Literatura académica sobre el tema "Bicoid-Hunchback"
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Artículos de revistas sobre el tema "Bicoid-Hunchback"
Janody, F., J. Reischl y N. Dostatni. "Persistence of Hunchback in the terminal region of the Drosophila blastoderm embryo impairs anterior development". Development 127, n.º 8 (15 de abril de 2000): 1573–82. http://dx.doi.org/10.1242/dev.127.8.1573.
Texto completoWolff, C., R. Schroder, C. Schulz, D. Tautz y M. Klingler. "Regulation of the Tribolium homologues of caudal and hunchback in Drosophila: evidence for maternal gradient systems in a short germ embryo". Development 125, n.º 18 (15 de septiembre de 1998): 3645–54. http://dx.doi.org/10.1242/dev.125.18.3645.
Texto completoMa, X., D. Yuan, K. Diepold, T. Scarborough y J. Ma. "The Drosophila morphogenetic protein Bicoid binds DNA cooperatively". Development 122, n.º 4 (1 de abril de 1996): 1195–206. http://dx.doi.org/10.1242/dev.122.4.1195.
Texto completoSchulz, C. y D. Tautz. "Autonomous concentration-dependent activation and repression of Kruppel by hunchback in the Drosophila embryo". Development 120, n.º 10 (1 de octubre de 1994): 3043–49. http://dx.doi.org/10.1242/dev.120.10.3043.
Texto completoGaul, U. y H. Jackle. "Analysis of maternal effect mutant combinations elucidates regulation and function of the overlap of hunchback and Kruppel gene expression in the Drosophila blastoderm embryo". Development 107, n.º 3 (1 de noviembre de 1989): 651–62. http://dx.doi.org/10.1242/dev.107.3.651.
Texto completoSommer, R. y D. Tautz. "Segmentation gene expression in the housefly Musca domestica". Development 113, n.º 2 (1 de octubre de 1991): 419–30. http://dx.doi.org/10.1242/dev.113.2.419.
Texto completoSchröder, Reinhard. "The genes orthodenticle and hunchback substitute for bicoid in the beetle Tribolium". Nature 422, n.º 6932 (abril de 2003): 621–25. http://dx.doi.org/10.1038/nature01536.
Texto completoMoudgil, Anshika, Ranbir Chander Sobti y Tejinder Kaur. "In-silico identification and comparison of transcription factor binding sites cluster in anterior-posterior patterning genes in Drosophila melanogaster and Tribolium castaneum". PLOS ONE 18, n.º 8 (17 de agosto de 2023): e0290035. http://dx.doi.org/10.1371/journal.pone.0290035.
Texto completoStauber, M., H. Taubert y U. Schmidt-Ott. "Function of bicoid and hunchback homologs in the basal cyclorrhaphan fly Megaselia (Phoridae)". Proceedings of the National Academy of Sciences 97, n.º 20 (19 de septiembre de 2000): 10844–49. http://dx.doi.org/10.1073/pnas.190095397.
Texto completoBonneton, François, Philip J. Shaw, Claire Fazakerley, Min Shi y Gabriel A. Dover. "Comparison of bicoid-dependent regulation of hunchback between Musca domestica and Drosophila melanogaster". Mechanisms of Development 66, n.º 1-2 (agosto de 1997): 143–56. http://dx.doi.org/10.1016/s0925-4773(97)00100-7.
Texto completoTesis sobre el tema "Bicoid-Hunchback"
Crauk, Olivier. "Exploration moléculaire de l' activité du gradient morphogénétique Bicoid dans l' embryon précoce de drosophile". Paris 6, 2005. http://www.theses.fr/2005PA066285.
Texto completoSchaeffer, Valérie. "Rôle de Bicoid chez la drosophile : intercations avec Hunchback et Torso". Montpellier 2, 1999. http://www.theses.fr/1999MON20102.
Texto completoLucas, Tanguy. "Spatio-temporal regulation of hunchback during the zygotic genome activation in Drosophila". Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066707.
Texto completoMorphogen gradients provide concentration-dependent positional information along polarity axes. Although the dynamics of these gradients is well described, precision and noise in the activation processes acting downstream remain unclear. To address this question, we study the response to the Bicoid gradient that elicits very rapidly a robust transcriptional response in young fly embryos. This robustness occurs despite the challenge imposed by frequent mitoses during which transcription is interrupted suggesting that nuclei measure the Bicoid concentration during the 5-6 mn interphases. Modeling using statistical mechanics and Bicoid physical parameters do not account for accurate measurement of Bicoid concentration in such a short period. It was proposed that rapid robustness of the Bicoid response relies on a memorization process allowing nuclei to recall Bicoid concentration from previous cycles. To understand how the Bicoid system resists to the challenge imposed by mitosis, I have adapted the MS2 RNA-tagging approach to fly embryos and shown that it can be used to quantify transcription dynamics in a living multicellular organism. Unexpectedly, the MS2 reporter was also expressed in the posterior of the embryo making it impossible to directly test the memorization hypothesis. I have shown that this posterior expression is due to binding sites for the transcription factor Zelda unexpectedly localized in the MS2 cassette. A newly engineered MS2 reporter removing those sites faithfully reproduces the endogenous expression providing a powerful tool to test the memory hypothesis. This work opens new avenue to decipher the transcription dynamics underlying pattern formation
Sasai, Masaki, Suguru Oho, Hiroki Murakami y Yurie Okabe-Oho. "Stable, Precise, and Reproducible Patterning of Bicoid and Hunchback Molecules in the Early Drosophila Embryo". PLOS, 2009. http://hdl.handle.net/2237/20618.
Texto completoShaw, Philip James. "Molecular characterisation of the interaction between the bicoid and hunchback genes in Musca domestica : insights into the evolution of a regulatory interaction". Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/30312.
Texto completoLucas, Tanguy. "Spatio-temporal regulation of hunchback during the zygotic genome activation in Drosophila". Electronic Thesis or Diss., Paris 6, 2015. http://www.theses.fr/2015PA066707.
Texto completoMorphogen gradients provide concentration-dependent positional information along polarity axes. Although the dynamics of these gradients is well described, precision and noise in the activation processes acting downstream remain unclear. To address this question, we study the response to the Bicoid gradient that elicits very rapidly a robust transcriptional response in young fly embryos. This robustness occurs despite the challenge imposed by frequent mitoses during which transcription is interrupted suggesting that nuclei measure the Bicoid concentration during the 5-6 mn interphases. Modeling using statistical mechanics and Bicoid physical parameters do not account for accurate measurement of Bicoid concentration in such a short period. It was proposed that rapid robustness of the Bicoid response relies on a memorization process allowing nuclei to recall Bicoid concentration from previous cycles. To understand how the Bicoid system resists to the challenge imposed by mitosis, I have adapted the MS2 RNA-tagging approach to fly embryos and shown that it can be used to quantify transcription dynamics in a living multicellular organism. Unexpectedly, the MS2 reporter was also expressed in the posterior of the embryo making it impossible to directly test the memorization hypothesis. I have shown that this posterior expression is due to binding sites for the transcription factor Zelda unexpectedly localized in the MS2 cassette. A newly engineered MS2 reporter removing those sites faithfully reproduces the endogenous expression providing a powerful tool to test the memory hypothesis. This work opens new avenue to decipher the transcription dynamics underlying pattern formation
Fernandes, Gonçalo. "Imaging transcription in living embryos to decipher the robustness of patterning". Electronic Thesis or Diss., Université Paris sciences et lettres, 2022. http://www.theses.fr/2022UPSLS025.
Texto completoMorphogen gradients provide concentration-dependent positional information required to establish the polarity of developmental axes. Although the critical role of these gradients is well recognized, it is unclear how they provide reproducible expression patterns. This is particularly surprising if we consider the stochastic nature of transcription.To address this question, I focus on the establishment of the anterior-posterior (AP) axis of fruit fly embryos, which is mostly defined by Bicoid (Bcd), a very well-characterized morphogen and transcription factor. bcd mRNAs are expressed maternally and anchored at the anterior tip of the oocyte. After egg laying, these mRNAs are translated into proteins, which diffuse through the cytoplasm and form a gradient with its highest concentration at the anterior. A simple model is that depending on their position along the AP axis and thus on Bcd concentration, cells will adopt different fates. However, long debates in the field have questioned the possibility that Bcd-dependent transcription patterns emerge solely from diffusive biochemical interactions between limiting amounts of Bcd molecules and the gene promoter region.The goal of my PhD was to determine how Bcd precisely regulates expression of its main target gene, hunchback (hb). For this, I adapted to synthetic reporters the MS2-MCP system, which allows the fluorescent tagging of mRNAs and provides, thus, a quantitative analysis of transcription dynamics at high spatiotemporal resolution in living embryos. In these reporters, the MS2 sequence was placed under the control of a minimal promoter also containing DNA binding sites for Bcd and/or its known partners, Hb and Zelda (Zld), either alone or in combination. My goal was to determine how the various reporters could recapitulate expression of the hb promoter (hb-MS2 reporter) and shed light on the specific roles of the different factors and their interactions in the transcription mechanism.Interestingly, expression of the reporter with only nine Bcd binding sites (three more than in the hb gene) matches almost perfectly the hb-MS2 reporter pattern, except for the very high steepness of the expression domain boundary and the speed to reach steady-state. This suggests that Bcd alone is the main source of positional information, defining the positioning of the boundary but not its steepness nor the speed of its establishment.In addition, binding of Bcd’s partners to the promoter speed-up the process by acting in different steps of the transcription mechanism: i) Hb synergizes with Bcd by reducing transcription burstiness and increasing the polymerase firing rate; ii) Zld lowers the Bcd concentration threshold required for Bcd-dependent expression. In collaboration with physicists, a biophysical model of Bcd-dependent expression was developed providing a theoretical framework for the experimental data. This model showed that the very rapid establishment of the hb expression boundary can be solely explained by an equilibrium model involving the binding of Bcd molecules to their DNA-binding sites for positional information which requires Zld and Hb for its temporal dynamics.To further confirm that Bcd is the sole source of positional information for hb expression, I compared the boundary position of the Bcd-only dependent reporters in embryos expressing one dose or half dose of Bcd. Surprisingly, the corresponding shifts of these reporters’ boundaries upon one vs half dose of Bcd were smaller than theoretically expected given the measured decay length of the Bcd protein gradient. This indicates a shorter decay length for the Bcd activity gradient and suggests the existence of different Bcd populations, with some Bcd molecules being less active than others. Importantly, the shift observed for the hb-MS2 reporter was the same as for the Bcd-only dependent reporters confirming Bcd as the sole source of positional information for hb expression
Lemke, Steffen Joachim. "Evolution of Bicoid-dependent hunchback Regulation in Diptera". Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-B366-A.
Texto completoLemke, Steffen [Verfasser]. "Evolution of bicoid-dependent hunchback regulation in diptera / submitted by Steffen Joachim Lemke". 2006. http://d-nb.info/987828843/34.
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