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Bin-Jaliah, Ismaeel. "Natural Hypoxia is Not a Limiting Factor in Evaluating the Novel Arylidene Derivative MLT-401 Against an In Vitro Colorectal Cancer Model". Cellular Physiology and Biochemistry 46, n.º 5 (2018): 2082–89. http://dx.doi.org/10.1159/000489448.
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Background/Aims: Cancer cells in vivo develop resistance to many anti-tumor drugs. One known factor to influence such drug resistance is hypoxia, which is an important component of the tumor microenvironment. Standard cancer lines mostly do not exhibit a cellular hypoxic microenvironment and there is a paucity of information on the efficacy of lead molecules in both cellular- and environment-induced hypoxic conditions. Therefore, in the present study, we have evaluated the efficacy of the arylidene derivative MLT-401, a lead molecule showing activity against colorectal cancer model using the HCT 116 cell line and CCD-80-C control cells in normoxic and natural (marginal) hypoxic conditions, which is usually observed in high-altitude regions. Methods: The efficacy of MLT-401 on HCT 116 and CCD-80-C cells were tested in both normoxia and marginal hypoxia conditions. MTT assay was used to evaluate cell proliferation, Annexin V binding assay for apoptotic cell quantification and PI staining for cell cycle were done by flow cytometry. Induction of pro-apoptotic marker BAX and anti-apoptotic Bcl-2 were assessed by western blot. Bcl-2/BAX ratio was calculated based on protein expression by western blotting and bands were quantified by Image J software. Results: Analysis of cell proliferation showed an average 10-fold reduction in the inhibition of HCT 116 cells in hypoxic conditions with approximately 500 nM MLT-401, while there was no significant change noted in marginal hypoxic conditions. A proportionate increase in the number of apoptotic cells and large M4 fraction of 10.5% and 26.7% of HCT116 against 6.3% of control cells in cell cycle assessment with MLT-401 concentrations ranging from 250 to 500 nM respectively clearly demonstrated anti-cancer activity. A Bcl-2/BAX ratio of < 1 showed that the induction of apoptosis was the gross mechanism underlying the inhibition of HCT 116 cells by MLT-401. Conclusion: Collectively, these results show MLT-401 as an effective anti-colorectal cancer lead molecule irrespective of normoxia or natural hypoxia.
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Cruz, Rosângela, Ady BARROS, Alba Valeria Alves Ignácio y Marcelo Sergio da Luz Cruz. "Percepção das crianças da Escola Municipal “Centro de Promoção Educacional” do Estatuto Criança e Adolescente". Concilium 22, n.º 4 (8 de junio de 2022): 933–44. http://dx.doi.org/10.53660/clm-401-500.
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Apresenta-se no Artigo o resultado da Pesquisa Bibliográfica e de Campo desenvolvida durante o Curso Gestão Escolar, na Escola Municipal de Ensino Fundamental, do Centro de Promoção Educacional, de Apiacás-MT, a percepção das crianças, a partir dos 10 anos, sobre o que sabem dos seus direitos previstos em Lei, especialmente no ECA. Foi de suma importância a pesquisa para a Gestão Escolar rever seu Projeto Político Pedagógico, bem como a sua relação compromisso ético, cidadão com as crianças/adolescentes e seus familiares/comunidade escolar.
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Yuliani, Yuliani, Ika Friscila y Frani Mariana. "KONSUMSI JANTUNG PISANG TERHADAP RERATA PENINGKATAN PRODUKSI ASI PADA IBU MENYUSUI". Jurnal Kebidanan Khatulistiwa 9, n.º 2 (11 de diciembre de 2023): 52. http://dx.doi.org/10.30602/jkk.v9i2.1210.
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Latar belakang : ASI eksklusif sangat bermanfaat bagi bayi, dampak yang dapat terjadi apabila bayi tidak diberikan ASI eksklusif adalah meningkatnya angka kesakitan dan kematian bayi. Pemberian ASI eksklusif 6 bulan merupakan investasi terbaik bagi kesehatan dan kecerdasan anak. Jantung pisang merupakan bagian dari tanaman pisang yang dimanfaatkan untuk meningkatkan produksi ASI. Dipilih karena harganya murah dan sangat mudah didapatkan. Tujuan: Mengetahui konsumsi jantung pisang terhadap rerata peningkatan produksi ASI pada ibu menyusui di Wilayah Kerja Puskesmas Murung Pudak. Metode: Menggunakan eksperimen semu dengan rancangan berbentuk pretest-posttest with control group design menggunakan dua jenis perlakuan. Kelompok konsumsi jantung pisang sebanyak 200 gr 2 kali sehari. Hasil Penelitian: Rerata produksi ASI sebelum perlakuan rentang 401-500 cc dengan nilai rerata 496,6667, rerata produksi ASI sesudah perlakuan rentang 801-900 cc dengan nilai rerata 816,6667, rerata produksi ASI pada kelompok kontrol rentang 401-500 cc dengan nilai rerata 453,333 pada ibu menyusui di Wilayah Kerja Puskesmas Murung Pudak. Kesimpulan : Konsumsi jantung pisang terbukti meeningkatkan produksi ASI pada kelompok perlakuan ibu menyusui di wilayah kerja Puskesmas Murung Pudak.
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Begg, Gavin A. "Reproductive biology of school mackerel (Scomberomorus queenslandicus) and spotted mackerel (S. munroi) in Queensland east-coast waters". Marine and Freshwater Research 49, n.º 3 (1998): 261. http://dx.doi.org/10.1071/mf97187.
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Spatial and temporal spawning patterns of school mackerel (Scomberomorus queenslandicus) and spotted mackerel (S. munroi) in Queensland east-coast waters, Australia, (16˚S to 28˚S), were examined to provide reproductive parameters required for the management and protection of spawning stocks. School mackerel spawned along the Queensland coastline from October to January. Female school mackerel were sexually mature between 401 and 450 mm, and males between 351 and 400 mm LCF (length to caudal fork). In contrast, spotted mackerel spawned in northern Queensland waters from August to October. Females were between 451 and 500 mm, and males 401 and 450 mm LCF at first maturity. Both species were found to be dioecious. Differential spawning patterns of school and spotted mackerel may help the species coexist and maintain the integrities of the species and their respective stock structures.
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Xuzhang, Wendi, Huayan Huang, Yongfeng Yu, Lan Shen, Ziming Li y Shun Lu. "Treatment strategies based on different oligoprogressive patterns after immunotherapy failure in metastatic NSCLC". Therapeutic Advances in Medical Oncology 15 (enero de 2023): 175883592311563. http://dx.doi.org/10.1177/17588359231156387.
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Background: Oligoprogressive disease is recognized as the overall umbrella term; however, a small number of progressions on imaging can represent different clinical scenarios. This study aims to explore the optimal treatment strategy after immunotherapy (IO) resistance in advanced non-small-cell lung cancer (NSCLC), especially in personalized therapies for patients with different oligoprogressive patterns. Methods: Based on European Society for Radiotherapy and Oncology/European Organization for Research and Treatment of Cancer consensus, metastatic NSCLC patients with cancer progression after IO resistance were divided into four patterns, repeat oligoprogression (REO, oligoprogression with a history of oligometastatic disease), induced oligoprogression (INO, oligoprogression with a history of polymetastatic disease), de-novo polyprogression (DNP, polyprogression with a history of oligometastatic disease), and repeat polyprogression (REP, polyprogression with a history of polymetastatic disease). Patients with advanced NSCLC who received programmed cell death-1/programmed cell death ligand-1 inhibitors between January 2016 and July 2021 at Shanghai Chest Hospital were identified. The progression patterns and next-line progression-free survival (nPFS), overall survival (OS) were investigated stratified by treatment strategies. nPFS and OS were calculated using the Kaplan–Meier method. Results: A total of 500 metastatic NSCLC patients were included. Among 401 patients developed progression, 36.2% (145/401) developed oligoprogression and 63.8% (256/401) developed polyprogression. Specifically, 26.9% (108/401) patients had REO, 9.2% (37/401) patients had INO, 27.4% (110/401) patients had DNP, and 36.4% (146/401) patients had REP, respectively. The patients with REO who received local ablative therapy (LAT) had significant longer median nPFS and OS compared with no LAT group (6.8 versus 3.3 months; p = 0.0135; OS, not reached versus 24.5 months; p = 0.0337). By contrast, there were no nPFS and OS differences in INO patients who received LAT compared with no LAT group (nPFS, 3.6 versus 5.3 months; p = 0.3540; OS, 36.6 versus 45.4 months; p = 0.8659). But in INO patients, there were significant longer median nPFS and OS using IO maintenance by contrast with IO halt treatment (nPFS, 6.1 versus 4.1 months; p = 0.0264; OS, 45.4 versus 32.3 months; p = 0.0348). Conclusions: LAT (radiation or surgery) is more important for patients with REO while IO maintenance plays a more dominant role in patients with INO.
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พงษ์สวัสดิ์, สืบพงษ์ y ธีรวิชญ์ วงษา. "การสำรวจแปลงปลูกป่าชาวบ้านในพื้นที่ศูนย์พัฒนาโครงการหลวงหมอกจ๋าม ด้วยเครื่องกำหนดพิกัดบนพื้นโลกด้วยดาวเทียมแบบมือถือ". Suranaree Journal of Social Science 15, n.º 2 (21 de septiembre de 2021): 41–58. http://dx.doi.org/10.55766/midf3554.
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การวิจัยนี้มีวัตถุประสงค์เพื่อ 1) สำรวจแนวเขตแปลงปลูกป่าชาวบ้านด้วยเครื่องกำหนดพิกัดบนพื้นโลกด้วยดาวเทียมแบบมือถือ 2) จัดทำฐานข้อมูลแนวเขตแปลงปลูกป่าชาวบ้านด้วยระบบสารสนเทศภูมิศาสตร์ และ 3) วิเคราะห์อัตราการรอดตายของต้นพันธุ์ และความสัมพันธ์กับระยะห่างจากบ้านของเกษตรกร ความสูง และความลาดชัน ประชากรในการศึกษาครั้งนี้คือ เกษตรกรที่เป็นสมาชิกโครงการปลูกป่าชาวบ้านของศูนย์พัฒนาโครงการหลวงหมอกจ๋าม อำเภอแม่อาย จังหวัดเชียงใหม่ จำนวน 52 ราย ผลการวิจัยพบว่า การใช้เครื่องกำหนดพิกัดบนพื้นโลกด้วยดาวเทียมแบบมือถือเข้าไปสำรวจแนวเขตแปลงปลูกป่าของเกษตรกรทั้ง 52 ราย นำต้นพันธุ์ไปปลูกในที่ดินของตนเองจำนวน 61 แปลง รวมจำนวนต้นพันธุ์ 39,948 ต้น การปลูกแบ่งได้เป็น 2 แบบ คือ การปลูกแบบแนวรั้ว คิดเป็นร้อยละ 43 และการปลูกแบบแปลง คิดเป็นร้อยละ 57 โดยค่าพิกัดที่ได้จากเครื่องกำหนดพิกัดบนพื้นโลกด้วยดาวเทียมแบบมือถือมีความคลาดเคลื่อนเฉลี่ย 7.36 เมตร จากการวิเคราะห์ด้วยระบบสารสนเทศภูมิศาสตร์พบว่าทำเลที่ตั้งของแปลงปลูกป่าชาวบ้านมีการกระจุกตัวอยู่ใกล้กับชุมชน ที่มีระดับความสูงระหว่าง 401-500 เมตร จากระดับน้ำทะเลปานกลาง และมีร้อยละความลาดชันระหว่าง 35-50 ต้นจันทร์ทองเทศมีอัตราการรอดตายสูงที่สุด คือร้อยละ 77.59 อัตราการรอดตายมีความสัมพันธ์ในทิศทางเดียวกับระยะห่างจากบ้านของเกษตรกร ความสูง และความลาดชัน โดยมีค่าสหสัมพันธ์ (r) เท่ากับ 0.27 0.17 และ 0.26 ตามลำดับ แต่ค่าสัมประสิทธิ์การตัดสินใจ (r2) เท่ากับ 0.07 0.03 และ 0.07 จึงสรุปได้ว่าอัตราการรอดตายของต้นพันธุ์อาจไม่มีระดับความสัมพันธ์มากกับระยะห่างจากบ้านของเกษตกร ความสูง และความลาดชัน
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الصرصور, إبراهيم علي, محمد علي قاسم y صابر السيد منصور. "امتزاز بعض أيونات المعادن الثقيلة على سطح طفلة مدينة درنة – ليبيا". Al-Mukhtar Journal of Sciences 20, n.º 1 (31 de diciembre de 2008): 123–33. http://dx.doi.org/10.54172/mjsc.v20i1.825.
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تعد طفلة الكاولينيت من المواد رخيصة الثمن وتتواجد بوفرة كبيرة كما أن لها خواص سطحية مميزة تجعلها من المواد المازة الجيدة لذا تم أخذ عينات من طفلة الكاولينيت من مدينة درنة ومعالجتها حراريا عند درجة حرارة الغرفة و200 و 500 درجة مئوية . ولدراسة امتزاز العناصر الثقيلة على سطح الطفلة تم تحضير محاليل مائية من بعض أملاح الفلزات (النحاس ، النيكل والخارصين) وأظهرت نتائج أيزوثرم الإمتزاز أن السعة القصوى للإمتزاز هي 672 ، 620 و 589 (ppm) لأيونات النحاس والنيكل والخارصين على الترتيب بالنسبة لعينة الطفلة غير المعالجة حراريا ، وكانت 672 ، 500 و 459 (ppm) لعينة الطفلة المعالجة عند 200 درجة مئوية وكانت 427 ، 401 و 333 (ppm) لعينة الطفلة المعالجة عند 500 درجة مئوية . ومن خلال الدراسة كان ترتيب إمتزاز أيونات العناصر على الصورة التالية : النحاس > النيكل > الخارصين كما أن عينة الطفلة غير المعالجة حراريا أظهرت أعلى امتزاز وبمقارنة أيزوثرمات الإمتزاز لكل من فرندلك ولانجمير أظهرت النتائج أن امتزاز هذه العناصر يتبع أيزوثرم لانجمير نظرا لأنه يظهر أقل حيود .
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Hung-Lung, C., T. C. Chen, M. C. Tsai y Y. L. Chen. "Adsorption characteristics of benzene on biosolid adsorbent". Water Science and Technology 47, n.º 1 (1 de enero de 2003): 83–87. http://dx.doi.org/10.2166/wst.2003.0022.
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This study selected biosolids from a petrochemical wastewater treatment plant as the raw material. The sludge was immersed in 0 to 5 mol l-1 of ZnCl2 solutions and pyrolyzed at different temperatures. When the sludge was pyrolyzed for 30 min at temperatures of 400, 500, 600, and 700°C, the corresponding surface area of the biosolid adsorbent was 46, 401, 921, and 727 m2/g, respectively. Pore size analysis indicated that the mesopore (20 to 500 Å) contributed more than the macropore and micropore in the sludge pyrolytic residue. When the benzene influent concentration was 800 ppmv, the adsorption capacity ranged from 59 to 164 mg/g for different biosolid adsorbents. A larger BET surface area and smaller average pore diameter yielded a larger benzene adsorption capacity.
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Miura, Toshihiro y Atsushi Kato. "Hypoglycemic Action of Embelia madagascariensis in Normal and Diabetic Mice". American Journal of Chinese Medicine 25, n.º 02 (enero de 1997): 169–73. http://dx.doi.org/10.1142/s0192415x97000196.
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The hypoglycemic effect of Embelia madagascariensis (Myrsinaceae) was investigated in both normal and streptozotocin-induced diabetic mice. The methanol extract of leaves of Embelia madagascariensis (EL)(500 mg/kg) reduced the blood glucose of normal mice from 206 ± 9 to 137 ± 10 mg/100 ml 4 hours after intraperitoneal administration (P<0.001), and also significantly lowered the blood glucose of streptozotocin-induced diabetic mice from 570 ± 29 to 401 ± 59 mg/100 ml under similar conditions (P<0.05). EL also suppressed epinephrine-induced hyperglycemia in mice (control vs EL, P<0.01).
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Roy, Indranil, Manuel Marya, David Susnitzky y Hong Qi Deng. "Comparative Performance of Three High-Strength Ni-Cr-Mo Alloys in Oilfield Simulated H2S Environment". Materials Science Forum 783-786 (mayo de 2014): 1857–62. http://dx.doi.org/10.4028/www.scientific.net/msf.783-786.1857.
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Three Ni-Cr-Mo alloys with 140ksi minimum yield strength, namely 625Plus, 718, and 945X were tested in selected sour environments to evaluate and rank their environmentally-assisted cracking susceptibility. The testing revealed that none of the alloys, stressed to 90% of their actual yield point, cracked as a result of an agressive 30-day NACE level VII-modified environment (401 ± 9 oF, 500 psia H2S, 500 psia CO2 and 151,700 mg/liter chlorides). In a complementary attempt to rank the alloy cracking susceptiblity, quasi-static strain rate (SSR) tests per NACE TM0198-2004 were conducted in a modified H2S-saturated NACE TM0177 Solution A. Following a critical analysis of parameters such as time-to-failure (TTF), percentage reduction in ductility (%ε), percentage reduction of cross-sectional area (% RA) and fractomicrographs, 625Plus was confirmed to outperform its counterparts while some evidence of hydrogen embrittlement was found on 945X.
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Rumzhum, NN, MM Rahman, AA Sharukh, SA Chowdhury y MN Pervin. "In vitro antioxidant and antinociceptive potentialities of methanolic extract of Litsea glutinosa". Bangladesh Journal of Scientific and Industrial Research 47, n.º 4 (6 de marzo de 2013): 401–6. http://dx.doi.org/10.3329/bjsir.v47i4.14069.
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The methanolic extract of Litsea glutinosa (Lauraceae) was evaluated for in vitro antioxidant activity by determination of hydrogen peroxide scavenging activity, total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test and in vivo antinociceptive effect in acetic acid induced writhing model in swiss albino mice. The results revealed the presence of pronounced antioxidant property as compared with ascorbic acid used as standard and a dose-dependent (250 and 500 mg/kg) analgesic effect. The antioxidant and antinociceptive properties observed seem to be in good accordance with the traditional uses of Litsea glutinosa. Bangladesh J. Sci. Ind. Res. 47(4), 401-406, 2012 DOI: http://dx.doi.org/10.3329/bjsir.v47i4.14069
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Schukina, Olga, Maksud Abdukarimov y Albina Valieva. "Creating a 3D terrain model for the territory of the Hasti-Imom ensemble in Tashkent, Uzbekistan". E3S Web of Conferences 497 (2024): 02024. http://dx.doi.org/10.1051/e3sconf/202449702024.
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The purpose of this work is to create a three-dimensional model of the terrain on the territory of the Hasti-Imam ensemble of the city of Tashkent (Uzbekistan), using a Geoscan 401 multi-rotor unmanned aerial vehicle and a modern photogrammetric product Agisoft Metashape. Four flights were performed at this facility using a Geoscan 401 quadcopter. Aerial photography was carried out at different heights (from 40 m to 100 m) and with different inclinations of the aerial camera (45°, 60°, 90°) in order to display all elements of the ensemble in more detail. Aerial photography was carried out at a scale of 1:500 using a SonyDSC-RX1 digital aerial camera with a focal length of 50 mm. The longitudinal overlap of aerial photographs was from 70% to 80% and, accordingly, the transverse overlap was also from 70% to 80%. The number of aerial photographs at the site was 936 pieces. The length of all air routes was 65.9 km. The area of the filmed object was 14 hectares.The processing of unmanned aerial photography and the construction of a three-dimensional model of the terrain on the territory of the Hasti-Imam ensemble in Tashkent, Uzbekistan was carried out in the modern photogrammetric complex Agisoft Metashape.
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Messier, Christian y Pierre Bellefleur. "Variations des propriétés spectrales des feuilles au cours de la croissance du bouleau jaune". Canadian Journal of Botany 65, n.º 8 (1 de agosto de 1987): 1682–86. http://dx.doi.org/10.1139/b87-230.
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A yellow birch stand was divided into five age classes (1–5, 6–10, 11–20, 21–40, and >40 years old) to evaluate variations in spectral properties of leaves during the growth of yellow birch. Shade leaves of 1 to 5 year-old seedlings absorb significantly less, while they reflect and transmit significantly more than shade leaves of the other age classes in the 390–725 nm wavelength range. Absorptance differences are more striking in the green and the yellow between 501 and 590 nm (0.067–0.091) than in the orange and the red between 591 and 700 nm (0.041–0.054) and the violet and the blue between 401 and 500 nm (0.017–0.020).
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Ali, Zulfiqar, Afsheen ,. Akbar, Nida ., Sidra Tul Huda, Faiza Habib y Aamna Habib. "Mitochondrial Ferritin in Erythroid Cells from patients with Myelodysplastic Syndrome". Pakistan Journal of Medical and Health Sciences 17, n.º 2 (28 de febrero de 2023): 142–44. http://dx.doi.org/10.53350/pjmhs2023172142.
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Background: The Myelodysplastic syndrome (MDS) is extremely fatal illness whither anaemia is insensitive to any medical management. Aim: In present research, effect of levels of ferritin in serum lying on prospects and continued existence was scrutinize in MDS subjects with no previous record of blood transfuse. Study design: Retrospective. Methods: These cases (MDS) were alienated into two groups, according to their serum ferritin levels. Sample size of 58 cases of MDS calculated according to online service “Select Statistical Services Ltd” comparing two means. Results: The time of endurance mean was 5.09 years ± 4.8 months. Median ferritin levels of serum ferritin were 358 ng /ml. The plasma ferritin level is related with higher rate of mortality with levels as 500 ng/ml. The ROC part for Serum ferritin was 0.721 by means of a cut-off range of 401; susceptibility and explicitness. were 71.7% and 69.1%, correspondingly) P=0.002. In attendance were 33 subjects with value of ferritin is ≥ 500 ng/ml. Patients with serum ferritin values ≥ 500 ng/mL had lower survival expectancy. Ferritin ≥ 500 ng/mL be related with seven folds augmented death rates (P = 0.001). Practical Implication: In MDS iron chelation is not well-known, for that reason the overall survival is not good. The iron chelation might encompass a favorable outcome on survival of MDS. Conclusion: Even though 1000ng/ml ferritin value in the beginning of chelation therapy is adequate, reduced survival expectancy will be associated with high levels of serum ferritin. Keywords: Myelodysplastic syndrome, ferritin, chelation, ring sideroblast, isoniazid, penicillamine
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Napitupulu, Manaor, Melita Aditya Sari y Sara Sonnya Ayutthaya. "The risk factors of Chronic Kidney Disease in type 2 Diabetes Mellitus". Health Science Journal of Indonesia 9, n.º 1 (15 de octubre de 2018): 19–24. http://dx.doi.org/10.22435/hsji.v9i1.474.
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Latar belakang: Penderita Diabetes melitus (DM) yang tidak ditangani dengan baik akan menimbulkankomplikasi Nefropati Diabetika sebagai penyebab utama dari Gagal Ginjal terminal. Tujuan penelitian iniadalah untuk menentukan faktor risiko Gagal Ginjal pada pasien DM tipe 2.
Metode: Desain penelitian ini adalah potong lintang yang meneliti faktor risiko Gagal Ginjal pada pasienrawat jalan DM tipe 2 di bagian penyakit dalam RSUD kota Bekasi mulai tanggal 01 September 2015sampai dengan 30 September 2015. Data primer dikumpulkan melalui kuesioner terstruktur. Sampeldalam penelitian ini berjumlah 246 purposive individual sampling (107 pria dan 139 wanita). Analisisdata mempergunakan SPSS versi 21 dan EPISTAT versi 3.3
Hasil: Faktor risiko gagal ginjal yang terkait dengan perjalanan penyakit DM tipe 2 adalah: umur saatdidiagnosis DM 36-54 tahun (ORa=2.41; p=0.01); menderita DM 6-10 tahun dan lebih dari 10 tahunsetelah didiagnosis (ORa=4.30; p=0.000 vs ORa=18.54; p=0.000). Dibandingkan dengan kadar glukosadarah awal 201-300 mg/dl, responden dengan kadar gula darah awal 401-500 mg/dl dan lebih dari 500mg/dl masing-masing berisiko Gagal Ginjal 5.63 kali dan 11.11 kali (p=0.000 vs p=0.000). Kadar glukosadarah tertinggi >500 mg/dl berisiko Gagal Ginjal 5.86 kali dibandingkan dengan 201-300 mg/dl (p=0.000).
Kesimpulan: Usia pada saat didiagnosis DM, lamanya menderita DM setelah didiagnosis, kadar glukosadarah awal dan kadar glukosa darah tertinggi >500 mg/dl merupakan faktor-faktor risiko Gagal Ginjal
Kata kunci: Faktor risiko, progresi DM tipe 2, Gagal Ginjal
AbstractBackground: A condition when Diabetes Mellitus patients does not get an adequate medical treatment,will cause Diabetic Nephropathy, which is a major cause of a terminal Chronic Kidney Disease (CKD).The objective of this study is to determine risk factors of CKD in patients with type 2 DM.
Methods: Design of this study was a cross sectional, that investigated risk factors of CKD in outpatientswho suffered type 2 DM at Department of Internal Medicine of Bekasi General Hospital from the 1st ofSeptember to the 30th of September, 2015. Primary data was collected through structured questionnaires.Sample in this study was 246 purposive individual sampling (107 male and 139 female). The data analysisused SPSS version 21 and EPISTAT version 3.3.
Results: The risk factors of CKD related to progressive of Diabetes Mellitus type 2 disease were: age atfirst diagnosed of DM 36-54 years (ORa=2.41; p=0.01), suffering DM 6-10 years and more than 10 yearsafter being diagnosed (ORa=4.30; p=0.000 vs ORa= 18.54; p=0.000 ). Referring to initial blood glucoselevels of 201-300 mg/dl, the respondents with initial blood glucose levels of 401-500 mg/dl and more than500 mg/dl had the risk of CKD 5.63 times and 11.11 times respectively (p=0.000 vs p=0.000). The highestblood glucose levels >500 mg/dl had the risk of CKD 5.86 times compared with 201-300 mg/dl (p=0.000).
Conclusion: Age at first diagnosed of DM, duration of suffering DM post diagnosed, initial blood glucoselevels, and the highest blood glucose levels >500 mg/dl were the risk factors of CKD.
Keywords: Risk factors, progressive of type 2 DM, CKD
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Daniella, Daniella y Achmad Amri Dharma Wangsa. "Leveraging Integrated Bike-Sharing with Existing Bus Rapid Transit (BRT) to Reduce Motor Vehicle in Central Jakarta Municipal". Geoplanning: Journal of Geomatics and Planning 6, n.º 1 (30 de agosto de 2019): 13. http://dx.doi.org/10.14710/geoplanning.6.1.13-20.
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Jakarta is one of the most congested cities in the world due to a plethora of motor vehicles used in the city. One of the government actions to address the issue is by implementing Bus Rapid Transit (BRT) as an alternative public transportation mode. However, according to the convenience walking distance standard, the BRT coverage the inhabitant to choose motor vehicle rather than walking. This paper purposes Bike-Sharing as the smart transportation mode to overcome such issue and predict the three potential places to establish sharing-bike stations according to the convenience walking distance standard. In this paper the walking distance is classified into 100 mater range (300 meter, 400 meter and 500 meter) projected using the euclidean distance principle. As the result for 300 meter standard, there are 809 potential bike-sharing stations consist of 164 main stations and 645 feeder stations, while the 400 meter standard needs 541 potential stations with 140 stations serve the BRT station directly and 401 stations as the feeder. Furthemore, with 500 meter standard, 359 stations consist of 131 main stations and 228 feeder stations is needed.
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Umboh, Iwan Sixtus. "Insect Diversity In Forest Of Mount Klabat, Kauditan Subdistrict North Minahasa Regency". Indonesian Biodiversity Journal 1, n.º 1 (10 de noviembre de 2020): 14–21. http://dx.doi.org/10.53682/ibj.v1i1.141.
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This study aims to assess The population and insect diversity in the Forest of Klabat. Sequences of this study consisted of determining the location of the sample, the sample unit, and forest. This research was conducted using survey methods, identification, and analysis data. The resulting study showed that insect populations and diversity obtained from the forest of Klabat is a total of 190 individuals consisting of 29 orders and 23 families, with the amount of each individual as follows: 34 Diptera, Hymenoptera 25, 21 Coleoptera, Lepidoptera 18, .and Orthoptera 5. The population the highest of the forest that is on the order Diptera Family Lauxamidae. Insect Diversity in the forest of Klabat at altitude 301 -400 masl is H. =4,76, and in the forest of Klabat at altitude 401 – 500 masl is H. = 2,31.
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Lucey, J. F., C. A. Rowan, P. Shiono, A. R. Wilkinson, S. Kilpatrick, N. R. Payne, J. Horbar, J. Carpenter, J. Rogowski y R. F. Soll. "Fetal Infants: The Fate of 4172 Infants With Birth Weights of 401 to 500 Grams--The Vermont Oxford Network Experience (1996-2000)". PEDIATRICS 113, n.º 6 (1 de junio de 2004): 1559–66. http://dx.doi.org/10.1542/peds.113.6.1559.
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Basu, Mohua, Lisa Petgrave-Nelson, Kayla D. Smith, Jennie P. Perryman, Kevin Clark, Stephen O. Pastan, Thomas C. Pearson, Christian P. Larsen, Sudeshna Paul y Rachel E. Patzer. "Transplant Center Patient Navigator and Access to Transplantation among High-Risk Population". Clinical Journal of the American Society of Nephrology 13, n.º 4 (26 de marzo de 2018): 620–27. http://dx.doi.org/10.2215/cjn.08600817.
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Background and objectivesBarriers exist in access to kidney transplantation, where minority and patients with low socioeconomic status are less likely to complete transplant evaluation. The purpose of this study was to examine the effectiveness of a transplant center–based patient navigator in helping patients at high risk of dropping out of the transplant evaluation process access the kidney transplant waiting list.Design, setting, participants & measurementsWe conducted a randomized, controlled trial of 401 patients (n=196 intervention and n=205 control) referred for kidney transplant evaluation (January 2013 to August 2014; followed through May 2016) at a single center. A trained navigator assisted intervention participants from referral to waitlisting decision to increase waitlisting (primary outcome) and decrease time from referral to waitlisting (secondary outcome). Time-dependent Cox proportional hazards models were used to determine differences in waitlisting between intervention and control patients.ResultsAt study end, waitlisting was not significantly different among intervention (32%) versus control (26%) patients overall (P=0.17), and time from referral to waitlisting was 126 days longer for intervention patients. However, the effectiveness of the navigator varied from early (<500 days from referral) to late (≥500 days) follow-up. Although no difference in waitlisting was observed among intervention (50%) versus control (50%) patients in the early period (hazard ratio, 1.03; 95% confidence interval, 0.69 to 1.53), intervention patients were 3.3 times more likely to be waitlisted after 500 days (75% versus 25%; hazard ratio, 3.31; 95% confidence interval, 1.20 to 9.12). There were no significant differences in intervention versus control patients who started evaluation (85% versus 79%; P=0.11) or completed evaluation (58% versus 51%; P=0.14); however, intervention patients had more living donor inquiries (18% versus 10%; P=0.03).ConclusionsA transplant center–based navigator targeting disadvantaged patients improved waitlisting but not until after 500 days of follow-up. However, the absolute effect was relatively small.
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Videnovic, Zivorad, Zoran Dumanovic, Milena Simic, Jelena Srdic, Milosav Babic y Vesna Dragicevic. "Genetic potential and maize production in Serbia". Genetika 45, n.º 3 (2013): 667–77. http://dx.doi.org/10.2298/gensr1303667v.
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Genetic potential of maize hybrids grown in Serbia is 10-15 t ha-1 , while the average yields are considerably lower. There are many reasons for this. At first, it is well known that drought is present often in some parts of country. Some soils are not suitable in the same degree for intensive maize production, application of mineral fertilizers is insufficient, mechanization is outdated and arable farms are small and fragmented. During the period 19652012 high variations in precipitation were present during the maize vegetation. The yearly average precipitation sum was 688.9 mm, with 397.5 mm during vegetation. According to precipitation amount, years were divided into groups: I 200-300 mm 7, (15%); II 301-400 mm 21, (44%) and III 401-500 mm 14, (30%), and IV in 5 years (11%) more than 500 mm of precipitation was present. The highest average yield in Serbia was achieved in 1991 (5.95 t ha-1) and the lowest in 2000 (2.44 t ha-1). The average yield increase was 114 kg ha-1 per year from 1965 to 1985, and it was 22 kg ha-1 per year from 1986 to 2012. In experiments during the period 1998-2012, when the standard cropping technology (MSY) was applied, the average grain yield was10.46 t ha-1 for hybrids of FAO 300-400, 10.39 t ha-1 for hybrids from FAO 500 and 11.38 for FAO 600-700. There were no significant differences in yield between hybrids from examined FAO groups. According to this, average maize yield includes only 44.2% for FAO 300-400, 44.5% for FAO 500 and 40.6% for FAO 600700 utilized maize genetic potential. The significant improvement of maize production demand the strategic long-term program, where it will be elaborated: merging of land properties, increasing of the areas with irrigation and increasing of the technology level in maize cropping.
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Vala, Jorge y Ana Saint-Maurice. "Representações sociais sobre o descobrimento do Brasil: os actores e a colonização". PSICOLOGIA 17, n.º 2 (4 de febrero de 2014): 385. http://dx.doi.org/10.17575/rpsicol.v17i2.456.
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Neste estudo analisamos a representação social (RS) do descobrimento do Brasil, no quadro da hipótese segundo a qual a evocação dos acontecimentos remotos âncora em princípios identitários. Primeiramente é estudada a representação dos actores da colonização (colonizadores portugueses, índios e escravos africanos), seguidamente esta representação é relacionada com outras dimensões da memória do descobrimento do Brasil. Os dados analisados foram recolhidos na região de Lisboa (N=500) e na cidade do Rio de Janeiro (N=401) através da amostragem por quotas. Os resultados mostram que a identidade nacional e a identidade política, quer em Portugal quer no Brasil, se encontram associadas a representações diferentes sobre os actores. Porém, quando se relacionam as imagens dos colonizadores com outras dimensões da colonização encontramos representações consensuais em Portugal e no Brasil. A valência destas RS é globalmente positiva no caso de Portugal e negativa no caso do Brasil.DOI: http://dx.doi.org/10.17575/rpsicol.v17i2.456
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Zaak Saraiva, Illyushin, Nadja Simone Menezes Nery Oliveira y Camilo Freddy Mendoza Morejon. "Impactos das Políticas de Quarentena da Pandemia Covid-19, Sars-Cov-2, sobre a CT&I Brasileira: prospectando cenários pós-crise epidêmica". Cadernos de Prospecção 13, n.º 2 (16 de abril de 2020): 378. http://dx.doi.org/10.9771/cp.v13i2.36066.
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O fortalecimento das políticas governamentais para a CT&I no Brasil entre 2003 e 2014 – com a criação das Leis de Inovação e do Bem, aumento nos investimentos públicos em CT&I, construção de quase 500 campi de Institutos Federais de Educação, Ciência e Tecnologia, criação de 18 Universidades Federais, e investimentos federais em Educação passando de R$ 24,5 bilhões para R$ 94,2 bilhões – trouxe resultados importantíssimos em termos de produção científica. A ruptura nos investimentos em CT&I a partir da crise econômico-institucional em 2015, contudo, aumentou incertezas quanto aos resultados no longo prazo, forçando instituições a adaptarem-se. A Pandemia Coronavírus Sars-Cov-2, com fechamento de laboratórios e campi universitários e interrupção da atividade econômica em nível mundial, pode alterar ainda mais profundamente os métodos de produção do conhecimento, com substituição de atividades presenciais pela modalidade on-line. Baseando-se em survey com 401 pesquisadores, prospecta-se aqui cenários futuros em Pesquisa Científica no Brasil pós-Covid-19.
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Eberhart, Kevin E. y Paul M. Woodard. "Distribution of residual vegetation associated with large fires in Alberta". Canadian Journal of Forest Research 17, n.º 10 (1 de octubre de 1987): 1207–12. http://dx.doi.org/10.1139/x87-186.
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Fire size and shape, number and size of islands of residual vegetation, amount of edge, and distances to residual vegetation were analyzed for 69 fires that burned in Alberta between 1970 and 1983. These fires ranged in size from 21 to 17 770 ha. Distribution of residual vegetation was compared among five fire size classes. Fires in the smallest size class (20–40 ha) did not contain any islands of unburned vegetation. Percent of area within the fire perimeter that was actually disturbed decreased with increasing fire size. The number of unburned islands per 100 ha was highest for the third and fourth largest fire size classes (201–400 and 401–2000 ha). Median island area per fire, fire shape index, and edge index increased with fire size. Percentages of burned area within 100, 200, 300, 400, and 500 m of residual vegetation decreased with increasing fire size. These results indicate decreased potential for natural reforestation and increased benefits to some wildlife habitats as fire size increases.
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Fadillah, Maria Sarah, Endang Kusdiyantini y Wijanarka Wijanarka. "PRODUKSI PIGMEN DAN ASAM γ-AMINOBUTIRAT (GABA) OLEH Monascus purpureus PADA KONSENTRASI INOKULUM DAN WAKTU INKUBASI YANG BERBEDA". Jurnal Penelitian Saintek 25, n.º 1 (8 de mayo de 2020): 72–83. http://dx.doi.org/10.21831/jps.v25i1.28208.
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Penelitian ini bertujuan untuk mengetahui produksi pigmen dan GABA oleh M. purpureus dengan konsentrasi inokulum dan waktu inkubasi yang berbeda. Fermentasi dilakukan menggunakan metode fermentasi cair dengan konsentrasi inokulum serta waktu inkubasi yang berbeda. Pengukuran pigmen intraselular dilakukan dengan mengekstraksi pelet sel menggunakan etanol 95%. Produksi GABA ditentukan menggunakan metode ninhidrin. Spektrofotometer digunakan untuk mengukur pigmen pada panjang gelombang 500, 470, dan 400 nm, sementara GABA pada panjang gelombang 401 nm. Penelitian menggunakan Rancangan Acak Lengkap (RAL) pola faktorial dengan dua faktor. Hasil penelitian menunjukkan rerata nilai pigmen merah, jingga dan kuning tertinggi pada pigmen ekstraseluler (P<0,05) terjadi pada perlakuan C3, sementara pigmen intraseluler (P<0,05) pada perlakuan C1, dengan perlakuan waktu inkubasi (P<0,05) W14. Interaksi antar kedua perlakuan (C*W) terjadi pada pigmen ekstraseluler merah dan jingga (P<0,05). Produksi GABA tidak berbeda secara signifikan pada pada perlakuan konsentrasi inokulum (P<0,05), tetapi berbeda secara signifikan pada perlakuan waktu inkubasi (P<0,05) dan perlakuan W14 menunjukkan produksi tertinggi (6,1085 mg/ml). Tidak adanya interaksi antardua perlakuan dalam produksi GABA (P>0,05).PRODUCTION OF PIGMENTS AND γ-AMINOBUTYRIC ACID (GABA) BY Monascus purpureusThis study was aimed at examining the production of pigments and GABA by M. purpureus in varied inoculum concentration and incubation time. The fermentation was carried out by submerged fermentation method with inoculum concentration and varied incubation time. Cell pellet was extracted using 95% ethanol for intracellular pigment measurement. GABA production was determined by ninhydrin method. Pigments were measured at 500, 470, and 400 nm wavelength by spectrophotometry, and GABA was measured at 401 nm wavelength. The experimental design was Completely Randomize Design (CRD) factorial with two factors. The higher colour value of extracellular (P<0,05) red, orange and yellow pigments showed at C3 while intracellular (P<0,05) showed at C1 with incubation time at W14. There are some interactions between two factors (C*W) for red and orange extracellular pigments (P<0,05). It was observed that inoculum concentrations have no significant difference (P>0,05) for GABA production. In other hand, there is significant difference for incubation time factors (P<0,05) with the highest production at W14 (6,1085 mg/ml). There is no interaction between two factors for GABA production (P>0,05).
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Odhiambo, Martha Akello, Calleb Olweny Ochia y Erick Otieno Okuto. "Effects of Temperature on the Development and Survival of Cricket Species; Acheta domesticus and Gryllus bimaculatus (Orthoptera: Gryllidae)". East African Journal of Agriculture and Biotechnology 5, n.º 1 (12 de septiembre de 2022): 176–89. http://dx.doi.org/10.37284/eajab.5.1.834.
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Temperature plays an important role in the development and survival of insects. The effects of temperature on the development of two cricket species, Acheta domesticus and Gryllus bimaculatus were determined at six constant temperatures (18, 22, 26, 30, 34 and 380C). Parameters for stage-specific development such as fecundity, weight and fat content, structural body size, sex ratio, development time, and longevity were investigated. Relative humidity, light intensity, and photoperiod were set at 60-90 %, 500 ± 25 Lux, and 12:12 L:D, respectively. The results indicated that the duration of eggs and nymphal stages were significantly influenced by increased temperature. The egg-to-adult developmental period of Acheta domesticus declined from 200.5 days to 66.26 days as the temperature increased from 180C to 30 °C while that for Gryllus bimaculatus decreased from 231.82 to 62.22 days as the temperature increased from 18 to 34°C. The optimum temperature estimated for egg-to-adult ranged from 26˚C to 34˚C. Longevity of both females and males was significantly higher (female: F5, 401 = 7.5, P < 0.001; male: F5, 401 = 6.4, P < 0.001) at 18oC than at other temperatures, with the shortest recorded for Acheta domesticus (female: 20.19 days; male: 26.67 days) and Gryllus bimaculatus (Females: 25.56 days; Males: 27.49 days) at 38oC. Fecundity was highest at 26°C (1360 eggs/female/generation) and lowest at 18°C (101 eggs/female/generation) for Acheta domesticus. For Gryllus bimaculatus, the highest fecundity was recorded at 30°C (1722 eggs/female/generation) and the lowest at 18°C (123 eggs/female/generation). The optimal developmental temperature for crickets was determined to range from 26°C to 34°C. Understanding the impacts of temperature on the development of crickets would provide information on how climate change shapes insect ecologies and enable the development of forecasting models.
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CHA, Hyomin, Syuhei KUROKAWA, Yoji UMEZAKI, Yoji MATSUKAWA y Morihisa HOUGA. "401 Development of a grating disk for a micro rotary encoder : Prototype of the grating disk of 500 μm in diameter using nanoimprint technology". Proceedings of Conference of Kyushu Branch 2013.66 (2013): 113–14. http://dx.doi.org/10.1299/jsmekyushu.2013.66.113.
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Falanghe Carneiro, Paulo César, Jorge Daniel Mikos, Fabiano Bendhack y Sérgio Aparecido Ignácio. "Processamento do jundiá Rhamdia quelen: rendimento de carcaça". Revista Acadêmica: Ciência Animal 2, n.º 3 (15 de julio de 2004): 11. http://dx.doi.org/10.7213/cienciaanimal.v2i3.15082.
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O conhecimento da proporção da matéria-prima que será transformada em produtos finais para comercialização, bem como da quantidade que fará parte do resíduo do processamento permite o planejamento logístico da produção e os cálculos necessários para a avaliação da eficiência produtiva da empresa processadora de pescado. O jundiá Rhamdia quelen é um bagre nativo da América do Sul e que vem sendo estudado há alguns anos por vários grupos de pesquisa latino-americanos, apresentando resultados que atestam seu potencial para a piscicultura. O objetivo do presente trabalho foi avaliar o rendimento do jundiá como matéria-prima para o processamento mínimo em diferentes classes de pesos, a saber: 200 – 300 g, 301 – 400 g, 401 – 500 g, 501 – 600 g, 601 – 700 g, 701 – 800 g. Devido ao crescimento mais acelerado das fêmeas, apenas indivíduos do sexo feminino foram encontrados nas classes de peso acima de 500 g. O rendimento de filé foi maior para os peixes com maior peso médio (728g - 34,7%). A porcentagem de músculo abdominal esteve entre 9,3% e 11,2%. A proporção de vísceras sem as gônadas encontrou-se entre 7,8 e 9,8% e a porcentagem de gônadas das fêmeas com peso médio 572 g representou 11,1% do peso total. A descrição da composição da carcaça dos peixes cultivados tem grande importância sob o aspecto econômico e produtivo, permitindo estimativas de produtividade tanto para o piscicultor quanto para a indústria de processamento.
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Hamdy, Shaheen, Paul Enck, Qasim Aziz, John C. Rothwell, Samet Uengoergil, Anthony Hobson y David G. Thompson. "Spinal and pudendal nerve modulation of human corticoanal motor pathways". American Journal of Physiology-Gastrointestinal and Liver Physiology 274, n.º 2 (1 de febrero de 1998): G419—G423. http://dx.doi.org/10.1152/ajpgi.1998.274.2.g419.
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We investigated the effects of lumbosacral and pudendal nerve stimulation on the corticofugal pathways to the human external anal sphincter. In 11 healthy subjects, anal sphincter electromyographic responses, evoked to transcranial magnetic stimulation of the motor cortex, were recorded 5–500 ms after lumbosacral root or pudendal nerve stimulation. Lumbosacral and pudendal nerve stimulation alone evoked responses with amplitudes of 293 ± 73 and 401 ± 153 μV and latencies of 3.2 ± 0.2 and 2.2 ± 0.2 ms, respectively. Cortical stimulation also evoked responses with amplitudes of 351 ± 104 μV and latencies of 20.9 ± 1.1 ms. When lumbosacral or pudendal nerve stimulation preceded cortical stimulation, the cortically evoked responses were facilitated ( P < 0.01), with the effect appearing greatest at 5–20 ms after both lumbosacral and pudendal excitation and at 50–100 ms after lumbosacral excitation alone. Our results demonstrate that cortical pathways to the external anal sphincter are facilitated by prior lumbosacral and pudendal nerve stimulation, indicating that sensorimotor interactions are important in the central neural control of sphincter function.
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Kurbanov, Yu K. "Distribution of the Notched fin eelpout Lycodes pectoralis (Zoarcidae) in the Northeastern Sea of Okhotsk during the Hydrological Summer". Вопросы ихтиологии 63, n.º 1 (1 de enero de 2023): 31–38. http://dx.doi.org/10.31857/s0042875223010095.
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For the first time, the data are presented on the distribution and size composition of the notched fin eelpout Lycodes pectoralis in the northeastern part of the Sea of Okhotsk during the hydrological summer. Its densest aggregations are located on the continental slope of Kamchatka between 52° and 56° N and in the western part of the TINRO depression, in a local area 56°–57° N. The range of the vertical distribution of L. pectoralis covers depths from 199 to 653 m, and the temperature range in which this species occurs is 0–2.3°С. High frequency of occurrence, average density and biomass of the species are typical for depths of 301–400 and 401–500 m at a temperature of the near-bottom water of 1.0–2.0°С. Based on a critical analysis of the literature data and the fact that L. pectoralis is predominantly confined to the habitat in the waters of the unique intermediate water mass of the Sea of Okhotsk, it is suggested that the species is endemic to the Sea of Okhotsk.
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Mousaviasl, Sajedeh, Sara Sayar, Esmat Radmanesh, Bagher Pahlavanzade, Hani Esmaeilian, Mona Ebrahimzadeh, Raha Tabahfar et al. "The Effect of a Low Dose of Vitamin C in Patients With COVID-19: A Double-Blind Randomized Controlled Trial". Disease and Diagnosis 13, n.º 1 (22 de julio de 2023): 18–25. http://dx.doi.org/10.34172/ddj.500.
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Background: Vitamin C is a micronutrient with anti-inflammatory and free radical scavenging properties that can strengthen the body’s immune system. In this study, it was attempted to assess the clinical efficiency of oral vitamin C in treating COVID-19. Materials and Methods: This double-blind randomized clinical trial was conducted on 401 patients hospitalized in Taleghani hospital, Abadan, over 18 years of age and with confirmed COVID-19 infection, from November 2020 to May 2021. The patients were randomly assigned to intervention groups (201 people, two tablets per day, each containing 500 mg of vitamin C) and the control group (200 people, placebo, containing starch received for five days). Improvements in clinical symptoms, death from baseline to the 28-day follow-up after the intervention, hospital length of stay, and laboratory values of C-reactive protein (CRP) were some of the considered outcome variables. Results: No significant difference was observed between the two groups in terms of the daily improvement of clinical symptoms and the odds of healing from each symptom increased by about 48-50%. The difference in the length of hospital stay between the two groups was close to significant (P=0.051). There was no significant difference in mortality between the two groups (P=0.8). There was no difference between the two groups in the laboratory parameters, except for alkaline phosphatase (P=0.03). Conclusion: Vitamin C had no significant effect on improving patients’ clinical symptoms such as fatigue, fever, cough, and shortness of breath.
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Paramita, Dian, Muhamad Yusa y Lita Darmayanti. "Studi Kuat Geser Lahan Gambut dengan Uji Geolistrik dan Alat Dokenbo". Sainstek (e-Journal) 9, n.º 2 (15 de diciembre de 2021): 116–22. http://dx.doi.org/10.35583/js.v9i2.193.
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Berkembangnya zaman dan meningkatnya jumlah penduduk mengakibatkan penggunaan lahan marginal seperti lahan gambut tidak dapat di hindari. Lahan gambut memiliki karakteristik kepadatan rendah dan konsistensi lunak-sangat lunak. Penentuan kekuatan geser gambut baik di laboratorium maupun di lapangan tidak mudah, alat yang biasa digunakan di lapangan seperti sondir dan SPT memiliki bobot alat berat dan rentang pengukuran yang terlalu besar. Penelitian ini bertujuan mengembangkan metode untuk menentukan kekuatan geser dari nilai resistivitas. Penelitian ini menggunakan alat dokenbo portabel dan uji resistivitas. Pengujian dilakukan di Meranti, daerah yang sebagian besar terdiri dari lahan gambut. Hasil penelitian menunjukkan bahwa rentang nilai resistivitas gambut dominan yang diperoleh adalah 61-70 ohm.m dengan rentang nilai resistivitas 6,7-140 ohm.m. Rentang nilai penetrasi gambut yang dominan adalah 401-500 kN/m2 dengan rentang nilai penetrasi 125-1800 kN/m2. Rentang kohesi gambut yang dominan adalah 0,1-0,5 kN/m2 dengan rentang nilai kohesi 0,1-6,5 kN/m2. Rentang nilai sudut geser dalam gambut dominan adalah 13p-20o dengan rentang nilai sudut geser dalam 13,76o-50,2o. Hubungan dilakukan antara resistivitas dan penetrasi, resistivitas dan kohesi, resistivitas dan sudut geser. Penelitian ini menghasilkan hubungan statistik yang sangat rendah antara resistivitas dan karakteristik mekanik.
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Okomo-Adhiambo, Margaret, Craig Beattie y Anette Rink. "cDNA Microarray Analysis of Host-Pathogen Interactions in a Porcine In Vitro Model for Toxoplasma gondii Infection". Infection and Immunity 74, n.º 7 (julio de 2006): 4254–65. http://dx.doi.org/10.1128/iai.00386-05.
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ABSTRACT Toxoplasma gondii induces the expression of proinflammatory cytokines, reorganizes organelles, scavenges nutrients, and inhibits apoptosis in infected host cells. We used a cDNA microarray of 420 annotated porcine expressed sequence tags to analyze the molecular basis of these changes at eight time points over a 72-hour period in porcine kidney epithelial (PK13) cells infected with T. gondii. A total of 401 genes with Cy3 and Cy5 spot intensities of ≥500 were selected for analysis, of which 263 (65.6%) were induced ≥2-fold (expression ratio, ≥2.0; P ≤ 0.05 [t test]) over at least one time point and 48 (12%) were significantly down-regulated. At least 12 functional categories of genes were modulated (up- or down-regulated) by T. gondii. The majority of induced genes were clustered as transcription, signal transduction, host immune response, nutrient metabolism, and apoptosis related. The expression of selected genes altered by T. gondii was validated by quantitative real-time reverse transcription-PCR. These results suggest that significant changes in gene expression occur in response to T. gondii infection in PK13 cells, facilitating further analysis of host-pathogen interactions in toxoplasmosis in a secondary host.
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Nakamura, Tsuyoshi. "Selected Papers from SCIS & ISIS 2008 – No.1". Journal of Advanced Computational Intelligence and Intelligent Informatics 13, n.º 3 (20 de mayo de 2009): 171. http://dx.doi.org/10.20965/jaciii.2009.p0171.
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Welcome to this special issue of the Journal of Advanced Computational Intelligence and Intelligent Informatics (JACIII). I am pleased to introduce 41 selected papers presented at the 3rd International Conference on Soft Computing and Intelligent Systems (SCIS) and the 7th International Symposium on Advanced Intelligent Systems (ISIS) held on September 17-21, 2008, at Nagoya University in Nagoya, Japan. This conference featured 401 original papers in presentations attended by some 500 participants. SCIS & ISIS is a biennial international joint conference in the field of soft computing and intelligent systems, including branches of research ranging from fuzzy systems, neural networks, and evolutionary computation to multiagent systems, artificial intelligence, and robotics. This current issue presents 20 papers covering most of the conference topics including fuzzy theory, self-organizing maps, robotics, computer vision, and optimization algorithms. I would like to thank the authors and reviewers and SCIS & ISIS 2008 for making this special issue possible. I am also grateful to Prof. Toshio Fukuda, Nagoya University, and Prof. Kaoru Hirota, Tokyo Institute of Technology, the editors-in-chief, and the SCIS & ISIS 2008 conference staff for inviting me to guest-edit this Journal.
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Salem, M. M. I., G. Thompson, S. Chen, A. Beja-Pereira y J. Carvalheira. "Linkage disequilibrium and haplotype block structure in Portuguese Holstein cattle". Czech Journal of Animal Science 63, No. 2 (19 de enero de 2018): 61–69. http://dx.doi.org/10.17221/56/2017-cjas.
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The objectives of this study were to estimate linkage disequilibrium (LD), describe and scan a haplotype block for the presence of genes that may affect milk production traits in Portuguese Holstein cattle. Totally 526 animals were genotyped using the Illumina BovineSNP50 BeadChip, which contained a total of 52 890 single nucleotide polymorphisms (SNPs). The final set of markers remaining after considering quality control standards consisted of 37 031 SNPs located on 29 autosomes. The LD parameters historical recombinations through allelic association (D') and squared correlation coefficient between locus alleles frequencies ( r<sup>2</sup>) were estimated and haplotype block analyses were performed using the Haploview software. The averages of D' and r<sup>2</sup> values were 0.628 and 0.122, respectively. The LD value decreased with increasing physical distance. The D' and r<sup>2</sup> values decreased respectively from 0.815 and 0.283 at the distance of 0–30 kb to 0.578 and 0.090 at the distance of 401–500 kb. The identified total number of blocks was 969 and consisted of 4259 SNPs that covered 159.06 Mb (6.24% of the total genome) on 29 autosomes. Several genes inside the haplotype blocks were detected; CSN1S2 gene in haplotype block 51 on BTA 6, IL6 and B4GALT1 genes in haplotype blocks 6 and 33 on BTA 8, IL1B and ID2 genes in haplotype blocks 19 and 29 on BTA 11, and DGAT1 gene in haplotype block 1 on BTA 14. The extension of LD using BovineSNP50 BeadChip did not exceed 500 kb and its parameters r<sup>2</sup> and D’ were less than 0.2 and 0.70, respectively, after 70–100 kb. Consequently, the 50K BeadChip would have a poor power in genome wide association studies at distances between adjacent markers lower than 70 kb.
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Alam, Misbahuddin Azhar y Zamir Ahmad. "Effect of coded Unani formulation Unim-401 and Soranil with NB-UV-B therapy in a case of chronic palmo-plantar plaque psoriasis- A Case Study." International Journal of AYUSH Case Reports 5, n.º 2 (28 de junio de 2021): 71–77. http://dx.doi.org/10.52482/ijacare.v5i2.207.
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Da’ al-Sadaf (Plaque psoriasis) is the most common form of the psoriasis in which raised, red patches covered with a silvery white buildup of dead skin cells. These patches or plaques most often show up on the scalp, knees, elbows and lower back. Sometimes it is itchy and painful and, may cracked and bleed. Unani oral and topical medicines along with Narrow Band Ultra-Violet (NB-UV-B) therapy is used here for treatment. Unani coded formulation UNIM-401 containing Barg Shahtra (Fumaria parviflora Linn.), Chiraita Talkh (Swertia chirata Buch.), Babchi (Psoralea corylifolia Linn.) and Haleela Siyah (Terminalia chebula Retz.) in the ratio of 5:5:5:2, in a dose of 2 capsules (500 mg each) orally with lukewarm water twice a day in empty stomach for a period of three months are given and Soranil ointment mixed with clarified butter in 1:1 ratio was applied on the affected part and exposed to the NB-UVB light for 10 minutes. Plaques of psoriasis getting shade off after one month of treatment and almost disappeared from the site of lesion after three months. The skin of patient almost become normal. It may be concluded that Unani drugs (oral & topical) along with NB-UVB therapy is beneficial for controlling and treating plaque psoriasis.
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Losno-Prado, Angel Giuseppe y Jose Iannacone. "Caracterización de Microplásticos en Agua y Sedimentos en Los Humedales Los Pantanos De Villa, Chorrillos, Lima, Perú". Boletín de Investigaciones Marinas y Costeras 52, n.º 1 (15 de junio de 2023): 185–94. http://dx.doi.org/10.25268/bimc.invemar.2023.52.1.1155.
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Los humedales Los de Pantanos de Villa (HPV), Chorrillos, Lima, Perú; es un sitio RAMSAR de gran importancia internacional por ser un lugar de descanso en las migraciones de aves. El objetivo fue caracterizar los microplásticos (MP) en agua y sedimentos en la Laguna Mayor de los humedales Los Pantanos de Villa, Chorrillos, Lima, Perú durante septiembre del 2019. Se recolectaron muestras de agua por arrastre vertical con una red Sparenet de 25 µm y de sedimentos de fondo con una draga Van Veen con área de muestreo de 0,025 m2 en tres sectores de la Laguna Mayor del HPV. Se cuantificaron los MP en base al color, forma y tamaño. Se encontraron en el agua 0,94 partículas·L-1, y en los sedimentos 64 partículas·kg-1. En los MP en agua y sedimento el color blanco y celeste/turquesa, la forma poligonal y laminar, y el tamaño de 401 a 500 um fueron los dominantes. Las actividades antrópicas urbanas e industriales, el destino ilegal de desmontes, botaderos y arrojo de basura, tráfico vehicular y peatonal colindante a la Laguna Mayor, y el transporte de MP por viento podrían ser factores que expliquen las diferencias de los MP entre los sectores del HPV.
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Patel, Vipul R., Sagar Shah y David Arend. "Histopathologic Outcomes of Robotic Radical Prostatectomy". Scientific World JOURNAL 6 (2006): 2566–72. http://dx.doi.org/10.1100/tsw.2006.397.
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Robotically assisted laparoscopic radical prostatectomy is a minimally invasive alternative for the treatment of prostate cancer. We report the histopathologic and shortterm PSA outcomes of 500 robotic radical prostatectomies. Five hundred patients underwent robotic radical prostatectomy. The procedure was performed via a six trocar transperitoneal technique. Prostatectomy specimens were analyzed for TNM stage, Gleason’s grade, tumor location, volume, specimen weight, seminal vesicle involvement, and margin status. A positive margin was reported if cancer cells were found at the inked specimen margin. PSA data were collected every 3 months for the first year, then every 6 months for a year, then yearly. The average preoperative PSA was 6.9 (1–90) with Gleason’s score of 5 (2%), 6 (52%), 7 (40%), 8 (4%), and 9 (2%); postoperatively, histopathologic analysis showed Gleason's 6 (44%), 7 (42%), 8 (10%), and 9 (4%); 10, 5, 63, 15, 5, and 2% had pathologic stage T2a, T2b, T2c, T3a, T3b, and T4, respectively. Positive margin rate was 9.4% for the entire series. The positive margin rate per 100 cases was: 13% (1–100), 8% (101–200), 13% (201–300), 5% (301–400), and 8% (401–500). By stage, it was 2, 4, and 2.5% for T2a, T2b, T2c tumors; 23% (T3a), 46% (T3b), and 53% (T4a). For organ-confined disease (T2), the margin rate was 2.5% and it was 31% for nonorgan-confined disease. There were a total of 47 positive margins, 26 (56%) posterolateral, 4 (8.5%) apical, 4 (8.5%) bladder neck, 2 (4%) seminal vesicle, and 11 (23%) multifocal. Ninety-five percent of patients (n = 500) have undetectable PSA (<0.1) at average follow-up of 9.7 months. Recurrence has only been seen with nonorgan-confined tumors. Of those patients with a minimum follow-up of 1 year (average 15.7 months), 95% have undetectable PSA (<0.1). Our initial experience with robotic radical prostatectomy is promising. Histopathologic outcomes are acceptable with a low overall, positive margin rate. Shortterm biochemical recurrence-free survival has also been good. We believe that the precise dissection allowed by the advantages of laparoscopic robotic surgery will translate into excellent long-term oncologic outcomes. At this time, the lack of maturity of the PSA data prevent definitive comparison to the open approach.
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Pardanani, Animesh, Claire N. Harrison, Jorge E. Cortes, Francisco Cervantes, Ruben A. Mesa, Donald Milligan, Tamás Masszi et al. "Results Of a Randomized, Double-Blind, Placebo-Controlled Phase III Study (JAKARTA) Of The JAK2-Selective Inhibitor Fedratinib (SAR302503) In Patients With Myelofibrosis (MF)". Blood 122, n.º 21 (15 de noviembre de 2013): 393. http://dx.doi.org/10.1182/blood.v122.21.393.393.
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Abstract Background Fedratinib (SAR302503) is a JAK2-selective inhibitor that has provided clinically meaningful reductions in MF-associated splenomegaly and symptoms in Phase I and II studies (J Clin Oncol 2011;29:789. Haematologica 2013;98:S1113). Here, we present efficacy and safety data from the Phase III JAKARTA study of fedratinib versus placebo in patients with MF (NCT01437787). Methods In this international double-blind, placebo-controlled, 3-arm study, patients aged ≥18 years with IPSS intermediate-2 or high-risk MF, platelet count ≥50 × 109/L, and splenomegaly were randomized (1:1:1) to receive placebo or fedratinib 400 mg or 500 mg, orally, once daily, in consecutive 4-week cycles. Patients who received placebo were eligible to cross-over to fedratinib (randomized 1:1 to 400 mg or 500 mg) following 6 cycles of treatment, or prior to Cycle 6 if the patient had disease progression. The primary endpoint was spleen response rate (RR) (≥35% reduction in spleen volume from baseline measured by MRI or CT at Week 24, and confirmed 4 weeks later). Secondary endpoints included symptom RR (≥50% reduction in total symptom score from baseline at Week 24, measured through a daily electronic eDiary using the modified Myelofibrosis Symptom Assessment Form [Cancer 2011;117:4869. Blood 2011;118:401]), and safety of fedratinib. Results A total of 289 patients were randomized: median age 65 years; 59% male; 63% primary MF; 48% high-risk MF; 67% JAK2V617F positive; 16% platelet count <100 × 109/L; median baseline spleen volume 2568 mL (range 316–8244); median baseline total symptom score 14.7 (0–57). Median (range) exposures for placebo, 400 mg and 500 mg groups were 24 (2–34), 30 (1–55) and 28 (1–60) weeks, respectively. Spleen RRs at Week 24 (placebo 1%; 400 mg 47%; 500 mg 49%), and confirmed at Week 28 (placebo 1%; 400 mg 36%; 500 mg 40%), were significantly (p<0.0001) higher in both fedratinib groups compared with placebo (Table). Nineteen patients had a spleen response at Week 24 not confirmed 4 weeks later (spleen reduction 25–35% [n=10]; image not available/evaluable [n=8]; image taken outside time window [n=1]). Spleen RRs by baseline platelet level are shown in the table. Patients treated with fedratinib had significantly (p<0.0001) greater improvements in MF symptoms compared with placebo (Table). The most common all grade non-hematologic treatment-emergent adverse event (TEAE) was diarrhea (16%, 66% and 56% of patients in the placebo, 400 mg and 500 mg groups, respectively). Grade 3/4 diarrhea was reported in 5% of patients in both the 400 mg and 500 mg dose groups. The most common hematologic TEAE was anemia (any grade 91%, 99% and 98%; Grade 3/4 25%, 43% and 60% in the placebo, 400 mg and 500 mg groups, respectively). Rates of Grade 3/4 thrombocytopenia were 9% (placebo), 17% (400 mg), and 27% (500 mg). Incidences of Grade 3/4 liver function tests (placebo/400 mg/500 mg) were: bilirubin, 2%/2%/1%; ALT, 0%/3%/3%; and AST, 1%/2%/2%. Overall treatment discontinuation rates up to 24 weeks of treatment were 25% (placebo), 22% (400 mg) and 32% (500 mg). Twenty-five patients died during the study (10, 5 and 10 in the placebo, 400 mg and 500 mg groups, respectively); the most common causes of death: disease progression (placebo [n=5]; 400 mg [n=3]; 500 mg [n=4]) and adverse events (placebo [n=4]; 400 mg [n=1]; 500 mg [n=4]). Conclusions In this Phase III, randomized, placebo-controlled, 3-arm study of 289 MF patients, treatment with fedratinib 400 mg or 500 mg once-daily demonstrated clinically meaningful and statistically significant reductions in splenic volume and MF-associated symptom burden versus placebo. Fedratinib had an acceptable safety profile, with the adverse events reported consistent with those observed in previous studies. This study was sponsored by Sanofi. Disclosures: Pardanani: Sanofi, Bristol Myers Squibb, PharmaMar and JW Pharma: Clinical trial support Other. Harrison:Novartis: Research Funding; Novartis, Sanofi, YM Bioscience, Celgene, SBio, Gilead: Honoraria; Novartis, Sanofi, Shire: Speakers Bureau; Novartis, Sanofi, YM Bioscience, SBio, Gilead: Membership on an entity’s Board of Directors or advisory committees. Cortes:Incyte, Sanofi: Consultancy; Incyte, Sanofi: Research Funding. Cervantes:Novartis: Speakers Bureau; Novartis and Sanofi: Membership on an entity’s Board of Directors or advisory committees. Mesa:Incyte, Genentech, Lilly, MS Pharma, Gilead: Research Funding. Jourdan:Sanofi: Honoraria. Vannucchi:Novartis: Membership on an entity’s Board of Directors or advisory committees. Drummond:Sanofi, Novartis, Celgene: Honoraria; TargeGen, Novartis: Speakers Bureau; Sanofi, Novartis, Celgene: Consultancy. Passamonti:Novartis, Celgene, Incyte, Sanofi, Roche: Honoraria. Neumann:Sanofi: Employment. Gao:Sanofi: Employment.
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Dinesh Ram, S., Dharmendra Kumar Shukla y Aman Gupta. "Fatigue strength of copper and mild steel single lap joints bonded with epoxy-alumina nanocomposite adhesive". IOP Conference Series: Materials Science and Engineering 1248, n.º 1 (1 de julio de 2022): 012091. http://dx.doi.org/10.1088/1757-899x/1248/1/012091.
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Abstract An In-situ polymerization technique was used to create an epoxy nano-alumina composite adhesive. Ultrasonication was used to achieve the distribution of nano-alumina particles in an epoxy matrix containing weight percentage 0.5,1,1.5 and 2% nanoparticles. Single lap joints with adherents of Copper-Copper (CC), Mild Steel-Mild Steel (MM) and Copper-Mild Steel (CM) were prepared following ASTM D1002 standards. Lap shear strength tests in tension of bonded joint samples (CC, MM, and CM) were conducted on UTM at 1.27 mm/min cross head travel rate. The fatigue strength of bonded specimens was tested at a stress ratio of R 0.1 and a frequency 5HZ by following ASTM D3166 standards. Stress amplitudes of fatigue test were taken at 70%, 65%, 60% and 55% of shear strength of corresponding single lap joints. Six samples were tested to calculate the average number of cycles to failure. For each combination of joints shear strength and fatigue life were increased with an increase in wt.% but maximum increment was obtained at 1.5 wt.% of nanoparticles addition. An increment of 40% for CC joints, 66% for MM joints and 47% for CM joints was obtained in nanocomposite’s shear static strength containing 1.5 wt.% nanoparticles over neat epoxy joints. Increment in fatigue life of CC, MM, and CM joints at 1.5 wt.% of spherical nanoparticle inclusions was 401%, 500%, and 409% respectively.
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Saternus, Mariola. "The Influence of the Impeller Shape on Hydrogen Removal from Liquid Aluminium - Physical Model". Materials Science Forum 706-709 (enero de 2012): 1515–20. http://dx.doi.org/10.4028/www.scientific.net/msf.706-709.1515.
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Today the barbotage process is commonly used for refining aluminium and its alloys. There are many refining reactors available all over the world. The refining gas can be introduced to the liquid metal by nozzles, ceramic porous plugs and rotary impellers. The last ones become the most popular. The shape of impellers is different and influences the level of gas dispersion in the liquid metal. Physical modelling is quite often used for modelling the aluminium barbotage process. In this way it is possible to observe the phenomena that take place in the whole process. Results obtained from this kind of research can be representative and transformed to real conditions if the test stand is built according to the theory of similarity. The test stand was built for modelling the refining process in the URO-200 reactor. Three different shapes of impellers were tested. The processing parameters like the flow rate of refining gas and the impeller rotary speed changed in the range from 5 to 15 dm3/min and from 0 to 500 rpm respectively. Additionally the research of oxygen removal from water was carried out as an analogy of hydrogen removal from liquid aluminium. The level of oxygen was measured by means of oxygen meter Elmetron CO-401. The obtained results were discussed and graphically presented.
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Zmărăndache, Diana Daniela Daciana, Mihaela Tănase, Ioana Andreea Stanciu, Cristian Teodorescu, Carmen Larisa Nicolae, Crenguța Albu y Ioana Daniela Tărlungeanu. "Clinico-statistical study regarding the reasons for dental emergency presentations in a pedodontics clinic". Romanian Journal of Stomatology 67, n.º 4 (31 de diciembre de 2021): 254–59. http://dx.doi.org/10.37897/rjs.2021.4.10.
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Aim. To evaluate the reasons for seeking dental care for children and teenagers attending an emergency clinic and the proportion of single visits treatments. Material and methods. A retrospective study was made on 500 children and teenagers (252 girls), mean age 13.91±2.3 years, who attended the emergency office from the Paedodontics Department of "Carol Davila" University of Medicine and Pharmacy, Bucharest, during 2017-2019. Information regarding age/gender/diagnosis and treatment were analyzed. Statistical analysis included descriptive statistics and Pearson's Chi-square test with the significance level set as p < 0.05. Results. For 401 children (80.2%), pain was the main reason for the presentation in an emergency visit. 11% came for a specialist consultation and the others 8.8% because of a dental trauma. Nearly 79% of the visits were due to caries: 39% simple decays and 40% complicated caries. Of the decayed teeth, 62.8% were on the posterior teeth and 37.2% on the anterior permanent teeth. Only 15.4% needed one single visit treatment, the others needed a complex pulp therapy. Conclusions. Pain caused by dental decay was the most frequent chief complaint. A lot of children were brought to the dentist with complaints that had started long time before, for which over-the-counter medications had been used. Most children had complicated caries which requires multiple treatment sessions.
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Izumi, Hideyuki “E” y Yuri Hosokawa. "Athletic Training Services in Japan: A Comparison of the United States and Japan Based on Educational Background". Athletic Training Education Journal 14, n.º 4 (1 de octubre de 2019): 305–14. http://dx.doi.org/10.4085/1404305.
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Context Each country has a unique history in the development of its athletic training professionals and education and credentialing systems. In Japan, the majority of athletic trainers hold a domestic credential (JSPO-AT) obtained from the Japan Sport Association (JSPO) or a US-based credential from the Board of Certification (BOC-AT). Objective To determine whether differences in demographic, professional, and educational characteristics exist between Japanese BOC-ATs and JSPO-ATs who currently practice athletic training services in Japan. Design Cross-sectional study. Setting Online survey. Patients or Other Participants Eight hundred twenty-nine Japanese athletic trainers in Japan (BOC-AT, n = 64; JSPO-AT, n = 765). Main Outcome Measure(s) Pearson's χ2 test and Fisher's exact test were used to determine differences in demographic, professional, and educational characteristics between BOC-ATs and JSPO-ATs. Results The proportion of female respondents was greater for BOC-ATs (29.7%) than for JSPO-ATs (18.7%; χ2 [1] = 4.5, P = .03). A greater proportion of BOC-ATs reported having master's degrees or higher (χ2 [3] = 81.6, P < .01). The percentage of respondents with at least 1 therapist or medical practitioner license in Japan was greater for JSPO-ATs (73.1%) than for BOC-ATs (20.3%; P < .01). The percentage of respondents with at least 1 credential in exercise, nutrition, or teaching was greater for BOC-ATs (62.5%) than for JSPO-ATs (45.2%; P < .01). A large difference was observed in the proportion of individuals who identified as therapists (JSPO-ATs = 29.8%, BOC-ATs = 6.3%; χ2 [5] = 18.9, P < .01). The median income for BOC-ATs was 401–600 million yen (US$36 500–$54 500), whereas the median income for JSPO-ATs was 0–200 million yen (US$0–$18 200). Conclusions BOC-ATs in Japan were more established than JSPO-ATs as athletic training professionals with higher educational backgrounds, while more JSPO-ATs tended to be therapists. Findings from the current study may serve as benchmark data for the athletic training profession and service characteristics in Japan.
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Yulia, Dwi, Rikarni Rikarni y Ellyza Nasrul. "Efek Pemberian Kalsium dan Berjemur Terhadap Kadar D-Dimer pada Penderita Diabetes Mellitus Tipe 2 di Sumatera Barat". Health and Medical Journal 5, n.º 1 (20 de diciembre de 2022): 31–37. http://dx.doi.org/10.33854/heme.v5i1.1081.
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Tujuan: Penelitian ini bertujuan untuk menganalisis pengaruh berjemur dan pemberian tablet kalsium terhadap kadar D-dimer pada penderita Diabetes Mellitus tipe 2 yang terkontrol. Berjemur adalah memanfaatkan sarana alam sinar matahari yang tersedia sesuai standar operasional waktu yang terukur, dan pemberian tablet Kalsium 500 mg tiap hari dapat menurunkan kadar D-dimer yang berisiko terjadinya obstruksi pada pembuluh darah dan berpotensi munculnya kerusakan endotel pembuluh darah. Dengan menggunakan faktor alam terapi berjemur dapat membantu memperbaiki penyakit dan merencanakan terapi. Metode: Rancangan penelitian ini adalah studi kohort prospektif dengan jumlah sampel sebanyak 20 data pasien yang terdiagnosis sebagai penderita Diabetes Mellitus tipe 2 di RSUD Prof Dr. Ali Hanafiah SM Batusangkar selama periode 2019-2020. Data yang dianalisis adalah kadar D-dimer sebelum dilakukan perlakuan berjemur dengan waktu yang terukur, serta pemberian tablet kalsium sebagai suplemen yang dapat mempengaruhi proses koagulasi dalam pembuluh darah. Kasus Diabetes mellitus tipe 2 dipilih kasus Diabetes yang terkontrol dengan pemeriksaan HBA1c dibawah 6.5%. Selajutnya, setelah dilakukan proses berjemur dan pemberian suplemen Kalsium selama 1 bulan, dilakukan kembali pemeriksaan D-dimer. Analisis data penelitian dilakukan pada derajat kepercayaan 95% CI (α=0.05), apabila hasil yang didapatkan diperoleh nilai p<0.05 maka terdapat hubungan yang bermakna. Pengolahan dan analisis data dilakukan dengan program SPSS 25. Hasil: Dua puluh pasien Diabetes Mellitus tipe 2 dilakukan pemerisaan D-dimer didapatkan rerata d-dimer 582 ±806 ng/mL. Selanjutnya dilakukan perlakuan berjemur sesuai protokol berjemur selama 30 hari dan pemberian suplemen tablet kalsium 500 mg, setelah itu dilakukan kembali pemeriksaan kadar D-dimer, didapatkan rerata d-dimer 401 ±390 ng/mL Terdapat kecenderungan penurunan kadar D-dimer setelah perlakuan berjemur dan pemberian tablet kalsium dengan hubungan yang bermakna antara kadar D-dimer sebelum dan sesudah perlakuan berjemur dan pemberian tablet kalsium pada penderita Diabetes Mellitus tipe 2. Simpulan: Pada penelitian ini ditemukan penurunan kadar D-dimer pada pasien Diabetes Mellitus tipe 2 setelah dilakukan perlakuan berjemur dan pemberian tablet kalsium. Namun, tidak diketahui apakah peran kombinasi berjemur dengan pemberian tablet kalsium atau ada peran dari masing masing variabel.
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Elit, Lorraine, Florence Manjuh, Lillian Kila, Beatrice Suika, Manuela Sinou, Eliane Bozy, Ethel Vernyuy, Amandine Fokou, Edith Welty y Thomas Welty. "Mother–Child Approach to Cervical Cancer Prevention in a Low Resource Setting: The Cameroon Baptist Convention Health Services Story". Current Oncology 31, n.º 6 (3 de junio de 2024): 3227–38. http://dx.doi.org/10.3390/curroncol31060244.
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Introduction: The rates of cervical cancer screening in Cameroon are unknown and HPV vaccination coverage for age-appropriate youths is reported at 5%. Objectives: To implement the mother–child approach to cervical cancer prevention (cervical screening by HPV testing for mothers and HPV vaccination for daughters) in Meskine, Far North, Cameroon. Methods: After the sensitization of the Meskine–Maroua region using education and a press-release by the Minister of Public Health, a 5-day mother–child campaign took place at Meskine Baptist Hospital. The Ampfire HPV Testing was free for 500 women and vaccination was free for age-appropriate children through the EPI program. Nurses trained in cervical cancer education conducted group teaching sessions prior to having each woman retrieve a personal sample. Self-collected samples were analyzed for HPV the same day. All women with positive tests were assessed using VIA–VILI and treated as appropriate for precancers. Results: 505 women were screened, and 92 children vaccinated (34 boys and 58 girls). Of those screened, 401 (79.4%) were aged 30–49 years old; 415 (82%) married; 348 (69%) no education. Of the HPV positive cases (101): 9 (5.9%) were HPV 16, 11 (10.1%) HPV 18, 74 (73%) HPV of 13 other types. Those who were both HPV and VIA–VILI positive were treated by thermal ablation (63%) or LEEP (25%). Conclusion: The mother–child approach is an excellent method to maximize primary and secondary prevention against cervical cancer.
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Ahmet Hakan Yaz y Necati Cemaloğlu. "Tendencies of the doctoral theses on work engagement in Türkiye: a content analysis study". Eximia 13 (30 de mayo de 2024): 510–25. http://dx.doi.org/10.47577/eximia.v13i1.481.
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The purpose of this study is to conduct a content analysis of the doctoral theses on work engagement published by The Council of Higher Education (CoHE) National Thesis Center in Türkiye. This study is a qualitative method in which descriptive survey model is applied and the theses were selected via purposive sampling technique. Through this process 45 theses published between 2020 and 2024 within a period of five years were determined. “Theses Classification Form” developed by the researchers was used as a data collection tool. Data was analysed by content analysis technique. According to the form, the variables for the theses were classified in terms of; the published year, subject areas, universities, university types, language, method, data collection tools, sampling and sampling size. The findings were visualized via tables and graphs with percentages and frequencies. As a result of the analysis, it was found that work engagement has been a popular topic for PhD. studies for the past five years. Besides, surveys were performed in order to collect the data with quantitative method. Furthermore, the theses were significantly conducted in business administration area. In addition, the theses were mostly published in Turkish language in a majority of public universities. There is, however, relatively balanced distribution among universities conducting research on work engagement. Also, a majority of the theses were conducted on sector employees with a sampling size of 401 - 500 participants. Finally, some recommendations were made to be followed for further studies.
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Wong, D., R. Kantschuster, L. Matini, D. Simadibrata, M. Lepetyukh, J. Wilson, O. Brain et al. "P298 Patient-reported outcomes: the ICHOM standard set for IBD in real-life practice helps quantify deficits in current care". Journal of Crohn's and Colitis 14, Supplement_1 (enero de 2020): S302. http://dx.doi.org/10.1093/ecco-jcc/jjz203.427.
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Abstract Background Ulcerative colitis (UC) or Crohn’s disease (CD) are associated with symptoms that lead to reduced quality of life and increased healthcare utilisation. The patient reported outcome (PRO) tools are key to documenting outcomes that matter most to patients and are increasingly important to commissioners of health care seeking value. We report the first series of the ICHOM Standard Set for inflammatory bowel disease (IBD). Methods Patients treated for UC or CD in our tertiary referral centre are offered enrolment into the TrueColours IBD web-based PRO collection programme. This functions through email prompts, directly linked to validated questionnaires. Prompts for symptoms (daily SCCAI for UC and HBI for CD); quality of life (fortnightly IBD-Control); and other outcomes (baseline and 3 monthly ICHOM Standard Set), including data on steroid use, hospital admission and other measures through internationally agreed criteria. Results The first 500 consecutive patients enrolled (401 UC, 99 CD) were studied. 274 (55%) were female, mean age 40 years (sd 15), and mean BMI 26 (sd 6). 22/500 (5%) were current smokers. Baseline medications at the time of registration were no therapy 6%, topical therapies 21%, 5ASA 49%, thiopurines 24%, methotrexate 6%, budesonide 3%, prednisolone 10%, advanced therapies 37%. (adalimumab 13%, golimumab <1%, infliximab 9%, tofacitinib 1%, ustekinumab 1%, vedolizumab 16%). In the previous 12 months, prednisolone use was reported by 148 (37%) patients with UC vs. 25 (25%) patients with CD, p = 0.02: 107 (21%) for <3 months and 66 (13%) for >3 months. 61 (12%) patients reported requiring an IBD-related intervention (11% UC vs. 17% CD) and 25 (5%) reported an unplanned hospital admission (4% UC vs. 8% CD). Eighty-one (16%) participants had required at least one hospital admission in the preceding year, exceeded by 101 (20%) requiring at least one emergency department presentation in the same period. There were high rates of fatigue (53%) and mood disturbance (26%). Eighty-two (16%) felt they needed a treatment change, and 136 (27%) felt their current treatment was not useful for their IBD. Conclusion Outcomes reported by patients illustrate the scale of the therapeutic deficit in current care. The ICHOM Standard Set acts as a benchmark for comparing outcomes between institutions.
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Kireev, Ivan M., Mikhail V. Danilov, Zinaida M. Koval’ y Filipp A. Zimin. "Technological process of field crops spraying with slotted sprayers". Tractors and Agricultural Machinery 89, n.º 6 (3 de abril de 2023): 395–401. http://dx.doi.org/10.17816/0321-4443-115022.
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BACKGROUND: The subject of the study is the technological process of spraying field crops with slotted sprayers and the indicators dispersion.
AIMS: Improving the technological process of spraying plants with the use of pneumo-hydraulic slotted sprayers.
METHODS: Special equipment was used for photographing films of the liquid being sprayed under various operating modes of slotted sprayers with the possibility of calculating the size of the droplets. Fulfillment of the requirements for the number of drops/cm2 at the treated object, overlapping the liquid spray jets ensures uniform distribution of drops over the spraying width. Therefore, it was sufficient to have information about the fragmentation of the thickness of the liquid film along the axis of the nozzle spray liquid into drops and obtaining their quantity per unit time depending on the flow rate of the working fluid.
Newness of the research lies in determining the effective operation of slotted sprayers as part of the spraying device.
RESULTS: With the use of the special equipment, it is possible to fulfill agrotechnical requirements for droplet sizes. When using herbicides for foliar post-emergence treatment with a systemic pesticide, the limits of MMD range are from 226 m to 400 m. Soil herbicide treatment with a systemic pesticide requires an increased droplet MMD range of 401 m to 500 m and 500 m. The number of drops/cm2 when using fungicides is limited from 50 to 70, insecticides from 20 to 30, and herbicides from 20 to 40.
CONCLUSIONS: The applied technology makes it possible to reduce the consumption of preparations and working fluid with high work performance and resource saving. The above research results can be used as the basis for determining the effective technology of a boom sprayer with slotted liquid sprayers. Fulfillment of the requirements for the number of drops/cm2 at the treatment facility overlapping liquid spray torches ensures a uniform distribution of drops over the spraying width. Therefore, it suffices to know about the division of the thickness of the liquid film along the axis of the liquid spray jet into drops and to obtain their number per unit time.
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Reade, Nathan Z., Julian M. Biddle, Jason W. Ricketts y Jeffrey M. Amato. "Zircon (U-Th)/He Thermochronologic Constraints on the Long-Term Thermal Evolution of Southern New Mexico and Western Texas". Lithosphere 2020, n.º 1 (1 de septiembre de 2020): 1–25. http://dx.doi.org/10.2113/2020/8881315.
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Abstract Zircon (U-Th)/He (ZHe) dates are presented from eight samples (n=55) collected from three ranges including the Carrizo and Franklin Mountains in western Texas and the Cookes Range in southern New Mexico. ZHe dates from Proterozoic crystalline rocks range from 6 to 731 Ma in the Carrizo Mountains, 19 to 401 Ma in the Franklin Mountains, and 63 to 446 Ma in the Cookes Range, and there is a negative correlation with eU values. These locations have experienced a complex tectonic history involving multiple periods of uplift and reburial, and we use a combination of forward and inverse modeling approaches to constrain plausible thermal histories. Our final inverse models span hundreds of millions of years and multiple tectonic events and lead to the following conclusions: (1) Proterozoic exhumation occurred from 800 to 500 Ma, coinciding with the break-up of Rodinia; (2) elevated temperatures at approximately 100 Ma occurred during final development of the Bisbee basin and are a likely result of elevated heat flow in the upper crust during continental rifting; (3) a pulse of cooling associated with Laramide shortening is observed from 70 to 45 Ma in the Cooks Range and 80 to 50 Ma in the Franklin Mountains, whereas the Carrizo Mountains were largely unaffected by this event; and (4) final cooling to near-surface temperatures began 30–25 Ma at all three locations and was likely a result of Rio Grande rift extension. These data help to bridge the gap between higher and lower temperature isotopic systems to constrain complex thermal histories in tectonically mature regions.
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Mussi, Fernanda Carneiro, Caren Lorena Menezes Freitas, Tássia Teles Santana de Macêdo, Eliane Barbosa de Souza y Alana De Souza Reis Carneiro. "Reasons for food choices in nursing university students". Journal of Nursing Education and Practice 11, n.º 2 (25 de octubre de 2020): 50. http://dx.doi.org/10.5430/jnep.v11n2p50.
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Background and objective: Food choice is a complex process that involves sensory and non-sensory characteristics, therefore, sociocultural, and psychological factors. The purpose of this study was to describe the reasons for food choices of nursing university students.Methods: Cross-sectional study with 286 university students of the nursing course at a public university in Salvador/BA. Data were obtained by applying sociodemographic and academic life characterization instruments. The reasons for food choices were evaluated by the Food Choice Questionnaire (FCQ). The data were analyzed in percentages and the reasons for food choices by calculating the unweighted mean of each factor.Results: There was a predominance of females (90.2%), unmarried with partners (90.9%), black race/color (87.8%). and the mean age was 23.4 years old (sd = 4.4). The majority of the students had semester load between 401 and 500 hours (58.8%) and attended university in two or more shifts (80.4%). Among the nine dimensions of the instrument, Sensory Appeal (x̄ = 3.35), Price (x̄ = 3.27) and Health (x̄ = 3.18) were the three most important for food choice. The familiarity and ethical concern factors were the least considered. Considering the FCQ items, the students chose the foods first because they were tasty (x̄ = 3.52), healthy (x̄ = 3.47) and of good price (x̄ = 3.40).Conclusions: For the students, the sensory appeal was the main reason for choosing food, being more relevant than price and health. Thus, there is need to consider the supply of healthy, attractive, and affordable foods in the university environment.
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Shah, Jharna N., Santosh B. Murthy, Rachel Dlugash, Nichol McBee, Issam Awad, Daniel F. Hanley y Wendy C. Ziai. "Venous Thromboembolism After Intraventricular Hemorrhage: Results From the CLEAR III Trial". Neurosurgery 84, n.º 3 (21 de mayo de 2018): 709–16. http://dx.doi.org/10.1093/neuros/nyy189.
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Abstract BACKGROUND Venous thromboembolism (VTE) after intracerebral hemorrhage is well studied, but data on patients with spontaneous intraventricular hemorrhage (IVH) are limited. OBJECTIVE To study the factors associated with VTE, association between VTE and clinical outcomes in IVH, and safety of VTE chemoprophylaxis in IVH treated with intraventricular catheters and thrombolysis. METHODS Retrospective cohort study of patients enrolled in the CLEAR III trial, a multicenter, randomized trial comparing external ventricular drainage, with administration of intraventricular alteplase vs placebo, for obstructive IVH. Predictor variable was incident VTE in the first 30 d. Outcome measures were factors associated with VTE, and death/severe disability (modified Rankin Score 4-6) at 6 mo. RESULTS Of the 500 patients with IVH, VTE occurred in 59 patients (11.8%) within the first 30 d. VTE chemoprophylaxis was initiated in 412 (82.4%) patients, but before VTE diagnosis in only 401 (80.2%) at median of 4 d (interquartile range, 1-8) from IVH onset, and was not associated with intracranial bleeding or catheter tract hemorrhage. In the multivariate logistic regression analysis, infection within 30 d (odds ratio, 1.80; confidence interval, 1.03-3.17) was significantly associated with higher odds of VTE occurrence. Starting VTE chemoprophylaxis after 72 h was additionally associated with VTE occurrence after the first week. CONCLUSION Infection and delay in timely initiation of VTE chemoprophylaxis were associated with VTE occurrence. VTE chemoprophylaxis in IVH appears safe and should not be delayed beyond standard care policies for ICH including when intraventricular catheter placement and thrombolytic therapy are performed.