Literatura académica sobre el tema "CIM-Like"

Today, the surveillance systems and other monitoring systems are considering the capturing of image sequences in a single frame. The captured images can be combined to get the mosaiced image or combined image sequence. But the captured image may have quality issues like brightness issue, alignment issue (correlation issue), resolution issue, manual image registration issue etc. The existing technique like cross correlation can offer better image mosaicing but faces brightness issue in mosaicing. Thus, this paper introduces two different methods for mosaicing i.e., (a) Sliding Window Module (SWM) based Color Image Mosaicing (CIM) and (b) Discrete Cosine Transform (DCT) based CIM on Field Programmable Gate Array (FPGA). The SWM based CIM adopted for corner detection of two images and perform the automatic image registration while DCT based CIM aligns both the local as well as global alignment of images by using phase correlation approach. Finally, these two methods performances are analyzed by comparing with parameters like PSNR, MSE, device utilization and execution time. From the analysis it is concluded that the DCT based CIM can offers significant results than SWM based CIM.

TOT as a new project financing mode, its appearance effectively solves problems like the lack of government investment funds, management inefficiency and others. But because of its complex organizational structure involving more than one principal, the potential risk is enormous. In this paper, I use AHP method to conduct comprehensive and systematic risk identification for TOT projects and establish the control interval and memory (CIM) model to assess the risks of hydropower financing. The application of CIM in engineering practice shows the effectiveness and feasibility of CIM, the comprehensive evaluation method in the risk assessment.

Background:Polymyositis (PM) is a chronic inflammatory myopathy that impairs muscle functions. While the treatment with glucocorticoids (GC) has been the cornerstone of the treatment for PM to suppress immune-mediated muscle injury, some patients suffer from glucocorticoid-induced myopathy during the treatment, which further deteriorates the muscle weakness. It has been reported that significant disability and muscle weakness persist in a quarter of the patients even after successful treatment with the immunosuppressive therapy1. Ultimately, new therapeutic strategies to preserve and recover muscle strength as well as to suppress immune-mediated muscle injury are needed. Glucagon-like peptide-1 (GLP-1) is a peptide hormone with a variety of functions. Although GLP-1 receptor (GLP-1R) agonists have been developed as an anti-diabetic therapy to promote insulin secretion, emerging data suggest that they have pleiotropic actions including anti-inflammatory effects and suppression of muscle wasting2. We presumed that GLP-1R agonists have beneficial effect on PM to preserve and recover muscle strength.Objectives:To examine the effect of a GLP-1R agonist on C protein-induced myositis (CIM), a murine model of polymyositis3, in monotherapy or in combination with prednisolone (PSL).Methods:Muscle specimens of PM patients and CIM were examined with immunohistological staining for the expression of GLP-1R. The therapeutic effect of PF1801 (ImmunoForge), a GLP-1R agonist (5 mg/kg body weight (BW)/day), in monotherapy or in combination with PSL (20 mg/kg BW/day) on CIM was examined for grip strength, muscle weight and histological muscle inflammation.Results:GLP-1R was expressed on the plasma membrane of muscle cells of PM patients and CIM. The expression levels were high in the area where inflammatory infiltrates were observed. The treatment of CIM with PF1801 in monotherapy or in combination with PSL suppressed the CIM-induced decrease in grip strength on day 14. The combination therapy with PF1801 and PSL ameliorated the CIM-induced muscle weight loss in quadriceps, while the monotherapy with PF1801 or PSL did not. The histological analysis of muscle specimens on day 14 of CIM revealed that the muscle inflammation was suppressed by the treatments with PF1801, PSL, or the combination of PF1801 and PSL. None of the mice in the combination therapy group developed histologically evident myositis, while the myositis was observed in 90%, 40% and 40 % of the mice in vehicle treated group, PF1801 treated group, and PSL treated group, respectively. The necrotic area of the muscle in CIM was also reduced in the mice treated with PF1801, PSL, or the combination of PSL and PF1801. The CIM-induced increase in spleen weight was suppressed by PF1801, PSL, or the combination of PSL and PF1801. The additive effect of PSL and PF1801 on the suppression of CIM-induced increase in spleen weight was observed.Conclusion:PF1801 ameliorated CIM-induced muscle weakness and muscle inflammation in CIM. The combination therapy with PF1801 and PSL ameliorated CIM-induced muscle weight loss. PF1801 could be a novel therapy to recover muscle weakness and to suppress muscle inflammation in PM.References:[1]Bronner IM, et al.Ann Rheum Dis.2006;65:1456–61.[2]Hong Y, et al.J Cachexia Sarcopenia Muscle. 2019;10:903-18.[3]Sugihara T, et al.Arthritis Rheum. 2007;56:1304-14.Disclosure of Interests:Mari Kamiya: None declared, Seon Uk Kim: None declared, Jeong Yeon Kim: None declared, Yeong Wook Song: None declared, Eun Young Lee: None declared, Fumitaka Mizoguchi Grant/research support from: ImmunoForge, Consultant of: ImmunoForge

Globally, physical inactivity is a concern, and children’s independent mobility (CIM) may be an important target behavior for addressing the physical inactivity crisis. The aim of this study was to examine correlates of CIM (8–12 years old) in the Canadian context to inform future interventions. CIM was measured via parent surveys. Individual, social, and environmental correlates of CIM were examined using a social–ecological framework. 1699 participants’ data were analyzed using descriptive statistics and gender-stratified linear mixed-effects models while controlling for site, area-level socioeconomic status, and type of urbanization. Individual correlates including child grade (β = 0.612, p < 0.001), language spoken at home (β = −0.503, p < 0.001), car ownership (β = −0.374, p < 0.05), and phone ownership (β = 0.593, p < 0.001) were associated with CIM. For boys, parental gender (β = −0.387, p < 0.01) was negatively associated with CIM. Parents’ perceptions of safety and environment were significantly associated with CIM. Location (i.e., site) was significantly associated with CIM (ref: Trois-Rivières; Ottawa (β = −1.188, p < 0.001); Vancouver (β = −1.216, p < 0.001)). Suburban environments were negatively associated with boys’ independent mobility (β = −0.536, p < 0.05), while walkability (400 m β = 0.064, p < 0.05; 1600 m β = −0.059, p < 0.05) was significantly associated with girls’ independent mobility only. Future research and interventions should consider targeting “modifiable factors” like children’s and parents’ perceptions of neighborhood safety and environment.

Chemotherapy for cancer patients induces damaging tissue reactions along the epithelium of the gastrointestinal tract (GIT). This chemotherapy-induced mucositis (CIM) is a serious side effect of cytotoxic drugs, and several animal models of CIM have been developed, mainly in rodents and piglets, to help understand the progression of CIM and how to prevent it. Animal models allow highly controlled experimental conditions, detailed organ (e.g., GIT) insights, standardized, clinically relevant treatment regimens, and discovery of new biomarkers. Still, surprisingly few results from animal models have been translated into clinical CIM management and treatments. The results obtained from specific animal models can be difficult to translate to the diverse range of CIM manifestations in patients, which vary according to the antineoplastic drugs, dose, underlying (cancer) disease, and patient characteristics (e.g., age, genetics, and body constitution). Another factor that hinders the direct use of results from animals is inadequate collaboration between basic science and clinical science in relation to CIM. Here, we briefly describe CIM pathophysiology, particularly the basic knowledge that has been obtained from CIM animal models. These model studies have indicated potential new preventive and ameliorating interventions, including supplementation with natural bioactive diets (e.g., milk fractions, colostrum, and plant extracts), nutrients (e.g., polyunsaturated fatty acids, short-chain fatty acids, and glutamine), and growth factor peptides (e.g., transforming growth factor and glucagon-like peptide-2), as well as manipulations of the gut microbiota (e.g., prebiotics, probiotics, and antibiotics). Rodent CIM models allow well-controlled, in-depth studies of animals with or without tumors while pig models more easily make clinically relevant treatment regimens possible. In synergy, animal models of CIM provide the basic physiological understanding and the new ideas for treatment that are required to make competent decisions in clinical practice.

e20102 Background: Chemotherapy-induced myelosuppression (CIM) is the major dose-limiting and severe complication for chemotherapy, particularly etoposide plus platinum-based therapy (EP), in patients with extensive-stage small-cell lung cancer (ES-SCLC). CIM adversely affects patient quality of life and imposes substantial economic burden. In China, there’s a scarcity of related studies, especially in large cohort. This study aims to summarize the burden and treatments of CIM in ES-SCLC patients using a nationally representative real-world database. Methods: Data were derived from 53 hospitals across 28 provinces, as part of the National Cancer Center (NCC) database. ES-SCLC patients receiving EP between 2018.1.1 and 2022.12.31 were included. CIM events, namely chemotherapy induced neutropenia (CIN), thrombocytopenia (CIT), and anemia (CRA) were identified based on laboratory tests and graded according to Common Terminology Criteria for Adverse Events (CTCAE) version 5. Incidence, treatments and impact on hospitalization cost of CIM were described. Results: 7,505 patients were included, with an average age of 61.2 years (SD = 9.02) and an average of 5.0 chemotherapy cycles (SD = 2.01). The overall incidence of CIM was 91.95%, with grade 3-4 CIM occurring in 25.09% patients. Incidence of CIN, CIT, and CRA, were 44.74%, 39.20%, and 86.48%, respectively, with febrile neutropenia at 0.72%. Among patients with CIN, 90.89% patients used granulocyte colony stimulating factor (G-CSF), and 90.56% used it prophylactically. Among patients with CIT, 17.47% used recombinant human thrombopoietin (rhTPO) and 25.49% used recombinant human interleukin-11 (rhIL-11). Among patients with CRA, 10.26% used erythropoiesis-stimulating agent (ESA). Occurrence of grade 1-2 CIM and grade 3-4 CIM may increase 9.37% and 32.36% hospitalization cost per chemotherapy cycle, respectively (¥23,316.3 vs ¥21,318.2, ¥28,217.0 vs ¥21,318.2), compared to patients without any CIM. Conclusions: Incidence of CIM is notably high among ES-SCLC patients receiving EP, and treatments like G-CSF, rhTPO, rhIL-11 and ESA are widely used. Occurrence of CIM critically escalates hospitalization cost. Innovations to protect bone marrow from chemotherapy-induced damage are promising to alleviate the burden and benefit quality of life for ES-SCLC patients.[Table: see text]

Abstract. The presented research aims to define a parametric modelling methodology that allows, in short time and at a sustainable cost, the digital acquisition, modelling and semantic structuring of urban city blocks to facilitate 3D city modelling applied to historic centres. The methodology is based on field surveying and derives 3D data for the realisation of a parametric City Information Model (CIM). This is pursued through the adoption of parametric modelling as main method combined with AI procedures like supervised machine learning. In particular, the Visual Programming Language (VPL) Grasshopper is adopted as main working environment. The methodology proposed, called Scan-to-CIM, is developed to automate the cognitive operations of interpretation and input of surveying data performed in the field in order to create LoD4 city block models in a semi-automatic way. The proposed Scan-to-CIM methodology is applied to a city block located in the historic centre of Catania, Italy.

The phase transition and critical behaviors of charged AdS black holes in [Formula: see text] gravity with a conformally invariant Maxwell (CIM) source and constant curvature are further investigated. As a highlight, this research is carried out by employing new state parameters [Formula: see text] and contributes to deeper understanding of the thermodynamics and phase structure of black holes. Our analyses manifest that the charged [Formula: see text]-CIM AdS black hole undergoes a first-order small–large black hole phase transition, and the critical behaviors qualitatively behave like a Van der Waals liquid–vapor system. However, differing from the case in Einstein’s gravity, phase structures of the black holes in [Formula: see text] theory exhibit an interesting dependence on gravity modification parameters. Moreover, we adopt the thermodynamic geometry to probe the black hole microscopic properties. The results show that, on the one hand, both the Ruppeiner curvature and heat capacity diverge exactly at the critical point, on the other hand, the [Formula: see text]-CIM AdS black hole possesses the property as ideal Fermi gases. Of special interest, we discover a microscopic similarity between the black holes and a Van der Waals liquid–vapor system.

Abstract BACKGROUND Carbapenemase-producing gram-negative bacteria (CP-GNB) are an urgent and expanding public health threat. Rapid and accurate identification of these organisms facilitates infection prevention efforts in healthcare facilities. The objective of our study was to evaluate methods to detect and identify CP-GNB. METHODS We examined 189 carbapenem-resistant GNB(CR-GNB), including Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii complex, using 3 different methods: 2 methods to screen isolates of GNB for carbapenemase production [the carbapenem inactivation method (CIM) and 2 chromogenic agars] and a molecular method (Cepheid GeneXpert Carba-R) to identify the mechanism of carbapenem resistance and the associated resistance genes (blaKPC, blaNDM, blaIMP, blaOXA-48-like, and blaVIM). RESULTS The CIM was a simple and inexpensive phenotypic screen to differentiate between CR-GNB and CP-GNB, with improved analytical performance characteristics and inter-reader correlation compared to the modified Hodge test. Both chromogenic agars evaluated (HardyCHROM CRE and chromID CARBA) were able to support growth of most of the organisms tested, including isolates possessing the blaOXA-48-like gene. However, these media had a low analytical specificity for carbapenemase production, with breakthrough of CR-GNB that did not produce a carbapenemase. The Xpert Carba-R assay was rapid and easy to perform, and demonstrated 100% positive and negative agreement for characterization of genetic determinants of carbapenem resistance. CONCLUSIONS Screening by CIM followed by the Xpert Carba-R PCR is an accurate method for detecting and characterizing CP-GNB, including Enterobacteriaceae, P. aeruginosa, and A. baumannii complex.

Un nouveau feedstock à base de polymères biosourcés et de zircone a été élaboré en vue de son utilisation pour la fabrication de pièces techniques en céramique frittée par un procédé CIM-like (Ceramic Injection Molding-like) plus respectueux de l’environnement (formulation partiellement biosourcée, absence de solvant et impression à basse température). En parallèle, un autre feedstock à base de polypropylène (PP) a été élaboré et utilisé comme référence. Chacune des étapes du procédé a été optimisée compte tenu des équipements à disposition. Les mécanismes mis en jeu ont été identifiés et les obstacles afférents ont été progressivement surmontés. Finalement des performances mécaniques satisfaisantes ont été obtenues sur les pièces frittées et permettent d’envisager raisonnablement une industrialisation et une commercialisation de feedstock développé
A new feedstock based on biobased polymers and zirconia was developed for use in the production of technical ceramic parts using a more environmentally friendly CIM-like (Ceramic Injection Molding-like) process (partially biobased formulation, solvent-free and low-temperature printing). In parallel, another feedstock based on polypropylene (PP) was developed and used as a reference. Each step of the process was optimized based on the available equipment. The mechanisms involved were identified and the associated obstacles were gradually overcome. Finally, satisfactory mechanical performance was achieved on the sintered parts, making it reasonable to consider patenting and commercializing the feedstock developed

La present tesi doctoral s’ha centrat en el repte d’aconseguir, mitjançant Fabricació Additiva (FA), models per a assaig quirúrgic, sota la premissa que els equips per fer-los haurien de ser accessibles a l’àmbit hospitalari. L’objectiu és facilitar l’extensió de l’ús dels prototips com a eina de preparació d’operacions quirúrgiques, transformant la pràctica mèdica actual de la mateixa manera que en el seu moment ho van fer tecnologies com les que van facilitar l’ús de radiografies. El motiu d’utilitzar FA, en lloc de tecnologies més tradicionals, és la seva capacitat de materialitzar de forma directa les dades digitals obtingudes de l’anatomia del pacient mitjançant sistemes d’escanejat tridimensional, fent possible l’obtenció de models personalitzats. Els resultats es centren en la generació de nou coneixement sobre com aconseguir equipaments d’impressió 3D multimaterials accessibles que permetin l’obtenció de models mimètics respecte als teixits vius. Per facilitar aquesta buscada extensió de la tecnologia, s’ha focalitzat en les tecnologies de codi obert com la Fabricació per Filament Fos (FFF) i similars basades en líquids catalitzables. La recerca s’alinea dins l’activitat de desenvolupament de la FA al CIM UPC, i en aquest àmbit concret amb la col·laboració amb l’Hospital Sant Joan de Déu de Barcelona (HSJD). El primer bloc de la tesi inclou la descripció de l’estat de l’art, detallant les tecnologies existents i la seva aplicació a l’entorn mèdic. S’han establert per primer cop unes bases de caracterització dels teixits vius -sobretot tous- per donar suport a la selecció de materials que els puguin mimetitzar en un procés de FA, a efectes de millorar l’experiència d’assaig dels cirurgians. El caràcter rígid dels materials majoritàriament usats en impressió 3D els fa poc útils per simular tumors i altres referències anatòmiques. De forma successiva, es tracten paràmetres com la densitat, la viscoelasticitat, la caracterització dels materials tous a la indústria, l’estudi del mòdul elàstic de teixits tous i vasos, la duresa d’aquests, i requeriments com l’esterilització dels models. El segon bloc comença explorant la impressió 3D mitjançant FFF. Es classifiquen les variants del procés des del punt de vista de la multimaterialitat, essencial per fer models d’assaig quirúrgic, diferenciant entre solucions multibroquet i de barreja al capçal. S’ha inclòs l’estudi de materials (filaments i líquids) que serien més útils per mimetitzar teixits tous. Es constata com en els líquids, en comparació amb els filaments, la complexitat del treball en processos de FA és més elevada, i es determinen formes d’imprimir materials molt tous. Per acabar, s’exposen sis casos reals de col·laboració amb l’HJSD, una selecció d’aquells en els que el doctorand ha intervingut en els darrers anys. L’origen es troba en la dificultat de l’abordatge d’operacions de resecció de tumors infantils com el neuroblastoma, i a la iniciativa del Dr. Lucas Krauel. Finalment, el Bloc 3 té per objecte explorar nombrosos conceptes (fins a 8), activitat completada al llarg dels darrers cinc anys amb el suport dels mitjans del CIM UPC i de l’activitat associada a treballs finals d’estudis d’estudiants de la UPC, arribant-se a materialitzar equipaments experimentals per validar-los. La recerca ampla i sistemàtica al respecte fa que s’estigui més a prop de disposar d’una solució d’impressió 3D multimaterial de sobretaula. Es determina que la millor via de progrés és la de disposar d’una pluralitat de capçals independents a fi de capacitar la impressora 3D per integrar diversos conceptes estudiats, materialitzant-se una possible solució. Cloent la tesi, es planteja com seria un equipament d’impressió 3D per a models d’assaig quirúrgic, a fi de servir de base per a futurs desenvolupaments.
La presente tesis doctoral se ha centrado en el reto de conseguir, mediante Fabricación Aditiva (FA), modelos para ensayo quirúrgico, bajo la premisa que los equipos para obtenerlos tendrían que ser accesibles al ámbito hospitalario. El objetivo es facilitar la extensión del uso de modelos como herramienta de preparación de operaciones quirúrgicas, transformando la práctica médica actual de la misma manera que, en su momento, lo hicieron tecnologías como las que facilitaron el uso de radiografías. El motivo de utilizar FA, en lugar de tecnologías más tradicionales, es su capacidad de materializar de forma directa los datos digitales obtenidos de la anatomía del paciente mediante sistemas de escaneado tridimensional, haciendo posible la obtención de modelos personalizados. Los resultados se centran en la generación de nuevo conocimiento para conseguir equipamientos de impresión 3D multimateriales accesibles que permitan la obtención de modelos miméticos respecto a los tejidos vivos. Para facilitar la buscada extensión de la tecnología, se ha focalizado en las tecnologías de código abierto como la Fabricación por Hilo Fundido (FFF) y similares basadas en líquidos catalizables. Esta investigación se alinea dentro de la actividad de desarrollo de la FA en el CIM UPC, y en este ámbito concreto con la colaboración con el Hospital Sant Joan de Déu de Barcelona (HSJD). El primer bloque de la tesis incluye la descripción del estado del arte, detallando las tecnologías existentes y su aplicación al entorno médico. Se han establecido por primera vez unas bases de caracterización de los tejidos vivos – principalmente blandos – para dar apoyo a la selección de materiales que los puedan mimetizar en un proceso de FA, a efectos de mejorar la experiencia de ensayo de los cirujanos. El carácter rígido de los materiales mayoritariamente usados en impresión 3D los hace poco útiles para simular tumores y otras referencias anatómicas. De forma sucesiva, se tratan parámetros como la densidad, la viscoelasticidad, la caracterización de materiales blandos en la industria, el estudio del módulo elástico de tejidos blandos y vasos, la dureza de los mismos, y requerimientos como la esterilización de los modelos. El segundo bloque empieza explorando la impresión 3D mediante FFF. Se clasifican las variantes del proceso desde el punto de vista de la multimaterialidad, esencial para hacer modelos de ensayo quirúrgico, diferenciando entre soluciones multiboquilla y de mezcla en el cabezal. Se ha incluido el estudio de materiales (filamentos y líquidos) que serían más útiles para mimetizar tejidos blandos. Se constata como en los líquidos, en comparación con los filamentos, la complejidad del trabajo en procesos de FA es más elevada, y se determinan formas de imprimir materiales muy blandos. Para acabar, se exponen seis casos reales de colaboración con el HJSD, una selección de aquellos en los que el doctorando ha intervenido en los últimos años. El origen se encuentra en la dificultad del abordaje de operaciones de resección de tumores infantiles como el neuroblastoma, y en la iniciativa del Dr. Lucas Krauel. Finalmente, el Bloque 3 desarrolla numerosos conceptos (hasta 8), actividad completada a lo largo de los últimos cinco años con el apoyo de los medios del CIM UPC y de la actividad asociada a trabajos finales de estudios de estudiantes de la UPC, llegándose a materializar equipamientos experimentales para validarlos. La investigación amplia y sistemática al respecto hace que se esté más cerca de disponer de una solución de impresión 3D multimaterial de sobremesa. Se determina que la mejor vía de progreso es la de disponer de una pluralidad de cabezales independientes, a fin de capacitar la impresora 3D para integrar diversos conceptos estudiados, materializándose una posible solución. Para cerrar la tesis, se plantea cómo sería un equipamiento de impresión 3D para modelos de ensayo quirúrgico, a fin de servir de base para futuros desarrollos.

Children’s independent mobility (CIM) is associated with improved physical activity and social competence among children. Despite such benefits, there is a worldwide decline in overall CIM levels, owing to the multi-factors of the insufficient supportive built environment, traffic and negative parental perception. This paper attempts to make a unique case of relooking children’s everyday mobility experiences by adopting a universal design (UD) approach. The key objectives are to (i) discuss the global evolution of CIM in comparison to UD from an Indian narrative, (ii) understand CIM though parental concerns and children’s perspective, and (iii) develop a shared connection between UD goals and CIM. These objectives were achieved by a desk-based literature review followed by a qualitative pilot study within an urban neighbourhood of Delhi. Focus group discussion with twenty children in the age group of 7–12 years and personal interview sessions with fifteen parents were conducted, which were analysed using content analysis method. The literature suggests that to date, CIM has been majorly looked upon from the two-point perspective of urban planning and health. Whereas UD provides an opportunity for bringing in the dimension of ‘culture’ into the discussion. Especially in a culturally diverse country like India, where children and parental discussions reveal concerns of safety, familiarity and proximity to child-specific destinations as a precursor for CIM levels. Overall, this study emphasises that both CIM and UD form a complementary process overarching the aim of empowering children to move freely, promoting their health, social participation and inclusion.

Abstract The goal of this study is to address fundamental limitations to achieving diesel-like efficiencies in heavy duty on-highway natural gas (NG) engines. Engine knock and misfire are barriers to pathways leading to higher efficiency engines. This study explores enabling technologies for development of high efficiency stoichiometric, spark ignited, natural gas engines. These include design strategies for fast and stable combustion and higher dilution tolerance. Additionally, advanced control methodologies are implemented to maintain stable operation between knock and misfire limits. To implement controlled end-gas autoignition (C-EGAI) strategies a Combustion Intensity Metric (CIM) is used for ignition control with the use of a Woodward large engine control module (LECM). Tests were conducted using a single cylinder, variable compression ratio, cooperative fuel research (CFR) engine with baseline conditions of 900 RPM, engine load of 800 kPa indicated mean effective pressure (IMEP), and stoichiometric air/fuel ratio. Exhaust gas recirculation (EGR) tests were performed using a custom EGR system that simulates a high pressure EGR loop and can provide a range of EGR rates from 0 to 40%. The experimental measurements included the variance of EGR rate, compression ratio, engine speed, IMEP, and CIM. These five variables were optimized through a Modified BoxBenken design Surface Response Method (RSM), with brake efficiency as the merit function. A positive linear correlation between CIM and f-EGAI was identified. Consequently, CIM was used as the feedback control parameter for C-EGAI. As such, implementation of C-EGAI effectively allowed for the utilization of high EGR rates and CRs, controlling combustion between a narrower gap between knock and lean limits. The change from fixed to parametric ignition timing with CIM targeted select values of f-EGAI with an average coefficient of variance (COV) of peak pressure of 5.4. The RSM efficiency optimization concluded with operational conditions of 1080 RPM, 1150 kPa IMEP, 10.55:1 compression ratio, and 17.8% EGR rate with a brake efficiency of 21.3%. At this optimized point of peak performance, a f-EGAI for C-EGAI was observed at 34.1% heat release due to auto ignition, a knock onset crank angle value of 10.3° aTDC and ignition timing of −24.7° aTDC. This work has demonstrated that combustion at a fixed f-EGAI can be maintained through advanced ignition control of CIM without experiencing heavy knocking events.

Ceramic recuperators could enable microturbines to achieve higher fuel efficiency and specific power. Challenges include finding a suitable ceramic fabrication process, minimizing stray heat transfer and gas leakage, mitigating thermal stress, and joining the ceramic parts to neighboring metal components. This paper describes engine and recuperator design concepts intended to address these obstacles. The engine is sized to produce twelve kilowatts of shaft power, and it has a reverse-flow compressor and turbine. Motivations for this layout are to balance axial thrust forces on the rotor assembly; to minimize gas leakage along the rotating shaft; to reduce heat transfer to the compressor diffuser; to enable the use of a simple, single-can combustor; and to provide room for lightweight ceramic insulation surrounding all hot section components. The recuperator is an annular, radial counterflow heat exchanger with the can combustor at the center. It is assembled from segmented wafers made by ceramic injection molding (CIM). These are housed in a pressure vessel to load the walls mainly in compression, and are joined together by flexible adhesives in the cool areas to accommodate thermal expansion. A representative wafer stack was built by laser-cutting, laminating, and sintering tapecast ceramic material. The prototype was tested at temperatures up to 675°C, and the results were used to validate analytical and computational fluid dynamics (CFD) models, which were then used to estimate the effectiveness of the actual design. Turbomachinery efficiencies were also calculated using CFD, and allowances were made for additional losses like bearing friction and gas leakage. Based on these component performance estimates, a cycle model indicates the engine could achieve a net fuel-to-electrical efficiency of 21%, at a core weight including the recuperator of 11 kg, or about 1 kg/kW electric output.

We are living a continuous and fast technology evolution, maybe this evolution goes faster than our capacity to assimilate what we can do with it, but the potential is clear and the future will be for those who identifies the right technology with the right application. In the information era, we are literally swimming in an ocean of structured and not structured data and thanks to the evolution in the Telecommunications technologies, all that information can be used from everywhere. However, information means nothing without the capability to analyze, extract conclusions and learn from it, which is way the technologies like treatment of Big Data and the Artificial Intelligence are crucial. Imagine how these technologies shall allow engaging the design of a part or any concept by applying rules, which will facilitate the design significantly, how the integration of the validation of the structural models by the Classification Societies will be linked directly by cloud applications. Imagine all the benefits of this two simple examples that can be implemented thanks to the potential of these technologies. The way we work with shipbuilding CAD tools is also changing thanks to the ubiquitous access to the information and the different hardware available to explode that information: AR, VR, MR, Smartphones, tablets, etc. Nevertheless, not only the way we work, but also the way we interact with shipbuilding CAD tools is changing, with technologies like natural language processes that allows having a direct conversation with the applications. The concepts that are absolutely clear from now to the future in shipbuilding is the use of Data Centric model and the concept of Digital Twin, a real and effective synchronization between what we design, what we construct, by covering the complete life cycle of the product thanks to technologies like IoT and RFID. This paper tries to explain the importance to understand how the new generations of naval architects and marine engineers are immersed in a technological world in constant and rapid evolution. The way they interacts with this ecosystem will determine the way we should define the new rules of the shipbuilding CAD systems.

A touch-based probe of a coordinate measurement machine (CMM) is generally used to validate the dimensions of the artifacts and associated features which come out of the manufacturing line against its dimensions to ensure to be within prescribed GD&T [Wilson 14] limits. Although there could be other applications using a CMM like reverse engineering, however the stated inspection process is quite crucial for maintaining quality factor and to regulate merits of the manufacturing process especially with the continuous wear-tear of the involved tooling. However this inspection process, which is considered as auxiliary process, needs to have minimum cycle time in order to effectively have more quality units to be produced. In this paper we describe Computer Aided Process Planning (CAPP) in order to complete Computer Aided Inspection (CAI) process using CMM on the work-piece which is created through Computer Aided Design (CAD) and Manufacturing (CAM). This leads to Computer Integrated Manufacturing (CIM) process. As a result, the features, which need to be inspected, could be recognized from its corresponding CAD file and appropriate information could be culled out by the Dassault Software System to calculate the approach and retract points to inspect the features [Choudhury 03]. The main objective of this research paper is to determine the shortest collision free trajectory from the retract point of one feature being inspected to the approach point of another feature being inspected so that the sequencing for the set of trajectories could be calculated through existing Traveling Sales Person (TSP) algorithm in order to shorten the total distance travelled by the CMM probe, which in turn would linearly reflect in reducing the cycle inspection time. Further since different features in the work-piece might need to be inspected by different probes, an overhead time and displacement for probe change, needs to consider in order to shorten the cycle time. These include clustering of similar type of features, which can be inspected by the same probe. Also clustering of similar type of features need to be assessed against spatial distance of separation between the clusters that the probe has to travel. Since the CMM travels at a constant low speed and the different probes are of similar shape, size and comparatively very small weight, the motion dynamics of the CMM does not influence the total distance travelled for the inspection process. Our main contribution is in the development of a spatial algorithm which not only reduces the inter-feature distance but also does that by avoiding the potential for any collision with the feature or the artifact without the use of any computer vision or collision avoidance sensor information. The resulting spatial algorithm has implicit embedded information of feature clustering, which when fed into an optimization algorithm generates a path planning which would eventually shorten the cycle time. The illustration is done with two separate simulations.

The research aims not only at the hybridisation of metal and ceramic structures via an innovative textile interface, but also at the hybridisation of conventional and additive powder technologies. In this way, multifunctional components with a geometric complexity are producible. One focus is on powder injection moulding in combination with in-mould labelling and Laser Powder Bed Fusion (LPBF). Composite components are bonded to each other by means of a metallic textile nonwoven. Due to the inherent properties of the nonwoven, like non-directional structure of thin fibres and isotropic compressibility, it can partially embedded in the ceramic substrate and sintered without damaging the composite due to the different coefficients of thermal expansion (CTE) and shrinkage behaviour of ceramics and metals. For applications in implantology, in this case zirconia is bonded with titanium via LPBF by using a steel nonwoven to create the bond between the two materials and at the same time act damage tolerant.