Tesis sobre el tema "Bile Acids"
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Li, Hai. "Bile acids enterohepatic circulation". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2005. http://dare.uva.nl/document/77982.
Texto completoZhu, Xiao Xia. "Binding interactions of bile acids and bile pigments with amines". Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75846.
Texto completoNew adsorbents for bilirubin have been prepared by covalently coating a water-swellable polyamide resin with polypeptides. These resins have much higher capacities for bilirubin in aqueous buffer solution than cholestyramine and improved capacities over the resins with attached oligopeptide pendants. The binding behavior of the resin coated with poly- sc D-lysine is the same as that of poly- sc L-lysine. The amount of bilirubin adsorbed by these resins is directly proportional to the number of lysine residues on the resin, which is consistent with the formation of an ionic linkage. This is confirmed by a study of the interaction of bilirubin with an oligopeptide, sc L-lysyl- sc L-lysine, by measurements of proton and carbon-13 NMR spin-lattice relaxation times combined with nitrogen-15 NMR experiments. The $ sp{15}$N NMR spectra of bilirubin and some related bile pigments have also been assigned by two-dimensional $ sp{15}$N-$ sp1$H heteronuclear correlation experiments.
Rao, Girish. "Enzyme electrode studies of bile acids". Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/11881.
Texto completoBradburn, David Michael. "Bile acids and short fatty acids in familial adenomatous polyposis". Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308760.
Texto completoTrusova, Tatyana. "Quantitative estimation of bile acid conjugates in human bile using HPLC /". Connect to online version, 1995. http://hdl.handle.net/1989/3555.
Texto completoQian, Jiang. "Studies of Sulfur Reduction of Taurine and Taurine-Conjugated Bile Acids by Bile acid 7α-Dehydroxylating Bacteria". TopSCHOLAR®, 2000. http://digitalcommons.wku.edu/theses/694.
Texto completoMcNeilly, Alison Delamere. "The impact of bile acids on glucocorticoid metabolism". Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/24968.
Texto completoLeonard, Danièle. "Adsorption of bile acids by ion-exchange resins". Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74309.
Texto completoIon-exchange resins were prepared by solid phase peptide synthesis with active sites chosen to resemble those of cholestyramine. They were produced by coupling 4-(aminomethyl)benzoic acid, 4-aminophenylacetic acid or 4-(aminomethyl)phenylacetic acid to the backbone. The ion-exchange resins were prepared both as primary amines and in the quaternized form. The cholestyramine-like sorbents were synthesized with systematic changes in the structure, to determine which structural parts of cholestyramine are involved in the adsorption process. As compared to cholestyramine, both sets of resins were remarkably ineffective in adsorbing bile acids in vitro. It was found that the nature of the backbone determines the accessibility to the active site; that the resins with the methylene group positioned between the phenyl group and the amino group have higher adsorption capacity for glycocholic acid; and that quaternization increases the adsorption capacity. The two latter observations indicate the importance of the basicity of the active site. Therefore, in cholestyramine, the backbone is such that it permits the transfer of ionic species and the quaternary ammonium group is involved in the interaction with bile acids.
Computer modelling showed that the cholestyramine pendants are close to one another and are separated by benzene rings, thus leaving too little space between them to allow a bile acid molecule to interact with the benzene rings. Therefore, the bile acids must interact with the quaternary ammonium group, leaving the bile acid molecule inside the cavity where they interact with one another to form micelles. The possible modes of interactions of bile acids with the synthesized resins are more numerous since the pendants are not as close together. (Abstract shortened by UMI.)
Zeck, Lisa. "Optimization of an immobilized enzyme system for conjugated bile acids /". Connect to online version, 1995. http://hdl.handle.net/1989/3548.
Texto completoBarker, Gillian M. "Bile acids and neutral sterols in familial adenomatous polyposis". Thesis, University of Aberdeen, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308002.
Texto completoBadiee, Mohsen. "Mechanistic Insights intoThe Physiology of Bile acids and Retinoids". Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1505919467280191.
Texto completoNguyen, Elizabeth Ann Gaddi. "The Regulation of Bile Acids on NHE8 Gene Expression". Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/297714.
Texto completoEllis, Ewa C. S. "Use of primary human hepatocytes for elucidation of bile acid synthesis /". Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-424-0.
Texto completoBajor, Antal. "Bile acid induced diarrhoea : pathophysiological and clinical aspects /". Göteborg : Dept. of Internal Medicine, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, 2008. http://hdl.handle.net/2077/9840.
Texto completoMurphy, Charlotte. "Studies on the regulatory roles of cholesterol and bile acids /". Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-173-9/.
Texto completoKehring, Allysa. "Bile Acids to Predict the Developments of Neonatal Necrotizing Enterocolitis". Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146074.
Texto completoTierney, Juliann Jude. "The synthesis and testing of novel cholic acid based stationary phases". Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247854.
Texto completoJean-Louis, Samira. "Membrane Perturbation By Bile Acids and Their Potential Role in Signaling". Tucson, Arizona : University of Arizona, 2006. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1471%5F1%5Fm.pdf&type=application/pdf.
Texto completoLowe, Gordan M. "Biochemical and genetic aspects of the microbial degradation of bile acids". Thesis, Liverpool John Moores University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305858.
Texto completoObuseng, Veronica Conie. "Bile acids as indicator of faecal inputs into soils and sediments". Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391155.
Texto completoElhmmali, Mohamed Mimoun. "Complementary use of bile acids and sterols as sewage pollution indicators". Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245524.
Texto completoJean-Louis, Samira. "Membrane Perturbation By Bile Acids and Their Potential Role in Signaling". Diss., The University of Arizona, 2005. http://hdl.handle.net/10150/193551.
Texto completoOpiyo, Monica Naomi. "The role of glucocorticoid metabolism in bile acid homeostasis". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25673.
Texto completoTo investigate the role of hepatic 11β-HSD1 specifically, 11β-HSD1 liver-specific knockout (Hsd11b1LKO), 11β- HSD1 liver-specific over-expressors (Hsd11b1LOE) and control mice with exon 3 of the Hsd11b1 gene “floxed” (Hsd11b1F) were studied. Findings from this study indicate a role for 11β-HSD1 in adaption to dietary cholesterol and suggest that hepatic 11β-HSD1 (as opposed to 11β-HSD1 in extra-hepatic tissues) is the main factor regulating BA metabolism. Also, work from this thesis demonstrates 11β-HSD1 is an important regulator of gall bladder emptying and filling, an important component of enterohepatic bile acid recycling. Based on these findings it is anticipated that therapeutic use of 11β-HSD1 inhibitors will result in BA imbalances within the enterohepatic circuit and therefore BA homeostasis. Care must therefore be observed when implementing therapeutic use of 11β-HSD1 inhibitors, with particular focus on patients with cholestasis, Addison’s disease and critically ill patients who already have known BA imbalances in their enterohepatic system.
Werry, Brian Scott. "Characterizing Bile Acid Association as a Ligand and in Micellization". Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1386186690.
Texto completoHarris, Spencer. "Discovery and characterization of bile acid and steroid metabolism pathways in gut-associated microbes". VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4713.
Texto completoChen, Fei Wen. "Lean NAFLD: A distinct entity shaped by differential metabolic adaptation". Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/22240.
Texto completoChoucair, Ibrahim. "GUT MICROBE METABOLISM OF BILE ACIDS AND THEIR RELATIONSHIP TO CARDIOMETABOLIC DISEASES". Cleveland State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=csu1570190994304441.
Texto completoMilona, Alexandra. "Role of FXR in the adaptive response to bile acids during pregnancy". Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/4727.
Texto completoMooranian, Armin. "Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus". Thesis, Curtin University, 2018. http://hdl.handle.net/20.500.11937/70687.
Texto completoISHII, AKIRA, HIROSHI SENO, HIDEKI HATTORI, TADASHI OGAWA, TAMIE NAKAJIMA, KAZUYA KITAMORI, HISAO NAITO, MINA NOMURA, RINA KANEKO y YUDAI SUZUKI. "Simple and Rapid Quantitation of 21 Bile Acids in Rat Serum and Liver by UPLC-MS-MS: Effect of High Fat Diet on Glycine Conjugates of Rat Bile Acids". Nagoya University School of Medicine, 2013. http://hdl.handle.net/2237/17602.
Texto completoMorgan, Sherif. "The Bile Acid, Deoxycholic Acid, Modulates IGF-IR Function in Colon Cancer Cells". Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194122.
Texto completoGälman, Cecilia. "Modulation of bile acid and cholesterol metabolism in health and disease /". Stockholm ; Karolinska institutet, 2004. http://diss.kib.ki.se/2004/91-7349-948-x.
Texto completoPULEO, Gianluigi. "Synthesis and use of bile acid derived organocatalysts". Doctoral thesis, Scuola Normale Superiore, 2009. http://hdl.handle.net/11384/85788.
Texto completoCheah, Peh Yean. "The DNA-damaging effect of bile acids and the protective effect of cellulose". Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184639.
Texto completoGlinghammar, Björn. "Toxicological aspects of bile acids and human fecal water on cultered human colon carcinoma cells /". Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4816-x/.
Texto completoMünch, Andreas. "Collagenous colitis : The influence of inflammation and bile acids on intestinal barrier function". Doctoral thesis, Linköpings universitet, Gastroenterologi och hepatologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-56291.
Texto completoSpeight, Richard Alexander. "The role of bile acids and farnesoid X receptor in ileal Crohn's disease". Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/3078.
Texto completoZhang, Xuejun. "Branched and spiral organic nanotubes based on the self-assembly of bile acids". Master's thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4542.
Texto completoID: 029051028; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Thesis (M.S.)--University of Central Florida, 2010.; Includes bibliographical references.
M.S.
Masters
Department of Mechanical, Materials and Aerospace Engineering
Engineering and Computer Science
Materials Science and Engineering
Lundåsen, Thomas. "Studies on the hormonal regulation of bile acid synthesis /". Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-053-4/.
Texto completoBaxter, Debbie Jane. "Molecular mechanisms of biliary lipid secretion". Thesis, Liverpool John Moores University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298908.
Texto completoDelsol, Anne Aline Germaine. "Microbial 7-hydroxylation of the steroid lithocholic acid : a novel approach to produce bile acids for gallstone therapy". Thesis, University of Exeter, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297640.
Texto completoCastellanos, jankiewicz Ashley. "Bile acids signaling as a novel mechanism in the hypothalamic control of energy balance". Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0218.
Texto completoIntroduction: Bile acids (BA) are cholesterol-derived molecules mostly known for their role in digesting lipids. By activating the Takeda G protein coupled receptor 5 (TGR5) in peripheral organs, they can also act as signaling molecules to reduce body weight and improve glucose homeostasis. Notably, TGR5 activation can increase energy expenditure in brown adipocytes, although the metabolic pathways involved in these effects are not yet clear. These outcomes imply an anti-obesity function for TGR5. However, all studies investigating BA in energy balance have exclusively focused on peripheral tissues. Since the major center of convergence of nutrient, hormonal, and environmental cues is the brain, particularly the hypothalamus, we hypothesized a role for TGR5 in this brain structure, suggesting that hypothalamic TGR5 activity may participate in energy balance, specifically under dietinduced obesity. Objective: To demonstrate the function of the BA – TGR5 system in hypothalamic populations known to control energy homeostasis, and disentangle its relevance for the treatment of diet-induced obesity. Methods: C57Bl6/J male mice that were either lean (standard chow) or diet-induced obese (60% high-fat diet; HFD) were implanted with an intra-cerebroventricular (ICV) cannula for the pharmacological delivery of TGR5 agonists. TGR5flox/flox mice were used to target the sitespecific deletion of the receptor within the mediobasal hypothalamus (MBH), through the stereotaxic delivery of AAV-Cre. The following metabolic outputs were measured: body weight, food intake, body composition (EchoMRI analyzer), insulin sensitivity, serum and hypothalamic BA (liquid mass spectrometry), and energy expenditure (TSE Phenomaster system). To block sympathetic signaling, we exposed mice to thermoneutrality (30°C) or performed chemical sympathectomy (6-hydroxydopamine; 80mg/kg i.p.). Markers of lipolysis, thermogenesis, and thyroid metabolism were measured in the liver, adipose and hypothalamic tissues by qPCR or western blots. All studies received the approval from the animal ethical committee of the University of Bordeaux. Results: We demonstrate that TGR5 and BA transporters are expressed in the MBH and that diet-induced obese mice have decreased circulating and hypothalamic BA. Acute ICV or intra-MBH administration of TGR5 agonists reduced food intake and body weight in dietinduced obese mice only, and improved insulin sensitivity. Accordingly, chronic ICV administration of the TGR5 agonist in obese mice reduced their body weight and adiposity, while increasing energy expenditure and mRNA markers of sympathetic activity in the adipose tissue. Indeed, experiments conducted at thermoneutrality or chemical sympathectomy blunted these effects, demonstrating that central TGR5 effects require an enhanced sympathetic tone. By using TGR5flox/flox mice coupled with the delivery of an AAVCre, we observed that the deletion of TGR5 in the MBH had no effect in chow-fed mice. However, a HFD switch rapidly increased their body weight, food intake and adiposity. When exposed to the cold (4 h at 4°C), protein levels of lipolysis and thermogenesis markers in the adipose tissue were blunted, implying an interruption in sympathetic signaling to the periphery due to hypothalamic downregulation of TGR5. Lastly, Cre-dependent deletion of TGR5 in the MBH of already obese mice rapidly increased adiposity by inducing hyperphagia, worsening their obese phenotype. Conclusions: Our work proves the existence of a functional hypothalamic BA – TGR5 receptor system. We show for the first time that the activation of TGR5 in the MBH decreases body weight and adiposity, while increasing energy expenditure through recruitment of the sympathetic nervous system. Taken together, these results expose a new mechanism of action for potential anti-obesity therapies
Kandell, Risa Lynne. "Bile acid-induced DNA damage and repair in bacterial and mammalian cells". Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/184976.
Texto completoCheng, Jeffrey Binyan. "CDNA cloning and characterization of enzymes that synthesize bile acids, vitamin D and waxes". Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=150.
Texto completoAdebola, Oluwakemi. "The relationship between probiotics, prebiotics and bile acids and the impact on gut health". Thesis, University of East London, 2009. http://roar.uel.ac.uk/3196/.
Texto completoKaler, Balwant. "The role of bile acids in kidney failure as a result of obstructive jaundice". Thesis, University of East London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264409.
Texto completoMiró, Richart Paula. "Hydrogen-Abstraction, Energy Transfer and Exciplex Formation in Photoactive Systems Based on Bile Acids". Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/64084.
Texto completo[ES] Los ácidos biliares son una familia de esteroides anfifílicos que juegan un papel clave en diferentes funciones fisiológicas tales como la eliminación del colesterol o la solubilización de lípidos. Su estructura química está constituida por un esqueleto esteroideo con una fusión cis poco común entre los anillos A y B, una cadena lateral corta que termina con una función ácida y un número variable de grupos hidroxilo en la cara alfa. Por tanto, los ácidos biliares ofrecen una estructura versátil que puede ser utilizada para investigar procesos fotofísicos de interés como abstracción de hidrógeno, transferencia de energía y formación de exciplejos a larga distancia o reacciones relacionadas con el daño fotoinducido al ADN. En esta Tesis, en primer lugar, los ácidos biliares naturales se han utilizado para evaluar la abstracción de hidrógeno a carbonilos triplete en compuestos derivados de la benzofenona, demostrándose la deshidrogenación de los ácidos biliares en las posiciones C-3 y/o C-7 por un mecanismo radicalario desde el mencionado triplete de la benzofenona. En segundo lugar, se han preparado derivados de ácido litocólico que incluyen los dadores benzofenona o carbazol y los aceptores naftaleno, bifenilo o timina, que a continuación se han utilizado para investigar los procesos de transferencia de energía y formación de exciplejo intramolecular a larga distancia. De hecho, en los sistemas benzofenona/naftaleno y benzofenona/bifenilo, se demostró por fotólisis de destello láser la transferencia de energía desde benzofenona a naftaleno o bifenilo y la formación de exciplejo a larga distancia. Por último, se han preparado derivados de ácidos bliares que incorporan una unidad de benzofenona y dos de timina en diferentes posiciones del esqueleto para investigar la influencia de los diferentes grados de libertad en la formación fotosensibilizada de oxetanos o dímeros de timina. Gracias a ellos, se ha demostrado la formación fotosensibilizada de dímeros ciclobutánicos pirimidínicos a través de la generación de estados excitados triplete deslocalizados en sistemas en los que la benzofenona es intermolecular, mientras que se observa formación de oxetanos cuando los grados de libertad se ven reducidos.
[CAT] Els àcids biliars són una família d'esteroides anfifílics que juguen un paper clau en funcions fisiològiques com l'eliminació del colesterol o la solubilització de lípids. La seua estructura química està constituïda per un esquelet esteroïdal amb una fusió cis entre els anells A i B poc comuna, una cadena lateral curta que acaba amb una funció àcida i un nombre diferent de grups hidroxil en la cara alfa. D'aquesta manera, els àcids biliars ofereixen una estructura versàtil que pot ser utilitzada per investigar processos fotofísics d'interès com abstracció d'hidrogen, transferència d'energia i formació de exciplexes a llarga distància o reaccions relacionades amb el dany a l'ADN induït per llum. En primer lloc, els àcids biliars naturals s'han utilitzat per avaluar la abstracció d'hidrogen a carbonils triplets derivats de la benzofenona, demostrant-se la deshidrogenació dels àcids biliars en les posicions C-3 i/o C-7 per un mecanisme radicalari des de l'estat excitat de la benzofenona. A més, derivats d'àcid litocòlic que inclouen els donadors benzofenona o carbazol i els acceptors naftalé, bifenil o timina s'han utilitzat per investigar els processos de transferència d'energia i formació de exciplexe a llarga distància. En els sistemes benzofenona /naftalé i benzofenona/bifenil la fotòlisis làser va demostrar la transferència d'energia des de benzofenona a naftalé o bifenil i la formació d'exciplexe a llarga distància. Finalment, per tal d'investigar la formació fotosensibilitzada d'oxetans o dímers de timina, s'han preparat derivats d'àcids bliars que incorporen una unitat de benzofenona i dues de timina amb diferents graus de llibertat. La formació fotosensibilitzada de dímers ciclobutànics pirimidínics mitjançant la generació d'estats excitats triplet deslocalitzats ha estat demostrada en sistemes intermoleculars, mentre que la formació d'oxetans s'observa quan els graus de llibertat es veuen reduïts.
Miró Richart, P. (2016). Hydrogen-Abstraction, Energy Transfer and Exciplex Formation in Photoactive Systems Based on Bile Acids [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/64084
TESIS
Pournaras, Dimitrios. "Mechanisms maintaining reduced appetite and normoglycaemia after metabolic surgery : the role of bile acids". Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/10201.
Texto completoStyles, Nathan Allen. "The characterization of the subcellular localization of bile acid CoA:N-acyltransferase". Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2007p/styles.pdf.
Texto completoHan, Shuxin. "Vitamin D receptor regulation of cholesterol 7[alpha]-hydroxylase gene transcription and bile acid synthesis in human hepatocytes". [Kent, Ohio] : Kent State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1257459841.
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