Tesis sobre el tema "Catalabolisme de la proline"
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Zheng, Yao. "Identification of interacting mitochondrial enzymes involved in pyrroline-5-carboxylate metabolism in Arabidopsis thaliana". Electronic Thesis or Diss., Sorbonne université, 2021. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2021SORUS269.pdf.
Texto completoThe proteinogenic amino acid proline plays a crucial role for cellular metabolism in living organisms. In mitochondria, proline is oxidized to glutamate by the sequential action of proline dehydrogenase (ProDH) and pyrroline-5-carboxylate (P5C) dehydrogenase (P5CDH). In addition, ornithine δ-aminotransferase (δOAT) also participates in P5C formation through the conversion of ornithine and α-ketoglutarate into glutamate and P5C. Using mutants and biochemical approaches, ProDH1, P5CDH and δOAT were shown to be involved during dark-induced leaf senescence (DIS) in Arabidopsis thaliana. Striking accumulation of P5C and proline was observed in p5cdh mutant and to a lesser extent in prodh1prodh2 mutant, suggesting a putative proline-P5C cycle. Metabolomic analysis indicated that prodh1prodh2 and p5cdh have a similar metabolomic profile, but significantly different from wild-type and oat mutant, demonstrating the role of proline oxidation during DIS. ProDH1 was shown to be preferentially associated to the mitochondrial membrane fraction, while P5CDH and δOAT are more evenly distributed between matrix and membrane fractions. Homo- and hetero-oligomerizations of ProDH1, P5CDH, and δOAT were revealed using Bimolecular Fluorescence Complementation (BiFC) assay of infiltrated tobacco leaves. Interactions between P5C metabolism enzymes were further highlighted in DIS leaves using proteomics approaches coupled with mass spectrometry. Our work demonstrates that these three enzymes form P5C metabolic complex(es) involved in the oxidation of proline to fuel mitochondrial electron transfer chain to support the energy needs of senescent cells
Hsueh, Li-Ching. "Studies on proline hydroxylases". Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365805.
Texto completoKüllchen, Felix B. "Studies on proline 3-hydroxylase". Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269221.
Texto completoSchulz, Daniel [Verfasser]. "L-Proline and Glutamatergic Neurotransmission : Clarifying the Modulatory Role of Neuronal L-Proline Transporter / Daniel Schulz". Bonn : Universitäts- und Landesbibliothek Bonn, 2012. http://d-nb.info/1044971096/34.
Texto completoLawrence, Christopher C. "Studies on bacterial proline 4-hydroxylase". Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358610.
Texto completoHu, Chien-an Andy. "Osmoregulation and proline biosynthesis in plants /". The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487843688956923.
Texto completoTownsend, David E. Wilkinson Brian J. "Proline transport and biosynthesis in Staphylococcus aureus". Normal, Ill. Illinois State University, 1992. http://wwwlib.umi.com/cr/ilstu/fullcit?p9311291.
Texto completoTitle from title page screen, viewed February 6, 2006. Dissertation Committee: Brian J. Wilkinson (chair), Radheshyam Jayaswal, Herman E. Brockman, Robert L. Preston, Philip D. Morse. Includes bibliographical references (leaves 107-112) and abstract. Also available in print.
Le, Dinh Thien. "Métabolisme de la proline chez les mammifères". Paris 5, 1988. http://www.theses.fr/1988PA05P216.
Texto completoHabibi-Najafi, Mohammad B. (Mohammad Bagher). "Proline-specific peptidases from Lactobacillus casei subspecies". Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28455.
Texto completoStorage stability of x-prolyl dipeptidyl peptidase and proline iminopeptidase in crude extract, with and without stabilizers showed no significant loss in activity of these two enzymes at 4$ sp circ$C for 9 days without adding any stabilizers. The levels of x-prolyl dipeptidyl peptidase, proline iminopeptidase, and post proline endopeptidase activities of cells grown in whey did not vary markedly from cells grown in MRS broth. X-prolyl dipeptidyl peptidase and proline iminopeptidase were purified from crude cell-free extract of Lactobacillus casei ssp. casei LLG by Fast Protein Liquid Chromatography (FPLC) equipped with ion-exchange and gel-filtration columns. X-prolyl dipeptidyl peptidase was found to be a serine-dependent enzyme with molecular mass of 79 kDa. The pH and the temperature optima by the purified enzyme were 7.0 and 50$ sp circ$C, respectively. Proline iminopeptidase was sulfhydryl enzyme with molecular mass of 46 kDa. The maximum enzyme activity was observed at pH 7.5 and 40$ sp circ$C. This is the first report describing the purification and characterization of x-prolyl dipeptidyl peptidase and proline iminopeptidase from Lactobacillus casei to homogeneity.
The debittering of tryptic digests from $ beta$-casein by x-prolyl dipeptidyl peptidase was studied by reversed phase high performance liquid chromatography (RP-HPLC) and liquid chromatography/mass spectrometry. The results showed that two bitter peptides (f53-97 and f03-209) containing X-Pro-Y-Pro in their amino acid residues were completely hydrolyzed and many other peptides with high hydrophobicity were decreased in peak area. The addition of purified x-prolyl dipeptidyl peptidase on bitter enzyme-modified cheese (EMC) also showed that at least one bitter peptide with X-Pro-Y derived from $ alpha$-casein hydrolysis was removed.
Walters, Nicola Jane. "Arginine and proline catabolism in Schizosaccharomyces pombe". Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257192.
Texto completoRobinson, Kenneth J. "Bio-organic studies on proline 4-hydroxylase". Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320660.
Texto completoJones, Iwan Gwynedd. "Desymmetrization of meso-anhydrides by proline esters". Thesis, Bangor University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265515.
Texto completoDaly, D. J. "Post-proline cleaving enzymes in skeletal muscle". Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304040.
Texto completoD'Rozario, Robert S. G. "Conformational dynamics of proline-containing transmembrane helices". Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670181.
Texto completoPike, Claire Victoria Sarah. "The proline isomerase FKBP25 as a chromatin modifier". Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/252175.
Texto completoVerbruggen, Nathalie. "Proline accumulation after salt-stress in arabidopsis thaliana". Doctoral thesis, Universite Libre de Bruxelles, 1992. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212895.
Texto completoDikic, Inga. "Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5316-3/.
Texto completoNorris, Simon Richard. "Studies towards the synthesis of useful proline derivatives". Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315897.
Texto completoBess, Kirstin. "Transcriptional repression by the proline rich homeodomain protein". Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390994.
Texto completoOmar, Muhiadin. "Biotransformations of proline by 2-oxoglutarate-dependent hydroxylases". Thesis, University of York, 2017. http://etheses.whiterose.ac.uk/19532/.
Texto completoShibasaki, Takeshi. "SCREENING AND APPLIED STUDIES OF MICROBIAL PROLINE HYDROXYLASES". Kyoto University, 2001. http://hdl.handle.net/2433/150792.
Texto completoWhite, Tommi Anna. "Structural and functional studies of proline catabolic enzymes". Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4760.
Texto completoThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on March 24, 2009) Vita. Includes bibliographical references.
UEDA, Akihiro, Weiming SHI, Takiko SHIMADA, Hiroshi MIYAKE y Tetsuko TAKABE. "Altered expression of barley proline transporter causes different growth responses in Arabidopsis". Springer, 2007. http://hdl.handle.net/2237/8780.
Texto completoEriksen, Heidi Sofie. "The synthesis and use of polymer supported β amino sulfur containing catalysts". Thesis, University of Strathclyde, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248596.
Texto completoNguyen, Thi-Huong. "Synthèse de nouveaux catalyseurs chiraux à base de la L-proline. Applications en catalyse asymétrique". Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112382.
Texto completoFor many years, multifunctional chiral phosphines have proven to be powerful synthetic tools in asymmetric organocatalysis. These catalysts, containing Lewis basic and Brnsted acidic sites, have received considerable attention owing to their highly efficiency to create C-C bond by asymmetric organocatalysis. To our knowledge, the synthesis of organocatalysts type thiourea-phosphine derivatives (L) -proline have never been described in the literature. In this work, we wish to report the synthesis of new family of bifunctional chiral thiourea-phosphine organocatalyst derived from L-proline, a natural available product. We developed efficient methods to prepare three families of phosphine thiourea derived from L-proline. Thus, Seven new enantiopure compounds were synthesized in this study. They were used as catalyst asymmetric reaction catalyzed by phosphines: [3+2] cyclisation, Baylis-Hillman reaction, Friedel-Crafts reaction and nucleophilic substitution
Picard, François J. "Genetics of arginine and proline biosynthesis in Neisseria gonorrhoeae". Thesis, University of Ottawa (Canada), 1991. http://hdl.handle.net/10393/7669.
Texto completoDigennaro, Angela [Verfasser]. "Proline-Quaterthiophene hybrids: Synthesis and self-assembly / Angela Digennaro". Ulm : Universität Ulm, 2017. http://d-nb.info/112490249X/34.
Texto completoWood, Nicholas James. "The role of proline in osmoregulation by a streptomycete". Thesis, University of Warwick, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319812.
Texto completoMurray, Nicola Jane. "NMR studies of salivary proline-rich proteins and tannins". Thesis, University of Sheffield, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284595.
Texto completoSwingler, Tracey. "Transcriptional repression by the proline rich homeodomain protein (PRH)". Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419215.
Texto completoRoosens, Nancy. "Proline biosynthesis related to salt stress in higher plants". Doctoral thesis, Universite Libre de Bruxelles, 1999. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211926.
Texto completoObayashi, Yoko. "Novel physiological function of proline and mTOR regulator tuberin". Kyoto University, 2018. http://hdl.handle.net/2433/232154.
Texto completoAillard, Boris. "Small molecule mimics of trans-proline : synthesis and applications". Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/367097/.
Texto completoVoss, Emelyne. "Synthèse d’Analogues Bis-azotés de la Proline et Applications". Thesis, Vandoeuvre-les-Nancy, INPL, 2011. http://www.theses.fr/2011INPL059N/document.
Texto completoThe peptidic bond in a peptide or a protein is usually flat and in trans conformation for the majority of amino acids. The situation is a little bit different upstream the proline: the thermodynamic barrier which opposes the rotation of the amide bond is weaker and the tendency of the bond to remain flat is lesser. So, this AA-Pro bond can adopt a cis conformation, leading to the formation of a turn in the peptidic chain. This work describes the synthesis and the chemical reactivity of new bis-nitrogen analogous of proline in solution to facilitate the cis conformation of a AA-PΨPro bond. The conformational impact that these residues may generate in pseudopeptides is also exposed.Initially, a new access road to the orthogonally protected and enantiomerically pure δ-azaproline has been developed by exploiting previous work on the synthesis of α- hydrazinoesters and N-aminodipeptides. The study of the reactivity of this pseudoproline helped define the best conditions for forming pseudotripeptides of formula P1-AA1--δ-azaPro-AA3-P3. It also guided the work, in a second step, towards the synthesis of pseudopeptide incorporating a pyrazole acid motif. Finally, the structure of the prepared compounds was analyzed by NMR, IR and molecular modeling. Examination of the P1-AA1-δ-azaPro(Boc)-AA3-P3 revealed the formation of a pseudocycle C7 by a Hydrogen bond, favoring the trans conformation of the AA1-δ-azaPro bond, while the absence of Boc function seems to favor the cis conformation of this bond
Zhang, Min. "Crystallographic studies of the E. coli puta proline dehydrogenase domain /". free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1426119.
Texto completoLilley, Ian Andrew. "Synthetic studies using chiral stabilised azomethine ylids". Thesis, University of Oxford, 1995. https://ora.ox.ac.uk/objects/uuid:64d5745b-e6ef-4a77-8abe-b01f1c627e8f.
Texto completoTouchal, Samira. "Synthèse de nouveaux matériaux polymères hydrosolubles : application à la séparation de mélanges de solvants organiques de type alcool / éther par pervaporation". Vandoeuvre-les-Nancy, INPL, 2003. http://docnum.univ-lorraine.fr/public/INPL_T_2003_TOUCHAL_S.pdf.
Texto completoLeung, Ka Wing. "PRiMA, a membrane anchor of tetrameric acetylcholinesterase (AChE), directs the restricted localization of the enzyme in muscle and neuron /". View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202009%20LEUNG.
Texto completoMok, Ka Wai. "Proline-rich membrane anchor (PRiMA) of acetylcholinesterase (AChE) : characterization of its splicing variants and their expression profiles in different chicken tissues /". View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202009%20MOK.
Texto completoLuo, Bo. "Isomérisation de cycle d'azéphanes polyhydroxylés : accès à de nouvelles pipéridines et pyrrolidines polyhydroxylées". Paris 6, 2011. http://www.theses.fr/2011PA066748.
Texto completoDrzymala, Luke. "Phosphorylation of human salivary proline-rich proteins in cultured cells". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0001/MQ40692.pdf.
Texto completoSoufi, Abdenour. "Oligomerisation and phosphorylation of the proline-rich homeodomain protein (PRH)". Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432944.
Texto completoDebrauwer, Laurent. "Etude de l'interaction glucose-proline dans la réaction de Maillard". Aix-Marseille 3, 1989. http://www.theses.fr/1989AIX30038.
Texto completoHe, Jing. "Design and Study of Novel Antimicrobial Peptides with Proline Substitution". Ohio University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1257779581.
Texto completoZhang, Chun-sheng. "Regulation of proline biosynthesis in plants subjected to osmotic stress /". The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487948807588165.
Texto completoPruitt, Corunda T. "Effects of compatible solutes on cold tolerance of propionibacterium freudenreichii and the significance of propionibacterium cold tolerance in Swiss cheese manufacturing". Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1123184280.
Texto completoTitle from first page of PDF file. Document formatted into pages; contains xiv, 107 p.; also includes graphics. Includes bibliographical references (p. 90-97). Available online via OhioLINK's ETD Center
Flores, Ortega Alejandra. "Conformational properties of constrained proline analogues and their application in nanobiology". Doctoral thesis, Universitat Politècnica de Catalunya, 2009. http://hdl.handle.net/10803/6477.
Texto completoWe have used different computer simulation techniques to investigate the impact of different chemical modifications on the conformational preferences of proline and to examine the application of conformationally constrained proline analogues in Nanobiology.
Specifically, the first part shows the conformational study of proline derivatives that were obtained by introducing one or more double bonds in the pyrrolidine ring, by replacing the α-hydrogen atom by an alkyl group or by incorporating a polar substituent at the β- or γ-position of the pyrrolidine ring. These conformational investigations were performed using Quantum Mechanical calculations at the DFT (Density Functional Theory) levels. Furthermore, the influence of the solvent on the preferences of the different proline derivatives was examined using the Polarizable Continuum Model (PCM).
The second part of the work consists on the design of a constrained proline derive able to protect a tumor-homing peptide from the attack of proteases but retaining, or even enhancing, its intrinsic biological activity. For this purpose, the bioactive conformation of the tumor-homing peptide was determined and characterized using a computational strategy based on the combination of Simulated Annealing combined with Molecular Dynamics. After this, the designed proline was derivative was introduced in the biological peptide using a targeted replacement strategy. The efficiency of the synthetic derivative was examined in silico using classical force-field simulations.
La presente Tesis consta de dos partes:
Se han empleado distintas técnicas de simulación computacional para investigar el efecto de diferentes modificaciones químicas en las preferencias conformacionales de las prolina, así como para examinar la aplicación de análogos de prolina conformacionalmente restringidos en Nanobiología.
Concretamente, la primera parte presenta el estudio conformacional de los derivados de la prolina que se obtienen al introducir uno o más enlaces dobles en el anillo de pirrolidona, al substituir el hidrógeno α por un grupo alquilo o al incorporar un grupo polar en la posición β ó γ del anillo de pirrolidona. Estos estudios conformacionales se desarrollaron mediante métodos mecano-cuánticos basados en la Teoría del Funcional de la Densidad (DFT). Además, el efecto del disolvente en las preferencias de los diferentes derivados de prolina se investigo empleado el método PCM (Polarizable Continuum Model).
La segunda parte del trabajo consistió en el diseño de un análogo de prolina capaz de proteger un péptido que actúa como marcador tumoral del ataque de las proteasas a la vez que retiene, o incluso mejora, su actividad biológica. Para conseguir esto, inicialmente se determinó y caracterizó la conformación bioactiva del péptido empleando una estrategia computacional basada en la combinación de templado simulado y Dinámica Molecular. A continuación el derivado de prolina diseñado se incorporó en una posición específica del péptido y la eficiencia del sistema resultante fue estudiada in silico usando simulaciones basadas en potenciales clásicos.
Chan, Maggie Tin Lai. "Proteolytic processing of recombinant human salivary proline-rich protein precursors (PRPs)". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0025/MQ50333.pdf.
Texto completoKofler, Michael. "GYF domains a class of proline rich ligand binding adaptor domains /". kostenfrei, 2007. http://www.diss.fu-berlin.de/2007/261/index.html.
Texto completoTempel, Wolfram. "Synthesis and in vitro activity of proline-based ketomethylene dipeptide isoteres". Thesis, University of Salford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299103.
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