Literatura académica sobre el tema "Convergent transcription"
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Artículos de revistas sobre el tema "Convergent transcription"
Hobson, David J., Wu Wei, Lars M. Steinmetz y Jesper Q. Svejstrup. "RNA Polymerase II Collision Interrupts Convergent Transcription". Molecular Cell 48, n.º 3 (noviembre de 2012): 365–74. http://dx.doi.org/10.1016/j.molcel.2012.08.027.
Texto completoGullerova, Monika y Nick J. Proudfoot. "Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells". Nature Structural & Molecular Biology 19, n.º 11 (30 de septiembre de 2012): 1193–201. http://dx.doi.org/10.1038/nsmb.2392.
Texto completoLin, Yunfu, Mei Leng, Ma Wan y John H. Wilson. "Convergent Transcription through a Long CAG Tract Destabilizes Repeats and Induces Apoptosis". Molecular and Cellular Biology 30, n.º 18 (20 de julio de 2010): 4435–51. http://dx.doi.org/10.1128/mcb.00332-10.
Texto completoInagaki, Soichi, Mayumi Takahashi, Kazuya Takashima, Satoyo Oya y Tetsuji Kakutani. "Chromatin-based mechanisms to coordinate convergent overlapping transcription". Nature Plants 7, n.º 3 (marzo de 2021): 295–302. http://dx.doi.org/10.1038/s41477-021-00868-3.
Texto completoDang, Yunkun, Liande Li, Wei Guo, Zhihong Xue y Yi Liu. "Convergent Transcription Induces Dynamic DNA Methylation at disiRNA Loci". PLoS Genetics 9, n.º 9 (5 de septiembre de 2013): e1003761. http://dx.doi.org/10.1371/journal.pgen.1003761.
Texto completoLin, William Y., Yunfu Lin y John H. Wilson. "Convergent transcription through microsatellite repeat tracts induces cell death". Molecular Biology Reports 41, n.º 9 (11 de julio de 2014): 5627–34. http://dx.doi.org/10.1007/s11033-014-3432-y.
Texto completoMarinov, Georgi K., Alexandro E. Trevino, Tingting Xiang, Anshul Kundaje, Arthur R. Grossman y William J. Greenleaf. "Transcription-dependent domain-scale three-dimensional genome organization in the dinoflagellate Breviolum minutum". Nature Genetics 53, n.º 5 (29 de abril de 2021): 613–17. http://dx.doi.org/10.1038/s41588-021-00848-5.
Texto completoEszterhas, Susan K., Eric E. Bouhassira, David I. K. Martin y Steven Fiering. "Transcriptional Interference by Independently Regulated Genes Occurs in Any Relative Arrangement of the Genes and Is Influenced by Chromosomal Integration Position". Molecular and Cellular Biology 22, n.º 2 (15 de enero de 2002): 469–79. http://dx.doi.org/10.1128/mcb.22.2.469-479.2002.
Texto completoCalero-Nieto, Fernando J., Andrew G. Bert y Peter N. Cockerill. "Transcription-dependent silencing of inducible convergent transgenes in transgenic mice". Epigenetics & Chromatin 3, n.º 1 (2010): 3. http://dx.doi.org/10.1186/1756-8935-3-3.
Texto completoChatterjee, A., C. M. Johnson, C. C. Shu, Y. N. Kaznessis, D. Ramkrishna, G. M. Dunny y W. S. Hu. "Convergent transcription confers a bistable switch in Enterococcus faecalis conjugation". Proceedings of the National Academy of Sciences 108, n.º 23 (23 de mayo de 2011): 9721–26. http://dx.doi.org/10.1073/pnas.1101569108.
Texto completoTesis sobre el tema "Convergent transcription"
Billingsley, Daniel Jeffrey. "Convergent transcription and nested gene models studied by AFM". Thesis, University of Leeds, 2012. http://etheses.whiterose.ac.uk/3149/.
Texto completoChammas, Oliver. "Concurrent DNA transcription from convergent and tandem promoters studied by atomic force microscopy". Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/15361/.
Texto completoCroniger, Colleen Marie. "Convergent transcription of the myosin heavy chain gene (Mhc) and transcriptional unit at chromosomal locus 36B (TU-36B) in Drosophila". Case Western Reserve University School of Graduate Studies / OhioLINK, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=case1059654256.
Texto completoDeb, Maharshi Krishna. "Generation of antisense RNAs at convergent gene loci in cells undergoing senescence". Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30274.
Texto completoCellular senescence represents one of the major fail-safe mechanisms that counteracts tumour development is defined as a state of irreversible cell cycle arrest as a consequence of stress response such as oncogenic challenge. Such cells undergoing Oncogene-induced Senescence (OIS) display profound alternation in their epigenome as their chromatin are largely decorated with prominent drivers of constitutive heterochromatin.Antisense RNA-mediated gene regulation has been attributed to play diverse roles in mediating various cellular processes and cell fates per-se. In yeast, histone variant H2A.Z cooperates with RNAi and heterochromatin machinery to regulate antisense transcription at convergent gene loci which can otherwise generate pervasive read-through transcripts owing to improper transcription termination. In mammals, whether such antisense transcripts (occurring by read-through transcription at convergent gene pairs) exist and how they are regulated remains unknown. Interestingly, the depletion of the human H2A.Z histone variant has been reported to induce cellular senescence. We thus wondered if the regulation of particular antisense transcripts at convergent gene pairs occurs in senescence, if their regulation by H2A.Z is conserved in mammals and, if so, if a functional significance can be attributed to these transcripts. To this end we took advantage of a well-established in-vitro OIS model. Briefly, we analysed genome wide strand specific RNA-seq analysis of cells undergoing Oncogene Induced Senescence. This led us to identify numerous convergent gene loci associated with accumulation of transcripts downstream of the designated transcription termination site in senescent cells, and extending to generate an antisense to the next gene located in the opposite strand of the convergent gene pair. We confirmed the RNA-seq data at two of such convergent loci. An RNAi based approach revealed that at least two of these transcripts are generated by transcriptional read-throughs. Hence we designated such pervasive transcripts as Senescence Triggered Antisense Read-through Transcripts (START). Importantly, we further found that the two STARTs for which we performed in depth studies repress the expression of the gene for which they are antisense. Finally, we demonstrate that the histone variant H2A.Z suppresses the accumulation of STARTs in proliferative cells. Since it also prevents senescence induction, this suggests that expression of START is important for cellular senescence. This has lead us to propose a model that human cells undergoing OIS are associated with loss of H2A.Z that leads to the wide spread accumulation of read-through transcripts owing to impaired termination control
Yi, Jia. "The Role of Convergent Transcription in Regulating Alternative Splicing : Targeted Epigenetic Modification via Repurposed CRISPR/Cas9 System and Its Impact on Alternative Splicing Modulation". Electronic Thesis or Diss., Sorbonne université, 2020. http://www.theses.fr/2020SORUS382.
Texto completoAlternative splicing of precursor RNA is a co-transcriptional process that affects the vast majority of human genes and contributes to protein diversity. Dysregulation of such process is implicated in various diseases, including tumorigenesis. However, the mechanisms regulating these processes were still to be characterized. In this study, we showed that perturbations of alternative splicing correlated with dysregulations of convergent transcription and DNA methylation. Convergent transcription could be generated between pairs of neighboring genes in opposite orientation, or between intragenic enhancers and their host gene. CENPO and ADCY3 was identified as a convergent transcription gene pair. We found, in a tumor progression model of breast cancer, that the splicing change of the ADCY3 variant exon22 correlated with an increase of its transcription that went against that of CENPO. By using targeted transcription repression system CRISPRi, we demonstrated that downregulating the transcription of CENPO could not reverse the alternative splicing alteration of ADCY3 in cancer cells (DCIS). An active intragenic enhancer was identified in the intron16 of CD44, at the downstream of its alternative exons. By using targeted transcription activation system CRISPRa, we showed that upregulating the transcription of CD44 could not alter the alternative splicing of CD44 in DCIS cells. These results suggest that convergent transcription modulation through changes of promoter activity does not alter the alternative splicing of ADCY3 and CD44 in DCIS cells. However, through replacing the intragenic enhancer by an inducible promoter, we found that intragenic transcription activation increased the inclusion level of several alternative exons of CD44 in HCT116 cells. This result suggested that local convergent transcription could have a direct impact on the alternative splicing of CD44. Furthermore, by using targeted DNA methylation system CRISPR/dCas9-DNMT3b, we showed that DNA methylation at variant exons could directly modify CD44 alternative splicing. This thesis work also explored the limitation and feasibility of studying alternative splicing with repurposed CRISPR systems
Omont, Nicolas Képès François. "La convergence des modularités structurelles et fonctionnelles des systèmes complexes". S. l. : Evry-Val d'Essonne, 2009. http://www.biblio.univ-evry.fr/theses/2008/2008EVRY0037.pdf.
Texto completoIvanova, Tsvetomira Georgieva 1978. "The DNA damage and the DNA synthesis checkpoints converge at the MBF transcription factor". Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/116932.
Texto completoBatlle, Ana. "Regulation of BCL6:p38 MAPK signalling and CTCF transcriptional regulation converge at exon 1". Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6093.
Texto completoDemagny, Hadrien. "Convergence des voies de signalisation wnt, fgf et tgf-beta au niveau des facteurs de transcription smad1 et smad4". Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066164/document.
Texto completoDuring my PhD I studied how cells receive and integrate multiple signals from the extracellular milieu. I focused on Smad proteins and my project can be divided into two parts. My first project was centered on the transcription factor Mad (Smad1) and its requirement for the BMP and Wg pathways. Using a combination of genetic and biochemistry experiments, we showed that Mad is required for Wg signaling both in Tcf reporter gene assays and in vivo in Drosophila. We found that the choice for Mad to transduce Dpp or Wg signals is controlled by C-terminal phosphorylations so that Mad binds to Pangolin and participates in Wg target genes transcription only when not phosphorylated at its C-terminus. This results in a competition between Dpp and Wg controlled by the phosphorylation state of Mad. My second project was focused on the tumor suppressor Smad4. When I first joined the lab, I identified three new potential GSK3 phosphorylation sites in Smad4 primary sequence. I used a home-made phospho-specific antibody to demonstrate that FGF or EGF stimulation trigger Erk-mediated phosphorylation of Smad4 which primes subsequent GSK3 phosphorylations. These phosphorylations regulate a transcription activation domain located in Smad4 linker region and generate a Wnt-regulated phosphodegron recognized by the E3 ligase beta-TrCP. This mechanism provides a means of integrating distinct pathways which would otherwise remain insulated, allowing cells to sense FGF and Wnt inputs and adapt TGF-beta outcome to their context. It provides a molecular explanation of the long-standing mystery of the “competence modifier” effect of Wnt on Nodal signals discovered 20 years ago
Demagny, Hadrien. "Convergence des voies de signalisation wnt, fgf et tgf-beta au niveau des facteurs de transcription smad1 et smad4". Electronic Thesis or Diss., Paris 6, 2014. http://www.theses.fr/2014PA066164.
Texto completoDuring my PhD I studied how cells receive and integrate multiple signals from the extracellular milieu. I focused on Smad proteins and my project can be divided into two parts. My first project was centered on the transcription factor Mad (Smad1) and its requirement for the BMP and Wg pathways. Using a combination of genetic and biochemistry experiments, we showed that Mad is required for Wg signaling both in Tcf reporter gene assays and in vivo in Drosophila. We found that the choice for Mad to transduce Dpp or Wg signals is controlled by C-terminal phosphorylations so that Mad binds to Pangolin and participates in Wg target genes transcription only when not phosphorylated at its C-terminus. This results in a competition between Dpp and Wg controlled by the phosphorylation state of Mad. My second project was focused on the tumor suppressor Smad4. When I first joined the lab, I identified three new potential GSK3 phosphorylation sites in Smad4 primary sequence. I used a home-made phospho-specific antibody to demonstrate that FGF or EGF stimulation trigger Erk-mediated phosphorylation of Smad4 which primes subsequent GSK3 phosphorylations. These phosphorylations regulate a transcription activation domain located in Smad4 linker region and generate a Wnt-regulated phosphodegron recognized by the E3 ligase beta-TrCP. This mechanism provides a means of integrating distinct pathways which would otherwise remain insulated, allowing cells to sense FGF and Wnt inputs and adapt TGF-beta outcome to their context. It provides a molecular explanation of the long-standing mystery of the “competence modifier” effect of Wnt on Nodal signals discovered 20 years ago
Libros sobre el tema "Convergent transcription"
Campione, Marina, Amelia Aranega y Diego Franco. Cardiac looping and laterality. Editado por José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso y Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0014.
Texto completoMiquerol, Lucile. Origin and development of the cardiac conduction system. Editado por José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso y Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0015.
Texto completoFiddes, Paul S. Charles Williams and C. S. Lewis. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780192845467.001.0001.
Texto completoCapítulos de libros sobre el tema "Convergent transcription"
Kwak, Sun-Dong y Moon-Soo Chang. "Development of Transcription Tools That Improved Safety and Convenience". En Convergence and Hybrid Information Technology, 294–301. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-32692-9_38.
Texto completoGiglio, Lorenzo. "Ancora su Boccaccio copista di Dante: (almeno) tre ‘redazioni’ della Vita nuova". En Intorno a Boccaccio / Boccaccio e dintorni 2020, 23–38. Florence: Firenze University Press, 2021. http://dx.doi.org/10.36253/978-88-5518-510-3.03.
Texto completoDwivedi, Nidhi, Vinay Kumar y Jitendra K. Thakur. "Convergence of Stress-Induced Hormone Signaling Pathways on a Transcriptional Co-Factor". En Mechanism of Plant Hormone Signaling under Stress, 285–317. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781118889022.ch28.
Texto completoSeligmann, Herve. "Mutation Patterns Due to Converging Mitochondrial Replication and Transcription Increase Lifespan, and Cause Growth Rate-Longevity Tradeoffs". En DNA Replication-Current Advances. InTech, 2011. http://dx.doi.org/10.5772/24319.
Texto completoEllison, Jay w. "SHOX and Dyschondrosteosis and Turner Syndrome". En Inborn Errors Of Development, 735–39. Oxford University PressNew York, NY, 2008. http://dx.doi.org/10.1093/oso/9780195306910.003.0077.
Texto completoActas de conferencias sobre el tema "Convergent transcription"
Sonawane, Dayaram, Manan Pathak y Venkat R. Subramanian. "Convergence rates for direct transcription of optimal control problems using Second Derivative Methods". En 2016 American Control Conference (ACC). IEEE, 2016. http://dx.doi.org/10.1109/acc.2016.7524918.
Texto completoBang, Jeong-Uk, Sang-Hun Kim y Oh-Wook Kwon. "Phoneme Set Extension Based on Jensen-Shannon Divergence for Broadcast News Transcription". En 2020 International Conference on Information and Communication Technology Convergence (ICTC). IEEE, 2020. http://dx.doi.org/10.1109/ictc49870.2020.9289468.
Texto completoSophea, Seng y Somnuk Phon-Amnuaisuk. "Determining a Suitable Desired Factors for Nonnegative Matrix Factorization in Polyphonic Music Transcription". En 2007 International Symposium on Information Technology Convergence (ISITC 2007). IEEE, 2007. http://dx.doi.org/10.1109/isitc.2007.50.
Texto completoYou, Yeonguk, Hyangrae Noh, Jaeeun Park, Yunsoo Kim, Yongjin KwaK y Yoonjoong Kim. "A development of a speech data transcription tool for building a spoken corpus". En 2018 International Conference on Information and Communication Technology Convergence (ICTC). IEEE, 2018. http://dx.doi.org/10.1109/ictc.2018.8539450.
Texto completoSunkel, Benjamin D., Dayong Wu, Xiangtao Liu, Zhenqing Ye, Victor Jin y Qianben Wang. "Abstract 1387: Convergent CREB1/FoxA1 transcriptional activity defines castration-resistant prostate cancer gene expression profile". En Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1387.
Texto completoKarneswaran, S. y L. T. Biegler. "Convergence rates for direct transcription of optimal control problems with final-time equality constraints using collocation at Radau points". En 2006 American Control Conference. IEEE, 2006. http://dx.doi.org/10.1109/acc.2006.1655348.
Texto completoBodin, Per, Kristian Lindqvist, David Seelbinder, Artemi Makarow, José Garrido, Alessandro Visintini, Marilena Di Carlo, Andrew Hyslop y Valentin Preda. "Attitude Guidance Using On-Board Optimisation". En ESA 12th International Conference on Guidance Navigation and Control and 9th International Conference on Astrodynamics Tools and Techniques. ESA, 2023. http://dx.doi.org/10.5270/esa-gnc-icatt-2023-113.
Texto completoCuiffo, Benjamin, Antoine Campagne, George W. Bell, Evan Lien, Manoj K. Bhasin, Odette Mariani, Anne Vincent-Salomon y Antoine Karnoub. "Abstract 173: Tumor proximal mesenchymal stem cells initiate a pro-metastatic microRNA regulatory network which acts via convergent targeting of the speech-associated transcriptional repressor FOXP2". En Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-173.
Texto completoGarg, Rachana, Jorge Blando, Carlos Perez, Martin Abba, Fernando Benavides y Marcelo Kazanietz. "Abstract LB-230: Oncogenic PKC epsilon and Pten loss converge on activating CXCL13 via atypical NF-κB transcriptional signaling in prostate cancer progression". En Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-lb-230.
Texto completoLinher-Melville, K., MG Nashed, R. Ungard, S. Haftchenary, PT Gunning y G. Singh. "Abstract P3-03-13: Chronic inhibition of signal transducer and activator of transcription 3/5 in treatment-resistant human breast cancer cell subtypes: Convergence on the reactive oxyten species/SUMOylation pathway and its effects on xCT expression and system xc-activity". En Abstracts: 2016 San Antonio Breast Cancer Symposium; December 6-10, 2016; San Antonio, Texas. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.sabcs16-p3-03-13.
Texto completoInformes sobre el tema "Convergent transcription"
Levy, Avraham A. y Virginia Walbot. Regulation of Transposable Element Activities during Plant Development. United States Department of Agriculture, agosto de 1992. http://dx.doi.org/10.32747/1992.7568091.bard.
Texto completoSamach, Alon, Douglas Cook y Jaime Kigel. Molecular mechanisms of plant reproductive adaptation to aridity gradients. United States Department of Agriculture, enero de 2008. http://dx.doi.org/10.32747/2008.7696513.bard.
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