Tesis sobre el tema "AHAS"
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Ernst, Stephanie. "Ahas, König von Juda : ein Beitrag zur Literatur und Geschichte des Alten Israel /". St. Ottilien : EOS Verl, 2006. http://catalogue.bnf.fr/ark:/12148/cb41111077t.
Texto completoVargas, Leandro. "Resistência de Euphorbia heterophylla L. aos herbicidas inibidores da enzima acetolactato sintase (ALS/AHAS)". Universidade Federal de Viçosa, 2000. http://www.locus.ufv.br/handle/123456789/10149.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico
A ocorrência de plantas daninhas resistentes a herbicidas é um fato novo no Brasil. A caracterização da resistência é importante para embasar previsões e eleger métodos de manejo e controle. Desse modo, foram realizados na Universidade Federal de Viçosa, de março de 1997 a julho de 1999, quatro experimentos, objetivando de identificar biótipos resistentes e caracterizar a resistência. O primeiro experimento objetivou identificar e estudar os mecanismos envolvidos na resistência, cujos resultados indicaram resistência cruzada aos herbicidas inibidores da enzima ALS. Estudos com ALS, extraída de plantas resistentes de leiteiro, indicaram I50 superior a 3.000 μM para o imazapyr e 2.000 μM para o imazethapyr, contrastando com valores de I50 de 2 μM para aquele e 0,7 μM para este em plantas sensíveis. No segundo experimento, investigou-se a resposta dos biótipos resistentes a herbicidas com diferentes mecanismos de ação. Constatou-se que os herbicidas inibidores da ALS controlaram com eficiência o biótipo sensível, à exceção do flumetsulan; já sobre o biótipo resistente, somente o herbicida imazapyr, na maior dose, apresentou controle. Os herbicidas com mecanismos de ação distintos daqueles dos inibidores da ALS apresentaram-se altamente eficientes no controle dos biótipos resistentes e sensíveis quando aplicados de forma isolada ou em mistura. O terceiro experimento objetivou descrever uma técnica de cruzamento controlado em Euphorbia heterophylla L. Os resultados evidenciaram que as polinizações e emasculações realizadas no estádio 1 produzem grande número de ciátios com uma ou duas sementes e raramente com três. As realizadas no estádio 2, ou acima deste, garantiram o sucesso dos cruzamentos com boa produção de sementes. No quarto experimento, estudaram-se a herança, o número de genes que conferem a resistência e o grau de resistência dos biótipos homozigotos e heterozigotos resistentes. As plantas F1 mostraram-se totalmente resistentes ao herbicida, indicando que a resistência é nuclear e dominante. As plantas F2 apresentaram alta probabilidade para segregação 3:1, evidenciando que a resistência é codificada por um gene dominante. Pela aplicação de doses crescentes de imazethapyr sobre as plantas F1, calculou-se que os biótipos homozigotos resistentes e os heterozigotos apresentaram o mesmo grau de resistência para doses de até 1.600 g ha-1 desse herbicida. Os resultados permitiram concluir que a insensibilidade da enzima ALS aos herbicidas que a inibem é o principal mecanismo responsável pela resistência das plantas de Euphorbia heterophylla L. a tais produtos. Os biótipos resistentes são controlados com eficiência com herbicidas com mecanismos de ação distintos daqueles dos inibidores da ALS. A resistência é codificada por um gene dominante nuclear com dominância completa.
The occurrence of herbicide-resistant weeds is a new fact in Brazil. The characterization of the resistance is important to provide a base for previsions and select methods of management and control. Therefore, four experiments were carried out at the Universidade Federal de Viçosa, from March,1997, to July, 1999, to identify resistant biotypes and to study the mechanisms involved in resistance. The first experiment, aimed to identify and study the mechanisms involved in the resistance, had the results indicating cross resistance to ALS inhibitory herbicides. Studies with ALS, extracted from resistant plants, showed l50 superior to 3000 μM for imazapyr and 2000 μM for imazethapyr, which contrasted with l50 values of 2 μM for the former and 0.7 μM for the latter in susceptible plants. The second experiment analyzed the response of the resistant biotypes to herbicides with different modes of action. It was verified that the ALS inhibitory herbicides had efficient control over the susceptible biotypes, apart from flumetsulan; as for the resistant biotype, only the herbicide imazapyr at its highest dose, showed control. The herbicides with modes of action distinct from those ALS inhibitors were shown highly efficient on controlling susceptible and resistant biotypes when applied separately or in mixture. The third experiment aimed to describe a technique of controlled crossings in Euphorbia heterophylla L. The results showed evidence that pollination and emasculation performed at stage 1 produce a great number of ciatios with one or two seeds and rarely with three. Those performed at stage 2, or above this stage, assured the success of the crossings with a good production of seeds. In the fourth experiment, the inheritance, the number of genes that confer resistance and the degree of resistance in resistant homozygote and heterozygote biotypes, were studied. The F1 plants were shown totally resistant to the herbicide, indicating that the resistance is nuclear and dominant. The F2 plants presented a high probability for 3:1 segregation, making evident that the resistance is codified by a dominant gene. It was calculated that the biotypes resistant homozygote and heterozygote showed the -1 same degree of resistance for doses up to 1600 g ha , by means of the application of increasing doses of imazethapyr on F1 plants. The results obtained permit the conclusion that the insensitivity of the ALS enzyme to the herbicides is the primary mechanism responsible for the resistance of Euphorbia heterophylla L. to such products. The resistant biotypes are efficiently controlled by herbicides with mechanism of action distinct from those of the ALS inhibitors. The resistance is codified by a nuclear dominant gene with complete dominance.
Friesen, Lincoln Jacob Shane. "Identification of the mechanisms of wild radish herbicide resistance to PSII inhibitors, auxinics, and AHAS inhibitors". University of Western Australia. School of Plant Biology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0106.
Texto completoSilva, Viviane Aparecida. "Estudo, por modelagem molecular, da inibição da enzima acetohidroxiácido sintase utilizando diferentes derivados pirimidinilsalicilatos". Universidade Federal de Uberlândia, 2017. http://dx.doi.org/10.14393/ufu.di.2018.94.
Texto completoHerbicides inhibitors of the enzyme acetohydroxyacid synthase (AHAS) present high efficiency in the inhibitory activity with low doses of application and low toxicity for man and the environment. However, several weeds are getting resistence to some classes of herbicides, mainly in the case of AHAS group. Therefore, a proper computational planning of new bioactive compounds is crucial area to model new herbicides. In this study, the enzyme-herbicide interactions were analyzed from the analogous derivated of the pyrimidinylsalicylates group (PSA) which are AHAS inhibitors using quantum- mechanical and molecular docking calculations. The molecular properties obtained after running computer calculation shown that the volume and molecular area can make influence on the inhibition capacity of the ligand, neverthenless, the substituent group has more influence on this parameter. Electronical properties from the HOMO orbitals can certanly make influence on the biological activity due its electron donor capability. The binding free energies of the ligand on the enzyme after docking calculation ranged from - 1.88 to 4.50 kcal mol- 1 , whereas, H, CH3, COCH3 , OH, NO2 and NH2 had the best scored binding energies as substituent groups. Those favorable binding free energies can be justified by the intermolecular interactions between PSAs ligands and AHAS active site residues. In terms of effiency, hydrogen bonds formation can be explained by carboxylate group from the ligands and ARG-377 group from AHAS.
Os herbicidas inibidores da enzima acetohidroxiácido sintase (AHAS) apresentam alta eficiência na atividade inibitória com baixas doses de aplicação com baixa toxicidade para o homem e o meio ambiente. No entanto, várias ervas daninhas estão obtendo resistência a algumas classes de herbicidas, principalmente no caso do grupo AHAS. Portanto, um planejamento computacional adequado de novos compostos bioativos é área crucial para modelar novos herbicidas. Neste estudo, as interações enzima-herbicida foram analisadas a partir do derivado análogo do grupo pirimidinilsalicilato (PSA) que são inibidores de AHAS usando cálculos mecânicoquânticos e de docking molecular. As propriedades moleculares obtidas mostraram que o volume e a área molecular podem influenciar a capacidade de inibição do ligante, mesmo que o grupo substituinte tenha mais influência sobre este parâmetro. As propriedades eletrônicas dos orbitais HOMO podem certamente influenciar a atividade biológica devido à sua capacidade de doação de elétrons. As energias livres de ligação do ligante na enzima após o cálculo de docking variaram de -1,88 a - 4,50 kcal mol- 1 , enquanto que H, CH3, COCH3, OH, NO2 e NH2 apresentaram as melhores energias de ligação pontuadas como grupos substituintes. Estas energias livres de ligação favoráveis podem ser justificadas pelas interações intermoleculares entre ligantes de PSAs e resíduos de sítio ativo de AHAS. Em termos de eficiência, a formação de ligações de hidrogênio pode ser explicada pelo grupo carboxilato partir dos ligantes e do grupo ARG-377 de AHAS.
Dissertação (Mestrado)
Rose, Sophie. "Optimisation de la prolifération et de la différenciation des hépatocytes humains dans un nouveau modèle de culture 3D : application à l'étude des Amines Hétérocycliques Aromatiques (AHAs)". Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1B022.
Texto completoThe liver plays a major role in metabolism and elimination of xenobiotics. The development of relevant human in vitro models represents a major challenge to study the hepatic bioactivation of drugs and contaminants, the DNA alterations and their mutagenic/carcinogenic potential. These analyzes are key steps for identifying biomarkers of exposure that are essential for assessing risk in populations. In this study, we developed an original cellular model of 3D culture in collagen gels in which human hepatocytes are well organized in spheroids with an apico-basal polarity. By this approach, we demonstrated, for the first time, the ability of these 3D primary human hepatocytes to proliferate in vitro. Furthermore, a new cell cycle can be reinitiate after transient MAPKs MEK1/2-ERK1/2 signaling pathway inhibition. Under our conditions, primary and transformed hepatocytes express highly differentiated hepatic functions for several weeks of culture, and HepaRG cells differentiate after only few days of culture without addition of DMSO. In this context, we investigated the genotoxicity of a class of environmental and food contaminants, the Heterocyclic Aromatic Amines (HAA). Our results demonstrate the relevance of the collagen gel culture for the identification and quantification of DNA adducts and for acute and chronic toxicity studies in human hepatocytes. This work provides long-awaited keys for further biotechnological promising developments. Such establishment of in vitro proliferating human hepatocytes models will enable the evaluation of the mutagenic potential of environmental contaminants
Ganeshan, Dharshini. "Cell selection, characterization and regeneration of chlorsulfuron-resistant variants in asparagus". Lincoln University, 1999. http://hdl.handle.net/10182/1871.
Texto completoDegrande, Delphine. "Etude de l'expression de l'acétohydroxyacide synthase (AHAS) au cours du cycle de développement de la chicorée Witloof (Cichorium intybus L. ) et effets de l'apport exogène de valine chez la chicorée et Aradopsis Thaliana". Lille 1, 2000. https://pepite-depot.univ-lille.fr/RESTREINT/Th_Num/2000/50376-2000-240.pdf.
Texto completoDively, Ronda S. "Empathy for Captain Ahab /". View online, 1989. http://repository.eiu.edu/theses/docs/32211131012518.pdf.
Texto completoBugay, Edson Luiz. "O modelo AHAM - MI". Florianópolis, SC, 2006. http://repositorio.ufsc.br/xmlui/handle/123456789/88215.
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A utilização da hipermídia vem se tornando cada vez mais acessível e popular ao público em geral nas mais diversas áreas, tais como lazer, marketing, comércio eletrônico e principalmente no ensino onde ela permite ao usuário a exploração livre dos materiais apresentados através de diversas mídias estruturadas por links. Além de fornecer o material didático, proporciona uma forma de navegação onde o controle da interação está totalmente a cargo do usuário, permitindo que este tenha progresso de acordo com os seus interesses e objetivos e em seu próprio ritmo, sendo esta a principal característica pedagógica. De outro lado a Hipermídia Adaptativa estuda o desenvolvimento de sistemas capazes de promover a adaptação de conteúdos e recursos hipermídia vindos de qualquer fonte (bancos de dados, Internet, serviços, etc.) e apresentados em qualquer formato (texto, áudio, vídeo, etc e suas combinações) de forma individualizada a cada usuário, baseado em suas características individuais representadas em um Modelo do Usuário. O modelo AHAM-MI, proposto neste trabalho, utilizou os conceitos de regras "pedagógicas" introduzidas por Wu, Houben e De Bra no modelo AHAM, a estrutura do modelo Munich de Koch e Wirsing e acrescentou os conceitos das Inteligências Múltiplas de Gardner em seu Modelo de Adaptação e o Modelo do Usuário. No AHAM-MI, o Modelo de Adaptação seleciona o conteúdo a ser apresentado levando em conta o conhecimento do usuário sobre o assunto (como os demais sistemas existentes) e utilizando também o desenvolvimento das suas inteligências (de acordo com Gardner) para influir na adaptação, de modo que o aprendizado ocorra de acordo com as necessidades deste usuário. A base dos Sistemas de Hipermídia Adaptativa é o Modelo do Usuário onde são armazenados todas as características e o conhecimento de cada um dos usuários. No AHAM-MI, também será armazenado o nível de desenvolvimento de cada uma de suas inteligências, o que vem de encontro com a visão de uma escola ideal de Gardner como o lugar onde estudantes, de forma individual, terão suas inteligências reconhecidas e sua evolução será avaliada no contexto destas inteligências. The hypermedia's application is more and more accessible and popular to the general public in different areas like recreation, marketing, E-commerce and especially for learning, where it allows the user the free exploration of the contents through several kinds of media organized by links. Besides providing the scholastic material, it provides a kind of navigation where the interactive control is up to the user, allowing his/her progress according to his/ her own interests, objectives, and rhythm, this being the main pedagogic characteristic. On the other hand, Adaptive Hypermedia studies the development of systems capable of promoting the adaptation of contents and hypermedia resources from any source (data banks, Internet, services, etc) and presented in any format (text, audio, video, etc, and its combinations) in an individualized way for each user, based upon his/her individual characteristics represented by an User Model. The AHAM-MI model, proposed on this work, has taken advantage of the concept of "pedagogical" rules proposed by Wu, Houben and De Bra in the AHAM model, the Koch's and Wirsing's Munich model's structure and added Gardner's Multiple Intelligence concepts in the Adaptation Model and the User Model. On the AHAM-MI the Adaptation Model select the content to be presented taking into account the user's knowledge about this subject (as do other existing systems) and also the development of each of his/ her diverse intelligences (according to Gardner) to influence the adaptation, so that the learning takes place according to the user's necessities. The Adaptative Hypermedia Systems base is the User Model where all users' characteristics and knowledge are stored. On AHAM-MI, the development level of each intelligence also will be stored, which is the Gardner's vision of the ideal school as a place where students have their intelligences recognized individually and where their evolution is evaluated considering those intelligences.
Groseclose, Adam Richard. "Forming of AHSS using Servo-Presses". The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1408548321.
Texto completoSiridhara, Siradol. "AHS Maglev System Architecture". Diss., Virginia Tech, 1999. http://hdl.handle.net/10919/29219.
Texto completoPh. D.
Aviv, Aviva. "Ahad Ha-Am's concept of Jewish nationalism". Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359620.
Texto completoSlikker, Hank B. "Narrative art, unity, and theology in 1 Kings 22:1-38". Theological Research Exchange Network (TREN), 1991. http://www.tren.com.
Texto completoKershner, Kellan Scott. "Herbicide resistance in grain sorghum". Diss., Kansas State University, 2010. http://hdl.handle.net/2097/13069.
Texto completoDepartment of Agronomy
Kassim Al-Khatib
Mitchell R. Tuinstra
Sorghum acreage is declining throughout the United States because management options and yield have not maintained pace with maize improvements. The most extreme difference has been the absence of herbicide technology development for sorghum over the past twenty years. The objectives of this study were to evaluate the level of resistance, type of inheritance, and causal mutation of wild sorghums that are resistant to either acetyl-coenzyme A carboxylase (ACCase)-inhibiting herbicides or acetohydroxyacid synthase (AHAS)-inhibiting herbicides. ACCase-inhibiting herbicides used in this study were aryloxyphenoxypropionate (APP) family members fluazifop-P and quizalofop-P along with cyclohexanedione (CHD) family members clethodim and sethoxydim. The level of resistance was very high for APP herbicides but low to nonexistent to CHD herbicides. With genetic resistance to APP herbicides, the resistance factors, the ratio of resistance to susceptible, were greater than 54 to 64 for homozygous individuals and greater than 9 to 20 for heterozygous individuals. Resistance to CHD herbicides was very low with resistance factors ranging from one to about five. Genetic segregation studies indicate a single gene is the cause of resistance to APP herbicides. Sequencing identified a single mutation that results in cysteine replacing tryptophan (Trp-2027-Cys). Trp-2027-Cys has previously been reported to provide resistance to APP but not CHD herbicides. The other wild sorghum evaluated in this study was resistant to AHAS-inhibiting herbicides including imidazolinone (IM) family member, imazapyr, and sulfonylurea (SU) family member, nicosulfuron. Resistance factors in this genotype were very high, greater than 770 for the IM herbicide and greater than 500 for the SU herbicide, for both herbicide chemical families. Genetic segregation studies demonstrate that resistance was controlled by one major locus and two modifier loci. DNA sequencing of the AHAS gene identified two mutations, Val-560-Ile and Trp-574-Leu. Val-560-Ile is of unknown importance, but valine and isoleucine are similar and residue 560 is not conserved. Trp-574 is a conserved residue and Leu-574 is a known mutation that provides strong cross resistance to IM and SU herbicides. The results of these studies suggest that these sources of APP, SU, and IM resistance may provide useful herbicide resistance traits for use in sorghum.
Landry, Michael T. "The military might and activity of King Ahab". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0004/MQ46225.pdf.
Texto completoBeairsto, Shelagh Marie. "Dinjii Kat Chih Ahaa : Gwich'in notions of leadership". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0023/MQ51684.pdf.
Texto completoLaßmann, Paula, Jonathan Kießling, Stephan Mayer, Benedikt Janny y Thomas Maier. "aHa – Der adaptive Handgriff der Zukunft". Thelem Universitätsverlag & Buchhandlung GmbH & Co. KG, 2019. https://tud.qucosa.de/id/qucosa%3A36944.
Texto completoAtaie, Abdul Ahad [Verfasser]. "QRPA-Rechnungen für Ladungsaustauschanregungen an exotischen Kernen / Abdul Ahad Ataie". München : Verlag Dr. Hut, 2011. http://d-nb.info/1013526570/34.
Texto completoShelton, Lindsey Brooke. "Targeting the Hsp90/Aha1 Complex for the Treatment of Tauopathies". Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7643.
Texto completoDiaz, Infante Hernandez David Alberto. "Prediction and Prevention of Edge Fracture in Forming of AHSS". The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563371149338966.
Texto completoAha, Ulrich [Verfasser]. "Optimierung von Instandhaltungsstrategien bei unscharfen Eingangsdaten / Ulrich Aha". Kassel : Kassel University Press, 2013. http://d-nb.info/1056975121/34.
Texto completoHolmes, Joanna Louise. "Modulation of the Co-Chaperone AHA1 Affects HSP90 Function in Cancer Cells". Thesis, Institute of Cancer Research (University Of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504791.
Texto completoWills, Theodore W. "Cognitive operations and the "aha" effect : revision not confusion /". Thesis, Connect to Dissertations & Theses @ Tufts University, 2002.
Buscar texto completoAdvisr: Salvatore Soraci, Jr. Submitted to the Dept. of Psychology. Includes bibliographical references (leaves 71-73). Access restricted to members of the Tufts University community. Also available via the World Wide Web;
Kim, Hyunok. "Prediction and elimination of galling in forming galvanized advanced high strength steels (AHSS)". Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1204515296.
Texto completoGodha, Anshul. "Microstructural effects on fatigue damage evolution in advanced high strength sheet (AHSS) steels". Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/53510.
Texto completoTschuschke, Volker. "Die Edelherren von Ahaus ein Beitrag zur Geschichte des westfälischen Adels im Mittelalter /". Vreden : Landeskundliches Institut Westmünsterland, 2007. http://books.google.com/books?id=3GjaAAAAMAAJ.
Texto completoMadgwick, Sebastian O. H. "AHRS algorithms and calibration solutions to facilitate new applications using low-cost MEMS". Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.681552.
Texto completoGomes, Francisco Edvan Rodrigues. "Clonagem, expressão e estudo de 3 co-chaperonas de Leishmania braziliensis". Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/75/75132/tde-16092011-160310/.
Texto completoLeishmaniasis is an infectious disease caused by several species of Leishmania species and represents major public health problems in developing countries. In the harborer, the survival of the parasite that cause this disease depends on a special class of proteins, molecular chaperones or heat shock proteins as they are also known. The function of these proteins is to assist in protein folding, transport of proteins and many other important cellular functions. In this process the molecular chaperones are helped by their co-chaperones that play a prominent role. Among the main families of molecular chaperones, there are Hsp70 and Hsp90 with their respective co-chaperones, Hsp40 and the Aha1. The present work, initially pretended to express and purify the molecular co-chaperones Hsp40I and Hsp40II of the L. braziliensis for structural characterization by spectroscopic techniques like fluorescence and circular dichroism. However, the insolubility of these proteins, possibly caused by the presence of mutations in their DNA sequences, led to the characterization of another co-chaperone, the Aha1 of the L. braziliensis. These proteins were expressed in the cell supernatant and purified by three chromatographic steps (anion exchange, affinity for calcium ions and gel filtration). The analysis of the DNA sequence of this protein shows that it has nine Trp residues distributed between the two domains and by urea denaturation studies monitored by fluorescence techniques and circular dichroism show that they have different stabilities.
Seraphim, Thiago Vargas. "Estudo estrutural da co-chaperona Aha1 (Activator of Hsp90 ATPase 1) de Leishmania braziliensis e da sua ação sobre o ciclo funcional da Hsp90". Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-25112015-102054/.
Texto completoMolecular chaperones play a role in protein folding, complex assembly, prevention/recover of proteins from aggregates and targeting misfolded proteins to depuration. Hsp90 molecular chaperones work stabilizing proteins related to signaling pathways, cell growth, transcription and translation processes, genome stability, among others, and are essential to cell viability. In protozoa of the genus Leishmania, Hsp90s are indispensable for cell developing, adaptation and transformation. These factors make Hsp90s potential targets for pathologies treatment, such as leishmaniasis, a neglected tropical disease. Hsp90s are flexible homodimers and each protomer is divided into three domains named N, M and C. Hsp90s have a conformational cycle associated to its functional cycle and low ATPase activity, which is directed and regulated by auxiliary proteins, so-called cochaperones. Aha1 co-chaperone stimulates Hsp90 ATPase activity, participating on protein kinase and hormone receptors maturation. This work aimed to characterize the structure of the Aha1 from L. braziliensis (LbAha1) and its mechanism of interaction with the Hsp90 from the same organism (LbHsp90). LbAha1 is formed by two domains, LbAha1N and LbAha1C, connected to each other by a flexible linker. In vivo experiments identified LbAha1 and LbHsp90 as cognate proteins. Recombinant LbAha1 and its domains construct (LbAha1N and LbAha1C) were obtained pure and folded. LbAha1 is divided into two domains with dissimilar stabilities and they do not interact to each other. In spite of this they fold independently and influence each other reciprocally. LbAha1 behaves as an elongated monomer in solution and has a remarkable flexibility, with sufficient dimension to interact to LbHsp90 N and M domains. The analysis of the LbAha1-LbHsp90 interaction revealed that the association between these two proteins is enthalpically driven, occurring through electrostatic interactions in a stoichiometry of 2 LbAha1 molecules per LbHsp90 dimer. Domain mapping experiments indicated that LbAha1N and LbHsp90 M domains compose the core of the interaction and only full length LbAha1 is able to direct LbHsp90 toward a closed state. Enzyme kinetics experiments showed that only full length LbAha1 stimulates LbHsp90 ATPase activity through a positive cooperative mechanism. Thus, it is proposed that the connection between the LbAha1 domains, via linker, is essential to direct the LbHsp90 toward a closed and ATPase-competent conformational state.
Merecz, Robert Jerzy. "Jezebel's Kingdom : the Queen as a primary character in 1 Kgs 16:29 – 2 Kgs 10". Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/5468.
Texto completoEmídio, Marco. "Reconhecimento de entidades em documentos do "AHS - Arquivo Histórico Social"". Master's thesis, Universidade de Évora, 2011. http://hdl.handle.net/10174/15193.
Texto completoHilloowala, Franak. "An analysis of Ibn Abi Usaybi`ah's `Uyun al-anba' fi tabaqat al-atibba'". Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/289096.
Texto completoValoti, Elisabetta. "Genetic factors associated with anti-factor H autoantibodies in atypical hemolytic uremic syndrome (aHUS)". Thesis, Open University, 2018. http://oro.open.ac.uk/55853/.
Texto completoBäckström, Nathalie. "Wasteland : A scattered recycle station as a neighbourhood meeting spot in Ahos park, Kiruna". Thesis, Umeå universitet, Arkitekthögskolan vid Umeå universitet, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173271.
Texto completoMaga, Tara Kristen. "Unraveling the complex genetics of atypical hemolytic uremic syndrome". Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/2935.
Texto completoPalmqvist, maja. "Kan haha - leda till - aha? : Kan skrattyoga påverka kreativiteten och sinnestämningen?" Thesis, Mittuniversitetet, Institutionen för samhällsvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-11741.
Texto completoLonghurst, Leigh Anne. "The transformational potential of 'aha' moments in life coaching and beyond". Thesis, Oxford Brookes University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579546.
Texto completoKudrowitz, Barry M. (Barry Matthew). "Haha and aha! : creativity, idea generation, improvisational humor, and product design". Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/61610.
Texto completoCataloged from PDF version of thesis.
Includes bibliographical references (p. 107-116).
It is widely recognized that innovation and creativity is the new competitive battleground for product development firms. Engineers and product designers are now expected to be highly creative, prolific idea generators in addition to being analytically competent. Thus, it is of interest to study methods to improve a designer's idea generation capabilities. It is believed that wit, being spontaneous humor production, is strongly related to creativity as both involve making nonobvious connections between seemingly unrelated things. This thesis looks into the realm of humor and improvisational comedy to suggest means of enhancing creative output in blue-sky product design idea generation. We have found that the ability to quickly generate many ideas is strongly correlated (r2=.82) with being able to come up with a single, promising, creative idea. It was also found that, with appropriate training, individuals may learn to become more prolific idea generators. Furthermore, improvisational comedians were more proficient at new product idea generation than professional product designers, and methods for training comedians can be effectively adapted to product design idea generation. In a study where 84 participants (students, professional designers and improvisational comedians) took a cartoon caption humor test and a nominal product brainstorming test, we found that improvisational comedians on average produced 20% more product ideas and 25% more creative product ideas than professional product designers. Furthermore, the few individuals that were highly prolific in both creative product ideation and humorous cartoon caption production had an improvisational comedy background. Many of the games used in improvisational comedy training are intended to promote associative thinking. We designed an improvisational comedy workshop composed of these association-based games. A group of 11 subjects who participated in this workshop increased their idea output on average by 37% in a subsequent product brainstorming session. Our findings suggest that improvisational comedy games are a useful warm-up for idea generation, that prolific generation is not a domain-specific ability and that it is possible to teach creativity. Ultimately, this work can lead to the development of tools and methods that designers can use to improve their idea generation skills.
by Barry Matthew Kudrowitz.
Ph.D.
Santerre, Gabrielle. "Variabilité spatio-temporelle des THM et AHA iodés dans l'eau potable". Master's thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/32884.
Texto completoThe use of oxidants, such as sodium hypochlorite, is a very effective strategy in treating water to inactivate microorganisms responsible for several diseases. However, their use also favors the formation of disinfection by-products (SPD), such as trihalomethanes and haloacetic acids. The presence of iodide and bromide also allows the formation of other families of SPD, iodinated trihalomethanes (THMi) and iodinated haloacetic acids (AHAi). The purpose of this study is to evaluate the variability of THMi and AHAi in two small distribution networks in the Quebec City region (R1 and R2) and to measure the removal of THMi when using household filters. Water sampling took place between June and December 2017 at various points in the water treatment plant and in the distribution network. For the R1 network, mean concentrations of 2.99 μg / L in iodinated THM and 0.74 μg / L in iodinated AHA were observed, while the maximum concentration achieved was 4.02 μg / L for THMs. iodized and 2.46 μg / L for iodinated AHAs. Mean concentrations of 2.98 μg / L in iodinated THM and 0.51 μg / L in iodinated AHA were observed in Network R2, while the maximum concentration obtained was 4.05 μg / L for iodinated THMs. and 2.33 μg / L for iodinated AHAs. Iodine THM and iodinated AHA concentrations increase in the plant, particularly because of post-chlorination and passage of water through the contact basin. The iodinated THM concentrations then remain stable in the distribution network while those of the iodinated AHAs decrease. On the other hand, the removal of THMi is very effective after filtration of water on a BritaMD type household filter, with an average removal percentage of 100%.
Bellamri, Medjda. "Activation métabolique et génotoxicité des Amines Hétérocycliques Aromatiques (AHA) chez l’Homme". Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B033/document.
Texto completoHeterocyclic aromatic amines (HAA) are environmental and food contaminants, mainly formed during meat and fish cooking, but also in cigarette smoke and exhaust gaz. HAA are mutagenic in bacteria, carcinogenic in rodents and are classified as possible or probable human carcinogens by IARC. Today it is essential to characterize exposure biomarkers i.e. DNA adducts and metabolites, to assess the human risk associated with HAA. The research team has previously demonstrated that 2-amino-9H-pyrido[2,3-b]indole (AαC) form high levels of DNA adducts in human hepatocytes. These levels are greater that those derived from other HAAs. Thus, the aim of this thesis was to better understand the genotoxic potential of AαC in human. We demonstrated that in human hepatocytes, DNA adducts derived from AαC are persistent and formed at doses as low as 1nM. Moreover, we confirmed that CYP1A2 is the major enzyme implicated in the bioactivation of AαC in human liver. We have also characterized the major metabolites derived from AαC formed in human hepatocytes. This study allows, for the first time, the establishment of a correlation between the catalytic activity of CYP1A2, AαC-HN2-O-Gl formation and AαC derived DNA adducts formation. AαC-HN2-O-Gl being reactive toward DNA in vitro, our work reinforces the hypothesis that the UDP-glucuronosyltransferase (UGTs) pathway is a new bioactivation pathway for AαC in human liver. Moreover, we demonstrated the formation of HAA derived DNA adducts, especially those derived from AαC at position C8 of guanine, in activated human T lymphocytes. Taken together, our data lead to the identification of stable metabolites as well as DNA adducts which are potentials AαC exposure biomarkers in human. These biomarkers are essential for a better assessment of the genotoxic risk of AαC in human
McAllister, Carlota Pierce 1969. "This pageant which is not won: The Rabin Ahau, Maya women, and the Guatemalan nation". Thesis, The University of Arizona, 1994. http://hdl.handle.net/10150/278431.
Texto completoWang, Kai Ph D. Massachusetts Institute of Technology. "Edge fracture of AHSS sheets under out-of-plane loading followed by in-plane loading". Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/100151.
Texto completoCataloged from PDF version of thesis.
Includes bibliographical references (pages 193-198).
In recent years edge fracture has become a challenge in the manufacturing industry with the dramatical increase in the application of light-weight materials such as Advanced High Strength Steels (AHSS) and aluminum alloys. A premature edge cracking is observed in components with blanked/trimmed/pierced edges during the subsequent metal forming process. To understand the underlying physical mechanism and to establish a reliable CAE model, the thesis carries out a comprehensive experimental and numerical investigation on edge fracture of a commercially available DP780 steel sheet. The study reveals that it is the substantial plastic deformation introduced during the out-of-plane sheet blanking process that compromises the material ductility within the Shear Affected Zone (SAZ), and subsequently causes the edge to fracture prematurely under the in-plane edge stretching. To simulate the fracture behavior under such a complex a loading path, the fracture initiation is modeled using the concept of a scalar damage indicator that consists of two parts which are accumulated at different stages. The first one is accumulated during the sheet blanking process, referred to as pre-damage, while the second part is produced by the following metal forming. In such a modeling frame work, a corner stone is to determine the first part of pre-damage within the SAZ. This is achieved by a hybrid experimental and numerical method. Aided by microscopic examinations on cracked surfaces, the study shows that the pre-damage distribution within the SAZ follows an exponential function that drops from the critical value of unity at the edge surface to zero over the width of the SAZ. The obtained pre-damage is then introduced as the initial damage value during the following metal forming process. Based on a detail experimental characterization, a plasticity and fracture model is introduced to describe the material behavior under investigation. The model is based on the von Mises yield condition, a non-associated Hill'48 flow potential and an isotropic hardening law, together with the MMC fracture locus description with dependence on both stress triaxiality and Lode angle parameter. The proposed model successfully predict edge fracture in numerical simulation.
by Kai Wang.
Ph. D.
Alodail, Abdullah Kholifh. "Students’ Attitudes Toward the Use of Hearing Aids in Al-Ahsa, Kingdom of Saudi Arabia". Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1306953223.
Texto completoAlshawa, Majd. "Contribution à la cartographie mobile : développement et caractérisation d’un système basé sur un scanner laser terrestre". Strasbourg, 2009. https://publication-theses.unistra.fr/public/theses_doctorat/2010/ALSHAWA_Majd_2010.pdf.
Texto completoMobile mapping technology has been developing with the growing demand of three-dimensional urban and peri-urban data. This thesis approach is based on the design of a low cost terrestrial mobile mapping system with the adaptation of a Terrestrial Laser Scanner for low dynamics. Our goal is not to compete in performance with commercial systems but rather to appropriate scientific and technological skills which will help in proposing solutions in the field of mobile mapping. Necessary operational settings, such as synchronization and calibration are explained. Then, some methods based on the adjustment of polynomial models are developed according to the traveled paths. Data from various sensors (GPS/ AHRS/TLS) are filtered and tested before their integration by direct georeferencing equation in order to produce a correct point cloud. A comprehensive study on the influence of errors of each sensor on the resulting point cloud is established. The theoretical precision is compared with reference data in order to validate the error analyze. A digital calibrated camera is integrated in the system as a navigation sensor. A photogrammetric solution is proposed to improve the accuracy of the orientation and the position calculated by integrating GPS/ AHRS. At the end of this thesis, an approach towards automatic modeling is proposed to make use of the geometry and precision provided by the system. The designed prototype supplies point clouds whose precision is about 10 to15 cm at the average distance of 20 m
Ozgeneci, Ercin Mehmet. "Mems Sensor Based Underwater Ahrs(attitude And Heading Reference System) Aided By Compass And Pressure Sensor". Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614619/index.pdf.
Texto completoBorasi, Luciano. "Investigation of the Effect of Different “Q&P” Parameters on the Mechanical Properties of AHSS". Thesis, Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-70060.
Texto completoAykas, Berk. "Evaluation of Edge Fracture in Flanging Advanced High Strength Steel (AHSS) Using the Double Bending Test". The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1557210237260137.
Texto completoIssa, Danielle Léa. "Testing and prediction of failure of AHSS sheets at Die Radius and Sidewall using novel fracture apparatus". Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/50582.
Texto completoIncludes bibliographical references (p. 109-110).
A new apparatus was constructed to fit the Impact and Crashworthiness Lab's dual actuator custom-made loading frame that has force or position control. The strip is pre-bent into an elbow configuration and fastened by the vertical and horizontal grips. One end of the metal strip is subjected to a predefined constant restraining force, while the other is pulled with a constant velocity to cause a rolling deformation over a prescribed die radius. A series of 40 tests, using TRIP 690 steel, was performed for various combinations of die radius, magnitude of pretension, and die/strip friction. Based on the experimental results, a deformation and failure map was generated, showing ranges of safe forming. Depending on the interplay of different parameters, fracture occurs either on the sidewall or on the die radius, in which case, a close examination of the surface reveals it is slant. Combined theoretical, experimental, and numerical analyses are presented. The present study confirmed previous results published in the literature [1,5] that the pretension needed to fracture a metal strip increases with die radius and tends asymptotically to a constant value. What is new in the present investigation, however, is that this relationship has been quantified for a particular steel of interest for automotive applications. In addition, a method was outlined to predict fracture through finite element simulations, which was lacking in the earlier treatment of a similar problem.
by Danielle Léa Issa.
S.M.
Gupta, Tanmay. "Predicting and Reducing Springback in Bending of an Aluminum Alloy and Selected Advanced High Strength Steels (AHSS)". The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555599407775667.
Texto completoKarlsson-Schagerström, Eva y Ann-Marie Melin. "Kan bedömningsinstrumentet AHA användas för att göra tillförlitliga bedömningar på barn med handdysmeli?" Thesis, Örebro University, Academy of Health Science, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-2149.
Texto completo