Literatura académica sobre el tema "Blood-brain barrier"
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Artículos de revistas sobre el tema "Blood-brain barrier"
KANDA, Takashi. "Blood-Brain Barrier and Blood-Nerve Barrier". Yamaguchi Medical Journal 54, n.º 1 (2005): 5–11. http://dx.doi.org/10.2342/ymj.54.5.
Texto completoShalaby, Mohamed Adel. "Blood-Brain Barrier". Al-Azhar Medical Journal 45, n.º 3 (julio de 2016): i—vi. http://dx.doi.org/10.12816/0033115.
Texto completoLawther, Bradley K., Sajith Kumar y Hari Krovvidi. "Blood–brain barrier". Continuing Education in Anaesthesia Critical Care & Pain 11, n.º 4 (agosto de 2011): 128–32. http://dx.doi.org/10.1093/bjaceaccp/mkr018.
Texto completoDunn, Jeff F. y Albert M. Isaacs. "The impact of hypoxia on blood-brain, blood-CSF, and CSF-brain barriers". Journal of Applied Physiology 131, n.º 3 (1 de septiembre de 2021): 977–85. http://dx.doi.org/10.1152/japplphysiol.00108.2020.
Texto completoKoziara, J. M., P. R. Lockman, D. D. Allen y R. J. Mumper. "The Blood-Brain Barrier and Brain Drug Delivery". Journal of Nanoscience and Nanotechnology 6, n.º 9 (1 de septiembre de 2006): 2712–35. http://dx.doi.org/10.1166/jnn.2006.441.
Texto completoCho, Choi-Fong. "The Blood-Brain Barrier". Oncology Times 40, n.º 2 (enero de 2018): 1. http://dx.doi.org/10.1097/01.cot.0000530114.97923.aa.
Texto completoMizee, Mark Ronald y Helga Eveline de Vries. "Blood-brain barrier regulation". Tissue Barriers 1, n.º 5 (diciembre de 2013): e26882. http://dx.doi.org/10.4161/tisb.26882.
Texto completoDobbing, John. "The Blood-Brain Barrier". Developmental Medicine & Child Neurology 3, n.º 6 (12 de noviembre de 2008): 610–12. http://dx.doi.org/10.1111/j.1469-8749.1961.tb10430.x.
Texto completoDobbing, John. "The Blood-Brain Barrier". Developmental Medicine & Child Neurology 3, n.º 4 (12 de noviembre de 2008): 311–14. http://dx.doi.org/10.1111/j.1469-8749.1961.tb15323.x.
Texto completoDaneman, Richard y Alexandre Prat. "The Blood–Brain Barrier". Cold Spring Harbor Perspectives in Biology 7, n.º 1 (enero de 2015): a020412. http://dx.doi.org/10.1101/cshperspect.a020412.
Texto completoTesis sobre el tema "Blood-brain barrier"
Podjaski, Cornelia. "Netrins enhance blood-brain barrier function and regulate immune responses at the blood-brain barrier". Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116977.
Texto completoAu cours du développement, les molécules de la famille des nétrines contribuent à la morphologénèse des organes en contrôlant la motilité et l'adhérence cellulaire. L'adhérence cellulaire entre les cellules endothéliales est une caractéristique importante de la barrière hémato-encéphalique (BHE), ce qui rend l'endothélium imperméable aux molécules sanguines et aux cellules immunitaires. Pour établir et maintenir cette barrière au cours du développement, à l'âge adulte et au cours de la maladie, les cellules endothéliales du cerveau doivent développer et maintenir ces contacts adhésifs en exprimant des molécules de jonction serrées. Cependant, nous ne savons pas si les molécules de la famille des nétrines influencent l'adhérence cellulaire inter-endothéliale de la BHE. Nous avons donc émis l'hypothèse que les nétrines resserrent la BHE au cours du développement, à l'âge adulte, et la protège au cours de la maladie.Méthodes: Pour valider notre hypothèse, nous avons utilisé des cellules endothéliales primaires dérivées des cerveaux humains adultes ou des cerveaux de souris nouveau-nés déficientes en nétrine-1 et évalué l'effet de la nétrine sur l'adhésion cellulaire endothéliale et inter-perméabilité de la barrière. Nous avons également évalué le potentiel thérapeutique des nétrines a restaurer la barrière et l'infiltration de cellules immunitaires limite dans le système nerveux central (SNC) pendant encéphalomyélite allergique expérimentale, un modèle animal de sclérose en plaques. Résultats: Nos résultats démontrent que les nétrines sont exprimées par les cellules endothéliales du cerveau, exprimes nétrines. Au cours du développement les nétrines aident à assurer l'étanchéité de la BHE. Chez les adultes, ils maintiennent et protègent la barrière adulte en augmentant l'expression des molécules de jonctions serrées, favorisant ainsi l'adhérence inter-endothéliale et diminuant les fuites de protéines à travers la BHE. Dans la pathologie de l'EAE, le rôle des nétrins diffère en fonction de la phase de la maladie. Au cours de la phase aigue, les nétrines atténuent la perte de l'intégrité de la BHE et diminuent l'infiltration des cellules myéloïdes dans le SNC. Ceci retarde l'apparition de la maladie et réduit sa sévérité. Au cours de la phase chronique de l'EAE, les souris traitées avec netrin-1 ont un plus grand nombre des cellules T activées dans leurs SNC et présentent une démarche ataxique ainsi qu'une spasticité des membres. Discussion: Nous concluons que les nétrins améliorent la stabilité de la BHE. Ces résultats suggèrent que les nétrines peuvent être envisagée comme agent thérapeutique dans les maladies neuroinflammatoire. Dans ce cas une approche précoce et à court terme serait probablement plus efficace.
Zhu, Chunni. "The Blood-brain barrier in normal and pathological conditions". Title page, abstract and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phz637.pdf.
Texto completoBrownlees, Janet. "Some enzymes of the blood-brain barrier". Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334522.
Texto completoRaabe, Rebecca L. "Radiation effects on the blood-brain barrier". Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/44779.
Texto completoIncludes bibliographical references (p. 53-56).
Selective vascular irradiation enables the critical examination of the vasculature and its role in the onset of late radiation effects. It is a novel approach to expose the endothelial cells to much higher levels of ionizing radiation relative to normal cells by utilizing the boron neutron capture reaction. When boron-containing compounds are restricted to the lumen of the blood vessel, the resulting high-LET alpha and lithium particles cannot deposit their energy in the normal cells beyond the vasculature after the target is exposed to thermal neutrons. This allows for a 2- to 3-fold increase in the calculated dose to the endothelial cells. However, this technique has been criticized because there is no direct evidence that the endothelial cells receive an absorbed dose from the selective vascular irradiation. The objective of this work is to provide corroborating experimental evidence that selective vascular irradiation physically damages the endothelial cells. An established assay utilizing blood-brain barrier disruption was adopted to quantify the radiation damage to the endothelial cells in female BALB/C mice, 8-12 weeks of age. A dye that attaches to the plasma proteins in the blood and that is ordinarily kept out of the brain by the blood-brain barrier is injected into the blood supply before the irradiation, and following irradiation, damage to the vasculature will result in disruption of the blood-brain barrier that allows blood stained with the dye to enter the brain. After sacrificing, the blood in the vessel lumen is cleared by performing a trans-cardiac perfusion, and the brain is homogenized and prepared for analysis. The absorbance of the resulting supernatant of each brain sample is measured with a spectrophotometer at the optimal wavelength of the dye.
(cont.) The absorbance is related to the quantity of blood that leaked through the blood-brain barrier, which is also related to the damage caused to the vasculature from exposure to ionizing radiation. Increased leakage through the blood-brain barrier was observed for those mice exposed to selective vascular irradiation, indicating a direct relationship between the leakage through the blood-brain barrier and the 10B concentration in the blood. The most significant increase in the leakage through the blood-brain barrier (p<0.002) was observed at the highest lOB concentration in the blood (161 ppm). The compound biological effectiveness (CBE) for sulfhydryl borane (BSH) was calculated to be 0.28, which is consistent with the published value of the CBE for BSH in the rat spinal cord. This suggests that the assumptions used for calculating the absorbed doses for selective vascular irradiation are reasonable and approximate to what the endothelial cells receive.
by Rebecca L. Raabe.
S.M.
Lochhead, Jeffrey James. "Oxidative Stress Alters Blood-Brain Barrier Integrity". Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/193873.
Texto completoArranz, Gibert Pol. "Blood-Brain Barrier Shuttles: From Design to Application". Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/401325.
Texto completoLa barrera hematoencefàlica (BHE) actua com a protecció del sistema nerviós central (SNC) regulant el transport de molècules d’una manera selectiva. Això dificulta el tractament de malalties que afecten al SNC, ja que la BHE també evita que fàrmacs que serien efectius no siguin transportats al cervell. Per això, s’estan desenvolupant mètodes que permetin enviar selectivament fàrmacs a través de la BHE. És el cas dels pèptids llançadora. Aquests es poden dissenyar per creuar per algun dels mecanismes de transport existents en la BHE. En aquesta tesi es desenvolupen uns pèptids que creuen per difusió passiva (basats en fenilprolines), que respecte al disseny anterior (basats en N‐ metilfenilalanines) milloren la solubilitat en aigua en tres ordres de magnitud i al transport un cop s’hi enganxa el fàrmac. Per una altra banda, es desenvolupa una metodologia per a la quantificació del transport basada en la combinació d’espectrometria de masses MALDI‐TOF amb models de BHE in vitro (cel∙lulars), millorant la sensibilitat respecte a la detecció per RP‐HPLC‐PDA en tres ordres de magnitud. L’avaluació d’una peptidoteca derivada d’un pèptid llançadora mitjançant aquesta metodologia permet el descobriment de dos anàlegs del pèptid original que milloren el transport. Addicionalment, s’estudia la immunogenicitat de pèptids llançadora formats per aminoàcids L o D. S’observa que encara que ambdós mostren una baixa immunogenicitat, la resposta dels pèptids amb aminoàcids D és encara menor. Finalment, s’estudia de forma preliminar la possibilitat de desenvolupar una teràpia de reemplaçament proteic i una teràpia gènica per atàxia de Friedreich al SNC mitjançant l’ús de pèptids llançadora.
Chen, Bo. "Role of blood-brain barrier leakage during stroke". Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3403853.
Texto completoEdrissi, Hamidreza. "Blood Brain Barrier Dysfunction in Chronic Cerebral Ischemia". Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32531.
Texto completoOwe-Young, Robert School of Medicine UNSW. "Kynurenine pathway metabolism at the blood-brain barrier". Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/26183.
Texto completoBénardais, Karelle [Verfasser]. "Modulation of the blood-brain barrier / Karelle Bénardais". Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1037791665/34.
Texto completoLibros sobre el tema "Blood-brain barrier"
Nag, Sukriti. Blood-Brain Barrier,. New Jersey: Humana Press, 2003. http://dx.doi.org/10.1385/1592594190.
Texto completoKobiler, David, Shlomo Lustig y Shlomo Shapira, eds. Blood—Brain Barrier. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-0579-2.
Texto completoBarichello, Tatiana, ed. Blood-Brain Barrier. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-8946-1.
Texto completoR, Helio Tomas, ed. The blood brain barrier. New York: Nova Science Publishers, 2008.
Buscar texto completoStone, Nicole, ed. The Blood-Brain Barrier. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2289-6.
Texto completoJ, Suckling Anthony, Rumsby M. G y Bradbury M. W. B, eds. The Blood-brain barrier in health and disease. Chichester [Essex], England: E. Horwood, 1986.
Buscar texto completoMontenegro, Pedro A. The blood-brain barrier: New research. Hauppauge, N.Y: Nova Science Publishers, 2011.
Buscar texto completoFricker, Gert, Melanie Ott y Anne Mahringer, eds. The Blood Brain Barrier (BBB). Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-43787-2.
Texto completoA, Neuwelt Edward, ed. Implicationsof the blood-brain barrier and its manipulation. New York: Plenum Medical, 1989.
Buscar texto completoPierre-Olivier, Couraud, Scherman Daniel y Cerebral Vascular Biology Symposium (1995 : Paris, France), eds. Biology and physiology of the blood-brain barrier: Transport, cellular interactions, and brain pathologies. New York: Plenum Press, 1996.
Buscar texto completoCapítulos de libros sobre el tema "Blood-brain barrier"
Tran, Nam. "Blood-Brain Barrier". En Encyclopedia of Clinical Neuropsychology, 601–2. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_299.
Texto completoTyrer, Peter J., Mark Slifstein, Joris C. Verster, Kim Fromme, Amee B. Patel, Britta Hahn, Christer Allgulander et al. "Blood–Brain Barrier". En Encyclopedia of Psychopharmacology, 241–45. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_387.
Texto completoTran, Nam. "Blood-Brain Barrier". En Encyclopedia of Clinical Neuropsychology, 1–2. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56782-2_299-2.
Texto completoScherrmann, Jean-Michel. "Blood–Brain Barrier". En Encyclopedia of Psychopharmacology, 302–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-36172-2_387.
Texto completoAvraham, Shalom, Tzong-Shi Lu y Hava Karsenty Avraham. "Blood-Brain Barrier". En Encyclopedia of Cancer, 1–5. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27841-9_669-2.
Texto completoAlemanno, Fernando. "Blood–Brain Barrier". En Biochemistry for Anesthesiologists and Intensivists, 71–74. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-26721-6_7.
Texto completoLeshan, Rebecca, Teri Milner y Donald W. Pfaff. "Blood-Brain Barrier". En Neuroscience in the 21st Century, 1911–20. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3474-4_129.
Texto completoLeshan, Rebecca, Teri Milner y Donald W. Pfaff. "Blood-Brain Barrier". En Neuroscience in the 21st Century, 1–10. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-6434-1_129-3.
Texto completoLeshan, Rebecca, Teresa A. Milner y Donald W. Pfaff. "Blood-Brain Barrier". En Neuroscience in the 21st Century, 1–10. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4614-6434-1_129-4.
Texto completoAvraham, Shalom, Tzong-Shi Lu y Hava Karsenty Avraham. "Blood-Brain Barrier". En Encyclopedia of Cancer, 556–59. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-46875-3_669.
Texto completoActas de conferencias sobre el tema "Blood-brain barrier"
Saharov, D. "CREATION OF IN VITRO MODEL OF HUMAN BLOOD-BRAIN BARRIER, COMPLETELY IDENTIFICAL TO REAL BLOOD-BRAIN BARRIER". En 19th SGEM International Multidisciplinary Scientific GeoConference EXPO Proceedings. STEF92 Technology, 2019. http://dx.doi.org/10.5593/sgem2019/6.1/s24.019.
Texto completoChaing, Ya-Yu y Kai-Hong Tu. "In Vitro Microfluidics-based Blood–brain Barrier Model". En 2019 IEEE 14th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE, 2019. http://dx.doi.org/10.1109/nems.2019.8915667.
Texto completoChen, Dechang, Jianwen Fang y Jiawei Yu. "Predicting Blood-Brain Barrier Penetration by Stochastic Discrimination". En 2008 International Conference on Biomedical Engineering And Informatics (BMEI). IEEE, 2008. http://dx.doi.org/10.1109/bmei.2008.243.
Texto completoGuanglei Li, Wei Yuan y Bingmei M. Fu. "A transport model for the blood-brain barrier". En 2007 IEEE 33rd Annual Northeast Bioengineering Conference. IEEE, 2007. http://dx.doi.org/10.1109/nebc.2007.4413342.
Texto completoLi, Guanglei, Melissa J. Simon, Limary Cancel, Zhong-Dong Shi, Xinyi Ji, John M. Tarbell, Barclay Morrison y Bingmei M. Fu. "Permeability of in vitro blood-brain barrier models". En 2010 36th Annual Northeast Bioengineering Conference. IEEE, 2010. http://dx.doi.org/10.1109/nebc.2010.5458260.
Texto completoChoi, James J. "Noninvasive Blood-Brain Barrier Opening in Live Mice". En THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound. AIP, 2006. http://dx.doi.org/10.1063/1.2205480.
Texto completoHynynen, Kullervo. "Notice of Removal: Breaching the blood-brain barrier noninvasively". En 2017 IEEE International Ultrasonics Symposium (IUS). IEEE, 2017. http://dx.doi.org/10.1109/ultsym.2017.8092834.
Texto completoSaharov, D. A. "DEVELOPMENT OF CELLULAR MODEL OF HUMAN BLOOD-BRAIN BARRIER". En 19th SGEM International Multidisciplinary Scientific GeoConference EXPO Proceedings. STEF92 Technology, 2019. http://dx.doi.org/10.5593/sgem2019/6.1/s25.085.
Texto completoKline-Schoder, Alina R., Sana Chintamen, Vilas Menon, Steven G. Kernie y Elisa E. Konofagou. "Focused-ultrasound blood-brain barrier opening promotes neuroprotective microglia". En 2022 IEEE International Ultrasonics Symposium (IUS). IEEE, 2022. http://dx.doi.org/10.1109/ius54386.2022.9958101.
Texto completoDavalos, Dimitrios. "Microglial Responses to Blood Brain Barrier Disruption in Neuroinflammatory Disease". En Optics and the Brain. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/brain.2016.bth3d.5.
Texto completoInformes sobre el tema "Blood-brain barrier"
Aschner, Michael. Blood-Brain Barrier Transport of Uranium. Fort Belvoir, VA: Defense Technical Information Center, septiembre de 2004. http://dx.doi.org/10.21236/ada433990.
Texto completoAschner, Michael. Blood-Brain Barrier Transport of Uranium. Fort Belvoir, VA: Defense Technical Information Center, septiembre de 2002. http://dx.doi.org/10.21236/ada412998.
Texto completoAschner, Michael. Blood-Brain Barrier Transport of Uranium. Fort Belvoir, VA: Defense Technical Information Center, septiembre de 2003. http://dx.doi.org/10.21236/ada422003.
Texto completoGoldman, Harold y Robert F. Berman. Regional Blood-Brain Barrier Responses to Central Cholinergic Activity. Fort Belvoir, VA: Defense Technical Information Center, junio de 1991. http://dx.doi.org/10.21236/ada246911.
Texto completoZhang, Luwen. Epstein Barr Virus and Blood Brain Barrier in Multiple Sclerosis. Fort Belvoir, VA: Defense Technical Information Center, julio de 2013. http://dx.doi.org/10.21236/ada593294.
Texto completoZhang, Luwen. Epstein Barr Virus and Blood Brain Barrier in Multiple Sclerosis. Fort Belvoir, VA: Defense Technical Information Center, enero de 2014. http://dx.doi.org/10.21236/ada596844.
Texto completoGoldstein, L. B., A. M. Dechovskaia, S. Bullman, K. H. Jones y A. A. Abdel-Rahman. Daily Dermal Co-Exposure of Rats to DEET and Permethrin Produces Sensorimotor Deficit, and Changes in Blood-Brain Barrier (BBB) and Blood-Testis Barrier (BTB). Fort Belvoir, VA: Defense Technical Information Center, marzo de 2001. http://dx.doi.org/10.21236/ada402081.
Texto completoAvraham, Hava. Oxidative Stress Increases the Blood Brain Barrier Permeability Resulting in Increased Incidence of Brain Metastasis in BRCA Mutation Carriers. Fort Belvoir, VA: Defense Technical Information Center, febrero de 2013. http://dx.doi.org/10.21236/ada576308.
Texto completoAvraham, Hava. Oxidative Stress Increases the Blood Brain Barrier Permeability Resulting in Increased Incidence of Brain Metastasis in BRCA Mutation Carriers. Fort Belvoir, VA: Defense Technical Information Center, febrero de 2012. http://dx.doi.org/10.21236/ada560888.
Texto completoChoi, Hannah. The Review of Central Nervous System Drug Delivery Through the Blood Brain Barrier using Nanoparticles for Treatment of Brain Diseases. Ames (Iowa): Iowa State University, mayo de 2023. http://dx.doi.org/10.31274/cc-20240624-1482.
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