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Tesis sobre el tema "Cilia and ciliary motion"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 31 de julio de 2024

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1

Overgaard, Christian Edmund Yeaman Charles. "Deciliation dramatically alters epithelial function." [Iowa City, Iowa] : University of Iowa, 2009. http://ir.uiowa.edu/etd/416.

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2

Xu, Qiang, and 徐强. "Modeling the deformation of primary cilium." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47250008.

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In this thesis we developed a new mechanics model of the primary cilium and analyzed its bending behavior. The primary cilium that extends from the cell surface can detect the mechanical signals of the surrounding environment. Moreover, through its deflection and bending angle, the primary cilium can communicate with the cell regarding the extracellular. Scientists have shown that dysfunction of primary cilia can lead to many diseases as cilia are believed to play an important role in transmitting signals in cells. A good model of primary cilium can aid in the understanding of the mechani

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3

Norton, Michael M. "Modeling problems in mucus viscoelasticity and mucociliary clearance /." Online version of thesis, 2009. http://hdl.handle.net/1850/10822.

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4

Ghosh, Rajat. "Designing oscillating cilia for regulating particle motion in microfluidic devices." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/33861.

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We design actuated cilia that can maneuver microscopic particles normal to a microfluidic channel wall and transport microscopic particles parallel to the channel wall. For identifying the design specifications, we employ a hybrid LBM/LSM computational model, to simulate hydrodynamic interactions between oscillating elastic cilia and microscopic particles in a microfluidic channel. The oscillating synthetic cilia are elastic filaments tethered to the channel wall and actuated by sinusoidal force acting at their free ends. The cilia are arranged in a square pattern. The microscopic particle is

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5

Wan, Yixin. "Modulation and synchronization of eukaryotic flagella." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708434.

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6

Pruski, Michal. "ARL13B and IFT172 truncated primary cilia and misplaced cells." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231675.

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Primary cilia are cellular organelles that protrude into the extracellular space, acting as antennas. They detect a wide range of chemical cues, including SHH and PDGF, as well as fluid flow, and they modulate downstream signalling systems, such as WNT and ERK. Due to this cue-sensing ability and the close association of the primary cilium with the centrosome the organelle is able to influence both cell cycle progression and cell migration. This work investigated the effect of mutations on two genes associated with primary cilia: Arl13b and Ift172. The effects of the HNN genotype of Arl13b and

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7

Hughes, Rhome. "Immunohistochemical characterization of neuronal cilia in the rat central nervous system." Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3136/.

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An anti-G"11 antibody was used to label neuronal cilia throughout the rat central nervous system. Immunoreactive cilia were observed in every examined region of the rat CNS, but not in monkey or mouse tissue. Antibodies to G"q and G"q/11 failed to label cilia. Immunoreactive cilia were observed as early as postnatal day 0 in spinal tissue, and postnatal day 3 in hypothalamic tissue. There was a statistically significant negative correlation between a region's mean cilium length and that region's distance to the nearest ventricle; regions nearest ventricles were those with the longest cilia. T

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8

Wilson, Gabrielle. "The role of the parkin co-regulated gene (PACRG) in male fertility /." Connect to thesis, 2009. http://repository.unimelb.edu.au/10187/5806.

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Thesis (Ph.D.)--University of Melbourne, Dept. of Paediatrics, The Bruce Lefroy Centre for Genetic Health Research, The Murdoch Childrens Research Institute, 2009.<br>Typescript. Includes bibliographical references (leaves 183-207)

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9

Subedi, Ashok. "Roles of Primary Cilia in the Oligodendrocyte Lineage." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1404594/.

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Primary cilia are nonmotile, hair-shaped organelles that extend from the basal body in the centrosome. The present study is the first investigation of this organelle in the oligodendrocyte lineage in vivo. I used immunohistochemical approaches in normal and cilia-deficient mutant mice to study cilia in relation to oligodendrogenesis and myelination. Primary cilia immunoreactive for Arl13b and ACIII were commonly present in NG2+ oligodendrocyte progenitor cells (OPCs), in which cilia-associated pathways control proliferation, differentiation, and migration. The loss of primary cilia is generall

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10

Mahato, Deependra. "Mutation of Polaris, an Intraflagellar Transport Protein, Shortens Neuronal Cilia." Thesis, University of North Texas, 2005. https://digital.library.unt.edu/ark:/67531/metadc4856/.

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Primary cilia are non-motile organelles having 9+0 microtubules that project from the basal body of the cell. While the main purpose of motile cilia in mammalian cells is to move fluid or mucus over the cell surface, the purpose of primary cilia has remained elusive for the most part. Primary cilia are shortened in the kidney tubules of Tg737orpk mice, which have polycystic kidney disease due to ciliary defects. The product of the Tg737 gene is polaris, which is directly involved in a microtubule-dependent transport process called intraflagellar transport (IFT). In order to determine the imp

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11

Kwok, Pui-wai. "The effects of gelomyrtol forte on human ciliary beat frequency and intracellular cyclic adenosine monophosphate in vitro /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38296913.

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12

Kwok, Pui-wai, and 郭佩瑋. "The effects of gelomyrtol forte on human ciliary beat frequency and intracellular cyclic adenosine monophosphate in vitro." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B4501291X.

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13

Bhattarai, Samip Ram. "Characteristics of Primary Cilia and Centrosomes in Neuronal and Glial Lineages of the Adult Brain." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc801939/.

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Primary cilia are sensory organelles that are important for initiating cell division in the brain, especially through sonic hedgehog (Shh) signaling. Several lines of evidence suggest that the mitogenic effect of Shh requires primary cilia. Proliferation initiated by Shh signaling plays key roles in brain development, in neurogenesis in the adult hippocampus, and in the generation of glial cells in response to cortical injury. In spite of the likely involvement of cilia in these events, little is known about their characteristics. Centrosomes, which are associated with primary cilia, also have

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14

Feriani, Luigi. "Understanding the collective dynamics of motile cilia in human airways." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288418.

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Eukaryotic organisms rely on the coordinated beating of motile cilia for a multitude of fundamental reasons. In smaller organisms, such as Paramecium and the single cell alga Chlamydomonas reinhardtii, it is a matter of propulsion, to swim towards a higher concentration of nutrients or away from damaging environments. Larger organisms use instead the coordinated motion of cilia to push fluid along an epithelium: examples common to mammals are the circulation of cerebrospinal fluid in the brain, the transport of ovules in the fallopian tubes, and breaking the left/right symmetry in the embryo.

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15

Coronel, Marco V. "Effects of Brain Injury on Primary Cilia of Glial Cells and Pericytes." Thesis, University of North Texas, 2016. https://digital.library.unt.edu/ark:/67531/metadc955100/.

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Glial cells maintain homeostasis that is essential to neuronal function. Injury to the nervous system leads to the activation and proliferation of glial cells and pericytes, which helps to wall off the damaged region and restore homeostatic conditions. Sonic hedgehog is a mitogen which is implicated in injury-induced proliferation of glial cells and pericytes. The mitogenic effects of sonic hedgehog require primary cilia, but the few reports on glial or pericyte primary cilia do not agree about their abundance and did not address effects of injury on these cilia. Primary cilia are microtubule-

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16

Duncan, Robert Keith. "Finite-element analysis of inner ear hair bundles : a parameter study of bundle mechanics /." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-09292009-020226/.

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17

Aragão, Pedro Henrique Arruda. "Estudo do Movimento Ciliar de Macrostomum Tuba Utilizando Métodos de Microscopia Eletrônica\"." Universidade de São Paulo, 1996. http://www.teses.usp.br/teses/disponiveis/43/43133/tde-02072013-103757/.

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Nossa proposta de trabalho visava estudar as propriedades do movimento ciliar, aplicando técnicas de microscopia eletrônica de varredura.. Escolheu-se como material de estudo a espécie Macrostomum tuba (turbelário), bastante comum em ambientes naturais de água doce, e em aquários. Sua superfície é inteiramente revestida por cilios, que o animal usa como meio locomoção suave e rápida. Cílios são estruturas em forma de projeções delgadas de células, com uma notável organização interna, constante em todas as espécies animais, e são dotados de movimento oscilatório rítmico e autônomo. O batimento

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18

Blanchon, Sylvain. "Etude de la diversité phénotypique et génotypique des dyskinésies ciliaires primitives : vers une prise en charge personnalisée." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC0073.

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19

Jory, Myriam. "Approche biophysique de la fonction muco-ciliaire de l'épithélium bronchique : propriétés d'écoulement du mucus et coordination du battement ciliaire." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS078.

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Comprendre et soigner les pathologies respiratoires chroniques constituent des enjeux médicaux croissants du fait des modifications de nos modes de vie et de notre environnement. L’épithélium des voies respiratoires assure le rôle de première barrière contre les agressions extérieures grâce à la fonction muco-ciliaire. Les deux éléments fonctionnels de la fonction muco-ciliaire sont la couche de mucus sécrétée par l’épithélium et le battement des cils des cellules ciliées qui contribue à la mise en mouvement de cette couche et à son évacuation des bronches. Le mucus est un fluide complexe et h

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20

Ferreira, Rita Joana Rodrigues da Silva Rua. "Cilia motility studies in zebrafish embryos." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/7984.

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A thesis submitted in fulfilment of the requirements for the degree of Masters in Molecular Genetics and Biomedicine<br>Motile ciliary dysfunctions cause specific Ciliopathies that affect mainly the respiratory tract, fertilization and left-right body establishment. The embryonic organ where left-right decisions are first taken is called the organizer, a ciliated organ where a leftward cilia driven fluid-flow is generated. The organizer is named node in the mouse and Kupffer’s vesicle (KV) in zebrafish. The correct left-right axis formation is highly dependent on signaling pathways downstream

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21

Shah, Alok Shirish. "Structural maintenance and chemosensory function of human airway motile cilia." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/2983.

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Cilia are finger-like projections that extend from the surface of most cells. These microtubule-based structures serve important mechanical or sensory functions. Motile cilia have been implicated in fluid movement whereas the non-motile primary cilia have been shown to play a role in sensory signal transduction. There exists a dichotomy in the field that primary cilia have only sensory function and motile cilia only have mechanical function. The central question of this thesis project is "what are the structural and functional components of airway motile cilia and are these cilia sensory?" In

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22

Mao, Suifang. "Motile cilia of human airway epithelia mediate noncanonical hedgehog signaling." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6195.

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During embryogenesis, airway epithelial cells possess primary cilia, and HH signaling guides lung development. As epithelial cells mature, they produce hundreds of motile cilia and continue to produce the sonic hedgehog (SHH) ligand, which is found apically in the thin layer of liquid covering airways. However, whether ciliated airway cells express apical HH signaling components and what their function might be have remained unknown. Here we show that motile cilia are enriched for HH signaling proteins, including patched 1 and smoothened. These cilia are also enriched for proteins affecting cA

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23

Sampaio, Pedro Rafael Martins de Almeida. "Using cilia mutants to study left-right asymmetry in zebrafish." Master's thesis, Faculdade de Ciências e Tecnologia, 2014. http://hdl.handle.net/10362/13155.

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A thesis submitted in fulfillment of the requirements for the degree of the Masters in Molecular Genetics and Biomedicine<br>In vertebrates, internal organs are positioned asymmetrically across the left-right (L-R) body axis. Events determining L-R asymmetry occur during embryogenesis, and are regulated by the coordinated action of genetic mechanisms. Embryonic motile cilia are essential in this process by generating a directional fluid flow inside the zebrafish organ of asymmetry, called Kupffer’s vesicle ﴾KV). A correct L-R formation is highly dependent on signaling pathways downstream of s

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24

McIntosh, Kate. "The extra ciliary roles of Meckel-Gruber syndrome proteins." Thesis, University of Exeter, 2015. http://hdl.handle.net/10871/20774.

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Meckel-Gruber syndrome (MKS) is a recessive genetic disease that is uniformly lethal in affected children due to resultant developmental defects in the kidney and brain. 13 MKS genes have been identified, and further candidate genes have been linked to this disease, all encoding unrelated proteins. Their role is believed to be in generation and compartmentalisation of the primary cilium, a microtubule-based organelle that functions in signal transduction of developmentally-crucial pathways. However, recent evidence indicates that these proteins are also likely involved in regulation of the act

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25

Subramanian, Aswati. "p28 DYNEIN LIGHT CHAINS AND CILIARY MOTILITY IN Tetrahymena thermophila." Miami University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1389719903.

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26

Mali, Girish Ram. "Multisystem functional characterisation of motile ciliopathy genes HEATR2 and ZMYND10." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21683.

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Cilia are polarized extensions of the cells microtubule-based cytoskeleton dedicated to sensory, signaling and motility-related functions. In mammals, there are two main types of cilia, immotile and motile, where motile cilia generate/modulate fluid flow at the embryonic node, in respiratory airways, cerebral ventricles and the oviduct in addition to sperm propulsion via the flagellum. Defects in cilia motility cause a rare genetic disorder called Primary Ciliary Dyskinesia (PCD). In this thesis, I present functional and molecular characterisation of two PCD causing genes HEATR2 and ZMYND10. C

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27

Moore, Daniel John. "Identification and characterisation of conserved ciliary genes expressed in Drosophila sensory neurons." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17918.

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Drosophila provide an excellent model organism in which to study cilia as there are only two ciliated cell types; the sensory neurons and sperm cells. The chordotonal neuron is one such ciliated cell and is required for hearing, proprioception and gravitaxis. Mechanical manipulation of the cilium that extends from the neuronal dendrite is required for signal transduction. Chordotonal neuronal differentiation is regulated by a transcription factor cascade. Atonal begins the cascade, which is then continued by RFX and Fd3F for ciliary genes (Cachero et al 2011, Newton et al 2012). Genes expresse

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28

Nozaki, Shohei. "Architecture of the BBSome and its role in ciliary protein trafficking." Kyoto University, 2019. http://hdl.handle.net/2433/242664.

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29

Deckman, Cassandra M. "DEPHOSPHORYLATION OF INNER ARM 1 IS REQUIRED FOR CILIARY REVERSALS IN TETRAHYMENA THERMOPHILA." Miami University / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=miami1054064051.

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30

Liu, Siming. "TESTING THE MULTI-DYNEIN HYPOTHESIS BY MUTATING INNER ARM DYNEIN HEAVY CHAINS IN TETRAHYMENA THERMOPHILA." Miami University / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=miami1077152822.

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31

Failler, Marion. "Mise en évidence et caractérisation de nouveaux gènes impliqués dans les ciliopathies rénales." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T031/document.

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32

Mokhtarpour, Vanaki Shayan. "Numerical investigation of muco-ciliary transport." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/203744/1/Shayan_Mokhtarpour%20Vanaki_Thesis.pdf.

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The human airways are protected from inhaled external substances by an extremely thin layer called airway surface liquid. This film of liquid captures most of the inhaled toxic particles and is constantly propelled back out of the airway by a dense mat of beating hair-like structures, thus cleansing the airways of inhaled pathogens. It is vital to better understand this clearance process under diseased conditions and to predict the fate of therapeutic drug particles after deposition. An advanced numerical model is developed to investigate these objectives, given that the complex nature of lung

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33

KABI, AMRITA. "Role of Inner Arm Dyneins and Hydin in Ciliary Motility in Tetrahymena thermophila." Miami University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=miami1271977227.

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34

Inganni, Johan. "Nitric Oxide in Primary Ciliary Dyskinesia : Missing in action?" Thesis, Södertörn University College, School of Life Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-1608.

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35

Bright, Alison R. "A Role for Intraflagellar Transport Proteins in Mitosis: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/682.

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Disruption of cilia proteins results in a range of disorders called ciliopathies. However, the mechanism by which cilia dysfunction contributes to disease is not well understood. Intraflagellar transport (IFT) proteins are required for ciliogenesis. They carry ciliary cargo along the microtubule axoneme while riding microtubule motors. Interestingly, IFT proteins localize to spindle poles in non-ciliated, mitotic cells, suggesting a mitotic function for IFT proteins. Based on their role in cilia, we hypothesized that IFT proteins regulate microtubule-based transport during mitotic spindle asse

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36

Bright, Alison R. "A Role for Intraflagellar Transport Proteins in Mitosis: A Dissertation." eScholarship@UMMS, 2006. http://escholarship.umassmed.edu/gsbs_diss/682.

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Disruption of cilia proteins results in a range of disorders called ciliopathies. However, the mechanism by which cilia dysfunction contributes to disease is not well understood. Intraflagellar transport (IFT) proteins are required for ciliogenesis. They carry ciliary cargo along the microtubule axoneme while riding microtubule motors. Interestingly, IFT proteins localize to spindle poles in non-ciliated, mitotic cells, suggesting a mitotic function for IFT proteins. Based on their role in cilia, we hypothesized that IFT proteins regulate microtubule-based transport during mitotic spindle asse

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37

Mohieldin, Ashraf M. "Cellular Function and Structure of Primary Cilia." University of Toledo Health Science Campus / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=mco1438784302.

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38

Rachev, Ev [Verfasser], Achim [Akademischer Betreuer] Gossler, and Dietmar J. [Akademischer Betreuer] Manstein. "Characterization of CFAP43 and its function in motile cilia / Ev Rachev ; Akademische Betreuer: Achim Gossler, Dietmar Manstein ; Institut für Molekularbiologie." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2018. http://nbn-resolving.de/urn:nbn:de:gbv:354-20171115154.

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39

Rachev, Ev [Verfasser], Achim Akademischer Betreuer] Gossler, and Dietmar J. [Akademischer Betreuer] [Manstein. "Characterization of CFAP43 and its function in motile cilia / Ev Rachev ; Akademische Betreuer: Achim Gossler, Dietmar Manstein ; Institut für Molekularbiologie." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2018. http://d-nb.info/1153482509/34.

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40

Rachev, Ev Verfasser], Achim [Akademischer Betreuer] Gossler, and Dietmar J. [Akademischer Betreuer] [Manstein. "Characterization of CFAP43 and its function in motile cilia / Ev Rachev ; Akademische Betreuer: Achim Gossler, Dietmar Manstein ; Institut für Molekularbiologie." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2018. http://d-nb.info/1153482509/34.

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41

Chavez, Garcia Edison. "Phosphoinositides regulation and function in the ciliary compartment of Neural stem cells and Ependymal cells." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/221625.

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This thesis describes the work that I have carried out in the Laboratory of Neurophysiolgy at the Université Libre de Bruxelles, under the supervision of Prof. Serge Schiffmann, in collaboration with Prof. Stéphane Schurmans of Université of Liège.The work is divided in two distinct but related projects and the results section is thus divided into two main chapters. The results described are presented in the form of two manuscripts, the first chapter is named “Ciliary phosphoinositides regulation by INPP5E controls Shh signaling by allowing trafficking of Gpr161 in neural stem cells primar

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42

Follit, John A. "Building the Cell's Antenna: Protein Targeting to the Ciliary Membrane: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/594.

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Protruding from the apical surface of nearly every cell in our body lies a specialized sensory organelle—the primary cilium. Eukaryotic cells use these ubiquitous structures to monitor the extracellular environment, defects in which result in an ever-growing list of human maladies termed ciliopathies including obesity, retinal degeneration and polycystic kidney disease. The sensory functions of primary cilia rely on the unique complement of receptors concentrated within the ciliary membrane. Vital to the proper functioning of the cilium is the cell's ability to target specific proteins to the

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43

Fowler, Cedar. "Identification of a ciliary defect associated with pulmonary nontuberculous mycobacterial disease." Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/245062.

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Over the past several decades, the rate of pulmonary nontuberculous my- cobacterial (PNTM) disease has been increasing. PNTM patients gener- ally consist of lean and tall women presenting with symptoms in the sixth decade of life. They have a de nitive morphophenotype, but no consistent immunological abnormalities despite extensive investigation. I hypothesized that respiratory epithelial dysfunction might play a critical role in PNTM disease predisposition because diseases with defects of mucociliary transport have high rates of PNTM disease that increase with age, suggesting a direct connect

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44

Puybareau, Elodie. "Motion analysis for Medical and Bio-medical applications." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC1063/document.

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L’analyse du mouvement, ou l’analyse d’une séquence d’images, est l’extension naturelle de l’analyse d’images à l’analyse de séries temporelles d’images. De nombreuses méthodes d’analyse de mouvement ont été développées dans le contexte de la vision par ordinateur, incluant le suivi de caractéristiques, le flot optique, l’analyse de points-clef, le recalage d’image, etc. Dans ce manuscrit, nous proposons une boite a outils de techniques d’analyse de mouvement adaptées à l’analyse de séquences biomédicales. Nous avons en particulier travaillé sur les cellules ciliées qui sont couvertes de cils

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45

Shebani, Eyman. "Ultrastructural Studies of the Airway Epithelium in Airway Diseases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6632.

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46

Lorenzo, Moldero Ivan. "Localization and regulation of trpv4 channels in CILIATED epithelia." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7185.

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La neteja del moc i dels patògens dels pulmons, i el transport de gàmets i embrions en els òrgans reproductius de les femelles són funcions clau en els epitelis ciliats, tals com aquells que es troben presents en les vies respiratòries i l'oviducte. La taxa de transport mucociliar és funció de la freqüència de batut ciliar (CBF) i aquesta freqüència és augmentada per increments en la concentració de Ca2+ intracelul·lar. El canal catiònic "transient potential vanilloid 4" (TRPV4) intervé en l'entrada de Ca2+ en resposta a estímuls mecànics i osmòtics. L'expressió del TRPV4 en l'epiteli ciliat d

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47

Laligné, Chloé. "Étude de la fonction de la protéine Bug22p dans différents organismes." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00746881.

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Les cils sont des organites très conservés au cours de l'évolution des eucaryotes et présents à la surface de presque tous les types cellulaires. Ils sont constitués d'une structure microtubulaire, l'axonème, entourée d'une membrane en continuité avec la membrane plasmique. Ils sont nucléés par un corps basal, centriole ancré à la surface cellulaire. Grâce aux nombreux récepteurs qu'ils concentrent à leur membrane, tous les cils sont des senseurs de leur environnement. Ils peuvent aussi être motiles et assurer, par leur battement coordonné, le déplacement relatif de la cellule et du fluide env

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Thomas, Lucie. "Bases moléculaires et cellulaires de l'assemblage de l'axonème des cils mobiles." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS097.pdf.

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Les bras de dynéine (BDs), moteurs du mouvement ciliaire et flagellaire, sont ancrés à intervalles réguliers le long de l'axonème des cils mobiles et des flagelles. Les dyskinésies ciliaires primitives (DCP) sont des maladies respiratoires rares, de transmission essentiellement autosomique récessive, liées à un défaut des cils mobiles, souvent associées à une infertilité masculine. Environ 25% des patients DCP présentent une absence des BDs externes et internes. Ces patients portent des mutations dans un des 13 gènes impliqués qui codent, pour la plupart, des constituants des complexes cytopla

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Lacouture, Loïc. "Modélisation et simulation du mouvement de structures fines dans un fluide visqueux : application au transport mucociliaire." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS139/document.

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Une grande part des muqueuses à l’intérieur du corps humain sont recouvertes de cils qui, par leurs mouvements coordonnés, conduisent à une circulation de la couche de fluide nappant la muqueuse. Dans le cas de la paroi interne des bronches, ce processus permet l’évacuation des impuretés inspirées à l’extérieur de l’appareil respiratoire.Dans cette thèse, nous nous intéressons aux effets du ou des cils sur le fluide, en nous plaçant à l’échelle du cil, et on considère pour cela les équations de Stokes incompressible. Due à la finesse du cil, une simulation directe demanderait un raffinement im

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Mianné, Joffrey. "Thérapie génique par CRISPR/Cas9 pour corriger des épithéliums bronchiques dérivés de cellules souches pluripotentes induites (iPSCs) de patients atteints de dyskinésie ciliaire primitive (DCP) : une preuve de concept." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT045.

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La dyskinésie ciliaire primitive (DCP) est une maladie génétique rare et hétérogène affectant la structure et la fonction des cils motiles. Dans l'épithélium des voies respiratoires, l’altération du mouvement ciliaire entraîne des infections chroniques responsables du déclin progressif et définitif des fonctions pulmonaires. Il n'existe actuellement aucun traitement efficace pour la DCP. Par ailleurs, la recherche de nouvelles thérapies reste limitée par le manque de modèles fiables.Dans ce contexte, les deux objectifs de cette thèse sont : 1) de développer un nouveau modèle in vitro de la DCP

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