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Artículos de revistas sobre el tema "Barhl1"

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Autor: Grafiati
Publicado: 25 de mayo de 2024

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1

Hou, Kun, Hui Jiang, Md Rezaul Karim, Chao Zhong, Zhouwen Xu, Lin Liu, Minxin Guan, Jianzhong Shao y Xiao Huang. "A Critical E-box in Barhl1 3′ Enhancer Is Essential for Auditory Hair Cell Differentiation". Cells 8, n.º 5 (15 de mayo de 2019): 458. http://dx.doi.org/10.3390/cells8050458.

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Barhl1, a mouse homologous gene of Drosophila BarH class homeobox genes, is highly expressed within the inner ear and crucial for the long-term maintenance of auditory hair cells that mediate hearing and balance, yet little is known about the molecular events underlying Barhl1 regulation and function in hair cells. In this study, through data mining and in vitro report assay, we firstly identified Barhl1 as a direct target gene of Atoh1 and one E-box (E3) in Barhl1 3’ enhancer is crucial for Atoh1-mediated Barhl1 activation. Then we generated a mouse embryonic stem cell (mESC) line carrying disruptions on this E3 site E-box (CAGCTG) using CRISPR/Cas9 technology and this E3 mutated mESC line is further subjected to an efficient stepwise hair cell differentiation strategy in vitro. Disruptions on this E3 site caused dramatic loss of Barhl1 expression and significantly reduced the number of induced hair cell-like cells, while no affections on the differentiation toward early primitive ectoderm-like cells and otic progenitors. Finally, through RNA-seq profiling and gene ontology (GO) enrichment analysis, we found that this E3 box was indispensable for Barhl1 expression to maintain hair cell development and normal functions. We also compared the transcriptional profiles of induced cells from CDS mutated and E3 mutated mESCs, respectively, and got very consistent results except the Barhl1 transcript itself. These observations indicated that Atoh1-mediated Barhl1 expression could have important roles during auditory hair cell development. In brief, our findings delineate the detail molecular mechanism of Barhl1 expression regulation in auditory hair cell differentiation.
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2

Chellappa, Ramesh, Shengguo Li, Sarah Pauley, Israt Jahan, Kangxin Jin y Mengqing Xiang. "Barhl1 Regulatory Sequences Required for Cell-Specific Gene Expression and Autoregulation in the Inner Ear and Central Nervous System". Molecular and Cellular Biology 28, n.º 6 (22 de enero de 2008): 1905–14. http://dx.doi.org/10.1128/mcb.01454-07.

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ABSTRACT The development of the nervous system requires the concerted actions of multiple transcription factors, yet the molecular events leading to their expression remain poorly understood. Barhl1, a mammalian homeodomain transcription factor of the BarH class, is expressed by developing inner ear hair cells, cerebellar granule cells, precerebellar neurons, and collicular neurons. Targeted gene inactivation has demonstrated a crucial role for Barhl1 in the survival and/or migration of these sensory cells and neurons. Here we report the regulatory sequences of Barhl1 necessary for directing its proper spatiotemporal expression pattern in the inner ear and central nervous system (CNS). Using a transgenic approach, we have found that high-level and cell-specific expression of Barhl1 within the inner ear and CNS depends on both its 5′ promoter and 3′ enhancer sequences. Further transcriptional, binding, and mutational analyses of the 5′ promoter have identified two homeoprotein binding motifs that can be occupied and activated by Barhl1. Moreover, proper Barhl1 expression in inner ear hair cells and cerebellar and precerebellar neurons requires the presence of Atoh1. Together, these data delineate useful Barhl1 regulatory sequences that direct strong and specific gene expression to inner ear hair cells and CNS sensory neurons, establish a role for autoregulation in the maintenance of Barhl1 expression, and identify Atoh1 as a key upstream regulator.
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3

Li, Shengguo, Sandy M. Price, Hugh Cahill, David K. Ryugo, Michael M. Shen y Mengqing Xiang. "Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene". Development 129, n.º 14 (15 de julio de 2002): 3523–32. http://dx.doi.org/10.1242/dev.129.14.3523.

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The cochlea of the mammalian inner ear contains three rows of outer hair cells and a single row of inner hair cells. These hair cell receptors reside in the organ of Corti and function to transduce mechanical stimuli into electrical signals that mediate hearing. To date, the molecular mechanisms underlying the maintenance of these delicate sensory hair cells are unknown. We report that targeted disruption of Barhl1, a mouse homolog of the Drosophila BarH homeobox genes, results in severe to profound hearing loss, providing a unique model for the study of age-related human deafness disorders. Barhl1 is expressed in all sensory hair cells during inner ear development, 2 days after the onset of hair cell generation. Loss of Barhl1 function in mice results in age-related progressive degeneration of both outer and inner hair cells in the organ of Corti, following two reciprocal longitudinal gradients. Our data together indicate an essential role for Barhl1 in the long-term maintenance of cochlear hair cells, but not in the determination or differentiation of these cells.
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4

Lopes, Carmela, Anne-Lise Delezoide, Jean-Maurice Delabar y Mohammed Rachidi. "BARHL1 homeogene, the human ortholog of the mouse Barhl1 involved in cerebellum development, shows regional and cellular specificities in restricted domains of developing human central nervous system". Biochemical and Biophysical Research Communications 339, n.º 1 (enero de 2006): 296–304. http://dx.doi.org/10.1016/j.bbrc.2005.11.021.

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5

Dong, Hongyan, Carole L. Yauk y Michael G. Wade. "Barhl1 is directly regulated by thyroid hormone in the developing cerebellum of mice". Biochemical and Biophysical Research Communications 415, n.º 1 (noviembre de 2011): 157–62. http://dx.doi.org/10.1016/j.bbrc.2011.10.041.

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6

Pöschl, J., A. Lorenz, W. Hartmann, A. O. von Bueren, M. Kool, S. Li, A. Peraud et al. "Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans". Oncogene 30, n.º 47 (23 de mayo de 2011): 4721–30. http://dx.doi.org/10.1038/onc.2011.173.

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7

Sud, Richa, Chris M. Jones, Sandro Banfi y Sally J. Dawson. "Transcriptional regulation by Barhl1 and Brn-3c in organ of corti derived cell lines". Molecular Brain Research 141, n.º 2 (noviembre de 2005): 174–80. http://dx.doi.org/10.1016/j.molbrainres.2005.09.007.

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8

Barh, Debmalya, María García-Solano, Sandeep Tiwari, Antaripa Bhattacharya, Neha Jain, Daniel Torres-Moreno, Belén Ferri et al. "BARHL1 Is Downregulated in Alzheimer’s Disease and May Regulate Cognitive Functions through ESR1 and Multiple Pathways". Genes 8, n.º 10 (28 de septiembre de 2017): 245. http://dx.doi.org/10.3390/genes8100245.

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9

Li, S. "Barhl1 Regulates Migration and Survival of Cerebellar Granule Cells by Controlling Expression of the Neurotrophin-3 Gene". Journal of Neuroscience 24, n.º 12 (24 de marzo de 2004): 3104–14. http://dx.doi.org/10.1523/jneurosci.4444-03.2004.

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10

Li, Shengguo y Mengqing Xiang. "Barhl1 is required for maintenance of a large population of neurons in the zonal layer of the superior colliculus". Developmental Dynamics 235, n.º 8 (2006): 2260–65. http://dx.doi.org/10.1002/dvdy.20858.

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11

Bulfone, A. "Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS". Human Molecular Genetics 9, n.º 9 (22 de mayo de 2000): 1443–52. http://dx.doi.org/10.1093/hmg/9.9.1443.

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12

Rachidi, Mohammed y Carmela Lopes. "Differential transcription of Barhl1 homeobox gene in restricted functional domains of the central nervous system suggests a role in brain patterning". International Journal of Developmental Neuroscience 24, n.º 1 (27 de diciembre de 2005): 35–44. http://dx.doi.org/10.1016/j.ijdevneu.2005.11.015.

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13

Tu, Shu y Jian Zuo. "Systematic single cell RNA sequencing analysis reveals unique transcriptional regulatory networks of Atoh1-mediated hair cell conversion in adult mouse cochleae". PLOS ONE 18, n.º 12 (11 de diciembre de 2023): e0284685. http://dx.doi.org/10.1371/journal.pone.0284685.

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Regeneration of mammalian cochlear hair cells (HCs) by modulating molecular pathways or transcription factors is a promising approach to hearing restoration; however, immaturity of the regenerated HCs in vivo remains a major challenge. Here, we analyzed a single cell RNA sequencing (scRNA-seq) dataset during Atoh1-induced supporting cell (SC) to hair cell (HC) conversion in adult mouse cochleae (Yamashita et al. (2018)) using multiple high-throughput sequencing analytical tools (WGCNA, SCENIC, ARACNE, and VIPER). Instead of focusing on differentially expressed genes, we established independent expression modules and confirmed the existence of multiple conversion stages. Gene regulatory network (GRN) analysis uncovered previously unidentified key regulators, including Nhlh1, Lhx3, Barhl1 and Nfia, that guide converted HC differentiation. Comparison of the late-stage converted HCs with the scRNA-seq data from neonatal mouse cochleae (Kolla et al. (2020)) revealed that they closely resemble postnatal day 1 wild-type OHCs, in contrast to other developmental stages. Using ARACNE and VIPER, we discovered multiple key regulators likely to promote conversion to a more mature OHC-like state, including Zbtb20, Nfia, Zmiz1, Gm14418, Bhlhe40, Six2, Fosb and Klf9. Our findings provide insights into the regulation of HC regeneration in adult mammalian cochleae in vivo and demonstrate an approach for analyzing GRNs in large scRNA-seq datasets.
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14

Zhong, Chao, Zhenhuang Chen, Xiaocui Luo, Cuicui Wang, Hui Jiang, Jianzhong Shao, Minxin Guan, Liquan Huang, Xiao Huang y Jinfu Wang. "Corrigendum to “Barhl1 is required for the differentiation of inner ear hair cell-like cells from mouse embryonic stem cells” [Int. J. Biochem. Cell Biol. 96 (2018) 79–89]". International Journal of Biochemistry & Cell Biology 97 (abril de 2018): 128–29. http://dx.doi.org/10.1016/j.biocel.2018.02.009.

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15

Scholten, Frits. "'A Thing of Beauty is a Joy Forever’". Rijksmuseum Bulletin 66, n.º 3 (15 de septiembre de 2018): 254–69. http://dx.doi.org/10.52476/trb.9758.

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A somewhat neglected late fifteenth-century panel from the collection of the Amsterdam-Swiss surgeon and art collector Otto Lanz, which he cherished, is investigated here. This article argues persuasively that the panel is a devotional tabernacle, intended for private devotion, of a kind that often hung on the wall of a bedchamber in the late Middle Ages. The missing central image may have been a Virgin and Child or a Pietà. Lanz attributed the carving to the woodcarver Antonio di Neri Barili or Barile (1453-1516). Barile was the most important woodcarver in Siena, who worked for distinguished clients, among them the Piccolomini family, which was responsible for introducing the Roman all’antica style to Siena shortly after 1500. The tabernacle contains the family’s coat of arms and various motifs that correspond to documented work by Barili, and was carved in his characteristic crisp, open style. If this panel is indeed by Barili, it would be the smallest surviving object in its own right to come out of his workshop.
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16

Lum, G. y X. J. Min. "FunSecKB: the Fungal Secretome KnowledgeBase". Database 2011 (6 de febrero de 2011): bar001. http://dx.doi.org/10.1093/database/bar001.

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17

Blankenberg, D., N. Coraor, G. Von Kuster, J. Taylor y A. Nekrutenko. "Integrating diverse databases into an unified analysis framework: a Galaxy approach". Database 2011 (29 de abril de 2011): bar011. http://dx.doi.org/10.1093/database/bar011.

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18

Raju, R., L. Balakrishnan, V. Nanjappa, M. Bhattacharjee, D. Getnet, B. Muthusamy, J. Kurian Thomas et al. "A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway". Database 2011 (8 de julio de 2011): bar021. http://dx.doi.org/10.1093/database/bar021.

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19

Haw, R. A., D. Croft, C. K. Yung, N. Ndegwa, P. D'Eustachio, H. Hermjakob y L. D. Stein. "The Reactome BioMart". Database 2011 (19 de octubre de 2011): bar031. http://dx.doi.org/10.1093/database/bar031.

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20

Guberman, J. M., J. Ai, O. Arnaiz, J. Baran, A. Blake, R. Baldock, C. Chelala et al. "BioMart Central Portal: an open database network for the biological community". Database 2011 (18 de septiembre de 2011): bar041. http://dx.doi.org/10.1093/database/bar041.

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21

Jung, S., N. Menda, S. Redmond, R. M. Buels, M. Friesen, Y. Bendana, L. A. Sanderson et al. "The Chado Natural Diversity module: a new generic database schema for large-scale phenotyping and genotyping data". Database 2011 (26 de noviembre de 2011): bar051. http://dx.doi.org/10.1093/database/bar051.

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22

Brose, Michelle. "Barely Breathing". Narrative Inquiry in Bioethics 10, n.º 3 (2020): 202–5. http://dx.doi.org/10.1353/nib.2020.0057.

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23

Chesser, T., M. F. Gargan y K. M. Willett. "'Barfly' injuries." BMJ 305, n.º 6853 (5 de septiembre de 1992): 583. http://dx.doi.org/10.1136/bmj.305.6853.583-b.

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24

Compton, Tony. "Barely literate". New Scientist 210, n.º 2808 (abril de 2011): 31. http://dx.doi.org/10.1016/s0262-4079(11)60863-4.

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25

Maynard, Jake. "Barely Runnable". Appalachian Heritage 46, n.º 2 (2018): 48–59. http://dx.doi.org/10.1353/aph.2018.0004.

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26

Coylewright, Megan y Alexander M. Kowal. "Barely Contained". American Journal of Medicine 122, n.º 6 (junio de 2009): 525–27. http://dx.doi.org/10.1016/j.amjmed.2009.03.007.

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27

Anderson, D. "Barely the Moon". Iowa Journal of Literary Studies 10, n.º 1 (1989): 124. http://dx.doi.org/10.17077/0743-2747.1312.

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28

Peters, Tom. "Prometheus barely unbound". Academy of Management Perspectives 4, n.º 4 (abril de 1990): 70–84. http://dx.doi.org/10.5465/ame.1990.4277211.

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29

Fingerhut, L. A. "The Barell matrix". Injury Prevention 8, n.º 3 (1 de septiembre de 2002): 259. http://dx.doi.org/10.1136/ip.8.3.259.

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30

Magriel, Nicolas. "The Barhat Tree". Asian Music 28, n.º 2 (1997): 109. http://dx.doi.org/10.2307/834476.

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31

Sampson, Fred. "Managing, just barely". Interactions 14, n.º 1 (enero de 2007): 10–11. http://dx.doi.org/10.1145/1189976.1189986.

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32

Goodall, Christopher. "Managing, but barely coping". Nursing Standard 8, n.º 5 (20 de octubre de 1993): 51. http://dx.doi.org/10.7748/ns.8.5.51.s63.

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33

Holsti, Kal J., Jack Snyder y Robert Jervis. "Barely Coping with Complexity". Mershon International Studies Review 38, n.º 2 (octubre de 1994): 285. http://dx.doi.org/10.2307/222726.

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34

Black, Donald D. "The Barkly West Declaration". Baptist Quarterly 34, n.º 1 (enero de 1991): 43–45. http://dx.doi.org/10.1080/0005576x.1991.11751855.

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35

SENNETT, EDWARD J. "Fred C. Barald, MD". Radiology 181, n.º 2 (noviembre de 1991): 609. http://dx.doi.org/10.1148/radiology.181.2.609-a.

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36

Christie, Christina A. "Interview With Eric Barela". American Journal of Evaluation 29, n.º 4 (diciembre de 2008): 534–46. http://dx.doi.org/10.1177/1098214008328409.

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37

Currie, J. R. "Impossible Reconciliations (Barely Heard)". Music and Letters 88, n.º 1 (25 de octubre de 2006): 121–33. http://dx.doi.org/10.1093/ml/gcl075.

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38

Vinik, A. I. "Barely Scratching the Surface". Diabetes Care 33, n.º 1 (29 de diciembre de 2009): 210–12. http://dx.doi.org/10.2337/dc09-2035.

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39

Shampo, Marc A. y Robert A. Kyle. "Charles Barkla—Nobel Laureate". Mayo Clinic Proceedings 68, n.º 12 (diciembre de 1993): 1176. http://dx.doi.org/10.1016/s0025-6196(12)60068-8.

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40

Anagnostopoulou, Vlasia, Susmit Biswas, Heba Saadeldeen, Alan Savage, Ricardo Bianchini, Tao Yang, Diana Franklin y Frederic T. Chong. "Barely alive memory servers". ACM Journal on Emerging Technologies in Computing Systems 8, n.º 4 (octubre de 2012): 1–20. http://dx.doi.org/10.1145/2367736.2367742.

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41

Membrey, Conducted by Jill. "Interview with Peter Barham". Physics Education 35, n.º 2 (24 de febrero de 2000): 139–42. http://dx.doi.org/10.1088/0031-9120/35/2/312.

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42

Ophir, Adi. "A Barely Visible Protagonist". differences 26, n.º 2 (septiembre de 2015): 106–20. http://dx.doi.org/10.1215/10407391-3146009.

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43

Hogg, D. W. "A Barely Tested Hypothesis". Science 286, n.º 5445 (26 de noviembre de 1999): 1679b—1679. http://dx.doi.org/10.1126/science.286.5445.1679b.

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44

Stephens, Richard. "On barely continuous functions". International Journal of Mathematics and Mathematical Sciences 11, n.º 4 (1988): 695–99. http://dx.doi.org/10.1155/s0161171288000845.

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The term barely continuous is a topological generalization of Baire-1according toF. Gerlits of the Mathematical Institute of the Hungarian Academy of Sciences, and thus worthy of further study. This paper compares barely continuous functions and continuous functions on an elementary level. Knowing how the continuity of the identity function between topologies on a given set yields the lattice structure for those topologies, the barely continuity of the identity function between topologies on a given set is investigated and used to add to the structure of that lattice. Included are certain sublattices generated by the barely continuity of the identity function between those topologies. Much attention is given to topologies on finite sets.
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45

Kuzucuoğlu, M. "Barely transitive permutation groups". Archiv der Mathematik 55, n.º 6 (diciembre de 1990): 521–32. http://dx.doi.org/10.1007/bf01191686.

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46

Loudon, Michael F. "The 'Barely Veiled Warning'". JAMA: The Journal of the American Medical Association 259, n.º 7 (19 de febrero de 1988): 1019. http://dx.doi.org/10.1001/jama.1988.03720070023027.

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47

Loudon, M. F. "The 'barely veiled warning'". JAMA: The Journal of the American Medical Association 259, n.º 7 (19 de febrero de 1988): 1019–20. http://dx.doi.org/10.1001/jama.259.7.1019.

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48

Yamana, Shoji. "Sense of Guilt Barely Dodged:". International Journal of Human Culture Studies 2016, n.º 26 (2016): 551–71. http://dx.doi.org/10.9748/hcs.2016.551.

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49

Singh Patel, Anand. "FOLK ARTS OF BARELA TRIBE". International Journal of Research -GRANTHAALAYAH 7, n.º 11 (30 de noviembre de 2019): 165–71. http://dx.doi.org/10.29121/granthaalayah.v7.i11.2019.3730.

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Tribal traditional arts are associated with some rituals and festivals. The arts prevalent in the folk, which involve deep process and growth of rituals, are folk arts that should be made as demonstrators. The display has full potential. They should try to give a demonstrative look. आदिवासी पारम्परिक कलाएँ किसी न किसी अनुष्ठान और पर्व.उत्सव से जुड़ी रहती है।लोक में प्रचलित कलाएँ जिनमें अनुष्ठान की गहरी प्रक्रिया और वृद्धि निहित होती है ऐसी लोक कलाएँ जो प्रदर्शनकारी के रूप में बनायी जानी चाहिए।ऐसी विधाएँ जिनमें अनुष्ठान बहुत कम हैं जिनमें प्रदर्शन की पूरी क्षमता है। उन्हें ही प्रदर्शनकारी रूप देने का प्रयास करना चाहिए।
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50

Downey, Rod, Geoffrey Laforte y Steffen Lempp. "A set with barely degree". Journal of Symbolic Logic 64, n.º 4 (diciembre de 1999): 1700–1718. http://dx.doi.org/10.2307/2586807.

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