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Tesis sobre el tema "Biochemical Science"

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Publicado: 6 de septiembre de 2023

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1

Drawert, Brian J. "Spatial Stochastic Simulation of Biochemical Systems." Thesis, University of California, Santa Barbara, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3559784.

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<p> Recent advances in biology have shown that proteins and genes often interact probabilistically. The resulting effects that arise from these stochastic dynamics differ significantly than traditional deterministic formulations, and have biologically significant ramifications. This has led to the development of computational models of the discrete stochastic biochemical pathways found in living organisms. These include spatial stochastic models, where the physical extent of the domain plays an important role; analogous to traditional partial differential equations. </p><p> Simulation of spa
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2

Barb, Jessica Gaus. "Biochemical, Genetic, and Cytogenetic Studies of Stokesia laevis (Stokes Aster)." NCSU, 2007. http://www.lib.ncsu.edu/theses/available/etd-11302007-145604/.

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Stokesia laevis (J. Hill) Greene is a herbaceous perennial with blue, lavender, violet, albescent, pale yellow or pale pink flowers. All cultivars are diploid (2n=2x=14) except for ?Omega Skyrocket, a tetraploid (2n=4x=28) cultivar selected from a wild population. Anthocyanidin and copigment aglycones extracted from floral tissue were characterized using high-performance liquid chromatography. Results indicated that blue, lavender, violet and albescent flowers contained petunidin, though albescent flowers contained a substantially smaller amount. Pale pink flowers were found to contain only cy
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3

Edwards, Lorraine Katy. "Biochemical characterization of mammalian high mobility group protein A2." FIU Digital Commons, 2006. http://digitalcommons.fiu.edu/etd/3118.

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The high mobility group protein HMGA2 is an architectural transcription factor, which is expressed during embryogenesis. Aberrant expression causes benign and malignant tumor formation. The protein possesses three "AT hook" domains and an acidic Cterminal. HMGA2 is natively unstructured, however it forms a homodimer. In this study site-directed mutagenesis was used to create single methionine mutants, HMGA2Q37M, HMGA2I71M and HMGA2Q85M. These mutants were cross-linked using EDC and then cleaved using CNBr to determine which domains are involved in homodimer formation. Our results indicate that
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4

Mistry, Dharmit. "Mechanistic studies of some chemical and biochemical reactions." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/23444/.

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Three aspects of chemical and biochemical reactions were investigated. 1. The relative reactivities of pyrophosphate (phosphorus(V)) and pyro-di-H-phosphonate (phosphorus(III)) and its derivatives have been analysed at various pHs. The hydrolysis rate of pyro-di-H-phosphonate (PP(III)) was found to be higher than pyrophosphate at all pHs. Using ITC and NMR, pyrophosphate showed metal-ion complexing abilities whereas pyro-di-H-phosphonate showed weak or no complexing to metal-ions, although the rate of hydrolysis at pH 7 slightly increased compared to the spontaneous hydrolysis of PP(III). The
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5

Hart, Jaynee E. "Biochemical and genetic approaches to modulate phototropin photoreceptor sensitivity." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30991/.

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The necessity of light for plants to sustain their autotrophic lifestyle has made the optimization of growth to maximize light capture a crucial strategy for survival in light-limiting environments. Increases in light capture can be achieved through alterations in plant architecture, such as modifications to leaf position and stem length. Responses to the light environment are mediated by a network of photoreceptor proteins, which sense specific wavelengths of light and respond to light excitation by initiating signaling. Higher plants respond to red and far-red light through the phytochrome f
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6

Khartabil, Rana. "User-centered design and evaluation of a dynamic biochemical pathway visualization tool." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/26944.

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Information visualization is a field of computer science that deals with the computerized visualization of complex information in a form that is easier for human beings to comprehend. Information visualization has applications in many domains, including business, science, and medicine. Visualization of biochemical pathways, as graphs of nodes representing biochemical entities and arcs representing the relationships between entities, is one such application. This thesis begins by reviewing work that has been done on the usability of information visualization techniques, and in particular these
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7

Woo, Sung Sik Ph D. Massachusetts Institute of Technology. "Fast simulation of stochastic biochemical reaction networks on cytomorphic chips." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/107292.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 169-181).<br>The large-scale simulation of biochemical reaction networks in cells is important in pathway discovery in medicine, in analyzing complex cell function in systems biology, and in the design of synthetic biological
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8

Pérez, Verona Isabel Cristina. "Approaches for the exact reduction of large-scale biochemical models." Thesis, IMT Alti Studi Lucca, 2020. http://e-theses.imtlucca.it/303/1/P%C3%A9rezVerona_phdthesis.pdf.

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Mathematical models are a fundamental tool used in many branches of science and engineering to gain insights into the dynamics of systems. In Systems Biology [122], these models facilitate the analysis of complex biochemical networks that describe molecular interactions at different level in living organisms. In the last years, several efforts have been dedicated to the characterization of biological systems [98, 127, 128, 165, 209], specific interaction mechanisms [10, 15, 44, 45] and biological phenomena such as oscillations and bistability [80, 119, 147, 175]. As result, the use of
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9

Santra, Tapesh. "Evolutionarily stable and fragile modules of yeast biochemical network." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2644/.

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Gene and protein interaction networks have evolved to precisely specify cell fates and functions. Here, we analyse whether the architecture of these networks affects evolvability. We find evidence to suggest that in yeast these networks are mainly acyclic, and that evolutionary changes in these parts do not affect their global dynamic properties. In contrast, feedback loops strongly influence dynamic behaviour and are often evolutionarily conserved. Feedback loops are often found to reside in a clustered manner by means of coupling and nesting with each other in the molecular interaction netwo
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10

Royle, Christopher. "Physiological and biochemical responses to frequent milking in dairy cows." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385209.

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11

Irvine, Darrell J. (Darrell John) 1973. "Spatially controlled presentation of biochemical ligands on biomaterial surfaces using comb polymers." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/109636.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2000.<br>Vita.<br>Includes bibliographical references (p. 243-257).<br>by Darrell J. Irvine.<br>Ph.D.
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12

Widdowson, Philip. "Biochemical and biophysical characterisation of Anopheles gambiae NADPH-cytochrome P450 reductase." Thesis, University of Liverpool, 2010. http://livrepository.liverpool.ac.uk/1496/.

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As the principal vector for the transmission of the Plasmodium falciparum parasite, and hence the spread of malaria in Sub-Saharan Africa, Anopheles gambiae is a globally significant species of mosquito. Over recent years, the efficacy of established insecticides has waned and there is a constant need for novel effective compounds. Cytochrome P450 reductase (CPR) is a diflavoprotein known to have a central role in phase I metabolism of xenobiotic compounds and, in mosquitoes, this involves the detoxification of insecticides. Due to an inherent lack of understanding regarding the mechanisms of
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13

Hocking, Damien. "Object-oriented simulation of chemical and biochemical processes /." Title page and contents only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phh6847.pdf.

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14

Klejnot, Marta. "Structural and biochemical insights into members of the kinesin and ubiquitin ligase families." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/5108/.

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The thesis focuses on characterisation of two different protein families, kinesins and ubiquitin ligases, that are involved in different biological processes. Kinesins constitute a superfamily of microtubule-based motor proteins, fulfilling important cellular functions, ranging from intracellular transport to cell division. They also play a role in primary cilia and Hedgehog signalling. Ubiquitin ligases are enzymes that catalyse the transfer of ubiquitin to the lysine residues of the substrate. Marking protein substrates with ubiquitin alters their functions and fates. With nearly 700 differe
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15

Mayer, Matthias. "A structural and biochemical comparison of wild-type and recombinant propanediol utilising bacterial microcompartments." Thesis, University of Kent, 2016. https://kar.kent.ac.uk/54756/.

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Bacterial microcompartments (BMCs) likely represent the largest protein complex found in bacterial cells (estimated 18,000 subunits). BMCs are associated with specific metabolic processes such as carbon fixation in the case of carboxysomes or carbon utilisation in the case of the 1,2-propanediol utilisation metabolosome. With all BMCs there is still much to learn about the structure and function of these supramolecular assemblies. In this project the structure and function of the Pdu BMC has been studied through a combination of recombinant DNA technology, proteomics, fluorescence microscopy,
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16

Laine, Marjo L. "Functional, biochemical and structural analyses of Plasmodium falciparum pyruvate dehydrogenase complex." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5043/.

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The apicomplexan parasite Plasmodium is the causative agent of the devastating tropical disease, malaria. The World Health Organisation reported that in 2010 there were an estimated 219 million malaria cases and about 660,000 deaths. Sub-Saharan Africa is the worst affected, with 80% of malaria deaths and 90% of cases occurring in this area of the world. P. falciparum causes the most severe form of the illness and accounts for the majority of malaria deaths. Parasite resistance to antimalarials including the most effective drug, artemisinin, is becoming an increasing problem, thus research int
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17

Bray, James William. "Quantification of training load, neuromuscular fatigue, biochemical and endocrine responses to fast bowling in cricket." Thesis, University of Hull, 2017. http://hydra.hull.ac.uk/resources/hull:16447.

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Recent professionalization, the emergence of, and ever-increasing popularity of limited overs cricket, have resulted in traditional playing schedules evolving and expanding. Consequently, players now compete for much of the year, experiencing periods of condensed fixtures. To meet these increased demands, the aforementioned contribute to effecting team performance and player health. Thus, the prevalence of injuries, especially amongst fast bowlers, has been shown and attributed to rises in competition workloads. Therefore, the main aim of this thesis was to explore the application of micro-ele
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18

Liu, Weizhi. "Microcapsule internalization by cells in vitro caused by physical and biochemical stimuli." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8551.

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There is a growing interest in micro sized vehicles with the function of storing, targeting and controlled releasing of substances during the past few decades. However, delivering the desired drugs inside micro containers to living cells is a particular challenging topic of material science. Microcapsules made of polyelectrolyte multilayers exhibit low- or non-toxicity, appropriate mechanical stability, variable degradation and can incorporate remotely addressable release mechanisms in responding to stimuli and external triggering, making them well suitable for targeted drug delivery to live c
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19

SINGH, SHERJANG. "ELECTROCHEMICAL PROPERTIES OF SiC-C MICROELECTRODE SYSTEM FOR NEURONAL AND BIOCHEMICAL SENSING." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1123783498.

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20

Riaz, Muhammad Qasim. "Influence of Biochemical Environments on Surface Fatigue of Additive Manufactured Ti-6Al-4V." Youngstown State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1485534165584066.

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21

Vadrevu, Suryakiran. "Biochemical investigation of phosphodiesterase type IV post-translational modification, cellular localisation and interaction with associated binding proteins." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/219/.

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cAMP is a secondary messenger that is involved in a variety of signalling pathways through its effectors including EPAC, PKA and ion channels. cAMP signalling regulates processes such as memory, muscle contraction and inflammatory responses. PDE enzymes offer a mechanism to negatively regulate elevated cAMP levels elicited by activators of adenylyl cyclase. Studies have shown that cAMP signalling is compartmentalised through binding of PDEs to A-kinase anchoring proteins (AKAPs) that scaffold PKA regulatory subunits. In this study post-translational-modification of PDE4 isoforms is investigate
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22

Geldenhuys, Greta. "Egyptian goose (Alopochen aegyptiacus) : sensory, biochemical and physical meat quality as affected by gender, diet and ageing." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/95871.

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Thesis (PhD(Food Sc))--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: In Southern Africa, the hunting of wildfowl species has increased considerably in the past few years. Crop farmers incur major financial losses due to the feeding activities of Egyptian geese (Alopochen aegyptiacus); consequently a large number of geese are hunted in an attempt to reduce the damage caused. With the current absence of scientific information baseline research investigating the meat quality of this species is essential. The sensory profile of Egyptian goose meat was found to be very distinct in relation t
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23

Young, David. "Spectroscopic, structural, mutational and biochemical characterisation of quinol-dependent nitric oxide reductase of Neisseria meningitidis." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2034441/.

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Quinol-dependent nitric oxide reductase (qNOR) is a homodimeric, membrane-bound metalloenzyme with the catalytic function of reducing two molecules of nitric oxide to nitrous oxide. In bacteria, qNOR can serve either as a respiratory enzyme, or in pathogens as a defence mechanism against cytotoxic levels of nitric oxide radicals generated by the host immune response. One such pathogen is Neisseria meningitidis, a cause of meningitis and septicaemia worldwide. Various biochemical, biophysical, and computational techniques have been applied in study of the molecular mechanism underlying the redu
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24

Dyer, Scott Douglas. "Evaluation of the efficacy of the stress protein response as a biochemical water quality biomonitoring method." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc798352/.

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The stress protein response (SPR) is a conserved and ubiquitous mechanism that enables cells to tolerate a wide variety of environmental insults. This response involves the preferential synthesis of an array of proteins with different molecular weights. These proteins perform a variety of functions, such as protein folding, multimeric protein assembly, steroid receptor binding, and heme catabolism. To evaluate the potential use of the SPR as a biomonitoring tool, a stepwise plan was utilized that proceeded through various physical and chemical laboratory exposures and culminated with a field
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25

Vandongen, Robert. "[Biochemical and epidemiological basis of hypertension] : published works submitted to the University of Adelaide for the degree of Doctor of Science /." Title page and summary only, 1987. http://web4.library.adelaide.edu.au/theses/09SD/09sdv246.pdf.

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26

Baeza, Rita. "Comparison of technologies to control the physiological, biochemical and nutritional changes of fresh cut fruit." Manhattan, Kan. : Kansas State University, 2007. http://hdl.handle.net/2097/494.

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27

Lauer, Nathan T. "Physiological and Biochemical Responses of Bald Cypress to Salt Stress." UNF Digital Commons, 2013. http://digitalcommons.unf.edu/etd/454.

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Bald Cypress (Taxodium distichum (L.) Rich.) is native to freshwater wetlands of Florida. The vitality of cypress within coastal freshwater wetlands is threatened by saltwater intrusion. Biomarkers to detect sub-lethal salinity stress were developed using a controlled greenhouse study. Cypress saplings maintained at elevated salinities of 4 and 8‰ exhibited a decrease in maximum quantum yield (MQY) and an increase in non-photochemical quenching (NPQ). Cypress leaves exhibited an increase in Na+, H2O2, and free proline content compared to plants maintained in freshwater. These biomarkers were u
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28

Changsawang, Narin. "The effects of growth conditions on the elemental and biochemical composition of the diatom Thalassiosira weissflogii and the haptophyte Emiliania huxleyi." Thesis, University of Essex, 2015. http://repository.essex.ac.uk/15697/.

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A change in environmental conditions often leads to changes of physiology and biochemical composition of microalgae. Temperature and light intensity are important environmental factors regulating the growth of microalgae. In this study, the elemental and biochemical composition were measured in 2 marine microalgae under different temperatures and light intensities in nutrient replete and deplete conditions. The effect of temperature was observed in the marine haptophyte Emiliania huxleyi (CCMP 1516) at nutrient replete semi-continuous cultures. Triplicate cultures were incubated different temp
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29

Al, Mohamad Zakriya Ali E. "Quantitative assessment of the biochemical composition of equine cartilage using 7T ultra-high field magnetic resonance imaging (MRI) techniques." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/8227/.

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Equine fetlock region disease is responsible for significant morbidity and mortality. Diagnosis of sesamoidean ligament, cartilage and subchondral bone injury has been obtained by clinical MRI. Low-field MRI provides images helpful in the investigation of MCPJ/MTPJ region pathology in horses in the clinical setting but the greater resolution of high and ultra-field MR images has the potential to aid interpretation through a better understanding of MRI anatomy. Quantitative MRI could provide a non-invasive technique to determine tissue biochemical properties associated with the early onset of a
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30

Matchett, Ashley A. "Genetic and biochemical analysis of materials from a medieval population from Ynys Mon North Wales." Thesis, University of Central Lancashire, 2011. http://clok.uclan.ac.uk/3880/.

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The archaeological excavation of the early medieval site at Towyn-Y-Capel on the island of Anglesey (Ynys Môn) in North Wales, UK, provided the opportunity to study a large population (122 skeletons) at a site that was in use over a period of up to 550 years (650 -1200 AD). Samples of skeletal materials for this study were taken directly from the site itself .The osteological condition of skeletal material was variable across the site. In general, the upper burials in particular were in the poorest condition, and were mainly fragmented and dispersed due to the ongoing site erosion and diagenet
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31

Chou, Lan-Szu. "Isolation and Biochemical Characterization of Acid- and Bile- Tolerant Strains of Lactobacillus Acidophilus and Bifidobacterium Bifidum." DigitalCommons@USU, 1997. https://digitalcommons.usu.edu/etd/5427.

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Lactic acid bacteria have been reported to be used as a health adjunct in food for u many years. However, these health benefits have not been proven. and how these bacteria pass through the digestion process and remain viable in the human intestinal tract is still not clear. The aim of this work was to isolate mutants from Lactobacillus acidophilus or Bifidobacterium bifidum that could tolerate the conditions of the digestion process (low pH and bile conduction) and to characterize these isolated mutants. Acid- and bile-tolerant mutants of L. acidophilus were isolated from parental strains suc
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32

Halling, Linder Cecilia. "Biochemical and functional properties of mammalian bone alkaline phosphatase isoforms during osteogenesis." Doctoral thesis, Linköpings universitet, Avdelningen för mikrobiologi och molekylär medicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-127100.

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The human skeleton is a living and dynamic tissue that constantly is being renewed in a process called bone remodeling. Old bone is resorbed by osteoclasts and new bone is formed by osteoblasts. Bone is a composite material made up by mineral crystals in the form of hydroxyapatite (calcium and phosphate) that provides the hardness of bone, and collagen fibrils that provides elasticity and flexibility. Alkaline phosphatase (ALP) is a family of enzymes that is present in most species and catalyzes the hydrolysis of various phosphomonoesters at alkaline pH. Despite the generalized use of ALP as a
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33

Bolton, Shawna N. "Forensic taphonomy : investigating the post mortem biochemical properties of cartilage and fungal succession as potential forensic tools." Thesis, University of Wolverhampton, 2015. http://hdl.handle.net/2436/579577.

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Post mortem interval (PMI – the time elapsed since death and discovery) is important to medicolegal investigations. It helps to construct crucial time lines and assists with the identification of unknown persons by inclusion or exclusion of a suspect’s known movements. Accurate methodologies for establishing PMI are limited to about 48-hours. Such methods involve use of increasing levels of potassium in vitreous humour, and algor mortis. This study is two-fold. Firstly, it explores the biomolecular changes in degrading porcine cartilage buried in soil environments and its potential to determin
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34

Bergendahl, Christina. "Development of competence in biochemical experimental work : Assessment of complex learning at university level." Doctoral thesis, Umeå : Dept. of Chemistry, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-313.

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35

Martinenko, Evgeny. "Prediction of survival of early stages lung cancer patients based on ER beta cellular expressions and epidemiological data." Master's thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4796.

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We attempted a mathematical model for expected prognosis of lung cancer patients based on a multivariate analysis of the values of ER-interacting proteins (ERbeta) and a membrane bound, glycosylated phosphoprotein MUC1), and patients clinical data recorded at the time of initial surgery. We demonstrate that, even with the limited sample size available to use, combination of clinical and biochemical data (in particular, associated with ERbeta and MUC1) allows to predict survival of lung cancer patients with about 80% accuracy while prediction on the basis of clinical data only gives about 70% a
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36

Ross, Trinette Noel. "Evaluation of bone biochemical markers and inflammatory markers in yearlings fed varying ratios of omega-6 and omega-3 polyunsaturated fatty acids." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1036.

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37

Schlipf, Daniel M. "BIOMOLECULE LOCALIZATION AND SURFACE ENGINEERING WITHIN SIZE TUNABLE NANOPOROUS SILICA PARTICLES." UKnowledge, 2015. http://uknowledge.uky.edu/cme_etds/44.

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Mesoporous silica materials are versatile platforms for biological catalysis, isolation of small molecules for detection and separation applications. The design of mesoporous silica supports for tailored protein and biomolecule interactions has been limited by the techniques to demonstrate biomolecule location and functionality as a function of pore size. This work examines the interaction of proteins and lipid bilayers with engineered porous silica surfaces using spherical silica particles with tunable pore diameters (3 – 12 nm) in the range relevant to biomolecule uptake in the pores, and la
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38

Gupta, Prachi. "SYNTHESIS AND CHARACTERIZATION OF ANTIOXIDANT CONJUGATED POLY(ΒETA-AMINO ESTER) MICRO/NANOGELS FOR THE SUPPRESSION OF OXIDATIVE STRESS". UKnowledge, 2016. http://uknowledge.uky.edu/cme_etds/58.

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Oxidative stress is a pathophysiological condition defined by an increased production of reactive oxygen species (ROS), which can result in the growth arrest of cells followed by cell disintegration or necrosis. A number of small molecule antioxidants (e.g. curcumin, quercetin and resveratrol) are capable of directly scavenging ROS, thereby short-circuiting the self-propagating oxidative stress state. However, poor solubility and rapid 1st pass metabolism results in overall low bioavailability and acts as a barrier for its use as a drug to suppress oxidative stress efficiently. To overcome thi
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39

Larsson, Birgitta. "Physiological Importance of 1,25(OH)2D3 Membrane-Initiated and Nuclear Actions in Chickens as a Function of Growth, and Maturation in Male and Female Chickens." DigitalCommons@USU, 2002. https://digitalcommons.usu.edu/etd/5500.

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It is well established that l,25(OH)2D3 is a major regulator of calcium homeostasis. The steroid exerts its effects on its target organs by two mechanisms, a slow mechanism mediated by nuclear vitamin D receptors (nVDR), and a rapid mechanism mediated by the l,25(OH)2D3 membrane-associated rapid response steroid binding protein (l,25D3-MARRS bp). In this dissertation, the physiological relevance of membrane initiated steroid signaling was investigated by studying the correlation of age in male and female chickens with the magnitude of responses to l,25(OH)2D3 in duodena from 7-, 14-, 28-, and
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40

Jia, Yang. "FORMS OF SUPPLEMENTAL SELENIUM IN VITAMIN-MINERAL MIXES DIFFERENTIALLY AFFECT SEROLOGICAL AND HEPATIC PARAMETERS OF GROWING BEEF STEERS GRAZING ENDOPHYTE-INFECTED TALL FESCUE." UKnowledge, 2019. https://uknowledge.uky.edu/animalsci_etds/97.

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Consumption of endophyte-infected tall fescue results in a syndrome of negatively altered physiological systems, collectively known as fescue toxicosis. Another challenge to endophyte-infected tall fescue -based beef cattle operations is that the soils often are selenium (Se) poor, necessitating the need to provide supplemental Se. To test the general hypothesis that different forms of supplemental Se would ameliorate the negative effects of fescue toxicosis, predominately-Angus steers (BW = 183 ± 34 kg) were randomly selected from herds of fall-calving cows grazing an endophyte-infected tall
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41

Ahn-Jarvis, Jennfier H. "Development of a standardized functional soy product for cancer prevention trials:Phase II evaluation of isoflavone bioavailability in men with asymptomatic prostate cancer." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1357255127.

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42

Liu, Yunhao. "Structural and biochemical analysis of HutD from Pseudomonas fluorescens SBW25 : a thesis submitted in fulfilment of the requirements for the degree of Master of Science in Molecular Biosciences at Massey University, Auckland, New Zealand." Massey University, 2009. http://hdl.handle.net/10179/1074.

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Pseudomonas fluorescens SBW25 is a gram-negative soil bacterium capable of growing on histidine as the sole source of carbon and nitrogen. Expression of histidine utilization (hut) genes is controlled by the HutC repressor with urocanate, the first intermediate of the histidine degradation pathway, as the direct inducer. Recent genome sequencing of P. fluorescens SBW25 revealed the presence of hutD in the hut locus, which encodes a highly conserved hypothetical protein. Previous genetic analysis showed that hutD is involved in hut regulation, in such a way that it prevents overproduction of th
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43

Tao, Jing. "Treatment of sanitary sewer overflow using fixed media bioreactors." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1228071779.

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44

Authimoolam, Sundar Prasanth. "BIOMIMETIC ORAL MUCIN FROM POLYMER MICELLE NETWORKS." UKnowledge, 2015. http://uknowledge.uky.edu/cme_etds/51.

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Mucin networks are formed by the complexation of bottlebrush-like mucin glycoprotein with other small molecule glycoproteins. These glycoproteins create nanoscale strands that then arrange into a nanoporous mesh. These networks play an important role in ensuring surface hydration, lubricity and barrier protection. In order to understand the functional behavior in mucin networks, it is important to decouple their chemical and physical effects responsible for generating the fundamental property-function relationship. To achieve this goal, we propose to develop a synthetic biomimetic mucin using
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45

Sims, Lynn. "Biochemical Studies of ABCE1." Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5501.

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The growth and survival of all cells require functional ribosomes that are capable of protein synthesis. The disruption of the steps required for the function of ribosomes represents a potential future target for pharmacological anti-cancer therapy. ABCE1 is an essential Fe-S protein involved in ribosomal function and is vital for protein synthesis and cell survival. Thus, ABCE1 is potentially a great therapeutic target for cancer treatment. Previously, cell biological, genetic, and structural studies uncovered the general importance of ABCE1, although the exact function of the Fe-S cluster
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46

Djerdjouri, Nour-Eddine. "Hydrogen peroxide delignification in a biomimetic system based on manganese peroxidase." Diss., Available online, Georgia Institute of Technology, 2005, 2003. http://etd.gatech.edu/theses/available/ipstetd-1017/.

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47

Thakkar, Jay. "Biochemical Evaluation of Lignin-like Molecules." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/199.

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Current anticoagulants carry a serious risk of bleeding complications. In addition, narrow therapeutic index, drug interactions, immunological reactions, toxicity and high cost to benefit ratio limits the effective use of these drugs in patients with thrombotic conditions.Heparin is the most widely used anticoagulant. We hypothesized that one of the major drawback of heparins, its non-specific interaction with the plasma proteins arises as a result of negative charges. To reduce these non-specific interactions, our laboratory designed sulfated low molecular weight lignin (LMWL) like biomacromo
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48

Zhou, Jin Chuan. "Biochemical characterisation of KDM2A." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:030faa1d-5d3c-4066-9e9f-a44cd13cf85c.

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Mammalian genomes are characterised by unique regions of non-methylated DNA known as CpG islands (CGIs). These genomic elements are characterised by a high density of CpGs and an elevated GC content compared to the surrounding, bulk of the genome. CGIs are prevalently associated with the 5’ end of genes and represent key nucleation sites where specific transcription factors and chromatin modifiers are recruited to impact on gene function. This thesis is focused at understanding the biochemical properties of the recently discovered H3K36-specific histone demethylase, KDM2A. This enzyme is speci
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49

Soda, Takahiro. "Converging biochemical pathways in psychiatric disorders." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/73775.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>According to the World Health Organization, neuropsychiatric diseases account for approximately one third of years lost to disability. Yet, despite this huge disease burden, there is a lack of new treatments under development: approved treatments all essentially target the same target(s), if the target itself is known. There is now considerable evidence for a common set of heritable risk for psychiatric disorder
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50

Pooler, Amy Melissa. "Regulation of biochemical pathways involved in neurodegeneration." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/31177.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2005.<br>Includes bibliographical references.<br>Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and memory loss. Although much is known about how AD affects the brain, the cause of this disease remains elusive. Current AD treatments target symptoms of the disease but do not prevent or slow the underlying neurodegeneration. Therefore, research into the biochemical mechanisms of AD is necessary in order to develop a better understanding of how to treat it. M
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