Tesis sobre el tema "3D soft tissue prediction"
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OLIVETTI, ELENA CARLOTTA. "When 3D geometrical face analysis meets maxillofacial surgery-a methodology for patients affected by dental malocclusion". Doctoral thesis, Politecnico di Torino, 2022. http://hdl.handle.net/11583/2963954.
Texto completoLiang, Haidong. "Facial soft tissue 3D modelling". Thesis, University of Surrey, 1999. http://epubs.surrey.ac.uk/842802/.
Texto completoHajeer, Mohammad Younis. "3D soft-tissue, 2D hard-tissue and psychosocial changes following orthognathic surgery". Thesis, University of Glasgow, 2003. http://theses.gla.ac.uk/3126/.
Texto completoGolec, Karolina. "Hybrid 3D Mass Spring System for Soft Tissue Simulation". Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1004/document.
Texto completoThe need for simulations of soft tissues, like internal organs, arises with the progress of the scientific and medical environments. The goal of my PhD is to develop a novel generic topological and physical model to simulate human organs. Such a model shall be easy to use, perform the simulations in the real time and which accuracy will allow usage for the medical purposes.This thesis explores novel simulation methods and improvement approaches for modeling deformable bodies. The methods aim at fast and robust simulations with physically accurate results. The main interest lies in simulating elastic soft tissues at small and large strains for medical purposes. We show however, that in the existing methods the accuracyto freely simulate deformable bodies and the real-time performance do not go hand in hand. Additionally, to reach the goal of simulating fast, many of the approaches move the necessary calculations to pre-computational part of the simulation, which results in inability to perform topological operations like cutting or refining.The framework used for simulations in this thesis is designed to simulate materials using Mass Spring Systems (MSS) with particular input parameters. Using Mass-Spring System, which is known for its simplicity and ability to perform fast simulations, we present several physically-based improvements to control global features of MSS which play the key role in simulation of real bodies
DI, LISA DONATELLA. "Biopolymeric microbeads as a 3D scaffold for soft tissue engineering". Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/1005298.
Texto completoWeibin, Lin. "Improvement of 3D printing quality for fabricating soft scaffolds". ASME, 2014. http://hdl.handle.net/1993/30281.
Texto completoScholze, Mario, Aqeeda Singh, Pamela F. Lozano, Benjamin Ondruschka, Maziar Ramezani, Michael Werner y Niels Hammer. "Utilization of 3D printing technology to facilitate and standardize soft tissue testing". Nature Publishing Group, 2018. https://monarch.qucosa.de/id/qucosa%3A31244.
Texto completoZardawi, Faraedon M. M. "Characterisation of implant supported soft tissue prostheses produced with 3D colour printing technology". Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/3299/.
Texto completoRoos, Bryan K. "A comparison of soft tissue prediction tracings using the Andrews and Ricketts diagnostic techniques". Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2819.
Texto completoTitle from document title page. Document formatted into pages; contains ix, 77 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 58-61).
Jelier, Pamela. "The integration of soft tissue data into a 3D model of the human head". Thesis, University of Surrey, 1995. http://epubs.surrey.ac.uk/844340/.
Texto completoSingh, Dharaminder. "2D patterning and 3D printing of novel PGSm for peripheral nerve repair and soft tissue engineering". Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/19943/.
Texto completoBabb, Lisa. "Influence of facial profile on social perceptions: a 3D video imaging study". VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/2979.
Texto completoWade, Mary E. "Engineering of Elastomeric Biomaterials and Biomimicry of Extracellular Matrix for Soft Tissue Regeneration". University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1478000902817738.
Texto completoLee, Mark K. "The study and analysis of soft tissue mechanics, application of a 3D dynamic computed tomography scanner for vascular imaging". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0010/NQ40270.pdf.
Texto completoAsa'Ad, F. "ALVEOLAR BONE AUGMENTATION PRIOR TO DENTAL IMPLANT PLACEMENT: VOLUME ANALYSIS & APPLICATIONS OF PRE-AUGMENTATION SOFT TISSUE EXPANSION (STE) AND REGENERATION WITH 3D PRINTED SCAFFOLDS". Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/534216.
Texto completo1.1. ABSTRACT OBJECTIVES: The aim of this review was to explore the development of soft tissue expanders, their different types and their potential applications prior to bone augmentation and implant placement. MATERIALS & METHODS: A review of pertinent literature was performed using PubMed to comprehend the dynamics of soft tissue expanders and determine the current position of their pre- augmentation applications. RESULTS: There is promising, albeit preliminary information regarding the benefits of pre- augmentation soft tissue expansion (STE). Findings cannot be generalized due to relatively small sample size of the scarce clinical studies available in literature. CONCLUSIONS: Further clinical trials with larger sample sizes and long-term follow-up are needed before soft tissue expanders can be confidently applied in everyday clinical practice. 2.1. ABSTRACT OBJECTIVES: To investigate the clinical outcomes, complications and volume gain of pre-augmentation soft tissue expansion (STE). MATERIALS & METHODS: Tissue expanders were implanted in seven patients requiring vertical and/or horizontal bone augmentation. Guided bone regeneration (GBR) was carried out either after 20, 40 or 60 days of STE. Vertical and horizontal bone gains were analyzed with cone beam computed tomography (CBCT) scans. Optic scanning and superimposition of cast models fabricated from pre- and post- augmentation alginate impressions were used for volumetric analysis. RESULTS: Seven sites in seven patients were treated with STE. Perforation occurred in two sites; early failure due to the tightness of the prepared pouch, and late failure due to minor cracks of the silicon shell covering the expander as a result of handling of the expander body with a dental tweezer. Post-expansion, primary wound closure was easily achieved at augmentation without any subsequent graft expositions. Six months post-augmentation, CBCT analysis revealed high vertical bone gain (mean = 7.3 ± 1.2 mm). Mean of horizontal bone gain was 5.5 ± 2.9 mm. Volumetric analysis of three successful expansion cases revealed a mean volume increase of 483.8 ± 251.7 mm3. Soft tissue volume increase corresponded only to the 0.24 ml cylinder expander (volume increase = 259.4 mm3), while this increase was almost half of the final expander volume for the 0.7 and 1.3 ml cylinder expanders (436.1 mm3 & 755.9 mm3 respectively). Volumetric analysis of the late expansion failure reflected soft tissue shrinkage, which might suggest that STE affects tissues by tension and does not cause real volume gain. All dental implants were osseointegrated in the patients that underwent subsequent dental implant therapy. CONCLUSIONS: High vertical bone gain and minimal post-surgical complications were associated with bone augmentation procedures preceded by soft tissue expansion (STE). 3.1. ABSTRACT To ensure a successful dental implant therapy, presence of adequate vertical and horizontal alveolar bone is fundamental. However, an insufficient amount of alveolar ridge in both dimensions is often encountered in dental practice due to the consequences of oral diseases and tooth loss. Although post-extraction socket preservation has been adopted to lessen the need for such invasive approaches, it utilizes bone-grafting materials, which have limitations that could negatively affect the quality of bone formation. To overcome the drawbacks of routinely employed grafting materials, bone-graft substitutes such as 3D-scaffolds have been recently investigated in the dental field. In this review, we highlight different biomaterials suitable for 3D-scaffold fabrication, with a focus on “3D-printed” ones as bone graft substitutes that might be convenient for various applications related to implant therapy. We also briefly discuss their possible adoption for periodontal regeneration. 4.1. ABSTRACT OBJECTIVES: To analyze bone resorption patterns in the posterior mandibles and their corresponding digitally designed bone grafts to understand if they come in distinct clusters. MATERIALS & METHODS: In this retrospective analysis, 120 CBCT scans were analyzed to evaluate the frequency of Cawood & Howell classification, in right and left posterior mandibles. Results were compared between gender and age. The most frequent atrophic class that needs bone augmentation was virtually regenerated in the mandibular segments using specific software. Height, width and length of the obtained grafts were analyzed to conclude if these grafts come in distinct clusters. RESULTS: Class V was the most frequent atrophic class in comparison to class IV & VI in the left and right posterior mandibles (16%, 20.8% respectively). Severe atrophic stages were more frequent in females (p= 0.029 for the left side, p= 0.007 for the right side) and in older age groups (p= 0.008 for the right side) After virtual regeneration of class V defects, three clusters were evident, differing only in length, based on the number of missing teeth (p= 0.0001). Height and width of the virtual grafts were comparable for the three clusters (p > 0.05). Mean virtual graft volume was 2,184 mm3 (four missing teeth), 1,819 mm3 (three missing teeth) & 1,476 mm3 (two missing teeth). CONCLUSIONS: Stage V atrophy was the most frequent resorption pattern in comparison to classes IV & V, in posterior mandibles. Virtual regeneration procedure revealed three clusters of virtual grafts, differing only in the length based on the number of missing teeth. Future studies are recommended to determine the adaptation ratio between virtual and actual grafts to bone surface.
Defay, David Kay. "3D facial analysis: unaffected parents of individuals with cleft lip/palate". Thesis, University of Iowa, 2011. https://ir.uiowa.edu/etd/944.
Texto completoCarrier-Vallières, Martin. "FDG-PET/MR Imaging for prediction of lung metastases in soft-tissue sarcomas of the extremities by texture analysis and wavelet image fusion". Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114330.
Texto completoLes sarcomes des tissus mous (STM) provenant des extrémités forment un groupe relativement rare de néoplasme avec un risque métastatique élevé. La grande majorité des métastases provenant des STM ont lieu dans les poumons, et le pronostique résultant est généralement faible. En ce sens, il est important d'identifier autant de facteurs pronostiques pertinents que possible au moment du diagnostique et de la gestion du traitement. Certains travaux récents ont permis de démontrer que les caractéristiques texturales d'images provenant de la tomographie par émission de positrons (TEP) utilisant le fluorodéoxyglucose (FDG) et l'imagerie par résonance magnétique (IRM) ont le potentiel de prédire l'évolution tumorale grâce à l'évaluation des propriétés d'hétérogénéité biologique des tumeurs. Donc, le but de ce travail est d'évaluer le potentiel des caractéristiques texturales d'images FDG-TEP et IRM en tant que prédicteur du risque de métastases aux poumons pour le cancer des STM provenant des extrémités. Dans cette étude, une cohorte de 35 patients diagnostiqués avec des STM aux extrémités a été rétrospectivement analysée. Tous les patients ont reçu un scan FDG-TEP et un scan IRM avant leur traitement. Les séquences IRM qui ont été utilisés dans l'analyse sont: T1, T2 par saturation des gras (T2FS) et STIR. Les patients ont été suivis sur une période médiane de 29 mois (intervalle: 4 à 85 mois). Treize patients de la cohorte ont développé des métastases aux poumons. Six caractéristiques texturales d'images provenant de la matrice de co-occurrence des niveaux de gris (GLCM) ont été extraites des scans FDG-PET, IRM et FDG-PET/IRM fusionnés. De plus, la valeur maximale de consommation standard des tumeurs (SUVmax) a été incluse dans l'analyse. La fusion des scans a été effectuée grâce à la transformée d'ondelettes discrètes et grâce à une technique de renforcement des fréquences passe-bandes. L'analyse statistique a été effectuée en utilisant la corrélation de Spearman (rho), et l'analyse multivariable en utilisant la régression logistique. Les performances de prédiction des différents modèles multivariables ont été évaluées en calculant 2 métriques à partir de la technique de ré-échantillonnage « bootstrap »: L'aire sous la courbe de fonctionnement (AUC) et le coefficient de corrélation de Matthews (MCC). La plus haute prédiction univariée est attribuée à SUVmax (rho=0.6382, p<0.0001). La plupart des caractéristiques texturales extraites des scans fusionnés possèdent des coefficients de corrélation Spearman plus haut que celles extraites des scans séparés. Dans le cas des scans séparés, les caractéristiques texturales provenant de FDG-TEP sont généralement dominantes par rapport à celles provenant des scans IRM. La plus haute prédiction multivariable est provenue des scans fusionnés avec le model suivant: 0.94*SUVmax − 0.401*PET-T2FS/STIR--Variance − 6.7*PET-T1--Contrast − 165*PET-T1--Homogeneity + 140. Ce model a atteint des résultats de rho=0.8255, p<0.0001 sur l'ensemble des patients et AUC=0.956±0.002, MCC=0.829±0.002 sur les ensembles de tests « bootstrap ». De façon générale, cette étude indique le fort potentiel des caractéristiques texturales provenant des images FDG-TEP et IRM pour prédire les métastases aux poumons dans le cas des patients atteints des STM aux extrémités. Une amélioration substantielle des prédictions a pu être obtenue en utilisant les caractéristiques texturales des scans fusionnés et des stratégies d'analyse multivariable comparativement aux caractéristiques texturales des scans séparés et à l'analyse univariée. Potentiellement, cela pourrait mener à l'application de stratégies préventives pour atténuer la propagation du cancer des STM et à l'application de traitements mieux adaptés aux besoins des patients.
Paredes, de Sousa Gil Ariane. "CBCT (cone-beam computerized tomography) evaluation of the nasolabial soft tissue effects of Le Fort I maxillary osteotomy". Doctoral thesis, Universitat Internacional de Catalunya, 2019. http://hdl.handle.net/10803/667624.
Texto completoGuyomarc'h, Pierre. "Reconstitution faciale par imagerie 3d : variabilité morphométrique et mise en oeuvre informatique". Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14354/document.
Texto completoFacial approximation aims at the production of a face based on the skull morphology. This technique is performed in forensic anthropology to bring new testimonies in cases of human remains identification. The goals of this research are to establish a database of French skulls and faces in 3D through medical imaging, to test traditional guidelines, and to quantify the morphological correlations between soft and hard tissues. Computed tomography exams, collected in French hospitals (18 – 96 years; sex ratio 1.16:1), were treated with TIVMI software to reconstruct accurately the bone and skin surfaces. More than 200 landmarks have been placed on 500 subjects, following a protocol which repeatability and reproducibility have been checked. The extraction of Euclidian distances allowed testing traditional guidelines, and studying specificity and variability of soft tissue depths. In parallel, the 3D coordinates were analyzed with geometric morphometrics. Covariations between groups of bone landmarks and groups of skin landmarks were quantified, along with asymmetry, allometry, and influences of age and sex on the shape changes. These results allowed for the creation of a method to estimate the position of skin landmarks, and for the development of a facial approximation module in TIVMI, called AFA3D (in collaboration with the LaBRI). Based on the warping of a synthetic face, this software renders the most probable face depending on the position of 78 cranial landmarks
Wang, Li-Ying y 王儷螢. "Soft-Tissue Prediction and Reconstruction after Craniofacial Surgery". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/31665863949470240606.
Texto completo長庚大學
資訊工程研究所
95
It is always desired for the patients to foresee the result of their own craniofacial surgeries, whether the operation is necessary (due to facial deform, etc.) or for aesthetic purpose. Post-treatment prediction of soft tissue has been the most challenging task in that the correlation between the soft- and hard-tissues may be altered. A semi-automatic process to characterize correspondence of the pre- and post-surgery and visualized assistance for the physician are thus in dire need. In this work, we propose a soft-tissue prediction and reconstruction procedure of the plastic facial surgery includes (1) analysis of craniofacial images, (2) identify the characteristics of the soft tissues, such as fat, skin, etc., and hard tissues, such as bones, (3) reconstruction the projected facial images with treated hard tissues covered with corresponding soft tissues, and finally (4) visualization of the three-dimensional facial model. We developed an interactive and dynamic system that the physician can follow the procedure or create his or her own surgical planning scheme.
Torres, Diana M. "3D soft tissue effects of rapid palatal expansion". Thesis, 2019. https://hdl.handle.net/2144/37029.
Texto completoFontenelle, Hugues. "Soft-tissue deformation prediction for maxillo-facial surgical planning". 2005. http://nemertes.lis.upatras.gr/jspui/handle/10889/430.
Texto completoHuang, Tzung-Chi y 黃宗祺. "3D Optical Flow Method for Soft Tissue Registration in Radiotherapy". Thesis, 2004. http://ndltd.ncl.edu.tw/handle/44822674196604383733.
Texto completo中原大學
電機工程研究所
92
Respiratory motion results in an added uncertainty in the radiation treatment of thoracic malignancies due to an increase in the normal tissue irradiated and an uncertainty in the radiation coverage of the tumor. This results in a potential increase in complications from treatment and may be insufficient to ensure coverage of the tumor. Reduction of the volume of normal tissue irradiation while maintaining tumor coverage is used to accomplish this goal. The application of 4D CT imaging to radiotherapy treatment planning is an active area of research with the goal to reduce the required normal tissue irradiation and improve the tumor coverage. In order to achieve adequate coverage of the tumor with a tumoricidal radiation dose a margin of normal tissue is also irradiated to high dose. With optical flow method the image content properties are utilized to generate a displacement vector between each voxel in the reference image to the target image for registration. In this study we develop and validate 3D optical flow method to measure intra-thoracic tumor motion from inspiration/expiration breath-hold CT image sets. Two important tools used in this study for validations are the 4D NCAT and 3D TPS, a computer generated phantom that simulates a thorax with both respiratory and cardiac motion and the elastic movement calculation.
Hosseinzadeh, Kambod. "The accuracy of computerized soft tissue prediction for growth modification treatment". 1996. http://catalog.hathitrust.org/api/volumes/oclc/47970066.html.
Texto completoYeh, Kai-Jing y 葉凱菁. "Hard and soft tissue evaluation of facial asymmetry: 3D analysis using CBCT". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/4967yz.
Texto completo國立臺灣大學
臨床牙醫學研究所
106
Objective: The purpose of this study is to evaluate facial asymmetry 3 dimensionally using cone-beam computed tomography (CBCT) in skeletal Class III patients. Material and methods: The patients were classified into 3 groups based on the relationship of direction and amount of menton deviation relative to the transverse ramus width asymmetry. In groups 1 and 2, menton deviation was accompanied by a larger transverse ramus distance on the deviated side. While in group 1 the amount of menton deviation was greater than that of ramus asymmetry, group 2 patients showed a smaller menton deviation in comparison to ramus asymmetry. Patients in group 3 exhibited an atypical asymmetry of larger ramus distance contralateral to the side of menton deviation. Statistical analysis was run to compare hard/ soft tissue characteristics between the deviation side and non-deviation side in each group. Difference of the structural characteristics among 3 groups were also delineated by using one-way ANOVA and posy-hoc tests. Results: Group 1 showed the greatest amount of menton deviation. Significant greater transverse dimension of maxilla and mandible were noted for the deviation side. In addition, maxilla exhibited downward canting in the non-deviation side, and the ramus of the deviation side was more buccal inclined than that of the non-deviation side. The bucco-lingual axes of maxillary first molars were compensated to transverse skeletal asymmetry, which resulted in canting in the maxillary occlusal plane. In contrast, no significant difference in soft tissue thickness between the deviation side and the non-deviation side was observed. Group 2 showed the lowest amount of menton deviation. Significant greater transverse dimension of maxilla and mandible were observed at the deviation side. No significant difference was noted in the bucco-lingual tooth axis of bilateral maxillary first molars nor dentoalveolar heights was observed between the deviated and non-deviated sides. There was no significant difference in soft tissue thickness between the deviation and non-deviation sides. In group 3, the Jugular point was more anterior positioned in the non-deviation side than the deviation side. The transverse dimension of mandible was significant greater at the non-deviation side. The asymmetry in bucco-lingual inclination of bilateral maxillary first molars was not statistically significant, suggesting that no obvious dental compensation existed. However, the soft tissue thickness was significant greater at the deviation side. The Jugular-C measurement was significant different between the 3 groups. In group 1 and 3, the Jugular point was more anteriorly positioned at the non-deviated side than the deviation side. Most of the measurements representing mandibular structures were significant different among 3 groups. Similarly, in group 1 and 3, the mandibular foramen and mental foramen were more anteriorly positioned at the non-deviation side. Group 1 exhibited more buccally inclined ramus at the deviation side than the other 2 groups. Group 3 showed the smallest amount of transverse width discrepancy between bilateral ramus. There were significant differences in the measurements of maxilla U6 canting and maxilla U6 dimension difference between 3 groups. Group 1 showed greatest maxilla U6 canting and transverse width discrepancy. All the soft tissue measurements were significant different among the 3 groups. The lip canting was of greatest amount in group 1. Group 3 exhibited the greatest difference in the bilateral soft tissue thickness of the lower face. Conclusion Different structural characteristics were found among 3 groups. In Group 1 patients, the maxillomandibular complex exhibited displacement including a roll rotation in frontal view and a yaw rotation in axial view to the deviation side. As to group 2 patients, facial asymmetry was characterized by mandible sideshift to the deviation side. Abruptly, the maxillomandibular complex of group 3 patients exhibited a yaw rotation to the deviation side.
Chang, Yu Jen y 張毓仁. "3D Soft Tissue Changes Responding to Hard Tissue Movements after Bimaxillary Orthognathic Surgery–Clinical Application of Computer-Aided Simulated Navigation". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/54j9rt.
Texto completo長庚大學
顱顏口腔醫學研究所
104
Objective 3D simulated navigation in OGS is a technique that provides support during surgery and provides a bony "guiding splint" to precisely place the bony segments into the planned position. The aim of this study was to analyze the pre- and post-surgical soft-tissue and hard-tissue correlations, ratios, and regressions of patients following our Computer-Aided Three-Dimensional Simulation and Navigation in OGS (CASNOS) procedures. Material/Methods Forty adult patients at Kaohsiung Chang Gung Memorial Hospital, Taiwan (n=40; 11 men, 29 women; age, 23.5±4.9 years) undergoing 2-jaw OGS (maxillary Le Fort I osteotomy and mandible bilateral sagittal split osteotomy) were selected retrospectively after excluding for craniofacial syndromes. Each patient had complete records, including CT imaging data from 3 weeks before surgery to 6 months after surgery. We used two open-source software: ITK-SNAP and 3D-Slicer to analyze 15 landmarks in hard tissue and corresponding soft tissue 3-D movement; then subdivided all 40 cases into two groups: Clockwise/Counter-Clockwise rotation, and Symmetry/Asymmetry to determine the correlations, ratios, and regression between soft-hard-tissue. Results (1) We found a high correlation between 3D skin and bone changes, and especially, AP direction was the most important factor responsible for soft tissue movement in all these three directions. (2) The ratio of 3D skin/bone was as follows: ANS/tip of Nose = 0.54, A/Subnasale = 0.58, Upper lip/Upper central incisor = 0.67, Lower lip/ Lower central incisor =0.76, B/Si =0.93, Pog =0.92, and Me =0.92. (3) We also found that the regression of 3D SOFT TISSUE = a0+a1*BONEAP+ a2*BONEVer.+ a3*BONELat. Conclusion 3D analysis can help predict soft-tissue profile while simulating bony movement. Our study provides 3D quantitative data of OGS planning by using 3D CT simulation and navigation. In the future, we can use 3D surface simulation to actually predict the surgical outcome.
Codinha, Sónia Cristina Fialho. "Facing the dead : prediction of facial soft tissue depths from craniometric dimensions for forensic craniofacial identification". Doctoral thesis, 2010. http://hdl.handle.net/10316/14580.
Texto completoTsui, Patrick Pak Chuen. "A Multi-scale Stochastic Filter Based Approach to Inverse Scattering for 3D Ultrasound Soft Tissue Characterization". Thesis, 2009. http://hdl.handle.net/10012/4839.
Texto completoHuang, Shu-Yen y 黃書彥. "Study of Visible-Light Induced Poly(ethylene glycol)-Based 3D Matrix for Facilitating Soft Tissue Repair". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/t78a79.
Texto completo國立中興大學
生醫工程研究所
102
Biocompatible three-dimensional (3D) matrices can mimic the living body environment for cell growth and further construct a biological tissue for tissue repair. 3D matrices have been drawn a lot of attentions because of their customized structures and tailor-made mechanical and chemical properties for cellular proliferation and survival after integrating with specific extracellular matrix (ECM) or biomolecules. This study is based on 3T3 fibroblasts laden 3D poly(ethylene glycol) (PEG)-hybrid biomaterial for soft tissue repair. Visible-light sensitive 3D polymer precursor solution was first prepared by mixing PEG and photosensitive PEG diacrylate (PEGDA) with ratio of 1 to 5 and further supplemented with RGD(Arg-Gly-Asp) or PRP(Platelet Rich Plasma) to form the main structure of synthesized polymer material. 3T3 fibroblasts laden RGD or PRP supplemented PEG-hybrid biomaterials were used to in vitro and in vivo evaluate their cellular proliferation and biocompatibility. Our in vitro results showed PEG-hybrid supplemented with RGD or PRP had better cellular proliferation and biocompatibility than PEG-hybrid material. After that, the cell-laden RGD or PRP supplemented 3D matrices were implanted in living mice for in-vivo evaluation of soft tissue repair. The histological examinations were used to determine the responses after 2-wk and 4-wk implantation. Our results showed RGD supplemented PEG-hybrid material had high inflammation responses after 2-wk implantation. The inflammation responses obviously decreased after 4-wk implantation. PRP supplemented PEG-hybrid material showed less the inflammation responses but higher fibrosis than RGD after 2-wk implantation. In addition, our results showed the implantation of cell-laden RGD or PRP supplemented PEG-hybrid structures has an impact on regeneration of neovessels and cell infiltration within implanted structures in 2-wk.
Leng, Lian. "Flow-based Organization of Perfusable Soft Material in Three Dimensions". Thesis, 2010. http://hdl.handle.net/1807/24259.
Texto completoBhattacharjee, Abhinaba. "A Data Requisition Treatment Instrument For Clinical Quantifiable Soft Tissue Manipulation". Thesis, 2019. http://hdl.handle.net/1805/19009.
Texto completoSoft tissue manipulation is a widely used practice by manual therapists from a variety of healthcare disciplines to evaluate and treat neuromusculoskeletal impairments using mechanical stimulation either by hand massage or specially-designed tools. The practice of a specific approach of targeted pressure application using distinguished rigid mechanical tools to breakdown adhesions, scar tissues and improve range of motion for affected joints is called Instrument-Assisted Soft Tissue Manipulation (IASTM). The efficacy of IASTM has been demonstrated as a means to improve mobility of joints, reduce pain, enhance flexibility and restore function. However, unlike the techniques of ultrasound, traction, electrical stimulation, etc. the practice of IASTM doesn't involve any standard to objectively characterize massage with physical parameters. Thus, most IASTM treatments are subjective to practitioner or patient subjective feedback, which essentially addresses a need to quantify therapeutic massage or IASTM treatment with adequate treatment parameters to document, better analyze, compare and validate STM treatment as an established, state-of-the-art practice. This thesis focuses on the development and implementation of Quantifiable Soft Tissue Manipulation (QSTM™) Technology by designing an ergonomic, portable and miniaturized wired localized pressure applicator medical device (Q1), for characterizing soft tissue manipulation. Dose-load response in terms of forces in Newtons; pitch angle of the device ; stroke frequency of massage measured within stipulated time of treatment; all in real-time has been captured to characterize a QSTM session. A QSTM PC software (Q-WARE©) featuring a Treatment Record System subjective to individual patients to save and retrieve treatment diagnostics and a real-time graphical visual monitoring system has been developed from scratch on WINDOWS platform to successfully implement the technology. This quantitative analysis of STM treatment without visual monitoring has demonstrated inter-reliability and intra-reliability inconsistencies by clinicians in STM force application. While improved consistency of treatment application has been found when using visual monitoring from the QSTM feedback system. This system has also discriminated variabilities in application of high, medium and low dose-loads and stroke frequency analysis during targeted treatment sessions.
Southers, Erik Leroy. "The accuracy of Quick Ceph imaging software in the prediction of soft tissue profiles associated with mandibular advancements of differing magnitude". 1999. http://catalog.hathitrust.org/api/volumes/oclc/48108308.html.
Texto completoEder, Simone Gabriele [Verfasser]. "3D-histology and malignant soft tissue sarcomas of the skin : local recurrence rate and growth pattern / vorgelegt von Simone Gabriele Eder". 2007. http://d-nb.info/983727740/34.
Texto completoAlotaibi, Ahmed Mohammed. "Development of a Mechatronics Instrument Assisted Soft Tissue Mobilization (IASTM) Device to Quantify Force and Orientation Angles". Thesis, 2016. http://hdl.handle.net/1805/10333.
Texto completoInstrument assisted soft tissue mobilization (IASTM) is a form of massage using rigid manufactured or cast devices. The delivered force, which is a critical parameter in massage during IASTM, has not been measured or standardized for most clinical practices. In addition to the force, the angle of treatment and frequency play an important role during IASTM. As a result, there is a strong need to characterize the delivered force to a patient, angle of treatment, and stroke frequency. This thesis proposes two novel mechatronic designs for a specific instrument from Graston Technique(Model GT3), which is a frequently used tool to clinically deliver localize pressure to the soft tissue. The first design is based on compression load cells, where 4-load cells are used to measure the force components in three-dimensional space. The second design uses a 3D load cell, which can measure all three force components force simultaneously. Both designs are implemented with IMUduino microcontroller chips which can also measure tool orientation angles and provide computed stroke frequency. Both designs, which were created using Creo CAD platform, were also analyzed thorough strength and integrity using the finite element analysis package ANSYS. Once the static analysis was completed, a dynamic model was created for the first design to simulate IASTM practice using the GT-3 tool. The deformation and stress on skin were measured after applying force with the GT-3 tool. Additionally, the relationship between skin stress and the load cell measurements has been investigated. The second design of the mechatronic IASTM tool was validated for force measurements using an electronic plate scale that provided the baseline force values to compare with the applied force values measured by the tool. The load cell measurements and the scale readings were found to be in agreement within the expected degree of accuracy. The stroke frequency was computed using the force data and determining the peaks during force application. The orientation angles were obtained from the built-in sensors in the microchip.
Tsai, Tsung-Yuan y 蔡宗遠. "Development of a 3D Fluoroscopy Method and its Integration with Stereophotogrammetry to Study the Effects of Soft Tissue Artifacts on the Calculated Mechanical Variables of the Knee During Functional Activities". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/16552219252804844742.
Texto completo臺灣大學
醫學工程學研究所
98
Accurate measurement of the three-dimensional (3D) rigid body and surface kinematics of the natural and implanted knee is essential for many clinical applications. Skin marker-based stereophotogrammetry has been widely used in the in vivo, non-invasive measurement of 3D joint kinematics. However, the measured poses of body segments are subject to errors called soft tissue artifacts (STA). Existing techniques are limited either in their accuracy or lack of more realistic experimental evaluation of the measurement errors. The purposes of the study were to develop a volumetric model-based 2D-to-3D registration method, called the weighted edge-matching score (WEMS) method, for measuring accurate natural and implanted knee kinematics with single-plane fluoroscopy; to assess the 3D movement of skin markers relative to the underlying bones in normal subjects during functional activities; to access the effects of STA on the calculated joint variables at the knee in normal subjects during stair-ascent (SA); to quantify the STA and their effects on the calculated variables of the knee in patients with total knee replacements (TKR) during sit-to-stand (STS); and to validate the performance and effectiveness of global optimization method (GOM) with an appropriate kinematic model for compensating the STA for in vivo knee kinematics of normal, anterior cruciate ligament deficient (ACLD) and TKR subjects during functional activities. The precision of the WEMS method has been determined experimentally with cadaver knee and TKR. With the help of integrated 3D fluoroscopy method and stereophotogrammetry, considerable STA of normal and TKR subjects, during SA and STS respectively, were found and which led to significant differences of measured biomechanical variables of the knee. Compensating the effects of STA with GOM showed that the mean values of root mean squared error (RMSE) over all functional activities of all kinds of subjects were in the order of 3-6 mm for measurement of knee joint translations and about 3˚ for knee joint rotations. These findings suggested that GOM would be helpful for compensating STA in human motion analysis for basic research and clinical applications.
Li, Jia-Da y 李佳達. "Development of 2D-3D Registration Methods for Alternating Biplane Fluoroscopy to Quantify Soft Tissue Artefacts in the Lower Limb and Their Effects on Mechanical Analysis of the Knee During Pedalling". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/3ws4gv.
Texto completo國立臺灣大學
醫學工程學研究所
106
Soft tissue artefacts (STA) have been recognized as a major source of error as applying stereophotogrammetry for human movement analysis. It not only affects the measurement of cycling motion but also limits interpretation of the results from the stereophotogrammetry-based measurement system. Currently, study of STA absent detailed, substantial results which provide guidelines for properly interpret results of cycling. 2D-3D subject-specific model-based registration method combined with biplane fluoroscopy is considered as a non-invasive accurate measurement method. However, the technique design for alternating exposures used in clinical system is not been proposed yet. Therefore, the study aims to develop 2D-3D registration methods for alternating biplane fluoroscopy and used to quantify soft tissue artefacts in the lower limb and their effects on mechanical analysis of the knee during pedalling. A tri-alternating images registration method is proposed combined with three kinematic models (constant speed, rigid and quasi-rigid) which help to predict bone pose of the adjacent frame under sole biplane fluoroscopy or combined with assistant measurement system conditions. The methods were verified by a cadaver study. Compare to single plane and pseudo biplane registration results, fast correction algorithm based on constant speed model already decreased 89% of out-of-plane errors and the target registration error eventually less than 0.7 mm. Performance of three models were comparable to the synchronized biplane registration. The rigid kinematic model was adopted for subsequence in vivo STA quantification during pedalling. Compare to the shank markers, the thigh markers showed greater STA and were affected more by pedal resistance. The STA varied with angles of the adjacent joints, largely linearly for shank markers while non-linearly for thigh markers. Markers near a joint experienced greater ranges of STA than mid-segment markers, but tended to have smaller variation. To estimate bone pose, STA produce greater rigid translations and rotations than the nonrigid component. Range of norigid component may not able to represent accuracy of the marker cluster used to estimate bone pose. On mechanical analysis, calculated joint angles were not affected by different resistant condition. Hybrid two marker clusters to estimate bone orientation and position separately help to reduce error of calculated joint angles and moments. The method developed in the study help to apply clinical sytem for measuring accurate bone kinematics. Results of STA during pedalling help other cycling study and the experiment data will be useful for the further studies.
(9183650), Andrea Acuna. "Characterizing the mechanical behavior of extracellular matrix networks in situ". Thesis, 2020.
Buscar texto completoThe extracellular matrix (ECM) plays a significant role in defining the mechanical properties of biological tissues. The proteins, proteoglycans, and glycosaminoglycans that constitute the ECM are arranged into highly organized structures (e.g. fibrils and networks). Cellular behavior is affected by the stiffness of the microenvironment and influenced by the composition and organization of the ECM. Mechanosensing of ECM stiffness by cells occurs at the fibrillar (mesoscale) level between the single molecule (microscale) and the bulk tissue (macroscale) levels. However, the mechanical behavior of ECM proteins at the mesoscale are not well defined. Thus, better understanding of the ECM building blocks responsible for functional tissue assembly is critical in order to recapitulate in vivo conditions. There is a need for the mechanical characterization of the ECM networks formed by proteins synthesized in vivo while in their native configuration.
To address this gap, my goals highlighted in this dissertation were to develop appropriate experimental and computational methodologies and investigate the 3D organization and mechanical behavior of ECM networks in situ. The ECM of developing mouse tissues was used as a model system, taking advantage of the low-density networks present at this stage. First, we established a novel decellularization technique that enhanced the visualization of ECM networks in soft embryonic tissues. Based on this technique, we then quantified tissue-dependent strain of immunostained ECM networks in situ. Next, we developed mesoscale and macroscale testing systems to evaluate ECM networks under tension. Our systems were used to investigate tendon mechanics as a function of development, calculating tangent moduli from stress - strain plots. Similarly, we characterized ECM network deformation while uniaxially loading embryonic tissues, since this testing modality is ideal for fibril and network mechanics. Taken together, this information can facilitate the fabrication of physiologically relevant scaffolds for regenerative medicine by establishing mechanical guidelines for microenvironments facilitate functional tissue assembly.