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Literatura académica sobre el tema "Anticoagulant rodenticides"

Autor: Grafiati

Publicado: 1 de junio de 2024

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Artículos de revistas sobre el tema "Anticoagulant rodenticides"

De Araújo, Gabriel Rios, Maria Carolina Ricciardi Sbizera, Marcela Lucas De Lima, José Victor Pronievicz Barreto, Michele Monteiro Sudak, Manuela Venturelli Finco, Diego Fagner Michelassi de Souza, Daiene Locoman, Dienifer Kely De Oliveira Ribeiro y Luiz Fernando Coelho Da Cunha Filho. "Avaliação da Palatabilidade e da Resistência de Diferentes Rodenticidas Disponíveis para Uso por Empresas Especializadas, em Aviários no Município de Rolândia, Paraná". UNICIÊNCIAS 21, n.º 1 (24 de agosto de 2017): 2. http://dx.doi.org/10.17921/1415-5141.2017v21n1p2-6.

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A presença de roedores em estabelecimentos gera importantes prejuízos financeiros, além de representar risco à saúde animal e humana, fazendo-se necessário o seu controle. O trabalho teve como objetivo testar produtos rodenticidas disponíveis para o uso profissional quanto à aceitação pelos roedores e a sua resistência às ações ambientais. Foram utilizados três rodenticidas anticoagulantes de dose única; Brodifacum Bloco Parafinado (Syngenta®); Difetialona Bloco Extrusado (Bayer®); e Bromadiolone Bloco Extrusado (De Sangosse®). Os rodenticidas foram acondicionados em porta-iscas distribuídos em quatro aviários de uma granja produtora de aves de corte, no município de Rolândia, PR. Semanalmente, foi anotada a quantidade consumida e a deterioração dos rodenticidas. Os resultados obtidos nas quatro semanas mostram que na situação testada, o Brodifacum representa 68,3% do total de blocos consumidos, o Difetialona 26,7% e o Bromadiolone 5%. Em relação à resistência às ações ambientais, o Bromadiolone teve 19 blocos afetados (23,2%), o Difetialona 30 blocos (36,6%) e o Brodifacum 33 blocos (40,2%), tanto o consumo quanto a resistência entre os blocos não foram significativas estatisticamente. Os dados evidenciam que a escolha do rodenticida tem influência direta na eficiência, devendo ser um quesito valorizado no planejamento das ações de controle de roedores.Palavras-chave: Controle de Roedores. Rodenticida. Aceitação de Rodenticida.AbstractThe presence of rodents in establishments generates significant financial losses, as well as it poses a risk to animals and human’s health, making its control necessary. The study aimed to test rodenticides products available for professional use regarding the rodents’ acceptance and their resistance to environmental actions. Three single dose anticoagulant rodenticides wereused; Brodifacum Block waxed (Syngenta™); Difethialone Block Extruded (Bayer™); and Bromadiolone Block Extruded (De Sangosse™). Rodenticides were placed in bait holders distributed in four aviaries producing broilers in Rolândia city, PR. Thee amount consumed and the deterioration of rodenticides were weekly noted. The results obtained in four weeks show that in the tested situation, Brodifacum represents 68.3% of total consumed blocks, Difethialone 26,7% and Bromadiolone 5%. For resistance to environmental actions, Bromadiolone had 19 blocks affected (23.2%), Difetialona 30 blocks (36.6%) and Brodifacum 33 blocks (40.2%), both consumption and the resistance amongthe blocks were not statistically significant. The data show that the choice of rodenticide directly influences the efficiency and should be a question valued in the planning of rodent control measures.Keywords: Rodent control. Rodenticide. Rodenticides Acceptance.

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Watt, Barbara E., Alex T. Proudfoot, Sally M. Bradberry y J. Allister Vale. "Anticoagulant Rodenticides". Toxicological Reviews 24, n.º 4 (2005): 259–69. http://dx.doi.org/10.2165/00139709-200524040-00005.

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Humphry, N. F. "Anticoagulant rodenticides". Medical Journal of Australia 150, n.º 12 (junio de 1989): 727–28. http://dx.doi.org/10.5694/j.1326-5377.1989.tb136789.x.

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Galstyan, G. M., I. L. Davydkin, A. S. Nikolaeva, N. I. Vekhova, Z. E. Pavlova, I. S. Ponomarenko, E. E. Klebanova y V. G. Savchenko. "Outbreak of mass poisoning with anticoagulant rodenticides". Russian journal of hematology and transfusiology 65, n.º 2 (21 de mayo de 2020): 174–89. http://dx.doi.org/10.35754/0234-5730-2020-65-2-174-189.

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Introduction. Rodenticides are pesticides used in the control of rodents. In Russia, only anticoagulant rodenticides are allowed to be used.Aim: describe a case of mass poisoning with anticoagulant rodenticides.Main findings. An observation is given of poisoning with anticoagulant rodenticides in 80 people due to the consumption of sunflower oil produced from seeds that have been treated with rodenticides. The victims had a pronounced hemorrhagic syndrome: all had ecchymosis, 79 % had macrohematuria, 1 had uterine bleeding, 3 had intra-abdominal hemorrhages, 16 had nosebleeds, 2 had gastrointestinal bleeding, and 2 had intracerebral hemorrhages. The international normalized ratio (INR) was not definable in 56 patients, while the remaining patients had a median INR of 3.9 (fluctuations from 1.29 to 16.2). Activated partial thromboplastin time (APTT) was not definable in 7 patients; the remaining patients had the median APTT of 65 seconds. Three of the victims died of hemorrhagic syndrome. This article analyzes the conducted therapy. In life-threatening hemorrhagic syndrome induced by rodenticide poisoning or warfarin overdose the drugs of choice are prothrombin complex concentrates and recombinant activated clotting factor VII, but not fresh frozen plasma and vicasol. For long-term therapy, vitamin K1 should be used.Conflict of interest: the authors declare no conflict of interest.

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Wilk, Joanna, Magdalena Kubicka, Paweł Dębiec, Przemysław Szydłowski, Magdalena Makarewicz, Mikołaj Porzak y Natalia Szyłkajtis. "Toxic substances in the household - cases of poisoning, therapy, complications". Journal of Education, Health and Sport 44, n.º 1 (18 de agosto de 2023): 104–15. http://dx.doi.org/10.12775/jehs.2023.44.01.007.

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There are many toxic substances used in our houses. Rodent poisons are not the most common group of substances, but cases of poisoning still occur. Long-acting anticoagulant rodenticides, also called superwarfarins, are known for their greater potency, longer half-life and delayed onset of symptoms. Cases of superwarfarin poisoning can pose a diagnostic and clinical challenge due to a wide array of presentations and prolonged severe coagulopathy requiring months of high-dose oral vitamin K therapy. The most common presentation of long-acting anticoagulant rodenticide poisoning is mucocutaneous bleeding, with other common presentations including haematuria, gingival bleeding, epistaxis and gastrointestinal bleeding.We discuss a case of self-poisoning with long-acting anticoagulant rodenticides with a little presentation of sympthoms and disscus about another cases based on the found articles.

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W. Witmer, G. y P. W. Burke. "Influence of vitamin K-rich plant foods on anticoagulant baiting efficacy in wild House Mice, wild Norway Rats, and wild Black Rats". Pacific Conservation Biology 15, n.º 2 (2009): 87. http://dx.doi.org/10.1071/pc090087.

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Rodents introduced to islands have caused the extinction of many species of animals. Anticoagulant rodenticides are relied on to eradicate rodents from these islands, but if the rodents are eating plant materials that contain high amounts of vitamin K (the antidote to anticoagulants) anticoagulant rodenticides may not be effective. In a laboratory trial, individually caged Norway Rats Rattus norvegicus, Black Rats R. rattus and House Mice Mus musculus were fed fresh plant material high in vitamin K (Collards [0.62 mg vitamin K per 100 g] and Brussels Sprouts [0.19 mg vitamin K per 100 g]) for a period of 7 days. When presented later with anticoagulant rodenticides (0.0025% brodifacoum pellets or 0.005% diphacinone pellets) along with the diet of plant material, 94% of the rodents died. We conclude from this study that the presence of green feed rich in vitamin K does not reduce the effectiveness of anticoagulant rodenticides. However, we add a word of caution on one of the findings of our study. While we think the low efficacy (75%) we found in the case of brodifacoum and Black Rats was probably an artifact of small sample size in that treatment group, the result warrants further investigation.

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Chaudhary, Vipin y R. S. Tripathi. "Incidence of Rodent Pests in Cumin (Cuminum cyminum L.) and their Management". Journal of Horticultural Sciences 5, n.º 1 (30 de junio de 2010): 64–67. http://dx.doi.org/10.24154/jhs.v5i1.502.

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Infestation pattern and extent of damage by rodent pests and their management in cumin crop using secondgeneration anticoagulant rodenticides were studied at farmers' fields in Jodhpur district. Monthly trapping throughout the crop season revealed presence of four species, viz., Tatera indica (45.16%), Meriones hurrianae (29.03%), Gerbillus gleadowi and, an arboreal species, Funambulus pennanti (25.81%). Damage to cumin crop was almost on par at the vegetative growth stage and flowering stage, recording 11.00 and 13.50% reduction in plant stand, respectively. Efficacy of two anticoagulant rodenticides viz., difethiaone (0.0025%) and bromadiolone (0.005%) was evaluated by two census methods simultaneously, viz., live burrow count (LBC) and census baiting (CB). Two treatments of either of the anticoagulants, one at vegetative growth and another at flowering stage, resulted in >80% reduction in pest rodent population. Cost:benefit ratio obtained with bromadiolone (0.005%) baiting was 1:10.8. Thus, poison baiting with anticoagulant rodenticides may be practiced twice at (i) vegetative growth and (ii) flowering stage, for effective rodent management in cumin.

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Fisher, Campbell, Howald y Warburton. "Anticoagulant Rodenticides, Islands and Animal Welfare Accountancy". Animals 9, n.º 11 (4 de noviembre de 2019): 919. http://dx.doi.org/10.3390/ani9110919.

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Anticoagulant rodenticides are used to manage rodents in domestic, municipal, agricultural, and conservation settings. In mammals and birds, anticoagulant poisoning causes extensive hemorrhagic disruption, with the primary cause of death being severe internal bleeding occurring over days. The combined severity and duration of these effects represent poor welfare outcomes for poisoned animals. Noting a lack of formal estimates of numbers of rodents and nontarget animals killed by anticoagulant poisoning, the ready availability and worldwide use of anticoagulants suggest that very large numbers of animals are affected globally. Scrutiny of this rodent control method from scientific, public, and regulatory perspectives is being driven largely by mounting evidence of environmental transfer of residual anticoagulants resulting in harmful exposure in wild or domestic animals, but there is also nascent concern for the welfare of targeted rodents. Rodent control incurs a cumulative ledger of animal welfare costs over time as target populations reduced by poisoning eventually recover to an extent requiring another reduction. This ‘rolling toll’ presents a critical contrast to the animal welfare accountancy ledger for eradication scenarios, where rodent populations can be completely removed by methods including anticoagulant use and then kept from coming back (e.g., on islands). Successful eradications remove any future need to control rodents and to incur the associated animal welfare costs.

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Liggett, Alan D., Larry J. Thompson, Ken S. Frazier, Eloise L. Styer y Lowell T. Sangster. "Thymic Hematoma in Juvenile Dogs Associated with Anticoagulant Rodenticide Toxicosis". Journal of Veterinary Diagnostic Investigation 14, n.º 5 (septiembre de 2002): 416–19. http://dx.doi.org/10.1177/104063870201400511.

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Ten cases of thymic hematoma in young dogs (9–24 weeks of age) were reviewed. Anticoagulant rodenticide toxicosis was confirmed in 5 cases. Histologically, hemorrhage caused variable expansion of thymic lobules and interlobular septa. The medulla appeared to be the primary site of hemorrhage. In areas of severe hemorrhage, normal lobular architecture was lost and lymphocytes were admixed in the hemorrhagic exudate. Vasculitis, necrosis of capillaries, and degeneration of the capsule were observed in infarcted areas. In 2 cases, angiofibroplasia indicated a longer interval between onset of thymic hemorrhage and death. The lesions are similar to those in 5 cases of idiopathic thymic hemorrhage. Appropriate samples were not available for anticoagulant rodenticide analysis in 3 of these 5 idiopathic cases. Lesions in confirmed cases of anticoagulant rodenticide toxicosis also are compatible with published descriptions of idiopathic and spontaneous thymic hemorrhage, but are inconsistent with normal thymic involution. Analysis for anticoagulant rodenticides is indicated in cases of thymic hematoma when an obvious cause is not detected at necropsy.

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Vale, Allister y Sally Bradberry. "Warfarin and anticoagulant rodenticides". Medicine 40, n.º 3 (marzo de 2012): 164. http://dx.doi.org/10.1016/j.mpmed.2011.12.002.

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Tesis sobre el tema "Anticoagulant rodenticides"

Daniells, Laura J. "The non-target effects of anticoagulant rodenticides". Thesis, University of Reading, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559253.

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The exposure of primary and secondary non-target species to Second Generation Anticoagulant Rodenticides (SGARs) is widespread and is a cause for concern amongst conservationists. Levels found in wild non-target species range from trace amounts to lethal levels and occur in up to 81% of barn owl carcasses surveyed. The harm caused by low level AR residues carried by many animals in the wild is not well understood, as is the relative toxicity of the different AR compounds to bird species. My experimental work investigated both sub-lethal residues carried by laboratory mice, Mus musculus, and the comparative toxicity of three SGARs (bromadiolone, difenacoum and brodifacoum) to feral pigeon, Columba livia. Laboratory mice were given >LDso doses of three SGAR compounds and were maintained initially with vitamin K supplements. These mice were monitored for 175 days post-dosing, including through pregnancy. No measurable effect of carrying a SGAR-residue was seen on the growth and breeding activity of mice. Using blood-clotting response testing in pigeons, an EDso was determined for SGAR compounds. Bromadiolone was the least toxic compound to pigeons while the toxicity of difenacoum did not differ significantly from brodifacoum. Data from field trials conducted against AR-resistant rat populations was modelled to compare the exposure levels posed by three SGAR compounds used to control the wild rat infestations. The model was in two parts, the uptake and persistence in the rat population, and the secondary exposure posed by the trials. The AR-resistant rat populations were not controlled completely by bromadiolone or difenacoum and this resulted in much higher levels of SGAR entering the food chain through the rats. This in turn led to higher exposure levels in the secondary non-target species. The need for understanding the toxicity level of each compound to the non-target species of concern was highlighted by this work.

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Butler, Sarah Elizabeth. "The sub-lethal effects of second generation anticoagulant rodenticides on birds". Thesis, University of Leicester, 2014. http://hdl.handle.net/2381/29133.

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There are high economic, human health and environmental reasons for using Second Generation Anticoagulant Rodenticides (SGARs) but there is also widespread non-target exposure to a large number of bird of prey species, such as red kites and barn owls. My overall aim was to assess the potential biochemical and physiological impacts of sub-lethal exposure on birds. I determined environmentally realistic doses of two SGARs, brodifacoum (high acute toxicity) and difenacoum (most widely used and detected in wildlife), in a model species, Japanese quail (Coturnix coturnix japonica), and used these doses in subsequent studies. Anticoagulation profiles and liver residues associated with the doses were characterised. Unexpectedly, one dose (0.4 mg kg-1 body weight brodifacoum) induced persistent (> three weeks) residual anticoagulation. Half-life and repeat-exposure studies highlighted the risk to birds from multiple exposures of brodifacoum in particular. Liver half lives in quail were longer than in rats for brodifacoum but shorter for difenacoum. The magnitude and duration of anticoagulation was greatly increased by multiple exposures involving brodifacoum and was the result of a complex interplay (including inhibition of binding and replacement) between residues in the liver. Studies on quail chicks demonstrated that, while chicks were not especially sensitive to SGARs, exposure reduced growth by 5-10%. Overall, my results suggest that the most likely exposure scenario for UK wildlife, that of repeated exposures to difenacoum, is likely to pose relatively little increased risk compared to single exposures. This is not true for brodifacoum, but it is less widely used in the UK. Thus, exposure scenarios likely to be associated with greater risk, such as repeated exposures to brodifacoum or mixed exposure patterns, are probably less common in the UK. This may partially explain why the number of detected rodenticide-induced wildlife mortalities is low.

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Mahjoub, Tarek. "Etudes des propriétés toxicocinétiques et toxicodynamiques des anticoagulants antivitamines K et leurs impacts environnementaux chez les espèces animales non-cibles". Electronic Thesis or Diss., Lyon 1, 2023. https://n2t.net/ark:/47881/m6x34xkf.

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Les rodenticides anticoagulants (AR) constituent un moyen incontournable pour lutter contre les rongeurs nuisibles. L'utilisation écoresponsable des AR tend à limiter l'exposition des espèces non-cibles. Aucune étude sur la prévalence des AR chez les animaux n'a été menée en Tunisie. De ce fait, une première enquête toxicologique a montré que les AR sont incriminés parmi les causes les plus fréquentes d'intoxications aigues aux AR chez le chien. De plus, dans une autre étude, nous avons rapporté que les anticoagulants naturels, comme le férulénol produit par Ferula communis peut causer de lourdes pertes chez les éleveurs locaux. Peu d'études se sont intéressées à la toxicocinétique des AR. Pour évaluer la prévalence d'exposition, le choix de la matrice biologique est primordial et constitue un garant de la robustesse de la méthode utilisée. Le foie est le tissu de stockage des AR et constitue le meilleur prélèvement pour mettre en évidence une exposition chez les animaux. Cependant, ce prélèvement n'est disponible que sur les animaux morts. Par ailleurs, le sang et les fèces peuvent être utilisés sur des animaux vivants. Nous avons étudié la comparaison des trois matrices (foie, sang et fèces), en tenant compte de trois facteurs d'influence : la dose, le sexe et le temps. Nos résultats démontrent que les prélèvements fécaux sont plus utiles que les prélèvements plasmatiques pour le suivi de l'exposition aux AR des animaux domestiques et sauvages. Le tableau clinique lors d'une intoxication aigue aux AR est spectaculaire, cependant, les expositions à faibles doses passent inaperçues mais présentent des effets délétères insidieux sur la santé. L'exposition asymptomatique des animaux domestiques aux AR est peu documentée. Notre étude a montré une prévalence limitée chez les chiens et les chats, contrairement à d'autres travaux où la prévalence chez les prédateurs de la faune sauvage est bien supérieure et dont les analyses ont été réalisés sur les foies d'animaux morts de manière opportuniste, sans tenir compte des animaux sains. Ce travail pourrait générer des idées pour de nouvelles stratégies analytiques et permettrait de mieux aborder les particularités toxicocinétiques et toxicodynamiques chez d'autres espèces non-cibles dans le cadre du développement de nouvelles molécules d'AR plus écoresponsables
Anticoagulant rodenticides (AR) are an essential tool for controlling rodent pests. The environmentally responsible use of AR tends to limit the exposure of non-target species. No study on the prevalence of AR in animals has been conducted in Tunisia. Therefore, a first toxicological survey showed that AR are incriminated as one of the most frequent causes of acute AR poisoning in dogs. Moreover, in another study, we reported that natural anticoagulants, such as ferulenol produced by Ferula communis can cause heavy losses to local farmers. Few studies have focused on the toxicokinetics of AR. To monitor these exposure rates, the validation of the appropriate biological matrix is essential and is a major guarantee of the robustness of the analytical method. The liver is the storage tissue for AR and is the best sample for assessing exposure in animals. However, it is only available from dead animals. Blood and feces can be used from live animals. We studied the comparison of the three matrices (liver, blood, and feces), considering three influencing factors: dose, sex, and time. Our results show that fecal samples are more valuable than plasma samples for monitoring AR exposure in domestic and wild animals. The clinical symptoms of acute AR poisoning are dramatic, but low-dose exposures go unnoticed and present insidious deleterious health effects. Asymptomatic exposure of domestic animals to AR is poorly documented. Our study showed limited prevalence in dogs and cats, in contrast to other work where prevalence in wildlife predators is much higher from analyses performed on the livers of opportunistically dead animals, without considering the healthy ones. This work could generate ideas for new analytical strategies. It would allow better addressing toxicokinetic and toxicodynamic properties in other non-target species as part of the development of new, more eco-friendly AR molecules

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Fisher, P. M. "Residual concentrations and persistence of the anticoagulant rodenticides brodifacoum and diphacinone in fauna". Lincoln University, 2009. http://hdl.handle.net/10182/930.

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Brodifacoum is a highly effective anticoagulant rodenticide that presents a secondary hazard to some non-target wildlife. The high acute toxicity of brodifacoum to mammals and birds, and its prolonged persistence in liver predicates secondary risk to predators and scavengers of poisoned rodents. Hence there is a need to improve ability to monitor and predict hazards of brodifacoum to non-targets, and optimise use patterns accordingly. Use of a less persistent anticoagulant rodenticide, diphacinone, is an alternative approach currently under investigation in New Zealand. This thesis describes a series of laboratory and pen studies that address information gaps relevant to the assessment of non-target hazards in continued use of brodifacoum, and of using diphacinone as an alternative. Non-lethal techniques for determining sublethal brodifacoum exposure in birds was investigated in chickens. Elevation of prothrombin time was a less reliable index than residual concentrations in tissues. Samples requiring less invasive procedures, such as dried blood spots or faeces, have potential to detect recent sublethal brodifacoum exposure and refinement of these indices could be useful in proactive monitoring of avian wildlife. Residual brodifacoum in eggs of sublethally-exposed hens raised further questions regarding wider non-target hazard and adverse effects on development of fertile eggs or chicks. A laboratory trial with rats found a positive correlation between residual brodifacoum concentrations in liver and the amount of brodifacoum ingested as bait. An estimated 14-22% of ingested brodifacoum was excreted in rat faeces in the period between ingestion of a lethal dose and death, indicating another potentially significant environmental pathway for brodifacoum transfer. In considering diphacinone as a less persistent alternative rodenticide to brodifacoum, evaluation of residual concentrations and persistence in pig tissues was required to estimate secondary hazard to human consumers and adequate with-holding periods for hunting feral pigs in areas where diphacinone was applied. A pen trial showed that domestic pigs were more susceptible to diphacinone toxicity, and thus primary poisoning risk, than previously estimated. Hepatic half-life of diphacinone in pigs was approximately 14 days, indicating reduced persistence in comparison to brodifacoum and enabling estimates of with-holding periods for hunting feral pigs from areas where diphacinone baits were applied. To investigate potential hazards of diphacinone use to invertebrates a trial using tree weta, a native New Zealand invertebrate, was undertaken. Weta readily ate diphacinone wax block baits with no mortality or weight loss evident, indicating low susceptibility. Residual whole-body diphacinone concentrations did not increase with the amount of diphacinone bait eaten. A simple, deterministic risk assessment suggested that, as a single secondary exposure, the maximum diphacinone concentration measured in weta would present a low risk to non-target birds. Given international recognition of the high secondary hazard and corresponding restrictions on use of brodifacoum, continued availability of brodifacoum to non-licensed users and sustained field applications for possum and rodent control in New Zealand is an exceptional use pattern. New data in this thesis suggest that baiting strategies that minimise the amount of brodifacoum available in the environment are important and regulatory review of some New Zealand brodifacoum applications should address this. In parallel, development of diphacinone as an alternative to brodifacoum should continue, as new data here confirms lower persistence in mammalian liver than brodifacoum, and also indicates low toxicity to invertebrates. However further investigation of multiple-exposure hazard and potential sublethal effects of diphacinone on non-target mammals and birds is warranted before extensive and sustained field applications of diphacinone are undertaken.

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Loureiro, Maria Adelaide Kress Pinto. "Contribuição para o estudo da fuinha (Martes foina) : aspetos ecológicos, morfológicos e toxicológicos de 40 indivíduos provenientes do Centro de Ecologia, Recuperação e Vigilância de Animais Selvagens (CERVAS)". Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2017. http://hdl.handle.net/10400.5/14236.

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Dissertação de Mestrado Integrado em Medicina Veterinária
Em Portugal a sensibilização para a biodiversidade que possuímos é ainda escassa, sendo da responsabilidade de cada um termos um papel ativo nesta luta. Com esse intuito desenvolveu-se este trabalho, acerca da fuinha (Martes foina), pretendendo aprofundar-se o conhecimento sobre este pequeno habitante das florestas e meios urbanos do nosso país, caracterizando-o em diferentes parâmetros: desde a sua morfologia, características anatómicas, reprodutoras, alimentares e epidemiológicas, até ao seu papel no ecossistema, inclusive na sua relação com a espécie humana. Esta relação tende a ser tendencionalmente desvantajosa para espécies predadoras de animais considerados pragas, devido ao combate destas últimas com compostos tóxicos não seletivos. Uma das consequências da exposição a estes compostos relaciona-se com intoxicações em doses sub-letais, que podem não ser a principal causa de morte, mas predispor a tal ou ao aumento da morbilidade. Foi com o objetivo de perceber um pouco mais sobre este tipo de efeitos na fuinha (espécie predadora de roedores) que este trabalho foi realizado, com especial incidência nos rodenticidas anticoagulantes. A amostra populacional em estudo inclui 21 amostras de fígado de fuinhas provenientes do Centro de Ecologia, Recuperação e Vigilância de Animais Selvagens (CERVAS) e recolhidas entre os anos de 2009 a 2015. Estas amostras foram analisadas pela técnica da Cromatografia de Camada Fina para deteção de rodenticidas anticoagulantes (RAC) e em nenhuma delas estes compostos foram detetados.
ABSTRACT - SUB-LETHAL SECONDARY INTOXICATIONS BY ANTICOAGULANT RODENTICIDES IN FUINHAS: A RETROSPECTIVE STUDY OF 21 CASES BETWEEN 2009 AND 2015. - In Portugal, the awareness of the biodiversity we have is still scarce, and it is our responsibility to play an active role in this struggle. With this intention, this study was developed on the stone marten (Martes foina), aiming to deepen the knowledge about this small inhabitant of the forests and urban environments of our country, characterizing it in different parameters: morphology, anatomical characteristics, reproduction, diet, epidemiology and their role in the ecosystem, including their relationship with the human species. This relationship tends to be disadvantageous for predatory species of animals considered as pests, due to their combating with non-selective toxic compounds. One of the consequences of these compounds is sub-lethal dose intoxications, which may not be the main cause of death, but predispose to such or increased morbidity. The main goal of this study is to understand a little more about this type of effects in the stone marten (predator species of rodents) that this work was carried out, with special incidence on anticoagulant rodenticides. Thin Layer Chromatography tecnhique was used in 21 liver samples from the Centro de Ecologia, Recuperação e Vigilância de Animais Selvagens (CERVAS) between 2009 and 2015, and no second generation anticoagulant rodenticide was detected in any of the samples.
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Jacquot, Marion. "Usage des rodenticides anticoagulants et conséquences en termes d'exposition et d'impact pour les populations de renard roux". Phd thesis, Université de Franche-Comté, 2013. http://tel.archives-ouvertes.fr/tel-00917412.

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Les rodenticides anticoagulants (RA) constituent le principal moyen de lutte contre les rongeurs. L'exposition aux RA du renard roux et l'impact des RA sur les populations de ce prédateur sont étudiés. En France, on distingue un contexte " biocide " (BCD) où les RA sont principalement utilisés près des bâtiments et un contexte " phytopharmaceutique " (PP) où la bromadiolone (un RA) est également utilisée en plein champs contre le campagnol terrestre. La contamination des rongeurs aux RA est mesurée : 5 RA sont détectés en contexte BCD alors que la bromadiolone est la molécule majoritaire en contexte PP ; les espèces de rongeurs non ciblées par les RA étant exposées dans les 2 contextes. L'exposition est maximale chez les espèces ciblées ou celles au mode de vie similaire. L'exposition du renard est évaluée par la mesure des résidus de RA dans des fèces collectées in situ. La bromadiolone est retrouvée dans 97 % des fèces positives et les RA sont plus retrouvés dans les fèces en cas de traitements PP. En contexte PP, le ratio de fèces positives augmente non linéairement avec la surface traitée dans un rayon d'1 km autour des fèces. L'impact des traitements PP sur les populations de renards est évalué (période 2003-2009, département du Doubs). Les indices d'abondance de renard mesurés sur une commune le printemps d'une année n diminuent avec l'augmentation des quantités d'appâts utilisées les années n-1 et n-2. Pendant la période suivie, la mise en place d'une lutte intégrée contre le campagnol terrestre s'est traduite par une diminution des quantités d'AR utilisées et donc par une diminution des impacts sur les populations de renards.

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Fergusson, D. "The effects of 4-hydroxycoumarin anticoagulant rodenticides on birds and the development of techniques for non-destructively monitoring their ecotoxicological effect". Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239503.

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Rached, Antoine. "Exploration des pistes de gestion du risque écotoxicologique associé aux anticoagulants antivitamine K utilisés comme rodonticides". Electronic Thesis or Diss., Lyon, 2022. http://www.theses.fr/2022LYSE1077.

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Les anticoagulants antivitamines K (AVKs) constituent actuellement le moyen de lutte chimique le plus efficace contre les infestations de rongeurs dans les zones rurales et urbaines. Pour assurer un effet létal, les AVKs de première génération doivent être ingérés en plusieurs doses pendant plusieurs jours consécutifs. Cependant, cette consommation chronique était à l'origine de l'apparition d'une résistance à ces molécules chez certaines populations de rongeurs commensaux nuisibles, les rendant moins efficaces. Une deuxième génération de rodonticides anticoagulants a été développée pour surmonter cette résistance. Cette génération est plus puissante (une concentration plus faible d’AVK pour induire la mortalité) et a une durée d'action plus longue (persistance plus longue dans l'organe cible). L'intoxication des animaux non-cibles est le principal inconvénient de la deuxième génération. En effet, l'accès direct à l'appât toxique et la consommation de proies empoisonnées peuvent entraîner des expositions de la faune non-cible. Afin de réduire ce risque écotoxicologique des anticoagulants rodonticides, des solutions ont été envisagées notamment la réduction de la concentration des appâts et l’utilisation des isomères d’AVK (la stéréochimie) qui ont déjà démontré un temps de rétention hépatique court avec une efficacité pareille aux molécules AVKs raticides déjà sur le marché. L’objectif principal de ce travail de thèse est d’explorer ces pistes de gestion de ce risque. Nous nous sommes intéressés dans un premier temps à étudier la pertinence des avantages de la stéréochimie dans le contrôle des différentes espèces de rongeurs nuisibles, notamment les rats, les souris et les campagnols terrestres et chez les deux sexes mâles et femelles. Dans un second temps, nous avons comparé l’évolution des résidus d’AVK chez des rats mâles après administration soit d’une dose faible d’AVK, soit d’une dose forte dans un but d’explorer l’effet de la réduction de la concentration des appâts en AVK sur les résidus restants dans le foie. Ces pistes de gestion ont bien montré leur capacité à réduire les résidus des AVKs, responsables de l’intoxication des espèces non-cibles par la consommation de proies empoisonnées
Vitamin K antagonists (VKA) are currently the most effective chemical control of rodent infestations in rural and urban areas. To ensure a lethal effect, first-generation VKA must be ingested in multiple doses over several consecutive days. However, this chronic consumption was responsible for the development of resistance to these molecules in certain populations of commensal rodents, making them less effective. A second generation of anticoagulant rodenticides was developed to overcome this resistance. This generation is more potent (lower concentration of VKA to induce mortality) and has a longer duration of action (longer persistence in the target organ). The intoxication of non-target animals is the main drawback of the second generation. Indeed, direct access to the toxic bait and the consumption of poisoned prey can lead to exposure of non-target fauna. In order to reduce this ecotoxicological risk of rodenticide anticoagulants, some solutions have been considered such as the reduction of bait concentration and the use of VKA isomers (stereochemistry) which have already demonstrated short tissue retention time with an efficiency similar to VKA rodenticide molecules currently available on the market. The main objective of this thesis work is to explore these possibilities for managing this risk. First, we studied the relevance of the benefits of stereochemistry in the control of different species of rodent pests including rats, mice and water voles and in both male and female species. In a second phase, we compared the evolution of VKA residues in male rats after administration of either a low or a high dose of VKA in order to explore the effect of reducing the concentration of VKA baits on the residues remaining in the liver. These management approaches have been shown to reduce the residues of VKA, which are responsible for the intoxication of non-target species through the consumption of poisoned prey

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Jorge, Ana Patrícia Mestre de Oliveira. "Clínica e cirurgia em animais de companhia: intoxicação por rodenticidas anticoagulantes". Master's thesis, Universidade de Évora, 2015. http://hdl.handle.net/10174/16227.

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O presente relatório de estágio diz respeito às atividades desenvolvidas durante o período de estágio curricular do mestrado integrado em Medicina Veterinária ministrado pela Universidade de Évora. O estágio curricular decorreu no Hospital Veterinário da Arrábida (HVA) durante 6 meses, compreendidos entre 15 de Setembro de 2014 a 15 de Março de 2015, sob orientação da Dr.ª. Margarida Fragoso Costa e coorientação da Dr.ª. Ângela Martins. Este relatório é constituído por um resumo da casuística assistida, por uma monografia subordinada ao tema “Intoxicação por rodenticidas anticoagulantes” e um estudo comparativo de casos clínicos relacionados com o tema da monografia. A intoxicação por rodenticidas anticoagulantes é um dos mais frequentes tipos de intoxicação na clínica de animais de companhia, sendo importante o conhecimento por parte do médico veterinário dos diferentes tipos de rodenticidas existentes, bem como abordagem a esta patologia e ao paciente intoxicado no geral; Abstract: - Small animal medicine and surgery This report aims to describe the activities developed during my curricular internship of my masters in veterinary medicine degree at the University of Évora. The internship took place at the Hospital Veterinário da Arrábida (HVA) with the duration of six months, from 15 September 2014 to 15 March 2015, under the supervision of Dr. Margarida Fragoso Costa and co-supervision of Dr. Ângela Martins. This report consists of a summary of assisted cases, a bibliographic review entitled "Anticoagulant rodenticides poisoning” and a comparative study of clinical cases related to this subject. Poisoning by anticoagulant rodenticides is one of the most frequent types of poisoning in the small animal clinic. It is important for the veterinary to have knowledge of the different types of rodenticides and how to approach this issue, as well as the overall intoxicated patient.

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Chia, Tio-Huat. "Growth, distribution and susceptibility of major rat species to anticoagulant rodenticides and the inheritance of resistance to warfarin in Rattus tiomanicus in oil palm plantations in peninsular Malaysia". Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342461.

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Libros sobre el tema "Anticoagulant rodenticides"

van den Brink, Nico W., John E. Elliott, Richard F. Shore y Barnett A. Rattner, eds. Anticoagulant Rodenticides and Wildlife. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-64377-9.

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Anticoagulant Rodenticides. World Health Organization, 1995.

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Elliott, John E., Nico W. van den Brink, Richard F. Shore y Barnett A. Rattner. Anticoagulant Rodenticides and Wildlife. Springer, 2018.

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Elliott, John E., Nico W. van den Brink, Richard F. Shore y Barnett A. Rattner. Anticoagulant Rodenticides and Wildlife. Springer, 2017.

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Koivisto, Sanna, Senja Laakso y Kati Suomalainen. Literature Review on Residues of Anticoagulant Rodenticides in Non-Target Animals. Nordic Council of Ministers, 2010. http://dx.doi.org/10.6027/tn2010-541.

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Difenacoum Health and Safety Guide (Health & Safety Guide: 95). World Health Organization, 1995.

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Bromadiolone Health and Safety Guide (Health & Safety Guide: 94). World Health Organization, 1995.

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Assessing Anticoagulant Resistance in Rats and Coagulation Effects in Birds Using Small-Volume Blood Samples. Not Avail, 2005.

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Capítulos de libros sobre el tema "Anticoagulant rodenticides"

van den Brink, Nico W., John E. Elliott, Richard F. Shore y Barnett A. Rattner. "Anticoagulant Rodenticides and Wildlife: Introduction". En Emerging Topics in Ecotoxicology, 1–9. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64377-9_1.

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van den Brink, Nico W., John E. Elliott, Richard F. Shore y Barnett A. Rattner. "Anticoagulant Rodenticides and Wildlife: Concluding Remarks". En Emerging Topics in Ecotoxicology, 379–86. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64377-9_14.

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Berny, Philippe, Alexandra Esther, Jens Jacob y Colin Prescott. "Development of Resistance to Anticoagulant Rodenticides in Rodents". En Emerging Topics in Ecotoxicology, 259–86. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64377-9_10.

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López-Perea, Jhon J. y Rafael Mateo. "Secondary Exposure to Anticoagulant Rodenticides and Effects on Predators". En Emerging Topics in Ecotoxicology, 159–93. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64377-9_7.

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Hindmarch, Sofi y John E. Elliott. "Ecological Factors Driving Uptake of Anticoagulant Rodenticides in Predators". En Emerging Topics in Ecotoxicology, 229–58. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64377-9_9.

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Jacob, Jens y Alan Buckle. "Use of Anticoagulant Rodenticides in Different Applications Around the World". En Emerging Topics in Ecotoxicology, 11–43. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64377-9_2.

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Horak, Katherine E., Penny M. Fisher y Brian Hopkins. "Pharmacokinetics of Anticoagulant Rodenticides in Target and Non-target Organisms". En Emerging Topics in Ecotoxicology, 87–108. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64377-9_4.

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Witmer, Gary W. "Perspectives on Existing and Potential New Alternatives to Anticoagulant Rodenticides and the Implications for Integrated Pest Management". En Emerging Topics in Ecotoxicology, 357–78. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64377-9_13.

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Veenstra, G. E., D. E. Owen y K. R. Huckle. "Metabolic and Toxicological Studies on the Anticoagulant Rodenticide, Flocoumafen". En Archives of Toxicology, 160–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-74936-0_32.

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Middleberg, Robert A. y Joseph Homan. "Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS". En Methods in Molecular Biology, 139–48. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-934-1_12.

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Actas de conferencias sobre el tema "Anticoagulant rodenticides"

Rubinstein, I., D. Feinstein, R. Van Breemen, J. Hafner y D. Nosal. "Safe Treatment Duration with Oral Vitamin K1in Patients Poisoned with Inhaled Synthetic Cannabinoids Contaminated with Brodifacoum, a Long-Acting Anticoagulant Rodenticide". En American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3112.

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