Literatura académica sobre el tema "Cag Type IV Secretion System"
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Artículos de revistas sobre el tema "Cag Type IV Secretion System"
Busler, Valerie J., Victor J. Torres, Mark S. McClain, Oscar Tirado, David B. Friedman y Timothy L. Cover. "Protein-Protein Interactions among Helicobacter pylori Cag Proteins". Journal of Bacteriology 188, n.º 13 (1 de julio de 2006): 4787–800. http://dx.doi.org/10.1128/jb.00066-06.
Texto completoPinto-Santini, Delia M. y Nina R. Salama. "Cag3 Is a Novel Essential Component of the Helicobacter pylori Cag Type IV Secretion System Outer Membrane Subcomplex". Journal of Bacteriology 191, n.º 23 (2 de octubre de 2009): 7343–52. http://dx.doi.org/10.1128/jb.00946-09.
Texto completoKumar, Navin, Mohd Shariq, Rajesh Kumari, Rakesh K. Tyagi y Gauranga Mukhopadhyay. "Cag Type IV Secretion System: CagI Independent Bacterial Surface Localization of CagA". PLoS ONE 8, n.º 9 (10 de septiembre de 2013): e74620. http://dx.doi.org/10.1371/journal.pone.0074620.
Texto completoCover, Timothy L., D. Borden Lacy y Melanie D. Ohi. "The Helicobacter pylori Cag Type IV Secretion System". Trends in Microbiology 28, n.º 8 (agosto de 2020): 682–95. http://dx.doi.org/10.1016/j.tim.2020.02.004.
Texto completoCouturier, Marc Roger, Elizabetta Tasca, Cesare Montecucco y Markus Stein. "Interaction with CagF Is Required for Translocation of CagA into the Host via the Helicobacter pylori Type IV Secretion System". Infection and Immunity 74, n.º 1 (enero de 2006): 273–81. http://dx.doi.org/10.1128/iai.74.1.273-281.2006.
Texto completoKutter, Stefan, Renate Buhrdorf, Jürgen Haas, Wulf Schneider-Brachert, Rainer Haas y Wolfgang Fischer. "Protein Subassemblies of the Helicobacter pylori Cag Type IV Secretion System Revealed by Localization and Interaction Studies". Journal of Bacteriology 190, n.º 6 (4 de enero de 2008): 2161–71. http://dx.doi.org/10.1128/jb.01341-07.
Texto completoTerradot, Laurent y Gabriel Waksman. "Architecture of the Helicobacter pylori Cag-type IV secretion system". FEBS Journal 278, n.º 8 (25 de febrero de 2011): 1213–22. http://dx.doi.org/10.1111/j.1742-4658.2011.08037.x.
Texto completoChung, Jeong Min, Michael J. Sheedlo, Anne M. Campbell, Neha Sawhney, Arwen E. Frick-Cheng, D. Borden Lacy, Timothy L. Cover y Melanie D. Ohi. "Structure of the Helicobacter pylori Cag Type IV Secretion System". Biophysical Journal 118, n.º 3 (febrero de 2020): 295a. http://dx.doi.org/10.1016/j.bpj.2019.11.1671.
Texto completoJurik, Angela, Elisabeth Haußer, Stefan Kutter, Isabelle Pattis, Sandra Praßl, Evelyn Weiss y Wolfgang Fischer. "The Coupling Protein Cagβ and Its Interaction Partner CagZ Are Required for Type IV Secretion of the Helicobacter pylori CagA Protein". Infection and Immunity 78, n.º 12 (27 de septiembre de 2010): 5244–51. http://dx.doi.org/10.1128/iai.00796-10.
Texto completoChang, Yi-Wei, Carrie L. Shaffer, Lee A. Rettberg, Debnath Ghosal y Grant J. Jensen. "In Vivo Structures of the Helicobacter pylori cag Type IV Secretion System". Cell Reports 23, n.º 3 (abril de 2018): 673–81. http://dx.doi.org/10.1016/j.celrep.2018.03.085.
Texto completoTesis sobre el tema "Cag Type IV Secretion System"
Pham, Kieu Thuy [Verfasser] y Wolfgang [Akademischer Betreuer] Fischer. "Functional characterization of the Helicobacter pylori Cag Type IV secretion system components CagH, CagI and CagL / Kieu Thuy Pham ; Betreuer: Wolfgang Fischer". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1124780033/34.
Texto completoJiménez, Soto Luisa Fernanda. "Studies on the function of the Cag Type IV Secretion System of Helicobacter pylori with integrin Beta1". kostenfrei, 2009. http://edoc.ub.uni-muenchen.de/10659/.
Texto completoJimenez, Soto Luisa Fernanda. "Studies on the function of the Cag Type IV Secretion System of Helicobacter pylori with integrin Beta1". Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-106597.
Texto completoZeitler, Anna Friederike [Verfasser] y Rainer [Akademischer Betreuer] Haas. "Identification of cellular mechanisms interfering with the Helicobacter pylori cag type IV secretion system / Anna Friederike Zeitler ; Betreuer: Rainer Haas". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1230754679/34.
Texto completoLopez-Lozano, Nina. "Caractérisation structurale de nanomachines bactériennes impliquées dans l'adaptabilité et la virulence". Electronic Thesis or Diss., Bordeaux, 2023. http://www.theses.fr/2023BORD0482.
Texto completoThis thesis is divided into two themes.The first theme focuses on the cag Type IV secretion system (cag-T4SS) of the bacterium Helicobacter pylori. This is a complex secretion machinery embedded in the bacterium's cellular envelope, enabling it to inject the CagA oncoprotein into human gastric epithelial cells. This toxin is considered a major virulence factor of H. pylori. It interacts with host proteins, disrupting cell signaling and leading to changes that can promote the development of gastrointestinal diseases, including gastric ulcers and cancers. The cag-T4SS is subdivided into three parts: (i) an inner membrane complex, composed essentially of ATPases providing the energy required for its assembly and/or its function; (ii) an outer membrane complex, or core complex, forming a channel that connects the inner and outer membranes; and (iii) an extracellular pilus, the existence of which is still controversial, and which would establish contact between the bacterium and its target, and possibly transfer substrates across the host membrane.The first project focuses on the extracellular pilus. The aim is to obtain data concerning a putative interaction between the CagI and CagL proteins, which are essential for secretion and are thought to be involved in the composition of the cag-T4SS pilus. We overexpressed recombinant versions of these proteins in Escherichia coli and co-purified them by affinity chromatography, demonstrating a direct interaction between them. The ability of DARPins and Nanobodies to bind this complex was tested. Analysis of these complexes was also undertaken by cryo-electron microscopy (cryoEM).The second project focuses on the core complex, with the aim of obtaining its structure at high resolution in order to shed light on the remaining grey areas concerning this imposing assembly. Various techniques have been used to solubilize this complex. Its purification remains to be optimized before it can be analyzed by cryoEM. Obtaining such structures could lead to a better understanding of how cag-T4SS functions, and to consider strategies to inhibit its assembly and/or function, thus depriving H. pylori of a major virulence factor.The second theme concerns bacterial spirosomes. The AdhE enzyme is highly conserved in the bacterial kingdom and in certain eukaryotic organisms. It is a bifunctional alcohol/aldehyde dehydrogenase enzyme, responsible for the conversion of acetyl-CoA to acetaldehyde and then to ethanol during anaerobic alcoholic fermentation. This enzyme is commonly found in its oligomeric form, known as spirosome. Depending on the ligands present in the medium, E. coli spirosomes can have a compact or extended conformation, the latter constituting the active form of the enzyme. Unlike E. coli spirosomes, Streptococcus pneumoniae ones are naturally stabilized in their extended conformation.The aim of this project is to understand the mechanisms behind this conformational difference. CryoEM enabled us to obtain a high-resolution structure of the S. pneumoniae spirosome and thus comparing it with the extended E. coli spirosome. Functional mutagenesis experiments with complementation enabled us to determine which residues are involved in the extension of these spirosomes. As they are involved in pathogenicity and have been shown to be essential to bacterial physiology in the absence of oxygen, in-depth study of their conformation could lead to the discovery of molecules capable of regulating their activity, which could be of major interest in the fields of biotechnology and healthcare
Bauer, Bianca. "Molekulare Charakterisierung von Typ IV Sekretionssytem-spezifischen Wirtszellantworten und bakteriellen Virulenzfaktoren des humanen Magenpathogens Helicobacter pylori". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16045.
Texto completoThe human gastric pathogen Helicobacter pylori (H. pylori) elicits a tremendous medical burden because of its causative association with peptic ulcer disease and gastric cancer. The pathogenic potential of H. pylori is intricately linked to the expression of a pathogenicity island encoded type IV secretion system (T4SS), which translocates the bacterial effector protein CagA into the eukaryotic host cell. The role of host cell determinants in T4SS mediated pathogenesis has not yet been systematically examined. To elucidate the role of host cell factors within T4SS induced host cell responses, different eukaryotic cell lines were analyzed systematically for respective phenotypes. Remarkably, T4SS mediated host responses among these cell lines varied considerably, thereby demonstrating the importance of host cell components in H. pylori induced pathogenesis. In addition, a H. pylori genome wide bacterial screen for factors important in pathogenesis, such as unknown T4SS components or novel NF-kappaB effector molecules, was developed and optimized. The precise function of the prominent effector protein CagA remains unclear. To functionally characterize the role of CagA, its impact on the epidermal growth factor (EGF)-receptor pathway was analyzed. The results suggest a mechanism where EGF-receptor endocytosis is completely blocked by a CagA induced activation of c-Abl, leading to an elevated receptor surface exposition. Surprisingly, EGF-receptor transactivation and EGF-dependent wound healing are selectively blocked during prolonged infections as well, indicating that an increased receptor-population on the cell surface does not necessarily promote signaling. This data suggests a role for the EGF-receptor in H. pylori- induced ulcer disease. The underlying molecular mechanism was identified as being SHP-2 and CagA dependent.
Connery, Sarah. "Reconstitution and localisation studies of a type IV secretion system". Thesis, Birkbeck (University of London), 2014. http://bbktheses.da.ulcc.ac.uk/75/.
Texto completoSutten, Eric Lynn. "The immunogenicity of the type IV secretion system in Anaplasma marginale". Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Summer2009/e_sutten_072409.pdf.
Texto completoTitle from PDF title page (viewed on Aug. 7, 2009). "Department of Veterinary Microbiology and Pathology." Includes bibliographical references.
Schindele, Franziska Maria [Verfasser] y Rainer [Akademischer Betreuer] Haas. "Development and application of a novel Cag type IV secretion reporter assay in Helicobacter pylori / Franziska Maria Schindele ; Betreuer: Rainer Haas". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1156173116/34.
Texto completoEngledow, Amanda Suzanne. "Role of type IV secretion systems in trafficking of virulence determinants of Burkholderia cenocepacia". Thesis, [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1841.
Texto completoCapítulos de libros sobre el tema "Cag Type IV Secretion System"
Backert, Steffen, Rainer Haas, Markus Gerhard y Michael Naumann. "The Helicobacter pylori Type IV Secretion System Encoded by the cag Pathogenicity Island: Architecture, Function, and Signaling". En Current Topics in Microbiology and Immunology, 187–220. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-75241-9_8.
Texto completoCallaghan, Melanie M., Jan-Hendrik Heilers, Chris van der Does y Joseph P. Dillard. "Secretion of Chromosomal DNA by the Neisseria gonorrhoeae Type IV Secretion System". En Current Topics in Microbiology and Immunology, 323–45. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-75241-9_13.
Texto completoVincent, Carr D., Kwang Cheol Jeong, Jessica Sexton, Emily Buford y Joseph P. Vogel. "The Legionella pneumophila Dot/Icm Type IV Secretion System". En Legionella, 184–91. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555815660.ch47.
Texto completoQiu, Jiazhang y Zhao-Qing Luo. "Effector Translocation by the Legionella Dot/Icm Type IV Secretion System". En Current Topics in Microbiology and Immunology, 103–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/82_2013_345.
Texto completoVincent, Carr D., Jonathan R. Friedman y Joseph P. Vogel. "Defining the Translocation Pathway of the Legionella pneumophila Type IV Secretion System". En Legionella, 195–98. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555815660.ch49.
Texto completoKubori, Tomoko y Hiroki Nagai. "Isolation of the Dot/Icm Type IV Secretion System Core Complex from Legionella pneumophila". En Methods in Molecular Biology, 241–47. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9048-1_15.
Texto completoRikihisa, Yasuko. "Role and Function of the Type IV Secretion System in Anaplasma and Ehrlichia Species". En Current Topics in Microbiology and Immunology, 297–321. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-75241-9_12.
Texto completoHilbi, Hubert, Hiroki Nagai, Tomoko Kubori y Craig R. Roy. "Subversion of Host Membrane Dynamics by the Legionella Dot/Icm Type IV Secretion System". En Current Topics in Microbiology and Immunology, 221–42. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-75241-9_9.
Texto completoZhu, Wenhan y Zhao-Qing Luo. "Methods for Determining Protein Translocation by the Legionella pneumophila Dot/Icm Type IV Secretion System". En Methods in Molecular Biology, 323–32. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-161-5_19.
Texto completoSo, Ernest C., Aurélie Mousnier, Gad Frankel y Gunnar N. Schroeder. "Determination of In Vivo Interactomes of Dot/Icm Type IV Secretion System Effectors by Tandem Affinity Purification". En Methods in Molecular Biology, 289–303. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9048-1_19.
Texto completoActas de conferencias sobre el tema "Cag Type IV Secretion System"
Esna Ashari, Zhila, Kelly A. Brayton y Shira L. Broschat. "Determining Optimal Features for Predicting Type IV Secretion System Effector Proteins for Coxiella burnetii". En BCB '17: 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3107411.3107416.
Texto completoSaito, Atsushi, Shigeru Ariki, Hiroki Takahashi y Yoshio Kuroki. "Pulmonary collectins provide a first line of defense against L. Pneumophila through inhibiting their type IV secretion system". En ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa4121.
Texto completoTandon, N. N. y G. A. Jamieson. "ROLE OF PLATELET MEMBRANE GLYCOPROTEIN IV IN PLATELET-COLLAGEN INTERACTION: A MICROTITER ASSAY TO STUDY PLATELET ADHERENCE". En XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643906.
Texto completoInformes sobre el tema "Cag Type IV Secretion System"
Elbaum, Michael y Peter J. Christie. Type IV Secretion System of Agrobacterium tumefaciens: Components and Structures. United States Department of Agriculture, marzo de 2013. http://dx.doi.org/10.32747/2013.7699848.bard.
Texto completoSplitter, Gary A., Menachem Banai y Jerome S. Harms. Brucella second messenger coordinates stages of infection. United States Department of Agriculture, enero de 2011. http://dx.doi.org/10.32747/2011.7699864.bard.
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