Literatura académica sobre el tema "Ceramidase"
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Artículos de revistas sobre el tema "Ceramidase"
Yuan, Changqing, Raghavendra Pralhada Rao, Nahid Jesmin, Takeshi Bamba, Kunio Nagashima, Alberto Pascual, Thomas Preat, Eiichiro Fukusaki, Usha Acharya y Jairaj K. Acharya. "CDase is a pan-ceramidase in Drosophila". Molecular Biology of the Cell 22, n.º 1 (enero de 2011): 33–43. http://dx.doi.org/10.1091/mbc.e10-05-0453.
Texto completoDuarte, Carolina, Juliet Akkaoui, Chiaki Yamada, Anny Ho, Cungui Mao y Alexandru Movila. "Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration". Cells 9, n.º 6 (2 de junio de 2020): 1379. http://dx.doi.org/10.3390/cells9061379.
Texto completoParveen, Farzana, Daniel Bender, Shi-Hui Law, Vineet Kumar Mishra, Chih-Chieh Chen y Liang-Yin Ke. "Role of Ceramidases in Sphingolipid Metabolism and Human Diseases". Cells 8, n.º 12 (4 de diciembre de 2019): 1573. http://dx.doi.org/10.3390/cells8121573.
Texto completoJin, K., Y. Higaki, Y. Takagi, K. Higuchi, Y. Yada, M. Kawashima y G. Imokawa. "Analysis of beta-glucocerebrosidase and ceramidase activities in atopic and aged dry skin." Acta Dermato-Venereologica 74, n.º 5 (1 de septiembre de 1994): 337–40. http://dx.doi.org/10.2340/0001555574341343.
Texto completoRamachandra, Nagaraju y Andreas Conzelmann. "Membrane topology of yeast alkaline ceramidase YPC1". Biochemical Journal 452, n.º 3 (31 de mayo de 2013): 585–94. http://dx.doi.org/10.1042/bj20130085.
Texto completoZaibaq, Faris, Tyrone Dowdy y Mioara Larion. "TMET-36. ACID CERAMIDASE INHIBITION EXPLOITS SPHINGOLIPID VULNERABILITIES IN IDH MUTANT GLIOMAS". Neuro-Oncology 24, Supplement_7 (1 de noviembre de 2022): vii269—vii270. http://dx.doi.org/10.1093/neuonc/noac209.1041.
Texto completoProksch, Denny, Jan Jasper Klein y Christoph Arenz. "Potent Inhibition of Acid Ceramidase by Novel B-13 Analogues". Journal of Lipids 2011 (2011): 1–8. http://dx.doi.org/10.1155/2011/971618.
Texto completoYi, Jae Kyo, Ruijuan Xu, Lina M. Obeid, Yusuf A. Hannun, Michael V. Airola y Cungui Mao. "Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases". PLOS ONE 17, n.º 9 (1 de septiembre de 2022): e0271540. http://dx.doi.org/10.1371/journal.pone.0271540.
Texto completoOlsson, Maria, Rui-Dong Duan, Lena Ohlsson y Åke Nilsson. "Rat intestinal ceramidase: purification, properties, and physiological relevance". American Journal of Physiology-Gastrointestinal and Liver Physiology 287, n.º 4 (octubre de 2004): G929—G937. http://dx.doi.org/10.1152/ajpgi.00155.2004.
Texto completoBIONDA, Clara, Jacques PORTOUKALIAN, Daniel SCHMITT, Claire RODRIGUEZ-LAFRASSE y Dominique ARDAIL. "Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?" Biochemical Journal 382, n.º 2 (24 de agosto de 2004): 527–33. http://dx.doi.org/10.1042/bj20031819.
Texto completoTesis sobre el tema "Ceramidase"
Bayerle, Aline [Verfasser]. "Physiologische Konsequenzen eines gestörten Ceramid Stoffwechsels unter Beteiligung von Ceramidsynthase 3 und saurer Ceramidase = Physiological consequences of a disturbed ceramide metabolism due to altered activities of ceramide synthase 3 and acidic ceramidase / Aline Bayerle". Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2015. http://d-nb.info/1225685362/34.
Texto completoGoltz, Gerit. "Charakterisierung von Ceramidase-Inhibitoren an der humanen Keratinozyten-Zellinie HaCaT". [S.l.] : [s.n.], 2002. http://www.diss.fu-berlin.de/2002/180/index.html.
Texto completoLucki, Natasha Chrystman. "Characterization of the role of acid ceramidase in adrenocortical steroid hormone biosynthesis". Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42804.
Texto completoLi, Guangbi. "Podocyte Dedifferentiation and Glomerular Injury Mediated by Lysosome Dysfunction: Role of Acid Ceramidase". VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5169.
Texto completoCamacho, Castillo Luz del Carmen. "Acid ceramidase and sphingosine-1-phosphate lyase as biomarkers and therapeutic targets in cancer. (Ceramidasa ácida y Esfingosina-1-fosfato Liasa como biomarcadores y dianas terapéuticas en cáncer)". Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/21624.
Texto completoMarkus, Carolin [Verfasser]. "Die Funktion der putativen alkalischen Ceramidase ACER1 innerhalb des Sphingolipidstoffwechsels in Arabidopsis thaliana / Carolin Markus". Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1080864571/34.
Texto completoFuchs, Kathrin [Verfasser] y Johannes [Akademischer Betreuer] Kornhuber. "Charakterisierung der Ceramidase-Aktivität im Plasma gesunder und alkoholabhängiger Probanden / Kathrin Fuchs. Gutachter: Johannes Kornhuber". Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2014. http://d-nb.info/1075478774/34.
Texto completoMeiners, Jana [Verfasser] y Astrid [Akademischer Betreuer] Westendorf. "The effect of the acid sphingomyelinase/ceramidase system on bacterial induced colitis / Jana Meiners ; Betreuer: Astrid Westendorf". Duisburg, 2019. http://d-nb.info/1191692159/34.
Texto completoDrosos, Zacharias [Verfasser], Lars [Akademischer Betreuer] Hanker y Markus [Akademischer Betreuer] Meier. "Die prognostische Bedeutung der Expression von Acid-Ceramidase (ASAH1) und Sphingosin-Kinase 1 (SPHK1) bei Patientinnen mit Ovarialkarzinom / Zacharias Drosos ; Akademische Betreuer: Lars Hanker, Markus Meier". Lübeck : Zentrale Hochschulbibliothek Lübeck, 2021. http://d-nb.info/1236386272/34.
Texto completoYamakawa, Nathália Christina Gonçalves 1986. "Epilepsia e Morita-Baylis-Hillman : uma abordagem sintética para ceramidas antiepiléticas". [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250239.
Texto completoDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química
Made available in DSpace on 2018-08-21T16:21:23Z (GMT). No. of bitstreams: 1 Yamakawa_NathaliaChristinaGoncalves_M.pdf: 16524766 bytes, checksum: 72cb2d423e322cd66bf985a8a162ae5a (MD5) Previous issue date: 2012
Resumo: A epilepsia é uma das principais doenças do sistema nervoso central, caracterizada por uma alteração na atividade elétrica do cérebro, que leva a perdas de memória e convulsões. Essa doença afeta cerca de 50 milhões de pessoas no mundo, que são discriminadas e isoladas da sociedade. Existem vários medicamentos que podem ser utilizados, no entanto, muitas vezes é necessário a administração de associações desses que apresentam severos efeitos colaterais. Esse quadro justifica a necessidade da busca por substâncias mais eficientes para o tratamento dessa doença. Em 2008, Ahmed e cols. isolaram da esponja marinha Negombata corticata duas ceramidas que apresentaram importante atividade anti-convulsiva. Assim, este trabalho teve por objetivo estabelecer uma estratégia sintética para a preparação do fragmento polar de tais ceramidas. A rota foi baseada em um aduto de Morita-Baylis-Hillman (MBH), obtido com elevada diastereosseletividade a partir de uma reação entre o aldeído de Garner e o acrilato de etila. Uma reação de ozonólise na dupla ligação do aduto de MBH fornece um a-cetoéster, cuja carbonila cetônica e reduzida conduzindo a um único produto. A proteção das hidroxilas, permitiu a confirmação da estereoquímica relativa através de análise por difração de raios-X, que também evidenciou a ocorrência de racemização na reação de MBH. O diol também foi utilizado na preparação de um aza-açúcar, potencial inibidor de glicosidase, sendo esta síntese em apenas 4 etapas com 32% de rendimento global. A fração apolar da ceramida foi sintetizada a partir de uma reação de Grignard, e a junção dos fragmentos pode ser realizada utilizando-se uma reação de Wittig. Desta maneira, foi descrita uma nova estratégia sintética que pode ser aplicada na preparação de diversos análogos das ceramidas, desenvolvendo um antiepiléptico mais potente
Abstract: Epilepsy is a chronic brain disorder that affects around 50 million people all over the world. It is characterized by recurrent seizures - which are physical reactions to sudden excessive electrical discharges in a group of brain cells. The discrimination and social stigma that surround epilepsy worldwide are often more difficult to overcome than the seizures themselves. Because of this fact and the economical impacts of the disease, the research for new biologically active compounds is still necessary. In 2008, Ahmed et al. isolated from the Red Sea sponge Negombata corticata two ceramides, which exhibit in vivo anticonvulsant activity. This work is focused on establishing of a synthetic sequence to prepare the polar fragment present in both ceramides. The strategy was based on a Morita-Baylis-Hillman reaction between a Garner¿s aldehyde and ethyl acrylate that provided a functionalized intermediate in good diastereoselectivity. The major diastereoisomer was employed as substrate in an ozonolysis reaction, followed by a stereoselective reduction that afforded 1,2-diol as a single isomer. The acetonide derived from this 1,2-diol allowed us to determine through X-Ray diffraction analysis the relative stereochemistry of this compound as being 1,2- anti. To finish the synthesis of the polar fragment, the ester group present in the acetonide was reduced to the corresponding aldehyde. The diol also was applied in a high diastereoselective preparation of an azasugar in 4 steps and 32% yield overall. In this work we also describe the synthesis of a carbon chain of the ceramide, our route includes an approach to the apolar fragment obtained by a Grignard reaction; then a Wittig reaction can couple both fragments toward the finalization of the sphingosine¿s synthesis. Our synthetic route can also be used in the preparation of several analogues of the antiepiletic ceramides
Mestrado
Quimica Organica
Mestre em Química
Libros sobre el tema "Ceramidase"
Futerman, Anthony H., ed. Ceramide Signaling. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4419-9272-7.
Texto completoStiban, Johnny, ed. Bioactive Ceramides in Health and Disease. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-21162-2.
Texto completoBaker, Alison Dawn. Role of ceramide in induction of Fos, Jun, and collagenase in chondrocytes. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1999.
Buscar texto completoSedel, Frédéric. Krabbe Disease in Adults. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0051.
Texto completoH, Futerman Anthony, ed. Ceramide signaling. Georgetown, Tex. U.S.A: Landes Bioscience/Eurekah.com, 2002.
Buscar texto completoFuterman, Anthony H. Ceramide Signaling. Springer, 2012.
Buscar texto completoFuterman, Anthony H. Ceramide Signaling. Springer, 2003.
Buscar texto completoOverloop, Helena Van. Metabolism & Biological Activities of C(2)-ceramide. Leuven Univ Pr, 2006.
Buscar texto completoSummers, Scott A. y William Louis Holland, eds. The Role of Ceramides in Diabetes and Cardiovascular Disease. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88966-736-9.
Texto completoWatkins, Cecilia L. Sphingomyelin and Ceramides: Occurrence, Biosynthesis and Role in Disease. Nova Science Publishers, Incorporated, 2015.
Buscar texto completoCapítulos de libros sobre el tema "Ceramidase"
Tani, Motohiro y Makoto Ito. "Neutral Ceramidase". En Encyclopedia of Signaling Molecules, 3450–57. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101723.
Texto completoTani, Motohiro y Makoto Ito. "Neutral Ceramidase". En Encyclopedia of Signaling Molecules, 1–8. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101723-1.
Texto completoScharnagl, Hubert, Winfried März, Markus Böhm, Thomas A. Luger, Federico Fracassi, Alessia Diana, Thomas Frieling et al. "Acid Ceramidase Deficiency". En Encyclopedia of Molecular Mechanisms of Disease, 12. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8522.
Texto completoMckay, Charles P. "Ceramidase and Signal Transduction". En Sphingolipid-Mediated Signal Transduction, 173–81. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-662-22425-0_12.
Texto completoNorris, James S., David H. Holman, Marc L. Hyer, Alicja Bielawska, Ahmed El-Zawahry, Charles Chalfant, Charles Landen et al. "Ceramide, Ceramidase, and FasL Gene Therapy in Prostate Cancer". En Death Receptors in Cancer Therapy, 323–38. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-851-x:323.
Texto completoIto, Makoto, Nozomu Okino, Motohiro Tani, Susumu Mitsutake y Katsuhiro Kita. "Molecular Evolution of Neutral Ceramidase: From Bacteria to Mammals". En Ceramide Signaling, 41–48. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4419-9272-7_5.
Texto completoMao, Cungui y Lina Obeid. "Ceramidases: Regulators of Turnover of Ceramide and Ceramide-Mediated Responses". En Ceramide Signaling, 29–40. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4419-9272-7_4.
Texto completoIto, Makoto, Motohiro Tani y Yukihiro Yoshimura. "Neutral Ceramidase as an Integral Modulator for the Generation of S1P and S1P-Mediated Signaling". En Sphingolipid Biology, 183–96. Tokyo: Springer Japan, 2006. http://dx.doi.org/10.1007/4-431-34200-1_13.
Texto completoEl Bawab, Samer, Cungui Mao, Lina M. Obeid y Yasuf A. Hannun. "Ceramidases in the Regulation of Ceramide Levels and Function". En Subcellular Biochemistry, 187–205. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/0-306-47931-1_10.
Texto completoNikolova-Karakashian, Mariana, Teresa R. Vales, Elaine Wang, David S. Menaldino, Christopher Alexander, Jane Goh, Dennis C. Liotta y Alfred H. Merrill. "Ceramide Synthase and Ceramidases in the Regulation of Sphingoid Base Metabolism". En Sphingolipid-Mediated Signal Transduction, 159–72. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-662-22425-0_11.
Texto completoActas de conferencias sobre el tema "Ceramidase"
Flowers, Margaret, Gemma Fabriás, Antonio Delgado, Josefina Casas y Myles C. Cabot. "Abstract 5484: Targeted inhibition of acid ceramidase and C6-ceramide exposure induces synergistic killing in cancer cells". En Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-5484.
Texto completoTurner, Lorianne S., Stephen Dungee, Frank Pezzimenti y Margot Weatherford. "Abstract 4894: Effect of lysosome destabilization on response to ceramide in prostate cancer cells over-expressing acid ceramidase". En Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4894.
Texto completoSebti, Said M., Norbert Berndt, Ronil Patel, Hua Yang y Maria Balasis. "Abstract 4522: Akt2 and acid ceramidase cooperate to induce malignant transformation". En Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4522.
Texto completoPearson, Jennifer M., Su-Fern Tan, Arati Sharma, Todd E. Fox, Jose Luis Abad, Gemma Fabrias, David F. Claxton, David J. Feith, Mark Kester y Thomas P. Loughran. "Abstract 48: Acid ceramidase inhibition: A targeted therapy for acute myeloid leukemia". En Abstracts: Second AACR Conference on Hematologic Malignancies: Translating Discoveries to Novel Therapies; May 6-9, 2017; Boston, MA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3265.hemmal17-48.
Texto completoTani, Motohiro, Hiroshi Iida y Makoto Ito. "O-GLYCOSYLATION OF MUCIN-LIKE DOMAIN RECRUITS RAT NEUTRAL CERAMIDASE TO OUTER LEAFLETS OF PLASMA MEMBRANE". En XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.563.
Texto completoTan, Su-Fern, Xin Liu, Kenichiro Doi, Hong-Gang Wang, Myles Cabot, David Feith y Thomas P. Loughran. "Abstract 761: Acid ceramidase promotes drug resistance in acute myeloid leukemia through P-gp upregulation mediated by NF- kB activation". En Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-761.
Texto completoLezhniova, Vera Runarovna, Ekaterina Vladimirovna Martynova, Timur Il'dusovich Khaibullin, Ilnur Il'dusovich Salafutdinov, Mariia Ivanovna Markelova, Aleksandr Vladimirovich Laikov, Leonid Valentinovich Lopukhov y Svetlana Frantsevna Khaibullina. "Seasonal changes in serum metabolite and cytokine levels in Multiple Sclerosis". En All-Russian scientific conference with International Participation. Publishing house Sreda, 2022. http://dx.doi.org/10.31483/r-102302.
Texto completoHanker, Lars, Ahmed El-Balat, Thomas Karn, Uwe Holtrich, Benedikt Decker, Jacobus Pfisterer, Heide Gevensleben y Stefan Kommoss. "EP222/#606 Acid ceramidase (ASAH1) expression is associated with improved overall survival in patients with high-grade serous ovarian cancer from the ICON-7 trial". En IGCS 2022 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-igcs.313.
Texto completoHanker, Lars Christian, Ahemd El-Balat, Thomas Karn, Uwe Holtrich, Bendickt Decker, Jakobus Pfisterer, Heide Gevensleben y Stefan Kommoss. "2022-RA-906-ESGO Acid ceramidase(ASAH1)expression is associated with improved progression- and overall survival in high-grade serous ovarian cancer patients". En ESGO 2022 Congress. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-esgo.589.
Texto completoWann, Daniel, Victoria Palau, Janet Lightner, Marianne Brannon, William Stone y Koyamangalath Krishnan. "Abstract 4639: Metformin decreases cellular ceramides in MCF-7 and MDA-MB 231 breast cancer cell lines by inhibition of ceramide synthetic enzymes". En Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4639.
Texto completoInformes sobre el tema "Ceramidase"
Beckham, Thomas H. Evaluation of Acid Ceramidase Overexpression-Induced Activation of the Oncogenic Akt Pathway in Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, enero de 2014. http://dx.doi.org/10.21236/ada600484.
Texto completoAlonso, Alicia. Ceramidas: no sólo en las cremas de belleza. Sociedad Española de Bioquímica y Biología Molecular (SEBBM), marzo de 2015. http://dx.doi.org/10.18567/sebbmdiv_anc.2015.03.2.
Texto completoMomchilova, Albena, Rumiana Tzoneva, Tania Markovska, Mariana Hadzhilazova, Liliana Maslenkova y Roumen Pankov. Genistein Alters Ceramide Levels in A549 Lung Adenocarcinoma Cells. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, julio de 2020. http://dx.doi.org/10.7546/crabs.2020.07.08.
Texto completoWang, Hongtao y Myles C. Cabot. Characterization of the Contribution of Ceramide to Chemotherapy Sensitization in Breast Cancer Cells. Fort Belvoir, VA: Defense Technical Information Center, septiembre de 2001. http://dx.doi.org/10.21236/ada398144.
Texto completoWang, Hongtao y Myles C. Cabot. Characterization of the Contribution of Ceramide to Chemotherapy Sensitization in Breast Cancer Cells. Fort Belvoir, VA: Defense Technical Information Center, septiembre de 2002. http://dx.doi.org/10.21236/ada410271.
Texto completoHansen, Peter J. y Zvi Roth. Use of Oocyte and Embryo Survival Factors to Enhance Fertility of Heat-stressed Dairy Cattle. United States Department of Agriculture, agosto de 2011. http://dx.doi.org/10.32747/2011.7697105.bard.
Texto completoHansen, Peter J. y Amir Arav. Embryo transfer as a tool for improving fertility of heat-stressed dairy cattle. United States Department of Agriculture, septiembre de 2007. http://dx.doi.org/10.32747/2007.7587730.bard.
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