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Literatura académica sobre el tema "Compartmentalized reactions"

Autor: Grafiati

Publicado: 25 de mayo de 2024

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Artículos de revistas sobre el tema "Compartmentalized reactions"

Rodier, Bradley J., Al de Leon, Christina Hemmingsen y Emily Pentzer. "Polymerizations in oil-in-oil emulsions using 2D nanoparticle surfactants". Polymer Chemistry 9, n.º 13 (2018): 1547–50. http://dx.doi.org/10.1039/c7py01819c.

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Simon, David, Franziska Obst, Sebastian Haefner, Toni Heroldt, Martin Peiter, Frank Simon, Andreas Richter, Brigitte Voit y Dietmar Appelhans. "Hydrogel/enzyme dots as adaptable tool for non-compartmentalized multi-enzymatic reactions in microfluidic devices". Reaction Chemistry & Engineering 4, n.º 1 (2019): 67–77. http://dx.doi.org/10.1039/c8re00180d.

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Huttanus, Herbert M. y Ryan S. Senger. "A synthetic biosensor to detect peroxisomal acetyl-CoA concentration for compartmentalized metabolic engineering". PeerJ 8 (8 de septiembre de 2020): e9805. http://dx.doi.org/10.7717/peerj.9805.

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Background Sub-cellular compartmentalization is used by cells to create favorable microenvironments for various metabolic reactions. These compartments concentrate enzymes, separate competing metabolic reactions, and isolate toxic intermediates. Such advantages have been recently harnessed by metabolic engineers to improve the production of various high-value chemicals via compartmentalized metabolic engineering. However, measuring sub-cellular concentrations of key metabolites represents a grand challenge for compartmentalized metabolic engineering. Methods To this end, we developed a synthetic biosensor to measure a key metabolite, acetyl-CoA, in a representative compartment of yeast, the peroxisome. This synthetic biosensor uses enzyme re-localization via PTS1 signal peptides to construct a metabolic pathway in the peroxisome which converts acetyl-CoA to polyhydroxybutyrate (PHB) via three enzymes. The PHB is then quantified by HPLC. Results The biosensor demonstrated the difference in relative peroxisomal acetyl-CoA availability under various culture conditions and was also applied to screening a library of single knockout yeast mutants. The screening identified several mutants with drastically reduced peroxisomal acetyl-CoA and one with potentially increased levels. We expect our synthetic biosensors can be widely used to investigate sub-cellular metabolism and facilitate the “design-build-test” cycle of compartmentalized metabolic engineering.

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Punyasu, Nattharat, Saowalak Kalapanulak y Treenut Saithong. "Development of a compartmentalized model for insight into the structured metabolic pathway of carbon metabolism in cassava leaves". APRIL 2019 13, (04) 2019 (20 de abril de 2019): 605–15. http://dx.doi.org/10.21475/ajcs.19.13.04.p1639.

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In silico metabolic modeling has enabled systematic study of complicated metabolic processes underlying phenotypes of organisms. Modeling of plant metabolism is often hampered by the network complexity and lack of adequate knowledge. The existing metabolic networks of cassava only cover broad metabolism and are not compartmentalized to truly represent metabolism in photosynthetic tissues. To address the aforementioned limitations and develop a robust metabolic network, physiological and genomic data derived from cassava and leaf models of Arabidopsis and rice were to extend the scope of the existing model. The proposed compartmentalized network of metabolism in photosynthetic tissues of cassava, ph-MeRecon (photosynthetic-Manihot esculenta Metabolic Pathway Reconstruction) was developed based on the information resulting of the comparative study of multiple model plants and cassava genome. The ph-MeRecon covers primary carbon metabolism and comprises 461 metabolites, 550 reactions, and 1,037 metabolic genes. Enzymatic genes on the network were validated using RNA-expression data, and the reactions and pathways were compartmentalized into cytoplasm, chloroplast, mitochondria, and peroxisome. To ensure network connectivity, metabolic gaps were filled using gap reactions obtained from literature and metabolic pathway omnibus. In addition, information on plant physiology, including photosynthetic light-dependent reactions, carboxylase and oxygenase activity of RuBisCO enzyme, and phosphoenolpyruvate carboxylase enzyme activity was incorporated into ph-MeRecon to mimic cellular metabolism in cassava leaves. Thus, ph-MeRecon offers a multi-level platform for system analysis of cellular mechanisms underlying phenotypes of interest in cassava. The ph-MeRecon metabolic model is available at http://bml.sbi.kmutt.ac.th/ph-MeRecon/.

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Kato, Shuzo, David Garenne, Vincent Noireaux y Yusuke T. Maeda. "Phase Separation and Protein Partitioning in Compartmentalized Cell-Free Expression Reactions". Biomacromolecules 22, n.º 8 (14 de julio de 2021): 3451–59. http://dx.doi.org/10.1021/acs.biomac.1c00546.

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Baier, Gerold y Sven Sahle. "Spatio-temporal patterns with hyperchaotic dynamics in diffusively coupled biochemical oscillators". Discrete Dynamics in Nature and Society 1, n.º 2 (1997): 161–67. http://dx.doi.org/10.1155/s1026022697000162.

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We present three examples how complex spatio-temporal patterns can be linked to hyperchaotic attractors in dynamical systems consisting of nonlinear biochemical oscillators coupled linearly with diffusion terms. The systems involved are: (a) a two-variable oscillator with two consecutive autocatalytic reactions derived from the Lotka–Volterra scheme; (b) a minimal two-variable oscillator with one first-order autocatalytic reaction; (c) a three-variable oscillator with first-order feedback lacking autocatalysis. The dynamics of a finite number of coupled biochemical oscillators may account for complex patterns in compartmentalized living systems like cells or tissue, and may be tested experimentally in coupled microreactors.

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Daddaoua, Abdelali, Tino Krell, Carlos Alfonso, Bertrand Morel y Juan-Luis Ramos. "Compartmentalized Glucose Metabolism in Pseudomonas putida Is Controlled by the PtxS Repressor". Journal of Bacteriology 192, n.º 17 (25 de junio de 2010): 4357–66. http://dx.doi.org/10.1128/jb.00520-10.

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ABSTRACT Metabolic flux analysis revealed that in Pseudomonas putida KT2440 about 50% of glucose taken up by the cells is channeled through the 2-ketogluconate peripheral pathway. This pathway is characterized by being compartmentalized in the cells. In fact, initial metabolism of glucose to 2-ketogluconate takes place in the periplasm through a set of reactions catalyzed by glucose dehydrogenase and gluconate dehydrogenase to yield 2-ketogluconate. This metabolite is subsequently transported to the cytoplasm, where two reactions are carried out, giving rise to 6-phosphogluconate, which enters the Entner-Doudoroff pathway. The genes for the periplasmic and cytoplasmic set of reactions are clustered in the host chromosome and grouped within two independent operons that are under the control of the PtxS regulator, which also modulates its own synthesis. Here, we show that although the two catabolic operons are induced in vivo by glucose, ketogluconate, and 2-ketogluconate, in vitro we found that only 2-ketogluconate binds to the regulator with an apparent KD (equilibrium dissociation constant) of 15 μM, as determined using isothermal titration calorimetry assays. PtxS is made of two domains, a helix-turn-helix DNA-binding domain located at the N terminus and a C-terminal domain that binds the effector. Differential scanning calorimetry assays revealed that PtxS unfolds via two events characterized by melting points of 48.1°C and 57.6°C and that, in the presence of 2-ketogluconate, the unfolding of the effector binding domain occurs at a higher temperature, providing further evidence for 2-ketogluconate-PtxS interactions. Purified PtxS is a dimer that binds to the target promoters with affinities in the range of 1 to 3 μM. Footprint analysis revealed that PtxS binds to an almost perfect palindrome that is present within the three promoters and whose consensus sequence is 5′-TGAAACCGGTTTCA-3′. This palindrome overlaps with the RNA polymerase binding site.

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Di Bernardo, Salvatore, Romana Fato y Giorgio Lenaz. "Redox Reactions in Lipid Membranes as a Model for Primordial Energy-Conserving Systems". International Astronomical Union Colloquium 161 (enero de 1997): 437–42. http://dx.doi.org/10.1017/s0252921100014950.

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AbstractOne of the peculiar aspects of living systems is the production and conservation of energy. This aspect is provided by specialized organelles, such as the mitochondria and chloroplasts, in developed living organisms. In primordial systems lacking specialized enzymatic complexes the energy supply was probably bound to the generation and maintenance of an asymmetric distribution of charged molecules in compartmentalized systems. On the basis of experimental evidence, we suggest that lipophilic quinones were involved in the generation of this asymmetrical distribution of charges through vectorial redox reactions across lipid membranes.

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Obst, Franziska, Anthony Beck, Chayan Bishayee, Philipp J. Mehner, Andreas Richter, Brigitte Voit y Dietmar Appelhans. "Hydrogel Microvalves as Control Elements for Parallelized Enzymatic Cascade Reactions in Microfluidics". Micromachines 11, n.º 2 (5 de febrero de 2020): 167. http://dx.doi.org/10.3390/mi11020167.

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Compartmentalized microfluidic devices with immobilized catalysts are a valuable tool for overcoming the incompatibility challenge in (bio) catalytic cascade reactions and high-throughput screening of multiple reaction parameters. To achieve flow control in microfluidics, stimuli-responsive hydrogel microvalves were previously introduced. However, an application of this valve concept for the control of multistep reactions was not yet shown. To fill this gap, we show the integration of thermoresponsive poly(N-isopropylacrylamide) (PNiPAAm) microvalves (diameter: 500 and 600 µm) into PDMS-on-glass microfluidic devices for the control of parallelized enzyme-catalyzed cascade reactions. As a proof-of-principle, the biocatalysts glucose oxidase (GOx), horseradish peroxidase (HRP) and myoglobin (Myo) were immobilized in photopatterned hydrogel dot arrays (diameter of the dots: 350 µm, amount of enzymes: 0.13–2.3 µg) within three compartments of the device. Switching of the microvalves was achieved within 4 to 6 s and thereby the fluid pathway of the enzyme substrate solution (5 mmol/L) in the device was determined. Consequently, either the enzyme cascade reaction GOx-HRP or GOx-Myo was performed and continuously quantified by ultraviolet-visible (UV-Vis) spectroscopy. The functionality of the microvalves was shown in four hourly switching cycles and visualized by the path-dependent substrate conversion.

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Obst, Franziska, David Simon, Philipp J. Mehner, Jens W. Neubauer, Anthony Beck, Oleksandr Stroyuk, Andreas Richter, Brigitte Voit y Dietmar Appelhans. "One-step photostructuring of multiple hydrogel arrays for compartmentalized enzyme reactions in microfluidic devices". Reaction Chemistry & Engineering 4, n.º 12 (2019): 2141–55. http://dx.doi.org/10.1039/c9re00349e.

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A moulding technique is presented for the simultaneous photostructuring on the μm scale of hydrogels with nanomaterials on one substrate, usable for the fabrication of microfluidic double-chamber reactors.

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Tesis sobre el tema "Compartmentalized reactions"

Hou, Jingke. "Compartmentalized enantioselective multicatalysis using polydimethylsiloxane membrane". Electronic Thesis or Diss., Ecole centrale de Marseille, 2022. http://www.theses.fr/2022ECDM0013.

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Les travaux de cette thèse ont porté sur la production d’énantiomères optiquement enrichis avec une consommation complète du substrat racémiques grâce à un nouveau système compartimenté de double réaction comportant une membrane polydimethylsiloxane (PDMS) à perméabilité sélective.D'abord, la perméabilitéde la membrane PDMS a été étudiée montrant une sélectivité de transfert des espèces en fonction de leur polarité. Par la suite, les réactions opposées d'estérification et de transestérification isolées par une membrane PDMS ont été réalisées pour produire des alcools énantioenrichis séparés à partir d'alcool racémique. Cependant, nous n’avons pas réussi à mettre en œuvre ce système en raison de l'incompatibilité du PDMS avec les conditions de transestérification. Deuxièmement, le dédoublement cinétique parallèle compartimentée combinant deux systèmes catalytiques d’énantiosélectivité opposées isolés par une membrane PDMS a été réalisée pour produire les deux produits énantio-enrichis image l’un de l’autre isolé dans chacun des compartiments à partir d'un substrat racémique. Ce concept a été établi avec succès avec le dédoublement cinétique hydrolytique de Jacobsen de l'époxyde terminal. Chacun des diols énantioenrichis peut être ainsi obtenu jusqu'à 100% de conversion à partir d'époxyde racémique. Troisièmement, le processus de résolution cinétique dynamique compartimenté combinant une résolution cinétique et une réaction de racémisation isolée par membrane PDMS a été réalisé pour produire un seul produit énantioenrichi à partir d'un substrat racémique. Ce processus énantioconvergent permet d’obtenir un seul ester allylique énantioenrichi jusqu'à 100% de conversion à partir d'alcool secondaire allylique racémique contournant les inconvénients de l'incompatibilité
The goal of this thesis was focused on the production of optically enriched enantiomers with complete consumption of racemic starting materials through newly designed double reactions system compartmentalized by a polydimethylsiloxane (PDMS) membrane with selective permeability. Firstly, the permeability of the PDMS membrane was studied showing a transfer selectivity of species depending on their polarity. Subsequently, the esterification and transesterification opposite reactions isolated by a PDMS membrane were performed to produce separated enantioenriched alcohols starting from racemic alcohols. However, we failed to set up such system due to the incompatibility of PDMS with the conditions of transesterification. Secondly, the compartmentalized parallel kinetic resolution combining two catalytic systems with opposite enantioselectivity isolated by a PDMS membrane was performed to produce both enantioenriched enantiomers, mirror image each other, isolated in each compartment starting from a racemic substrate. This concept was successfully established using the Jacobsen’s hydrolytic kinetic resolution of terminal epoxide. Each enantioenriched diol can be obtained up to 100% conversion from racemic epoxides. Thirdly, the compartmentalized dynamic kinetic resolution process combining a kinetic resolution and a racemization reaction isolated by PDMS membrane was performed to produce one single enantioenriched product starting from a racemic substrate. This enantioconvergent process allows to obtain an enantioenriched allylic ester up to 100% conversion from racemic allylic secondary alcohol circumventing the drawbacks of the incompatibility of the two catalytic system

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Libros sobre el tema "Compartmentalized reactions"

Knoche, Wilhelm y Reinhard Schomäcker, eds. Reactions in Compartmentalized Liquids. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74787-8.

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1937-, Knoche W., Schomäcker R. 1959- y Royal Society of Chemistry (Great Britain). Fast Reactions in Solution Discussion Group., eds. Reactions in compartmentalized liquids: Proceedings of a symposium held at the Zentrum für Interdisziplinäre Forschung, Bielefeld/FRG, September 11-14, 1988. Berlin: Springer-Verlag, 1989.

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Knoche, W. Reactions in Compartmentalized Liquids: Proceedings of a Symposium held at the Zentrum für interdisziplinäre Forschung, Bielefeld/ FRG, September 11.-14, 1988. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989.

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Knoche, W. Reactions in Compartmentalized Liquids: Proceedings of a Symposium Held at the Zentrum Fur Interdisziplinare Forschung, Bielefeld/Frg, September 11-1. Springer, 1989.

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Capítulos de libros sobre el tema "Compartmentalized reactions"

Crooks, J. E. "Fast Reactions in Pharmacy". En Reactions in Compartmentalized Liquids, 163–72. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74787-8_19.

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Kahlweit, M., R. Strey y R. Schomäcker. "Microemulsions as Liquid Media for Chemical Reactions". En Reactions in Compartmentalized Liquids, 1–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74787-8_1.

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Smith, P., C. Gould, G. Kelly, D. M. Bloor y E. Wyn-Jones. "Kinetic and Equilibrium Studies Associated with the Partitioning of Alcohols in Micelles". En Reactions in Compartmentalized Liquids, 83–89. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74787-8_10.

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Cherry, Richard J. "Spectroscopic Studies of Rotational Diffusion and Protein-Protein Interactions in Biological Membranes". En Reactions in Compartmentalized Liquids, 91–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74787-8_11.

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Clarke, R. J. y H. J. Apell. "Kinetics of Potential-Sensitive Fluorescent Dye Interaction with Lipid Vesicles and Application to the Measurement of Membrane Potential Transients Generated by the Na,K-Pump". En Reactions in Compartmentalized Liquids, 97–104. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74787-8_12.

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Böttcher, A., N. Dencher, R. Groll, F. Meyer y J. F. Holzwarth. "Dynamic Changes of Lipids and Bacteriorhodopsin in DMPC Bilayer Vesicles". En Reactions in Compartmentalized Liquids, 105–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74787-8_13.

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Markovski, P. y G. Todorov. "Holographic Investigations of Aqueous Suspensions of Purple Membranes". En Reactions in Compartmentalized Liquids, 117–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74787-8_14.

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Wilkinson, F., P. A. Leicester, G. P. Kelly, D. Oelkrug y M. Gregor. "The Study of Elementary Reactions at Interfaces Using Diffuse Reflectance Laser Flash Photolysis". En Reactions in Compartmentalized Liquids, 125–34. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74787-8_15.

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Mills, A., P. Douglas y G. Williams. "A Flash Photolysis Study of Colloidal Cadmium Sulphide". En Reactions in Compartmentalized Liquids, 135–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74787-8_16.

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Reinsborough, V. C., Y. E. MacPherson, R. Palepu y Josef F. Holzwarth. "Kinetics of Dye/β-Cyclodextrin Interactions". En Reactions in Compartmentalized Liquids, 145–52. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74787-8_17.

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Actas de conferencias sobre el tema "Compartmentalized reactions"

Weyland, Mathias S., Dandolo Flumini, Johannes J. Schneider y Rudolf M. Füchslin. "A compiler framework to derive microfluidic platforms for manufacturing hierarchical, compartmentalized structures that maximize yield of chemical reactions". En The 2020 Conference on Artificial Life. Cambridge, MA: MIT Press, 2020. http://dx.doi.org/10.1162/isal_a_00303.

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Mattern-Schain, Samuel I., Mary-Anne Nguyen, Tayler M. Schimel, James Manuel, Joshua Maraj, Donald Leo, Eric Freeman, Scott Lenaghan y Stephen A. Sarles. "Totipotent Cellularly-Inspired Materials". En ASME 2019 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/smasis2019-5745.

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Abstract This work draws inspiration from totipotent cellular systems to design smart materials whose compositions and properties can be learned or evolved. Totipotency refers to the inherent genetic potential of a single cell to adapt and produce all types of differentiated cells within an organism. To study this principal and apply it synthetically, tissue-like compartmentalized assemblies are constructed via lipid membrane-separated aqueous droplets in a hydrophobic medium through the droplet interface bilayer (DIB) method. Within our droplets, we explore synthetic totipotency via cell-free reactions including actin polymerization and cell free protein synthesis (CFPS). The transcription and translation of our CFPS reactions are controlled by stimuli-responsive riboswitches (RS). Via this scheme, adaptable material properties and functions are achieved in vitro via protein production from cell-free machinery administered through RS governance. Here, we present thermally or chemically-triggered riboswitches for orthogonal production of representative fluorescent protein products, as well functional proteins. To characterize the material properties of target proteins, we study the formation of polymerized actin shells to stabilize organically-encased droplets and span DIBs. We present a modified protocol for chemically-triggered actin polymerization as well as a thermally triggered actin RS. We characterize theophylline (TP)-triggered production of alpha hemolysin (α-HL) through CFPS and synthesized an organic-soluble trigger that can be sensed from the oil phase by a RS in an aqueous bioreactor droplet. We also demonstrate increased droplet conductivity when CFPS α-HL products are incorporated in DIBs. This interdisciplinary work involves cell culture, gene expression, organic synthesis, vesicle formation, protein quantification, tensiometry, droplet aspiration, microplate fluorescence/absorption experiments, fluorescent microscopy, and electrophysiology. This project is an essential design analysis for creating smart, soft materials using synthetic biology and provides motivation for artificial tissues capable of adapting in response to external stimuli.

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Baltaeva, Madina, Katerina Stamer y Maxim Orlov. "Complex Micro-Containers (CMC) Transporting Compartmentalized Reaction Mixture for Self-Healing Cement". En Middle East Oil, Gas and Geosciences Show. SPE, 2023. http://dx.doi.org/10.2118/213702-ms.

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Abstract Zonal isolation and cement sheath integrity are vital for a consistent oil and gas production process in an economic and environmentally conscious manner. However, cement is a brittle material that can fail under repeated application of stresses. The objective of this research is developing a novel material Complex micro-containers (CMC) to induce autonomous self-healing properties to the cement using the mechanism of a self-expanding polyurethane foam formation in a crack area. Complex micro-containers (CMC) consist of polyol-loaded polyurea (PUa) micro- and nanocapsules loaded inside the isocyanate-filled core of larger polyurethane (PU) microcapsules. The method of CMC creation includes several steps. During the first step, an oil-in-oil emulsion, composed of organic solvent and polyol-polyamine solution, is created. The second step is made of a polyurea shell formation directly at the surface of the polyol droplets controlled by an addition of isocyanate. As the result of the interfacial polymerization process, micro- and nanocapsules are formed. Then, they are mixed with the isocyanate solution and further emulsified in the water-based media. The droplets of isocyanate with micro- and nanocapsules are encapsulated through polyurethane shell formation by adding polyol. A variety of factors alter the morphology and size of the micro- and nanocapsules including parameters of emulsion's creation, core/shell ratio, and dispersion speed. The optimal content of isocyanate and polyols in cores of polyurea and polyurethane microcapsules, mechanical mixing parameters, and concentration of emulsifiers in oil-in-oil and oil-in-water emulsions were determined. FTIR-spectroscopy was used to identify the chemical structure and to demonstrate encapsulation of the isocyanate core and the polyurethane shell and the polyol core and polyurea shells. TGA-analysis, optical microscopy, and scanning electron microscopy methods were used to determine the core content of micro- and nanocapsules and their size. The peeling strength test proved that the release of the microcapsules’ core content occurs by pressure application and the diisocyanate reacts with polyol and water and creates the polyurethane material. The main advantage of CMC is its expandable properties due to the formation of a polyurethane foam in the presence of water that can effectively fill the micro-cracks directly in a place of cement breakage. Integration of developed new material into the cement body will allow for improving a long-term wellbore isolation and mitigating a leakage potential in the cemented annuli.

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Djanuar, Yanfidra, Qingfeng Huang, Jimmy Thatcher y Morgan Eldred. "Integrated Field Development Plan for Reliable Production Forecast Using Data Analytics and Artificial Intelligence". En Gas & Oil Technology Showcase and Conference. SPE, 2023. http://dx.doi.org/10.2118/214021-ms.

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Abstract Having a robust field development plan (FDP) for mid-size mature oil fields generally poses considerable challenges in the context of the integrational elements of production forecast, operational environment, projects and surface facilities. An integrated FDP combined with data analytics and artificial intelligence (AI) has been introduced and deployed in a heavily compartmentalized offshore field of Turkmenistan. An integrated approach through data-centric analytics and AI has been proposed for an optimal FDP. It consists of four aspects: model integration, time-series forecast (TSF) of production, AI-assisted operation-schedule generation, and evaluation and selection of scenarios. Firstly, model integration is performed as bringing together both multi-discipline raw data from field measurement and their interpretations that change non-linearly. Secondly, model integration aids in the application of AI for production forecast. A unique AI technique was built to allow raw data and interpretation. Illustratively, the model is capable of forecasting decline curves matching the history production. Meanwhile, engineers’ production forecast inheriting from simulation, machine learning or type curves is also constructed by understanding how/why human-driven forecasts differ from the measured decline and incorporating those insights. In addition, AI-assisted scheduler efficiently allocates resources for operational activities, considering the well planning nature, intrinsic operation properties, project planning process, surface facilities and expenditures. Resources are thus utilized for optimal schedules. Finally, evaluation and selection of FDP scenarios take place by considering the multidimensional matrix of factors. Multiple scenarios are generated and scored, reacting to the change of factors. AI-powered optimization is availed to recommend the most efficient tradeoffs between production and carbon generation. The implementation of the integrated FDP approach has been successfully applied for the generation of production profiles and operation schedules, which reduces the time by 80% and increasing accuracy by 55%. Production forecast for existing wells and future wells proved to be reliable. It achieved the production targets with proper allocation of schedules, by considering multi-discipline constraints. Through AI-assisted scheduler, different types of rigs were properly assigned to the planned wells, which requires additional rigs based on the outcome. The model was agile to the change and sensitivities of wells requirement, projects uncertainties and cost changes. The optimum FDP scenario was recommended for the business decision, operation guide and execution. This approach represents a novel and innovative means of integrating and optimizing FDP considering complex factors using AI methods. It is efficient in merging raw data and interpretations for model integration. It accommodates changes and uncertainties from multiple aspects and efficiently generates optimum FDP in a few days rather than months for giant fields. It is the first robust tool that unites subsurface properties, reservoir engineering, production, drilling, projects, engineering and finance for the corporate FDP.

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