Tesis sobre el tema "Cardiovascular fluid dynamic"
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GALLO, CATERINA. "A multiscale modelling of the cardiovascular fluid dynamics for clinical and space applications". Doctoral thesis, Politecnico di Torino, 2021. http://hdl.handle.net/11583/2872354.
Texto completoSoudah, Prieto Eduardo. "Computational fluid dynamics indicators to improve cardiovascular pathologies". Doctoral thesis, Universitat Politècnica de Catalunya, 2016. http://hdl.handle.net/10803/392613.
Texto completoEn els últims anys, l'estudi de l'hemodinàmica computacional en regions vasculars anatòmicament complexes ha generat un gran interès entre els clínics. El progrés obtingut en la dinàmica de fluids computacional, en el processament d'imatges i en la computació d'alt rendiment ha permès identificar regions vasculars on poden aparèixer malalties cardiovasculars, així com predir-ne l'evolució. Actualment, la medicina utilitza un paradigma anomenat diagnòstic. En aquesta tesi s'intenta introduir en la medicina el paradigma predictiu utilitzat des de fa molts anys en l'enginyeria. Per tant, aquesta tesi té com a objectiu desenvolupar models predictius basats en indicadors de diagnòstic de patologies cardiovasculars. Tractem de predir l'evolució de l'aneurisma d'aorta abdominal, la coartació aòrtica i la malaltia coronària de forma personalitzada per a cada pacient. Per entendre com la patologia cardiovascular evolucionarà i quan suposarà un risc per a la salut, cal desenvolupar noves tecnologies mitjançant la combinació de les imatges mèdiques i la ciència computacional. Proposem uns indicadors que poden millorar el diagnòstic i predir l'evolució de la malaltia de manera més eficient que els mètodes utilitzats fins ara. En particular, es proposa una nova metodologia per al càlcul dels indicadors de diagnòstic basada en l'hemodinàmica computacional i les imatges mèdiques. Hem treballat amb dades de pacients anònims per crear una tecnologia predictiva real que ens permetrà seguir avançant en la medicina personalitzada i generar sistemes de salut més sostenibles. Però el nostre objectiu final és aconseguir un impacte en l¿àmbit clínic. Diversos grups han tractat de crear models predictius per a les patologies cardiovasculars, però encara no han començat a utilitzar-les en la pràctica clínica. El nostre objectiu és anar més enllà i obtenir variables predictives que es puguin utilitzar de forma pràctica en el camp clínic. Es pot preveure que en el futur tots els metges disposaran de bases de dades molt precises de tota la nostra anatomia i fisiologia. Aquestes dades es poden utilitzar en els models predictius per millorar el diagnòstic o per millorar teràpies o tractaments personalitzats.
Toninato, Riccardo. "Development of a Laboratory for Cardiovascular Fluid Dynamics Studies". Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424325.
Texto completoNella presente tesi di Dottorato è descritta la realizzazione e lo sviluppo di un nuovo laboratorio sperimentale per studi di fluidodinamica cardiovascolare. Il laboratorio, denominato Healing Research Laboratory (HeR Lab), a tre anni dalla sua creazione, è una realtà di Dipartimento consolidata; presente nel dip. ICEA dell’Università degli Studi di Padova. Nel proseguo dell’elaborato vengono indagati gli aspetti che hanno partecipato allo sviluppo del laboratorio, ed i principali campi di ricerca che sono stati toccati lungo il percorso di dottorato. La tesi è strutturata in quattro parti principali: la prima fornisce una panoramica del distretto aortico, in relazione all’inserimento di device protesici, sia dal punto di vista fisiologico che ingegneristico. La seconda parte è incentrata nella descrizione approfondita della ricerca sperimentale. Si focalizza nella progettazione, realizzazione e messa punto di un circuito meccanico-idraulico (chiamato pulse duplicator), per lo studio della fluido dinamica nella circolazione sistemica, a seguito dell’impianto di dispositivi protesici. Parte innovativa è costituta dalla presenza di un prototipo siliconico compliante di radice aortica ottenuta da CT-scan di paziente, per lo studio delle caratteristiche meccaniche del vaso e dei campi fluidodinamici locali. La terza sezione è costituita da progetti sperimentali sviluppati in strutture esterne all’HeR Lab. Il primo presso la Cardiochirurgia, dipartimento di Scienze Cardiache, Toraciche e Vascolari della Università degli Studi di Padova, allo scopo di investigare le performance emodinamiche di un cuore artificiale totale (CardioWest TAH-t); la seconda come membro dell’UCL Cardiovascular Engineering Laboratory (University College London), con l’obiettivo di indagare le performance di valvole aortiche biologiche per via sperimentale. La quarta sezione descrive uno studio numerico basato sul design di un modello meccanico 2D del globulo rosso, e sul calcolo di deformazioni e danni subiti dalla membrana, dovuti agli sforzi tangenziali indotti dal flusso effluente da valvole aortiche meccaniche. Lo sviluppo del laboratorio e del nuovo gruppo di ricerca cardiovascolare ha permesso di incamerare ottime competenze nell’ambito della ricerca e progettazione, dando la possibilità di toccare diversi aspetti dello sviluppo, dalla ricerca fondi alla realizzazione fisica di prototipi o banchi sperimentali.
Ebbers, Tino. "Cardiovascular fluid dynamics : methods for flow and pressure field analysis from magnetic resonance imaging /". Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/tek690s.pdf.
Texto completoMumpower, Edward Lee. "Effect of disc angulation on the fluid dynamics of a tilting disc mitral valve prosthesis". Thesis, Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/32827.
Texto completoHealy, Timothy M. "Multi-block and overset-block domain decomposition techniques for cardiovascular flow simulation". Diss., Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/15622.
Texto completoFan, Yi y 樊怡. "The applications of computational fluid dynamics to the cardiovascularsystem and the respiratory system". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47753195.
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Mechanical Engineering
Master
Master of Philosophy
Khare, Aditi. "Estimation and control of the pump pressure rise and flow from intrinsic parameters for a magnetically-levitated axial blood pump /". Online version of thesis, 2008. http://hdl.handle.net/1850/7988.
Texto completoRandles, Amanda Elizabeth. "Modeling cardiovascular hemodynamics using the lattice Boltzmann method on massively parallel supercomputers". Thesis, Harvard University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3567037.
Texto completoAccurate and reliable modeling of cardiovascular hemodynamics has the potential to improve understanding of the localization and progression of heart diseases, which are currently the most common cause of death in Western countries. However, building a detailed, realistic model of human blood flow is a formidable mathematical and computational challenge. The simulation must combine the motion of the fluid, the intricate geometry of the blood vessels, continual changes in flow and pressure driven by the heartbeat, and the behavior of suspended bodies such as red blood cells. Such simulations can provide insight into factors like endothelial shear stress that act as triggers for the complex biomechanical events that can lead to atherosclerotic pathologies. Currently, it is not possible to measure endothelial shear stress in vivo, making these simulations a crucial component to understanding and potentially predicting the progression of cardiovascular disease. In this thesis, an approach for efficiently modeling the fluid movement coupled to the cell dynamics in real-patient geometries while accounting for the additional force from the expansion and contraction of the heart will be presented and examined.
First, a novel method to couple a mesoscopic lattice Boltzmann fluid model to the microscopic molecular dynamics model of cell movement is elucidated. A treatment of red blood cells as extended structures, a method to handle highly irregular geometries through topology driven graph partitioning, and an efficient molecular dynamics load balancing scheme are introduced. These result in a large-scale simulation of the cardiovascular system, with a realistic description of the complex human arterial geometry, from centimeters down to the spatial resolution of red-blood cells. The computational methods developed to enable scaling of the application to 294,912 processors are discussed, thus empowering the simulation of a full heartbeat.
Second, further extensions to enable the modeling of fluids in vessels with smaller diameters and a method for introducing the deformational forces exerted on the arterial flows from the movement of the heart by borrowing concepts from cosmodynamics are presented. These additional forces have a great impact on the endothelial shear stress. Third, the fluid model is extended to not only recover Navier-Stokes hydrodynamics, but also a wider range of Knudsen numbers, which is especially important in micro- and nano-scale flows. The tradeoffs of many optimizations methods such as the use of deep halo level ghost cells that, alongside hybrid programming models, reduce the impact of such higher-order models and enable efficient modeling of extreme regimes of computational fluid dynamics are discussed. Fourth, the extension of these models to other research questions like clogging in microfluidic devices and determining the severity of co-arctation of the aorta is presented. Through this work, a validation of these methods by taking real patient data and the measured pressure value before the narrowing of the aorta and predicting the pressure drop across the co-arctation is shown. Comparison with the measured pressure drop in vivo highlights the accuracy and potential impact of such patient specific simulations.
Finally, a method to enable the simulation of longer trajectories in time by discretizing both spatially and temporally is presented. In this method, a serial coarse iterator is used to initialize data at discrete time steps for a fine model that runs in parallel. This coarse solver is based on a larger time step and typically a coarser discretization in space. Iterative refinement enables the compute-intensive fine iterator to be modeled with temporal parallelization. The algorithm consists of a series of prediction-corrector iterations completing when the results have converged within a certain tolerance. Combined, these developments allow large fluid models to be simulated for longer time durations than previously possible.
Ebrahimi, Pegah. "Patient-specific design of the right ventricle to pulmonary artery conduit via computational analysis". Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20381.
Texto completoKitajima, Hiroumi D. "In Vitro Fluid Dynamics of Stereolithographic Single Ventricle Congenital Heart Defects From In Vivo Magnetic Resonance Imaging". Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/25074.
Texto completoWang, Jiaqiu. "Image-based patient-specific computational biomechanical analysis of the interaction between blood flow and atherosclerosis". Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/202017/1/Jiaqiu_Wang_Thesis.pdf.
Texto completoD, Souza Gavin A. "Influence of Serial Coronary Stenoses on Diagnostic Parameters: An In-vitro Study with Numerical Validation". University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397234083.
Texto completoCollin, Sophie. "Preoperative planning and simulation for artificial heart implantation surgery". Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1S025/document.
Texto completoMechanical Circulatory Support (MCS) therapy is increasingly considered for patients with advanced heart failure unresponsive to optimal medical treatments. In this context, we: 1) presented an overview of clinical issues raised by MCS implantation, 2) designed a novel computer-assisted approach for planning the implantation, 3) implemented a CFD model to understand the ventricle hemodynamics induced by the inflow cannula pose. With the aim of decreasing complications and morbidity, quantitative criteria for optimizing ventricle unloading could be determined through CFD, and the planning approach may provide valuable information for choosing the device and adapting the clinical strategy
Rahman, Roussel. "Analysis and Sensitivity Study of Zero-Dimensional Modeling of Human Blood Circulation Network". Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1494769445938849.
Texto completoYun, Brian Min. "Simulations of pulsatile flow through bileaflet mechanical heart valves using a suspension flow model: to assess blood damage". Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/53378.
Texto completoLevilly, Sébastien. "Quantification de biomarqueurs hémodynamiques en imagerie cardiovasculaire par résonance magnétique de flux 4D". Thesis, Ecole centrale de Nantes, 2020. http://www.theses.fr/2020ECDN0007.
Texto completoIn cardiovascular imaging, a biomarker is quantitative information correlated with an existing or growing cardiovascular pathology. Biomarkers are generally obtained by anatomy and blood flow imaging. Recently, the 4D Flow MRI sequence opened new opportunities in measuring the blood flow within a 3D volume along the cardiac cycle. However, this sequence is a compromise between signalto-noise ratio, resolution and acquisition time. Allocated time being limited, velocity measurements are noisy and low resolution. In that context, biomarkers' quantification is challenging. This thesis's purpose is to enhance biomarkers' quantification and particularly for the wall shear stress (WSS). Two strategies have been investigated to reach that objective. A first solution allowing the spatiotemporal filtering of the velocity field has been proposed. It revealed the importance of the wall for the velocity field modelization. A second approach, being the major contribution of this work, focused on the design of a WSS quantification algorithm. This algorithm, named PaLMA, is based on the local modelization of the wall to build a velocity model near a point of interest. The WSS is computed from the velocity model. This algorithm embeds an a posteriori regularization step to improve the WSS quantification. Besides, a blurring model of 4D Flow MRI is used for the first time in the WSS quantification context. Finally, this algorithm has been validated over synthetic datasets, with carotids' complex flows, concerning the signal-to-noise ratio, the resolution, and the segmentation. The performances of PaLMA are superior to a reference solution in that domain, within a clinical routine context
Ceballos, Andres. "A multiscale model of the neonatal circulatory system following Hybrid Norwood palliation". Master's thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4866.
Texto completoID: 030423155; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Thesis (M.S.)--University of Central Florida, 2011.; Includes bibliographical references (p. 59-61).
M.S.
Masters
Mechanical, Materials, and Aerospace Engineering
Engineering and Computer Science
Moghaddaszade, Kermani Ahmad. "Fluid-structure interaction studies on the cardiovascular hemodynamics of a mitral valve". Thesis, 2011. http://hdl.handle.net/1828/3767.
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Lin, Ben Albert. "Ultrasound Speckle Image Velocimetry: Studies on System Performance and Application to Cardiovascular Fluid Dynamics". Thesis, 2018. https://thesis.library.caltech.edu/10380/1/Lin-Caltech-FINAL-APPROVED.pdf.
Texto completo"Improved Techniques for Cardiovascular Flow Experiments". Doctoral diss., 2015. http://hdl.handle.net/2286/R.I.36516.
Texto completoDissertation/Thesis
Doctoral Dissertation Bioengineering 2015
Lightstone, Noam S. "Design of a Bioreactor to Mimic Hemodynamic Shear Stresses on Endothelial Cells in Microfluidic Systems". Thesis, 2014. http://hdl.handle.net/1807/65572.
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