Bibliografías temáticas / CAPNS1

Literatura académica sobre el tema "CAPNS1"

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Publicado: 20 de abril de 2024

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Artículos de revistas sobre el tema "CAPNS1"

1

Kumar, Vijay, Chris Hall, Peter Greer y Andrew Craig. "Calpain proteases are required for effective clearance of enterobacteria within the peritoneum of mice to prevent systemic infection (112.5)". Journal of Immunology 188, n.º 1_Supplement (1 de mayo de 2012): 112.5. http://dx.doi.org/10.4049/jimmunol.188.supp.112.5.

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Abstract The ubiquitously expressed calpain 1 and 2 isoforms are heterodimers consisting of a catalytic subunit (capn1 or capn2), and a common regulatory capns1-encoded subunit, which is required for protease stability and activity. Although calpains regulate neutrophil and macrophage activation, their roles in immunity remain poorly defined. Here, we use fes-driven Cre recombinase (fes-Cre) to delete capns1 in mice, thus eliminating calpain 1/2 activity in Cre-expressing cells. We detect near complete capns1 deletion in hematopoietic cells, consistent with the tissue-specific expression pattern of fes. Next, we compared the response of control and capns1 targeted mice in the feces-in-peritoneum (FIP) model of sepsis (i.p. injection of enterobacteria). At 2-6 hours post infection, mice were sacrificed and bacterial load, neutrophil recruitment, and cytokine levels in peritoneal lavage fluid (PLF) and peripheral blood were compared between genotypes. We observed comparable levels of neutrophil infiltration and cytokine production in PLF from control and capns1 targeted FIP-treated mice. However, bacterial killing was highly reduced (>10-fold) in capns1 targeted compared to control mice; and this correlated with increased enterobacterial escape to the peripheral blood. These observations suggest that calpains are not required for inflammatory cytokine production or neutrophil recruitment, but they are required for bacterial clearance, and may protection against development of sepsis.
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Piper, Ann-Katrin, Reece A. Sophocleous, Samuel E. Ross, Frances J. Evesson, Omar Saleh, Adam Bournazos, Joe Yasa et al. "Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy". American Journal of Physiology-Cell Physiology 318, n.º 6 (1 de junio de 2020): C1226—C1237. http://dx.doi.org/10.1152/ajpcell.00408.2019.

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The ubiquitous calpains, calpain-1 and -2, play important roles in Ca2+-dependent membrane repair. Mechanically active tissues like skeletal muscle are particularly reliant on mechanisms to repair and remodel membrane injury, such as those caused by eccentric damage. We demonstrate that calpain-1 and -2 are master effectors of Ca2+-dependent repair of mechanical plasma membrane scrape injuries, although they are dispensable for repair/removal of small wounds caused by pore-forming agents. Using CRISPR gene-edited human embryonic kidney 293 (HEK293) cell lines, we established that loss of both calpains-1 and -2 ( CAPNS1−/−) virtually ablates Ca2+-dependent repair of mechanical scrape injuries but does not affect injury or recovery from perforation by streptolysin-O or saponin. In contrast, cells with targeted knockout of either calpain-1 ( CAPN1−/−) or -2 ( CAPN2−/−) show near-normal repair of mechanical injuries, inferring that both calpain-1 and calpain-2 are equally capable of conducting the cascade of proteolytic cleavage events to reseal a membrane injury, including that of the known membrane repair agent dysferlin. A severe muscular dystrophy in a murine model with skeletal muscle knockout of Capns1 highlights vital roles for calpain-1 and/or -2 for health and viability of skeletal muscles not compensated for by calpain-3 ( CAPN3). We propose that the dystrophic phenotype relates to loss of maintenance of plasma membrane/cytoskeletal networks by calpains-1 and -2 in response to directed and dysfunctional Ca2+-signaling, pathways hyperstimulated in the context of membrane injury. With CAPN1 variants associated with spastic paraplegia, a severe dystrophy observed with muscle-specific loss of calpain-1 and -2 activity identifies CAPN2 and CAPNS1 as plausible candidate neuromuscular disease genes.
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Mellgren, Ronald L. y Xinhua Huang. "Fetuin A Stabilizes m-Calpain and Facilitates Plasma Membrane Repair". Journal of Biological Chemistry 282, n.º 49 (17 de octubre de 2007): 35868–77. http://dx.doi.org/10.1074/jbc.m706929200.

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Yeast two-hybrid experiments identified α2-Heremans-Schmid glycoprotein (human fetuin A) as a binding partner for calpain domain III (DIII). The tandem DIIIs of calpain-10 interacted under the most selective culture conditions, but DIIIs of m-calpain, calpain-3, and calpain-5 also interacted under less stringent selection. DIIIs of μ-calpain, calpain-6, and the tandem DIII-like domains of the Dictyostelium Cpl protein did not interact with α2-Heremans-Schmid glycoprotein in the yeast two-hybrid system. Bovine fetuin A stabilized proteolytic activity of purified m-calpain incubated in the presence of mm calcium chloride and prevented calcium-dependent m-calpain aggregation. Consistent with the yeast two-hybrid studies, fetuin A neither stabilized μ-calpain nor prevented its aggregation. Confocal immunofluorescence microscopy of scratch-damaged L6 myotubes demonstrated accumulation of m-calpain at the wound site in association with the membrane repair protein, dysferlin. m-Calpain also co-localized with fluorescein-labeled fetuin A at the wound site. The effect of fetuin A on calpain-mediated plasma membrane resealing was investigated using fibroblasts from Capns1-/- and Capns1+/+ mouse embryos. Capns1 encodes the small noncatalytic subunit that is required for the proteolytic function of m- and μ-calpains. Thus, Capns1-/- fibroblasts do not express these calpains in active form. Fetuin A increased resealing of scrape-damaged wild-type fibroblasts but not Capns1-/- fibroblasts. These studies identify fetuin A as a potential extracellular regulator of m-calpain at nascent sites of plasma membrane wounding.
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4

Tyagi, Tarun, Shadab Ahmad, Neha Gupta, Anita Sahu, Yasmin Ahmad, Velu Nair, Tathagat Chatterjee et al. "Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype". Blood 123, n.º 8 (20 de febrero de 2014): 1250–60. http://dx.doi.org/10.1182/blood-2013-05-501924.

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Key Points Hypoxia induces altered platelet proteome/reactivity, which correlates with a prothrombotic phenotype. CAPNS1-dependent calpain activity in platelet activation cascade is associated with hypoxia-induced thrombogenesis.
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5

Demarchi, Francesca, Cosetta Bertoli, Tamara Copetti, Isei Tanida, Claudio Brancolini, Eeva-Liisa Eskelinen y Claudio Schneider. "Calpain is required for macroautophagy in mammalian cells". Journal of Cell Biology 175, n.º 4 (13 de noviembre de 2006): 595–605. http://dx.doi.org/10.1083/jcb.200601024.

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Ubiquitously expressed micro- and millicalpain, which both require the calpain small 1 (CAPNS1) regulatory subunit for function, play important roles in numerous biological and pathological phenomena. We have previously shown that the product of GAS2, a gene specifically induced at growth arrest, is an inhibitor of millicalpain and that its overexpression sensitizes cells to apoptosis in a p53-dependent manner (Benetti, R., G. Del Sal, M. Monte, G. Paroni, C. Brancolini, and C. Schneider. 2001. EMBO J. 20:2702–2714). More recently, we have shown that calpain is also involved in nuclear factor κB activation and its relative prosurvival function in response to ceramide, in which calpain deficiency strengthens the proapoptotic effect of ceramide (Demarchi, F., C. Bertoli, P.A. Greer, and C. Schneider. 2005. Cell Death Differ. 12:512–522). Here, we further explore the involvement of calpain in the apoptotic switch and find that in calpain-deficient cells, autophagy is impaired with a resulting dramatic increase in apoptotic cell death. Immunostaining of the endogenous autophagosome marker LC3 and electron microscopy experiments demonstrate that autophagy is impaired in CAPNS1-deficient cells. Accordingly, the enhancement of lysosomal activity and long-lived protein degradation, which normally occur upon starvation, is also reduced. In CAPNS1-depleted cells, ectopic LC3 accumulates in early endosome-like vesicles that may represent a salvage pathway for protein degradation when autophagy is defective.
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6

Liang, Liwen, Huili Li, Ting Cao, Lina Qu, Lulu Zhang, Guo-Chang Fan, Peter A. Greer, Jianmin Li, Douglas L. Jones y Tianqing Peng. "Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways". Journal of Biological Chemistry 295, n.º 49 (28 de septiembre de 2020): 16840–51. http://dx.doi.org/10.1074/jbc.ra119.011890.

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The human cardiovascular system has adapted to function optimally in Earth's 1G gravity, and microgravity conditions cause myocardial abnormalities, including atrophy and dysfunction. However, the underlying mechanisms linking microgravity and cardiac anomalies are incompletely understood. In this study, we investigated whether and how calpain activation promotes myocardial abnormalities under simulated microgravity conditions. Simulated microgravity was induced by tail suspension in mice with cardiomyocyte-specific deletion of Capns1, which disrupts activity and stability of calpain-1 and calpain-2, and their WT littermates. Tail suspension time-dependently reduced cardiomyocyte size, heart weight, and myocardial function in WT mice, and these changes were accompanied by calpain activation, NADPH oxidase activation, and oxidative stress in heart tissues. The effects of tail suspension were attenuated by deletion of Capns1. Notably, the protective effects of Capns1 deletion were associated with the prevention of phosphorylation of Ser-345 on p47phox and attenuation of ERK1/2 and p38 activation in hearts of tail-suspended mice. Using a rotary cell culture system, we simulated microgravity in cultured neonatal mouse cardiomyocytes and observed decreased total protein/DNA ratio and induced calpain activation, phosphorylation of Ser-345 on p47phox, and activation of ERK1/2 and p38, all of which were prevented by calpain inhibitor-III. Furthermore, inhibition of ERK1/2 or p38 attenuated phosphorylation of Ser-345 on p47phox in cardiomyocytes under simulated microgravity. This study demonstrates for the first time that calpain promotes NADPH oxidase activation and myocardial abnormalities under microgravity by facilitating p47phox phosphorylation via ERK1/2 and p38 pathways. Thus, calpain inhibition may be an effective therapeutic approach to reduce microgravity-induced myocardial abnormalities.
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7

Cataldo, F., L. Y. Peche, E. Klaric, C. Brancolini, M. P. Myers, F. Demarchi y C. Schneider. "CAPNS1 Regulates USP1 Stability and Maintenance of Genome Integrity". Molecular and Cellular Biology 33, n.º 12 (15 de abril de 2013): 2485–96. http://dx.doi.org/10.1128/mcb.01406-12.

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Pisanu, Merkouri Papadima, Melis, Congiu, Loizedda, Orrù, Calza et al. "Whole Genome Expression Analyses of miRNAs and mRNAs Suggest the Involvement of miR-320a and miR-155-3p and their Targeted Genes in Lithium Response in Bipolar Disorder". International Journal of Molecular Sciences 20, n.º 23 (30 de noviembre de 2019): 6040. http://dx.doi.org/10.3390/ijms20236040.

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Lithium is the mainstay in the maintenance of bipolar disorder (BD) and the most efficacious pharmacological treatment in suicide prevention. Nevertheless, its use is hampered by a high interindividual variability and important side effects. Genetic and epigenetic factors have been suggested to modulate lithium response, but findings so far have not allowed identifying molecular targets with predictive value. In this study we used next generation sequencing to measure genome-wide miRNA expression in lymphoblastoid cell lines from BD patients excellent responders (ER, n = 12) and non-responders (NR, n = 12) to lithium. These data were integrated with microarray genome-wide expression data to identify pairs of miRNA/mRNA inversely and significantly correlated. Significant pairs were prioritized based on strength of association and in-silico miRNA target prediction analyses to select candidates for validation with qRT-PCR. Thirty-one miRNAs were differentially expressed in ER vs. NR and inversely correlated with 418 genes differentially expressed between the two groups. A total of 331 of these correlations were also predicted by in-silico algorithms. miR-320a and miR-155-3p, as well as three of their targeted genes (CAPNS1 (Calpain Small Subunit 1) and RGS16 (Regulator of G Protein Signaling 16) for miR-320, SP4 (Sp4 Transcription Factor) for miR-155-3p) were validated. These miRNAs and mRNAs were previously implicated in psychiatric disorders (miR-320a and SP4), key processes of the central nervous system (CAPNS1, RGS16, SP4) or pathways involved in mental illnesses (miR-155-3p). Using an integrated approach, we identified miRNAs and their targeted genes potentially involved in lithium response in BD.
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Rodríguez-Fernández, Lucía, Iván Ferrer-Vicens, Concha García, Sara S. Oltra, Rosa Zaragozá, Juan R. Viña y Elena R. García-Trevijano. "Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer". Biochemical Journal 473, n.º 18 (12 de septiembre de 2016): 2893–909. http://dx.doi.org/10.1042/bcj20160198.

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Cleavage of adhesion proteins is the first step for physiological clearance of undesired cells during postlactational regression of the mammary gland, but also for cell migration in pathological states such as breast cancer. The intracellular Ca2+-dependent proteases, calpains (CAPNs), are known to cleave adhesion proteins. The isoform-specific function of CAPN1 and CAPN2 was explored and compared in two models of cell adhesion disruption: mice mammary gland during weaning-induced involution and breast cancer cell lines according to tumor subtype classification. In both models, E-cadherin, β-catenin, p-120, and talin-1 were cleaved as assessed by western blot analysis. Both CAPNs were able to cleave adhesion proteins from lactating mammary gland in vitro. Nevertheless, CAPN2 was the only isoform found to co-localize with E-cadherin in cell junctions at the peak of lactation. CAPN2/E-cadherin in vivo interaction, analyzed by proximity ligation assay, was dramatically increased during involution. Calpain inhibitor administration prevented the cytosolic accumulation of truncated E-cadherin cleaved by CAPN2. Conversely, in breast cancer cells, CAPN2 was restricted to the nuclear compartment. The isoform-specific expression of CAPNs and CAPN activity was dependent on the breast cancer subtype. However, CAPN1 and CAPN2 knockdown cells showed that cleavage of adhesion proteins and cell migration was mediated by CAPN1, independently of the breast cancer cell line used. Data presented here suggest that the subcellular distribution of CAPN1 and CAPN2 is a major issue in target-substrate recognition; therefore, it determines the isoform-specific role of CAPNs during disruption of cell adhesion in either a physiological or a pathological context.
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Santos, Sara Costa, Lucas De Sousa Pontes, Maria Elisabete Amaral De Moraes y Caroline De Fátima Aquino Moreira-Nunes. "Identificação de alterações genéticas relacionadas à síndrome do X frágil e ao transtorno de espectro do autismo por meio de ferramentas de bioinformática". Revista de Ciências Médicas e Biológicas 19, n.º 2 (24 de septiembre de 2020): 292. http://dx.doi.org/10.9771/cmbio.v19i2.34910.

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<p><strong>Introdução</strong>: a Síndrome do X Frágil (FXS) é a forma mais prevalente de deficiência intelectual herdável, e é a principal causa monogênica<br />para o desenvolvimento de Transtorno de Espectro do Autismo (TEA). <strong>Objetivo</strong>: o objetivo do presente estudo é identificar RNAm<br />associados à possíveis vias neurocomportamentais na SFX como no TEA, através de ferramentas de bioinformática. <strong>Metodologia</strong>:<br />para identificação de possíveis vias alteradas entre a SFX e pacientes com TEA, utilizamos os bancos de dados GSE65106 e GSE21348<br />para anotação, visualização e descoberta integrada (DAVID 6.8). O valor de p &lt;0,05 e fold change maior que 2 vezes (FC &gt; 2) definidos<br />como os limiares para a identificação de genes diferencialmente expressos (DE-RNAm). <strong>Resultados</strong>: foi possível identificar cerca<br />de 32 DE-RNAm com funções em vias de spliceossomo, apoptose, transcrição, e em vias neurológicas comportamentais expressos<br />exclusivamente na SFX. Os genes CAPNS1, HNRNPK, HNRPM, foram identificados como hipoexpressos em indivíduos com síndrome<br />do X Frágil. Estes genes tem importante função moduladora nas respostas do potencial de longo prazo (LTP), plasticidade neural, e em<br />transportadores de serotonina (SERT) alterando respostas que englobam humor, cognição e comportamentos, além de interferirem<br />no receptor de dopamina (D2R) alterando as funções motoras e circuitos de recompensa. <strong>Conclusão</strong>: os genes CAPNS1, HNRNPK,<br />HNRNPM foram identificados como marcadores genéticos neurocomportamentais importantes para a síndrome do X-frágil com<br />expressão diminuída na doença, indicando uma possível modulação desses genes em aspectos fenotípicos marcantes da doença.</p>
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Tesis sobre el tema "CAPNS1"

1

Pamonsinlapatham, Perayot. "Etudes de l'interaction RasGAP/CAPNS1 et développement d'inhibiteurs du domaine SH3 de RasGAP". Paris 5, 2008. http://www.theses.fr/2008PA05P627.

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Indépendamment de son activité GEF (guanine exchange factor) désactivant Ras sous forme GDP, RasGAP agit comme un effecteur de Ras majeur dans les cellules tumorales impliquant de nouvelles voies de signalisation. Une approche innovante, pour valider l’inhibition d’interactions moléculaires de la protéine cible RasGAP a été la sélection d’aptamères peptidiques, que nous avons développés contre son domaine SH3 comme cible. Nous avons utilisé une approche combinatoire d’aptamère peptidique pour sélectionner une collection de ligands peptidiques spécifiques du domaine SH3 de RasGAP. Nous avons cartographié les sites de liaison de l’aptamère peptidique en présence d’un ensemble de mutation SH3-RasGAP en système de levure double hybride (AptaPrint). Nous avons étudié l’effet biologique d’un aptamère RG 27 qui cible une poche délimitée par les résidus D295/7, L313 et W317. Cet aptamère a un effet anti-prolifératif et anti-apoptotique qui n’est pas dépendant des caspases sur les cellules tumorales. Il inhibe l’interaction RasGAP et Aurora B. Dans la deuxième partie, nous avons décrit une nouvelle cible du domaine SH3 de RasGAP et étudié son interaction avec la petite sous unité commune des calpaïnes ubiquitaires Capns1. Cette petite sous-unité est un partenaire du domaine SH3 de RasGAP. L’interaction entre RasGAP et Capns1 est mise en évidence par coimmunoprécipitation et RasGAP pull-down et par microscopie confocale. Nous avons précisément étudié la migration de cellules PC3 (Raswt) et PC3-RasV12, qui expriment de façon stable la mutation de Ras oncogénique et la plus fréquemment retrouvée dans les cancers humains. Le complexe SH3-RasGAP/Capns1 est retrouvé augmenté d’un facteur 2 dans les protrusions des cellules C3-RasV12 par rapport celles des cellules PC3. En perturbant ce complexe par RNA interférence RasGAP, la migration cellulaire et l’apoptose des cellules exprimant la mutation RasV12 sont toutes deux perturbées, ce qui indique que RasGAP agit comme effecteur de Ras
Regardless of its activity as guanine exchange factor (GEF), Ras disabling form GDP, RasGAP acts as a major effector of Ras in tumor cells involving new signaling pathways. The innovative approach to validate the inhibition of molecular interactions of the protein RasGAP is the selection of peptidic aptamers, which we have developed against its SH3 domain. We used a combinatorial approach of the peptide aptamer to select a collection of specific peptides against the RasGAP-SH3 domain. We have mapped the binding sites of aptamer in the presence of a SH3-RasGAP mutation system in yeast double hybrid (AptaPrint). We studied the biological effect of the RG 27 aptamer, which target a pocket bounded by residues D295/7, L313 and W317. This aptamer has anti-proliferative and anti-apoptotic effect which is not dependent on caspases in tumor cells. RG27 inhibits the RasGAP and Aurora B interactions. In the second part, we described SH3 domain of RasGAP as a new target and studied its interaction with the small common subunit ubiquitous calpains (Capns1). This small sub-unit is a partner in the SH3 domain of RasGAP. The interaction between RasGAP and Capns1 is highlighted by co-immunoprecipitation and RasGAP pull-down and confocal microscopy. We have precisely studied the migration of PC3 cells (Raswt) and PC3-RasV12, which expresses a stable oncogenic Ras that is mostly found in human cancers. The SH3-RasGAP/Capns1 complex is found increased by a factor of 2 in cells PC3-RasV12 protrusions in contrast to parental PC3. In this complex, siRNA RasGAP disrupts cell migration and apoptosis RasV12 harboring cells, indicating that RasGAP acts as effector of Ras
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2

Amini, Mandana. "Analysis of Conditional Knock-out of Calpain Small Subunit, capns1, in Central Nervous System Development and Function". Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31360.

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Calpains, a highly conserved family of calcium-dependent cysteine proteases, are divided in two groups; classical and non-conventional calpains. Calpain-1 and calpain-2, the classical ones, are ubiquitously expressed and abundant in the CNS. Findings through different experimental approaches, predominantly pharmacological calpain inhibitors, proposed the necessity of the proteases for the modulation of various biological events particularly in the CNS, or a functional link between calpain and neurodegeneration. Significant functions associated with calpain activity are neuronal proliferation/differentiation, signal transduction, apoptosis, and synaptic plasticity; or neuronal death in Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and ischemic stroke. However, due to limited insights of the approaches taken, such as non-specificity of the inhibitors, the exact roles of calpains in the CNS and the key mechanisms underlying them remain controversial. Calpain-1/calpain-2 germline knock-out are embryonic lethal at a very early stage hindering the use of these lines as mouse models for CNS studies. Accordingly, this thesis research introduced a unique brain-specific calpain-1/calpain-2 knock-out and explored the role of the proteases in brain development/function and in neuronal death. The first set of analyses examined how the elimination of calpain-1/calpain-2 activities in mouse brain impacts CNS development in general and synaptic plasticity in CA1 neurons of hippocampus. CNS-specific elimination of CAPNS1, the common small subunit, abolished calpain-1/calpain-2 activities in mouse brain. In contrast to Calpain-1/calpain-2 germ line knock-outs, the brain-specific knock-outs are viable and the general development of mouse brain is normal. However, morphology of dendrites in pyramidal neurons of the hippocampal CA1 region showed significantly decreased dendritic branching complexity and spine density. Consistent with dendrite morphological abnormalities, electrophysiological analyses revealed a significant decrease in field excitatory postsynaptic potentials, long term potentiation, and learning and memory in the hippocampal CA1 neurons of the mutants. In the second part of this research we investigated the direct role of the calpains in neuronal death and their potential downstream targets in in vitro models of PD and ischemic stroke. Our findings indicated that ablation of calpains activity improves survival of different types of neurons against mitochondrial toxin 1-methyl-4-phenylpyridinium (MPP+), glutamate, and hypoxia. Importantly, we demonstrated an increase in p35-cleavage to p25, a cyclin dependent kinase 5 (Cdk5) activator, and that restoration of p25 significantly suppresses the neuronal survival associated with calpain deficiency. Taken together, this work unequivocally establishes two central roles of calpain-1/calpain-2 in CNS function in plasticity and neuronal death.
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3

Nettersheim, Jo-Ann. "Interplay between the translesion DNA polymerase η and the calpain system". Electronic Thesis or Diss., Strasbourg, 2020. http://www.theses.fr/2020STRAJ078.

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L’ADN est constamment altéré du fait du métabolisme oxydatif de la cellule ou de l’exposition à des agents génotoxiques. Malgré l’existence de systèmes de réparation efficaces, certaines lésions présentes lors de la phase S bloquent la progression des fourches de réplication. La synthèse translésionnelle (TLS) permet la reprise de la réplication. Pol η est une ADN polymérase TLS capable de franchir et sans erreur les lésions induites par les UV mais pol η est mutagène lorsqu’elle réplique l'ADN non endommagé. Par conséquent, son activité doit être strictement régulée. La thèse présente l’étude de l’interaction entre pol η et CAPNS1, la sous-unité des calpaïnes 1 et 2. Ces protéases ubiquitaires dépendantes du calcium régulent de nombreux processus cellulaires. Nous montrons que CAPNS1 est colocalisée avec pol η dans le noyau. La calpaïne clive pol η in vitro et in vivo après l’acide aminé 465, laissant le domaine catalytique intact et le motif PIP1. De manière surprenante, l'inhibition de la calpaïne entraîne une diminution de la formation de foyers pol η et de la survie cellulaire. Ces résultats suggèrent que la calpaïne est impliquée dans la TLS dépendante de pol η
Cells are constantly exposed to DNA damaging agents causing lesions, which are repaired by a range of DNA repair pathways. If DNA damages prevail during replication, they can cause replication fork breakdowns and mutations. One mechanism to prevent this is the translesion synthesis (TLS). Pol η is a translesion DNA polymerase which is capable to circumvent UV-induced lesions, to be repaired at a later time. However, pol η is error prone on non-damaged DNA and, therefore, needs to be tightly regulated. This thesis present an interaction between pol η and CAPNS1 and our investigation of its role in regulating pol η. CAPNS1 is the small subunit of the calcium dependent calpain 1 and 2. We demonstrate that CAPNS1 is colocalized with pol η in the nucleus and calpain 1/2 can cleave pol η in vitro and in vivo. The proteolysis of pol η is found to occur at position 465 leading to a truncated protein encompassing the catalytic domain and the PIP1 motif. Interestingly, inhibition of calpain leads to a perturbed pol η foci formation and decreased cell survival. Taken together, these results suggest an important positive role for calpain in pol η dependent TLS
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4

Villarejo, Reina Bohores. "Synthesis of defect free YBa2Cu3O7-x films over 1µm by CSD using inkjet printing". Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/664222.

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El descubrimiento de los superconductores de alta temperatura (HTS) han supuesto un gran paso en el desarrollo de la tecnología energética. Entre ellos, el YBa2Cu3O7-x (YBCO) epitaxial, ha demostrado una de las mejores propiedades superconductoras, haciendo de este óxido funcional, uno de los superconductores más estudiados. La deposición química de disolución (CSD) se presenta como una metodología de bajo coste para la síntesis de una gran variedad de óxidos funcionales, incluyendo el YBCO. Esta técnica consiste en la deposición de un precursor organometálico sobre un sustrato texturado, seguido por un tratamiento térmico para pasar de la solución depositada a una cerámica densa y cristalina de YBCO. Además del bajo coste de la CSD, esta metodología permite una alta flexibilidad y control durante la síntesis de la solución, haciendo de esta ruta sintética, una perfecta candidata para la producción de YBCO a gran escala en un proceso competitivo a nivel de mercado. Para la deposición de la solución precursora de YBCO, presentamos la tecnología Inkjet Prining drop on demand como una técnica perfectamente adaptada a la síntesis de capas de YBCO. La gran flexibilidad y control de deposición, junto con la posibilidad de escalar esta técnica, hacen del Inkjet Printing una candidata perfecta para la producción de capas de YBCO por CSD. Para poder transportar grandes cantidades de energía, las capas de YBCO deben ser gruesas. Sin embargo, conseguir grosores elevados es el principal problema de la CSD. La enorme reducción de grosor que se da durante la combustión de la materia orgánica, en el proceso conocido como pirolisis, produce un estrés enorme que lleva al agrietamiento de la capa cuando esta sobrepasa unos pocos centenares de nanómetros. Esto ha forzado a muchos investigadores a conseguir aumentar el grosor de la capa mediante multicapas delgadas para evitar las grietas. Este proceso no solo ralentiza la producción, sino que también degrada las propiedades superconductoras debido a la acumulación de cobre que se observa en las interfaces. Así pues, el objetivo en esta tesis es el de conseguir capas del mayor grosor posible en un solo recubrimiento por tal de maximizar las propiedades superconductoras del YBCO en un proceso rápido y de bajo coste. Para conseguir este objetivo, nos hemos centrado en el estudio de la deposición por Inkjet Printing y pirolisis de las tintas precursoras de YBCO. A continuación resumimos los principales puntos que vamos a tratar en esta tesis: 1 Hemos diseñado tintas precursoras de YBCO adaptadas para ser depositadas por Inkjet Printing. La deposición de dichas tintas se ha estudiado por tal de obtener capas gruesas y homogéneas. 2 Hemos realizado un análisis exhaustivo de las diferentes propiedades físico-químicas de la capa durante el proceso de pirolisis por tal de evitar la formación de grietas en nuestras capas. 3 Hemos usado el conocimiento adquirido durante los dos puntos previos para obtener capas que sobrepasan la micra de grosor en un solo recubrimiento de YBCO sobre diferentes tipos de sustrato de modo reproducible, demostrando así la alta competitividad de la metodología CSD en la síntesis de capas de YBCO.
The discovery of the High Temperature Superconductors (HTS) supposed a giant stride on the power applications technological development. Among them, the c-oriented, epitaxial YBa2Cu3O7-x (YBCO) presents top-tier superconducting performances, making of this complex oxide one of the most studied superconductors. Chemical Solution Deposition (CSD) is presented as a low cost manufacturing methodology for the synthesis of many functional oxides, including YBCO. It consists on the deposition of an organometallic precursor solution on top of a textured substrate, followed by a thermal treatment to pass from the deposited solution to the dense, crystalline YBCO. Besides of the low cost of the CSD, this methodology allows a high flexibility and control during the solution synthesis, making of this synthetic route a perfect candidate for the YBCO large scale production in a cost effective process. For the deposition of YBCO precursor solutions, we present drop on demand Inkjet Printing technology as a deposition technique perfectly suited for the YBCO films synthesis. The high flexibility and deposition control, together with the scalability of the technique, makes of inkjet printing an appealing technology for the production of long length YBCO films by CSD. In order to transport large amounts of power, the YBCO films must be thick. However to achieve high thickness is the main challenge of the CSD route. The huge thickens reduction produced during the firing of the organic species, also known as pyrolysis process, produces high stresses that leads to the film cracking when the thickness surpasses a few hundreds of nanometres. This has forced many researchers to increase the film thickness by the multi-processing of thin films in order to avoid the film cracking. This is not only time-expensive, but it also leads to the superconducting properties degradation due to the presence of copper segregated interlayers. Thus, objective of this work was to achieve the largest thickness in one single coating, in order to maximize the YBCO superconducting performances in a fast, low-cost process. To achieve this, we focused in the study of the deposition and pyrolysis of YBCO precursor inks deposited by inkjet printing. What we will present on along this thesis is briefly described as follows: 1 We have designed YBCO precursor inks suited for its deposition using inkjet printing. The deposition of these inks has been studied in order to obtain thick and homogeneous depositions. 2 We have performed an exhaustive analysis on the different physicochemical properties of the film during the pyrolysis process in order to avoid the crack formation. 3 We have used the knowledge generated during the two previous points in order to surpass the micrometre thickness on one single coated YBCO films on top of several substrates in a reproducible way, and thus demonstrating that the high competitiveness of the CSD process for the synthesis of YBCO films.
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Longuépée, Hugues. "Sédimentation en marge d'un promontoire cambro-ordovicien : le groupe d'Ile d'Orléans, Appalaches du Québec /". Thèse, Chicoutimi : Université du Québec à Chicoutimi, 2005. http://theses.uqac.ca.

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Ścigaj, Mateusz. "Functional oxide films and interfaces: ferroelectric BaTiO3 films on Si(001) and conducting (110) and (111) LaAlO3/SrTiO3 interfaces". Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/400603.

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La tesis aborda la integración monolítica de óxidos funcionales sobre silicio y la exploración de intercaras entre SrTiO3(110), SrTiO3(111) y otros óxidos En primer lugar la tesis detalla la integración monolítica del BaTiO3 en silicio, la plataforma actual en microelectrónica. Para ello se ha usado la heteroestructura LaNiO3/CeO2/YSZ como capa de barrera química y acomodación estructural. Se han investigado las propiedades estructurales y funcionales. Las capas son epitaxiales y orientadas con el eje c perpendicular al substrato, y presentan rugosidad superficial muy baja y alta polarización ferroeléctrica en remanencia. El óxido ferrimagnético CoFe2O4 fue integrado seguidamente en la estructura. La estructura multifuncional obtenida presenta alta calidad estructural, con excelentes propiedades ferromagnéticas y ferroeléctricas a temperatura ambiente. Asimismo presentamos la integración de BaTiO3 epitaxial sobre Si usando SrTiO3 como capa de barrera. También en este caso los ciclos de polarización ferroeléctrica medidos señalan las buenas propiedades funcionales de la estructura. Se presenta una comparación de las propiedades estructurales y funcionales de BaTiO3 crecido sobre SrTiO3/Si(001) y sobre CeO2/YSZ/Si(001). La segunda parte de la tesis se centra en las propiedades estructurales y de transporte de intercaras de LaAlO3/SrTiO3, con un especial énfasis en el estudio de la formación de un gas bidimensional de electrones en la intercara LaAlO3/SrTiO3(110). El análisis de la estructura y química de la intercara, de su jerarquía orbital electrónica, y de sus propiedades superconductoras amplían el conocimiento existente de los gases bidimensionales de electrones en intercaras de óxidos. Se han estudiado también las intercaras conductoras entre SrTiO3(110) y óxidos amorfos. El estudio ha permitido determinar la importancia relativa de la afinidad con el oxígeno de los metales depositados y la dependencia con la orientación de la energía de formación y difusión de vacantes de oxígeno. Además la tesis detalla el crecimiento monocapa a monocapa de Y:ZrO2 sobre SrTiO3(110), dando lugar a la relación epitaxial [110]YSZ(001) //[001]SrTiO3(110). Representa una nueva intercara presentando discontinuidad de simetría sin presentar variantes cristalinas gracias a usar la superficie de menor simetría como substrato, y abre paso al desarrollo de otras intercaras originales entre óxidos.
In this thesis the focus was aimed to the monolithic integration of functional oxides on silicon and to the exploration of interfaces between different oxides and the SrTiO3(110) and SrTiO3 (111) surfaces. Herein we report the monolithic integration of ferroelectric BaTiO3 on silicon, the current platform for microelectronics. This was done using the LNO/CeO2/YSZ buffer layer. The structural and functional properties are investigated. The films are epitaxial an c-oriented. Very low surface roughness and high ferroelectric remanent polarization are reported. High crystal quality ferrimagnetic CoFe2O4 was subsequently integrated in the structure. Thus obtained multifunctional structure shows high structural quality, robust ferromagnetism and superior ferroelectric properties, all at room temperature. Moreover, we report the integration of epitaxial BaTiO3 on Si using SrTiO3 buffer layer. Also in this case the recorded ferroelectric loops point to the good functional properties of this structure. A structural and functional comparison is given between BTO grown on the thin SrTiO3 and CeO2/YSZ buffer layers on silicon. We also report on the structural and transport properties of LaAlO3/SrTiO3 interfaces, with special emphasis on the LaAlO3/SrTiO3(110) interface featuring two-dimensional electron gas (2DEG). Further analysis of the interface structure and chemistry, electronic orbital hierarchy and superconductivity enriched our knowledge of the 2DEG electronic properties. Special focus also was given to the conductive interfaces comprising SrTiO3(110) and amorphous oxides. This study enables us to disentangle the relative importance of the oxygen affinity of the deposited metals and the orientation-dependent energy of vacancy formation and diffusion on the creation of oxygen vacancies. In addition we report the layer by layer growth of Y:ZrO2 on SrTiO3(110), leading to the epitaxial relationship [110]YSZ(001) //[001]SrTiO3(110). This novel idea of an interface featuring a symmetry discontinuity with the substrate being the lower symmetry material paves the way towards development of other innovative oxide interfaces.
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Schreiber, Henry. "CAPES AND DIAPERS". Master's thesis, University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2680.

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By fusing classical imagery with passions and vicissitudes of the contemporary world, I create images that are technically sound yet riddled with both overt and subtle humor. These paintings are intended to illuminate the futility of guilt and frustration we encounter in the struggle for identity and meaning by arousing laughter, indignation, curiosity, and finally recognition.
M.F.A.
Department of Art
Arts and Humanities
Studio Art and the Computer MFA
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Butt, Ali Muhammad. "New Photonic devices based on NLO(non-linear optical) crystalline waveguides". Doctoral thesis, Universitat Rovira i Virgili, 2015. http://hdl.handle.net/10803/403372.

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El RbTiOPO4 és un cristall de òptica no lineal amb alts coeficients electró-òptics i un llindar de dany òptic elevat, això el converteix en un material potencial per aplicacions electro-òptiques. Actualment hi ha un interès en el desenvolupament de components òptics basats en materials dielèctrics, identificat com un tema de recerca punter per Europa Horitzó 2020. La finalitat d’aquesta tesis és explorar el RTP com a plataforma dielèctrica per dispositius fotònics, que tenen aplicacions en les telecomunicacions i en el sensat biològic. En aquesta tesis s’han crescut materials monocristal•lins en volum de RTP, K:RTP i Na:KTP pel mètode de Top seeded solution growth. Els cristalls obtinguts són òptims per ser utilitzats com a plataforma per fabricar guies d’ona i com a substrats pel creixement de capes epitaxials. Capes epitaxials de (Yb,Nb):RTP sobre RTP(001), RTP sobre K:RTP(001) i K.:RTP(100), i KTP sobre Na:KTP(001) s’han crescut per la metodologia de liquid phase epitaxy. Aquesta metodologia ha permès obtenir capes monocristal•lines amb una interfase d’alta qualitat cristal•lina La fabricació de guies d’ona ha esta realitzada per RIE i ICP-RIE. Es reporta en aquesta tesis, un avanç en el coneixement del procés de etching del RTP. El mètode d’intercanvi iònic, amb Cs+ com ió, s’ha utilitzat per produir guies rectes, corbes i MZ. Degut a l’alta conductivitat iònica del RTP al llarg de la direcció c cristal•logràfica, l’ intercanvi iònic és altament factible i gairebé unidireccional. S’ha obtingut exitosament el procés de guiat de llum en totes les guies d’ona fabricades. Pels Y-splitters i els MZ fabricats sobre els cristalls RTP/(Yb,Nb):RTP/RTP(001) estructurats amb RIE sobre la capa activa o bé el substrat, la guia obtinguda és monomode amb polarització TM a 1550 nm. Les pèrdues de propagació són de 3.5 dB/cm. Per les guies d’ona rectes fabricades sobre RTP/(Yb,Nb):RTP/RTP(001) per estructuració del recobriment per ICP-RIE, les pèrdues de propagació són 0.376 dB/cm a 1550 nm.
El RbTiOPO4 es un cristal de óptica no-lineal con altos coeficientes electro ópticos y un límite de daño óptico elevado, eso lo convierte en una potencial material para aplicaciones electrópticas. Actualmente existe un gran interés en el desarrollo de componentes ópticos basados en materiales dieléctricos, esto ha sido identificado como un tema puntero de investigación por Europa Horizonte 2020. La finalidad de esta tesis es explorar el RTP cómo plataforma dieléctrica para dispositivos fotónicos, que tienen aplicaciones en les telecomunicaciones y en el sensado biológico. En esta tesis, se han crecido materiales monocristalinos en volumen de RTP, K:RTP y Na:KTP por el método de Top seeded solution growth. Los cristales crecidos son óptimos para ser utilizados como plataforma para fabricar guías de onda y como sustratos para el crecimiento de capas epitaxiales. Capas epitaxiales de (Yb,Nb):RTP sobre RTP(001), RTP sobre K:RTP(001) yK.:RTP(100), i KTP sobre Na:KTP(001) se han crecido mediante la metodología de liquid phase epitaxy. Esta metodología ha permitido obtener capes monocristalinas con una interfase de alta calidad cristalina. La fabricación de guías de onda se ha hecho por RIE y ICP-RIE: Se reporta en esta tesis un avance en el conocimiento del proceso de etching en el RTP. El método de intercambio iónico, con Cs+ como ion, se ha utilizado para producir guías de onda rectas, curvas y MZ. Debido a la alta conductividad iónica del RTP a lo largo de la dirección c cristalográfica, el intercambio iónico es altamente factible y casi unidireccional. Se ha obtenido el guiado con éxito en todas las guías de onda fabricadas. En los Y-Splitters y MZ fabricados sobre los cristales RTP/(Yb,Nb):RTP/RTP(001) estructurados con RIE sobre la capa activa o bien el sustrato, la guía obtenida es monomodo con la polarización TM a 1550 nm. Las pérdidas de propagación son de 3.5 dB/cm. Para las guías de onda rectes fabricadas sobre RTP/(Yb,Nb):RTP/RTP(001) por estructuración del recubrimiento por ICP-RIE, las pérdidas por propagación son de 0.376 dB/cm a 1550 nm.
RbTiOPO4 is a non-linear optical crystal with high electro-optic coefficients and high optical damage threshold, which makes it suitable for electro-optic applications. There’s a current interest in developing dielectric based photonic components for integrated optics, identified as a topic of research by the Europe Horizon 2020. The aim of this thesis is to explore RTP for dielectric based photonic platforms, which have applications in telecommunications and biosensing. In this thesis is reported the successful grow of bulk single crystals of RTP, K:RTP and Na:RTP by Top Seeded Solution Growth technique. The crystals obtained are suitable to be used as platforms to fabricate optical waveguides and for substrates for growth of epitaxial layers. Epitaxial layers of (Yb,Nb):RTP were grown on RTP(001), RTP was grown on K:RTP(001) and K:RTP(100) and KTP was grown on Na:KTP(001) by Liquid phase epitaxy. This methodology allows obtaining a single crystalline layer, with high quality crystalline interface. Waveguide fabrication was performed by RIE and ICP-RIE. Advancement in this etching process on RTP is reported in this thesis. Cs+ ion exchange method was used to produce straight, bends and MZ waveguides. Due to the RTP high ionic conductivity along the c crystallographic direction, ion exchange is highly feasible and almost unidirectional. Waveguiding of the fabricated channel waveguides has been successful. For the Y-Splitter and MZ waveguides fabricated on the RTP/(Yb,Nb):RTP/RTP(001) crystals, by structuring the active layer or the substrate by RIE, the waveguides obtained were single mode in TM polarization at 1550 nm. The propagation loss was 3.5 dB/cm. For straight waveguides fabricated on the RTP/(Yb,Nb):RTP/RTP(001), by structuring the cladding by ICP-RIE, the propagation losses were 0.376 dB/cm at 1550 nm. The waveguides fabricated by Cs+ ion exchange have larger losses due to inhomogeneity on the Cs exchange among different ferroelectric domains present in the structure.
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Capps, Denny Lane. "The Quaternary history of the Cordilleran Ice Sheet fringe Ashley Lake area, Montana /". Thesis, Montana State University, 2004. http://etd.lib.montana.edu/etd/2004/capps/CappsD04.pdf.

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Dutra, Sigrid Karin Weiss. "Portal de Periódicos da CAPES". Florianópolis, SC, 2005. http://repositorio.ufsc.br/handle/123456789/102324.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção
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A pós-graduação brasileira, com a mudança ocorrida no Programa de Aquisição de Periódicos - PAAP, a partir de 1998 sofreu um grande impacto, primeiramente com o corte no orçamento e conseqüente redução de títulos assinados e na seqüência com a substituição das assinaturas de periódicos impressos pelos periódicos eletrônicos. Esta dissertação, caracterizada como um estudo exploratório, descritivo e avaliativo, a partir de uma pesquisa qualitativa analisa o comportamento dos alunos e professores de pós-graduação da UFSC frente à estas mudanças. Apresenta fundamentação teórica caracterizando a biblioteca universitária como unidade de informação e um panorama das Bibliotecas Universitárias brasileiras, tratando ainda da evolução histórica da tecnologia da informação e suas conseqüências no meio acadêmico e nas bibliotecas universitárias. Caracteriza a pós-graduação no contexto da UFSC, seu histórico e oferta em 2003, bem como, caracteriza ainda, o PAAP e o Portal de Periódicos CAPES. A metodologia empregada foi a técnica de coleta de dados, observação, análise documental, pesquisa bibliográfica e aplicação de um questionário. Conclui que as mudanças introduzidas no PAAP revolucionaram a forma de acesso à informação científica e tecnológica, apresentando um cenário positivo na aceitação e uso de novas tecnologias. A pesquisa evidenciou resistência inicial ao novo modelo do PAAP e mostrou que uma parcela considerável de usuários desconhecem os recursos disponíveis no Portal de Periódicos e indica que a biblioteca ainda é imprescindível para a realização das pesquisas apontando para a importância para o papel de mediação do bibliotecário. O objetivo proposto foi alcançado e possibilitou o desenvolvimento de um estudo de caso na UFSC, em relação ao uso do Portal de Periódicos da CAPES que pode servir de subsídio para implementação de melhorias na divulgação e capacitação de usuários e contribuir com o estabelecimento de políticas públicas para as bibliotecas universitárias e para o acesso a informação científica e tecnológica.
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Libros sobre el tema "CAPNS1"

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Lengler, Evelyn. Capuns. Chur: Desertina, 1999.

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Lengler, Evelyn. Capuns. Chur: Desertina, 1999.

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Calvano, Sergi Santjoan. Capsa sorpresa. Barcelona: Proa, 2007.

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Clark, Cheryl. Great capes. New York: Workman Publishing, 1998.

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Busino, Jean-Jacques. Le bal des capons. Paris: Payot & Rivages, 1997.

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Works, Tasmania Parliament Standing Committee on Public. Three Capes Track. [Hobart, Tasmania]: [Parliament House], 2012.

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Verger, Guillem. Capsa de Borbons. [Barcelona]: Fil d'Aram, 2011.

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Dalmau, Antoni. Capsa de records. Barcelona: Columna, 1995.

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Caps. New York: Cader Books, 1996.

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Daniels, Ethan. Seas capes: Coral triangle. Singapore: Asian Geographic, 2012.

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Capítulos de libros sobre el tema "CAPNS1"

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Azimova, Shakhnoza S. y Anna I. Glushenkova. "Colodenbrum capense Thunb." En Lipids, Lipophilic Components and Essential Oils from Plant Sources, 826. London: Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_2668.

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Kramp, Joseph M. "Capps, Donald". En Encyclopedia of Psychology and Religion, 353–56. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-24348-7_9129.

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Kramp, Joseph M. "Capps, Donald". En Encyclopedia of Psychology and Religion, 281–84. Boston, MA: Springer US, 2014. http://dx.doi.org/10.1007/978-1-4614-6086-2_9129.

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Bussmann, Rainer W., Narel Y. Paniagua-Zambrana y Grace N. Njoroge. "Piper capense L. Piperaceae". En Ethnobotany of the Mountain Regions of Africa, 1–6. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-77086-4_123-1.

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Bussmann, Rainer W., Narel Y. Paniagua-Zambrana y Grace N. Njoroge. "Piper capense L. Piperaceae". En Ethnobotany of the Mountain Regions of Africa, 825–30. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-38386-2_123.

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Bhutiyani, Mahendra R. "Ice Caps". En Encyclopedia of Earth Sciences Series, 582–83. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-90-481-2642-2_256.

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El-Metwally, Salah El-Din E. y Wai-Fah Chen. "Pile Caps". En Structural Concrete, 185–224. Boca Raton : CRC Press, 2017.: CRC Press, 2017. http://dx.doi.org/10.4324/9781315155500-8.

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El-Metwally, Salah El-Din E. y Wai-Fah Chen. "Pile Caps". En Structural Concrete, 185–224. Taylor & Francis Group, 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742: CRC Press, 2017. http://dx.doi.org/10.1201/9781315155500-9.

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Bowers, Michael, Dionysios Synodinos y Victor Sumner. "Drop Caps". En Pro HTML5 and CSS3 Design Patterns, 427–45. Berkeley, CA: Apress, 2011. http://dx.doi.org/10.1007/978-1-4302-3781-5_18.

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Payne, Christopher y Andrew Kjos. "Bald Caps". En A Beginner’s Guide to Special Makeup Effects, 65–70. New York : Routledge, 2021.: Routledge, 2021. http://dx.doi.org/10.4324/9781003093701-15.

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Actas de conferencias sobre el tema "CAPNS1"

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Rapp Christina, K., AlexV Postma, Katrin Knoflach, AlexanderE Volk, JohannesR Lemke, Maximilian Ackermann, Nicolas Regamey et al. "Biallelic variants in the calpain regulatory subunit, CAPNS1, cause pulmonary arterial hypertension". En 44. Jahrestagung der Gesellschaft für Pädiatrische Pneumologie. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1761555.

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Burtsev, Anton, David Johnson, Josh Kunz, Eric Eide y Jacobus Van der Merwe. "CapNet". En SoCC '17: ACM Symposium on Cloud Computing. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3127479.3131209.

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SILVA, Juliana Barbosa e. y Leonor Bezerra GUERRA. "La Minoridad Penal: breves aportes de las neurociencias en discusiones actuales sobre la responsabilidad penal juvenil". En Congreso Argentino de Psicologia 2016. Recife, Brasil: Even3, 2016. http://dx.doi.org/10.29327/xvi-cap.a1.

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Millen, Jonathan K. "CAPSL". En the 1996 workshop. New York, New York, USA: ACM Press, 1996. http://dx.doi.org/10.1145/304851.304879.

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Li, Yan, Kenneth Chang, Oceane Bel, Ethan L. Miller y Darrell D. E. Long. "CAPES". En SC '17: The International Conference for High Performance Computing, Networking, Storage and Analysis. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3126908.3126951.

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DeVos, Leon y Bob Hasara. "Field Applications with CAPSY". En 10th International Symposium on Automation and Robotics in Construction. International Association for Automation and Robotics in Construction (IAARC), 1993. http://dx.doi.org/10.22260/isarc1993/0060.

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Emara, Karim, Wolfgang Woerndl y Johann Schlichter. "CAPS". En WiSec'15: 8th ACM Conference on Security & Privacy in Wireless and Mobile Networks. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2766498.2766500.

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Inst. of Animation, Visual Effects. "CAPs". En ACM SIGGRAPH 2006 Computer animation festival. New York, New York, USA: ACM Press, 2006. http://dx.doi.org/10.1145/1179196.1179210.

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Dhruv, Bansal y Peukert Thomas. "CAPS". En Association of British Neurologists: Annual Meeting Abstracts 2023. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jnnp-2023-abn.258.

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Strenzke, N., L. Tranebjærg y M. Bitner-Glindzicz. "Auditorische Neuropathie bei CAPOS-Syndrom". En Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640630.

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Informes sobre el tema "CAPNS1"

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Schickel, Robert y Marcus Peter. The Role of Capase-8 in Breast Carcinoma Cells. Fort Belvoir, VA: Defense Technical Information Center, abril de 2005. http://dx.doi.org/10.21236/ada435285.

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Barnhart, Bryan C. y Marcus E. Peter. The Role of Capase-8 in Breast Carcinoma Cells. Fort Belvoir, VA: Defense Technical Information Center, abril de 2004. http://dx.doi.org/10.21236/ada424040.

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Schickel, Robert y Marcus E. Peter. The Role of Capase-8 in Breast Carcinoma Cells. Fort Belvoir, VA: Defense Technical Information Center, abril de 2006. http://dx.doi.org/10.21236/ada463469.

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หนูจักร, ธรรมนูญ y อมร เพชรสม. การพัฒนาวิธีการวิเคราะห์และการหาปริมาณแคปไซซินและไดไฮโดรแคปไซซิน ในผลิตภัณฑ์พริกและอาหารรสเผ็ด : รายงานการวิจัยฉบับสมบูรณ์ ปีที่ 3 (ต.ค. 2551 ถึง ก.ย. 2552) ( Development of analytical methods and determination of capsaicin and dihydrocapsaicin in chili products and hot spicy food). จุฬาลงกรณ์มหาวิทยาลัย, 2009. http://dx.doi.org/10.58837/chula.res.2009.1.

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ได้ประยุกต์วิธีการเตรียมตัวอย่างและเทคนิคไมเซลลาร์อิเล็กโทรไคเนทิกโครมาโทกราฟี (MEKC) ที่พัฒนาขึ้นในงานวิจัยก่อนหน้านี้ สำหรับการวิเคราะห์ปริมาณแคปไซซินอยด์ (CAPs) ในตัวอย่างจริงที่เป็นซอสพริกและเครื่องแกงสำเร็จรูป เมื่อใช้การทดสอบทางสถิติด้วยวิธี paired t-test ที่ระดับความเชื่อมั่น 95 % พบว่าปริมาณของ CAPs ในซอสพริก 9 ตัวอย่างที่วิเคราะห์ได้ด้วยเทคนิค MEKC และ HPLC ไม่มีความแตกต่างอย่างมีนัยสำคัญ จากการวิเคราะห์ด้วย MEKC ปริมาณ CAPs ที่พบในซอสพริก 22 ตัวอย่าง อยู่ในช่วง 13 ถึง 262 ppm และปริมาณ CAPs ในเครื่องแกงสำเร็จรูป 5 ตัวอย่าง อยู่ในช่วง 41 ถึง 140 ppm โดยที่ซอสพริก 7 ตัวอย่าง และเครื่องแกงสำเร็จรูป 4 ตัวอย่าง มีปริมาณ CAPs มากกว่า 50 ppm (mg/kg) ซึ่งเป็นปริมาณจำกัดที่สหภาพยุโรป แนะนำ ในอาหารเผ็ดจัด นอกจากนี้ปริมาณ CAPs ที่วิเคราะห์ได้จากต่างยี่ห้อกันไม่มีความสัมพันธ์กับปริมาณพริกและระดับความเผ็ดที่ระบุไว้ ดังนั้น MEKC และวิธีการเตรียมตัวอย่างที่พัฒนาขึ้นนี้จึงเป็นอีกทางเลือกหนึ่งของการวิเคราะห์ปริมาณ CAPs เพื่อควบคุมคุณภาพของผลิตภัณฑ์และเป็นข้อมูลความปลอดภัยของผู้บริโภคได้
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หนูจักร, ธรรมนูญ, อมร เพชรสม y วาสนา โตเลี้ยง. การพัฒนาวิธีการวิเคราะห์และการหาปริมาณแคปไซซินและไดไฮโดรแคปไซซิน ในผลิตภัณฑ์พริกและอาหารรสเผ็ด : รายงานฉบับสมบูรณ์ ปี 2551 ( Development of analytical methods and determination of capsaicin and dihydrocapsaicin in chili products and hot spicy food). จุฬาลงกรณ์มหาวิทยาลัย, 2008. http://dx.doi.org/10.58837/chula.res.2008.1.

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งานวิจัยนี้ได้พัฒนาวิธีการเตรียมตัวอย่างซอสพริก สำหรับปริมาณวิเคราะห์แคปไซซินอยด์ (CAPs) ด้วยเทคนิคไมเซลลาร์อิเล็กโทรไคเนทิกโครมาโทกราฟี (MEKC) ที่ได้พัฒนาแล้วจากงานวิจัยก่อนหน้านี้ โดยศึกษาและเปรียบเทียบผลของชนิดของตัวทำละลายอินทรีย์ที่ใช้สกัด (เอทิลอะซิเตตหรืออะซิโตไนไทรล์) แบบที่เติมเกลือและไม่เติมเกลือ พบว่าการสกัดตัวอย่างด้วยเอทิลอะซิเตตแบบเติมเกลือให้ประสิทธิภาพของการสกัด CAPs ที่ดีกว่า เมื่อศึกษาการสกัดด้วยวิธีนี้ โดยใช้ซอสพริกเตรียมที่ประกอบด้วย CAPs ที่ 20, 50 และ 100 ppm (µg/g) พบว่าได้ recovery ในช่วง 96-105% แสดงว่ามีความเที่ยงสูงทั้งภายในวัน (RSD <3.7%, n=5 batch) และต่างวันกัน (RSD <2.5%, เป็นเวลา 5วัน) เมื่อวิเคราะห์ตัวอย่างซอสพริกจริง 8 ตัวอย่าง ด้วย MEKC โดยเตรียมตัวอย่างด้วยวิธีที่พัฒนาขึ้น พบว่ามีปริมาณ CAPs ในช่วง 21-128 ppm โดยที่ 3 ตัวอย่างมีปริมาณ CAPs มากกว่า 50 ppm ซึ่งเกินปริมาณจำกัดของสหภาพยุโรป (European Commission) นอกจากนี้ปริมาณ CAPs ที่วิเคราะห์ได้จากต่างยี่ห้อกันไม่มีความสัมพันธ์กับปริมาณพริกในซอสพริกและระดับความเผ็ดที่ระบุไว้ ดังนั้น MEKC และวิธีการเตรียมตัวอย่างที่พัฒนาขึ้นนี้จึงเป็นอีกทางเลือกหนึ่งของการวิเคราะห์ปริมาณ CAPs ในซอสพริก เพื่อควบคุมคุณภาพของผลิตภัณฑ์และเป็นข้อมูลความปลอดภัยของผู้บริโภคได้
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Riggio, Maria A. CAPS 2014 Benchmark Report. Office of Scientific and Technical Information (OSTI), noviembre de 2014. http://dx.doi.org/10.2172/1561685.

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Lusk, Steve, David Lawrence y Prakash Suvana. Cyber-intrusion Auto-response and Policy Management System (CAPMS). Office of Scientific and Technical Information (OSTI), noviembre de 2015. http://dx.doi.org/10.2172/1329008.

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Whitbeck, George S. y Man-Tak Shing. CAPS and Real-Time Systems. Fort Belvoir, VA: Defense Technical Information Center, septiembre de 1996. http://dx.doi.org/10.21236/ada315954.

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Walker, Shelly. Fog, Friction and Force Caps. Fort Belvoir, VA: Defense Technical Information Center, mayo de 2003. http://dx.doi.org/10.21236/ada420056.

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Denker, Grit, Jonathan Millen y Harald Rueess. The Common Authentication Protocol Specification Language (CAPSL) Integrated Protocol Environment. Fort Belvoir, VA: Defense Technical Information Center, diciembre de 2001. http://dx.doi.org/10.21236/ada399523.

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