Tesis sobre el tema "Airway epithelium"
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Shebani, Eyman. "Ultrastructural Studies of the Airway Epithelium in Airway Diseases". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6632.
Texto completoStevens, Paul. "Intrinsic differences of the airway epithelium in childhood allergic asthma". University of Western Australia. School of Paediatrics and Child Health, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0022.
Texto completoScull, Margaret Adele Pickles Raymond J. "Myxovirus interaction with the human airway epithelium". Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2848.
Texto completoTitle from electronic title page (viewed Jun. 4, 2010). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine.
Wang, Jiahua. "The role of airway epithelium in airway inflammation and effect of corticosteroids". Thesis, Queen Mary, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300175.
Texto completoRowley, Jessica. "The interaction of Aspergillus fumigatus with the respiratory epithelium". Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-interaction-of-aspergillus-fumigatus-with-the-respiratory-epithelium(0fc10449-977d-4f14-a169-172e8204fee4).html.
Texto completoFox, Emma. "Systemic delivery of DNA to the airway epithelium". Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409742.
Texto completoLeahy, Rachel A. "Signal Transduction and Cellular Differentiation in Airway Epithelium". Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1352673026.
Texto completoFORTNER, CHRISTOPHER NEIL. "EPITHELIUM-DEPENDENT RELAXATION OF AIRWAY SMOOTH MUSCLE IS LINKED TO EPITHELIAL CHLORIDE CURRENTS". University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin983467525.
Texto completoWilliams, M. T. S. "Impact of different CFTR Mutations on Airway Epithelium Function". Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527902.
Texto completoJing, Yi. "Epithelial mechanisms in airway responses induced by hyperosmolarity". Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5054.
Texto completoTitle from document title page. Document formatted into pages; contains xiv, 155 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
Nilsson, Harriet. "Studies of Tight Junctions and Airway Surface Liquid in Airway Epithelium with Relevance to Cystic Fibrosis". Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-99411.
Texto completoArmit, Christopher James. "p53 and responses to DNA damage in small airway epithelium". Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/27777.
Texto completoStefanowicz, Dorota. "Profiling the epigenetic landscape of the airway epithelium in asthma". Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/47071.
Texto completoMcGrogan, Ita. "Release and actions of prostaglandin E¦2 from canine airway epithelium". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0003/NQ42751.pdf.
Texto completoAmineh, Abbadi. "Hyaluronan Rafts on Airway Epithelial Cells". Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1407316041.
Texto completoKao, Cheng-Yuan. "Molecular characterization of human airway epithelium innate immunity by IL-17 regulation /". For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.
Texto completoXenariou, Stefania. "Magnetofection and sonoporation to enhance non-viral gene transfer to airway epithelium". Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433595.
Texto completoJohnston, Richard A. "Characterization of the airway epithelial bioelectric mechanisms associated with the effects of epithelium-derived relaxing factor in guinea-pig isolated trachea". Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1776.
Texto completoTitle from document title page. Document formatted into pages; contains ix, 135 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 127-135).
Fischer, Anthony John. "Augmenting antiviral host defense in the respiratory epithelium". Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/500.
Texto completoAng, Sherlynn. "Characterising and assessing the baseline functionality of the airway epithelium in preterm infants". Thesis, Ang, Sherlynn (2017) Characterising and assessing the baseline functionality of the airway epithelium in preterm infants. Honours thesis, Murdoch University, 2017. https://researchrepository.murdoch.edu.au/id/eprint/39878/.
Texto completoRelova, Anne-Jacqueline. "Mechanisms for and Effects of Airway Epithelial Damage in Asthma". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5312-0/.
Texto completoShum, Bennett Oh Vic St Vincent's Clinical School UNSW. "Regulation of allergic asthma by fatty acid-binding proteins". Awarded by:University of New South Wales. St. Vincent's Clinical School, 2007. http://handle.unsw.edu.au/1959.4/27002.
Texto completoMillar, Büchner Pamela [Verfasser] y Marcus A. [Akademischer Betreuer] Mall. "Role of the epithelial Cl- channel SLC26A9 in the murine airway epithelium / Pamela Millar Büchner ; Betreuer: Marcus A. Mall". Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1237270790/34.
Texto completoFarnell, Edward John. "Cloning, disruption and characterisation of Aspergillus fumigatus allergen proteases and their effect on airway epithelial cells". Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/cloning-disruption-and-characterisation-of-aspergillus-fumigatus-allergen-proteases-and-their-effect-on-airway-epithelial-cells(cee1b5be-76cd-477c-bdb8-bdaa945d4e02).html.
Texto completoLeir, Shih-Hsing. "ICAM-1 and CD44 expression in human bronchial epithelium and the role of CD44 isoforms in cell adhesion, migration, and repair". Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323933.
Texto completoNakatsuka, Yoshinari. "Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia". Kyoto University, 2018. http://hdl.handle.net/2433/235979.
Texto completoNordenhäll, Charlotta. "Airway effects of diesel exhaust in healthy and asthmatic subjects". Doctoral thesis, Umeå universitet, Lungmedicin, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96901.
Texto completoDiss. (sammanfattning) Umeå : Umeå universitet, 2002, härtill 4 uppsatser.
digitalisering@umu
Wilson, Kirsty. "Modelling the airway epithelium in vitro as a tool for understanding pulmonary innate defence mechanisms". Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/13496/.
Texto completoYahaya, Badrul H. "Analysis of time-dependent transcriptomic and phenotypic changes associated with repair and regeneration in the airway epithelium". Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4800.
Texto completoMurphy, Desmond Michael. "The potential role of the airway epithelium and novel therapeutic strategies in post-transplant obliterative bronchiolitis". Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485564.
Texto completoTcacencu, Ion. "Regenerative medicine of the airway cartilage : a morphological and immunohistochemical study with focus on cricoid cartilage defects treated with BMP 2 /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-345-0/.
Texto completoAyers, M. "The effect of tobacco smoke on renewal mechanisms in airway epithelium and changes induced by N-acetylcysteine". Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/46947.
Texto completoTully, Jane Elizabeth. "Classical and alternative nuclear factor-kappaB in epithelium: impacts in allergic airway disease and avenues for redox regulation". ScholarWorks @ UVM, 2014. http://scholarworks.uvm.edu/graddis/500.
Texto completoMoisey, Elizabeth Jane. "The innate immune response of large and small airway epithelium to respiratory pathogens in chronic obstructive pulmonary disease". Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3443.
Texto completoAlonso, Pedro A. "Regional differences in the response of the hamster airway epithelium to elastase: In vivo and In vitro studies". Thesis, Boston University, 1994. https://hdl.handle.net/2144/37997.
Texto completoPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
The hamster model of experimental chronic bronchitis comprises a persistent increase in the proportion of bronchial granulated secretory cells after a single intratracheal instillation of elastase. This granulated secretory cell increase, which does not occur in the trachea, has been termed secretory cell metaplasia (SCM). Susceptibility of the bronchial epithelium may be due to a large population of elastase-responsive cells specific to this region. Three dimensional reconstruction of the major form of bronchial secretory cells revealed very little or no rough endoplasmic reticulum (RER), thus demonstrating significant regional heterogeneity since all epithelial secretory cells in the trachea have abundant RER. Animals with bronchial SCM were stimulated with pilocarpine to determine whether the cells subsequent to discharge would re-accumulate granules, thus indicating a permanent phenotypic change. However, bronchial secretory cells failed to discharge at doses equal to and greater than those claimed to be effective in rats. Elastase instilled intratracheally was immuno-localized in the hamster airways to assess the possibility of regional differences in cellular uptake of the enzyme. Elastase was not seen intracellularly in trachea or bronchus suggesting that initiation of bronchial SCM results from a cell surface effect, possibly because of elastase-specific sites on bronchial but not tracheal cells. Tracheal resistance was tested by challenging the epithelial cells in vivo and in vitro with very high doses of elastase. Light and electron microscopy revealed no evidence of a stimulation of the mucus synthetic apparatus, suggesting that tracheal epithelial cells are inherently resistant to proteolytic up-regulation.
2031-01-01
Shao, Xingguo. "Identification of a Tans-differentiation factor, Rad, a small Ras-like GTP-binding protein, in the regulation of epithelial cell differentiation in human airway epithelium /". For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.
Texto completoAcciani, Thomas H. "EGF Receptor Signaling and Diesel Exhaust Particle Exposure in Asthma Pathogenesis". University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1428068959.
Texto completoCampbell, Sara J. "Mechanisms of Moraxella catarrhalis Induced Immune Signaling in the Pulmonary Epithelium". University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1268141520.
Texto completoBhandari, Anita [Verfasser]. "Impact of cigarette smoke exposure on the airway epithelium of Drosophila melanogaster to model COPD-like phenotypes / Anita Bhandari". Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1181096731/34.
Texto completoPerng, Diahn-Warng. "The proinflammatory actions of mast cell tryptase and agonists of protease activated receptor 2 on the human airway epithelium". Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327262.
Texto completoMachala, Anna. "Rhinovirus infection of the human airway epithelium : in vitro characterization of viral replication, inflammatory response, and immunemodulating effects of echinacea". Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31854.
Texto completoScience, Faculty of
Zoology, Department of
Graduate
Larson, Shawnessy Dawn. "The distribution of the neural components within the airway epithelium in healthy animals and animals exposed to allergens and/or ozone /". For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.
Texto completoCARBONE, ANNALUCIA. "Isolation of human amniotic stem cells from term placenta and their in vitro differentation in airway epithelium to correct CF phenotype". Doctoral thesis, Università degli Studi di Cagliari, 2012. http://hdl.handle.net/11584/266062.
Texto completoServetnyk, Zhanna. "Functional Aspects of Epithelia in Cystic Fibrosis and Asthma". Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8905.
Texto completoThe cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP activated chloride channel in the apical membrane of epithelial cells, is defective in patients with cystic fibrosis (CF). Research efforts are focused on chloride channel function in order to find a cure for the disease.
Genistein increased chloride transport in normal and delF508-CFTR cultured airway epithelial cells without cAMP stimulation. Prior pretreatment with phenylbutyrate did not affect the rate of the genistein-stimulated chloride efflux in these cells.
S-nitrosoglutathione is an endogenous bronchodilator, present in decreased amounts in the lungs of CF patients. We studied the effect of GSNO on chloride (Cl-) transport in primary nasal epithelial cells from CF patients homozygous for the delF508-CFTR mutation, as well as in two CF cell lines, using a fluorescent Cl- indicator and X-ray microanalysis. GSNO increased chloride efflux in the CF cell lines and in primary nasal epithelial cells from CF patients. This effect was partly mediated by CFTR. If the cells were exposed to GSNO in the presence of L-cysteine, Cl- transport was enhanced after 5 min, but not after 4 h. GSNO may be a candidate for pharmacological treatment of CF patients.
Chloride transport properties of cultured NCL-SG3 sweat gland cells were investigated. The CFTR protein was neither functional nor expressed in these cells. Ca2+-activated chloride conductance was confirmed and the putative Ca2+-activated chloride channel (CaCC) was further characterized in term of its pharmacological sensitivity.
Corticosteroids, the primary treatment for asthma, cause necrosis/apoptosis of airway epithelial cells. It was investigated whether a newer generation of drugs used in asthma, leukotriene receptor antagonists, had similar effects. Both montelukast and dexamethasone, but not beclomethasone or budesonide induced apoptosis/necrosis in superficial airway epithelial cells. Montelukast and corticosteroids also caused decreased expression of intercellular adhesion molecule -1 (ICAM-1) in epithelial but not endothelial cells.
Pandey, Sumali. "Lung mucosal response to repeated inhalational insults with immunomodulatory agents in a murine model of fungal asthma| Airway epithelium takes the center stage". Thesis, North Dakota State University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3603972.
Texto completoAsthma is a debilitating disease of the lungs affecting 235 million people worldwide. Fungus-associated asthma leads to a particularly severe type of disease, and exposure to environmental fungi and their products is unavoidable due to the ubiquitous nature of fungal species. Besides being allergenic, fungi are opportunistic pathogens, and anti-fungal and/or allergic pathways may be modified through repeated inhalation of immunomodulatory agents, affecting the outcome of fungus-induced asthma.
Our aim in this project was to investigate the extent to which repeated inhalation of immunomodulatory agents influence the lung mucosal responses in a naïve murine host or in one that had been sensitized to fungal proteins (allergic). The immunomodulatory substances chosen hold relevance to human inhalational exposure, and included live or irradiation-killed Aspergillus fumigatus (a fungi) spores, deoxyxnivalenol (a mycotoxin), and fluticasone propionate (an inhalationally administered corticosteroid, commonly prescribed for allergic asthma). In a naïve host, inhalation of live A. fumigatus spores showed pathological features of fungal asthma. However, in an allergen-sensitized lung, both dead and live A. fumigatus spores established fungal airway disease, albeit to different extents. Next, we tested the effect of deoxynivalenol in an allergic host and found that its repeated inhalation did not affect pulmonary disease pathology, but did lead to a dose- and time- dependent increase in mucosal and systemic total IgA. Finally, we tested the effect of fluticasone propionate, and found that it did not influence the development of fungal airway disease, but did induce dynamic changes in lung physiology and antibody titers.
Besides mimicking human inhalational exposures, inhalation ensures direct interaction of the inhaled substances with airway epithelium, which plays an important role in defense against inhaled substances and in asthma pathophysiology. By analyzing various mechanisms involved in murine lung-mucosal response to the inhaled substances, a critical involvement of airway epithelium as an orchestrator of immune responses is highlighted, and this would inform mechanism-based future studies. In conclusion, this project is likely to aid in establishing evidence based standards for fungus-related exposures and in making informed therapeutic decisions for fungus-associated diseases.
Pandey, Sumali. "Lung Mucosal Response to Repeated Inhalational Insults with Immunomodulatory Agents in a Murine Model of Fungal Asthma: Airway Epithelium Takes the Center Stage". Diss., North Dakota State University, 2013. https://hdl.handle.net/10365/26759.
Texto completoNorth Dakota State University. Microbiological Sciences Department
Concordia College (Moorhead, MN). Biology Department
Ruiz, Garcia Sandra. "Appréhender l'hétérogénéité cellulaire et la dynamique de différenciation des épithéliums des voies aériennes au moyen de signatures transcriptionnelles sur cellule unique". Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4204/document.
Texto completoHuman airways are lined by a pseudostratified epithelium mainly composed of basal and columnar cells, among these cells we can find multiciliated, secretory cells and goblet cells. All these cells work together in the mucociliary clearance of the airways. This epithelium regenerates slowly under homeostatic conditions but is able to recover quickly after aggressions through proliferation, migration, polarization and differentiation processes. However, in patients with chronic pulmonary diseases such as chronic obstructive pulmonary disease, asthma or cystic fibrosis, epithelial repair is defective, tissue remodeling occurs, leading to loss of multiciliated cells and goblet cell hyperplasia, impairing correct mucociliary clearance. The sequence of cellular events leading to a functional or remodelled tissue are still poorly described. Hence, we aim at identifying the successive cell types appearing during tissue regeneration and the molecular events that are responsible for healthy or pathological regeneration. We have analysed airway epithelial cell composition at several stages of differentiation using an in vitro 3D culture model which reproduces in vivo epithelial cell composition. Applying single cell transcriptomics and computational methods, we have identified cell lineage hierarchies and thus constructed a comprehensive cell trajectory roadmap in human airways. We have confirmed the cell lineages that have been previously described and have discovered a novel trajectory linking goblet cells to multiciliated cells. We have also discovered novel cell populations and molecular interactors involved in the process of healthy human airway epithelium regeneration. Using these approaches, we have finally shed light on cell-type specific responses involved in pathological goblet cell hyperplasia. Our data, by bringing significant contributions to the understanding of differentiation’s dynamics in the context of healthy and pathological human airway epithelium, may lead to the identification of novel therapeutic targets
Österlund, Camilla. "Activation of lung epithelial cells by group 2 mite allergens". Doctoral thesis, Umeå universitet, Lungmedicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51619.
Texto completoSteiert, Sabrina [Verfasser], Carsten [Akademischer Betreuer] Schmidt-Weber y Klaus [Akademischer Betreuer] Schümann. "Evaluation of Anti-inflammatory Potential of Tesalin on Airway Epithelium and Innate Immune Effector Cells / Sabrina Steiert. Betreuer: Carsten Schmidt-Weber. Gutachter: Carsten Schmidt-Weber ; Klaus Schümann". München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1091562113/34.
Texto completoRuiz, Garcia Sandra. "Appréhender l'hétérogénéité cellulaire et la dynamique de différenciation des épithéliums des voies aériennes au moyen de signatures transcriptionnelles sur cellule unique". Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4204.
Texto completoHuman airways are lined by a pseudostratified epithelium mainly composed of basal and columnar cells, among these cells we can find multiciliated, secretory cells and goblet cells. All these cells work together in the mucociliary clearance of the airways. This epithelium regenerates slowly under homeostatic conditions but is able to recover quickly after aggressions through proliferation, migration, polarization and differentiation processes. However, in patients with chronic pulmonary diseases such as chronic obstructive pulmonary disease, asthma or cystic fibrosis, epithelial repair is defective, tissue remodeling occurs, leading to loss of multiciliated cells and goblet cell hyperplasia, impairing correct mucociliary clearance. The sequence of cellular events leading to a functional or remodelled tissue are still poorly described. Hence, we aim at identifying the successive cell types appearing during tissue regeneration and the molecular events that are responsible for healthy or pathological regeneration. We have analysed airway epithelial cell composition at several stages of differentiation using an in vitro 3D culture model which reproduces in vivo epithelial cell composition. Applying single cell transcriptomics and computational methods, we have identified cell lineage hierarchies and thus constructed a comprehensive cell trajectory roadmap in human airways. We have confirmed the cell lineages that have been previously described and have discovered a novel trajectory linking goblet cells to multiciliated cells. We have also discovered novel cell populations and molecular interactors involved in the process of healthy human airway epithelium regeneration. Using these approaches, we have finally shed light on cell-type specific responses involved in pathological goblet cell hyperplasia. Our data, by bringing significant contributions to the understanding of differentiation’s dynamics in the context of healthy and pathological human airway epithelium, may lead to the identification of novel therapeutic targets