Artículos de revistas: "Article 1 du Protocole n° 12"

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Baltes, Paul B., Karl Ulrich Mayer, Hanfried Helmchen y Elisabeth Steinhagen-Thiessen. "The Berlin Aging Study (BASE): Overview and Design". Ageing and Society 13, n.º 4 (diciembre de 1993): 483–515. http://dx.doi.org/10.1017/s0144686x00001343.

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ABSTRACTThis article, the introduction to a collection of six related articles, describes the general rationale and design of the Berlin Aging Study (BASE). The distinguishing features of BASE are: (1) a special focus on the very old (70–105 years), (2) broad inter-diciplinarity (medicine, psychiatry, psychology, sociology and economics), and (3) sample heterogeneity achieved by local (West Berlin) representativeness. In addition to discipline-specific topics, four theoretical orientations guide the study: (1) differential ageing, (2) continuity versus discontinuity of ageing, (3) range and limits of plasticity and reserve capacity, and (4) ageing as an inter-disciplinary and systemic phenomenon. To provide a foundation and framework for the remaining articles, this paper outlines the protocols, designs, and measurement procedures of fourteen data collection sessions. In addition, information is given on the samples used for empirical analysis. Two samples from the first wave of the Berlin Aging Study are addressed in this collection of articles. The first (N = 360), uses data from the BASE Intake Assessment Protocol (Session 1). The second (N = 156), employs data from the entire 14-session full protocol of BASE. Selectivity analyses involving 22 comparison variables are reported in this paper and demonstrate that, with the exception of 12-month mortality, these two samples displayed the intended sample heterogeneity. Those results suggest that data from BASE hold high generalizability.

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Kolaczko, Jensen G., Derrick M. Knapik y Michael J. Salata. "Peri-operative pain management in hip arthroscopy: a systematic review of the literature". Journal of Hip Preservation Surgery 6, n.º 4 (7 de noviembre de 2019): 353–63. http://dx.doi.org/10.1093/jhps/hnz050.

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Abstract The purpose of this article was to review current literature on peri-operative pain management in hip arthroscopy. A systematic review of the literature on pain control in hip arthroscopy published January 2008 to December 2018 was performed. Inclusion criteria consisted of English language or articles with English translations, subjects undergoing hip arthroscopy with documented peri-operative pain control protocols in studies reporting Level I to IV evidence. Exclusion criteria were non-English articles, animal studies, prior systematic review or meta-analyses, studies not reporting peri-operative pain control protocols, studies documenting only pediatric (<18 years of age) patients, studies with Level V evidence and studies including less than five subjects. Statistical analysis was performed to assess pain protocols on narcotic consumption in PACU, VAS score on discharge, time to discharge from PACU and incidence of complications. Seventeen studies were included, comprising 1674 patients. Nerve blocks were administered in 50% of patients (n = 838 of 1674), of which 88% (n = 740 of 838) received a pre-operative block while 12% (n = 98 of 838) post-operative block. Sixty-eight complications were recorded: falls (54%, n = 37), peripheral neuritis (41%, n = 28), seizure (1.5%, n = 1), oxygen desaturation and nausea (1.5%, n = 1) and epidural spread resulting in urinary retention (1.5%, n = 1). No significant differences in narcotic consumption, VAS score at discharge, time until discharge or incidence of complication was found based on pain control modality utilized. No statistically significant difference in PACU narcotic utilization, VAS pain scores at discharge, time to discharge or incidence of complications was found between peri-operative pain regimens in hip arthroscopy.

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Moretti, Jean-Baptiste, Amélia Drouin, Caroline Truong, Elizabeth Youn, Anik Cloutier, Fernando Alvarez, Massimiliano Paganelli et al. "Effects of polyphenol supplementation on hepatic steatosis, intima-media thickness and non-invasive vascular elastography in obese adolescents: a pilot study protocol". BMJ Open 14, n.º 1 (enero de 2024): e074882. http://dx.doi.org/10.1136/bmjopen-2023-074882.

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IntroductionNon-alcoholic fatty liver disease (NAFLD) is increasingly prevalent in obese adolescents. Increased systemic inflammation and decreased gut microbial diversity linked to obesity affect the liver and are also associated with cardiovascular diseases in adulthood. However, NAFLD and vascular alterations are reversible.Methods and analysisThis pilot study evaluated the feasibility of a prospective open-label randomised controlled trial evaluating the effects of polyphenols on NAFLD and vascular parameters in obese adolescents. Children aged 12–18 years with hepatic steatosis (n=60) will be recruited. The participants will be randomised with a 1:1 allocation ratio to receive polyphenol supplementation one time per day for 8 weeks along with the clinician-prescribed treatment (group B, n=30) or to continue the prescribed treatment without taking any polyphenols (group A, n=30). The outcome measures will be collected from both the groups at day 1 before starting polyphenol supplementation, at day 60 after 8 weeks of supplementation and at day 120, that is, 60 days after supplementation. The changes in hepatic steatosis and vascular parameters will be measured using liver and vascular imaging. Furthermore, anthropometric measures, blood tests and stool samples for gut microbiome analysis will be collected. After evaluating the study’s feasibility, we hypothesise that, as a secondary outcome, compared with group A, the adolescents in group B will have improved NAFLD, vascular parameters, systemic inflammation and gut microbiome.Ethics and disseminationThis study is approved by Health Canada and the hospital ethics. Participants and their parents/tutors will both provide consent. Trial results will be communicated to the collaborating gastroenterologists who follow the enrolled participants. Abstracts and scientific articles will be submitted to high-impact radiological societies and journals. ClinicalTrials.gov ID:NCT03994029. Health Canada authorisation referral number: 250 811. Protocole version 13, 2 June 2023.Trial registration numberNCT03994029.

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Botta, Sergio Brossi, Adriana Bona Matos, Bruna Uglik Garbui y Andre Figueiredo Reis. "Comparison of Chemical Aging and Water Immersion Time on Durability of Resin-Dentin Interface produced by an Etch-and-Rinse Adhesive". Journal of Contemporary Dental Practice 13, n.º 4 (2012): 464–71. http://dx.doi.org/10.5005/jp-journals-10024-1170.

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ABSTRACT Aim The aim of this study was to analyze and compare the influence of short-term NaOCl-storage and long-term water storage on the microtensile bond strength (μTBS) of etch-andrinse adhesive system to human dentin. Materials and methods Thirty-six third human molars were randomly divided into 6 groups (n = 6) according to the aging protocol: G1 (water, 24 hours); G2 (water, 6 months); G3 (water, 12 months); G4 (10% sodium hypochlorite – NaOCl, 1 hour); G5 (10% NaOCl, 3 hours) and G6 (10% NaOCl, 5 hours). A two-step etch-and-rinse adhesive (Adper Single Bond 2) was applied according to the manufacturers¡¦ instructions. A composite (Filtek Z250) was applied in four horizontal increments and was individually cured. Specimens were cut following the microtensile test technique, submitted to the different aging protocols, and tested in tension. The fracture pattern was observed in a stereomicroscope (40× magnification) and in a scanning electron microscope. The μTBS data were analyzed by ANOVA and Tukey's test (α = 0.05). Results The effect of storage in 10% NaOCl for 1 or 3 hours was not significantly different from that of aging in distilled water (DW) for 6 or 12 months (p > 0.05). Beams immersed in DW for 24 hours and in 10% NaOCl for 5 hours showed the highest and lowest ìTBS values respectively. Conclusion The aging protocols negatively influenced dentin bond strength. Aging specimens in 10% NaOCl for 1 or 3 hours can be an alternative method for long-term water storage (6 or 12 months) bond strength studies. Clinical significance This aging protocol allows a quick achievement of longitudinal bond strength data, so that results are available to the professionals in this area while the materials are yet present at the dental market. How to cite this article Garbui BU, Botta SB, Reis AF, Matos AB. Comparison of Chemical Aging and Water Immersion Time on Durability of Resin-Dentin Interface produced by an Etchand- Rinse Adhesive. J Contemp Dent Pract 2012;13(4):464-471.

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Torres, Carlos Rocha Gomes, Eduardo Bresciani, César R. Pucci, Natália R. Barbosa, Karen CK Yui, Maria Filomena RL Huhtala y Daphne C. Barcellos. "Influence of Dentin Deproteinization on Bonding Degradation: 1-year Results". Journal of Contemporary Dental Practice 17, n.º 12 (2016): 985–89. http://dx.doi.org/10.5005/jp-journals-10024-1968.

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ABSTRACT Introduction The decalcification protocol of dentin surface with sodium hypochlorite removes the exposed collagen fibrils and could improve the longevity of the bonding interface. This study evaluated the influence of collagen removal with 10% sodium hypochlorite (10% NaOCl) on the longitudinal shear bond strength (SBS) of adhesives to dentin. Materials and methods Seventy-two extracted human molars were sectioned and the buccal and lingual surfaces were flattened and acid etched with 37% phosphoric acid for 15 seconds. The specimens were divided into six groups (n = 12 teeth – 24 sections), according to adhesive and collagen removal protocol: group 1: UNO Dentastic; group 2: Prime and Bond NT; group 3: Single Bond; group 4: 10% NaOCl + UNO Dentastic; group 5: 10% NaOCl + Prime and Bond NT; group 6: 10% NaOCl + Single Bond. Composite Z100 buildup was prepared, and the SBS test was assessed after 24 hours and 1 year. Data were submitted to three-way analysis of variance (ANOVA) and Tukey tests (p < 0.05). Results The mean values (MPa) were for 24 hours: G1: 22.45B; G2: 7.90DE; G3: 12.56CD; G4: 19.85BC; G5: 33.73A; G6: 20.77B; and for 1 year: G1: 2.43E; G2: 2.26E; G3: 4.3DE; G4: 18.79BC; G5: 26.49AB; G6: 22.73B. Conclusion Dentin deproteinization treatment with 10% NaOCI influenced the SBS compared with conventional treatment. The negative influence on SBS detected for conventional groups at 1-year interval was not detected for deproteinized groups. Clinical relevance The longevity of hybrid layer is critical due to the hydrolysis process at the adhesive interface over time. The use of 10% NaOCl deproteinization protocol might improve the longevity of bonding in adhesive restorations. How to cite this article Pucci CR, Barbosa NR, Bresciani E, Yui KCK, Huhtala MFRL, Barcellos DC, Torres CRG. Influence of Dentin Deproteinization on Bonding Degradation: 1-year Results. J Contemp Dent Pract 2016;17(12):985-989.

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Enu, Kirk B., Aude Zingraff-Hamed, Mohammad A. Rahman, Lindsay C. Stringer y Stephan Pauleit. "Review article: Potential of nature-based solutions to mitigate hydro-meteorological risks in sub-Saharan Africa". Natural Hazards and Earth System Sciences 23, n.º 2 (3 de febrero de 2023): 481–505. http://dx.doi.org/10.5194/nhess-23-481-2023.

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Abstract. Sub-Saharan Africa (SSA) is the region most vulnerable to climate change and related hydro-meteorological risks. These risks are exacerbated in rapidly expanding urban areas due to the loss and degradation of green and blue spaces with their regulating ecosystem services. The potential of nature-based solutions (NBSs) to mitigate hydro-meteorological risks such as floods is increasingly recognised in Europe. However, its application in urban areas of SSA still needs to be systematically explored to inform and promote its uptake in this region. We conducted a multidisciplinary systematic review following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol to establish the general patterns in the literature on NBSs and hydro-meteorological risk mitigation in SSA. We searched scientific journal databases, websites of 12 key institutions and 11 NBS databases and identified 45 papers for analysis. We found at least 1 reported NBS in 71 % of urban areas of SSA across 83 locations. Of the papers, 62 % were clustered in South Africa, Kenya, Tanzania and Nigeria only, while the most studied cities were Dar es Salaam and Kampala. Moreover, 66 NBS practices were identified, most of which (n=44) were for flood mitigation. With only Mozambique (n=2) among the most at-risk countries reporting NBSs, we found that NBSs are implemented where risks occur but not where they are most severe. Mangrove restoration (n=10) and wetland restoration (n=7), reforestation (n=10) and urban forests (n=8), and agroforestry (n=3) and conservation agriculture (n=2) were the most common NBS practices identified for floods, extreme-heat and drought mitigation, respectively. Traditional practices that fit the definition of NBSs, such as grass strips and stone bunds, and practices that are more popular in the Global North, such as green roofs and green façades, were also identified. These NBSs also provided ecosystem services, including 15 regulatory, 5 provisioning and 4 cultural ecosystem services, while 4 out of every 5 NBSs created livelihood opportunities. We conclude that the reported uptake of NBSs for hydro-meteorological risks in SSA is low. However, there could be more NBSs, especially at the local level, that are unreported. NBSs can help SSA address major development challenges such as water and food insecurity and unemployment and help the sub-region progress towards climate-resilient development. Therefore, we recommend that NBSs be mainstreamed into urban planning and knowledge exchange opportunities between SSA and Europe and that other regions be explored to promote uptake.

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Saeed, Ayesha, Catharine S. Bradley, Yashvi Verma y Simon P. Kelley. "Resolving residual acetabular dysplasia following successful brace treatment for developmental dysplasia of the hip in infants". Bone & Joint Journal 106-B, n.º 7 (1 de julio de 2024): 744–50. http://dx.doi.org/10.1302/0301-620x.106b7.bjj-2023-1169.r1.

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AimsRadiological residual acetabular dysplasia (RAD) has been reported in up to 30% of children who had successful brace treatment of infant developmental dysplasia of the hip (DDH). Predicting those who will resolve and those who may need corrective surgery is important to optimize follow-up protocols. In this study we have aimed to identify the prevalence and predictors of RAD at two years and five years post-bracing.MethodsThis was a single-centre, prospective longitudinal cohort study of infants with DDH managed using a published, standardized Pavlik harness protocol between January 2012 and December 2016. RAD was measured at two years’ mean follow-up using acetabular index-lateral edge (AI-L) and acetabular index-sourcil (AI-S), and at five years using AI-L, AI-S, centre-edge angle (CEA), and acetabular depth ratio (ADR). Each hip was classified based on published normative values for normal, borderline (1 to 2 standard deviations (SDs)), or dysplastic (> 2 SDs) based on sex, age, and laterality.ResultsOf 202 infants who completed the protocol, 181 (90%) had two and five years’ follow-up radiographs. At two years, in 304 initially pathological hips, the prevalence of RAD (dysplastic) was 10% and RAD (borderline) was 30%. At five years, RAD (dysplastic) decreased to 1% to 3% and RAD (borderline) decreased to < 1% to 2%. On logistic regression, no variables were predictive of RAD at two years. Only AI-L at two years was predictive of RAD at five years (p < 0.001). If both hips were normal at two years’ follow-up (n = 96), all remained normal at five years. In those with bilateral borderline hips at two years (n = 21), only two were borderline at five years, none were dysplastic. In those with either borderline-dysplastic or bilateral dysplasia at two years (n = 26), three (12%) were dysplastic at five years.ConclusionThe majority of patients with RAD at two years post-brace treatment, spontaneously resolved by five years. Therefore, children with normal radiographs at two years post-brace treatment can be discharged. Targeted follow-up for those with abnormal AI-L at two years will identify the few who may benefit from surgical correction at five years’ follow-up.Cite this article: Bone Joint J 2024;106-B(7):744–750.

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Kalinina, I. I., D. A. Venyov, Yu V. Olshanskaya, M. N. Sadovskaya, O. V. Goronkova, T. Yu Salimova, U. N. Petrova et al. "The outcomes of children with acute myeloid leukemia treated in accordance with the AML–MM-2006 protocol". Pediatric Hematology/Oncology and Immunopathology 21, n.º 1 (27 de marzo de 2022): 20–35. http://dx.doi.org/10.24287/1726-1708-2022-21-1-20-35.

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Over the past years, the outcomes of patients with acute myeloid leukemia (AML) have significantly improved due to the use of intensive chemotherapy, more effective supportive therapy, and the availability of allogeneic hematopoietic stem cell transplantation. This article presents the outcomes of children with AML treated in accordance with the AML-MM-2006 protocol. Our study was approved by the Independent Ethics Committee of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. The study included 233 patients with a median age of 6.5 years (7 days – 18 years) who were stratified into the following risk groups: standard risk, intermediate risk, and high risk. The 5-year event-free survival (EFS) was 0.64 ± 0,14, 0.49 ± 0.05, and 0.43 ± 0.05 for standard-risk (n = 12), intermediate-risk (n = 106), and high-risk (n = 115) patients, respectively (p = 0.14), while the 5-year overall survival (OS) was 1.0 year, 0.7 ± 0.05 and 0.55 ± 0.05, respectively (p = 0.001). The OS in the entire cohort was 0.68 ± 0.032. Factors associated with poor prognosis included hyperleukocytosis, the presence of extramedullary lesions, and age < 1 year. The overall survival rates in these patient groups were 0.55 ± 0.08, 0.39 ± 0.09 and 0.49 ± 0.08, respectively. The worst prognosis was for patients with monosomy 7 and t(7;12) whose OS rates were 0.25 ± 0.2 and 0.4 ± 0.2, respectively. For non-responders and patients with relapsed AML, the OS was 0.33 ± 0.08 and 0.54 ± 0.06, respectively. Early death (before remission could be achieved) occurred in 4% of patients, and 3.8% of patients died in first remission. Sixtytwo percent of deceased patients died of disease progression. In the entire cohort of patients, the five-year EFS was 0.53 ± 0.047, the cumulative risk of relapse after 3 years of remission was 40%, the confidence interval was 23–89%.

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Teasell, Robert W., J. Andrew McClure, David Walton, Jason Pretty, Katherine Salter, Matthew Meyer, Keith Sequeira y Barry Death. "A Research Synthesis of Therapeutic Interventions for Whiplash-Associated Disorder: Part 1 – Overview and Summary". Pain Research and Management 15, n.º 5 (2010): 287–94. http://dx.doi.org/10.1155/2010/106593.

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Whiplash-associated disorder (WAD) represents a significant public health problem, resulting in a substantial socioeconomic burden throughout the industrialized world, wherever costs are documented. While many treatments have been advocated for patients with WAD, scientific evidence of their effectiveness is often lacking. A systematic review was conducted to evaluate the strength of evidence supporting various WAD therapies. Multiple databases (including Web of Science, EMBASE and PubMed) were searched to identify all studies published from January 1980 through March 2009 that evaluated the effectiveness of any clearly defined treatment for acute (less than two weeks), subacute (two to 12 weeks) or chronic (longer than 12 weeks) WAD. The present article, the first in a five-part series, provides an overview of the review methodology as well as a summary and discussion of the review’s main findings. Eighty-three studies met the inclusion criteria, 40 of which were randomized controlled trials. The majority of studies (n=47) evaluated treatments initiated in the chronic stage of the disorder, while 23 evaluated treatments for acute WAD and 13 assessed therapies for subacute WAD. Exercise and mobilization programs for acute and chronic WAD had the strongest supporting evidence, although many questions remain regarding the relative effectiveness of various protocols. At present, there is insufficient evidence to support any treatment for subacute WAD. For patients with chronic WAD who do not respond to conventional treatments, it appears that radiofrequency neurotomy may be the most effective treatment option. The present review found a relatively weak but growing research base on which one could make recommendations for patients at any stage of the WAD continuum. Further research is needed to determine which treatments are most effective at reducing the disabling symptoms associated with WAD.

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Verhoeven, Els, Said Abdellati, Patrick Nys, Jolein Laumen, Irith De Baetselier, Tania Crucitti y Chris Kenyon. "Construction and optimization of a ‘NG Morbidostat’ - An automated continuous-culture device for studying the pathways towards antibiotic resistance in Neisseria gonorrhoeae". F1000Research 8 (26 de abril de 2019): 560. http://dx.doi.org/10.12688/f1000research.18861.1.

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To obtain a detailed picture of the dynamics of antibiotic resistance development in Neisseria gonorrhoeae, we built a morbidostat according to the protocol of Toprak et al., adjusted to the specific characteristics required for the growth of N. gonorrhoeae. In this article we describe the adaptations, specifications and the difficulties we encountered during the construction and optimization of the NG morbidostat. As a proof of concept, we conducted a morbidostat experiment by increasing concentrations of azithromycin in response to bacterial growth. We started the experiment with two N. gonorrhoeae reference strains WHO-F and WHO-X. These strains were grown in 12 mL GC Broth supplemented with IsoVitaleX™ (1%) and vancomycin, colistin, nystatin, trimethoprim (VCNT) selective supplement for 30 days in a 6% CO2 environment at 36°C. Samples of the cultures were taken 2-3 times a week and minimal inhibitory concentrations (MICs) of azithromycin were determined using E-test. The initial MICs of WHO-F and WHO-X were 0.125 µg/mL and 0.25 µg/mL, respectively. In less than 30 days, we were able to induce high level azithromycin resistance in N. gonorrhoeae, with a 750 and 1000 fold increase in MIC for WHO-F and WHO-X, respectively.

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Verhoeven, Els, Said Abdellati, Patrick Nys, Jolein Laumen, Irith De Baetselier, Tania Crucitti y Chris Kenyon. "Construction and optimization of a ‘NG Morbidostat’ - An automated continuous-culture device for studying the pathways towards antibiotic resistance in Neisseria gonorrhoeae". F1000Research 8 (8 de enero de 2020): 560. http://dx.doi.org/10.12688/f1000research.18861.2.

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To obtain a detailed picture of the dynamics of antibiotic resistance development in Neisseria gonorrhoeae, we built a morbidostat according to the protocol of Toprak et al., adjusted to the specific characteristics required for the growth of N. gonorrhoeae. In this article we describe the adaptations, specifications and the difficulties we encountered during the construction and optimization of the NG morbidostat. As a proof of concept, we conducted a morbidostat experiment by increasing concentrations of azithromycin in response to bacterial growth. We started the experiment with two N. gonorrhoeae reference strains WHO-F and WHO-X. These strains were grown in 12 mL GC Broth supplemented with IsoVitaleX™ (1%) and vancomycin, colistin, nystatin, trimethoprim (VCNT) selective supplement for 30 days in a 6% CO2 environment at 36°C. Samples of the cultures were taken 2-3 times a week and minimal inhibitory concentrations (MICs) of azithromycin were determined using E-test. The initial MICs of WHO-F and WHO-X were 0.125 µg/mL and 0.25 µg/mL, respectively. In less than 30 days, we were able to induce high level azithromycin resistance in N. gonorrhoeae, with a 750 and 1000 fold increase in MIC for WHO-F and WHO-X, respectively.

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Sanders, Fay R. K., Merel F. Birnie, Siem A. Dingemans, Michel P. J. van den Bekerom, Markus Parkkinen, Ruben N. van Veen, J. Carel Goslings y Tim Schepers. "Functional outcome of routine versus on-demand removal of the syndesmotic screw: a multicentre randomized controlled trial". Bone & Joint Journal 103-B, n.º 11 (1 de noviembre de 2021): 1709–16. http://dx.doi.org/10.1302/0301-620x.103b11.bjj-2021-0348.r2.

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Aims The aim of this study was to investigate whether on-demand removal (ODR) is noninferior to routine removal (RR) of syndesmotic screws regarding functional outcome. Methods Adult patients (aged above 17 years) with traumatic syndesmotic injury, surgically treated within 14 days of trauma using one or two syndesmotic screws, were eligible (n = 490) for inclusion in this randomized controlled noninferiority trial. A total of 197 patients were randomized for either ODR (retaining the syndesmotic screw unless there were complaints warranting removal) or RR (screw removed at eight to 12 weeks after syndesmotic fixation), of whom 152 completed the study. The primary outcome was functional outcome at 12 months after screw placement, measured by the Olerud-Molander Ankle Score (OMAS). Results There were 152 patients included in final analysis (RR = 73; ODR = 79). Of these, 59.2% were male (n = 90), and the mean age was 46.9 years (SD 14.6). Median OMAS at 12 months after syndesmotic fixation was 85 (interquartile range (IQR) 60 to 95) for RR and 80 (IQR 65 to 100) for ODR. The noninferiority test indicated that the observed effect size was significantly within the equivalent bounds of -10 and 10 scale points (p < 0.001) for both the intention-to-treat and per-protocol, meaning that ODR was not inferior to RR. There were significantly more complications in the RR group (12/73) than in the ODR group (1/79) (p = 0.007). Conclusion ODR of the syndesmotic screw is not inferior to routine removal when it comes to functional outcome. Combined with the high complication rate of screw removal, this offers a strong argument to adopt on demand removal as standard practice of care after syndesmotic screw fixation. Cite this article: Bone Joint J 2021;103-B(11):1709–1716.

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John, Jithin, Rohun Gupta, Anne Grossbauer, Michael Chung, Anita Sethna, Michel Abboud, Eric Cox, Justin Hart, Adam Folbe y Kongkrit Chaiyasate. "Outcomes Associated with Nasal Reconstruction Post-Rhinectomy: A Narrative Review". Archives of Plastic Surgery 49, n.º 02 (marzo de 2022): 184–94. http://dx.doi.org/10.1055/s-0042-1744426.

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AbstractThe face and the external nose define an individual's physical appearance. Nasal deformities can cause facial disfigurement along with unwanted psychological repercussions. Nasal deformities range in severity, with the most severe cases being indications for a rhinectomy, due to the complexity of the nasal defect. According to published literature, there is no consensus among otolaryngologists and plastic surgeons on which technique or flap use is preferred in terms of complications, aesthetic outcome, or patient satisfaction. The goal of this study is to provide a comprehensive analysis of published studies on nasal reconstruction following rhinectomy. Using the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines for writing systematic reviews, a systematic review was conducted. Four databases were searched using a search strategy. These articles were then imported into the COVIDENCE software and went screening and thorough article review. After screening 2,237 articles, 23 studies were then extracted for data collection analysis. We collected data from 12 case series, 4 case studies, 1 prospective case series, and 4 retrospective chart review studies. The most commonly reported flaps were forehead flaps, superior extended nasal myocutaneous island, forearm free flaps, anterolateral thigh (ALT) free flap, medial femoral condyle free flap (n = 8), and zygomaticus implants (n = 6), and retained nasal prosthesis. Although not specifically indicated by a certain number, the most common indication for the rhinectomy was malignancy, followed by traumas, postsurgical complications, radionecrosis, and congenital nasal malformations.Although several donor flaps can be used after rhinectomy, we conclude that there is no preference over what flap has superior patient outcomes after analysis. As of current, there are no prospective studies that exist. Therefore, more research is necessary to determine the results of each flap.

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Chernyavskiy, A. M., M. M. Lyashenko, D. A. Sirota, A. A. Shadanov, B. N. Kozlov, D. S. Panfilov y E. V. Skurikhina. "False lumen thrombosis and aneurysmal transformation of the non-operated aorta after surgical treatment of proximal dissection". Patologiya krovoobrashcheniya i kardiokhirurgiya 27, n.º 3 (29 de septiembre de 2023): 19–30. http://dx.doi.org/10.21688/1681-3472-2023-3-19-30.

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Background: One of the most feared long-term complications of surgical treatment of proximal aortic dissections is an aneurysm of the non-operated compartments of the aorta.Objective: To conduct a comparative analysis of different methods for surgical treatment of proximal aortic dissections in relation to false lumen thrombosis development in non-operated compartments.Methods: We conducted a simple observational retrospective multicenter study to study the effectiveness of the frozen elephant trunk technique compared with a standard surgical intervention (aggressive hemiarch anastomosis or total aortic arch replacement with a multibranched prosthesis). Our study included 101 patients grouped based on the method of treatment: group 1 for frozen elephant trunk (n = 31); group 2 for thoracic aorta reconstruction by the standard methods (control group, n = 70). Due to the retrospective nature of the study and the disparity of groups by certain characteristics, we used propensity score matching to increase the reliability of the results. All patient data were collected in the preoperative period, from the protocols of surgical interventions, in the postoperative and long-term periods (3-6 months, 1 year, 2 years, 3 years after surgery). All statistical calculations were conducted in the RStudio software, version 0.99.879 (RStudio Inc., Boston, USA).Results: The absence of false lumen thrombosis at the thoracic aorta level persisted after the surgical treatment in half of the patients in the control group (n = 13; 52%) and was not determined in the frozen elephant trunk group. Complete false lumen thrombosis at the thoracic aorta level (level of stent graft placement and distal to the diaphragm) was achieved in more than half of the patients in the frozen elephant trunk group and only in 3 (12%) control patients. Aneurysmal transformation of the non-operated aorta occurred in 12 (48%) patients from group 2 and was absent in group 1.Conclusion: The frozen elephant trunk technique reduces the frequency of aorto-related events to 0% within 3 years compared with the standard approach (32%, P < .005). Patients operated on for proximal aortic dissection using the frozen elephant trunk technique are significantly more likely to have false lumen thrombosis in the thoracic aorta (P = .004), significantly lower incidence of aneurysmal transformation or thoracic aorta growth rate of >5 mm per year in the long-term period (P = .016) compared with those who underwent the standard methods. Received 15 February 2023. Revised 31 July 2023. Accepted 4 August 2023. Funding: The study was carried out within the framework of the grant of the President of the Russian Federation НШ-5096.2022.3 (agreement No. 075-15-2022-823 dated 12.05.2022). Conflict of interest: The authors declare no conflict of interest. Contribution of the authorsConception and study design: A.M. Chernyavskiy, M.M. Lyashenko Data collection and analysis: M.M. Lyashenko, A.A. Shadanov, D.S. Panfilov, E.V. SkurikhinaStatistical analysis: M.M. LyashenkoDrafting the article: M.M. LyashenkoCritical revision of the article: A.M. Chernyavskiy, D.A. Sirota, B.N. KozlovFinal approval of the version to be published: A.M. Chernyavskiy, M.M. Lyashenko, D.A. Sirota, A.A. Shadanov, B.N. Kozlov, D.S. Panfilov, E.V. Skurikhina

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Al-Nahlawi, Talal, Talaat Abo Hatab, Mahmoud Abd Alrazak y Ahmad Al-Abdullah. "Effect of Intracanal Cryotherapy and Negative Irrigation Technique on Postendodontic Pain". Journal of Contemporary Dental Practice 17, n.º 12 (2016): 990–96. http://dx.doi.org/10.5005/jp-journals-10024-1969.

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ABSTRACT Aim To evaluate the effect of intracanal cryotherapy with negative pressure irrigation (EndoVac) on postendodontic pain after vital single-visit root canal treatment (RCT). Materials and methods A total of 75 single-rooted teeth with single root canal were treated endodontically. After root canal preparation with Protaper Universal rotary system and irrigation, teeth were divided randomly into three groups (n = 25) according to additional irrigation protocol as follows: Group I: No additional irrigation was applied (control); group II: A 20 mL of room temperature saline was irrigated during 5 minutes using EndoVac, and group III: A 20 mL of 2 to 4°C cold saline was irrigated during 5 minutes using EndoVac. Pain levels were assessed by visual analog scale (VAS) and verbal evaluation of pain questionnaire after 6, 12, 24, 48 hours, and 7 days of canal obturation. The data were then analyzed using Statistical Package for the Social Sciences (SPSS) 13.0 using Kruskal–Wallis and Mann–Whitney U tests at p-value of 0.05. Results The results showed that pain levels were high in groups I and II after 6 hours that decreased with time to almost diminish after 1 week, and on the other hand, group III showed no pain among different monitoring periods. Also pain levels in groups II were lower compared with group I after only 6 hours, with significance p < 0.05. Conclusion Postendodontic pain presented with highest values after 6 hours of treatment and reduced to almost nil after 1 week. Intracanal cryotherapy eliminated postendodontic pain clinically. Negative pressure reduced postendodontic pain after 6 hours of treatment. Clinical significance The outcome of this study indicates that the use of intracanal cryotherapy technique with negative pressure irrigation eliminates postendodontic pain after single-visit RCTs. How to cite this article Al-Nahlawi T, Abo Hatab T, Abd Alrazak M, Al-Abdullah A. Effect of Intracanal Cryotherapy and Negative Irrigation Technique on Postendodontic Pain. J Contemp Dent Pract 2016;17(12):990-996.

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Konokh, A. y A. Vorontsov. "DEFINITION OF GENDER IDENTITY IN YOUNGER AGE GROUPS OF WOMEN'S BOXING". Scientific Journal of National Pedagogical Dragomanov University. Series 15. Scientific and pedagogical problems of physical culture (physical culture and sports), n.º 7(138) (27 de julio de 2021): 7–10. http://dx.doi.org/10.31392/npu-nc.series15.2021.7(138).01.

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The article considers the means of determining gender identification of girls engaged in boxing and their impact on the training and competitive process. Purpose: to determine gender identification of qualified girls boxers. Material & Methods: the study involved qualified (participants, prize-winners, champions of local tournaments and championships of Ukraine in their age group) girls boxers 12-15 years old, who are engaged in the city children's and youth sports school. A total of 10 girls were interviewed, including 7 athletes aged 15 and 3 athletes aged 12 years, sports experience at the time of the study ranged from 3 to 5 years. Research methods used: S. Bem's method "masculinity - femininity"; Freiburg Personal Questionnaire (FPI) Masculinity Scale; analysis and generalization of literary sources; analysis of excerpts from the protocols of competitions and video viewing of semifinal, final matches of two championships of Ukraine; method of mathematical statistics. Results: it was determined that most girls (n = 9) with index values (IS) in the range from -0,348 (± 0.05) to 0,580 (± 0.05) belong to the androgynous type according to the S.Bem classification. Only one athlete (n = 1) with indicators (IS) -1,276 belongs to the masculine type according to the classification of S. Bem. Determination of masculinity signs using the FPI test showed the number of points scored from 4 (± 2) to 9 out of 14 possible. Conclusions: The study proved the dominance of androgynous and masculine types in various sports in general. The ratio of gender types between individuals engaged in martial arts and boxing is revealed. The data on the dominance of the androgenic type of personality in the younger age groups of women's boxing have been supplemented. For more productive training of gender types of physical and special boxing exercises and forecasting of competitive activity, it is necessary to study individual psychological qualities of a girl-boxer. It is advisable in the subsequent stages of long-term training to conduct repeated tests of girls boxers of this research group in order to determine the progress of masculinization by age and sports experience and sports qualifications.

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Khan, Shehzaad A., Peter Logan, Ajay Asokan, Charles Handford, Harshadkumar Dhirajlal Rajgor, Nikhil Aravind Khadabadi, Thomas Moores y John Targett. "The incidence of venous thromboembolism in total joint replacement during COVID-19 pandemic". Bone & Joint Open 1, n.º 12 (1 de diciembre de 2020): 751–56. http://dx.doi.org/10.1302/2633-1462.112.bjo-2020-0144.r1.

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Aims As the first wave of the COVID-19 pandemic began to dip, restarting elective orthopaedics became a challenge. Protocols including surgery at ‘green’ sites, self-isolation for 14 days, and COVID-19 testing were developed to minimize the risk of transmission. In this study, we look at risk effects of 14-day self-isolation on the incidence of venous thromboembolism (VTE) in our green site hospital among patients undergoing total joint replacement (TJR). Methods This retrospective cohort study included 50 patients who underwent TJR. Basic demographic data was collected including, age, sex, American Society of Anesthesiologists (ASA) grade, body mass index (BMI), type of surgery, and complications at two and four weeks. Univariate and multivariate analysis were used to identify risk factors associated with an increased risk of VTE. Results A total of 50 patients were included in our study, with 24 males and 26 females. The mean age was 67.86 (SD 11.803). Overall, 8% of patients suffered a VTE complication; symptomatic non-fatal pulmoary embolism was confirmed in 6% of patients (n = 3) as an inpatient, and symptomatic deep vein thrombosis was diagnosed in 2% of patients (n = 1) within two weeks of their operation. All patients were found to be female (p < 0.001), had a BMI > 30 (p = 0.317), and were immobile prior to their operation using walking aids (p = 0.016). Conclusion The incidence we report is much higher than the reported incidence in the literature, which we believe is related to the 14-day self-isolation period and immobility prior to their operation. We recommend that all patients undergoing TJR that require a period of self-isolation, are pre-assessed prior to self-isolation for their risk of VTE, potentially using mechanical and chemical prophylaxis to reduce the likelihood of developing VTE. Cite this article: Bone Jt Open 2020;1-12:751–756.

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Prokhorikhin, A. A., V. I. Baystrukov, I. O. Grazhdankin, D. N. Ponomarev, V. V. Verin, A. G. Osiev, V. I. Ganyukov et al. "Prospective rAndomized, single-blind, mulTicenter study of sirolimus-eluting coRonary stent “Calypso” vs everolimus-eluting cOronary stenT “XiencePrime”: results of the PATRIOT trial". Patologiya krovoobrashcheniya i kardiokhirurgiya 21, n.º 3 (22 de noviembre de 2017): 76. http://dx.doi.org/10.21688/1681-3472-2017-3-76-85.

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Aim. This trial was aimed at comparing the efficacy and safety of sirolimus-eluting coronary stent “Calypso” (Angioline) and everolimus-eluting coronary stent “XiencePrime” (Abbott Vascular) when used for treatment of ischemic heart disease patients. Methods. The trial included patients suitable for coronary revascularization with coronary stenting. They underwent a standard revascularization procedure and were randomized in 2:1 ratio to receive “Calypso” coronary stent (Angioline) (n = 407) or “XiencePrime” coronary stent (AbbottVascular) (n = 203). The follow-up period was 12 months. In order to detect restenosis (secondary endpoint), angiographic follow-up was performed in 20% of cases at 12 months. The trial protocol had no limitations regarding the length of lesions, number of target lesions and number of implanted stents. The main exclusion criterion was STEMI. The composite primary endpoint included one-year target lesion-related complications determined as cardiogenic death, target vessel myocardial infarction, clinically indicated target lesion revascularization. The primary endpoint data were evaluated by an independent committee. Results. In the trial, 55% of patients had acute coronary syndrome with ST elevation and type C lesions were detected in 46% of cases. In “Calypso” and “XiencePrime” groups, TLF occurred in 5.4% and 6.4% respectively (absolute risk difference in TLF accounted for 1%, 95% CI [---;2.1%]; p non-inferiority = 0.017). Thus, the hypothesis of non-inferiority of “Calypso” as compared to “XiencePrime” was confirmed. The incidence of stent thrombosis (definite and probable) was relatively low and had no significant differences between “Calypso” and “XiencePrime” groups (0.73% and 0%; p>0.05). Definite stent thrombosis was noted in two cases in the “Calypso” group (0.49%), in one case the cause of thrombosis turned out to be incomplete stent expansion after implantation. Conclusion. “Calypso” sirolimus eluting stent was not inferior to “XiencePrime” everolimus-eluting stent in treating patients with coronary heart disease.Received 7 November 2017. Revised 13 November 2017. Accepted 20 November 2017.Funding: The study was funded by “Angioline Interventional Devices” (Novosibirsk, Russian Federation). The supporting source had no involvement in study design; collection, analysis and interpretation of data; writing of the report; and in the decision to submit the article for publication.Conflict of interest: The authors declare no conflict of interest.

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Younes, Ronald, Antoine Berberi, Nabih Nader, Maissa Aboulhosn y Cordahi Manal. "Marginal Bone Remodeling around healing Abutment vs Final Abutment Placement at Second Stage Implant Surgery: A 12-month Randomized Clinical Trial". Journal of Contemporary Dental Practice 17, n.º 1 (enero de 2016): 7–15. http://dx.doi.org/10.5005/jp-journals-10024-1795.

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ABSTRACT Background The periimplant bone level has been used as one of the criteria to assess the success of dental implants. It has been documented that the bone supporting two-piece implants undergoes resorption first following the second-stage surgery and later on further to abutment connection and delivery of the final prosthesis. Objective The aim of this multicentric randomized clinical trial was to evaluate the crestal bone resorption around internal connection dental implants using a new surgical protocol that aims to respect the biological distance, relying on the benefit of a friction fit connection abutment (test group) compared with implants receiving conventional healing abutments at secondstage surgery (control group). Materials and methods A total of partially edentulous patients were consecutively treated at two private clinics, with two adjacent two-stage implants. Three months after the first surgery, one of the implants was randomly allocated to the control group and was uncovered using a healing abutment, while the other implant received a standard final abutment and was seated and tightened to 30 Ncm. At each step of the prosthetic try-in, the abutment in the test group was removed and then retightened to 30 Ncm. Horizontal bone changes were assessed using periapical radiographs immediately after implant placement and at 3 (second-stage surgery), 6, 9 and 12 months follow-up examinations. Results At 12 months follow-up, no implant failure was reported in both groups. In the control group, the mean periimplant bone resorption was 0.249 ± 0.362 at M3, 0.773 ± 0.413 at M6, 0.904 ± 0.36 at M9 and 1.047 ± 0.395 at M12. The test group revealed a statistically significant lower marginal bone loss of 20.88% at M3 (0.197 ± 0.262), 22.25% at M6 (0.601 ± 0.386), 24.23% at M9 (0.685 ± 0.341) and 19.2% at M9 (0.846 ± 0.454). The results revealed that bone loss increased over time, with the greatest change in bone loss occurring between 3 and 6 months. Alveolar bone loss was significantly greater in the control condition than the test condition. Conclusion The results of this prospective study demonstrated the benefit of placing a prosthetic component with a stable connection at second-stage surgery, in terms of reduced marginal bone remodeling when compared with conventional procedure. Clinical significance. The use of a stable connection in a healing component during try-in stages prior to final restoration placement leads to less periimplant marginal bone loss. How to cite this article Nader N, Aboulhosn M, Berberi A, Manal C, Younes R. Marginal Bone Remodeling around healing Abutment vs Final Abutment Placement at Second Stage Surgery: A 12-month Randomized Clinical Trial. J Contemp Dent Pract 2016;17(1):7-15.

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Refvik, Mitchell D. y Adrian L. Schwan. "Article". Canadian Journal of Chemistry 76, n.º 2 (1 de febrero de 1998): 213–20. http://dx.doi.org/10.1139/v97-228.

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Lithium (E)-1-hexenesulfenate (5a) was treated with a number of TMS-X (TMS = trimethylsilyl) reagents to afford N,N-bis(trimethylsilyl)-(E)-1-hexenesulfenamide (7a) and (or) di((E)-1 hexenyl) disulfide (8), usually in low yield. The cleanest reactions, those from use of TMS-Cl (to afford 7a) and TMS-CN (which yields 8) were analyzed by variable temperature NMR. It was found that the low-temperature silylation reaction using TMS-Cl affords 7a and thiosulfinate 12 as initial products. Warming the mixture coerces the decomposition of 12. Treatment of 5a with TMS-CN also yields thiosulfinate 12 which is reduced to disulfide 8 as the temperature warms, possibly by action of cyanide ion. Evidence is presented that allows a confident structural assignment of the transient thiosulfinate 12, and mechanisms are suggested for the formation of 12. The study also led to the NMR observation of (E)-1-hexenesulfenate (5a).Key words: sulfenate, thiosulfinate, variable temperature NMR (VT NMR), silylation.

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Marsac, Fabrice y Witold Ucherek. "De perceptione : du protocole Ucherek 1982 à un grand corpus étiqueté bilingue 2022". Studia Romanica Posnaniensia 49, n.º 4 (9 de enero de 2023): 75–88. http://dx.doi.org/10.14746/strop.2022.494.005.

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This paper is made in continuation of the article of Fabrice Marsac, Witold Ucherek and Magdalena Dańko “De l’infinitive de perception dans la pratique traductologique” (Studia Romanica Posnaniensia 46/1, 2019); both papers fall within the framework of the bilateral Polonium program “On the translation of French perception structures into Polish” (n° PPN/BIL/2018/1/00181), implemented and financed by the Polish National Agency for Academic Exchange (NAWA), the French Ministry for Europe and Foreign Affairs (MEAE) and the Ministry of Higher Education, Research and Innovation (MESRI). In the present case, we intend to report on the content and progress of the part “multi-dimensional labelling” of this long-term French-Polish project. Therefore, we describe the formal encoding of structures, categories and functions of the items in the large multi-label corpus (French-Polish) we have been collecting since 2019.

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Laurens, Mara L. Leimanis, Chana Kraus-Friedberg, Wreeti Kar, Dominic Sanfilippo, Surender Rajasekaran y Sarah S. Comstock. "Dietary Intake Influences Metabolites in Healthy Infants: A Scoping Review". Nutrients 12, n.º 7 (13 de julio de 2020): 2073. http://dx.doi.org/10.3390/nu12072073.

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Metabolites are generated from exogenous sources such as diet. This scoping review will summarize nascent metabolite literature and discriminating metabolites for formula vs. human- milk-fed infants. Using the PICOS framework (P—Patient, Problem or Population; I—Intervention; C—Comparison; O—Outcome; S—Study Design) and PRISMA item-reporting protocols, infants less than 12 months old, full-term, and previously healthy were included. Protocol was registered with Open Science Framework (OSF). Publications from 1 January 2009–2019 were selected, for various biofluids, study designs, and techniques (such as high-performance liquid chromatography (HPLC)). From 711 articles, blinded screening of 214 articles using Abstrackr® software, resulted in 24 for final review. Strengthening the Reporting of Observational studies in Epidemiology (STROBE) guidelines were adopted, which included a 24-point checklist. Articles were stratified according to biofluid. Of articles reporting discriminating metabolites between formula- and human milk-fed infants, 62.5% (5/8) of plasma/serum/dried blood spot, 88% (7/8) of urine and 100% (6/6) of feces related articles reported such discriminating metabolites. Overall, no differences were found between analytical approach used (targeted (n = 9) vs. un-targeted (n = 10)). Current articles are limited by small sample sizes and differing methodological approaches. Of the metabolites reviewed herein, fecal metabolites provided the greatest distinction between diets, which may be indicative of usefulness for future diet metabolite-focused work.

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Lestari, Mega Cahya Dwi, Ayu Citra Dewi, Sri Intan Wahyuni, Juliwis Kardi, Yendri Junaidi y Alif Laini. "Implementation of Stimulation, Early Detection, and Intervention Programs for Monitoring the Growth and Development of Children Aged 2-3 Years". JPUD - Jurnal Pendidikan Usia Dini 18, n.º 1 (30 de abril de 2024): 183–94. http://dx.doi.org/10.21009/jpud.181.13.

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Starting from growth that supports development, in the end growth and development go hand in hand. An important period in a child's growth and development begins in infancy because basic growth is what will influence and determine the child's subsequent development. The aim of this research is to detect deviations in the development of early childhood children aged 2-3 years at the ECCE Rahmah El Yunusiyyah Padang Panjang through the Stimulation, Detection and Early Intervention of Child Growth and Development (SDICGD) instruments in the Android feature. This research was conducted using a cross-sectional approach. Participants in this study were 26 children aged 2-3 years using a consecutive sampling technique of 10 children whose growth and development were monitored using the SDICGD android application. The results of this study showed that several partisipants experienced malnutrition, one partisipant out of nine normal partisipants. The Developmental Pre-Screening Questionnaire (DPSQ) instrument of the ten child participants contained nine children (90%) who were according to the developmental stage aged 24-36 months, and one child was not according to the developmental stage. The results of the Attention Deficit and Hyperactivity Disorder (ADHD) test showed that three children (60%) were normal, and two children (40%) were hyperactive. Early detection of children's growth and development must be carried out regularly every month, and according to the child's age. For further research, it is hoped that early detection will also be carried out on the development of children's mental health, not just growth and development which is common and widely researched. Schools and parents must play an active role in children's growth and development so that no developmental stages are missed, and children grow and develop according to their age. Keywords: simulation, detection, early intervention, child growth and development, development of children aged 2-3 years References: Arinny, L. (2023). Deteksi Dini Masalah Perilaku Psikososial Pada Remaja Di Sekolah Menengah Atas Kota Semarang. Jurnal Keperawatan Jiwa (JKJ): Persatuan Perawat Nasional Indonesia, 12(1), 67–74. https://stikes-nhm.e-journal.id/NU/article/view/1749 Dunkel, Luque, Loche, & Savage. (2021) ‘Digital technologies to improve the precision of pediatric growth disorder diagnosis and management’, Growth Hormone and IGF Research, 59, p. 101408. https://doi.org/10.1016/j.ghir.2021.101408. Endo, D. (2014). Monitoring the Growth and Development of Toddlers Using Ma-ternal and Child Health Book. Kesmasindo, Volume 6 N, 166–175. Fitriani, I. S., & Oktobriariani, R. R. (2017). Stimulasi, Deteksi dan Intervensi Dini Orang Tua terhadap Pencegahan Penyimpangan Pertumbuhan dan Perkembangan Anak Balita. Indonesian Journal for Health Sciences, 1(1), 1. https://doi.org/10.24269/ijhs.v1i1.383 Friska, E. and Andriani, H. (2022) ‘The Utilization of Android-Based Application as a Stunting Prevention E-Counseling Program Innovation during Covid-19 Pandemic’, Journal of Maternal and Child Health, 6(5), pp. 323–332. https://doi.org/10.26911/thejmch.2021.06.05.02. González-Pérez, Matey-Sanz, Granell, Díaz-Sanahuja, Bretón-López, & Casteleyn. (2023) ‘AwarNS: A framework for developing context-aware reactive mobile applications for health and mental health’, Journal of Biomedical Informatics, 141(October 2022), p.104359. https://doi.org/10.1016/j.jbi.2023.104359. Gusvita, Y. (2024). Program PAUD Rahmah El Yunusiyyah. Hibana, H., & Surahman, S. (2021). Optimalisasi Perkembangan Anak Melalui Deteksi Dini Tumbuh Kembang Anak. Qurroti : Jurnal Pendidikan Islam Anak Usia Dini, 3(1), 42–55. https://doi.org/10.36768/qurroti.v3i1.150 IDAI. (2013). Recognizing Common Developmental Delays in Children. http://www.idai.or.id/article/seputar-kesehatan-anak/mengenal-keterlamatan-perkembangan-umum-pada-anak Inggriani, D. M. (2019). “Early Detection of Growth and Development of Children Aged 0-6 Years Based on Android Applications.” STIKES Adila Journal, Volume 1,. Inggriani, D. M., Rinjani, M., & Susanti, R. (2019). Deteksi Dini Tumbuh Kembang Anak Usia 0-6 Tahun Berbasis Aplikasi Android. Wellness And Healthy Magazine, 1(1), 115–124. https://wellness.journalpress.id/wellness/article/download/w1117/65 Kozhevnikov, M. (2007). Cognitive Styles in the Context of Modern Psychology: Toward an Integrated Framework of Cognitive Style. Psychological Bulletin, 133(3), 464–481. https://doi.org/10.1037/0033-2909.133.3.464 Kozier, Erb, Berman, & S. (2015). Nursing Fundamentals Textbook: Concepts, Processes, Practices .: Vol. (7th ed.,. EGC. Langarizadeh, M. et al. (2021) ‘Mobile apps for weight management in children and adolescents; An updated systematic review’, Patient Education and Counseling, 104(9), pp. 2181–2188. https://doi.org/10.1016/j.pec.2021.01.035. Mahyumi Rantina, Dra. Rahmanela, Y. K. N. (2021). Buku Stimulasi Dan Deteksi Dini Tumbuh Kembang Anak (0-6Tahun). EDU Publisher. https://books.google.co.id/books?id=raEJEAAAQBAJ&lpg=PP3&pg=PP1#v=onepage&q&f=false Marwasariaty, M., Sutini, T., & Sulaeman, S. (2019). Pendidikan Kesehatan Menggunakan Media Booklet + Aplikasi SDIDTK Efektif Meningkatkan Kemandirian Keluarga dalam Pemantauan Tumbuh Kembang Balita. Journal of Telenursing (JOTING), 1(2), 236–245. https://doi.org/10.31539/joting.v1i2.853 Nahar, B. et al. (2020) ‘Early childhood development and stunting: Findings from the MAL-ED birth cohort study in Bangladesh’, Maternal and Child Nutrition, 16(1). Available at: https://doi.org/10.1111/mcn.12864. Nesy, A. M., & Pujaningsih, P. (2023). Deteksi Dini Tumbuh Kembang pada Anak Usia Pra Sekolah. Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini, 7(4), 4682–4689. https://doi.org/10.31004/obsesi.v7i4.4517 Nursalam. (2014). Nursing Care for Infants and Children. Salemba Medika. Pandita, A., Sharma, D., Pandita, D., Pawar, S., Tariq, M., & Kaul, A. (2016). Childhood obesity: prevention is better than cure. Diabetes, metabolic syndrome, and obesity: targets and therapy, 9, 83–89. https://doi.org/10.2147/DMSO.S90783. Patel, A.B. et al. (2019) ‘M-SAKHI—Mobile health solutions to help community providers promote maternal and infant nutrition and health using a community-based cluster randomized controlled trial in rural India: A study protocol’, Maternal and Child Nutrition, 15(4), pp. 1–16. https://doi.org/10.1111/mcn.12850 Rahayu, S. F., Anggeriyane, E., & Mariani, M. (2021). Efforts to Strengthen Stimulation, Detection and Early Development and Development Program (SDIDTK) Through Anthropometric Examination in Preschool Children. Jurnal EMPATI (Edukasi Masyarakat, Pengabdian Dan Bakti), 2(1), 71. https://doi.org/10.26753/empati.v2i1.522 Roba, A.A. et al. (2021) ‘Prevalence and determinants of concurrent wasting and stunting and other indicators of malnutrition among children 6–59 months old in Kersa, Ethiopia’, Maternal and Child Nutrition, 17(3), pp. 1–12. https://doi.org/10.1111/mcn.13172. Sari, K. and Sartika, R.A.D. (2021) ‘The effect of the physical factors of parents and children on stunting at birth among newborns in Indonesia’, Journal of Preventive Medicine and Public Health, 54(5), pp. 309–316. https://doi.org/10.3961/jpmph.21.120. SDIDTK. (2016). Pedoman Pelaksanaan Stimulasi, Deteksi dan lntervensi Dini Tumbuh Kembang Anak. Direktorat Kesehatan Departmen Kesehatan Keluarga, 59. Shofiyati, et al. (2022). The Role of Teachers in Online Learning for Early Childhood Children in the Covid-19 Pandemic Era. Golden Generation: Journal of Ear-Ly Childhood Islamic Education., Vol. 5 No.https://journal.uir.ac.id/index.php/generationemas/article/view/8891 Shrestha, M.L. et al. (2022) ‘Malnutrition matters: Association of stunting and underweight with early childhood development indicators in Nepal’, Maternal and Child Nutrition, 18(2), pp. 1–9. https://doi.org/10.1111/mcn.13321. Soetjiningsih. (2014). Child Development. EGC. Suharsimi Arikunto. (2014). Prosedur Penelitian Suatu Pendekatan Praktik. Rineka Cipta. Suprayitno, E., Yasin, Z., Kurniati, D., & Rasyidah. (2021). Peran Keluarga Berhubungan dengan Tumbuh Kembang Anak Usia Pra Sekolah. Journal of Health Science, VI(II), 63–68. Tanuwijaya, S. (2014). General Concept of Growth and Development. EGC. Vanderloo, L.M. et al. (2021) ‘Selecting and evaluating mobile health apps for the healthy life trajectories initiative: Development of the eHealth resource checklist’, JMIR m Health and uHealth, 9(12), pp. 1–8. https://doi.org/10.2196/27533. Wahyudin, T. E. (2021). Handbook for Stimulation and Detection of Child Growth and Development (0-6 Years). EDU Publisher. Wahyuni, T. (2019). Diagnostic Test of the Mother Cares Application (Moca) for Early Detection of the Risk of Developmental Deviations in Toddlers. Unsika Journal, Vol 4 No 1. Winda Windiyani, Sri Wahyuni, E. N. P. (2020). STIMULASI DETEKSI INTERVENSI DINI TUMBUH KEMBANG ANAK. EDU Publisher. Wulandari, U. R., Budihastuti, U. R., & Poncorini, E. P. (2017). Analysis of Life-Course Factors Influencing Growth and Development in Children under 3 Years Old of Early Marriage Women in Kediri. Journal of Maternal and Child Health, 02(02), 137–149. https://doi.org/10.26911/thejmch.2017.02.02.05

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Kunze, Kyle N., Jeevana J. Pakanati, Amar S. Vadhera, Evan M. Polce, Brady T. Williams, Kevin C. Parvaresh y Jorge Chahla. "The Efficacy of Platelet-Rich Plasma for Ligament Injuries: A Systematic Review of Basic Science Literature With Protocol Quality Assessment". Orthopaedic Journal of Sports Medicine 10, n.º 2 (1 de febrero de 2022): 232596712110665. http://dx.doi.org/10.1177/23259671211066504.

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Background: Despite the existence of many clinical studies on platelet-rich plasma (PRP) interventions for ligamentous pathology, basic science consensus regarding the indications, mechanisms, and optimal composition of PRP for treating ligament injuries is lacking. Purpose: To (1) compare the efficacy of PRP in animal models of ligament injury with placebo and (2) describe the potential variability in PRP preparation using accepted classification systems. Study Design: Systematic review. Methods: The Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, PubMed, Embase, and Ovid MEDLINE were queried in April 2020 for in vivo and in vitro basic science studies regarding PRP use for ligament injury. Study design, results, PRP composition, and analyzed cellular and molecular markers were extracted, and outcomes relative to control models were documented. Bias was assessed using the SYRCLE risk-of-bias tool. Results: Included were 43 articles (31 in vivo and 12 in vitro studies) investigating the anterior cruciate ligament/cranial cruciate ligament (n = 32), medial collateral ligament (n = 6), suspensory ligament (n = 3), patellar ligament (n = 1), and Hock ligament (n = 1). Platelet concentration was reported in 34 studies (77.3%); leukocyte composition, in 12 (27.3%); and red blood cell counts, in 7 (15.9%). With PRP treatment, 5 of 12 in vitro studies demonstrated significant increases in cell viability, 6 of 12 in gene expression, 14 of 32 in vivo studies reported superior ligament repair via histological evaluation, and 13 in vivo studies reported superior mechanical properties. Variability in PRP preparation methods was observed across all articles, and only 1 study reported all necessary information to be classified by the 4 schemes we used to evaluate reporting. Among the in vivo studies, detection and performance bias were consistently high, whereas selection, attrition, reporting, and other biases were consistently low. Conclusion: Conflicting data on the cellular and molecular effects of PRP for ligament injuries were observed secondary to the finding that included studies were heterogeneous, limiting interpretation across studies and the ability to draw meaningful conclusions. Clinical trials and any causal relationship between PRP use in ligament injuries and its potential for regeneration and healing should be pursued with caution if based solely on basic science data.

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Do Carmo de Souza, Danilo, Arianny De Sousa Lira, Francisco Ellivelton Barbosa y Juscileide Braga de Castro. "Prototipação de puzzles geométricos para o Ensino Médio: desafios e contribuições do ensino remoto emergencial (Prototyping geometric puzzles for high school: challenges and contributions of emergency remote education)". Revista Eletrônica de Educação 15 (30 de noviembre de 2021): e5034052. http://dx.doi.org/10.14244/198271995034.

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e5034052The pandemic caused by the new coronavirus affected different sectors of society, among them, the school, with this, the school community had to reevaluate its forms of interaction and one of the strategies implemented was the development of emergency remote education, with the use of Digital Information and Communication Technologies (DICT). That said, this article aims to analyze the challenges and contributions of a training, carried out through emergency remote teaching, on the teaching of Spatial Geometry from the use of different technological tools. The training was carried out with twenty mathematics teachers from different regions of Brazil. The meetings and the execution of the activities were held between the months of May and June 2020, completely at a distance, organized in five synchronous meetings (Google Meet) and asynchronous (Google Classroom and Whatsapp). The research, with a qualitative approach, used as instruments for data collection: video recordings, activities developed with the GeoGebra software, as well as protocols of asynchronous activities. The results obtained through content analysis indicate contributions related to appropriation and technological deepening; professional development and collaborative networking. For future studies, it is intended to expand the workshop to new classes, including teachers from the early years of elementary school or in initial training and with students of different school levels.ResumoA pandemia provocada pelo novo coronavírus afetou diferentes setores da sociedade, dentre eles, a escola, com isso, a comunidade escolar precisou reavaliar suas formas de interação e uma das estratégias implementadas foi o desenvolvimento do ensino remoto emergencial, com a utilização de Tecnologias Digitais de Informação e Comunicação (TDIC). Isso posto, este artigo tem como objetivo analisar os desafios e as contribuições de uma formação, realizada por meio do ensino remoto emergencial, sobre o ensino de Geometria Espacial, a partir da utilização de diferentes ferramentas tecnológicas. A formação foi realizada com vinte professores de Matemática de regiões distintas do Brasil. Os encontros e a execução das atividades foram realizados entre os meses de maio e junho de 2020, completamente a distância, organizados em cinco encontros síncronos (Google Meet) e assíncronos (Google Classroom e Whatsapp). A pesquisa, com abordagem qualitativa, utilizou como instrumentos para a coleta de dados: videogravações, atividades desenvolvidas com o software GeoGebra, além de protocolos de atividades assíncronas. Os resultados, obtidos por meio da análise de conteúdo, indicam contribuições relacionadas com a apropriação e aprofundamento tecnológico, o desenvolvimento profissional e a formação de rede colaborativa. Para estudos futuros, pretende-se expandir a oficina para novas turmas, incluindo professores dos anos iniciais do Ensino Fundamental ou em formação inicial e com estudantes de diferentes níveis escolares.Palavras-chave: Ensino remoto, TDIC, Geometria Espacial, Formação docente.Keywords: Remote teaching, DICT, Spatial Geometry, Teacher Education.ReferencesALVES, Lynn. Educação remota: entre a ilusão e a realidade: Remote education: between illusion and reality / Educación remota: entre ilusión y realidad. Interfaces Científicas, Aracaju, v. 8, n. 3, p. 348-365, 2020.ARRUDA, Eucidio Pimenta. Educação remota emergencial: elementos para políticas públicas na educação brasileira em tempos de Covid-19. EmRede: Revista de Educação a Distância, Porto Alegre, v. 7, n. 1, p. 257-275, 2020.BENK, Polyana; SILVA, Sérgio Marconi da; FIGUEIREDO, Elisandra Bar de; SIPLE, Ivanete Zuchi. O Princípio de Cavalieri: numa abordagem apoiada pelas tecnologias atuais. Colóquio Luso-Brasileiro de Educação – COLBEDUCA. V. 1. 2016BARBOSA, Cirléia Pereira. Desenvolvimento do Pensamento Geométrico nos anos iniciais do Ensino Fundamental: uma proposta de ensino par/a professores e formadores de professores. 2011. 65p. Dissertação (Mestrado Profissionalizante em Educação Matemática da Universidade Federal de Ouro Preto) – Universidade Federal de Ouro Preto, Belo Horizonte, 2011.BARDIN, Laurence. Análise de conteúdo. São Paulo: Edições 70. 2011.BRASIL. Decreto nº 9057, de 25 de maio de 2017. Regulamenta o art. 80 da Lei nº 9.394, de 20 de dezembro de 1996, que estabelece as diretrizes e bases da educação nacional. 2017. Disponível em: http://www.planalto.gov.br/ccivil_03/_Ato2015- 2018/2017/ Decreto/D9057.htm. Acesso em: 19 de agosto de 2020.BRASIL. Ministério da Educação. Base Nacional Comum Curricular - BNCC. Brasília, 2018.CASTRO, Juscileide Braga de. Construção do conceito de covariação por estudantes do ensino fundamental em ambientes de múltiplas representações com suporte das tecnologias digitais. 275f. – Tese (Doutorado) – Universidade Federal do Ceará, Programa de Pós-graduação em Educação Brasileira, Fortaleza (CE), 2016.COSTA, Adriano Ribeiro da. A Educação a Distância no Brasil: Concepções, histórico e bases legais. Rios Eletrônica - Revista Científica da Faculdade Sete de Setembro. Paulo Afonso, BA, a. 11, n. 12, p. 59-74, 2017.GARRIDO, Yolanda Proenza; LEYVA, Luis Manuel Leyva. Pensamiento geométrico en los escolares primarios: un modelo didáctico para estimularlo. In: Congresso Internacional de Matemática e computação, 2005, Holguín. Anais eletrônicos... Holguín., 2005.GOMES, Luiz Fernando. EaD no Brasil: perspectivas e desafios. Avaliação (Campinas), Sorocaba, v. 18, n. 1, pág. 13-22. 2013. Disponível em: https://www.scielo.br/scielo.php?pid=S141440772013000100002script=sci_arttexttlng=pt. Acesso: 19 de agosto de 2020.GUEDES, Fátima de Fátima dos Santos; CARVALHO, Carlos Vitor de Alencar. CONSTRUFIG3D e VISUALFIG3D: softwares potencialmente significativos para o ensino da geometria espacial. Revista de Educação, Ciências e Matemática v.2 n.3 set/dez 2012.HECK, Miriam Ferrazza. Considerações sobre a base nacional comum curricular (BNCC) e as unidades de conhecimento matemático. Revista Eletrônica Científica Ensino Interdisciplinar. Mossoró, v. 5, n. 13, 2019.HODGES, Charles; MOORE, Stephanie; LOCKEE, Barb; TRUST, Torrey; BOND, Aaron. (2020). The difference between emergency remote teaching and online learning. EDUCAUSE Review. 27 março 2020. Disponível em: https://er.educause.edu/articles/2020/3/the-difference-between-emergency-remote-teaching-and-online-learning. Acesso em: 20 agosto 2020.IMBERNÓN, Francisco. Formação docente e profissional: formar-se para a mudança e a incerteza. São Paulo: Cortez, 2004.KALEFF, Ana Maria Martensen Roland. Da Rigidez do Olhar Euclidiano às (Im)Possibilidades de (Trans)Formação dos Conhecimentos Geométricos do Professor de Matemática. 2004. Tese de Doutorado. Faculdade de Educação-UFF. Niterói. 450 p., 2004.KALEFF, Ana Maria Martensen Roland. Vendo e entendendo poliedros: do desenho ao cálculo do volume através de quebra-cabeças e outros materiais concretos. Niterói: EdUFF, 2003.LIRA, Arianny de Sousa; LEITÃO, Darlene Alves; CASTRO, Juscileide Braga de. Como o Processo de Produção de Mídias pode contribuir para a Formação Docente? Renote. Revista Novas Tecnologias na Educação, v. 17, p. 425-434, 2019.LORENZATO, Sergio. Para Aprender Matemática. Campinas: Autores Associados. 2006.NÓVOA, António. Professores: imagens do futuro presente. Campo Grande: OMEP/BR/MS, 2016.PAPERT, Seymour. Logo: Computadores e Educação. 3ª ed. São Paulo: Editora brasiliense s.a. 1985.PAPERT, Seymour. A máquina das crianças: repensando a escola na era da informática. Trad. Sandra Costa. Ed. revisada. Porto Alegre: Artmed, 2008.PALLOFF, Rena M.; PRATT, Keith. O Aluno Virtual: um guia para trabalhar com estudantes on-line. São Paulo: Artmed, 216 p., 2004.PONTE, João Pedro da. O desenvolvimento profissional do professor de Matemática. Educação e Matemática, n.31, p. 9-12 e 20, 1994.PONTE, João Pedro da; OLIVEIRA, Hélia; VARANDAS, José Manuel. O contributo das tecnologias de informação e comunicação para o desenvolvimento do conhecimento e da identidade profissional. In: FIORENTINI, D. (org.). Formação de Professores de Matemática: explorando novos caminhos com outros olhares. Campinas: Mercado de Letras, 2003. p. 159-192.PRIMO, Márcio Eduardo. O princípio de Cavalieri para o cálculo de volumes no ensino médio: algumas possibilidades. 2013. Dissertação (Mestrado Profissional em Matemática em Rede Nacional) Universidade Federal de Juiz de Fora, Juiz de Fora, 2013.RODRIGUES, Danielle dos Santos; KAIBER, Carmen Teresa. A Geometria Espacial no Ensino Médio: contribuições da utilização de uma Unidade de Ensino e Aprendizagem (UEA). Perspectivas da Educação Matemática, v. 12, n. 28, p. 149-167, dez. 2019.SOUZA, Danilo do Carmo de; LIRA, Arianny de Sousa; BARBOSA, Francisco Ellivelton; CASTRO, Juscileide Braga de. Tecnologias Digitais e Geometria Espacial: contribuições de uma formação de professores na perspectiva do ensino remoto. In: SIMPÓSIO BRASILEIRO DE INFORMÁTICA NA EDUCAÇÃO, 31., 2020, Online. Anais [...]. Porto Alegre: Sociedade Brasileira de Computação, 2020. p. 272-281. DOI: https://doi.org/10.5753/cbie.sbie.2020.272.SOUZA JÚNIOR, José Carlos de; CARDOSO, Andrea; CALIXTO, Rejiane Aparecida. GeoGebra 3D uma ferramenta para estudo de volumes no ensino médio. Revista da Universidade Vale do Rio Verde, ISSN-e 2236-5362, ISSN 1517-0276, Vol. 12, Nº. 1, 2014, págs. 755-764. 2014.

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Alhammad, Nasser, Mohannad Alajlani, Alaa Abd-alrazaq, Theodoros Arvanitis y Gregory Epiphaniou. "Patients and Stakeholders’ Perspectives Regarding the Privacy, Security, and Confidentiality of Data Collected via Mobile Health Apps in Saudi Arabia: Protocol for a Mixed Method Study". JMIR Research Protocols 13 (22 de mayo de 2024): e54933. http://dx.doi.org/10.2196/54933.

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Background There is data paucity regarding users’ awareness of privacy concerns and the resulting impact on the acceptance of mobile health (mHealth) apps, especially in the Saudi context. Such information is pertinent in addressing users’ needs in the Kingdom of Saudi Arabia (KSA). Objective This article presents a study protocol for a mixed method study to assess the perspectives of patients and stakeholders regarding the privacy, security, and confidentiality of data collected via mHealth apps in the KSA and the factors affecting the adoption of mHealth apps. Methods A mixed method study design will be used. In the quantitative phase, patients and end users of mHealth apps will be randomly recruited from various provinces in Saudi Arabia with a high population of mHealth users. The research instrument will be developed based on the emerging themes and findings from the interview conducted among stakeholders, app developers, health care professionals, and users of mHealth apps (n=25). The survey will focus on (1) how to improve patients’ awareness of data security, privacy, and confidentiality; (2) feedback on the current mHealth apps in terms of data security, privacy, and confidentiality; and (3) the features that might improve data security, privacy, and confidentiality of mHealth apps. Meanwhile, specific sections of the questionnaire will focus on patients’ awareness, privacy concerns, confidentiality concerns, security concerns, perceived usefulness, perceived ease of use, and behavioral intention. Qualitative data will be analyzed thematically using NVivo version 12. Descriptive statistics, regression analysis, and structural equation modeling will be performed using SPSS and partial least squares structural equation modeling. Results The ethical approval for this research has been obtained from the Biomedical and Scientific Research Ethics Committee, University of Warwick, and the Medical Research and Ethics Committee Ministry of Health in the KSA. The qualitative phase is ongoing and 15 participants have been interviewed. The interviews for the remaining 10 participants will be completed by November 25, 2023. Preliminary thematic analysis is still ongoing. Meanwhile, the quantitative phase will commence by December 10, 2023, with 150 participants providing signed and informed consent to participate in the study. Conclusions The mixed methods study will elucidate the antecedents of patients’ awareness and concerns regarding the privacy, security, and confidentiality of data collected via mHealth apps in the KSA. Furthermore, pertinent findings on the perspectives of stakeholders and health care professionals toward the aforementioned issues will be gleaned. The results will assist policy makers in developing strategies to improve Saudi users’/patients’ adoption of mHealth apps and addressing the concerns raised to benefit significantly from these advanced health care modalities. International Registered Report Identifier (IRRID) DERR1-10.2196/54933

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Andriamasinavalona, Rajaonarison Lala, Rasaholiarison Nomena Finiavana, Razafindrasata Ratsitohara Santatra, Razafimahefa Julien, Zodaly Noël y Tehindrazanarivelo Alain Djacoba. "Mortalite A La Phase Aiguë De L’avc Hemorragique Sous Notre Protocole De Baisse De La Tension Arterielle A l’Hopital Universitaire (HU) Befelatanana Antananarivo". European Scientific Journal, ESJ 14, n.º 18 (30 de junio de 2018): 325. http://dx.doi.org/10.19044/esj.2018.v14n18p325.

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Introduction: Hemorrhagic stroke can be seen in 90% of cases with high blood pressure. It is a predictor of intra-hospital mortality. Our goal is to compare the mortality rate based on admission under our therapeutic strategy for HTA in the acute phase of stroke. Method: A retrospective descriptive, cross-sectional study of consecutive patients was conducted over a 12-month period during the year 2017. Results: We had 20% (3/15) mortality rate in acute phase in those with systolic blood pressure (SBP) in admission at ≥ 180 mmHg (group II) and no death (0/17) was recorded in the those with SBP in admission at 140-179mmHg (group I). A SBP at the 7th day (D7) less than 140 mmHg was not rich in those two groups: 35.29 % in group I (n=6) and 46.66 % in group II (n=7) respectively. The sex ratio was 1. High blood pressure remains the main cardio-vascular risk factor reported in our study (81.21%). All our patients had Glasgow scale value between 13-15 and only the NIHSS value > 10 was associated with high blood pressure in acute phase (p=0.0131). Brain CT Scan was realised in majority of cases at the second day (D2) of stroke (n=16). This, however, is with localisation preference in the basal ganglia, with intra-cerebral hemmorhage (ICH) scale at 1 in 65.62% (n=21) of cases. Conclusion: Intra-hospital mortality in acute phase of hemorrhagic stroke remains high. Instauration of stroke field in Madagascar is necessary and this gives the Befelatanana University Hospital a Neuro- Vascular Intensive Care Unit too.

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Priyanti, Nita y Jhoni Warmansyah. "The Effect of Loose Parts Media on Early Childhood Naturalist Intelligence". JPUD - Jurnal Pendidikan Usia Dini 15, n.º 2 (30 de noviembre de 2021): 239–57. http://dx.doi.org/10.21009/jpud.152.03.

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Naturalist intelligence of early childhood has a very big role in today's modern age as the basis for children to have environmental-loving behaviour. The purpose of this study was to determine the effect of Loose Parts learning media on the naturalist intelligence. This study uses a quasi-experimental method with data collection techniques through multiple intelligence tests of children's intelligence instruments. The subjects of this study were 17 children aged 5-6 years. The results showed that there was a significant effect of giving Loose Parts media to the naturalist intelligence of early childhood after seeing a difference between pre-test and post-test. The use of natural-based Loose Parts media can be a means for teachers to increase children's naturalist intelligence in kindergarten and be a development of conventional media made from manufacturers in the learning cycle so far. For further research, it is recommended to look at the influence of other factors on naturalist intelligence in early childhood. Keywords: Early Childhood, Loose Parts, Naturalist Intelligence References: Aljabreen, H. (2020). Montessori, Waldorf, and Reggio Emilia: A Comparative Analysis of Alternative Models of Early Childhood Education. International Journal of Early Childhood, 52(3), 337–353. https://doi.org/10.1007/s13158-020-00277-1 Anjari, T. Y., & Purwanta, E. (2019). Effectiveness of the Application of Discovery Learning to the Naturalist Intelligence of Children About the Natural Environment in Children Aged 5-6 Years. International Conference on Special and Inclusive Education (ICSIE 2018), 296, 356–359. https://doi.org/10.2991/icsie-18.2019.65 Armstrong, T. (2002). You’re Smarter Than You Think: A Kid’s Guide to Multiple Intelligences. Free Spirit Publishing Inc., 217 Fifth Ave., North, Suite 200, Minneapolis, MN 55401-1299. Asih, S., & Susanto, A. (2017). Peningkatan Kecerdasan Naturalis Pada Anak Usia 5-6 Tahun Melalui Model Pembelajaran Di Sentra Bahan Alam. Yaa Bunayya: Jurnal Pendidikan Anak Usia Dini, 1(1). https://doi.org/10.24853/yby.1.1.33-38 Ata-Akturk, A., & Sevimli-Celik, S. (2020). Creativity in early childhood teacher education: Beliefs and practices. International Journal of Early Years Education, 1–20. https://doi.org/10.1080/09669760.2020.1754174 Azizah, E. N. (2021). Peningkatan Kecerdasan Naturalis Melalui Kolase Bahan Alam Pada Anak Kelompok A TK Kemala Bhayangkari 54 Ngawi. Journal of Childhood Education, 5(1). https://doi.org/10.30736/jce.v5i1.491 Damayanti, A., Akbar, M., & Yufiarti, Y. (2019). The Interaction Effect of Learning Methods and Naturalist Intelligence Toward Children’s Art Creativity. Proceedings of the First International Conference on Technology and Educational Science. https://doi.org/10.4108/eai.21-11-2018.2282278 Diana, H., Diana, S., & Wulan, A. R. (2019). Hubungan antara kecerdasan naturalis dengan sikap lingkungan. Konferensi Internasional Tentang Biologi Dan Sains Terapan (ICOBAS). Ebrahimi, T. (2017). Effect of Technology on Education in Middle East: Traditional Education Versus Digital Education. In Digital Transformation in Journalism and News Media (pp. 519–531). Springer International Publishing. https://doi.org/10.1007/978-3-319-27786-8_38 Faridy, F., & Rohendi, A. (2021). The Role of Parents in Engaging Early Childhood to Implement 3R (Reduce, Reuse, Recycle). Proceedings of the International Conference on Engineering, Technology and Social Science (ICONETOS 2020), 529(Iconetos 2020), 483–486. https://doi.org/10.2991/assehr.k.210421.070 Fatonah, S., & Prasetyo, Z. K. (2018). Science Learning Model To Improve Naturalist Intelligence For Early Childhood. Sunan Kalijaga International Journal on Islamic Educational Research, 1(1), 34–50. https://doi.org/10.14421/skijier.2017.2017.11-03 Flannigan, C., & Dietze, B. (2018). Children, Outdoor Play, and Loose Parts. Journal of Childhood Studies, 53–60. https://doi.org/10.18357/jcs.v42i4.18103 Furi, A. Z., Harmawati, Denok, M., & B.A. (2019). Meningkatkan Kemampuan Kognitif melalui Penerapan Metode Eksperimen Menggunakan Media Loose Parts pada Anak Kelompok B. Emphaty Cons: Journal of Guidance and Counseling, 1(2), 7–19. Gardner, H. (1994). Frames Of Mind. New York, NY, Basic Books. Gibson, J. L., Cornell, M., & Gill, T. (2017). A Systematic Review of Research into the Impact of Loose Parts Play on Children’s Cognitive, Social and Emotional Development. School Mental Health, 9(4), 295–309. https://doi.org/10.1007/s12310-017-9220-9 Gold, Z. S., & Elicker, J. (2020). Engineering Peer Play: A New Perspective on Science, Technology, Engineering, and Mathematics (STEM) Early Childhood Education (pp. 61–75). https://doi.org/10.1007/978-3-030-42331-5_5 Gull, C., Bogunovich, J., Goldstein, S. L., & Rosengarten, T. (2019). Definitions of Loose Parts in Early Childhood Outdoor Classrooms: A Scoping Review Carla Gull Jessica Bogunovich Suzanne Levenson Goldstein Tricia Rosengarten. International Journal of Early Childhood Environmental Education Copyright, 6(3), 37–52. Hafizotun, L. (2017). Pemberdayaan Sentra Bahan Alam Untuk Mengembangkan Kecerdasan Naturalis Anak Usia Dini Di Taman Kanak-Kanak Islam Terpadu Nurul Ilmi Kota Jambi. Jurnal Al-Ashlah, 1(Vol 1, No 2 (2017)). Hapidin, Gunarti, W., Pujianti, Y., & Siti Syarah, E. (2020). STEAM to R-SLAMET Modification: An Integrative Thematic Play Based Learning with R-SLAMETS Content in Early Child-hood Education. JPUD - Jurnal Pendidikan Usia Dini, 14(2), 262–274. https://doi.org/10.21009/JPUD.142.05 Hartika, D., Diana, S., & Wulan, A. R. (2019). Relationship between naturalist intelligence with environmental attitude. 060017. https://doi.org/10.1063/1.5115717 Herwati, Y. (2019). Pengaruh Permainan Ludo Bergambar Terhadap Kecerdasan Naturalis Anak di Taman Kanak-kanak Tunas Bangsa Bukittinggi. Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini, 4(1), 428. https://doi.org/10.31004/obsesi.v4i1.358 Houser, N. E., Cawley, J., Kolen, A., Rainham, D., Rehman, L., Turner, J., Kirk, S., & Stone, M. (2019). A Loose Parts Randomized Controlled Trial to Promote Active Outdoor Play in Preschool-aged Children: Physical Literacy in the Early Years (PLEY) Project. Methods and Protocols, 2(2), 27. https://doi.org/10.3390/mps2020027 Houser, N. E., Roach, L., Stone, M. R., Turner, J., & Kirk, S. F. L. (2016). Let the Children Play: Scoping Review on the Implementation and Use of Loose Parts for Promoting Physical Activity Participation. AIMS Public Health, 3(4), 781–799. https://doi.org/10.3934/publichealth.2016.4.781 Imamah, Z., & Muqowim, M. (2020). Pengembangan kreativitas dan berpikir kritis pada anak usia dini melalui motode pembelajaran berbasis STEAM and loose part. 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Levay, Paul y Jenny Craven. "Systematic Searching in a Post-Pandemic World: New Directions for Methods, Technology, and People". Evidence Based Library and Information Practice 18, n.º 4 (15 de diciembre de 2023): 93–104. http://dx.doi.org/10.18438/eblip30415.

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Manser, Patrick y Eling D. De Bruin. "Brain-IT: Targeting the brain using information technology for secondary prevention of mild neurocognitive disorder". Current Issues in Sport Science (CISS) 9, n.º 2 (6 de febrero de 2024): 021. http://dx.doi.org/10.36950/2024.2ciss021.

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Introduction A collaborative international guideline recommends physical exercise (PE) for the secondary prevention of mild neurocognitive disorder (mNCD; Veronese et al., 2023). PE is proposed to promote brain plasticity, maintain or increase cognitive reserve, and alleviate the pathological state in individuals with mNCD, which is characterized by an abnormal accumulation of proteins, excessive oxidative stress, metabolic disorder, and neuroinflammation within the brain (Lu et al., 2023). Individuals with mNCD often also have disrupted self-regulatory capacity to flexibly adapt to daily life challenges. This capacity is supported by the central autonomic network (CAN), which can be viewed as an integrated component of an internal regulatory system in which the brain controls visceromotor, neuroendocrine, and behavioral responses that are critical for goal-directed behavior, adaptability, and health (Thayer, 2009). To maximize the effectiveness of secondary prevention of mNCD, interventions should be designed to also target this network specifically. This could be achieved by combining motor-cognitive training with resonance breathing guided by heart rate variability biofeedback (HRV-BF). HRV-BF training aims to increase cardiac autonomic control, enhance homeostatic regulation, and regulate emotional state. It is effective in improving cardiac autonomic control, cognitive functioning (in particular executive functions), and emotional regulation (i.e., by decreasing symptoms of depression, anxiety, and stress) across different age groups and clinical populations (Laborde et al., 2022; Lehrer et al., 2020). Evidence also supports a causal role of cardiac autonomic control in modulating plasma Alzheimer’s disease-related biomarkers (Min et al., 2023). Although HRV-BF has been suggested as a complementary treatment (Lehrer et al., 2020), its combination with motor-cognitive training remains to be investigated. Methods We systematically designed, developed, and evaluated a novel training concept (called ‘Brain-IT’) specifically for older adults with mNCD. It addresses the mechanism of action described above. The projects’ methodology (Manser & de Bruin, 2021) followed the guidelines of the Medical Research Council for the development and evaluation of complex interventions as well as the Multidisciplinary Iterative Design of Exergames (MIDE) - Framework. The Brain-IT project was structured in three phases. In phase 1, we systematically combined a comprehensive literature synthesis (Manser & de Bruin, 2021) with qualitative research including primary end users (older adults with mNCD), secondary end users (physiotherapists, occupational therapists, healthcare professionals), exergaming researchers, as well as experts from the exergaming industry (Manser et al., 2023) to specify a set of design requirements for the Brain-IT training concept. In phase 2, possible concepts were co-designed and elaborated based on the set of design requirements defined in phase 1. The first prototype of the resulting Brain-IT training concept (Manser & de Bruin, 2021) then entered the iterative cycle of feasibility, usability, safety, and acceptance testing and integrating study results for further development based on co-design until an "acceptable" solution was achieved. In this regard, we conducted a pilot randomized controlled study (RCT) including 18 individuals with mNCD. (Manser et al., 2023) Finally, in phase 3, the effectiveness of the addition of the Brain-IT training to usual care to improve global cognitive functioning is investigated in a RCT including 41 individuals with mNCD (study protocol: Manser et al., 2023). As secondary objectives, the effects of the Brain-IT training on: (1) domain-specific cognitive functioning, (2) spatiotemporal parameters of gait, (3) instrumental activities of daily living and (4) psychosocial factors (i.e. quality of life, and levels of depression, anxiety, and stress), and (5) cardiac vagal modulation are explored. Additionally, brain structure and function is evaluated by magnetic resonance imaging to explore underlying neural changes of the training in relation to adaptations in cognitive performance. Results Ten secondary end users, exergaming researchers, and experts from the exergaming industry (80% females) and eight older adults with mNCD (38% females) contributed to the qualitative research (Manser et al., 2023) which allowed us to successfully integrate all the acquired knowledge of phase 1 to determine a set of design requirements (Manser & de Bruin, 2021). This set of design requirements built the basis for phase 2, where we developed a first prototype of the Brain-IT training concept. Our reflections on the design considerations and our proposed solutions are summarized in (Manser & de Bruin, 2021; Manser et al., 2023). The Brain-IT training concept represents a guideline for applying a combination of exergame-based motor-cognitive training and HRV-BF training by standardizing the training characteristics as well as the structure and content of training and can be implemented with different hardware and software solutions. For an overview, the Brain-IT training consists of a personalized and individually adapted multi-domain exergame-based simultaneous motor–cognitive training with incorporated cognitive tasks combined with HRV-BF training. It is adopted with a deficit-oriented focus on the neurocognitive domains of (1) learning and memory, (2) executive function, (3) complex attention, and (4) visuospatial skills. Each participant is instructed to train ≥ 5x/week for ≥ 24 min per session resulting in a weekly training volume of ≥120 min. All training sessions are planned to take place at participants’ homes. In this project, we used technology of Dividat AG, Polar, and Kubios Oy to implement our training concept. In the pilot RCT we showed that Brain-IT training is feasible (mean adherence and compliance rates of 85.0 and 84.1%, respectively) and usable (mean system usability scale = 71.7 ± 15.4). In addition, high levels of exergame enjoyment, an increase in exergame enjoyment, and internalization of training motivation with large effect sizes (p = 0.03, r = 0.75 and p = 0.03, r = 0.74, respectively), as well as acceptable perceived usefulness were observed. Phase 3 is ongoing. To date, 41 participants were included into the study, of which two withdrew consent before pre-measurements, two dropped-out during intervention (one in each group), and 29 (72.6 ± 9.3 years; 24.1% females) successfully completed the study. Preliminary data suggest significant effects with large effects sizes in favor of the intervention group for global cognitive functioning (F(1, 29) = 4.692, p = 0.039, partial η2 = 0.153) as well as immediate (F(1, 29) = 6.501, p = 0.018, partial η2 = 0.213) and delayed (F(1, 29) = 5.227, p = 0.031, partial η2 = 0.179) verbal recall. The remaining (underpowered) statistical analyses revealed no significant effects, but favorable changes in descriptive statistics with small to moderate effects in favor of the intervention group, especially with regards to quality of life. Discussion/Conclusion The development of novel (exergame-based) training concepts is greatly facilitated when it is based on a theoretical framework. Applying the MIDE-framework resulted in a structured, iterative, and evidence-based approach that led to the identification of multiple key requirements for the exergame design as well as the training components that otherwise may have been overlooked or neglected. This resulted in a user-centered, personalized, and highly innovative training concept that is feasible, usable, and highly accepted by individuals with mNCD. Preliminary data regarding the effectiveness of the intervention is promising, suggesting that the training significantly improved global cognitive functioning, verbal immediate, and delayed recall with large effect sizes, and tends to be beneficial in improving quality of life. To be able to conclude about the effectiveness of the Brain-IT training concept, a full-scale confirmatory randomized controlled superiority trial is warranted. References Laborde, S., Aelle, M. S., Borges, U., Dosseville, F., Hosang, T. J., Iskra, M., Mosley, E., Salvotti, C., Spolverator, L., Zammit, N., & Javelle, F. (2022). Effects of voluntary slow breathing on heart rate and heart rate variability: A systematic review and a meta-analysis. Neuroscience & Biobehavioral Reviews, 138, Article 104711. https://doi.org/10.1016/j.neubiorev.2022.104711 Lehrer, P., Kaur, K., Sharma, A., Shah, K., Huseby, R., Bhavsar, J., Sgobba, P., & Zhang, Y. (2020). Heart rate variability biofeedback improves emotional and physical health and performance: A systematic review and meta analysis. Applied psychophysiology and biofeedback, 45(3), 109-129. https://doi.org/10.1007/s10484-020-09466-z Lu, Y., Bu, F.-Q., Wang, F., Liu, L., Zhang, S., Wang, G., & Hu, X.-Y. (2023). Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction. Translational Neurodegeneration, 12(1), 9. https://doi.org/10.1186/s40035-023-00341-5 Manser, P., Adcock-Omlin, M., & de Bruin, E. D. (2023). Design considerations for an exergame-based training intervention for older adults with mild neurocognitive disorder: Qualitative study including focus groups with experts and health care professionals and individual semistructured in-depth patient interviews. JMIR Serious Games, 11, Article e37616. https://doi.org/10.2196/37616 Manser, P., & de Bruin, E. D. (2021). Making the best out of it: Design and development of exergames for older adults with mild neurocognitive disorder - A methodological paper . Front in Aging Neuroscience, 13, Article 734012. https://doi.org/10.3389/fnagi.2021.734012 Manser, P., Michels, L., Schmidt, A., Barinka, F., & de Bruin, E. D. (2023). Effectiveness of an individualized exergame-based motor-cognitive Training concept targeted to improve cognitive functioning in older adults with mild neurocognitive disorder: Study protocol for a randomized controlled trial. JMIR Resarch Protocols, 12, Article e41173. https://doi.org/10.2196/41173 Manser, P., Poikonen, A., & de Bruin, E. D. (2023). Feasibility, usability, and acceptance of “Brain-IT”—A newly developed exergame-based training concept for the secondary prevention of mild neurocognitive disorder: A pilot randomized controlled trial [Original Research]. Frontiers in Aging Neuroscience, 15, Article 1163388. https://doi.org/10.3389/fnagi.2023.1163388 Min, J., Rouanet, J., Martini, A. C., Nashiro, K., Yoo, H. J., Porat, S., Cho, C., Wan, J., Cole, S. W., Head, E., Nation, D. A., Thayer, J. F. & Mather, M. (2023). Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults. Scientific Reports, 13(1), Article 3967. https://doi.org/10.1038/s41598-023-30167-0 Thayer, J. F. (2009). Heart rate variability: A neurovisceral integration model. In L. R. Squire (Ed.), Encyclopedia of Neuroscience (pp. 1041-1047). https://doi.org/10.1016/B978-008045046-9.01991-4 Veronese, N., Soysal, P., Demurtas, J., Solmi, M., Bruyère, O., Christodoulou, N., Ramalho, R., Fusar-Poli, P., Lappas, A. S., Pinto, D., Steen Frederiksen, K., Corbi, G. M., Karpenko, O., Georges, J., Durães, J., Schlögl, M., Yilmaz, O., Sieber, C., Shenkin, S. D., Smith, L., Reginster, J.-Y., … & World Psychiatry Association-Preventive Psychiatry Section. (2023). Physical activity and exercise for the prevention and management of mild cognitive impairment and dementia: a collaborative international guideline. European Geriatric Medicine, 14(5), 925-952. https://doi.org/10.1007/s41999-023-00858-y

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Periódicos, EDIPUCRS. "Erratum - Journal Scientia Medica v.31 n.1 (2021) - ID 40589". Scientia Medica 32, n.º 1 (26 de abril de 2022): e43137. http://dx.doi.org/10.15448/1980-6108.2022.1.43137.

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The Editorial Team of Journal SCIENTIA MEDICA publishes the following changes and replacements, in the edition 31, n. 1 (2021), DOI: https://doi.org/10.15448/1980-6108.2021.1.40589, ID 40589, article, The 12 women who won the Nobel Prize in Medicine or Physiology

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Periódicos, EDIPUCRS. "Erratum - Journal Scientia Medica v.31 n.1 (2021) - ID 40589". Scientia Medica 32, n.º 1 (26 de abril de 2022): e43137. http://dx.doi.org/10.15448/1980-6108.2022.1.43137.

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The Editorial Team of Journal SCIENTIA MEDICA publishes the following changes and replacements, in the edition 31, n. 1 (2021), DOI: https://doi.org/10.15448/1980-6108.2021.1.40589, ID 40589, article, The 12 women who won the Nobel Prize in Medicine or Physiology

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Anemaat, Lisa, Victoria J. Palmer, David A. Copland, Kathryn Mainstone, Kent Druery, Julia Druery, Bruce Aisthorpe, Geoffrey Binge, Penelope Mainstone y Sarah J. Wallace. "Using experience-based codesign to coproduce aphasia rehabilitation services: study protocol". BMJ Open 11, n.º 11 (noviembre de 2021): e047398. http://dx.doi.org/10.1136/bmjopen-2020-047398.

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IntroductionAphasia is an impairment of language that occurs in 30%–40% of stroke survivors. This often chronic condition results in poor outcomes for the individual with aphasia and their family. Long-term aphasia management is limited, with few people receiving sufficient services by 6–12 months postonset. We present a protocol for the development of coproduced aphasia service elements. We will use experience-based codesign (EBCD), an approach that enables service users and providers to collaboratively develop services and care pathways. Drawing on the experiences of people with aphasia, their families and clinicians we will establish priorities for the development of new services and later work together to codesign them.Methods and analysisThis research will be coproduced with people with aphasia (n=30–60), their families (n=30–60) and speech pathologists (n=30–60) in Queensland, Australia, using EBCD. A consumer advisory committee will provide oversight and advice throughout the research. In phase 1, we will use semistructured interviews and the nominal group technique to explore experiences and unmet needs in aphasia rehabilitation. Data will be analysed using thematic analysis and the resulting themes will be prioritised in multistakeholder focus groups. Outcomes of phase 1 will inform future research (phase 2) to codesign services. Financial costs and participant experiences of EBCD will be measured.Ethics and disseminationHuman Research Ethics Committee approval for phase 1 has been obtained (HREC/2020/QRBW/61368). Results will be reported in peer-reviewed journal articles, presented at relevant conferences and, following EBCD suggested best practice, fed back to participants and community members at a celebratory event at completion of the project. The inclusion of service users in all stages of research will facilitate an integrated approach to knowledge translation. A summary of research findings will be made available to participating sites.

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Suresh, Indrani, Chitra Andrew y Suresh Seshadri. "Relationship of Fetal Complications in Monochorionic Diamniotic Twin Pregnancy with Placental Site Cord Insertion: A Retrospective Analysis of 30 Months Data in a Referral Fetal Medicine Center". Journal of South Asian Federation of Obstetrics and Gynaecology 8, n.º 4 (2016): 304–8. http://dx.doi.org/10.5005/jp-journals-10006-1439.

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ABSTRACT Aims Among the increasing twin gestations, monochorionic twins occur in about 12 to 15% of all twin gestations and the occurrence is about 1 in 20 in assistive reproductive technology pregnancies. Early detection of twin to twin transfusion syndrome (TTTS) or selective intrauterine growth restriction (sIUGR) aids the obstetrician in counseling and therapy as required. Materials and methods This is a retrospective cohort study of monochorionic diamniotic (MCDA) pregnancies referred from January 2011 to June 2013. Those cases that had crown rump length and nuchal translucency measurements done in the first trimester and then at least one subsequent scan at > 16 weeks, at the institution were chosen. The objective was to assess the utility of placental site of cord insertion in early second trimester scan to predict fetal outcome in monochorionic twin pregnancy. The patient characteristics, placental cord insertion site, and neonatal outcomes were compared among TTTS, sIUGR, and normal groups. Discussion Of 89 MCDA pregnancies, only 60 had been referred for second trimester scan. Among these, in 48 (80%) of pregnancies, both babies were delivered and discharged alive and well. Cord insertions that were eccentric or central were classified as “type A”. Marginal and velamentous cord insertions were classified as “type B”. Pregnancies with both types A and B insertions were called “concordant cord insertions group” and the others were classified as “discordant cord insertions” group. The two groups were compared to look for the pregnancy complications — TTTS or sIUGR. Results The concordant cord insertions (n = 33) had 84.8% of pregnancies having a normal pregnancy and 12.1 and 3.1% developing sIUGR and TTTS respectively. The discordant cord insertion group (n = 27) had 59.2% with normal findings at the second scan and 14.8 and 26% developing sIUGR and TTTS respectively. The incidence of TTTS was 30% in twin pairs with discordant cord insertions and 3% in twin pairs with concordant cord insertions (p = 0.0158). Cord insertions did not influence the occurrence of sIUGR in our study. (p = 0.69). Significantly more pregnancies with concordant cord insertions had normal outcomes (p = 0.02). Conclusion Determination of placental site of cord insertion should be incorporated into protocols of twin pregnancy care. This is a window of opportunity to gain valuable information regarding the pregnancy. Further large studies incorporating fetal biometric and Doppler parameters could show the relative utility of each parameter in the detection of MCDA vascular complications. If the MCDA pregnancy can be classified as “low risk” then reassessment intervals can be extended. This would help to reduce patient stress and costs involved in repeated scans. How to cite this article Andrew C, Suresh I, Seshadri S. Relationship of Fetal Complications in Monochorionic Diamniotic Twin Pregnancy with Placental Site Cord Insertion: A Retrospective Analysis of 30 Months Data in a Referral Fetal Medicine Center. J South Asian Feder Obst Gynae 2016;8(4):304-308.

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Grosse, Regine, Gisela Janssen, Rainer Engelhardt, Marketa Groeger, Oliver Leismann, Peter Nielsen, Roland Fischer y Gritta Janka. "Chelator Efficacy of Deferasirox and Deferoxamine Determined by SQUID Biosusceptometry." Blood 108, n.º 11 (16 de noviembre de 2006): 1779. http://dx.doi.org/10.1182/blood.v108.11.1779.1779.

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Abstract Chelation treatment of patients with iron overload from chronic blood (RBC) transfusion needs continuous monitoring of iron stores, iron influx rates from RBC, chelation dose rates, and compliance. Molar chelator efficacy depicts the combined effect from these variables. Treatment should always aim to maximize the efficacy of a certain chelator in an individual patient in order to reduce organ damage from iron toxicity. In a prospective trial on the oral chelator deferasirox, a total of 12 patients with b-thalassemia major have been followed by SQUID biomagnetic liver susceptometry in intervals of 6 to 12 months over a time period of up to 38 months under deferasirox. Patients were initially on deferoxamine (DFO, Desferal®) and then participated in an international multi-center trial randomized for s.c. DFO and the oral chelator deferasirox (DSX, Exjade®). Liver iron concentration LIC (μg/g-liver wet weight), liver volumes, RBC transfusion rates, chelation dose rates, and compliance from tablet counts were assessed. Total body iron stores were calculated from total liver iron taking into account that 70 – 90 % of the total body storage iron is accumulated in the liver. For each chelation interval, molar efficacies were calculated from the daily iron input rate due to RBC plus the change in total body iron per interval time (= mobilized iron rate), and the molar dose rate of DFO or DSX (Fischer et al: Ann N Y Acad Sci2005; 1054: 350–7), equation 1. \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \[Molar\ efficacy\ [\%]\ =\ mobilized\ iron\ rate/molar\ chelator\ dose\ rate\] \end{document} LIC values were in the range of 836 to 8404 with a median value of 2424 μg/g-liver, while ferritin levels were between 911 and 13609 μg/l with a median ratio of ferritin-to-LIC of 1.0 ((μg/l)/(μg/g)) (range: 0.4 to 3.2). The median molar dose rates for DFO and DSX were 3.2 and 1.6 mmol/d, respectively. For each patient, the molar efficacies for DFO and DSX were averaged. From these averaged values, a mean molar efficacy ± SD of 13.2 ± 3.4 % and 23.6 ± 10.3 % was found for DFO and DSX, respectively. Relative to DFO, in each patient an increase between 5.5 and 27.1 % was found for DSX (mean: 11.7 ± 7.3 %). Patients with a low efficacy on DFO also had a low molar efficacy on DSX and vice versa (e.g., 8.0 and 13.5 % versus 16.0 and 31.9 %). Compliance assessed from tablet count protocols was larger than 90% and did not change these data significantly. On a larger scale in highly compliant thalassemia patients, a molar efficacy of 17.6 ± 4.8 % was observed (Fischer et al: Brit J Haematol2003; 121: 938–48). In comparison to that reference value, the molar efficacy of DFO for this patient group was decreased. The reported molar efficacy of 27.9 ± 13.8 % for DSX obtained from biopsy results (Porter et al: Blood2005; 106(11): 755a) is only insignificantly higher than our value. In summary, we found deferasirox to be two times more efficient than deferoxamine on the same molar dose level, even for patients with a relatively low efficacy under both chelator treatment regimens.

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Sena, Marina Fernandes de, Késsia Suênia F. de Mesquita, Fernanda Regina R. Santos, Francisco Wanderley G. P. Silva y Kranya Victoria D. Serrano. "Prevalence of temporomandibular dysfunction in children and adolescents". Revista Paulista de Pediatria 31, n.º 4 (diciembre de 2013): 538–45. http://dx.doi.org/10.1590/s0103-05822013000400018.

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OBJECTIVE: To review the prevalence of temporomandibular disorders (TMD) in children and adolescents, verifying the methodological variations. DATA SOURCES: Research conducted in Medline, PubMed, Lilacs and BBO databases, including manuscripts (except reviews and case reports) published from 1990 to 2012. The descriptors were "temporomandibular joint syndrome", "temporomandibular joint dysfunction syndrome", "temporomandibular joint disorders", "prevalence studies", and "cross-sectional studies"; the words "dysfunction", "disorder", "temporomandibular", "children", "adolescents", "prevalence", "frequency", and "transversal" were used. DATA SYNTHESIS: Seventeen articles were selected, and the TMD frequency varied from 16 to 68%. Regarding the methodological criteria, only three articles (18%) reported sample size determination, three (18%) clearly described the sample selection process by stratified selection technique, and nine studies (53%) carried out the calibration of the examiners. The diagnostic criteria used in the studies were: Helkimo index (n=2; 12%), Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) (n=4; 24%), the jaw index (n=1; 6%), clinical protocols (n=10; 59%), and anamnestic questionnaires (n=6; 35%). CONCLUSIONS: The TMD prevalence in children and adolescents varies in the literature. Appropriate and standardized methods are needed to identify, with greater validity, the presence of TMD in this population, allowing a better understanding of the pathological aspects in order to address more effective preventive and therapeutic procedures.

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Dziurzyński, Wacław y Eugeniusz Krause. "Influence of the Field of Aerodynamic Potentials and Surroundings of Goaf on Methane Hazard in Longwall N-12 In Seam 329/1, 329/1-2 in “Krupiński” Coal Mine / Wpływ Pola Potencjałów Aerodynamicznych Oraz Otoczenia Zrobów Na Zagrożenie Metanowe W Ścianie N-12 W Pokładzie 329/1, 329/1-2 W Kwk „Krupiński”". Archives of Mining Sciences 57, n.º 4 (1 de diciembre de 2012): 819–920. http://dx.doi.org/10.2478/v10267-012-0053-y.

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Abstract Designing exploitation in seams in surroundings of strongly methane bearing seam assumes particular importance in conditions of the growing concentration of output. While planning exploitation, calculations results of predictions of methane emission to longwalls form a basis for selection of a mode of ventilation scope of utilized prevention, including methane drainage, as well as planned volume of coal output. Performed in the article, systematic analysis of methane hazard in longwall N-12 in seam 329/1, 329/1-2 in ‘Krupiński’ Coal Mine, in which on 5.05.2011 took place methane ignition, allowed to determine factors forming methane hazard in this longwall while taking into consideration location of longwall parcel relative to previous mining in this seam. Occurring discrepancies between total amount of methane emitted to longwall N-12 and forecast value indicate circumstances of additional inflow of methane from outside of its environment. Confirmation of such methane flow are results of calculations of distribution of the field of aerodynamic potentials in workings contouring mined out longwall N-14 and mining of longwall N-12, as well as, being a relevant particularity, results of methane bearing determination on coal pillar separating post-exploitation goaf of both longwalls. The article emphasizes the necessity of taking into account, at the stage of designing longwalls, ventilation conditions and the influence of the field of aerodynamic potentials on the possibility of goaf gases flow which may contribute to the increase of methane hazard.

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Mokienko, Valerij M. "Biblical Expressions in A. N. Ostrovsky’s Plays". SibScript 26, n.º 1 (22 de febrero de 2024): 1–12. http://dx.doi.org/10.21603/sibscript-2024-26-1-1-12.

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In 2023, Russia celebrates the 200th anniversary of Alexander N. Ostrovsky, the famous playwright who portrayed Russia in the epoch of serfdom. The author used the method of continuous sampling to harvest lexical intertextualisms from A. N. Ostrovsky’s plays, as well as the methods of linguistic culturological analysis, interpretation, linguacultural commentary, and systematizing to describe the material. Biblical expressions in A. N. Ostrovsky’s plays are numerous but remain understudied. However, they play an important semantic and linguacultural role in that they render the text a bookish style. Some personages demonstrate the symbolism of biblical words as dominants of their worldview. Quite often, biblical expressions are incomprehensible, archaic, or semantically random, thus revealing poor education. The article focuses on one-lexeme biblical expressions. They could be divided into two groups: 1) proper names, e.g., Jared, Herod, Judas, Lazarus, etc., and related phraseological units, e.g., to sing Lazarus, i.e. to lament or complain; 2) common nouns with a special symbolism in the text, e.g., expanse, vigil, fasting, abstinence, covenant, grace, goodness, bounty, ordeal, brimstone, etc. Each example is provided with comments on their biblical source and the functional characteristics in the context.

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Ikikardes, Nazli Yildiz, Jihyun Hwang y Daeyeoul Kim. "Arithmetic convolution sums derived from eta quotients related to divisors of 6". Open Mathematics 20, n.º 1 (1 de enero de 2022): 341–65. http://dx.doi.org/10.1515/math-2022-0031.

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Abstract The aim of this paper is to find arithmetic convolution sums of some restricted divisor functions. When divisors of a certain natural number satisfy a suitable condition for modulo 12, those restricted divisor functions are expressed by the coefficients of certain eta quotients. The coefficients of eta quotients are expressed by the sine function and cosine function, and this fact is used to derive formulas for the convolution sums of restricted divisor functions and of the number of divisors. In the sine function used to find the coefficients of eta quotients, the result is obtained by utilizing a feature with symmetry between the divisor and the corresponding divisor. Let N , r N,r be positive integers and d d be a positive divisor of N N . Let e r ( N ; 12 ) {e}_{r}\left(N;\hspace{0.33em}12) denote the difference between the number of 2 N d − d \frac{2N}{d}-d congruent to r r modulo 12 and the number of those congruent to − r -r modulo 12. The main results of this article are to find the arithmetic convolution identities for ∑ a 1 + ⋯ + a j = N ( ∏ i = 1 j e ˆ ( a i ) ) {\sum }_{{a}_{1}+\cdots +{a}_{j}=N}({\prod }_{i=1}^{j}\hat{e}\left({a}_{i})) with e ˆ ( a i ) = e 1 ( a i ; 12 ) + 2 e 3 ( a i ; 12 ) + e 5 ( a i ; 12 ) \hat{e}\left({a}_{i})={e}_{1}\left({a}_{i};\hspace{0.33em}12)+2{e}_{3}\left({a}_{i};\hspace{0.33em}12)+{e}_{5}\left({a}_{i};\hspace{0.33em}12) and j = 1 , 2 , 3 , 4 j=1,2,3,4 . All results are obtained using elementary number theory and modular form theory.

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Korniłowicz, Artur y Karol Pąk. "Vieta’s Formula about the Sum of Roots of Polynomials". Formalized Mathematics 25, n.º 2 (1 de julio de 2017): 87–92. http://dx.doi.org/10.1515/forma-2017-0008.

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Summary In the article we formalized in the Mizar system [2] the Vieta formula about the sum of roots of a polynomial anxn + an−1xn−1 + ··· + a1x + a0 defined over an algebraically closed field. The formula says that $x_1 + x_2 + \cdots + x_{n - 1} + x_n = - {{a_{n - 1} } \over {a_n }}$ , where x1, x2,…, xn are (not necessarily distinct) roots of the polynomial [12]. In the article the sum is denoted by SumRoots.

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Dobija, Lech, Jean-Baptiste Lechauve, Didier Mbony-Irankunda, Anne Plan-Paquet, Arnaud Dupeyron y Emmanuel Coudeyre. "Smartphone applications are used for self-management, telerehabilitation, evaluation and data collection in low back pain healthcare: a scoping review". F1000Research 11 (7 de mayo de 2024): 1001. http://dx.doi.org/10.12688/f1000research.123331.2.

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Background Smartphone use has grown in providing healthcare for patients with low back pain (LBP), but the literature lacks an analysis of the use of smartphone apps. This scoping review aimed to identify current areas of smartphone apps use for managing LBP. We also aimed to evaluate the current status of the effectiveness or scientific validity of such use and determine perspectives for their potential development. Methods We searched PubMed, PEDro and Embase for articles published in English up to May 3rd, 2021 that investigated smartphone use for LBP healthcare and their purpose. All types of study design were accepted. Studies concerning telemedicine or telerehabilitation but without use of a smartphone were not included. The same search strategy was performed by two researchers independently and a third researcher validated the synthesis of the included studies. Results We included 43 articles: randomised controlled trials (RCTs) (n=12), study protocols (n=6), reliability/validity studies (n=6), systematic reviews (n=7), cohort studies (n=4), qualitative studies (n=6), and case series (n=1). The purposes of the smartphone app were for 1) evaluation, 2) telerehabilitation, 3) self-management, and 4) data collection. Self-management was the most-studied use, showing promising results derived from moderate- to good-quality RCTs for patients with chronic LBP and patients after spinal surgery. Promising results exist regarding evaluation and data collection use and contradictory results regarding measurement use. Conclusions This scoping review revealed a notable interest in the scientific literatures regarding the use of smartphone apps for LBP patients. The identified purposes point to current scientific status and perspectives for further studies including RCTs and systematic reviews targeting specific usage.

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McLeod, Tamara C. Valovich y Candace Leach. "Psychometric Properties of Self-Report Concussion Scales and Checklists". Journal of Athletic Training 47, n.º 2 (1 de marzo de 2012): 221–23. http://dx.doi.org/10.4085/1062-6050-47.2.221.

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Reference/Citation: Alla S, Sullivan SJ, Hale L, McCrory P. Self-report scales/checklists for the measurement of concussion symptoms: a systematic review. Br J Sports Med. 2009;43 (suppl 1):i3–i12. Clinical Question: Which self-report symptom scales or checklists are psychometrically sound for clinical use to assess sport-related concussion? Data Sources: Articles available in full text, published from the establishment of each database through December 2008, were identified from PubMed, Medline, CINAHL, Scopus, Web of Science, SPORTDiscus, PsycINFO, and AMED. Search terms included brain concussion, signs or symptoms, and athletic injuries, in combination with the AND Boolean operator, and were limited to studies published in English. The authors also hand searched the reference lists of retrieved articles. Additional searches of books, conference proceedings, theses, and Web sites of commercial scales were done to provide additional information about the psychometric properties and development for those scales when needed in articles meeting the inclusion criteria. Study Selection: Articles were included if they identified all the items on the scale and the article was either an original research report describing the use of scales in the evaluation of concussion symptoms or a review article that discussed the use or development of concussion symptom scales. Only articles published in English and available in full text were included. Data Extraction: From each study, the following information was extracted by the primary author using a standardized protocol: study design, publication year, participant characteristics, reliability of the scale, and details of the scale or checklist, including name, number of items, time of measurement, format, mode of report, data analysis, scoring, and psychometric properties. A quality assessment of included studies was done using 16 items from the Downs and Black checklist1 and assessed reporting, internal validity, and external validity. Main Results: The initial database search identified 421 articles. After 131 duplicate articles were removed, 290 articles remained and were added to 17 articles found during the hand search, for a total of 307 articles; of those, 295 were available in full text. Sixty articles met the inclusion criteria and were used in the systematic review. The quality of the included studies ranged from 9 to 15 points out of a maximum quality score of 17. The included articles were published between 1995 and 2008 and included a collective total of 5864 concussed athletes and 5032 nonconcussed controls, most of whom participated in American football. The majority of the studies were descriptive studies monitoring the resolution of concussive self-report symptoms compared with either a preseason baseline or healthy control group, with a smaller number of studies (n = 8) investigating the development of a scale. The authors initially identified 20 scales that were used among the 60 included articles. Further review revealed that 14 scales were variations of the Pittsburgh Steelers postconcussion scale (the Post-Concussion Scale, Post-Concussion Scale: Revised, Post-Concussion Scale: ImPACT, Post-Concussion Symptom Scale: Vienna, Graded Symptom Checklist [GSC], Head Injury Scale, McGill ACE Post-Concussion Symptoms Scale, and CogState Sport Symptom Checklist), narrowing down to 6 core scales, which the authors discussed further. The 6 core scales were the Pittsburgh Steelers Post-Concussion Scale (17 items), Post-Concussion Symptom Assessment Questionnaire (10 items), Concussion Resolution Index postconcussion questionnaire (15 items), Signs and Symptoms Checklist (34 items), Sport Concussion Assessment Tool (SCAT) postconcussion symptom scale (25 items), and Concussion Symptom Inventory (12 items). Each of the 6 core scales includes symptoms associated with sport-related concussion; however, the number of items on each scale varied. A 7-point Likert scale was used on most scales, with a smaller number using a dichotomous (yes/no) classification. Only 7 of the 20 scales had published psychometric properties, and only 1 scale, the Concussion Symptom Inventory, was empirically driven (Rasch analysis), with development of the scale occurring before its clinical use. Internal consistency (Cronbach α) was reported for the Post-Concussion Scale (.87), Post-Concussion Scale: ImPACT 22-item (.88–.94), Head Injury Scale 9-item (.78), and Head Injury Scale 16-item (.84). Test-retest reliability has been reported only for the Post-Concussion Scale (Spearman r = .55) and the Post-Concussion Scale: ImPACT 21-item (Pearson r = .65). With respect to validity, the SCAT postconcussion scale has demonstrated face and content validity, the Post-Concussion Scale: ImPACT 22-item and Head Injury Scale 9-item have reported construct validity, and the Head Injury Scale 9-item and 16-item have published factorial validity. Sensitivity and specificity have been reported only with the GSC (0.89 and 1.0, respectively) and the Post-Concussion Scale: ImPACT 21-item when combined with the neurocognitive component of ImPACT (0.819 and 0.849, respectively). Meaningful change scores were reported for the Post-Concussion Scale (14.8 points), Post-Concussion Scale: ImPACT 22-item (6.8 points), and Post-Concussion Scale: ImPACT 21-item (standard error of the difference = 7.17; 80% confidence interval = 9.18). Conclusions: Numerous scales exist for measuring the number and severity of concussion-related symptoms, with most evolving from the neuropsychology literature pertaining to head-injured populations. However, very few of these were created in a systematic manner that follows scale development processes and have published psychometric properties. Clinicians need to understand these limitations when choosing and using a symptom scale for inclusion in a concussion assessment battery. Future authors should assess the underlying constructs and measurement properties of currently available scales and use the ever-increasing prospective data pools of concussed athlete information to develop scales following appropriate, systematic processes.

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Ionescu, C. E., C. Popescu, M. Agache, G. Dinache y C. Codreanu. "AB0348 DEPRESSION IN RHEUMATOID ARTHRITIS: PREVALENCE AND PHENOTYPIC CHARACTERISTICS - A SINGLE CENTER EXPERIENCE". Annals of the Rheumatic Diseases 82, Suppl 1 (30 de mayo de 2023): 1358.1–1358. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4310.

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BackgroundPsychiatric comorbidities are frequent extra-articular manifestations in rheumatoid arthritis (RA) and depression is the most common [1]. A 2013 study estimated that 16.8 % of RA patients suffer from major depressive disorder, being more prevalent than diabetes, Parkinson’s disease or cancer [2-3]. Patients with RA have constitutional symptoms, frequently encountered in depression, like fatigue, weight loss, insomnia and lack of appetite. The overlap of depression in inflammatory immune mediated diseases is recognized for some time [4]. Studies show that immune mediated inflammation affects and modulates neurogenesis, neurotransmission, neuroendocrine activity and neuroplasticity [5]. Depression has important effects on RA patients: worse prognosis, pain, fatigue, functional deficit, more comorbidities, higher rate of mortality, increased healthcare resource utilization and lowered quality of life [6].ObjectivesThe scope of this article is to highlight the importance of managing depression in RA. The primary objective was to estimate the prevalence of depression in a cohort of RA patients. The secondary objective was to describe the phenotypic characteristics of RA patients with depression.MethodsRA patients from the Center of Rheumatic Diseases in Bucharest were included in the study if they were at least 18 years-old and if they had two or three follow-ups, after 2019. The protocol included collection of demographical, clinical and biological data. Prevalence of depression is derived from patients’ medical history, known depression. Demographical characteristics and RA phenotype were compared between the two groups. Disease activity was estimated with DAS28 and its components, tender joint count, swollen joint count, CRP and were followed over time to compare disease activity between patients with known depression and patients without depression.ResultsWe collected data from 203 patients with RA, among whom 37 were known with depression, generating a prevalence of 18.2%. A meta-analysis from 2013 reported that 16.8 % patients with RA suffer from a major depression disorder [1]. Most of the patients with depression were women (87.2%). Female sex is a potential risk factor for depression [7]. The prevalence of active smoking among the depression subgroup was higher (8.1%, 1.8%, p = 0.041). Depression is a known risk factor for negative behaviors like smoking [8]. Patients had a longer disease duration (in median, 13 years compared to 10 years, p = 0.059) and also the seropositivity prevalence was lower. In 2022 a correlation between depression and seronegative RA was found [9]. DAS28 and the components of DAS28 were higher in the depression RA subgroup; DAS28 was higher at all time points (p < 0.001). Higher tender joint count was expected (p < 0.001), but swollen joint count was also higher among depressive RA patients (p < 0.001), as well as CRP (p = 0.009, Figure 1).Figure 1.Median CRP levels as three time points among depressive and non-depressive RA patients (ANCOVA)ConclusionDepression is prevalent among RA patients and it has an important impact on the quality of life; so depressive symptoms should be addressed in clinical practice. The correlation between the prognosis of rheumatic disease and depression is strong, regardless of the direction of causality. The assessment of depression could be a psychomarker for assessing RA prognosis. DAS28 is used to make therapeutic decisions, so given that depression scores increase DAS28, it follows that they also influence therapeutic decisions.References[1] Morf H et al.Clin Rheumatol2021, 40(5):1779-1787.[2] Overman CL et al.Arthritis Care Res (Hoboken) 2014, 66(5):671-678.[3] Jamshidi T et al.Open Access Rheumatol2019, 11:53-59.[4] Nerurkar L et al.Lancet Psychiatry2019, 6(2):164-173.[5] Muller N et al.Mol Psychiatry2007, 12(11):988-1000.[6] Yilmaz V et al.Eur J Rheumatol2017, 4(2):127-132.[7] Kim SY et al.Rheumatology (Oxford) 2020 Aug 1;59(8):1889-1897.[8] Englbrecht M et al.PLoS One2019, 14(5):e0217412.[9] Kwiatkowska B et al.Reumatologia2018, 56(4):219-227.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

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Dobija, Lech, Jean-Baptiste Lechauve, Didier Mbony-Irankunda, Anne Plan-Paquet, Arnaud Dupeyron y Emmanuel Coudeyre. "Smartphone applications are used for self-management, telerehabilitation, evaluation and data collection in low back pain healthcare: a scoping review". F1000Research 11 (6 de septiembre de 2022): 1001. http://dx.doi.org/10.12688/f1000research.123331.1.

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Background: Technological developments have accelerated notably in the field of telecommunications in the last few decades. Smartphone use has grown in providing healthcare for patients with low back pain (LBP), but the literature lacks an analysis of the use of smartphone apps. This scoping review aimed to identify current areas of smartphone apps use for managing LBP. We also aimed to evaluate the current status of the effectiveness or scientific validity of such use and determine perspectives for their potential development. Methods: We searched PubMed, PEDro and Embase for articles published in English up to May 3rd, 2021 that investigated smartphone use for LBP healthcare and their purpose. All types of study design were accepted. Studies concerning telemedicine or telerehabilitation but without use of a smartphone were not included. The same search strategy was performed by two researchers independently and a third researcher validated the synthesis of the included studies. Results: We included 43 articles: randomised controlled trials (RCTs) (n=12), study protocols (n=6), reliability/validity studies (n=6), systematic reviews (n=7), cohort studies (n=4), qualitative studies (n=6), and case series (n=1). The purposes of the smartphone app were for 1) evaluation, 2) telerehabilitation, 3) self-management, and 4) data collection. Self-management was the most-studied use, showing promising results derived from moderate- to good-quality RCTs for patients with chronic LBP and patients after spinal surgery. Promising results exist regarding evaluation and data collection use and contradictory results regarding measurement use. Conclusions: This scoping review revealed a growing scientific literature regarding the use of smartphone apps for LBP patients. The identified purposes point to current scientific status and perspectives for further studies including RCTs and systematic reviews targeting specific usage. Caution should be taken to monitor the impact of smartphone-related compulsive behaviour.

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Moumade, Samia, Aurélie Hemonnet-Goujot y Pierre Valette-Florence. "Activisme de la marque : les rôles de la légitimité de la marque et de la distance psychologique dans la relation entre le consommateur et la marque". Décisions Marketing N° 113, n.º 1 (3 de abril de 2024): 17–42. http://dx.doi.org/10.3917/dm.113.0017.

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• Objectifs Selon la théorie de la relation entre le consommateur et la marque, cette recherche vise à découvrir les mécanismes par lesquels les consommateurs approuvent, désapprouvent ou ignorent les campagnes d’activisme de marque d’un point de vue affectif et cognitif. • Méthodologie Cette recherche analyse deux stratégies d’activisme de marque, l’une sociale et l’autre environnementale. Elle est basée sur un protocole d’étude qualitative (36 participants), utilisant la technique de l’album en ligne avec 24 répondants, enrichie par 12 entretiens semi-directifs. • Résultats Cette étude révèle : un mécanisme émotionnel, la distance psychologique, et un mécanisme cognitif, la légitimité de la marque. Cette recherche met en évidence les trois piliers de la légitimité (morale, cognitive et pragmatique). De plus, si la marque est perçue comme trop éloignée de la cause, les consommateurs se sentent détachés de la marque et remettent en cause sa légitimité. • Implications managériales Ces résultats suggèrent des moyens d’atténuer les effets négatifs et d’améliorer l’impact positif des campagnes d’activisme de marques en (1) renforçant les stratégies de légitimation de la marque et (2) en réduisant la distance psychologique entre les consommateurs et la cause soutenue par les marques. • Originalité Cet article s’appuie sur la conceptualisation de la dualité des représentations mentales des consommateurs pour offrir une meilleure compréhension de la relation entre le consommateur et la marque dans le cas de marques réelles.

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Carleton, R. Nicholas, Gregory P. Krätzig, Shannon Sauer-Zavala, J. Patrick Neary, Lisa M. Lix, Amber J. Fletcher, Tracie O. Afifi et al. "Étude de la Gendarmerie royale du Canada : protocole d’enquête prospective sur les facteurs de risque et de résilience en matière de santé mentale". Promotion de la santé et prévention des maladies chroniques au Canada 42, n.º 8 (agosto de 2022): 360–76. http://dx.doi.org/10.24095/hpcdp.42.8.02f.

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Les membres de la Gendarmerie royale du Canada (GRC), comme l’ensemble du personnel de la sécurité publique, sont fréquemment exposés à des événements potentiellement traumatiques sur le plan psychologique qui contribuent à la survenue de blessures de stress posttraumatique. Le peu de travaux de recherche disponibles sur le sujet limite l’étude de ces blessures. Le présent article décrit l'étude de la GRC, qui fait partie des efforts concertés que la GRC a déployés pour réduire les blessures de stress posttraumatique en améliorant l'accès aux évaluations, aux traitements et aux formations fondés sur des données probantes, le recrutement des participants, ainsi que les développements de l'étude de la GRC à ce jour. L’étude de la GRC a été conçue pour : 1) élaborer et mettre en place un système d’évaluations annuelles, mensuelles et quotidiennes fondées sur des données probantes et en évaluer l’effet; 2) évaluer les associations entre les variables démographiques et les blessures de stress posttraumatique; 3) évaluer de manière longitudinale les différences individuelles associées aux blessures de stress posttraumatique; 4) intégrer au Programme de formation des cadets de la GRC des compétences permettant d’atténuer de façon proactive les blessures de stress posttraumatique et 5) évaluer l’effet de laformation renforcée (FR) par rapport à la formation standard (FS). Les participants à la FS (n = 480) et à la FR (n = 480) sont évalués avant et après la formation, ainsi que chaque année pendant cinq ans à compter de la date de leur déploiement; ils répondent également à de courts sondages mensuels et quotidiens. Les résultats de l'étude de la GRC devraient être bénéfiques pour la santé mentale de tous les participants, pour la GRC et pour le personnel de la sécurité publique, car ils contribueront à réduire les blessures de stress posttraumatique de tous ceux qui servent la population.

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Pratsiovytyi, M. V., Ya V. Goncharenko, I. M. Lysenko y S. P. Ratushniak. "Continued $\mathbf{A_2}$-fractions and singular functions". Matematychni Studii 58, n.º 1 (31 de octubre de 2022): 3–12. http://dx.doi.org/10.30970/ms.58.1.3-12.

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In the article we deepen the metric component of theory of infinite $A_2$-continued fractions $[0;a_1,a_2,...,a_n,...]$ with a two-element alphabet $A_2=\{\frac12,1\}$, $a_n\in A_2$ and establish the normal property of numbers of the segment $I=[\frac12;1]$ in terms of their $A_2$-representations: $x=[0;a_1,a_2,...,a_n,...]$. It is proved that almost all (in the sense of the Lebesgue measure) numbers of segment $I$ in their $A_2$-representations use each of the tuples of elements of the alphabet of arbitrary length as consecutive digits of the representation infinitely many times. This normal property of the number is effectively used to prove the singularity of the function $f(x=[0;a_1,a_2,...,a_n,...])=e^{\sum\limits_{n=1}^{\infty}(2a_n-1)v_n},$where $v_1+v_2+...+v_n+...$ is a given absolutely convergent series, when function $f$ is continuous (which is the case only if $v_n=\frac{v_1(-1)^{n-1}}{2^{n-1}}$, $v_1\in R$).

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Koçyiğit, Burhan Fatih y Ahmet Akyol. "ANALYSIS OF RETRACTED PUBLICATIONS FROM KAZAKHSTAN". Central Asian Journal of Medical Hypotheses and Ethics 3, n.º 2 (4 de agosto de 2022): 111–18. http://dx.doi.org/10.47316/cajmhe.2022.3.2.04.

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Introduction: Retraction is a mechanism to prevent the dissemination of erroneous, misleading, or biased data and information. Various factors can cause retraction. In this article, we focused on Kazakhstan data and aimed to present an analysis of retracted publications from Kazakhstan. Methods: Data for this descriptive cross-sectional article were obtained from the 'Retraction Watch’ database without time restriction. Among the country selections, 'Kazakhstan,' 'Tajikistan,' 'Uzbekistan,' 'Kyrgyzstan,' and 'Turkmenistan' were chosen, and the number of retracted articles was recorded. For detailed analysis, Kazakhstan data were focused on and further analyses were performed on Kazakhstan data. Article title, authors, time interval (in days) from publication to retraction, date of retraction, source of publication, subject area of publication, publication type, and retraction reason were recorded in an Excel file. Results: The number of retracted publications was detected as 64 from Kazakhstan, 49 from Tajikistan, 17 from Uzbekistan, 12 from Kyrgyzstan, and 1 from Turkmenistan. Kazakhstan data were as follows: The median time interval between publication date and retraction date was 475 (46 - 2074) days. Retraction reasons were listed as: Plagiarism (n = 22), peer review issues (n = 21), duplication (n = 11), author disagreements and conflict (n = 5), error (n = 5), fraud (n = 2), ethical issues ( n = 1), publication issues (n = 1), and unknown (n = 1). The three areas with the most retracted articles were engineering (n = 22), education (n = 21), and technology (n = 12). Conclusion: Kazakhstan was first among the five Central Asian countries in terms of the number of retracted publications. Plagiarism, peer review issues, and duplication were at the forefront of the retraction reasons. There is a need for approaches to increase the knowledge of researchers in Kazakhstan about the retraction reasons and ethical research conditions.

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Nguyen, Bryan, Chirag Acharya, Supawit Tangpanithandee, Jing Miao, Pajaree Krisanapan, Charat Thongprayoon, Omar Amir, Michael A. Mao, Wisit Cheungpasitporn y Prakrati C. Acharya. "Efficacy and Safety of Plasma Exchange as an Adjunctive Therapy for Rapidly Progressive IgA Nephropathy and Henoch-Schönlein Purpura Nephritis: A Systematic Review". International Journal of Molecular Sciences 24, n.º 4 (16 de febrero de 2023): 3977. http://dx.doi.org/10.3390/ijms24043977.

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Patients with IgA nephropathy (IgAN), including Henoch-Schönlein purpura nephritis (HSP), who present with rapidly progressive glomerulonephritis (RPGN) have a poor prognosis despite aggressive immunosuppressive therapy. The utility of plasmapheresis/plasma exchange (PLEX) for IgAN/HSP is not well established. This systematic review aims to assess the efficacy of PLEX for IgAN and HSP patients with RPGN. A literature search was conducted using MEDLINE, EMBASE, and through Cochrane Database from inception through September 2022. Studies that reported outcomes of PLEX in IgAN or HSP patients with RPGN were enrolled. The protocol for this systematic review is registered with PROSPERO (no. CRD42022356411). The researchers systematically reviewed 38 articles (29 case reports and 9 case series articles) with a total of 102 RPGN patients (64 (62.8%) had IgAN and 38 (37.2%) had HSP). The mean age was 25 years and 69% were males. There was no specific PLEX regimen utilized in these studies, but most patients received at least 3 PLEX sessions that were titrated based on the patient’s response/kidney recovery. The number of PLEX sessions ranged from 3 to 18, and patients additionally received steroids and immunosuppressive treatment (61.6% of patients received cyclophosphamide). Follow-up time ranged from 1 to 120 months, with the majority being followed for at least 2 months after PLEX. Among IgAN patients treated with PLEX, 42.1% (n = 27/64) achieved remission; 20.3% (n = 13/64) achieved complete remission (CR) and 18.7% (n = 12/64) partial remission (PR). 60.9% (n = 39/64) progressed to end-stage kidney disease (ESKD). Among HSP patients treated with PLEX, 76.3% (n = 29/38) achieved remission; of these, 68.4% (n = 26/38) achieved CR and 7.8% achieved (n = 3/38) PR. 23.6% (n = 9/38) progressed to ESKD. Among kidney transplant patients, 20% (n = 1/5) achieved remission and 80% (n = 4/5) progressed to ESKD. Adjunctive plasmapheresis/plasma exchange with immunosuppressive therapy showed benefits in some HSP patients with RPGN and possible benefits in IgAN patients with RPGN. Future prospective, multi-center, randomized clinical studies are needed to corroborate this systematic review’s findings.

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Setiawan, Achdiar Redy y Murni Yusoff. "Islamic Village Development Management: A Systematic Literature Review". Jurnal Ekonomi Syariah Teori dan Terapan 9, n.º 4 (31 de julio de 2022): 467–81. http://dx.doi.org/10.20473/vol9iss20224pp467-481.

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ABSTRAK Pengelolaan pembangunan desa islami adalah konsep pembangunan desa yang memiliki karakteristik tercapainya tujuan pembangunan sosial ekonomi yang berdimensi holistik, seimbang antara aspek material dan spiritual. Penelitian ini bertujuan untuk mengkaji pembahasan kajian-kajian terdahulu secara sistematis tentang konsep dan praktik pengelolaan pembangunan desa dalam perspektif islam. Dalam rangka melakukan review publikasi artikel secara sistematis, riset ini menggunakan standar protokol RAMESES. Hasil penelitian ini terbagi menjadi dua tema utama, yaitu peran dan fungsi lembaga keuangan mikro syariah dalam pembangunan desa dan Lembaga Swadaya Masyarakat dalam pengelolaan pembangunan desa. Tema pertama menghasilkan tiga subtema: praksis keuangan mikro syariah di Bangladesh, Malaysia, dan Indonesia. Tema kedua menghasilkan satu subtema yaitu peranan Pesantren dalam mendukung pengelolaan pembangunan desa. Hasilnya memberikan landasan untuk mengisi ruang-ruang yang belum dimasuki untuk membangun pengelolaan pembangunan desa yang komprehensif berdasarkan prinsip atau nilai Islam yang ideal. Kata kunci: Islami, Pengelolaan Pembangunan Desa, Systematic Literature Review. ABSTRACT Islamic village development management is a village development concept that has the characteristics of achieving socio-economic development goals with a holistic dimension, balanced between material and spiritual aspects. This study aims to systematically review the discussion of previous studies on the concepts and practices of village development management from an Islamic perspective. To conduct the article review systematically, this research was carried out using the RAMESES protocol standard. The results of this study are divided into two main themes, namely the role and function of Islamic microfinance institutions in village development and non-governmental organizations in managing village development. The first theme produces three sub-themes: the practice of Islamic microfinance in Bangladesh, Malaysia, and Indonesia. The second theme resulted in a sub-theme, namely Pesantren's role in supporting the management of village development. The results provide a foundation to fill in the gaps that have not been entered to build a comprehensive village development management based on ideal Islamic principles or values. Keywords: Islamic, Village Development Management, Systematic Literature Review. REFERENCES Abdullah, M. F., Amin, M. R., & Ab Rahman, A. (2017). Is there any difference between Islamic and conventional microfinance? Evidence from Bangladesh. International Journal of Business and Society, 18(S1), 97–112. Adejoke, A.-U. G. (2010). Sustainable microfinance institutions for poverty reduction: Malaysian experience. OIDA International Journal of Sustainable Development, 2(4), 47–56. http://dx.doi.org/10.2139/ssrn.1666023 Akhter, W., Akhtar, N., & Jaffri, S. K. A. (2009). 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