Tesis sobre el tema "Antigen-antibody reactions"
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Andersson, Kerstin. "Antigen-antibody reactions a study of functional structures and non-immunological interactions /". Lund : Dept. of Biochemistry, Lund University, 1995. http://catalog.hathitrust.org/api/volumes/oclc/39264530.html.
Texto completoThornton, Gail Marilyn. "Biolithography : selective joining using antibody-antigen reactions". Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/42816.
Texto completoIncludes bibliographical references (p. 211-212).
Biolithography is a contribution to the field of Solid Free Form Fabrication. Part production is based on selective joining using antibody- antigen reactions, where the selectively is based on the thermal sensitivity of such proteins. Antibodies and antigens can be chemically immobilized to a variety of substrate materials: polymeric, ceramic and metallic. In the present investigation, antibody coated 1 [mu]m polystyrene beads and antigen coated glass surface substrates, as well as, antigen solutions were used. Both antibodies and antigens were multivalent i.e. have more that one binding site for each other; thus, two antibody coated beads could be held together by one antigen. Selective deposition was demonstrated by thermally deactivating antigen coated onto glass and precipitating antibody coated beads. Bead deposition was selective to the regions of remaining active antigens; thus, revealing the defined deactivated region. Thermal deactivation of the antigen coated substrate was first demonstrated with a 90°C water jet and improved using an argon ion laser which produced line widths on the order of tens of microns. Selective definition of geometry was an extension of the coating process precipitating not one but two bead layers and linking beads using antigen in solution. The thermal deactivation mechanism was a modified 90°C water jet that had line width resolution on the order of millimeters. Line definition was on both antigen coated bases and bound bead bases; thus, thermal deactivation was effective on both immobilized antigen (glass) and antibody (bead). The selective deposition of antibody coated substrate was demonstrated by thermally deactivating immobilized antigens and antibodies on surface substrates. Definition resolution was dependent on the thermal deactivation mechanism used.
by Gail Marilyn Thornton.
S.M.
Tsui, Ka-kit y 徐家傑. "Seasonal variation of serum prostate-specific antigen levels in Hong Kong". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40738292.
Texto completoTsui, Ka-kit. "Seasonal variation of serum prostate-specific antigen levels in Hong Kong". Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40738292.
Texto completoLuo, Cheng-Ping. "Detection of antibody antigen reactions using surface acoustic wave and electrochemical immunosensors". [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971863121.
Texto completoMummert, Mark E. "Stability in antigenic reactivity of the major outer surface protein, OspA, in borrelia burgdorferi, during persistent infection in Syrian hamsters". Virtual Press, 1992. http://liblink.bsu.edu/uhtbin/catkey/845968.
Texto completoDepartment of Biology
陳磊碩 y Lui-sek Chan. "Chemical modification of immunoglobulins and the effects on antigen binding site affinity". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B29913378.
Texto completoChan, Lui-sek. "Chemical modification of immunoglobulins and the effects on antigen binding site affinity /". [Hong Kong] : University of Hong Kong, 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13731506.
Texto completoJohansson, Daniel X. "Expression and interaction studies of recombinant human monoclonal antibodies /". Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-137-1/.
Texto completoBarbar, Elisar Jamil. "Nuclear Magnetic Resonance Study of Antigen-Antibody Complexes, Including Sequence Specific Assignments and Structural Analysis of Neurophysin as an Antigen Model". PDXScholar, 1993. https://pdxscholar.library.pdx.edu/open_access_etds/1167.
Texto completoLiu, Ming-Sun. "Studies of a sperm acrosomal antigen recognized by HS-63 monoclonal antibody". Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/30996.
Texto completoMedicine, Faculty of
Obstetrics and Gynaecology, Department of
Graduate
Aversa, Gregorio Giuseppe Gerardo. "Production and characterization of monoclonal antibodies to human activation and memory T cell antigens". Thesis, The University of Sydney, 1990. http://hdl.handle.net/2123/18628.
Texto completoGoff, Randal D. "Structure-activity studies of glycosphingolipids as antigens of natural killer T cells /". Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1519.pdf.
Texto completoSchuman, Jason Tyler. "Structural and dynamical investigations of the interaction between the MUC1 tumor antigen and the humoral immune system : towards the design of a second generation cancer vaccine /". Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8613.
Texto completoBabakhani, Farah Kondori 1960. "IN VITRO PRODUCTION AND SPECIFICITY OF ANTI-DNA AUTO ANTIBODIES BY NEW ZEALAND BLACK/NEW ZEALAND WHITE F1 MICE". Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276471.
Texto completoKwong, Pearl Chu. "Characterization of an antigen-specific T helper cell clone and its products". Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/27366.
Texto completoScience, Faculty of
Microbiology and Immunology, Department of
Graduate
Grinstead, Jeffrey Scott. "Structural immunology of humoral and cellular recognition of a MUC1 breast cancer antigen /". Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8180.
Texto completoEichbaum, Quentin Gavin. "Antigenic mimicry and autoantibodies in rheumatic fever". Doctoral thesis, University of Cape Town, 1990. http://hdl.handle.net/11427/26296.
Texto completoGreen, Melanie Leslie Dawn. "The identification of novel autoantigens by means of serological screening of a cDNA expression library constructed from multiple sclerosis brain tissues". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0018/MQ54892.pdf.
Texto completoDe, Leon Ellen Jane Biotechnology & Biomolecular Sciences Faculty of Science UNSW. "Engineering antibodies against complex platelet antigens using phage display technology". Awarded by:University of New South Wales, 2007. http://handle.unsw.edu.au/1959.4/37009.
Texto completoGeorge, Dashwill Anton. "Validation and application of the ELISA technique for the detection of fish aero-antigens". Thesis, Peninsula Technikon, 2003. http://hdl.handle.net/20.500.11838/1484.
Texto completoIncreased seafood consumption due to its nutrition and promotion of a healthy diet has lead to more frequent reports of allergic reactions. In the seafood industry, workers are exposed to the antigens through inhalation of the vapours created during the seafood processing and cooking. Most seafood allergens are stable molecules, which are resistant to the effect of cooking and processing. The prevalence of occupational asthma varies from 7-36% among different groups of workers including seafood processing and fishmeal workers, fishermen and restaurant cooks (Jeebhay et al 2001). Purpose of Study: The purpose of the study is to determine total protein and the specific fish antigen concentrations in the environment by means of personal air sampling filters obtained from various categories of workers in the seafood processing industry. Objectives: • To determine the correlation between total protein concentrations and specific fish (pilchard and anchovy) antigen concentrations on personal air sampling filters using the linear response model of the standard curve. • To determine the correlation between total protein concentrations and specific fish (pilchard and anchovy) antigen concentrations on personal air sampling filters using the sigmoidal response model with a variable slope of the standard curve. • To identify the most efficient standard curve response model for fish antigen detection by comparing the percentage recovery of the linear standard curve response model and the sigmoidal standard curve response model. Methodology: A sample population of 195 samples was taken from workers in the seafood industry at the St. Helena Bay Fisheries and West Point Processors using personal air sampling pumps.
Otali, Dennis. "The combined effect of formalin fixation and individual steps in tissue processing on immunorecognition". Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2008r/otali.pdf.
Texto completoRogers, Todd H. "Receptor recognition and response of dendritic cells to biomaterials". Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37107.
Texto completoAltindis, Emrah. "Identification Of The New Immunogenic Proteins Of Bordetella Pertussis By Immunoproteomics". Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608320/index.pdf.
Texto completoLute, Kenneth D. "Costimulation and tolerance in T cell immunotherapy". Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1141850521.
Texto completoGolakai, Hawa Jande. "Identification of immune correlates of natural protection against tuberculosis in a population with a high incidence of latent infection". Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/21776.
Texto completoENGLISH ABSTRACT: Setting This study was conducted in the Tygerberg area of Cape Town in South Africa. Background A third of the world’s population is latently infected with Mycobacterium tuberculosis, and correlates of protection against progression to active disease urgently need to be identified to facilitate the development of an effective vaccine against the disease. The production of IFN-γ is recognised as an immune correlate of protection from tuberculosis, but other immune regulators have been implicated in playing a significant role in protective immunity. The aims of this project were three-fold: (i) to identify promising TB vaccine candidates by screening a panel of novel MTB antigens, by stimulating whole blood cultures in vitro with the novel proteins and quantifying the level of IFN-γ production, (ii) to identify other cytokines and chemokines that may be immune correlates of protection using the Luminex fluorescent bead-based technique and (iii) to compare the performance of the two techniques. Methods Antigen Screening study Whole blood of 57 adult and adolescent participants defined as latently infected individuals was stimulated with a panel of 78 novel TB-specific, DosR- or RD1-encoded antigens. The 7-day culture supernatants were used in IFN-γ ELISA to quantify the level of IFN-γ production. Luminex Assay study Whole blood culture supernatants of 15 HIV negative, TST positive adults were used in the Luminex LINCO 21-plex cytokine assay. This was done to determine which of 21 cytokines, that may be LTBI-associated cytokines, were produced after stimulation with 9 TB-specific recombinant antigens, and to quantify their level of expression. Results In the antigen screening study, it was found the majority of the 78 proteins tested were able to induce a positive IFN-γ response. The classic TB antigens were used as controls, and the frequency of responses was highest after stimulation with ESAT-6 and TesatCFP10 (80 – 85% of responders). Ten latency antigens elicited an IFN-γ response in 19 – 45% of participants, and five reactivation antigens stimulated a positive reaction in 15 – 48% of responders. The category of antigens that elicited the most frequent and highest responses overall was the resuscitation-promoting factors (Rpf). Over 30% of participants responded to all 5 Rpfs, and the level of responses were equally divided in the low and moderate-to-high levels, with an additional 5% of responses in the high (>1000pg/ml) range. In the Luminex study, the positive stimulant TesatCFP10 consistently induced expression of most cytokines. In addition latency antigens Rv1733c, Rv0569 and Rv2029c also induced moderate-to-high level cytokine expression. A Th1-biased cytokine profile was observed, with the preferential expression of pro-inflammatory and cell-mediated cytokines like IFN-γ, TNF-α, IP-10, MIP1-α and G-CSF being produced. Th2 cytokines IL-4, IL-5, IL-13 and eotaxin were very poorly expressed or were not expressed at detectable levels. A very strong induction of IL-6, IL-8 and MCP-1 was observed, but this cytokine/chemokine association suggested contamination of the recombinant antigens with bacterial endotoxins. Conclusion In this study of latently infected individuals, the pattern of response observed for both assays is largely a Th1-biased expression profile. The whole blood ELISA method is a well-established assay for quantifying IFN-γ in culture supernatants, and has proven to be effective here. This study has demonstrated, in humans with LTBI, immune recognition of these novel MTB-specific antigens as illustrated by the positive IFN-γ levels induced after stimulation. The multiplex technology is also a very versatile and sensitive assay, capable of detecting multiple analytes simultaneously in one sample. The multiplex has been valuable here in identifying some antigens as potential vaccine candidates, and a subset of cytokines as potential immune mediators and prognostic indicators in TB infection.
AFRIKAANSE OPSOMMING: Studie-area Hierdie studie was gedoen in die Tygerberg area van Kaapstad in Suid-Afrika. Agtergrond ‘n Derde van die wêreld se bevolking is latent geïnfekteer met Mycobacterium tuberculosis en korrelate van beskerming teen die siekte moet geïdentifiseer word om die ontwikkeling van ‘n effektiewe enstof te fasiliteer. Die produksie van IFN-γ is welbekend as ‘n immuunkorrelaat van beskerming teen tuberkulose (TB), maar ander immuunreguleerders speel ook ‘n belangrike rol in beskermende immuniteit. Die doelwitte van hierdie projek was drievoudig: (i) om belowende TB-entstof kandidate te identifiseer deur die sifting van ‘n paneel van nuwe MTB antigene mbv die in vitro stimulasie van volbloed kulture, ii) om ander sitokiene en chemokiene as immuunkorrelate van beskerming te identifiseer deur van die Luminex fluorescent bead-based tegniek gebruik te maak, en (iii) om die twee tegnieke te vergelyk op grond van hul prestasie as prognostiese of siftings metodes in latente infeksie. Metodes Antigeen siftings studie Volbloed van 57 volwasse en adolessente deelnemers, geïdentifiseer as latent geïnfekteerde individue, was gestimuleer met ‘n paneel van 78 nuwe TB-spesifieke DosR- or R-gekodeerde antigene. Die 7-dae kultuur supernatante was gebruik in ‘n IFN-γ ELISA om die hoeveelheid IFN-γ produksie the kwantifiseer. Luminex assay studie Volbloed kultuur supernatante van 15 HIV negatiewe, TST positiewe volwassenes was gebruik in die Luminex LINCO 21-plex cytokine assay. Dit was gedoen om die tipes en hoeveelheid ander LTBI-geassosieerde sitokienes te identifiseer wat geproduseer word na stimulasie met 9 TB-spesifieke rekombinante antigene. Resultate In die antigeen siftings studie is gevind dat die meerderheid van die 78 getoetste proteïene ‘n positiewe IFN-γ reaksie kon induseer. Vir die kontroles was die frekwensie van reaksies die hoogste na stimulasie met ESAT-6 en TesatCFP-10 (80 – 85% van reageerders). Tien latensie antigene was gereeld herken deur 19 – 45% van deelnemers en vyf reaktiverings-antigene het ‘n positiewe reaksie in 15 – 48% van reageerders gestimuleer. Die kategorie van antigene wat die meeste en hoogste response veroorsaak het, was die resusitasie-promoterende faktors (Rpf). Meer as 30% van deelnemers het op al 5 Rpfs gereageer en die vlak van reaksies was gelyk verdeel in die lae en matig-tot-hoog vlakke, met ‘n addisionele 5% van reaksies in die hoë (>1000pg/ml) reeks. In die Luminex studie het die positiewe stimulant TesatCFP-10 konsekwent die positiewe uitdrukking van die meeste sitokiene geïnduseer. Saam met dit het die latente antigene Rv1733c, Rv0569 en Rv2029c ook matige-toe-hoë vlakke van sitokien uitdrukking geïnduseer. ‘n Th1-gebaseerde sitokien profiel was waargeneem, met die begunstigde uitdrukking van pro-inflammatoriese en sel-gemedieerde sitokiene soos IFN-γ, TNF-α, IP-10, MIP1-α en G-CSF. Th2 sitokiene IL-4, IL-5, IL- 13 en eotaksien was of baie sleg uitgedruk of onder naspeurbare vlakke uitgedruk. ‘n Baie sterk induksie van IL-6, IL-8 en MCP-1 was waargeneem, maar hierdie sitokiene/chemokiene assosiasie stel moontlik kontaminasie van die rekombinante antigene met bakteriële endotoksiene voor. Samevatting Die reaksiepatroon wat in hierdie studie tussen die twee toetse waargeneem is, was grootliks ‘n Th1-gebaseerde uitdrukkingsprofiel vir latente infeksie met TB. Die volbloed ELISA metode is a betroubare gevestigde toets vir die kwantifisering van IFN-γ in kultuur supernatante, wat ook in hierdie studie bewys is om effektief te wees. Hierdie studie het gedemonstreer dat die nuwe TB-spesifieke antigene effektief positiewe IFN-γ response in mense met LTBI induseer. Die multipleks tegnologie is ook ‘n baie veelsydige en sensitiewe toets, wat in staat is om veelvoudige analite gelyktydig in een monster te kan opspoor. In hierdie studie was dit veral waardevol in die identifisering van ander moontlike antigene as prognostiese kandidate en sitokiene as immuunbemiddelaars in TB-infeksie.
KURAMOTO, GRACIELA B. "Estudo compartimental e dosimétrico do anti-CD20 marcado com 188Re". reponame:Repositório Institucional do IPEN, 2016. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26599.
Texto completoMade available in DSpace on 2016-08-25T11:05:49Z (GMT). No. of bitstreams: 0
A radioimunoterapia (RIT) faz uso de anticorpos monoclonais conjugados com radionuclídeos emissores α ou β-, ambos para terapia. O tratamento baseia-se na irradiação e destruição do tumor, preservando os órgãos normais quanto ao excesso de radiação. Radionuclídeos emissores β- como 90Y, 131I, 177Lu e 188Re, são úteis para o desenvolvimento de radiofármacos terapêuticos e, quando associados a AcM como o Anti-CD20 são importantes principalmente para o tratamento de Linfomas Não Hodgkins (LNH). 188Re (Eβ- = 2,12 MeV; Eγ= 155 keV; t1/2 = 16,9 h) é um radionuclídeo atrativo para RIT. O Centro de Radiofarmácia do IPEN possui um projeto que visa a produção do radiofármaco 188Re-Anti-CD20. Com isso,este estudo foi proposto para avaliar a eficácia desta técnica de marcação para tratamento em termos compartimentais e dosimétricos. O objetivo deste trabalho consistiu na compararação da marcação do AcM anti-CD20 com 188Re com a marcação do anticorpo com 90Y, 131I, 177Lu e 99mTc (pelas suas características químicas similares) e 211At, 213Bi, 223Ra e 225Ac. Através do estudo de técnicas de marcação relatadas em literatura, foi proposto um modelo compartimental para avaliação de sua farmacocinética e estudos dosimétricos, de alto interesse para a terapia. A revisão de dados publicados na literatura, possibilitou demonstrar diferentes procedimentos de marcação, rendimentos de marcação, tempo de reação, impurezas e estudos de biodistribuição. O resultado do estudo mostra uma cinética favorável para o 188Re, pelas suas características físicas e químicas frente aos demais radionuclídeos avaliados. O estudo compartimental proposto descreve o metabolismo do 188Re-anti-CD20 através de um modelo compartimental mamilar, que pela sua análise farmacocinética, realizada em comparação aos produtos marcados com emissores β-: 131I-antiCD20, 177Lu-anti-CD20, o emissor γ 99mTc-anti-CD20 e o emissor α 211At-Anti-CD20, apresentou uma constante de eliminação de aproximadamente 0,05 horas-1 no sangue do animal. A avaliação dosimétrica do 188Re-Anti-CD20 foi realizada através de duas metodologias: pelo método de Monte Carlo e pelo uso de uma fonte pontual β- através da Fórmula de Loevinger via programa Excel. Através da Fórmula de Loevinger fez-se a validação do método de Monte Carlo para a dosimetria do 188Re-Anti-CD20 e dos demais produtos. As doses e as taxas de doses obtidas pelos dois métodos foram avaliadas em comparação à dosimetria do 90Y-Anti-CD20, 131I-Anti-CD20 e do 177Lu-Anti-CD20, obtidas pela mesma metodologia. O estudo de dose foi realizado utilizando modelos matemáticos considerando um camundongo nude de 25g, simulando diferentes tamanhos de tumor e diferentes formas de distribuição do produto dentro do animal. De acordo com os resultados obtidos, pela energia de emissão β-, 188Re-Anti-CD20 apresenta maior deposição de energia para tumores volumosos em relação aos demais produtos avaliados. Em uma simulação com 100% do produto captado pelo tumor, 89% da dose total manteve-se absorvida pelo tumor, preservando a integridade de ógãos críticos como coração (2%), pulmões (5%), coluna (4%), fígado (0,014%) e rins (0,0007%). Em uma simulação onde há uma biodistribuição do produto no organismo do animal, 38% da dose total é absorvida pelo tumor e >3% é absorvida pela coluna. Nessa situação mais próxima da realidade, a extrapolação dos dados para um humano de 70kg, mostrou que a dose absorvida no tumor corresponde a cerca de 33%; na coluna 7% e o coração receberia uma dose de 35% do total. A análise compartimental e dosimétrica apresentada neste trabalho, realizada através do uso de um modelo animal para o 188Re-Anti-CD20 mostra que o produto desenvolvido e apresentado em literatura é candidato promissor para a RIT.
Tese (Doutorado em Tecnologia Nuclear)
IPEN/T
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
Gonzalez, Elfwing Olivia y Elin Nilsson. "Utvärdering av icke-invasiva metoder för diagnostik av Helicobacter pylori-infektion : En systematisk litteraturstudie". Thesis, Hälsohögskolan, Jönköping University, HHJ, Avd. för naturvetenskap och biomedicin, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-48758.
Texto completoHelicobacter pylori infection is one of the leading causes of ventricular pathologies. Reliable analytic methods are therefore crucial for the correct diagnosis and treatment of the infection. The aim of this study was to provide an overview of non-invasive diagnostic methods used for the detection of H. pylori and to evaluate which method is most suitable, considering its performance and the clinical condition of the patient. A systematic literature review was conducted, searching peer-reviewed research articles with inclusion and exclusion criteria on the databases PubMed and CINAHL. An assessment of the selected articles quality resulted in the inclusion of 20 articles. Overall, stool antigen tests had a sensitivity and specificity of 92,64% and 91,47% respectively, antibody tests 97,20% and 81,59% respectively, urea breath tests 91,40% and 91,70% respectively, and the polymerase chain reaction 75,45% and 98,30% respectively. Furthermore, conditions such as atrophic gastritis, intestinal metaplasia and gastrointestinal bleeding had a negative impact on the diagnostic accuracy of the methods. This study concluded that, regarding the methods performance, stool antigen tests are more suitable for detecting a H. pylori infection. With the mentioned clinical conditions, at least two non- invasive diagnostic methods should be used to ensure reliable results.
Jacob, Laurent. "Role immunogene d'une proteine de surface cellulaire au cours du lupus erythemateux dissemine". Paris 6, 1986. http://www.theses.fr/1986PA066541.
Texto completoNewman, Peter M. "Antibody and antigen in heparin-induced thrombocytopenia /". 1999. http://www.library.unsw.edu.au/~thesis/adt-NUN/public/adt-NUN20001214.161838/index.html.
Texto completoMaynard, Jennifer Anne 1974. "Engineering antibody therapeutics : approaches to neutralizing bacterial toxins". 2002. http://hdl.handle.net/2152/11127.
Texto completoMaynard, Jennifer Anne. "Engineering antibody therapeutics approaches to neutralizing bacterial toxins /". 2002. http://wwwlib.umi.com/cr/utexas/fullcit?p3114782.
Texto completoWilliams, David Collin. "A study of protein conformational dynamics in antigen : Antibody interactions /". 1997. http://wwwlib.umi.com/dissertations/fullcit/9738792.
Texto completoLin, Yu Ping y 林玉瓶. "Study the Applications of Antigen-Antibody Related Reactions in Analytical Magnetapheresis". Thesis, 2005. http://ndltd.ncl.edu.tw/handle/78372089670778989094.
Texto completo國立暨南國際大學
應用化學系
93
The thesis is divided into two parts. In Part I, analytical magnetapheresis was used to study the interaction of antigen and antibody. In Part II, we studied the dispersion of nanopowder(silica, SiO2)under different surfactants. Part I:Analytical magnetapheresis has become a useful separation technology, in recent years. It is mainly used for macro molecules(MW>106), colloids and particles. This technology was fast, simple, selective and nondestructive. This study used the gradient elution principle. It studied the interactions of Streptavidin-Biotin and IgG-Protein A in analytical magnetapheresis. Experimental parameters were studied under different conditions of the flow rate, injected particles and material channels. The Streptavidin-conjugated magnetic beads and IgG-conjugated magnetic beads can capture silica particles labeled with Biotin and Protein A in the separation channel under magnetic filed. The selectivity is high with controlled experiments. Part II:Nano-scale materials have some special physics properties. Nano-materials play a major role for their physics properties. Aggregation must be avoided for applications of nanopowder. We added surfactant into solution to improve the aggregation condition of silica nanopowder. We have tested several surfactants. Dispersion was improved with adding 0.01% of FL-70 surfactant into solution.
Blackler, Ryan J. "Structural investigations into conformational diversity, polyspecificity, and binding mechanisms of near-germline antibodies". Thesis, 2016. http://hdl.handle.net/1828/7305.
Texto completoGraduate
2019-11-27
Sciammas, Roger. "Function and antigen specificity of the TCR [gamma][delta] cell response to HSV-1 infection /". 1997. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:9832198.
Texto completoHagembe, Juliana Liambaya. "Effect of antigenic site mutations on the binding specificity of an anti-hemagglutinin antibody to H3N2 influenza virus isolates". 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1467107.
Texto completoPyle, Emily Claire. "The kinetics of neutralizing anti-viral antibodies and the production of a T cell-dependent antibody response during vesicular stomatitis virus infection". 2008.
Buscar texto completoLuo, Cheng-Ping [Verfasser]. "Detection of antibody antigen reactions using surface acoustic wave and electrochemical immunosensors / [presented by Cheng-Ping Luo]". 2004. http://d-nb.info/971863121/34.
Texto completoTerrientes, S. Zilka I. "Study of the antigenicity of P. yoelii parasitized erythrocyte ghost antigens and their role in protection". Thesis, 1990. http://hdl.handle.net/10125/9440.
Texto completoGreenwood, John Milton. "The production and characterization of monoclonal antibodies against K88 pili from porcine enterotoxigenic Escherichia coli". 1985. http://hdl.handle.net/2097/27447.
Texto completoLo, Wen-Min y 羅文敏. "The Study of Detection of the Antigen-Antibody Reaction by Pizeoelectric Crystal Biosensor". Thesis, 2001. http://ndltd.ncl.edu.tw/handle/58618301665296958113.
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