery and two transplantation. Nearly half of the patients (27; 41.5%) died (mean age 55.8 years); 73% of the patients achieved 5-year survival and 61% 10-year survival. Death most often resulted from advanced SA and rarely from haemoptysis. CPI, fibrosis extent and PH predicted survival. Comparison with paired healthy controls without CPA did not show any difference in survival, but a higher percentage of patients had high-risk mould exposure.CPA occurs in advanced pulmonary SA. CPA-SA is associated with high mortality due to the underlying advanced SA rather than to the CPA. CPI, fibrosis extent and PH best predict outcome.
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Tesis sobre el tema "CPA"

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Fernandes, Gilson. "Rede local de processadores de uma CPA-T." [s.n.], 1992. http://repositorio.unicamp.br/jspui/handle/REPOSIP/261556.

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Orientador: Michel Daoud Yacoub<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Eletrica<br>Made available in DSpace on 2018-07-15T20:24:07Z (GMT). No. of bitstreams: 1 Fernandes_Gilson_M.pdf: 16055731 bytes, checksum: dc376ba382f4dd9581ecf4ca2e91191f (MD5) Previous issue date: 1992<br>Resumo:Devido a redução nos custos dos processadores, causada pela evolução tecnológica, ocorreu uma revolução nos sistemas de controle e de processamento. Os sistemas de controle que tradicionalmente eram quase que exclusivamente centralizados, passaram a ser preteridos em função dos sistemas distribuídos. Os sistemas distribuídos propiciam uma capacidade de processamento ampliável, teoricamente infinita, pela agregação de novas unidades de processamento, além de prover um nível de confiabilidade superior ao dos sistemas centralizados convencionais. O propósito desta tese é descrever a arquitetura e a implementação de uma rede local de processadores particular que caracteriza um sistema distribuído. O objetivo imediato deste desenvolvimento foi servir como suporte ao controle de uma central CPA-T (central temporal com controle por programa armazenado) de grande porte (Sistema TRÓPICO RA). Como resultado obteve-se uma estrutura de controle que atendeu a todos os requisitos especificados. Além disso, a sua flexibilidade é tal que a mesma solução permite ser utilizada em outras aplicações onde seja necessário um sistema de comunicação entre processadores com características como alta performance, modularidade, confiabilidade, com a vantagem de utilizar-se um reduzido número de componentes de fácil aquisição no mercado<br>Abstract: Not informed.<br>Mestrado
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Ferreira, Ana Rute Marques. "Modelling the carbon dioxide solubility with CPA EOS." Master's thesis, Universidade de Aveiro, 2009. http://hdl.handle.net/10773/3116.

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Mestrado em Engenharia Química<br>As emissões de dióxido de carbono têm hoje uma grande importância na indústria de engenharia química, pelo que a sua captura e armazenamento são uma importante área de investigação. Os líquidos iónicos têm sido estudados como solventes (“green solvents”) para a separação de gases e captura de dióxido de carbono. Os líquidos iónicos são uma nova classe de solventes orgânicos, que devido aos seus catiões orgânicos assimétricos e aos aniões inorgânicos, não podem constituir uma estrutura cristalina, permanecendo assim no estado líquido à temperatura ambiente ou temperaturas próximas desta. Estes compostos apresentam uma vasta gama de propriedades interessantes, tais como a alta estabilidade térmica; o estado líquido numa grande amplitude térmica; a boa solvatação, tanto para compostos polares como não polares; e uma das mais interessantes, colocando-os como uma alternativa viável para substituir os solventes orgânicos voláteis, a sua pressão de vapor desprezável. Outra grande vantagem destes solventes "neotéricos" é a possibilidade de modelar as suas propriedades, através da infinita combinação de catiões e aniões, permitindo desenhar os líquidos iónicos de acordo com os objectivos específicos de uma operação particular melhorando o seu desempenho. Já foram aplicadas várias equações de estado para descrever a solubilidade do dióxido de carbono nos líquidos iónicos (equilíbrio líquidovapor), tais como a PC-SAFT, soft-SAFT, Peng-Robinson, Krichevsky- Kasarnovsky, entre outras equações de estado. Neste trabalho, dados experimentais para o equilíbrio líquido-vapor do sistema de dióxido de carbono + 1-alquil-3-metilimidazólio bis(trifluorometilsulfonil)imida foram modelados pela primeira vez com a equação do estado Cubic Plus Association (CPA EoS), em que os parâmetros da equação são obtidos através do ajuste de dados experimentais de pressão de vapor e densidade. Com o objectivo de estudar a solubilidade do dióxido de carbono noutros compostos, foram também medidos os equilíbrios líquidovapor dos sistemas dióxido de carbono + dissulfureto de carbono e dióxido de carbono + tetraclorometano, numa célula de alta pressão, e os dados experimentais obtidos foram igualmente modelados com a CPA EoS. A equação de estado CPA já demonstrou ser uma ferramenta termodinamicamente flexível tendo descrito correctamente o equilíbrio líquidovapor de misturas contendo componentes associativos e não associativos distribuídos por diferentes fases fluidas. Mostra-se que este modelo permite uma boa descrição dos dados experimentais disponíveis. ABSTRACT: Carbon dioxide emissions have today a great importance in the chemical engineering industry, so its capture and storage are an important field of research. Ionic liquids have been studied as green solvents in gases separation and for carbon dioxide capture. Ionic liquids are a new class of organic solvents that due to their asymmetric organic cations and organic or inorganic anions cannot form an ordered crystal and therefore remain liquid at or near room temperature. These compounds present a wide range of interesting properties, such as high thermal stability, large liquid temperature range, good solvation both for polar and non polar compounds, and one of the most interesting, putting them as a viable and ambient friendly alternative to replace the volatile organic solvents, is their negligible vapor pressure. Other major advantage of these “neoteric” solvents is the possibility of fine tune their properties through the endless combination of cations and anions. This designer characteristic allows one to build task-specific ionic liquids that have an enhanced performance for specific operations. Several equations of state have been applied to describe the carbon dioxide solubility in ionic liquids (vapor-liquid equilibrium) such PC-SAFT, soft- SAFT, Peng-Robinson EoS, Krichevsky–Kasarnovsky EoS, among others. In this work, the experimental vapour-liquid equilibrium data of the systems carbon dioxide + 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl) imide ionic liquids were modelled for the first time with the Cubic plus Association Equation of State (CPA EoS) with the EOS parameters fitted to vapor pressure and densities of the ionic liquids. In addition, it was used a high pressure cell to measure the vapour-liquid equilibrium of the binary systems carbon dioxide + carbon disulphide and carbon dioxide + carbon tetrachloride and the experimental data obtained were also modelled with the CPA EoS. The CPA EoS had already demonstrated to be a flexible thermodynamic tool for correctly modelling the phase equilibrium of mixtures containing both associative and non-associative components distributed by different fluid phases. It is shown that this model allows for a very good description of the experimental data available.
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Vallario, Charissa. "The CPA exam : the old and the new /." Staten Island, N.Y. : [s.n.], 2004. http://library.wagner.edu/theses/business/2004/thesis_bus_2004_valla_cpa.pdf.

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Hazera, Christophe. "NOPCPA ultracourt pompé par CPA fibré haute cadence." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0094/document.

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Ces dernières années, le développement des lasers femtosecondes s’est massivement orienté vers des sources à fortepuissance moyenne pour des applications autant scientifiques - par exemple la génération d’impulsions XUV - qu’industrielles. Cettethèse a consisté à développer une source laser permettant d’amplifier des impulsions ultra-brèves à très haute cadence par un laserà fibre avec d’un côté le développement d’un laser de pompe femtoseconde fibré (&lt;600fs) à haute cadence (100kHz), et de fortepuissance (50W) et de l’autre des amplificateurs paramétriques optiques ultrabrefs (&lt;10fs) pompés par cette même source. Pour cela,au sein d’une architecture à dérive de fréquence de fort étirement (2ns), nous avons exploité les propriétés des fibres photoniques à trèsgros coeur dopé à l’Ytterbium qui, pour approcher des énergies proches de 1mJ, nécessitent d’effectuer des études d’endommagement etde préparation des fibres. Nous avons alors pu démontrer une puissance maximale de 90W mais d’excellents résultats ont été établis dansun régime stable et robuste pour lequel ce laser délivre une puissance de 60W avec des impulsions de durées inférieures à 400fs. Aprèsdoublage en fréquence, ce laser a permis alors d’amplifier en deux étages dans des cristaux de BBO des bandes spectrales supérieuresà 300nm centrées autour de 800 nm avec une énergie par impulsion de 19[mu] J (1.9W). Avec un système d’étirement et de compressionbasé sur la combinaison de lames de silice et de miroirs à dérive de fréquence, ces impulsions ont pu atteindre une durée finale de 9.7fs.Ainsi, ces deux sources permettent d’ouvrir la voie à de vastes champs d’investigation en physique moléculaire et atomique<br>In recent years, the development of femtosecond lasers has been heavily oriented towards high average power sources forboth scientific experiments - such as XUV pulses generation - as well as for industrial applications. This work has been devoted to developa laser source able to amplify ultra-short pulses at a very high repetition rate. In one hand, we develop a high average power (50W)pump laser based on a Fiber Chirped Pulse Amplification (FCPA) technology delivering 400 fs pulses at a high repetition rate (100kHz).In the other hand, a multistage ultrafast optical parametric amplifiers (&lt;10fs) pumped by this source has been then implemented. Toachieve this, we took the benefits of the Ytterbium-doped large-core photonics fibre’s properties in order to approach energies closeto 1mJ. Even in a highly stretched chirped pulse architecture (2ns), using this kind of technology, required to perform studies overdamage and preparation processes of fibers. Thereby, we demonstrated a maximum output power of 90W, but excellent results havebeen obtained in a stable and robust regime in which this laser delivers 60W with pulse durations shorter than 400fs. After frequencydoubling, this laser was sent as a pump into a two-stages - non collinear parametric amplifier made with BBO crystals and a spectrumdelivered a by a CEP-Stable-6fs Ti :sa oscillator has been amplified around 800nm over a spectral bandwidth larger than 300nm witha pulse energy of 19[mu] J (1.9W). By using a stretching and compression scheme based on the combination of silica wedges and chirpedmirrors, the final pulses have been then recompressed down to 9.7fs. These laser systems can be now used to pave the way for vast fieldsof investigation in molecular and atomic physics
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Freeman, Michelle S. "The CPA Exam Is Changing: Are Professors Ready?" Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/5781.

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Kent, Lauren Jane. "The Consumer Protection Act (CPA) and conflict of laws: does the CPA provide mandatory minimum protection in an international commercial transaction?" Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/12899.

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Goodchild, David Joseph. "The determinants of organisational performance in parts of the local British public services using CPA and CAA." Thesis, Teesside University, 2015. http://hdl.handle.net/10149/613549.

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The research investigated the factors that are associated with organisational performance in British local public services using the national assessment frameworks of Comprehensive Performance Assessment (CPA) and Comprehensive Area Assessment (CAA). Performance measurement was said by Behn (1995) to be one of the big questions of public management and the literature demonstrates this remains the case. More generally performance management has been the subject of a large number of studies, many in the private sector, that often consider a narrow spectrum of explanatory factors. This research is unusual in studying a relatively large number of possible explanations of performance using three different methods of inquiry: longitudinal questionnaire surveys of four types of local public service organisations, a content analysis of strategic documents and the use of organisational profiles regarding the post bureaucratic construct (Kernaghan, 2000). The research relied on the CPA and CAA results to provide an independent assessment of organisational performance; such data is not usually available for public services. CPA has been found to have driven up local government performance (Boyne, James and John et al, 2010) and therefore its use is very appropriate. The analysis used correlation to identify the significant (p<0.05) criteria which were then put through a principal component analysis (PCA). This resulted in the identification of 11 summary factors with the strongest five being Strategy, Performance management, Human resources, Culture and Engagement. Factors of lesser importance are Resources, Leadership, Reputation and Innovation. The term ‘summary factors’ has been used to denote that within each of these there are potentially a number of parts. The research can be used practically by organisations, to improve, by comparing their results on the questionnaire with the criteria associated with high organisational performance. Further, the summary factors provide confidence regarding what may be the most critical areas to be addressed.
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Oliveira, Vera Lúcia Henriques de. "Modelling the aqueous solubility of PAHs with CPA EoS." Master's thesis, Universidade de Aveiro, 2008. http://hdl.handle.net/10773/3019.

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Mestrado em Engenharia Química<br>Os hidrocarbonetos aromáticos policíclicos (PAHs) constituem uma família de compostos caracterizada por possuírem dois ou mais anéis aromáticos condensados. São no geral referenciados de contaminantes ambientais porque estão associados à combustão incompleta de materiais orgânicos, como por exemplo, a queima de combustíveis fosseis, incineração de resíduos e derrames de petróleo. O estudo da solubilidade destes compostos em misturas aquosas é de grande importância, devido ao impacto que estes compostos têm na saúde pública e no meio ambiente, dado as suas propriedades cancerígenas. Neste trabalho, a capacidade da equação de estado CPA para modelar a solubilidade em meio aquoso de vários PAHs numa ampla gama de temperatura, foi avaliada. Esta equação de estado combina o termo Soave-Redlich-Kwong (SRK) para descrever as interações físicas com a contribuição de associação proposta por Wertheim, também usada em outras equações de estado, tais como as diferentes versões da SAFT. A CPA EoS já foi aplicada com sucesso a sistemas aquosos com alcanos, compostos aromáticos e álcoois. Os resultados obtidos são muito próximos dos valores encontrados na literatura, sugerindo que a CPA EoS é um modelo adequado para correlacionar soluções aquosas de moléculas complexas de poluentes orgânicos. ABSTRACT: The polycyclic aromatic hydrocarbons (PAHs) are a family of compounds characterized by having two or more aromatic rings condensed. They are referenced in general because they are environmental contaminants associated with the incomplete combustion of organic materials, such as the burning of fossil fuels and incineration of waste, and oil spills. The solubility of these xenobiotics in aqueous mixtures must be monitored due to their impact on public health and the environment, because of their carcinogenic properties and their ubiquity in the environment. In this work, the ability of the Cubic-plus-Association equation of state (CPA EoS) for modelling the aqueous solubility of several PAHs in a wide temperature range was evaluated. This equation of state combines the Soave-Redlich-Kwong (SRK) EoS for describing the physical interactions with the association contribution proposed by Wertheim, also used in other associating equations of state, such as the different versions of SAFT. The CPA EoS had already been successfully applied to aqueous systems with alkanes, aromatics and alcohols. The results obtained are in very close agreement with the literature data, suggesting that the CPA EoS is an adequate model for correlating aqueous solutions of complex molecules of organic pollutants.
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Freeman, Michelle S. "The CPA Exam is Changing: Are the Professors Ready?" Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/5772.

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Accounting professors will now be accountable for teaching their students to think critically, analyze, and evaluate information. The pressure to change accounting higher education cannot be ignored with the new version of the CPA exam, released in April 2017, which now tests analysis and evaluation skills. Have the professors made the changes in their classrooms that will help their students to be successful with this format of questioning? This research seeks to find whether professors have indeed embraced pedagogy that will enhance students’ ability to develop higher order thinking skills. The study begins by explaining changes to the CPA exam. The study provides literature review of the accounting education process, traditional methods of teaching accounting, suggested methods of teaching accounting for enhancement of critical thinking, and identified reasons for resistance to changing teaching methods. The survey is designed to identify current teaching methods in accounting classrooms. The survey seeks to discover what methods are being used to develop higher order thinking skills. The results show that lecture and demonstration of problems are still the predominant method of instruction in accounting classrooms, and these methods are not typically endorsed by research in terms of developing critical thinking, analysis and evaluation skills.
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Freeman, Michelle S., and Mark Steadman. "Getting Them There: Removing Barriers to the CPA License." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/5775.

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Article Excerpt: An intelligent student chooses to major in accounting. She persists through fraduation with a couble major in accounting and math and meets the 150-hour minimum education requirements…..
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Libros sobre el tema "CPA"

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Carmichael, Bobby J. CPA review. Cincinnati: South-Western College Pub., 1995.

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Longo, Susan C. CPA review. Cincinnati: South-Western College Pub., 1995.

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A, Hillison William, Irwin Grady M, and Kustanovich Michael, eds. CPA review. 2nd ed. Gainesville, Fla: Gleim Publications, 2015.

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Gleim, Irvin N. CPA review. 2nd ed. Gainesville, Fla: Gleim Pub., 2007.

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Klammer, Thomas P. CPA review. Cincinnati: South-Western College Pub., 1995.

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Kaplan Educational Centers (Firm : New York, N.Y.), ed. CPA workbook. New York, NY: Simon & Schuster, 1997.

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Roszkowski, Mark E. Business law for the CPA candidate: CPA problems. New York: HarperCollins, 1992.

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Gleim, Irvin N. CPA review: Regulation. 2nd ed. Gainesville, Fla: Gleim Pub., 2008.

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Gleim, Irvin N. CPA review: Financial. 2nd ed. Gainesville, Fla: Gleim Pub., 2009.

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Rigos, James J. CPA exam review. New York: ARCO, 1989.

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Capítulos de libros sobre el tema "CPA"

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Midyett, F. Allan, and Suresh K. Mukherji. "CPA Meningioma." In Skull Base Imaging, 61–65. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-46447-9_10.

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Saw, Sutaip L. C. "Multiclass CPA." In Introduction to Classifier Performance Analysis with R, 113–46. Boca Raton: Chapman and Hall/CRC, 2024. http://dx.doi.org/10.1201/9781003518679-5.

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Midyett, F. Allan, and Suresh K. Mukherji. "CPA Arachnoid Cyst." In Skull Base Imaging, 75–78. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-46447-9_12.

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Anastassakis, Konstantinos. "Cyproterone Acetate (CPA)." In Androgenetic Alopecia From A to Z, 115–20. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08057-9_7.

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Domański, Paweł D. "CPA Industrial Applications." In Studies in Systems, Decision and Control, 345–57. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-23593-2_15.

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Kitagawa, Fuyuki, and Takahiro Matsuda. "CPA-to-CCA Transformation for KDM Security." In Theory of Cryptography, 118–48. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-36033-7_5.

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Leeson, Will, and Matthew B. Dwyer. "Graves-CPA: A Graph-Attention Verifier Selector (Competition Contribution)." In Tools and Algorithms for the Construction and Analysis of Systems, 440–45. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-99527-0_28.

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AbstractGraves-CPA is a verification tool which uses algorithm selection to decide an ordering of underlying verifiers to most effectively verify a given program. Graves-CPA represents programs using an amalgam of traditional program graph representations and uses state-of-the-art graph neural network techniques to dynamically decide how to run a set of verification techniques. The Graves technique is implementation agnostic, but it’s competition submission, Graves-CPA, is built using several CPAchecker configurations as its underlying verifiers.
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Beyer, Dirk, Thomas Lemberger, and Henrik Wachowitz. "CPA-Daemon: Mitigating Tool Restarts for Java-Based Verifiers." In Lecture Notes in Computer Science, 158–73. Cham: Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-78750-8_8.

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Abstract We present CPA-Daemon, a microservice for continuous software verification of C code. CPA-Daemon provides full access to the verifier CPAchecker, but adds a clear network interface based on gRPC that abstracts from three different modes of execution: (1) running CPAchecker in a separate JVM, (2) running CPAchecker as a native executable compiled with GraalVM, and (3) running CPAchecker in a shared, continuously-running JVM. The last two are novel execution modes that greatly improve the response time of verification in different verification scenarios and enable the seamless integration of CPAchecker as an engine in other verification tooling. Our comparative evaluation shows that CPA-Daemon reduces the response time on small verification tasks down to 17 %, and that it can reduce the response time of existing cooperative verification techniques down to 70 %. While our implementation focuses on CPAchecker, the conceptual ideas are of general nature and can serve as a solution for other verification tools that face similar JVM-specific issues. CPA-Daemon is open source and available at https://gitlab.com/sosy-lab/software/cpa-daemon.
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Turek, Ilja, Václav Drchal, Josef Kudrnovský, Mojmír Šob, and Peter Weinberger. "Coherent Potential Approximation (CPA)." In Electronic Structure of Disordered Alloys, Surfaces and Interfaces, 113–35. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-6255-9_4.

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Hofmann, Robin, Leonie Ahrendts, and Rolf Ernst. "CPA: Compositional Performance Analysis." In Handbook of Hardware/Software Codesign, 721–51. Dordrecht: Springer Netherlands, 2017. http://dx.doi.org/10.1007/978-94-017-7267-9_24.

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Actas de conferencias sobre el tema "CPA"

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Boulanger, Vincent, Michel Olivier, Alexandre Chevrette, François Trépanier, and Michel Piché. "CPA-Ready Femtosecond Oscillator at 1 MHz." In CLEO: Applications and Technology, JTh5D.7. Washington, D.C.: Optica Publishing Group, 2024. http://dx.doi.org/10.1364/cleo_at.2024.jth5d.7.

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We present a versatile all-fiber oscillator generating stretched pulses (&gt; 100 ps) at a repetition rate of 1 MHz to seed compact CPA systems at 1030 nm. It generates 60-nJ pulses compressible to sub-300 fs.
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Deng, Zhuohao, Linwei Yao, Zhuohao Ning, Yiyuan Cheng, Kuan Li, and Jianping Yin. "CPA-UNet: nnUNet-Based Local Pyramid Aggregation Network." In 2024 2nd International Conference on Computer, Vision and Intelligent Technology (ICCVIT), 1–6. IEEE, 2024. https://doi.org/10.1109/iccvit63928.2024.10872489.

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Li, Jiajie, and Warren J. Gross. "A Layered CPA Decoder for Reed-Muller Codes." In 2024 58th Asilomar Conference on Signals, Systems, and Computers, 985–89. IEEE, 2024. https://doi.org/10.1109/ieeeconf60004.2024.10942623.

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CAVALCANTI, EDILZA RAKEL NÓBREGA, TALITA MIRANDA DE SOUSA, ADRIANO ELÍSIO DE FIGUEIREDO LOPES LUCENA, Osires De Medeiros Melo Neto, and MARIA INGRIDY LACERDA DINIZ. "UTILIZAÇÃO DO COMPACTADOR GIRATÓRIO SUPERPAVE® (CGS) NA DOSAGEM DE MISTURAS ASFÁLTICAS DO TIPO CAMADA POROSA DE ATRITO (CPA)." In Anais da 49ª Reunião Anual de Pavimentação - RAPv, 268–79. Recife, Brasil: Even3, 2024. http://dx.doi.org/10.29327/1430212.49-25.

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No Brasil, país predominantemente rodoviário, tem-se motivado a busca por métodos de pavimentação que ofereçam conforto e segurança aos usuários garantindo entre outras características, uma boa aderência pneu-pavimento e a drenagem eficaz das águas superficiais. Neste contexto, surgem as Camadas Porosas de Atrito (CPA), uma tecnologia utilizada como revestimento de pavimentos, e que tem por característica o elevado índice de vazios, entre 18 e 25%. A finalidade dessa pesquisa foi contribuir nas investigações sobre a viabilidade do uso do compactador giratório Superpave (CGS) na dosagem da CPA. Desta forma, objetivou-se implementar a compactação por amassamento, que simula mais fielmente a compactação de campo, à realidade da dosagem brasileira para camadas porosas de atrito, que atualmente é feita por meio da metodologia Marshall. Avaliou-se os efeitos da compactação CGS na mistura CPA por meio de ensaios de caracterização volumétrica e mecânica, sendo eles: volume de vazios, vazios comunicantes, desgaste cântabro, resistência à tração, escorrimento, módulo de resiliência e dano por umidade induzida. Para isto, foram realizadas compactações no CGS de misturas asfálticas com cinco teores de ligante distintos, onde o teor de projeto definido foi de 4,5% de ligante para a CPA. Os resultados encontrados estão dentro dos limites estabelecidos pelas normas DNIT-ES 386 e ASTM D7064, apontando a viabilidade do uso da compactação CGS em misturas asfálticas tipo CPA, dosadas de acordo com os parâmetros estabelecidos pela norma brasileira, acrescentando à metodologia nacional, às vantagens da compactação por amassamento.
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Besson, Frédéric. "CPA beats ∞-CFA." In the 11th International Workshop. New York, New York, USA: ACM Press, 2009. http://dx.doi.org/10.1145/1557898.1557905.

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Zhang, Yue, Carlos Ruiz, Shubham Rohal, and Shijia Pan. "CPA." In HotMobile '23: The 24th International Workshop on Mobile Computing Systems and Applications. New York, NY, USA: ACM, 2023. http://dx.doi.org/10.1145/3572864.3580328.

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Park, Sinwook, Praveen Kunchala, Hyejin Moon, and Bumsoo Han. "High Throughput Characterization of Cryoprotective Agent Mixtures Using an EWOD-Based Digital Microfluidic Device." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19273.

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One of the most challenging issues in cryopreservation is to identify new and improved cryoprotective agents (CPAs) or CPA mixtures beyond widely used dimethyl sulfoxide (DMSO). In order to address this challenge, numerous combinations of CPA mixtures need to be prepared, characterized, and screened. The characterization includes thermal properties and phase change behavior during freezing and thawing. For an example, Han et al. [1] performed analysis of the phase change behavior and the thermal properties of phosphate buffers saline (PBS) with various chemical additives (CPAs, AFPs, excess salts) using a differential scanning calorimeter and a cryo-microscope. Considering the number of possible compositions and concentration of CPA mixtures, a high throughput (HTP) screening platform capable of preparing and characterizing array of CPA mixtures is highly desired.
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Kohler, Leonie, Borislav Nikolic, Rolf Ernst, and Marc Boyer. "Increasing Accuracy of Timing Models: From CPA to CPA+." In 2019 Design, Automation & Test in Europe Conference & Exhibition (DATE). IEEE, 2019. http://dx.doi.org/10.23919/date.2019.8714770.

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Abdellatif, Karim M., Damien Couroussé, Olivier Potin, and Philippe Jaillon. "Filtering-based CPA." In CS2 '17: Cryptography and Security in Computing Systems. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3031836.3031842.

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Shu, Zhiquan, Cifeng Fang, Xiaoming Zhou, and Dayong Gao. "Cryoprotective Agent (CPA) Removal With Dilution-Filtration Method and CPA Concentration Monitoring With Electrical Conductivity Measurements." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-36538.

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In cell/tissue cryopreservation, cryoprotective agents (CPAs) should be added before freezing and removed after thawing. Nowadays people mainly apply centrifugation for CPA removal, which may cause many problems. Meanwhile, a simple and cheap method for real-time monitoring of the residual CPA concentration during processing remains an unfilled need. In this work, a “dilution-filtration” system with hollow fiber dialyzer was implemented and approved to remove dimethyl sulfoxide (Me2SO) effectively. Compared to other methods (centrifugation and microfluidic approach), this one holds advantages of low time and labor consumption, low osmotic injury to the cells, high effectiveness, ease to control the final suspension volume and low risk of contamination. The “dilution-filtration” system can also be easily modified for CPA addition and cell suspension volume control (concentration or dilution of cell suspension). Meanwhile, a method of electrical conductivity (EC) measurement was applied to monitor the residual CPA concentration. The results showed EC measurements of waste solution can convey the CPA concentrations in cell suspension. This validates the feasibility of a safer and easier way to on-line and real-time monitoring of CPA concentration in cell suspension by measuring the EC of waste solution.
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Informes sobre el tema "CPA"

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Hawley, Adam. PR-015-17606-R03 Flow Conditioner Swirl Reduction Testing. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), May 2019. http://dx.doi.org/10.55274/r0011585.

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This project evaluated the relative performance of the CPA 50E, CPA 55E, and CPA 65E flow conditioners manufactured by Canada Pipeline Accessories (CPA). The flow conditioners were tested to determine their ability to reduce swirl in a natural gas flow and to compare the audible noise of the flow conditioners over a range of flow rates.
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G. Shvets, N. J. Fisch, A. Pukhov, and J. Meyer-ter-Vehn. Pulse compression in plasma: Generation of femtosecond pulses without CPA. Office of Scientific and Technical Information (OSTI), July 2000. http://dx.doi.org/10.2172/758641.

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Caton, Yi-Jiun S., and Christopher Roth. SCATHA/SC3 Data Processing and Cross-Calibration with LANL-GEO/CPA for AE9 Development. Fort Belvoir, VA: Defense Technical Information Center, February 2014. http://dx.doi.org/10.21236/ada604523.

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Stute, Petra, Susanne Theis, Argy Kolokythas, Marc von Gernler, Astrid Eicher, Elenva Pavicic, Linus Walker, and Sabrina Baumgartner. Systematic review on the influence of progestogens on the endometrium. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2023. http://dx.doi.org/10.37766/inplasy2023.6.0028.

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Review question / Objective: The objective of this systematic review is to summarize published data from randomized controlled trials regarding the influence of a combined menopausal hormone therapy on the endometrium with specific focus on endometrial hyperplasia and endometrial cancer incidence. Eligibility criteria: The following progestagens will be investigated: Norethisterone (acetate) = NET(A), Dienogest = DNG, Dydrogesterone = DYD, Micronized Progesterone = MP, Drospirenone = DRSP, Levonorgestrel = LNG, Cyproterone acetate = CPA, Medroxyprogesterone acetate = MPA, Chlormadinone acetate = CMAExogenously administered on oral, transdermal or vaginal route; duration of study at least 3 months; in humans.
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Beccali, Marco, Marina Bonomolo, Francesca Martorana, Ben Alex Baby, Marco Pellegrini, and Salvatore Vasta. Show Cases on System and Component Level & Adapted Components. IEA SHC Task 65, April 2024. http://dx.doi.org/10.18777/ieashc-task65-2024-0001.

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This document is the final report for joint activities A2, “Adapted components”, and B1, “Show cases on system and component level” of the IEA SHC Task 65, “Solar Cooling for the Sunbelt Regions. The first part of the report presents results from 32 investigated projects across 18 countries representing a range of 10 weather profiles such as the tropical wet and dry (Aw), hot desert (BWh), hot semi-arid (BSh), hot summer-Mediterranean (Csa), warmsummer Mediterranean (Csb), humid subtropic (Cfa), monsoon-influenced humid subtropical (Cwa), hot summer humid continental climate zones.
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Myint, P. C., Y. Hao, and A. Firoozabadi. The CPA Equation of State and an Activity Coefficient Model for Accurate Molar Enthalpy Calculations of Mixtures with Carbon Dioxide and Water/Brine. Office of Scientific and Technical Information (OSTI), March 2015. http://dx.doi.org/10.2172/1194030.

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Browdy, Craig, and Esther Lubzens. Cryopreservation of Penaeid Shrimp Embryos: Development of a Germplasm Cryo-Bank for Preservation of High Health and Genetically Improved Stocks. United States Department of Agriculture, August 2002. http://dx.doi.org/10.32747/2002.7695849.bard.

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The objectives of the project were to develop a successful protocol for cryopreservation of penaeid germ plasm in order to preserve a pathogen-free broodstock nucleus for commercial exploitation of marine shrimp in aquaculture. The critical parameters to be characterized in the project were: 1. Determination of chill sensitivity and chill tolerant embryonic stages, including a full description and time course study of embryonic developmental stages. 2. Development of protocols for loading and removal of cryoprotectant agents (CPAs) from embryos; determination of optimal concentrations and duration of loading. 3. Characterization of the toxicity of the selected CP As and 4. Establishing optimal cooling and thawing procedures. Studies were performed on two penaeid species: Litopenaeus vannamei (in the USA) and P. semisulcatus (in Israel). The effect of incubation temperature on embryonic development rate and hatching success was studied in L. vannamei, showing that spawns maybe maintained at temperatures ranging from 24°C to 30°C, without compromising hatchability. Embryonic development extends from 12 hr to 19 hr at 30°C and 24°C, respectively. Studies showed that advanced embryonic developmental stages were chill tolerant in the two studied species, but P. semisulcatus could better endure lower temperatures than L. vannamei. A large number of experiments were performed to determine the optimal CP As, their concentration and duration of loading. Permeating (e.g. glycerol, methanol, DMSO, 1,2- propanediol, ethylene glycol, glucose) and non-permeating CPAs (sucrose, PVP, polyethylene glycol) were tested and several combinations of permeating and non-permeating CP As, on fertilized eggs (embryos), nauplii and protozoeae. In general, nauplii tolerated higher CPA concentrations than eggs and nauplii were also more permeable to radiolabeled methanol. Chlorine treatment intended to remove the chitinous envelop from eggs, did not increase dramatically the permeation of radiolabled methanol into eggs. Cooling eggs, nauplii or protozoeae to cryogenic temperatures, by either vitrification or slow cooling protocols, did not result in full survival of thawed samples, despite exhaustive attempts testing various protocols and CP As. Results seemed more encouraging in freezing of nauplii in comparison to eggs or protozoeae. Successful preliminary results in cryopreservation of spermatozoa of P. vannamei, will facilitate preservation of genetic specific to some extent.
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Liaga, Emmaculate Asige. Towards Local Approaches and Inclusive Peacebuilding in South Sudan. RESOLVE Network, October 2021. http://dx.doi.org/10.37805/pn2021.24.lpbi.

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The post-liberation peacebuilding in South Sudan, which largely drew from liberal peace theory, was employed between 2005 (after the signing of the Comprehensive Peace Agreement (CPA) and before the referendum, secession, and independence in 2011) and December 2013 (when it imploded into a civil conflict) and proved insufficient to sustain the fragile peace that briefly existed after the country’s secession from Sudan. After a protracted conflict lasting almost half a decade and the presence of multiple peace actors, the lack of a comprehensive and coordinated peacebuilding strategy proved detrimental. This failure is partly due to poor coordination between stakeholders and lack of local/domestic legitimacy, leading to insufficient peacebuilding and an aggravation of the 2013 conflict. Over the years, liberal peacebuilding strategies, which emphasize formal institution-building and statebuilding in fragile and conflict-affected environments, continue to produce mixed to poor results and fragile peace. This decline has resulted in the shifting of discourses and operations within peacebuilding, a paradigm shift that pays greater attention to localization and the local context in the conceptualization of peacebuilding objectives and strategies. This transformation promotes local ownership and inclusivity in peace processes and their dividends. The dialogue on inclusive peace has thus gained momentum, bearing a need to fully engage both states and societies in this process. The “local” in peacebuilding forms an important resource when solving root causes of conflicts, as in South Sudan, by improving awareness of the cultural and historical diversity in a given context.
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Cole, Christian, Gordon Milligan, Antony Chuter, Jillian Beggs, Judith Fisher, Blair Smith, and Lesley Colvin. How lived experience can inform and direct pain projects: Alleviate Pain Data Hub as a case study. University of Dundee, 2024. https://doi.org/10.20933/100001357.

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BACKGROUND: Chronic pain affects a large proportion of the general population – at least 34% of adults in the UK - and it has a huge impact on people’s lives as well as the workplace and health services, accounting for more than 75% of the years lived with disability. Despite this, chronic pain is poorly captured in clinical data which makes it difficult to identify appropriate patient cohorts especially for retrospective observational studies. A different model for pain-related projects is to include the patient voice directly into the team with the addition of funded patient members. Here we present our positive experiences from within the Alleviate Pain Data Hub. AIMS: To demonstrate how the patient voice is an intrinsic part of chronic pain research through the experience of the Alleviate Pain Data Hub and its pain community. To highlight the lived experience of people with chronic pain to inform the project and to respond to important issues. METHODS: Throughout the lifetime of the Alleviate project two patient representatives have been included as part of the core project team. Using their input, alongside the input of a wider Chronic Pain Advisory Group, a continuous theme of outputs was generated to inform current and future research. For example, in 2023, a chronic pain survey based on a set of questions developed and used by Chronic Pain Australia (CPA) in 2023 was adapted for the UK population. Ethics approval was gained by the University of Dundee, School of Medicine ethics committee. The survey was open for a month between 16th November – 15th December 2023 and was shared via social media by the Alleviate Data Hub, the Advanced Pain Discovery Platform (APDP), Pain UK and HDR UK, plus direct contact was made with various large organisations, trade unions and charities. The survey was open to all adults across the UK. RESULTS: The patient members of the team have been included throughout the project lifecycle and have been instrumental in delivering several of Alleviate’s outputs. Together with a public/patient involvement and engagement (PPIE) coordinator the patient members developed a recruitment strategy for the Alleviate pain community which includes 336 individuals. From this pool we recruited a panel of pain forum members who join in regular project meetings, PPIE specific events and have contributed to the direction taken in Alleviate. This includes the initiation of a collaboration between Alleviate, APDP, Pain UK and CPA on the reuse of the Australian survey in the UK. The questions covered general demographics of the participants and covered topics around an individual’s experience with pain and subsequent contact with health professionals, what research topics are important, and their emotional experiences relating to chronic pain research. 623 responses from across the UK four nations were received with a dominance of people living in England (71%), female (80%), with a median age of 53 and 9% from an ethnic minority background. Some key responses were that 75% of respondents felt ignored or dismissed by healthcare services and upto 44% were stigmatised by GPs or other health professionals. Further analysis will be presented covering aspects of the patient journey, management of their pain and views on most important research topics. CONCLUSIONS: Being able to include the knowledge and experience of those living with pain and act on their needs and/or requests highlighted how impactful partner patient partners can be. The patient voice is a powerful director and motivator within Alleviate which has instigated several activities that would not have otherwise occurred: 1) raised the importance of chronic pain; 2) produced instructive materials for the public and researchers; and 3) instigated new collaborations.
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Medof, M. E. Augmentation of Antitumor T-Cell Responses by Increasing APC T-Cell C5a/C3a-C5aR/C3aR Interactions. Fort Belvoir, VA: Defense Technical Information Center, March 2013. http://dx.doi.org/10.21236/ada585489.

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