Bibliografías temáticas / Antiproliferative properties

Literatura académica sobre el tema "Antiproliferative properties"

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Publicado: 18 de mayo de 2024

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Artículos de revistas sobre el tema "Antiproliferative properties"

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Yoshizawa, Yuko, Kenji Sakurai, Satoru Kawaii, Masayoshi Asari, Junichi Soejima y Noboru Murofushi. "Comparison of Antiproliferative and Antioxidant Properties among Nineteen Apple Cultivars". HortScience 40, n.º 5 (agosto de 2005): 1204–7. http://dx.doi.org/10.21273/hortsci.40.5.1204.

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Aqueous ethanol extracts prepared from 19 apple (Malus ×domestica Borkh.) cultivars were studied to explore their antiproliferative activity. Half of them showed strong inhibition on proliferation of human leukemic HL-60 cells, while the others were weak. Total polyphenols, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and total anthocyanins were measured and the results indicated that the antiproliferative activity was more strongly correlated to the polyphenols and radical scavenging activity than to the anthocyanin content. Several polyphenols in `Jonathan' were identified and quantified by high-performance liquid chromatography (HPLC) analysis. Among those compounds found during HPLC, catechin and epicatechin seemed partially responsible for HL-60 antiproliferation. A careful examination on parentage of the apple cultivars tested revealed that `Jonathan' and its progeny showed high antiproliferation toward HL-60. This is the first observation about the relationship between antiproliferative activity and parentage of apples, and the information would be useful to create new apple cultivars that posses more anticancer potential.
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Liu, Xiaoling y Mei-Lin Go. "Antiproliferative properties of piperidinylchalcones". Bioorganic & Medicinal Chemistry 14, n.º 1 (enero de 2006): 153–63. http://dx.doi.org/10.1016/j.bmc.2005.08.006.

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Kessler, Romain, Serge Dumont, Emmanuel Weitzenblum y Philippe Poindron. "Antiproliferative Properties of Human Alveolar Macrophages". Respiration 65, n.º 5 (1998): 363–68. http://dx.doi.org/10.1159/000029296.

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Çankaya, Nevin. "Synthesis of Hydrogels Containing Halloysite and Investigation of Antiproliferative Activity". Advances in Clinical Toxicology 8, n.º 3 (2023): 1–10. http://dx.doi.org/10.23880/act-16000274.

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In this study, superabsorbent hydrogels containing halloysite clay, biopolymer (CMC, carboxymethyl cellulose), acrylamide (AM) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) were synthesized and characterized by free radical polymerization method. Then, the cytotoxic effect of hydrogels on MDA-MB-231 breast cancer cells was evaluated. According to the findings, hydrogels were successfully synthesized and their cytotoxic properties were supported by in vitro studies. In order for these hydrogels to be used as a drug delivery system, their potential properties need to be supported by further research such as in vivo.
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YOSHIZAWA, Yuko, Kenji SAKURAI, Satoru KAWAII, Junichi SOEJIMA y Noboru MUROFUSHI. "Antiproliferative and Antioxidant Properties of Crabapple Juices". Food Science and Technology Research 10, n.º 3 (2004): 278–81. http://dx.doi.org/10.3136/fstr.10.278.

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Recio, Mari-Carmen, Rosa-María Giner y Salvador Máñez. "Immunmodulatory and Antiproliferative Properties of Rhodiola Species". Planta Medica 82, n.º 11/12 (25 de mayo de 2016): 952–60. http://dx.doi.org/10.1055/s-0042-107254.

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Gescher, Andreas. "Antiproliferative properties of phorbol ester tumour promoters". Biochemical Pharmacology 34, n.º 15 (agosto de 1985): 2587–92. http://dx.doi.org/10.1016/0006-2952(85)90552-0.

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Trindade, Cristiano, André Luiz Mendes Juchem, Temenouga N. Guecheva, Iuri M. de Oliveira, Priscila dos Santos Silveira, José Eduardo Vargas, Renato Puga, Claudia Ó. Pessoa y João A. P. Henriques. "Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties". Oxidative Medicine and Cellular Longevity 2019 (24 de octubre de 2019): 1–14. http://dx.doi.org/10.1155/2019/2510936.

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Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established. In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and promising applications. Diphenyl ditelluride (DPDT), an organic tellurium derivate, showed antioxidant, antigenotoxic, antimutagenic, and anticancer properties. The antioxidant and prooxidant properties of DPDT are complex and depend on experimental conditions, which may explain the contradictory reports of these properties. In addition, DPDT may exert its effects through different pathways, including distinct ones to those responsible for chemotherapy resistance phenotypes: transcription factors, membrane receptors, adhesion, structural molecules, cell cycle regulatory components, and apoptosis pathways. This review aims to present recent advances in our understanding of the biological effects, therapeutic potential, and safety of DPDT treatment. Moreover, original results demonstrating the cytotoxic effects of DPDT in different mammalian cell lines and systems biology analysis are included, and emerging approaches for possible future applications are inferred.
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Sousa, André, Paula Araújo, Joana Azevedo, Luís Cruz, Iva Fernandes, Nuno Mateus y Victor de Freitas. "Antioxidant and antiproliferative properties of 3-deoxyanthocyanidins". Food Chemistry 192 (febrero de 2016): 142–48. http://dx.doi.org/10.1016/j.foodchem.2015.06.108.

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Boratyński, Przemysław J., Joanna Gałęzowska, Kamil Turkowiak, Artur Anisiewicz, Rafał Kowalczyk y Joanna Wietrzyk. "Triazole Biheterocycles fromCinchonaAlkaloids: Coordination and Antiproliferative Properties". ChemistrySelect 3, n.º 32 (29 de agosto de 2018): 9368–73. http://dx.doi.org/10.1002/slct.201801810.

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Tesis sobre el tema "Antiproliferative properties"

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Tiwari, Bipransh Kumar. "Studies on antiproliferative and antibacterial properties of some quinazoline-4(3H)-ones and their dimers". Thesis, University of North Bengal, 2016. http://ir.nbu.ac.in/hdl.handle.net/123456789/2573.

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Dale, Ian L. "Investigation of the antiproliferative properties of tumour promoting phorbol esters and related compounds". Thesis, Aston University, 1989. http://publications.aston.ac.uk/12560/.

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Tumour promoting phorbol esters such as 12-0-tetradecanoylphorbol-13-acetate (TPA) exert a multitude of biological effects on many cellular systems, many of which are believed to be mediated via the activation of the enzyme protein kinase C (PKC). TPA and other biologically active phorbol esters inhibited the proliferation of the A549 human lung carcinoma cell line. However, after 5-6 days culture in the continued presence of the phorbol ester cells began to proliferate at a rate similar to that of untreated cells. Resistance to TPA was lost following subculturing, although subculture in the presence of 10 nM TPA for more than 9 weeks resulted in a more resistant phenotype. The selection of a TPA-resistant subpopulation was not responsible for the observed resistance. The antiproliferative properties of other PKC activators were investigated. Mezerein induced the same antiproliferative effects as TPA but synthetic diacylglycerols (DAGs), the presumed physiological ligands of PKC, exerted only a non-specific cytotoxic influence on growth. Bryostatins 1 and 2 were able to induce transient growth arrest of A549 cells in a manner similar to phorbol esters at nanomolar concentrations, but at higher concentrations blocked both their own antiproliferative action and also that of phorbol esters and mezerein. Fourteen compounds synthesized to mimic features of the phorbol ester pharmacophore and/or DAGs did not mimic the antiproliferative properties of TPA in A549 cells and exerted only a DAG-like non-specific cytotoxicity at high concentrations. The subcellular distribution and activity of PKC was determined following partial purification by non-denaturing polyacrylamide gel electrophoresis. Treatment with TPA, mezerein or bryostatins resulted in a concentration-dependent shift of PKC activity from the cytosol to cellular membranes within 30 min. Significant translocation was not observed on treatment with DAGs. Chronic exposure of cells to TPA caused a time- and concentration dependent down-regulation of functional PKC activity. A complete loss of PKC activity was also observed on treatment with growth-inhibitory concentrations of bryostatins. No PKC activity was detected in cells resistant to the growth-inhibitory influence of TPA. Measurement of intracellular Ca2+ concentrations using A549 cells cultured on Cytodex 1 microcarrier beads revealed that TPA, mezerein and the bryostatins induced a similar rapid rise in intracellular Ca2+ levels.
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Friedli, Alexandra Anita. "Targeting the L1 cell adhesion molecule in cancer : mechanisms involved in the antiproliferative properties of anti-L1 antibodies /". Zürich : ETH/PSI, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17859.

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Vaz, Josiana A. "Study of antioxidant, antiproliferative and apoptosis-inducing properties of wild mushrooms from the Northeast of Portugal". Doctoral thesis, 2012. http://hdl.handle.net/10198/13154.

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Mushrooms are known as a powerful source of bioactive compounds including antioxidants, inhibitors of human tumour cell lines growth, inducers of apoptosis and enhancers of immunity. Indeed, many pre-clinical studies have been conducted in human tumour cell lines and in some cases a number of compounds isolated from mushrooms have followed to clinical trials. The Northeast of Portugal is one of the European regions with higher wild mushrooms diversity. However, to our knowledge, no studies had been conducted so far to verify their bioactivities. The main aim of this work was the evaluation of the bioactive properties (antioxidant properties and growth inhibitory potential on human tumour cell lines) of wild edible mushrooms collected in the Northeast of Portugal. Once properly identified, methanolic, ethanolic and boiling water extracts were prepared from thirty eight wild mushroom species collected in that region. Chemical characterization was obtained by high performance liquid chromatography (HPLC) coupled to a photodiode array detector (DAD) or to a refraction index detector (RI). Antioxidant activity assays were carried out in those extracts, including evaluation of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals scavenging capacity, reducing power and inhibition of β-carotene bleaching. Extract-induced cell growth inhibition was assessed with the sulforhodamine B assay in four human tumour cell lines (NCI-H460 - lung cancer, MCF-7 -breast cancer, HCT-15 -colon cancer and AGS - gastric cancer). The effects on cell cycle profile and apoptosis were evaluated by flow cytometry and the effect on the expression levels of proteins related to cell cycle and apoptosis was further investigated by Western blotting. Three wild edible mushroom species revealed growth inhibitory activity in the studied human tumour cell lines: Clitocybe alexandri ethanolic extract, Lepista inversa methanolic extract and Suillus collinitus methanolic extract. C. alexandri ethanolic extract induced an S-phase cell cycle arrest and increased the percentage of apoptotic cells, in the NCI-H460 cell line. The analysed mushroom species also provided interesting antioxidant potential, mainly the boiling water extract of L. inversa which showed the highest DPPH radical scavenging activity, reducing power and β-carotene bleaching inhibition. S. collinitus methanolic extract induced a slight increase in the number of cells in G1, with a concomitant decrease in the percentage of cells in the S phase of the cell cycle and an increase in the percentage of apoptotic cells, in the MCF-7 cell line. The combined use of the S. collinitus methanolic extract and etoposide caused a greater decrease in the percentage of cell growth, when compared to either of them used individually, indicating the potential benefit of this combination. The tested extracts were chemically characterized and protocatechuic, p-hydroxybenzoic, p-coumaric and cinnamic acids were the main compounds identified on the phenolic (methanolic and ethanolic) extracts, while mannitol, trehalose and arabinose were the main sugars found in the polysaccharidic (boiling water) extracts after hydrolysis. The individual compounds identified in the extracts were submitted to a screening of tumour cells growth inhibitory activity, but only the phenolic acids and a related compound, cinnamic acid, presented activity. This compound was found to be the most potent one regarding cell growth inhibition in the NCI-H460 cell line. The effect of the individual and combined treatment with the identified compounds was also evaluated. Cinnamic and protochatequic acids caused a statistically significantly reduction in the number of viable cells. In addition, p-hydroxybenzoic acid did not show any significantly reduction in the viable cell number. Nevertheless, it was verified that the concomitant use of the three compounds provided the strongest decrease in the viable cell number, suggesting a possible concomitant effect of those compounds. Overall, the present work has contributed to further understand the bioactive potential of wild edible mushrooms from the Northeast of Portugal. This study allowed to identify some species with antioxidant or tumour cell growth inhibitory potential.
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Vaz, Josiana Adelaide. "Study of Antioxidant, Antiproliferative and Apoptosis-inducing properties of wild mushrooms from the Northeast of Portugal". Doctoral thesis, 2012. https://repositorio-aberto.up.pt/handle/10216/74289.

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Vaz, Josiana Adelaide. "Study of Antioxidant, Antiproliferative and Apoptosis-inducing properties of wild mushrooms from the Northeast of Portugal". Tese, 2012. https://repositorio-aberto.up.pt/handle/10216/74289.

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Fiorillo, Marco, Diego Sisci y Annarita Cappello. "New natural statin-like compounds with anticholesterolemic and antiproliferative properties: "in vitro and in vivo studies"". Thesis, 2015. http://hdl.handle.net/10955/1543.

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Dottorato di Ricerca in Biochimica Cellulare ed Attività dei Farmaci in Oncologia, Ciclo XXVIII, a.a. 2015-2016
Il rischio di malattia coronaria è aumentato negli individui che mostrano elevata concentrazione di colesterolo nelle lipoproteine plasmatiche a bassa densità (LDL). E’ stato dimostrato che l’inibizione del 3-idrossi-3-metilglutaril-CoA reduttasi (HMGR), enzima che catalizza la conversione di HMG-CoA in mevalonato (MVA), tappa limitante la velocità di biosintesi del colesterolo, è l’approccio più efficace per la diminuzione plasmatica di LDL e la riduzione del tasso di eventi cardiovascolari. Come parte di un meccanismo compensatorio, alla deplezione di colesterolo nel fegato, dovuto all’inibizione dell’enzima HMGR, segue l’aumento della produzione di recettori per le LDL e il successivo smaltimento di LDL dalla circolazione sistemica. Gli inibitori di HMGR rappresentano la classe di farmaci più efficaci e maneggevoli per la riduzione della concentrazione di LDL. Sebbene le statine siano gli inibitori di HMGR più largamente prescritti, sono associate a spiacevoli effetti collaterali quali severa miopatia e perdita della memoria statinoassociata. In questo contesto l’identificazione di nuovi composti statino-simili, che agiscono come inibitori di HMGR, risulta utile per superare le limitazioni già descritte. E’ stato dimostrato che alcuni composti naturali, che si ritrovano nella nostra dieta, hanno proprietà terapeutiche e farmacologiche. In particolare studi condotti in seguito a somministrazione cronica di succo di alcune specie di Citrus hanno confermato che questa strategia influenza positivamente i livelli plasmatici dei lipidi e può essere associata alla riduzione del rischio di malattia coronarica. Durante questo lavoro di tesi , l’attenzione è stata rivolta allo studio di due flavonoidi, statino-simili, (brutieridina e melitidina) estratte dal bergamotto (Citrus bergamia), ma presenti anche in altre specie del genere Citrus. Come molecola di riferimento è stata considerata la statina commerciale più prescritta nell’uomo, la simvastatina. Gli esperimenti sono stati condotti utilizzando una frazione arricchita delle due molecole (EF) ed una purificata (BMF), al 99%. I composti testati, sono stati isolati e caratterizzati in maniera esaustiva, mediante spettrometria di massa e risonanza magnetica, dal gruppo di ricerca del Prof. G. Sindona (Dip.to di Chimica, Università della Calabria). In particolare, si è valutata “in vivo”, l’attività ipocolesterolemica e ipolipidemica delle frazioni oggetto di studio. In primo luogo è stato ottenuto un modello animale ipercolesterolemico, in seguito al trattamento degli animali (ratti) con una dieta opportuna. Successivamente, sul modello ottenuto è stato monitorato il metabolismo del colesterolo, mediante la valutazione del livello di espressione dei geni codificanti l’enzima HMGR ed il recettore delle LDL, sia a livello di trascritto che a livello proteico. Il metabolismo dei trigliceridi, invece, è stato monitorato valutando il livello di trascritto e di proteina del gene che codifica per il principale enzima della sintesi degli acidi grassi e quindi dei trigliceridi, il gene FASN. Inoltre sono stati valutati i livelli di colesterolo e di trigliceridi nel fegato e nel sangue ed è stata determinata sia l’attività di HMGR che quella di due enzimi coinvolti nella lipogenesi, in quanto responsabili della produzione di NADPH, utilizzato per la sintesi degli acidi grassi e del colesterolo, enzima malico e isocitrato deidrogenasi. I risultati ottenuti hanno evidenziato, nei ratti trattati con BMF, una riduzione dei livelli di colesterolo e dei trigliceridi, sia a livello epatico che sierico, tale decremento è risultato essere ancora più evidente nei ratti trattati con EF, rispetto ai controlli ipercolesterolemici. Dalla valutazione dei livelli di trascrizione di due principali proteine coinvolte nel metabolismo del colesterolo, HMGR ed LDLR e dell'enzima principale della biosintesi degli acidi grassi, FASN, è emerso chiaramente che il comportamento di BMF è simile a quello della simvastatina, uno dei farmaci ipocolesterolemici più utilizzati. Infine, dalla valutazione dell’attività degli enzimi HMGR, isocitrato deidrogenasi citoplasmatica ed enzima malico, negli epatociti degli animali trattati con le due frazioni rispetto a quella evidenziata negli epatociti dei ratti controllo, è stata riscontrata un’inibizione, anche in questo caso, paragonabile a quella osservata per i ratti trattati con simvastatina. Attraverso lo studio condotto è stato dimostrato che le due molecole estratte dal bergamotto, brutieridina e melitidina, sono dotate di attività ipocolesterolemica, dovuta all’azione inibitoria esercitata nei confronti dell’enzima HMGR. L’interesse scientifico inoltre, è stato quello di valutare “in vitro”, l’aspetto anti-proliferativo ed antinfiammatorio dei due flavonoidi studiati. Infatti, in letteratura è riportato che le statine sintetiche riducono la proliferazione di un’ampia varietà di tipi cellulari, “in vitro”, inducendo l’arresto del ciclo cellulare nella fase G1. Questa sperimentazione è stata condotta su cellule di carcinoma mammario umano, MCF7, utilizzando la frazione purificata (BMF) e comparando i risultati con quelli ottenuti dopo trattamento di cellule della stessa linea con simvastatina (profarmaco precedentemente utilizzato per gli studi “in vivo”) e pravastina. Il lavoro svolto ha previsto, in primo luogo, la creazione di una linea tumorale, stabile, che fosse in grado di over-esprimere il gene HMGCR (MCF-7-HMGCR), utilizzando un metodo di trasfezione virale; successivamente è stata valutata l’attività proliferativa delle cellule tumorali (MCF-7); delle cellule tumorali trasfettate con il gene HMGCR (MCF-7-HMGCR) e di quelle epiteliali non tumorali (fibroblasti hTERT-BJ1), dopo trattamento con BMF, pravastatina e simvastatina. I risultati ottenuti hanno dimostrato che alte concentrazioni di BMF svolgono un’azione antiproliferativa meno elevata di quella riscontrata con concentrazioni più basse di simvastatina. Tuttavia è doveroso sottolineare che mentre BMF e pravastatina non inibiscono la proliferazione cellulare, nelle cellule non tumorali, la simvstatina è risultata essere tossica anche a basse concentrazioni. Mediante analisi con XFe96 Seahorse Analyzersi è effettuata la valutazione metabolica delle linee cellulari MCF-7, MCF-7-HMGCR, hTERT-BJ1. I risultati ottenuti hanno evidenziato un’aumentata respirazione mitocondriale (OCR) nella linea MCF-7-HMGCR rispetto alla MCF-7; nessuna differenza in termini di funzione glicolitica (ECAR) è stata, invece, riscontrata tra le due linee cellulari. Inoltre, la respirazione mitocondriale, in cellule MCF-7-HMGCR, dopo trattamento con BMF, ha evidenziato una riduzione della produzione di ATP e una diminuzione della respirazione massimale e della capacità respiratoria cellulare. Infine, le analisi OCR su cellule hTERT-BJ1 dopo trattamento con BMF, pravastatina e simvastatina hanno sottolineato una riduzione della respirazione mitocondriale minima, nelle cellule trattate con pravastatina; tale riduzione è risultata essere più marcata nelle cellule trattate con simvastatina. Nessuna differenza è stata, invece, riscontrata nelle cellule trattate con BMF. Questi risultati hanno confermato una leggera tossicità nelle cellule hTERT-BJ1 trattate con pravastatina ed una marcata tossicità in quelle trattate con simvastatina, a differenza delle cellule trattate con BMF. Inoltre, l’indagine effettuata su diversi pathways, implicati nella proliferazione cellulare e nell’infiammazione, ha evidenziato un potenziale effetto antinfiammatorio e antiossidante di BMF, come sottolineato da un aumento della risposta antiossidante e di quella immunitaria regolate dall’interferone I, da una diminuzione della risposta infiammatoria mediata dall’interferone-gamma e da una down-regolazione della via infiammatoria regolata dal gene STAT3, in cellule MCF-7, trattate con BMF. Il trattamento con BMF ha determinato, inoltre, la down-regolazione di due pathways coinvolti nella proliferazione tumorale e nella formazione di CSCs (cancer stem cells), regolati da Notch e Wnt. Questi risultati hanno portato ad indagare su un’eventuale coinvolgimento di BMF, nella formazione di mammospheres e a dimostrare, dopo trattamento con BMF, un decremento nella efficienza di formazione di mammospheres, dose dipendente, più marcato nelle cellule che over-esprimono l’enzima HMGCR. Successivamente, è stata riscontrata, per BMF, la capacità di ridurre lo stress ossidativo, la formazione di radicali liberi e la successiva risposta pro-infiammatoria, come evidenziato dalla diminuizione dell’espressione delle citochine pro-infiammatorie, regolata dal complesso proteico NF-kB e dalla diminuizione dell’espressione dei fattori inducibili l’ipossia, regolata dal gene HIF, riscontrate in cellule hTERT-BJ1, trasfettare con i gene reporter Nf-KB e HIF e trattate con BMF. Infine è stato valutato l’effetto antinfiammatorio ed antiossidante della frazione purificata di brutieridina e melitidina; dai risultati ottenuti è stato possibile evincere una riduzione dei fattori di stimolazione, coinvolti nella formazione dei granulociti e dei macrofagi, in cellule MCF-7 trattate con pravastatina ed, in egual misura, in quelle trattate con BMF. Anche la produzione di IL-8, in cellule trattate con BMF, ha mostrato un decremento, di poco inferiore a quello riscontrato in cellule trattate con pravastatina. Infine la riduzione di cancer stem cells (CSC) è stata valutata tramite l’impiego di un marker specifico (ALDH) che ha permesso di isolare la popolazione ALDEFLUOR-positiva relativa alla popolazione staminale, in cellule MCF7. Dopo trattamento con BMF e pravastatina, è emersa una netta diminuzione della popolazione ALDEFLUOR-positiva, nella linea cellulare MCF7. Pertanto, l’aggiunta di colesterolo (prodotto della biosintesi del mevalonato) al mezzo cellulare, in presenza di BMF e/o pravastatina , non ha cambiato la percentuale di riduzione della popolazione di CSCs. Al contrario l’aggiunta di mevalonato al mezzo di coltura, ha riportato sia il numero di mammospheres che la percentuale della popolazione di CSCs ai valori del controllo. Questi risultati hanno permesso di indicare la BMF come un composto con scarsa tossicità e capace di prevenire la crescita tumorale, l’espansione tumorale mediata da fattori pro-infiammatori e la fomazione di CSCs. L’impiego della BMF in concomitanza ai canonici chemioterapici, potrebbe migliorare l’effetto degli stessi e diventare un nuovo target drug nella terapia add-on.
Università della Calabria
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Sah, Baidya Nath Prasad. "Identification of bioactive peptides produced in synbiotic yoghurt having anticancer properties". Thesis, 2016. https://vuir.vu.edu.au/32311/.

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Cancer is the most widely recognized reason for human deaths globally. Conventional anticancer therapies, including chemotherapy and radiation, are very costly and induce severe side effects on the individual. The discovery of anticancer compounds including dairy-derived peptides may thus be a better alternative for cancer prevention and management. Anticancer peptides exist in the amino acid chain of milk proteins and can be generated during proteolytic activities such as gastrointestinal digestion or food processing including fermentation by lactic acid bacteria (LAB) and probiotics. However, proteolytic capacity of these bacteria is strain specific. The study was conducted to establish proteolytic activity of Lactobacillus (L.) acidophilus (ATCC® 4356™), L. casei (ATCC® 393™) and L. paracasei subsp. paracasei (ATCC® BAA52™) in yogurt. Crude peptides were separated by ultra-high centrifugation and tested for antioxidant and antimutagenic activities. The degree of proteolysis highly correlated with these bioactivities, and its value (11.91 %) for samples containing all the cultures was double that of the control. Liberated peptides showed high radical scavenging activities with 1,1- diphenyl-2-picrylhydrazyl and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid), IC50 1.51 and 1.63 mg/ml respectively and strong antimutagenicity (26.35 %). These probiotics enhanced the generation of bioactive peptides in yogurt.
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Libros sobre el tema "Antiproliferative properties"

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Dale, Ian Lester. Investigation of the antiproliferative properties of tumour promoting phorbol esters and related compounds. Birmingham: Aston University. Department of Pharmaceutical Sciences, 1989.

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Capítulos de libros sobre el tema "Antiproliferative properties"

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Wong, Jack Ho, Tzi Bun Ng, Evandro Fei Fang y He-Xiang Wang. "Defense Proteins with Antiproliferative and Antimicrobial Activities from Fungi and Bacteria". En Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds, 359–73. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6214-5_24.

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Vijayalakshmi, K. "Antiproliferative Potential of Medicinal Plants—an Evaluation by in Vivo, in Vitro, and in Silico Approaches". En Ethnomedicinal Plants with Therapeutic Properties, 345–81. Includes bibliographical references and index.: Apple Academic Press, 2019. http://dx.doi.org/10.1201/9780429487767-20.

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Dayal, Bishambar, Vineela Reddy Yannamreddy, Ritesh Amin, Michael A. Lea y Athula B. Attygalle. "Bioactive Compounds inMoringa oleifera: Isolation, Structure Elucidation, and Their Antiproliferative Properties". En ACS Symposium Series, 203–19. Washington, DC: American Chemical Society, 2013. http://dx.doi.org/10.1021/bk-2013-1129.ch013.

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Mphahlele, Malose Jack, Marole Maria Maluleka y Mmakwena Modlicious Mmonwa. "Synthesis of Heterocycle-Appended 4-Aminoquinazolines with Antiproliferative Properties and Potential to Inhibit Tyrosine Kinases". En Chemistry for a Clean and Healthy Planet, 307–16. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-20283-5_18.

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Tubić, Biljana, Bojan Marković y Tibor Sabo. "Discovery of Membrane Permeability, Pharmacokinetics Properties and Mechanism of Action for Analogs of Ethylenediamine-N,N′-di-2-(3-Cyclohexyl)Propionic Acid and 1,3-Propandiamine-N,N′-di-2-(3-Cyclohexyl)Propionic Acid with Antiproliferative Activity Using In Vitro and In Silico Methods". En IFMBE Proceedings, 357–69. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-17971-7_55.

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Osafo, Newman, Yaw Duah Boakye, Christian Agyare, Samuel Obeng, Judith Edem Foli y Prince Amankwaah Baffour Minkah. "African Plants with Antiproliferative Properties". En Natural Products and Cancer Drug Discovery. InTech, 2017. http://dx.doi.org/10.5772/intechopen.68568.

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Garg, Hari G., Robert J. Linhardt y Charles A. Hales. "Influence of Heparin Chemical Modifications on its Antiproliferative Properties". En Chemistry and Biology of Heparin and Heparan Sulfate, 513–32. Elsevier, 2005. http://dx.doi.org/10.1016/b978-008044859-6/50019-8.

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Mehra, Vishu y Isha Lumb. "Recent Synthetic and Biological Advances in Anti-Cancer Ferrocene-Analogues and Hybrids". En Advances in Organic Synthesis, 1–39. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815040791123180003.

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Cancer is among the most severe risks to the global human population. The enduring crisis of drug-resistant cancer and the limited selectivity of anticancer drugs are significant roadblocks to its control and eradication, requiring the identification of new anticancer entities. The stable aromatic nature, reversible redox properties, and low toxicity of ferrocene revolutionized medicinal organometallic chemistry, providing us with bioferrocene compounds with excellent antiproliferative potential, which has been the focus of persistent efforts in recent years. Substituting the aryl/heteroaryl core for ferrocene in an organic molecule alters its molecular characteristics, including solubility, hydro-/lipophilicity, as well as bioactivities. Ferrocifen (ferrocene analogues of hydroxytamoxifen) has shown antiproliferative potential in both hormone-dependent (MCF-7) and hormone-independent (MDA-MB-231) breast cancer cells. It is now in pre-clinical trials against malignancies. These entities operate through various targets, some of which have been revealed and activated in response to product concentrations. They also react to the cancer cells by diverse mechanisms that can work in concert or in isolation, depending on signaling pathways that promote senescence or death. The behavior of ferrocene-containing hybrids with a range of anticancer targets is explained in this chapter.
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D’Ascenzio, Melissa. "The Role of Flavonoids and other Selected (Poly) Phenols in Cancer Prevention and Therapy: A Focus on Epigenetics". En Flavonoids and Phenolics, 384–489. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815079098122010015.

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The importance of diet in determining the incidence of chronic illnesses such as diabetes, cardiovascular disorders, neurodegenerative diseases, and cancer has inspired extensive research on the role of individual dietary components in chemoprevention. Flavonoids and (poly)phenols have often been identified as the ideal candidates for these types of studies, as they represent large classes of natural products that are widely available in fruit and vegetables. In this chapter, we will discuss the antiproliferative properties of flavonols, flavanols, flavones, isoflavones, anthocyanins, curcuminoids and resveratrol derivatives, with a particular focus on their ability to interfere with epigenetic processes and modulate gene expression. We will look at the challenges encountered during the optimisation of the pharmacokinetic and pharmacodynamic properties of these natural products and, where possible, we will define structure-activity relationships.<br>
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Kryukov, Lavr, Andrey Vorotyntsev y Aleksandr Shirokov. "Tuberoid Orchids: Micropropagation for Biomedical Applications". En Micropropagation of Medicinal Plants, 212–31. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815196146124010012.

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The article presents the developed protocol for the propagation of tuberous orchids and their organs. The protocol allows for the cultivation of materials for reintroduction, restoration of disturbed populations and biomedical research. A phytochemical analysis of this plant group was conducted for the first time, confirming their medicinal properties. Micropropagation was employed to achieve this objective. The study focused on nine species of tuberous orchids from the Orchidaceae family: Dactylorhiza traunsteineri, D. maculata, D. fuchsii, D. incarnata, D. urvilleana, D. baltica, Gymnadenia conopsea, G. conopsea f. gigantea and Orchis militaris. The results demonstrated that these species contain chemical substances with potential physiological activities. For example, squalene exhibited positive effects such as antifungal, anticancer, antibacterial, antioxidant, and others. Additionally, other identified chemical substances demonstrated antiproliferative and proapoptotic activities against colon cancer, as well as antibacterial, anti-inflammatory, antioxidant, antitumoral, and antifungal properties.
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Actas de conferencias sobre el tema "Antiproliferative properties"

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Nasibova, Tohfa, István Zupkó, Judit Hohmann, Attila Horváth, Anita Barta y Hiba Faroug Muddather. "Chemical composition and antiproliferative properties of Peganum harmala". En 4th International Symposium of Young Researchers on Medicinal Plants and Natural Product Research. Szeged: Institute of Pharmacognosy, University of Szeged, Faculty of Pharmacy, 2023. http://dx.doi.org/10.14232/syrmpnpr.2023.9.

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Yusuf, Siti Nur Aishah Mat, Joe Yi Chan, Tasnim Ahmad Zaini y Hock Ing Chiu. "Antiproliferative properties of the synthesised Mariposa Christia vespertilionis silver nanoparticles". En THE PROCEEDING OF THE 1ST INTERNATIONAL CONFERENCE OF CHEMICAL SCIENCE, ENGINEERING AND TECHNOLOGY. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0117541.

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Keyes, Joseph T., Bruce R. Simon y Jonathan P. Vande Geest. "Transport in Pulsatile Axisymmetric Stented Arterial Models From Location-Dependent Variations in Permeability and Mechanical Properties". En ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53998.

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Drug-eluting stents (DESs) perform their antiproliferative effects through the use of localized drug delivery. The delivery may be computationally modeled to determine efficacy of the DES-tissue system and utilizes coupled convective and diffusive transport. Since the movement of solutes through the wall is via the coupled effects of convective and diffusive transport, the relative influence of these factors provides insight into the governing forces of localized DES drug delivery [1].
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Garbuz, Olga, Ion Toderas, Ianina Ulchina, Vasile Graur, Nadejda Railean y Аurelian Gulea. "The Antiproliferative, Antioxidant Activities and Toxicity of Mixed-Ligand Amine-Containing Copper (II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(Prop-2-En-1-Yl) Hydrazinecarbothioamide". En Xth International Conference of Zoologists. Institute of Zoology, Republic of Moldova, 2021. http://dx.doi.org/10.53937/icz10.2021.20.

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Five compounds 2-(2-Hydroxybenzylidene)-N-(prop-2-en1-yl)hydrazinecarbothioamide (H2L), bis[μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl) phenolatoS,N,O:O] diaquadicopper (II) nitrate (1), bis [μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl)phenolato-S,N,O:O]d iimidazoldicopper(II) nitrate (2), bis[μ2-2-({2-[(prop-2en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper( II) nitrate hexahydrate (3), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl) phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds towards cancer cell lines HeLa, RD and normal cell line MDCK have been investigated. The tested compounds demonstrated high antioxidant and antiproliferative, selective activities towards cancer cells. Direct toxic evaluation of compounds was performed by Daphnia magna bioassay.
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Xiao, Min, Jin Wang, Yan Lu, Duane D. Miller y Wei Li. "Abstract B20: Design, synthesis and SAR studies of novel survivin inhibitors with potent antiproliferative properties". En Abstracts: AACR Special Conference on Advances in Melanoma: From Biology to Therapy; September 20-23, 2014; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.mel2014-b20.

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Velcheva, Vyara, Kaspar Hegetschweiler, Angel Ugrinov, Georgi Momekov y Galina Gencheva. "Platinum(IV) complexes of the 1,3,5-triamino-1,3,-trideoxy-cis-inositol- synthesis: structure and antiproliferative properties". En RAD Conference. RAD Centre, 2023. http://dx.doi.org/10.21175/rad.abstr.book.2023.23.4.

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Adams, John, Lei Shen, Jigisha Patel, Xaxier Norel, Lucie Clapp y Dominic Behan. "The non-prostanoid IP receptor agonist, APD811 (ralinepag) has potent antiproliferative and vasorelaxant properties in human pulmonary artery". En ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa2378.

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Manara, Maria Cristina, Mirco Fanelli, Stefano Amatori, Clara Guerzoni, Lorena Landuzzi, Pier-Luigi Lollini, Luca Giorgi, Vieri Fusi y Katia Scotlandi. "Abstract 2768: Molecular properties and antiproliferative activity against tumor cells of a new poly-alkylamino-bis-maltolic synthetic molecule (maltonis)." En Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2768.

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Hussein, Ola, Feras Alali, Ala‐Eddin Al Mustafa y Ashraf Khalil. "Development of Novel Chalcone Analogs as Potential Multi-Targeted Therapies for Castration-Resistant Prostate Cancer". En Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0114.

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Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of patients ultimately progress to a lethal form of the disease, castration-resistant prostate cancer (CRPC). Therefore, the objective of this study was to discover and develop novel treatment modalities for CRPC. Chalcones are among the highly attractive scaffolds being investigated for their antitumor activities. A library of 26 chalcone analogs were designed, synthesized and evaluated as potential therapies for CRPC. The design was guided by in-silico ADMET prediction in which analogs with favorable drug-likeness properties were prioritized. The new compounds were synthesized, purified and characterized by extensive structural elucidation studies. The compounds in vitro cytotoxicity was evaluated against two androgen receptor (AR)-negative prostate cancer cell lines (PC3 and DU145). Among the tested compounds, pyridine containing analogs (13, 15 and 16) showed potent antiproliferative activities with IC50 values ranging between 4.32-6.47 µM against PC3 and DU145 cell lines. Detailed biological studies of the lead molecule 16 revealed that it can significantly induce apoptosis through upregulation of Bax and downregulation of Bcl-2. In addition, compound 16 potently inhibited colony formation and reduced cell migration of AR-negative PCa cell lines (PC3 and DU145). The molecular pathway analysis showed that the anticancer activity of compound 16 is associated with blocking of ERK1/2 and Akt activities. Furthermore, compound 16 inhibited angiogenesis in the chick chorioallantoic membrane (CAM) model as compared to control. Structure-activity relationship study revealed that the cytotoxicity could dramatically improve via changing the methoxylation pattern by more than 2-folds (IC50 << 2.5 μM). These results indicate that pyridine-based chalcones could serve as promising lead molecules for the treatment of CRPC; thus, further in vitro and in vivo studies are warranted.
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Informes sobre el tema "Antiproliferative properties"

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Patil, Bhimanagouda S., Ron Porat, G. K. Jayaprakasha y K. N. C. Murthy. Optimization of Postharvest Storage Conditions to Maintain Fruit Quality and Health Maintaining Properties of Grapefruit. United States Department of Agriculture, enero de 2010. http://dx.doi.org/10.32747/2010.7613879.bard.

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Antioxidant activity of fruits is gaining wide interest among consumers due to its importance in counteracting oxidative stress, free radicals and preventing DNA damage. Oxygen radical absorbance capacity (ORAC) assay is one of the commonly used assays to measure the antioxidant activity, which is based on hydrogen atom transfer mechanism. Furocoumarins present in grapefruit are reported to have antiproliferative activity, induce GST activity, inhibit biofilm formation and increase bioavailability of drugs. In the present project ORAC values were measured of Star Ruby grapefruit undergone ethylene degreening treatment, cold storage and temperature conditioning treatment, and modified atmosphere packaging which were stored at different temperatures for prolonged period. In addition, furocoumarins were quantified in Star Ruby grapefruits from cold storage and conditioning experiment conducted in Israel. Conditioning treatment is practiced prior cold storage to reduce chilling injury in grapefruits during cold storage for prolonged period. Levels of 6,7-dihyrdoxy bergamottin decreased during storage period in all three treatments.
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