Tesis sobre el tema "Chaîne de distribution pharmaceutique"
Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros
Consulte los 50 mejores tesis para su investigación sobre el tema "Chaîne de distribution pharmaceutique".
Junto a cada fuente en la lista de referencias hay un botón "Agregar a la bibliografía". Pulsa este botón, y generaremos automáticamente la referencia bibliográfica para la obra elegida en el estilo de cita que necesites: APA, MLA, Harvard, Vancouver, Chicago, etc.
También puede descargar el texto completo de la publicación académica en formato pdf y leer en línea su resumen siempre que esté disponible en los metadatos.
Explore tesis sobre una amplia variedad de disciplinas y organice su bibliografía correctamente.
Chapuis, Charles. "Qualification et validation d'une chaine de production et de distribution d'eau distillée dans l'industrie pharmaceutique". Bordeaux 2, 1996. http://www.theses.fr/1996BOR2P011.
Texto completoAit, Mamoun Khadija. "Vehicle rοuting prοblem under uncertainty : case οf pharmaceutical supply chain". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMIR08.
Texto completoThe enhancement of logistics distribution performance and the optimization of transportation have emerged as critical concerns in recent years. The pharmaceutical distribution sector faces significant challenges in route planning and transport network optimization, with uncertainties often leading to delays and losses. The multifaceted challenges encompass the imperative to elevate product quality, reduce costs, minimize total travel distance, and streamline transportation time for effective planning. Within this context, the Vehicle Routing Problem (VRP) stands out as one of the extensively analysed problems in the realms of transportation, distribution, and logistics. Achieving a delicate equilibrium between cost considerations and delivering high-quality pharmaceutical products is a primary objective in pharmaceutical distribution. This research delves into both the Static Vehicle Routing Problem (SVRP) and the Dynamic Vehicle Routing Problem (DVRP). Real-world logistical planning frequently encounters uncertainties at the outset, including uncertain customer demand, delivery quantities, time constraints, and more. This thesis introduces the "temperature condition" as a fundamental constraint in pharmaceutical distribution, representing a source of uncertainty that directly impacts drug quality, thereby influencing logistics distribution and overall supply chain performance. Furthermore, the thesis incorporates uncertainty quantification for modelling uncertain travel times in both recurrent and non-recurrent congestion scenarios. The methodology employed for this purpose is the collocation method, initially validated through Monte Carlo Simulation (MCS). By addressing these multifaceted challenges and uncertainties, this research seeks to contribute to the development of robust strategies in pharmaceutical distribution, ensuring the optimization of routes, reduction of costs, and maintenance of high-quality product standards. The findings of this study offer valuable insights for logistics managers and planners aiming to navigate the complexities of pharmaceutical distribution, fostering efficiency and resilience in the face of uncertainties
Bouazza, Diden. "La distribution des médicaments en Algérie : étude comparative". Clermont-Ferrand 1, 1988. http://www.theses.fr/1988CLF10060.
Texto completoThe study of medecine delivery in Algeria gives us a reflection about pharmaceutics policy since national independance. Beyong transformations, the distribution plan, based on a liberal concept, reveals a lag in the pre-arranged options. Manufacturing monopolization of medecines shows the problem of delivery structures ; importing stiel remains the man feature of health planing in the country. Aucht socialization makes the consumer interest rank below. The system measure allows to set up professionals passivity or that of chemists, not only within the delivery flour, but also within the organism in which it defends its profession. The professional's formation and information shows the advantage of setting the problem of medecine delivery to the consumer. The chemist's statue is rather badly defined, and althought the latter is contrained to strict obligations in professional practising, his intervention remains limited in the consume's education - his advices and information are lacking. This call a rational delivery of the medicine in question. However, as for a specific activity, delivering medicines must deal with severe rules in order to protect public health in addition to these restaints, the chemist has to deal with the inflingements done within the profession
Harreguy, Annabelle. "L'externalisation de la distribution pharmaceutique en France : les prestataires logistiques". Bordeaux 2, 2000. http://www.theses.fr/2000BOR2P018.
Texto completoDesgrippes, Emmanuel. "Coordination entre la production et la distribution dans une chaîne logistique". Grenoble INPG, 2005. http://www.theses.fr/2005INPG0072.
Texto completoThis thesis deals with the coordination between different activities in a supply chain, actually between the production and the distribution of finished goods. It is inspired of an industrial case of production and distribution of pick-ups in Thailand. First the problem is modeled as a mixed integer linear program optimizing bath production and distribution. Then the coordination is approached focusing on the production part and then on the transportation part. The distribution problem on a tree (due to the specifie shape of the network) is solved with sorne assumptions, the general problem being NP-complete. The production problem, considered separately, is also solved by a polynomial algorithm. We also show a link between production and distribution on a single line network, and batch scheduling. We propose an efficient dynamic programming procedure to solve this special case. Finally, heuristics based on list algorithms are designed to deal with the coordination problem
Estime, Nicolas. "Contrôle des propriétés des cristaux d'un principe actif pharmaceutique dans la chaîne précipitation - filtration - séchage : vers un procédé continu". Thesis, Toulouse, INPT, 2010. http://www.theses.fr/2010INPT0069.
Texto completoThis study deals with the development of a methodology allowing to transform a batch precipitation process in a continuous one. The active substance considered is acetyl-L-leucine. The work is focused on the precipitation step but also considers the interactions with the downstream processes of filtration, washing and drying. In a first part, characterization methods of pure and impure solutions of active substance were developed as well as methods for determining the crystals properties (purity, size, size distribution, shape, ...). Then the solubility of the product was investigated and the influence of parameters such as temperature, pH, impurity concentration, was studied. The crystallization mode of the racemic mixtures was also determined . Finally, batch crystallization was carried out at the laboratory scale in order to determine nucleation kinetics and to understand the main operating parameters influencing the quality of the crystals. For the applied range of concentrations, the induction time was found very small and indicates that the control of the nucleation step is difficult and depends on the mixing of the reactants. The whole continuous process was finally designed and tested, from the initial reactive to the final dry ZPI powder, in industrial site to validate the feasibility of the continuous process
Testanière, Denis. "Stratégies de distribution et organisations d'achat : évolution en industrie pharmaceutique et parapharmaceutique". Paris 1, 1993. http://www.theses.fr/1993PA010046.
Texto completoThe traditional distribution network of pharmaceutics includes very different products: the prescribed medecines, the "over the counter" drugs and the other products sold in a drugstore (cosmetics and accessories). The usual networks of distribution, mainly the pharmacy, are questioned under the pressure of several factors related to the concept of health cost, related to the knowledge of customers needs or related to the development of communication. The competition with other commerces, the selective distribution (perfumeries, "grands magasins"), the stores ("hypermarches") or the direct marketing ("vente par correspondance"), is difficult and involves deep changes of the present pharmacy organization. The chemist's shops are reacting by gathering, in the form of "groupements" which aspire to turn into a real distribution net work or a franchised network. On the one hand the present set of laws regarding to the pharmacies and on the other hand the turn of mind of some independant druggists restrict this trend. Nevertheless, the distribution network is beeing transformed into health-specialized stores, organized by chains of shops which will provide a large choice of prices and a self-service department concerning a lot of products, including the "automedication" drugs (which will become real "over-the-counter" drugs). These stores will exist beside smaller shops, with a high degree of specialization, veterinary drugs-specialized or orthopedics-specialized for example. In any case, the most important factors of the future distribution network success will be the advices and the quality of service
Corbin, Elsa. "Enjeux et limites de l'introduction du supply chain management dans la chaîne logistique pharmaceutique : une perspective des grossistes répartiteurs portoricains". Antilles-Guyane, 2006. http://www.theses.fr/2006AGUY0580.
Texto completoIn United States, the pharmaceutical laboratories have decided to tackle the numerous sources of wastes existing in the pharmaceutical supply chain. Although we are still far from a generalization of these practices, as well we are far from a generalization of supply chain management practices in the pharmaceutical supply chain, lean manufacturing and the introduction of the Inventory Management Agreement (IMA) --announcing the beginning of a new era in the drug supply chain--are the new solutions introduced in order to reach a better pharmaceutical supply chain management The Inventory Management Agreement, signed between the pharmaceutical laboratories and the wholesalers -who, during years, managed the drug marketing channel-, should help today to leave behind speculative strategies in favour of practices permitting to decrease the level of stocks all along the drug supply chain. The transformations that the laboratories want to impulse reconsider the presence of the wholesalers as essential actors within the pharmaceutical supply chain. These ones are forced to introduce supply chain management practices as they do not want to be seen as an obstacle for an efficient management of the supply chain preventing them to be, in the future, maintained as a full actor within the drug supply chain
Hichri, Gaël. "La distribution pharmaceutique : Essai sur l'organisation d'un secteur économique réglementé en droit privé". Montpellier 1, 2007. http://www.theses.fr/2007MON10049.
Texto completoThe distribution of pharmaceutical products is a highly regulated economic sector. Seen from a private law standpoint, it is considered a matter of economic public order, and its regulation covers, by definition, contractual relationships between distributors in so far as such contracts are the legal supports of a regulated trade. This said, the regulations do allow distributors a certain freedom to organise their commercial interests. These regulations have a single purpose: to organise pharmaceutical distribution so as to best protect the public health within a controlled financial context. In view of this, the regulating organisation of pharmaceutical distribution is based as much on a multitude of specific transactions corresponding to general obligations towards the public health, as it is upon a tightly controlled pricing framework. This organisation of distribution transactions therefore touches indirectly upon distribution contracts. So long as distributors practice their trade within the framework of these regulations, they are otherwise free to organise with their commercial interests in mind. The organization of pharmaceutical distribution can therefore be determined in an isolated manner, on the initiative of a single operator, either so as to discipline retail dealers, or so as to open up new outlets for expansion. The organization of distribution can also be managed collectively, from within pharmacy networks designed to strengthen commercial relationships between distributors. Pharmaceutical distributors have thus borrowed techniques proven effective by large-scale distribution, specialized distribution and electronic distribution. However, these modes of organization cannot be put to use as is, and must be adapted to the particularities of the pharmaceutical sector. Although the adoption of these techniques is still controversial, their study is noneless essential, since they are inevitably precursors to the future development of pharmaceutical distribution
Berrada, El Azizi Mohamed. "Modélisation multi-agents de la coopération au sein des chaînes logistiques à deux échelons : application à la distribution de produits pharmaceutiques au Maroc". Thesis, Paris 13, 2014. http://www.theses.fr/2014PA131020/document.
Texto completoAThis thesis is composed by two papers focusing on two-level supply chains with a monopoly supplier and N clients whose demands for the same products are correlated. The first paper studies the simultaneous impact of vertical and horizontal cooperation on the overall performance and the stability of the chain. It proposes an individual-centered multi-agents approach for studying the impact on performance of different kinds of customer behaviors associated with overstock risk and their interaction rules under possible distortion of the exchanged information. The second paper deals with pharmaceutical distribution and studies the influence of the cooperation between wholesale distributors and a unique supplier to reduce overstocks and wastes. More generally, this thesis has shown the relevance of a connectionist approach of complex supply chains with heterogeneous agents exchanging information
Hassan, Taher. "Logistique hospitalière : organisation de la chaîne logistique pharmaceutique aval et optimisation des flux de consommables et des matériels à usage unique". Phd thesis, INSA de Lyon, 2006. http://tel.archives-ouvertes.fr/tel-00378591.
Texto completoBoissière, Julien. "Gestion des stocks dans une chaîne logistique de distribution en coordination avec la production". Grenoble INPG, 2004. http://www.theses.fr/2004INPG0129.
Texto completoInventory management is of major interest for competitiveness in distribution chains. Classical inventory management and lot-sizing studies are done for complex systems but with some strong assumptions. The first of these is that the first logistic stage may obtain whatever quantity immediately from its supplier: we say that this supplier is a perfect supplier. The second assumption is that holding costs are supposed to be non-decreasing as products flow along the chain. This last assumption is clearly true in production systems, but not obviously in distribution systems. This result arises in the first chapter of the thesis. Based on this, we studied serial distribution systems in which we added a supplier and with no assumption on holding costs: a supplier fills a continuous and constant demand through some logistics sites. In the second chapter, we show that in such a system with 3 stages (production-logistics-retailer) integer ratio lot-sizing is very efficient: it is guaranted to be less than 1. 51% more expensive than the optimal lot-sizing. We also propose an upgrade of this guarantee to 0. 5%. In the third chapter, we build up heuristics for getting some lot-sizing policies in a N-stages serial chain. Our results are quite good on average but show a lack of robustness. In the last chapter we investigate the importance of coordination between production and distribution in a 3-levels system. We spot major parameters and study different influence areas of actors
Gros, Marie-Cécile. "Qualification et suivi des appareils de laboratoire : application à une chaîne de dissolution". Bordeaux 2, 1998. http://www.theses.fr/1998BOR2P077.
Texto completoSimonet, Daniel. "Alliances et stratégies de distribution dans l'industrie pharmaceutique : une étude empirique des accords de licence et des partenaires verticaux". Paris 9, 1998. https://portail.bu.dauphine.fr/fileviewer/index.php?doc=1998PA090079.
Texto completoBenjelloun, Kawtar. "Méthodologie de la validation d'un système de production et de distribution d'eaux à usage pharmaceutique". Bordeaux 2, 1997. http://www.theses.fr/1997BOR2P078.
Texto completoPlanells-Rodríguez, Milena. "Modélisation des erreurs en sortie du décodeur dans une chaîne de transmission par satellite". Paris, ENST, 2003. http://www.theses.fr/2003ENST0023.
Texto completoThis dissertation studies the behavior of the errors at the output of the decoder on a satellite communication system. Two different types of channel coding are considered. On one hand, a classical concatenation of a Reed-Solomon with a convolutional code and interleaving. On the other hand, a code from the turbo-codes family. The algorithm used in the convolutional decoding of the first coding system is the maximum likelihood algorithm. It is known that errors at the output of this algorithm are grouped in bursts due to the memory of the code. The group of correct bits between bursts is called a gap. Thus, the output of a maximum likelihood decoder can be modeled by a Markov chain with two states: a first state where no errors take place (good state) and a second state where errors appear in bursts (bad state). Regarding the burst modeling, the previous proposed models did not fit the simulation results for low and average burst lengths. Therefore, we have developed a new model based on the properties of the code that fits the range of all possible bursts lengths. On the second coding system, instead of using a maximum likelihood decoding, iterative decoding based on the successive decoding of each constituent code is considered. These iterative decoding algorithms are based on the Maximum A Posteriori (MAP) principle. This dissertation analyses the behavior of the errors at the output of such iterative decoders and proposes a model that fits quite well with the real errors simulated via Monte Carlo simulations
Beroule, Benoit. "Contribution à l'optimisation de la chaîne logistique pharmaceutique dans un contexte multi-sites : application au groupe hospitalier de la région Mulhouse et sud Alsace". Thesis, Bourgogne Franche-Comté, 2018. http://www.theses.fr/2018UBFCA013/document.
Texto completoThe purpose of this thesis is to study and improve the logistical aspects of the hospitals group named "Groupement Hospitalier de Mulhouse Sud-Alsace" (GHRMSA). Our study focuses on the problematics of the pharmacy of the Emile Muller hospital at Mulhouse in France, which is dedicated to become the central pharmacy of the group. This new consideration implies to centralize several pharmaceutical processes such as the medical devices management which are mandatory for surgical operations. This work is divided into two different parts on the management of surgical devices.Indeed, as a first step we study the optimization of the layout to store surgical devices. The special characteristics of the pharmaceutical environment compared to the industrial one are used to propose methods to design layouts of the warehouse in order to minimize the average distance traveled by the employees during the picking phase. First, we define a linear mathematical model and a dedicated heuristic but also two other methods hybridizing the latter with genetic algorithms and branch and bounds. In order to improve this work and prepare the future, we also propose methods to optimise the routing of the employees to completes endowment lists using a transport vehicle with a multi level storing policy. The use of such a vehicle implies the following constraints: u-turn impossibility, imposed traffic direction and respect of the transport capacity. Any of theses constraints can be considered or not in order to create a model as near as possible of the real world.As a second step, we propose surgical operations scheduling methods. This work focuses on the assignment of the needed surgical devices boxes. The purpose is to improve the decision between the operating theaters of each site of the hospital group and the sterilization service in order to smooth the sterilization workload and to improve the reactivity in case of emergencies or any other unexpected problems. To solve the scheduling problem, we define a linear mathematical model as well as a particle swarm optimization algorithm to create surgical operations plannings which minimize the number of needed surgical devices boxes. Moreover, we extend the initial problem with the transport between hospital locations, and present a method to create plannings for surgical operations and for the delivery of the surgical boxes to minimize the global cost considering the parameters of the transport system
Tabutiaux-Surun, Agnès. "L'évolution du circuit de distribution du médicament : une opportunité de santé publique". Dijon, 1999. http://www.theses.fr/1999DIJOPE02.
Texto completoHabibi, Muhammad Khoirul Khakim. "Optimisation d'une chaîne logistique inverse avec la prise en compte des processus de désassemblage". Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEM005.
Texto completoThis dissertation supports and proposes better management in the implementation of the cir-cular economy by integrating activities of reverse supply chains. The hypothesis states thatintegrating decisions of at least two activities in reverse supply chain leads to better decisionsnotably the collection of End-of-Life products and their disassembly.A deterministic problem, called Collection-Disassembly Problem, integrating both collectionand disassembly processes as well as its formulation are introduced and developed. Due to lackof available instances in the literature, some instances are generated. Another non-integratedformulation is developed and solved using the commercial solver CPLEX. The obtained resultsshow that the integrated model proposes better decisions in terms of total cost. Some ap-proximate methods are developed because the commercial solver CPLEX is unable to provideoptimal solutions under acceptable CPU times notably for large size instances.An extended version of the problem is introduced due to the fact that reverse supply chainsfrequently deal with the uncertainty of certain parameters such as the quality and the quantityof End-of-Life products as well as the demands of components. Also, there is often more thanone vehicle available to collect the products. Thus, this second problem suggested which is calledStochastic Multi-Vehicle Collection-Disassembly Problem and its formulation is developed. Theproblem is formalised as two-stage stochastic programming by assuming that the parametersunder uncertainty follow some known probability distributions and their realisation comes afterthe planning stage. To provide the solutions, two methods combined with an algorithmicframework of Sample Average Approximation are developed.Another problem called Integrated Procurement-Disassembly Problem is also studied. Alongwith the decisions on collection process, this problem emphasises on the decisions of disassemblyline balancing problem
Zingbagba, Mark. "Three essays on Upstream and Downstream Disruptions along Nutritional High-value Food Supply Chains in Emerging Countries". Thesis, Lyon, 2018. http://www.theses.fr/2018LYSES029/document.
Texto completoThis dissertation presents three essays on disruptions along nutritional high-value food supply chains in emerging countries. It extends our understanding of threats to the attainment of food security in emerging countries. With a contribution to agricultural economics, the dissertation relies on value chain, market growth and price transmission theories and applies both panel data and time series econometric techniques to analyse the sources and magnitudes of the disruption of nutritional high-value food chains.The first part of the dissertation examines disruptions in unprocessed and minimally processed nutritional high-value food markets. Chapter 2 examines upstream and downstream disruptions along these food chains. Chapter 3 extends the analysis in Chapter 2 by assessing how disruptions change when nutritional high-value foods are highly processed. For each of the two chapters, disruptions are studied in terms of changes in upstream and downstream quantities and prices, with the disruption of quantity considered primary while that of prices is secondary.Using the São Paulo food market as a case study, Chapter 4 analyses the effect of diesel price shocks on different segments of the nutritional high-value food supply chain. A Vector Error Correction Model (VECM) that takes into account upstream and downstream cross-price effects is estimated to ascertain if diesel price shocks are higher downstream based on price transmission theory.The results of Chapters 2 and 3 show that climatological disasters are the most dominant source of disruption of nutritional high-value food supply chains and the direction of impact is negative for all foods under study. The magnitude of disruption, however, varies by food. From the VECM results in Chapter 4, we see that the price of diesel has a positive and significant effect on food prices, while the effects downstream are lower than those upstream. These results have significant implications for the design and implementation of food policies in emerging countries.As a general introduction, Chapter 1 justifies the need to study upstream and downstream differences in the magnitude of supply chain disruption, by situating the dissertation in the existing supply chain and food price transmission literature. Chapter 5 concludes the study and offers suggestions for future research
Dubedout, Hugues. "Supply chain design and distribution planning under supply uncertainty : Application to bulk liquid gas distribution". Phd thesis, Ecole des Mines de Nantes, 2013. http://tel.archives-ouvertes.fr/tel-00910097.
Texto completoLapassouse-Madrid, Catherine. "Contribution à l'étude des facteurs d'évolution des canaux de distribution : l'exemple des fournitures industrielles". Bordeaux 1, 1989. http://www.theses.fr/1989BOR1D012.
Texto completoThe role of middlemen in distributing industrial products has been greatly developed, to the detriment of direct selling : a solution which is no longer flexible enought to allow the industrials custumers to optimize their supplying costs. This situation is questionning the control that manufacturers have, up to now, exercised over industrial distributors. Due to, on the one hand, an interpretation of channel structures and processes with the aid of the concept of "system value" (proposed by M. E. Porter) and, on the other hand, an empirical survey; the results of this research suggest that industrial distributors may (a model is proposed to describe in which conditions) implement a new strategy of "resistance" to manufacturers. Such behaviors modify the functioning of the channel and are, in the long run, at the origine of a progressive but ineluctable evolution
Nzalakanda, Rufin. "La performativité de la grande entreprise pharmaceutique dans la chaîne de développement des produits de santé : une analyse de la fraude fondée sur le concept de Poche organisationnelle Informelle (P.O.I)". Electronic Thesis or Diss., Paris, HESAM, 2021. https://tel.archives-ouvertes.fr/tel-04164360.
Texto completoSince the 1950s, the pharmaceutical industry is still affected by the scandals of health scandals (thalidomide 1961, 1962 and 1963), Distilbène (1977), Vioxx (2004), Mediator (2009), breast prostheses PIP (2010), ...These are generally health products that have a harmful effect that is not detected earlier in the collective management of these products throughout the health product development chain. These harmful effects have generated disastrous consequences in France and abroad ( some organizations say that these are cases of pain that have caused illness, cancer or death), but also in economic and financial terms (national health costs), image and trust. This is the diagnosis made about the functioning of the pharmaceutical industry. This diagnosis reveals the existence of a dilemma that this sector must undoubtedly resolve. Various situations are often mentioned to refer to this dilemma. Some situations refer to the negligence and imprudence of institutions and organizations for the control and supervision of health products, others are oriented towards the fault and error of the actors involved in the collective management of these products, and others are about fraud perpetrated by actors mandated to develop health products that help the population to eliminate the different diseases. This thesis focuses on situations of fraud committed by big pharma as a research subject. She positions him in the field of white-collar crime, a term invented by American sociologist Edwin. Sutheland in the 1930s). The analysis of this research subject poses a practical question: How big pharma performs to normalize fraud in the health product development chain that includes national, transnational and global levels. It is important to note that this thesis does not aim to stigmatize big pharma, which are essential actors because they contribute to the disappearance of diseases by providing health products to society. Rather, it focuses on a phenomenon that has been clearly identified and that represents a threat to the planet, which has already affected health systems several times, thousands of people in the world and caused considerable human and financial losses. Thus, it relies on the experience of institutional, organizational and individual actors in the health sector, in terms of health scandals marked by pharmaceutical fraud, to answer research questions. The research results show that, big pharma is instrumentalising P.O.I, a structured and structuring organisation, to perform the actors who are involved in the collective management of health products in such a way that their practices and discourse are consistent with what she thinks, says and does. It is through this mechanism that pharmaceutical fraud is normalized at the national, transnational and global levels. More specifically, the P.O.I is a network organisation composed of human and non-human actors.Hidden within the big pharma, it materializes the ability of this enterprise to produce a generalized effect in the process that describes the different phases of realization of a health product, which will encourage the actors involved to legitimize the fraud in order to serve the interests of the entreprise in which it is housed
Benrqya, Yassine. "Product segmentation and distribution strategy selection : an application in the Retail Supply Chain". Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0114/document.
Texto completoNowadays companies must look to develop new distribution strategies in order to achieve the required performance from their supply chain. In this quest, companies wonder about the consistency of their distribution strategies with the products they are selling. Several types of distribution strategies exist in the retail supply chain. These strategies are chosen based on the products characteristics, and/or the impact on the supply chain performances. In this research, we study the impact of three distribution strategies, namely: traditional warehousing, cross-docking pick by line and cross-docking pick by store, on three supply chain performances, namely: service level, cost and bullwhip effect. In addition, we analyse the impact of the products characteristics on the performances of the distribution strategies and propose a framework for choosing the right strategy for each product. The supply chain studied is composed of three echelons: Supplier Distribution Centre, Retailer Distribution Centre and Stores. Based a real business case, we perform a process modelling, that allows us to develop a deterministic Macro cost model and a simulation model. The macro cost model allows to evaluate the impact of the distribution strategies on the supply chain cost performance. After the macro cost analysis, we develop a simulation model where we integrate the data related to the products (demand, volume, ordering quantities etc.) in the model. This model allows a more dynamic simulation of the system in a large time period and determines the right strategy to select for each product depending on its characteristics and the impact on the performances. At the end of this research, we present a framework for product segmentation and distribution strategy selection
Benhamou, Gérard. "Structures de production, de distribution et d'information des médicaments. Un exemple de consommation pharmaceutique : les contraceptifs, application à la Seine-Saint-Denis". Paris 5, 1988. http://www.theses.fr/1988PA05P166.
Texto completoFu, Liangliang. "Coordination d'ordonnancement de production et de distribution". Thesis, Paris 9, 2014. http://www.theses.fr/2014PA090046/document.
Texto completoIn this dissertation, we aim at investigating three supply chain scheduling problems in the make-To-Order business model. The first problem is a production and interstage distribution scheduling problem in a supply chain with a manufacturer and a third-Party logistics (3PL) provider. The second problem is a production and outbound distribution scheduling problem with release dates and deadlines in a supply chain with a manufacturer, a 3PL provider and a customer. The third problem is a production and outbound distribution scheduling problem with setup times and delivery time windows in a supply chain with a manufacturer, a 3PL provider and several customers. For the three problems, we study their individual scheduling problems and coordinated scheduling problems: we propose polynomial-Time algorithms or prove the intractability of these problems, and develop exact algorithms or heuristics to solve the NP-Hard problems. We establish mechanisms of coordination and evaluate the benefits of coordination
Mesmin, Elodie Pouchus Yves-François. "La répartition pharmaceutique française et les bonnes pratiques de distribution en gros des médicaments exemple de la formation aux bonnes pratiques de distribution des membres du service livraison de l'agence CERP Rouen Grand Lille /". [S.l.] : [s.n.], 2006. http://theses.univ-nantes.fr/thesemed/PHmesmin.pdf.
Texto completoLamarche, Andréanne. "Développement d'une méthode de quantification par PCR en temps-réel afin d'étudier la distribution de trois espèces de levures indigènes dans les fromages québécois". Master's thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/35003.
Texto completoThe complex fungal ecosystems of specialty cheeses are increasingly studied because of the potential contribution of indigenous yeasts to the development of the cheese’s sensory properties. They may contribute directly or indirectly by their interaction with the funga l ecosystem or the modification of the cheese matrix. Previous studies detected Cyberlindnera jadinii, Kazachstania servazzii and Pichia k udriavzeviiin both raw milk and/or artisanal specialty cheeses from the province of Québec. The aim of this project was toanalyze the distribution of these three yeast species in cheeses made in the province of Québec. A highly specific and quantitative real time PCR assay was developed to quantitate these yeast species. The rind and the core of cheeses made in the province of Québec were sampled and analyzed using this method. Tracking of C. jadinii and P. k udravzeviirevealed that these yeasts are found within the majority of the analyzed cheeses. This study is the first step toward a better understanding of the possible contribution of these indigenous yeasts species in the development of cheese flavors, and their role in the cheese’s fungal ecosystem.
MEVEL, Olivier. "Du role des signaux faibles sur la reconfiguration des processus de la chaîne d e valeur de l'organisation : l'exemple d'une centrale d'achats de la grande distribution française". Phd thesis, Université de Bretagne occidentale - Brest, 2004. http://tel.archives-ouvertes.fr/tel-00009025.
Texto completoPouessel, Isabelle. "Epidémiologie du médicament". Paris 5, 1988. http://www.theses.fr/1988PA05P202.
Texto completoMargo, Denis. "Les bonnes pratiques de distribution appliquées à l'oxygène médical et au matériel médical". Bordeaux 2, 1999. http://www.theses.fr/1999BOR2P080.
Texto completoPatay, Emmanelle. "Déploiement de la chaîne logistique de l'hydrogène pour le marché des carburants en 2050 : conception et développement d'un outil d'aide à la décision pour l'analyse de scénarios". Châtenay-Malabry, Ecole centrale de Paris, 2008. http://www.theses.fr/2008ECAP1081.
Texto completoThe deployment of a market for hydrogen energy is a new problem, considered by governments, industrials and scientists to meet global targets of greenhouse gases emissions reduction and to ensure security in energy supply. In this context, the optimization problem of scheduling the deployment until 2050 of the hydrogen supply chain for fuel market throughout a country has been the object of our study. We get support of Air Liquide Company, his experience and experts in production and distribution of industrial hydrogen, to build an approach to the problem meeting the requirements of an industrial context. After defining and characterizing the optimization problem through a systemic analysis of the distribution infrastructure, we proposed a method suited to its resolution. Monte Carlo simulations enabled us to develop cost functions. Then we developed a heuristic algorithm for approximate optimization of these cost functions. Our approach has necessitated the definition of simulation rules, a design of experiment and a regression method, as well as a heuristic algorithm adapted to the structure of the problem. The specification, development and use of software tools have helped to validate the chosen methodology for the optimization of the uncertain problem of our study. The scenario of evolution has created a reference to validate the model and provide some analysis for early studies of deployment
Paubel, Pascal. "Achats des produits du domaine pharmaceutique dans les établissements publics de santé : bilan au 30 novembre 2008 des réformes du code des marchés publics : de la tarification à l'activité et de la rétrocession". Lille 2, 2009. http://www.theses.fr/2009LIL20002.
Texto completoFrench public hospitals use for all purchases (works, supplies, services) the rules of public contracts. These procedures were modified in 2001, 2004 and 2006, with consequences for practices of hospitals buyers. This work presents fundamentals principles of procedures for public contracts and the organization of purchases in french public hospitals. The consequences of all procedures described by the directory of 1th August 2006 are analysed for supply of medicines and medical devices. This work presents also different modes of financing for medicines and medical devices after the reform of payments by results and the reform for distribution of medicines to ambulatory patients. Analysis of consequences of these reforms for purchase of medicines is suggested at November 2008
Humbert, Martine. "Influence de la chaîne invariante sur le transport, la distribution intracellulaire et la structure quaternaire des molécules de classe II du CMH murin : etude corrélée à la présentation antigénique". Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX22032.
Texto completoPetit, Gaëlle. "Caractérisation et gestion de la valeur durable dans les chaînes de valeur agroalimentaires. Application au cas d’une chaîne de valeur française de production et distribution de viande de porc". Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLA039/document.
Texto completoIt is now necessary for an agrifood value chain to set-up and develop a coherent sustainability strategy for its various stakeholders and to communicate on the efforts made towards citizens and consumers, in demand for more and more sustainable products. To go beyond the first existing initiatives (specifications, labels, etc.), and effectively increase both their sustainable performance and the perceived quality of their offer, considering new management tools, built jointly between upstream and downstream can be a solution. However, the actors in these chains, with different interests and cultures, have individual visions of sustainability. Therefore, if they want to cooperate in order to improve the sustainable performance of their value chain, they should meet a minimum level of satisfaction for each of them. This work aims to propose new standardized and interoperable management tools for food value chains so that the actors can co-create shared sustainable value and move towards new modes of governance.The experimental context is French pork value chains, whose actors maintain contractual relations and have already tackled joint work on the sustainability of certain products. A first contribution focuses on reflection to build a metric to evaluate the sustainable performance of food value chains. The three following cases are dealing with the possibilities for actors in a food value chain to cooperate on common solutions for sustainability improvement. Contrasted alternative scenarios are compared between them and the results are confronted with the respective expectations of the different actors in the value chain. A fourth section focuses on the importance of standardized data sharing among the various actors to support the sustainable performance. Finally, a final section proposes a support model for participative work in order to facilitate a common strategy definition for sustainability
Pavero, Catherine. "Absorption intestinale chez le rat des acides gras à longue chaîne monoinsaturée (acides oléique et érucique) et polyinsaturés (acides arachidonique et eicosapentaenoique) : répartition chyloportale, métabolisme intraentérocytaire, distribution des lipoprotéines intestinales". Dijon, 1990. http://www.theses.fr/1990DIJOS012.
Texto completoKazemi, Ali. "Etude des relations entre les dimensions de la qualité de service du point de vente, l'image de l'enseigne, la satisfaction des clients et la fidélité : un modèle pour une chaîne de distribution iranienne". Thesis, Bordeaux 4, 2011. http://www.theses.fr/2011BOR40063/document.
Texto completoToday, the most successful corporate image in the world are retailing and chain stores. Most chainstores and retailing companies have research programs designed to measure Point of Sale (Store),Customer Satisfaction (Experience), Brand Image (Corporate Image) and Quality of relationship.Such programs are designed to allow management to measure store (POS) constructs and relationswith corporate image, satisfaction, quality of relationship and store loyalty. This constructs provideessential information to guide efforts to increase the excellent variability in stores and will help toensure there continued loyalty and patronage. There is evidence as to the link between store qualityand excellence chain store performance and chain store –level data suggests as link between higherstore quality, higher corporate image, higher customer satisfaction, higher loyalty and improved themarket share, customer share and profitability.The survey effect of Store Quality Dimensions as a POS toward Customer Satisfaction and LoyaltyDimensions, to creating the loyal customers is one of the most important in literature of this thesis.There have been different but homogenous approach for considering research constructs. Thecustomer - based approach, the financial approach and combination approach. While this studyfocus on customer approach and survey the effective process of “SQD ---CS---LD path” in chainstore industry.This constructs used to operationalization of customer loyalty as target objective of model .we usedthe store quality as an antecedent of customer satisfaction and customer loyalty and called “SQDbased-LD” approach. The contribution of this study is formulating and development of aconceptual framework that integrates the constructs of model and extraction of SQD – LD Modelin Iran chain stores
Li, Rui. "Le management de la distribution multicanal : comprendre et analyser le phénomène d'intégration : le cas de la société Nestlé". Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0159.
Texto completoIn the contemporary context of rapidly evolving distribution and e-commerce, this research investigates a general problem articulated around the topic of multichannel distribution. We are particularly interested in the phenomenon of multichannel integration and lay emphasis on the major significance of an overall vision when a company tries to manage its different distribution channels. While adopting a BtoB approach and a business management perspective, this academic work tries to address a central question: how can industrial companies integrate their multiple distribution channels? The answers are provided by a qualitative approach based on an in-depth case study in Nestlé France. The findings of this research suggest a series of endogenous and exogenous factors that influence the level of multichannel integration obtained by a company. Some of those factors, which are associated with the relational coordination across the logistics, marketing and information system departments, could be regarded as a strongly expected dimension for the company under study to establish the multichannel integration procedures. Furthermore, the adoption of multichannel integration appears to create a positive influence on the perceived performance of the company. Some challenges met in terms of estimating the impacts of integration are also identified. Finally, the results indicate that the studied company is probably not attempting to reach the extreme level of multichannel integration. It would be more interesting to reach a satisfactory level and find the point of balance between too much and not enough integration by reinforcing the current advantages of multichannel integration
Chahed, Jebalia Salma. "Modélisation et analyse de l'organisation et du fonctionnement des structures d'hospitalisation à domicile". Phd thesis, Ecole Centrale Paris, 2008. http://tel.archives-ouvertes.fr/tel-00275799.
Texto completoDans ce travail de recherche, l'intérêt est porté sur les établissements d'hospitalisation à domicile (HAD) en raison du paradoxe qui les caractérisent : bien que créés il y a une cinquantaine d'années, ces établissements se sont révélées, durant cette dernière décennie, comme moyen possible de réduction des dépenses du domaine de la santé tout en satisfaisant une bonne qualité de service. En outre, à la différence des établissements hospitaliers, les problématiques existantes dans les établissements d'HAD n'aiguisent pas suffisamment la curiosité de la communauté du génie industriel en général et celle de la recherche opérationnelle en particulier.
Dans cette thèse, nous nous intéressons à trois problématiques distinctes issues du domaine d'HAD. La première concerne l'activité principale des professionnels de santé à savoir la gestion des projets thérapeutiques des patients. Une extension du projet thérapeutique est présentée permettant d'intégrer l'aspect organisationnel des prestations de soins fournissant ainsi un outil d'aide à la coordination des acteurs impliqués dans la prise en charge des patients. A partir de cette étape, il nous a été possible d'avoir une vision multi-projets, et de modéliser de la sorte l'ensemble des fonctions de type gestion des opérations propres à un établissement d'HAD. Cette modélisation émane en partie d'une étude comparative entre quatre établissements d'HAD. En se basant sur les principales fonctions identifiées, une cartographie des décisions est dressée adoptant différents niveaux d'horizons temporels. Cette visibilité sur le système décisionnel nous a éclairé quant aux problématiques critiques intéressant les établissements d'HAD. La dernière problématique porte sur la production et la distribution des médicaments anticancéreux dans le cadre d'une chimiothérapie à domicile. Le problème s'apparente à un problème du voyageur de commerce couplé à un problème d'ordonnancement.
Garnier-Laplace, Jacqueline. "Etude des mécanismes de transfert de l'argent 110-m en eau douce : conception et exploitation d'un modèle expérimental d'écosystème et d'un modèle mathématique de simulation de la distribution du radioélément au sein d'une chaîne trophique". Montpellier 2, 1990. http://www.theses.fr/1990MON20225.
Texto completoCharlou, Christophe. "Caractérisation et modélisation de l’écoulement de boues résiduaires dans un sécheur à palettes". Thesis, Ecole nationale des Mines d'Albi-Carmaux, 2014. http://www.theses.fr/2014EMAC0004/document.
Texto completoDrying is an unavoidable operation prior to sludge valorization in incineration, pyrolysis or gasification. The flexibility to adapt the solid content of the dried sludge to the demand is a major requirement of any drying system. This objective is difficult to reach for paddle dryers. Modeling the process is thus essential. Unfortunately, sludge rheological behavior is complex and computational fluid dynamics is out of reach for the time being. The concept of Residence Time Distribution (RTD) is used here to investigate sludge flow pattern in a paddle dryer. A reliable and reproducible protocol was established and implemented on a lab-Scale continuous dryer. Pulse injections of titanium oxide and of salt metals, with X-Ray fluorescence spectroscopy as detection method, were used to characterize the RTD of anhydrous solid and wet sludge, respectively. Premixing the pasty sludge, for tracer powder dispersion for instance, changes the structure of the material. This was highlighted through the measurements of particle size distributions and characterization of rheological properties. However, drying experiments performed in batch emphasized that premixing does not have any influence on the kinetic and the sticky phase. The RTD curves of the anhydrous solid are superimposed on those of the moist sludge. Consequently, a simpler protocol, based on pulse injection of chloride sodium and offline conductivity measurements, was established. Easier to implement in industry and cheaper, this method proves to be as reliable as the first one. The influence of storage duration prior to drying was assessed. The mean residence time doubles when the storage duration changes from 24h to 48h. Finally, a model based on the theory of Markov chains has been developed to represent the RTD. The flow of anhydrous solids is described by a chain of n perfectly mixed cells, n corresponding to the number of paddles. The transition probabilities between the cells are governed by two parameters: the ratio of internal recirculation, R, and the solids hold-Up, MS. R is determined from the Van der Laan's relation and MS is identified by fitting the model to the experimental RTD. The model describes the flow pattern with a good accuracy. The computed hold-Up is lower than the experimental one. Part of the sludge is stuck to the walls of the dryer, acting as dead volumes in the process
Arimatsu, Yui. "Communautés locales de l’âge du Fer dans l’Iran septentrional : variation régionale de la forme, de la chaîne opératoire et de la fonction de la céramique non-utilitaire". Thesis, Lyon 2, 2011. http://www.theses.fr/2011LYO20022/document.
Texto completoAnalyzing the material from a mountainous region of northern Iran, we investigate the image of a local society during the Iron Age (Late 2nd - late 1st millennium B.C.). Although the peculiarities of the material culture of that region have been recognized since long, there are not enough comprehensive studies on the material culture, chronology, and precise representations of the societies.For this purpose, we deal with old data, some published other unpublished, as well as new material including a lot of unpublished ones that we have studied in Iran and Japan. Four main topics are treated: chronology, change and regional diversity of pottery, evolution of practices, and distribution of sites. Based on the results of these analyses and on the methodological framework and working hypotheses deriving from the results of ethnology, ethno-archaeology and sociology, we try to interpret the peculiar ceramics and the funerary practices, which are considered as representative of the material culture of Northern Iran, as well as the social organization which permitted to maintain the relationship between the populations who fluidly and dispersed lived in that area which presents various geographic conditions. Finally, one concludes that the social organization did not structure in local society in a stable manner.In the second half of the Iron Age, we can consider that, with the penetration of the new symbolic order, the local society which lived under varied natural conditions, modes of occupation and habitation and technical traditions have changed. During the same period, with the evolution of funeral practices towards simplicity, practices in public spaces and buildings extended over the region. In northern Iran, the Iron Age historically corresponds to the time of these structural changes in local society
Pan, Shenle. "Contribution à la définition et à l'évaluation de la mutualisation de chaînes logistiques pour réduire les émissions de CO2 du transport : application au cas de la grande distribution". Phd thesis, Paris, ENMP, 2010. https://pastel.hal.science/pastel-00566265.
Texto completoThis research aims to define and assess the performance of a different logistics organization: the pooling of supply chains. It implies to design a pooled logistics network within several companies by sharing logistics resources (warehouses, distribution centers, transportation means, etc. ) and logistics systems, in order to improve supply chains' logistics performance. The performance of this new logistics organization was assessed by two criteria: primarily the environmental criteria measured by the CO2 emissions from transport and secondly economic consequences measured by the logistics cost. The difference between environment optimization and economic optimization was also examined. Two cases study were conducted in collaboration with French logistical organizations (Club Demeter and FEEF), respectively based on the major food suppliers and the small and medium food suppliers of the fast moving consumer goods in France. The optimization models for transport optimization aiming to minimize CO2 emissions or logistics cost were formalized and implemented in order to design pooled networks. The results obtained show that the pooling supply chains lead to a significant reduction in CO2 emissions from transport: between -20% and -50% according to the cases studied. The economic performance is less remarkable, but also often more beneficial than the current situation. This performance depends in particular on the relative evolution of transportation costs between rail and road. For example, carbon taxation could allow a better transport allocation from an environment and an economic standpoint
Pan, Shenle. "Contribution à la définition et à l'évaluation de la mutualisation de chaînes logistiques pour réduire les émissions de CO2 du transport : application au cas de la grande distribution". Phd thesis, École Nationale Supérieure des Mines de Paris, 2010. http://pastel.archives-ouvertes.fr/pastel-00566265.
Texto completoRenaud, Jeremy. "Amélioration de la prédiction des commandes des pharmacies auprès de la CERP RRM". Electronic Thesis or Diss., Bourgogne Franche-Comté, 2024. http://www.theses.fr/2024UBFCD010.
Texto completoThe CERP Rhin Rhone Mediterranée (CERP RRM) is a wholesale distributor responsible for ensuring pharmacies' supply. Despite recent advancements in hospital logistics, the pharmaceutical sector notably lacks decision support tools. The thesis aims to establish a predictive system for all CERP clients to forecast orders with the highest possible accuracy. The data primarily consists of time series.Initially, the thesis focused on conducting a state-of-the-art review of time series prediction technologies, as well as implementing AI systems in industrial sectors related to wholesale distribution professions. The main contribution of this thesis was to enhance CERP RRM predictions at multiple levels using machine learning techniques. Our results demonstrate an improvement in predictions compared to the current method. The second contribution was to propose a new method based on sales curve analysis to group products together. This method was developed to address the issue of grouping parapharmacy products within CERP RRM. The final contribution of this thesis is a comparative study of different natural language processing models implemented in a conversational assistant for the technical service of a pharmacy management software. This solution has shown promising results, approaching those of an expert human
Nsamzinshuti, Alexis. "Développement et application d'un modèle intégré d'analyse de la performance des chaînes logistiques de l’agribusiness". Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/263601.
Texto completoDoctorat en Sciences de l'ingénieur et technologie
info:eu-repo/semantics/nonPublished
Koukpo, Rachel Sainhoundé. "Le droit des produits de santé en Afrique de l'Ouest : le cas du Bénin et du Sénégal". Thesis, Bordeaux 4, 2012. http://www.theses.fr/2012BOR40008/document.
Texto completoDrugs are a particular consumer product having a multiple purposes. Specific goods carryrisks in themselves, and shouldn’t be distributed solely to the mainstream market. Rather, theymust be evaluated before, during and after their commercial life. Active products arenecessary for healthcare, but contain numerous risks. The entire cycle (production, delivery,recovery) of all health products must be very strictly supervised and entrusted to aprofessional’s responsibility. Their supervision therefore requires the attention of the wholehealth care community, and must be strictly regulated because health problems can resultfrom misuse. These features of the drug involve a certain codification system. Regulatoryrequirements govern the place on the market and use of these assets to ensure their quality,effectiveness and safety. Medical malpractice is not always well supervised in the medicaland hospital atmosphere of Africa. And in case of damage to health resulting from misuse, itis important to consider the rights and responsibilities of the various people involved(healthcare professionals, patients, government). Medical errors cannot be prevented if theculture of risk and responsibility is not instilled in the minds of the public. This is aprerequisite for the reorganisation of the distribution of health products
Amouric, Jane. "La distribution officinale du médicament à l'épreuve de l'européanisation et de la globalisation : une étude au travers de trois exemples : la France, l'Angleterre et l'Italie". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM1007/document.
Texto completoEuropean influence, especially political and legal, the globalisation of drug trade as well as the consequences of the globalisation of health, economic and financial crises impact the organisation and practice of French, Italian and English retail pharmacy. Convergence is generally presented as one of the possible consequences of europeanisation and globalisation. In effect, are the legal regimes of drug distribution in retail pharmacies in France, Italy and England evolving towards a common « legal model », beyond their historical opposition ? In reality, not only are we witnessing the emergence of organisational and operational retail pharmacy legal models that do not carry a unicity that would enable significantly reducing differences between national legislations, but this unicity would not be timely. Indeed, the preservation of national specificities, as well as the adaptation of regulations to national contexts appear as key guarantors of the efficacy of retail pharmacy drug distribution national legal regimes. However, the efficacy of regulations cannot be summarised to guaranteeing the sector’s national specificities, as illustrated by the obstacles to compensation for damages attributable to medicines and to the protection of the pharmaceutical monopoly. While some of these obstacles appear precisely linked to national characteristics, others relate specifically to the war against illegal drug sales
Wang, Deyun. "Integrated Scheduling of Production and Transportation Operations with Stage-dependent Inventory Costs and Due Dates Considerations". Phd thesis, Université de Technologie de Belfort-Montbeliard, 2012. http://tel.archives-ouvertes.fr/tel-00720660.
Texto completoCasse, Jérôme. "Automates cellulaires probabilistes et processus itérés ad libitum". Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0248/document.
Texto completoThe first part of this thesis is about probabilistic cellular automata (PCA) on the line and with two neighbors. For a given PCA, we look for the set of its invariant distributions. Due to reasons explained in detail in this thesis, it is nowadays unthinkable to get all of them and we concentrate our reections on the invariant Markovian distributions. We establish, first, an algebraic theorem that gives a necessary and sufficient condition for a PCA to have one or more invariant Markovian distributions when the alphabet E is finite. Then, we generalize this result to the case of a polish alphabet E once we have clarified the encountered topological difficulties. Finally, we calculate the 8-vertex model's correlation function for some parameters values using previous results.The second part of this thesis is about infinite iterations of stochastic processes. We establish the convergence of the finite dimensional distributions of the α-stable processes iterated n times, when n goes to infinite, according to parameter of stability and to drift r. Then, we describe the limit distributions. In the iterated Brownian motion case, we show that the limit distributions are linked with iterated functions system