Tesis sobre el tema "Cancer cachexia, metabolism, pyruvate"
Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros
Consulte los 16 mejores tesis para su investigación sobre el tema "Cancer cachexia, metabolism, pyruvate".
Junto a cada fuente en la lista de referencias hay un botón "Agregar a la bibliografía". Pulsa este botón, y generaremos automáticamente la referencia bibliográfica para la obra elegida en el estilo de cita que necesites: APA, MLA, Harvard, Vancouver, Chicago, etc.
También puede descargar el texto completo de la publicación académica en formato pdf y leer en línea su resumen siempre que esté disponible en los metadatos.
Explore tesis sobre una amplia variedad de disciplinas y organice su bibliografía correctamente.
Michele, Mannelli. "A metabolic change towards fermentation drives cancer cachexia in myotubes". Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1211634.
Texto completoWinter, Aaron. "Protein metabolism and insulin resistance in non-small cell lung cancer cachexia". Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97084.
Texto completoLa perte de poids et la résistance à l'insuline caractérisent la cachexie due au cancer. Un anabolisme protéique amoindri a été démontré dans des conditions d'insulino-résistance. Cette étude a évalué si l'hyperaminoacidemie et l'hyperinsulinemie résultent en un défaut de l'anabolisme protéique corporel dans la cachexie due au cancer du poumon « non à petites cellules » (NSCLC). La cinétique des protéines ([13C]leucine) et du [3H]glucose corporels ont été évalués chez 8 patients avec NSCLC et 10 hommes en santé, d'âge et de poids similaires, à l'aide du clamp hyperinsulinique, euglycémique, isoaminoacidémique (Iso-AA), suivi d'une hyperaminoacidémie (Hyper-AA). L'utilisation du glucose a augmenté entre Iso-AA et Hyper-AA, mais il était plus bas chez les patients NSCLC. Pendant Iso-AA, la dégradation des protéines a diminué et la synthèse n'a pas changé, résultant en une balance positive moindre chez les NSCLC. En Hyper-AA, la synthèse a augmenté, mais la dégradation n'a pas changé, ce qui a augmenté davantage la balance positive, dans les deux groupes. En résumé, les patients NSCLC perdant du poids ont démontré une résistance du métabolisme glucidique et protéique à l'insuline. L'hyperaminoacidémie a normalisé leur réponse anabolique à celle des contrôles sans affecter la sensibilité du glucose à l'insuline.
Tian, Min. "Dys-regulated Metabolism and Cardiac Dysfunction in A Mouse Model of Cancer Cachexia". The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1297196325.
Texto completoKooshan, Zeinab. "Nanoparticle assisted small molecule delivery to target prostate cancer metabolism". Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/228736/1/Zeinab_Kooshan_Thesis.pdf.
Texto completoMarco-Rius, Irene. "Preserving hyperpolarised nuclear spin order to study cancer metabolism". Thesis, University of Cambridge, 2014. https://www.repository.cam.ac.uk/handle/1810/245345.
Texto completoSchäfer, Michaela [Verfasser] y Stephan [Akademischer Betreuer] Herzig. "Tumor-borne mediators trigger heart atrophy and alter cardiac metabolism in cancer cachexia / Michaela Schäfer ; Betreuer: Stephan Herzig". Heidelberg : Universitätsbibliothek Heidelberg, 2015. http://d-nb.info/1180607945/34.
Texto completoMehrfar, Parisa. "Biological markers of weight loss and muscle protein metabolism in early non-small cell lung cancer". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116069.
Texto completoWojtkowiak, Jonathan W., Heather C. Cornnell, Shingo Matsumoto, Keita Saito, Yoichi Takakusagi, Prasanta Dutta, Munju Kim et al. "Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302". BioMed Central, 2016. http://hdl.handle.net/10150/610264.
Texto completoMartin, Agnès. "Role of the glucocorticoid pathway in skeletal muscle wasting and hepatic metabolism rewiring during cancer cachexia in ApcMin/+ mice – Functional implication of myostatin gene invalidation". Thesis, Lyon, 2020. http://www.theses.fr/2020LYSES034.
Texto completoCachexia affects about half of cancer patients and is characterized by a progressive body mass loss mainly resulting from skeletal muscle depletion. This loss of skeletal muscle mass together with a decrease in muscle force strongly contribute to reduce cancer patient quality of life, treatment efficiency and ultimately patient survival. Many factors are known to be involved in the regulation of skeletal muscle homeostasis. Among them, glucocorticoids are steroid hormones secreted under the control of the hypothalamic-pituitary axis that have been well described to promote skeletal muscle atrophy but also to exert systemic actions through activation or repression of gene expression in many tissues. We hypothesized that the glucocorticoid pathway could be activated during cancer cachexia in ApcMin/+ mice, a mouse model of intestinal cancer. Here, we reported that activation of skeletal muscle catabolism was associated with a complete reprogramming of liver metabolism. Moreover, we showed an activation of the hypothalamus-pituitary axis that was associated with an increase in the level of corticosterone (the main glucocorticoid in rodent) in serum, quadriceps muscle and liver of advanced cancer cachectic mice. The transcriptional signature in quadriceps muscle and liver of advanced cancer cachectic mice significantly mirrored that observed in mice treated with dexamethasone, an analog glucocorticoid. Importantly, the inhibition of cancer cachexia by myostatin gene invalidation in ApcMin/+ mice restored corticosterone levels and abolished skeletal muscle and liver gene reprogramming. Together, these data indicate that glucocorticoids drive a transcriptional program to coordinately regulate skeletal muscle mass loss and hepatic metabolism rewiring. The inhibition of this response by myostatin gene invalidation highlights the existence of a molecular dialog between skeletal muscle and liver
Subramaniam, Sugarniya. "Expression, function, and regulation of two key genes involved in prostate cancer metabolism". Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/200151/1/Sugarniya_Subramaniam_Thesis.pdf.
Texto completoSaleem, Mohammed Umer. "Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs : synopsis - evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide". Thesis, University of Bradford, 2014. http://hdl.handle.net/10454/13842.
Texto completoPertile, Tatiane 1982. "Estudo do crescimento do carcinossarcoma de Walter 256 em ratos jovens e adultos, suplementados com ácido eicosapentaenóico (EPA)". [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314500.
Texto completoDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-19T11:32:15Z (GMT). No. of bitstreams: 1 Pertile_Tatiane_M.pdf: 1613871 bytes, checksum: 2d715c00e32e2a411050801a7a1ac95f (MD5) Previous issue date: 2011
Resumo: O câncer pode promover a morte do hospedeiro, pois durante sua evolução há modificações da homeostasia dos processos metabólicos, promovendo profundas alterações caracterizadas como caquexia, que por sua vez relaciona-se à diminuição da qualidade e do tempo de vida do hospedeiro. Assim, no presente estudo, analisamos os efeitos da evolução do crescimento de neoplasia - carcinossarcoma de Walker 256 - em ratos jovens e adultos e os efeitos modulatórios do tratamento desses animais com EPA (ácido eicosapentaenóico) sobre o processo de caquexia e a concentração de citocinas anti e proinflamatórias no músculo gastrocnêmio, pois o tecido muscular é o tecido mais afetado no processo de caquexia. Foram utilizados 108 ratos Wistar machos, com idade de 30 dias (jovens) e 100 dias (adultos), os quais foram distribuídos de acordo com o local de implante tumoral, intraperitônio e subcutâneo, e tratamento ou não com ácido eicosapentaenóico, 100?g/Kg de peso corpóreo. Os animais receberam gavagem diária do EPA (animais tratados) ou de óleo mineral (grupos sem tratamento) até a fase pré-agônica. A partir dos órgãos coletados, foram calculados o ganho de peso corpóreo, os pesos relativos de cada órgão, do tumor e da carcaça. Com o objetivo de identificarmos a via de degradação protéica predominante nos grupos experimentais, foram avaliados, no tecido muscular, o teor de proteína muscular total e as atividades das seguintes enzimas: chymotrypsin-like, catepsinas B e H, calpaína e fosfatase alcalina,. A partir do sangue desses animais foram feitas análises fluorimétricas do fator de crescimento semelhante à insulina (IGF) e das citocinas - interleucinas 4 (IL-4), 6 (IL-6) e 10 (IL-10), interferon gama (INF-?) e leptina, utilizando-se kits específicos para citômetro de fluxo de fluorescência (Luminex). Também foi analisada a expressão gênica, no tecido muscular, por reação em cadeia da polimerase em tempo real (PCR-RT), para a via proteossômica e também para os fatores eucarióticos de inicialização. Os dados indicam efeitos modulatórios do EPA sobre o tecido muscular (manutenção da proteína e do peso), principalmente para os grupos jovens, e também no processo inflamatório crônico (aumento de citocinas pró e antiinflamatórias). Entretanto, efeitos mais expressivos do EPA não foram verificados na prevenção da espoliação de gordura (gordura perirrenal e leptina), no processo de síntese protéica (manutenção da expressão gênica de fatores eucarióticos de inicialização) ou também sobre a via proteossômica
Abstract: Cancer can promotes the host death, because during its evolution there are modifications in metabolic processes of homeostasis, promoting deep changes characterized as cachexia, which in turn relates with reduction in quality and lifetime of the host. Thus, in this study, we analyze the effects of development in Walker 256 carcinoma evolution - in young and adults rats and the modulatory effect of treatment with EPA (eicosapentaenoic acid) in gastrocnemius muscle as this tissue is the most affected in the cachexia process. Wistar males rats were used (n=108 animals), 30 days-old (young) and 100 days-old (adults), which were distributed according to the tumour implant, intraperitoneally and subcutaneously and treatment or not with eicosapentaenoic acid, 100 ?g/Kg of body weight. The animals receive daily EPA by gavage (treated animals) or nujol (sham groups) and were cared up to pre-agonic state. The bodies weight were measured and the body weight gain was calculated, as well the relative weights of tissues, tumour, and carcass. In order to identify the predominant pathway of protein degradation the total muscle protein content and proteolytic enzymes activities (chymotrypsin-like, cathepsin B and H, calpain and alkaline phosphatase) were measured in gastrocnemius muscle. The blood samples were assessed to measure the insulin-like growth factor 1 (IGF-1), leptin and the cytokines - interleukins (IL-4), 6 (IL-6) and 10 (IL-10), gamma interferon (INF-?), using specific kits for cytometer fluorescence (Luminex). It was also examined gene expression, in the muscle tissue, by real-time polymerase chain reaction (RT-PCR), assessing keys of ubiquitin-proteasome pathway and also on the eukaryotic initiation factors. The data indicated some modulatory effects of EPA on the muscle tissue (maintenance of protein and weight), mainly for the young rats, and also the chronic inflammatory process. However, more expressive effects of EPA have not been verified as preventing fat wasting (perirenal fat and leptin), nor in the process of protein synthesis (maintenance of eukaryotic initiating factors gene expression) or also in the ubiquitin-proteasome via
Mestrado
Fisiologia
Mestre em Biologia Funcional e Molecular
Gang, Bevan. "Targeting cancer metabolism". Phd thesis, 2014. http://hdl.handle.net/1885/155803.
Texto completoKnowles, Andrew Llewellyn. "Small intestinal protein metabolism during cancer cachexia and chemotherapy in mice". Thesis, 1999. http://hdl.handle.net/2429/9088.
Texto completoLeung, Kevin Kai-Chi. "Dynamic Interleaved Imaging of Pyruvate Metabolism with Hyperpolarized 13C". Thesis, 2010. http://hdl.handle.net/1807/27311.
Texto completoLin, Yung-Ping y 林詠苹. "Ameliorating Effects and Cellular Metabolism of Oral Supplement with Blends of Porphyra-Monascus in a murine colon adenocarcinoma model for cancer cachexia". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/14287175086727768577.
Texto completo國立臺灣海洋大學
食品科學系
98
Abstract Cachexia, occurs in terminal cancer patients refers to a state of severe malnutrition characterized by anorexia, the loss of adipose tissue and skeletal muscle mass. Eicosapentaenoic acid (EPA) has been shown to attenuate the enhanced protein degradation. Furthermore, Red Yeast Rice also has been reported to inhibit tumor promotion. This study examines the synergic effects of Prophyra dentate (EPA rich) combined with Monascus purpureus supplementation in mice bearing the cachexia-inducing CT26 colon adenocarcinoma. P. dentate and M. purpureus (PM) diet were given by oral ad lib administration of feed chow to BALB/c mice, after multiple Cisplatin (CP) i.p. injection (3 mg/kg body weight) . Mice were divided into ten groups by different dosages, each group have ten mice and treatment lasted for 21 days. The mice were then sacrificed and analysis. In our result, Cisplatin created more serious cachexia symdrome. The PM diet at high dose can inhibit NF-B activated and IL-6 secrete so that can attenuate muscle wasting and weight loss. PM diet at five dose can also decrease liver and kidney’s toxicity by Cisplatin. In 28 days feeding subacute toxicity study, the 100 fold dosage PM diet didn’t have any toxicity with hamster. But it may had function of anti-obesity and regulation the blood lipid. Furthermore, Porphyra-Monascus fermentation powder extract is better than Monascus purpureus powder extract at anti-oxidation ability, anti-tumor ability and anti-inflammation ability. In conclusion, Animal models are useful in the study of cachexia. PM diet might have anti-cachexia/cancer propeties and it’s in safety. In addition, Porphyra-Monascus fermentation powder might have more useful propeties to attenuate cancer cachxia. Keywords: cancer cachexia, Monascus purpureus, Prophyra dentate