Bibliografías temáticas / 320.5/8

Literatura académica sobre el tema "320.5/8"

Autor: Grafiati
Publicado: 25 de julio de 2024
Última modificación: 29 de julio de 2024

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Artículos de revistas sobre el tema "320.5/8"

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Yaish, Hassan M., Maria Sol Cruz, Kay Decker, Eva M. K. Zetterberg, Sylvia Werner, Mariko Hashimoto, Sigurd Knaub y George M. Rodgers. "Final Results from a Non-Interventional Safety and Efficacy Study of a VWF/FVIII Concentrate (wilate®) in Patients with Von Willebrand Disease". Blood 132, Supplement 1 (29 de noviembre de 2018): 1182. http://dx.doi.org/10.1182/blood-2018-99-118069.

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Abstract Introduction: Post-marketing studies provide important insight into the consistency of data from clinical studies and routine clinical use. This non-interventional, prospective, multicentre study (WIL-20) collected real-life data on the use of a human VWF/FVIII concentrate with the native VWF/FVIII complex in a physiological 1:1 ratio (wilate®; pdVWF/FVIII) in routine clinical practice. Here, we report the final results from this study. Methods: The primary objective was to document the safety and tolerability of pdVWF/FVIII in routine clinical practice, with a planned observation period per patient of 2 years. Secondary objectives were to document the efficacy in on-demand treatment of acute bleeding, long-term prophylaxis, and surgical prophylaxis. Male and female patients of any age and with any type of VWD who were prescribed pdVWF/FVIII were eligible for the study. pdVWF/FVIII was administered at the investigator's discretion. Data recorded included patient demographics, laboratory parameters, treatment details, and occurrence of adverse drug reactions (ADRs), including immunogenicity and thrombogenicity. Tolerability was assessed using a verbal rating scale; efficacy of on-demand treatment and surgical prophylaxis using a haemostatic scale; and prophylactic efficacy based on the frequency of spontaneous breakthrough bleeds. Results: The study enrolled 120 patients from 11 countries. Within the safety population (111 patients who received at least one dose of pdVWF/FVIII), 45% of patients had type 1 VWD, 29% type 2 and 18% type 3; disease type was unavailable for 8 patients, and 1 patient was diagnosed with haemophilia A during the study. Of the 111 patients, 33% were previously untreated with a FVIII/VWF product. A total of 7024 infusions were administered to the safety population over a median observation time of 2 years; median dose was 320.5 IU/kg. A total of 26 ADRs were reported in 8 patients; 4 were mild, 3 moderate and 1 severe. Three patients discontinued treatment and 1 stopped treatment temporarily due to adverse events. Using an experimental assay, 3 cases of VWF inhibitors were identified, with no impact on clinical outcome. No thromboembolic events were reported. Tolerability was rated for 6497 infusions, with 96.2% rated 'excellent', 3.7% 'satisfactory', and 0.1% 'unsatisfactory'. Of the 29 patients treated on-demand, 150 bleeding events (BEs), excluding menstrual bleeds, were reported in 25 patients; 18% of BEs were mild, 71.3% were moderate, and 10% were severe. 94% of treated bleeds (130/138) resolved with 1 or 2 infusions, with a median dose per BE of 33 IU/kg. The efficacy of treatment was rated as 'excellent' or 'good' for 100% of BEs. Of the 25 patients treated with pdVWF/FVIII for prophylaxis, 18 patients had a total of 233 breakthrough BEs; 37% mild, 44% moderate, and 9% severe (severity information was unavailable for 11% of bleeds). Of the breakthrough BEs that required treatment, 85% (149/175) were treated with 1 or 2 infusions of pdVWF/FVIII, with a median dose per BE of 55.4 IU/kg. Efficacy of pdVWF/FVIII was rated as 'excellent' or 'good' by investigators for 99% of 139 evaluable breakthrough BEs. For patients on prophylaxis (n = 25), the median annualised bleeding rate for spontaneous BEs was 1.5 (range 0.0-19.7). The efficacy of prophylaxis for prevention of spontaneous breakthrough bleeds was rated as 'excellent' or 'good' in 96% (24/25) of these patients. A total of 99 surgical procedures were performed in 62 patients; 56% with type 1 VWD, 29% type 2 and 13% type 3 (2% were type unknown). Of the procedures, 46 were major and 53 minor. All but one of the surgeries were managed with pdVWF/FVIII prophylaxis, and the efficacy was rated as 'excellent' or 'good' in 99% (96/97) of surgeries with assessments available. Conclusions: The final results of this non-interventional study indicate that pdVWF/FVIII is well tolerated and effective for on-demand treatment, prophylaxis, and surgical prophylaxis in patients with all types of VWD treated as part of routine clinical practice. The data are consistent with those from previous clinical studies and provide real-life evidence from around the world on the use of pdVWF/FVIIIfor management of VWD in all clinical settings. Disclosures Werner: Octapharma USA Inc.: Employment. Hashimoto:Octapharma USA Inc.: Employment. Knaub:Octapharma AG: Employment. Rodgers:Octapharma: Membership on an entity's Board of Directors or advisory committees, Research Funding.
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Jones, Jane H., Bohumil Štíbr, John D. Kennedy y Mark Thornton-Pett. "Ten-Vertex Polyhedral Monocarbaborane Chemistry. The Novel High-Yield Formation of the Ten-Vertex closo Compound [6-(PMe2Ph)-closo-1-CB9H9] from the Thermolysis of [8,8-(PMe2Ph)2-nido-8,7-PtCB9H11]". Collection of Czechoslovak Chemical Communications 58, n.º 12 (1993): 2924–35. http://dx.doi.org/10.1135/cccc19932924.

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Thermolysis of [8,8-(PMe2Ph)2-nido-8,7-PtCB9H11] in boiling toluene solution results in an elimination of the platinum centre and cluster closure to give the ten-vertex closo species [6-(PMe2Ph)-closo-1-CB9H9] in 85% yield as a colourles air stable solid. The product is characterized by NMR spectroscopy and single-crystal X-ray diffraction analysis. Crystals (from hexane-dichloromethane) are monoclinic, space group P21/c, with a = 903.20(9), b = 1 481.86(11), c = 2 320.0(2) pm, β = 97.860(7)° and Z = 8, and the structure has been refined to R(Rw) = 0.045(0.051) for 3 281 observed reflections with Fo > 2.0σ(Fo). The clean high-yield elimination of a metal centre from a polyhedral metallaborane or metallaheteroborane species is very rare.
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3

Baillif, Stéphanie, Pascal Staccini, Michel Weber, Marie-Noëlle Delyfer, Yannick Le Mer, Vincent Gualino, Laurence Collot et al. "Management of Patients with Diabetic Macular Edema Switched from Dexamethasone Intravitreal Implant to Fluocinolone Acetonide Intravitreal Implant". Pharmaceutics 14, n.º 11 (5 de noviembre de 2022): 2391. http://dx.doi.org/10.3390/pharmaceutics14112391.

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To assess anatomical and functional outcomes after switching from dexamethasone implant (DEXi) to fluocinolone acetonide implant (FAci) in 113 diabetic macular edema eyes, a multicentric retrospective observational study was conducted. Seventy-five eyes (73.5%) were switched 1–8 weeks after their last DEXi. The mean best-corrected visual acuity improved to 59.8 letters at month 4 and remained stable during the follow-up. The mean central macular thickness (CMT) significantly decreased during the follow-up, with a minimum of 320.9 μm at month 3. The baseline CMT was higher in eyes that received the last DEXi >8 weeks versus <8 weeks before the first FAci (p < 0.021). After FAci injection, additional treatments were needed in 37 (32.7%) eyes. A longer diabetes duration (p = 0.009), a longer time between the last DEXi and the first FAci (p = 0.035), and a high baseline CMT (p = 0.003) were risk factors for additional treatments. The mean intraocular pressure was <19 mmHg at all timepoints, with no difference between eyes receiving the last DEXi ≤8 weeks or >8 weeks before the switch. Switching from DEXi to FAci in DME is effective and safe. A short time between the last DEXi and the first FAci reduced CMT fluctuations and the need for early additional treatments.
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Xu, Ping. "Comparison of cytotoxicity evaluation of chlorogenic acid extract between Real-time cell analysis and CCK-8 method". Ukrainian Journal of Veterinary and Agricultural Sciences 4, n.º 2 (21 de junio de 2021): 58–61. http://dx.doi.org/10.32718/ujvas4-2.10.

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Critical cytotoxicity evaluation of pharmaceuticals is necessary for the clinical practice of chemotherapy. To quantitatively evaluate cell viability, currently there are two main types of sensitive methods including real-time cell analysis (RTCA) and CCK-8 assay, in which RTCA records electrochemical signal changes around an incubated cell, whereas CCK-8 is based on the colorimetric method. Despite the different detection principles adopted for the cytotoxicity assessment, the comparison of the two methods in terms of the application scope is lacking. In order to compare and determine the best experimental method for the study of the toxicity of chlorogenic acid extract from taraxacum officinale on dairy cow mammary epithelial cells. The real time cell analysis (RTCA) and CCK-8 method were used to analyze the cytotoxicity of chlorogenic acid extract to BMEC and calculate its IC50. The results of the real time cell analysis method and the CCK-8 method showed that different concentrations of chlorogenic acid extract reduced the viability of dairy cow mammary epithelial cells, and the decrease was most obvious at 400 ug/mL. The IC50 of the two analysis methods were 326.8 and 320.4 ug/mL, respectively. In contrast, the CCK-8 method had limitations in fixed-point determination. However, the real time cell analysis method can monitor the dynamic biological response process of cell growth and proliferation in real time. Therefore, the real time cell analysis method can observe cell growth more intuitively and accurately, compensate for the shortcomings of the CCK-8 method, and it is a new experimental method for studying cytotoxicity.
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FLEISCHMANN, ROY M., ANNE-MARIE HALLAND, MAREK BRZOSKO, RUBEN BURGOS-VARGAS, CHRISTOPHER MELA, EMMA VERNON y JOEL M. KREMER. "Tocilizumab Inhibits Structural Joint Damage and Improves Physical Function in Patients with Rheumatoid Arthritis and Inadequate Responses to Methotrexate: LITHE Study 2-year Results". Journal of Rheumatology 40, n.º 2 (15 de enero de 2013): 113–26. http://dx.doi.org/10.3899/jrheum.120447.

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Objective.To assess radiographic progression, physical function, clinical disease activity, and safety in patients with rheumatoid arthritis (RA) who had inadequate response to methotrexate (MTX) and who were treated with tocilizumab-MTX or MTX during Year 2 of a 2-year study.Methods.During Year 1, patients were randomized to placebo-MTX, 4 mg/kg tocilizumab-MTX, or 8 mg/kg tocilizumab-MTX. During Year 2, patients continued the initial double-blind treatment or switched to open-label 8 mg/kg tocilizumab-MTX. Co-primary endpoints at Week 104 were mean change from baseline in Genant-modified Total Sharp Score (GmTSS) and adjusted mean area under the curve (AUC) for change from baseline in the Health Assessment Questionnaire–Disability Index (HAQ-DI). Signs and symptoms of RA and safety were also evaluated.Results.At Week 104, mean change from baseline in GmTSS was significantly lower for patients initially randomized to tocilizumab-MTX 4 mg/kg (0.58; p = 0.0025) or 8 mg/kg (0.37; p < 0.0001) than for patients initially randomized to placebo-MTX (1.96). Adjusted mean AUC of change from baseline in HAQ-DI was also significantly lower in patients initially randomized to tocilizumab-MTX 4 mg/kg (–287.5; p < 0.0001) or 8 mg/kg (–320.8; p < 0.0001) than in patients initially randomized to placebo-MTX (–139.4). Signs and symptoms of RA were maintained or showed improvement. No new safety signals were noted.Conclusion.Compared with placebo-MTX, tocilizumab-MTX significantly inhibited structural joint damage and improved physical function in patients with RA who previously had inadequate response to MTX. An extension of this study is continuing and will provide additional longterm efficacy and safety data. National Clinical Trials registry NCT00106535.
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Kersten, Sebastian, Robert Prill, Hassan Tarek Hakam, Hannes Hofmann, Mahmut Enes Kayaalp, Jan Reichmann y Roland Becker. "Postoperative Activity and Knee Function of Patients after Total Knee Arthroplasty: A Sensor-Based Monitoring Study". Journal of Personalized Medicine 13, n.º 12 (21 de noviembre de 2023): 1628. http://dx.doi.org/10.3390/jpm13121628.

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Inertial measurement units (IMUs) are increasingly being used to assess knee function. The aim of the study was to record patients’ activity levels and to detect new parameters for knee function in the early postoperative phase after TKA. Twenty patients (n = 20) were prospectively enrolled. Two sensors were attached to the affected leg. The data were recorded from the first day after TKA until discharge. Algorithms were developed for detecting steps, range of motion, horizontal, sitting and standing postures, as well as physical therapy. The mean number of steps increased from day 1 to discharge from 117.4 (SD ± 110.5) to 858.7 (SD ± 320.1), respectively. Patients’ percentage of immobilization during daytime (6 a.m. to 8 p.m.) was 91.2% on day one and still 69.9% on the last day. Patients received daily continuous passive motion therapy (CPM) for a mean of 36.4 min (SD ± 8.2). The mean angular velocity at day 1 was 12.2 degrees per second (SD ± 4.4) and increased to 28.7 (SD ± 16.4) at discharge. This study shows that IMUs monitor patients’ activity postoperatively well, and a wide range of interindividual motion patterns was observed. These sensors may allow the adjustment of physical exercise programs according to the patient’s individual needs.
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Tomita, K., H. Nonoguchi, Y. Terada y F. Marumo. "Effects of ET-1 on water and chloride transport in cortical collecting ducts of the rat". American Journal of Physiology-Renal Physiology 264, n.º 4 (1 de abril de 1993): F690—F696. http://dx.doi.org/10.1152/ajprenal.1993.264.4.f690.

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Endothelin-1 (ET-1) is known as a vasoconstrictor peptide. However, recent reports suggested the effects on the transport of renal tubule. We previously reported that ET-1 inhibited arginine vasopressin (AVP)-dependent adenosine 3',5'-cyclic monophosphate in rat collecting ducts. Physiologically, ET-1 reversibly and significantly inhibited AVP-stimulated water permeability in inner medullary collecting duct (IMCD). We therefore investigated the effects on water and electrolyte transport in rat cortical collecting ducts (CCD), where Na and Cl are actively reabsorbed more than in IMCD. Pathogen-free male Sprague-Dawley rats weighing 80-120 g were used after treatment with deoxycorticosterone pivalate for 1-2 wk. Isolated CCD were microperfused in vitro. The Cl concentration was measured by a continuous-flow ultra-microcolorimeter, and the raffinose concentration was measured as a volume marker by a continuous-flow ultra-microfluorometer. In the presence of 10(-9) M AVP, 10(-8) M ET-1 significantly inhibited fluid absorption (nl.mm-1 x min-1) from 0.25 +/- 0.02 to 0.15 +/- 0.05 (mean +/- SE, n = 6, P < 0.01), Cl absorption (pmol.mm-1 x min-1) from 30. 6 +/- 2.8 to 14.9 +/- 4.0 (P < 0.01), and potential difference (mV) from -5.4 +/- 1.3 to -4.0 +/- 1.2 (P < 0.01). Similar results were obtained in the lower concentration of 10(-10) M AVP and 10(-10) M ET-1. As for the osmotic water permeability (microns/s), 10(-8) M ET-1 significantly inhibited this from 320.1 +/- 50.9 to 202.1 +/- 42.2 (n = 7, P < 0.01) in the presence of 10(-9) M AVP.(ABSTRACT TRUNCATED AT 250 WORDS)
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Abbasi, S. y A. Honaramooz. "305 OPTIMIZING DONOR AND RECIPIENT FACTORS IN XENOGRAFTING OF TESTIS TISSUE". Reproduction, Fertility and Development 22, n.º 1 (2010): 308. http://dx.doi.org/10.1071/rdv22n1ab305.

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Grafting of donor mammalian testis tissue into recipient mice allows completion of spermatogenesis in the grafted tissue and therefore can serve as a new option for preservation of male germ line. For testis tissue xenografting, castrated male nude mice typically serve as recipients, each receiving 8 testis tissue fragments; however, no study has comprehensively investigated donor and recipient factors. The objective of this study was to determine the effects of strain of immunodeficient recipient mouse (nude v. SCID), gonadal status (intact v. gonadectomized), and gender (male v. female) on the outcome of testis tissue xenografting. A secondary objective was to determine the optimal number of testis tissue fragments per mouse most suitable for xenografting. Testis parenchyma from newborn piglets were cut into small fragments (5 mg each) and grafted under the back skin of different groups of immunodeficient mice. In Experiment 1, 8 groups of mice (n = 7/group) served as recipients: castrated male nude, intact male nude, ovariectomized female nude, intact female nude, castrated male SCID, intact male SCID, ovariectomized female SCID, and intact female SCID. In Experiment 2, 4 groups of mice (n = 10/group) served as recipients of 2, 4, 8, or 16 testis tissue fragments per mouse. Recipient mice were sacrificed 8 months after grafting and the weight of the grafts and vesicular glands (male mice) were compared among groups by analysis of variance. In Experiment 1, mouse gonadal status (intact v. gonadectomized) did not affect the total graft weight (P > 0.05), but both the recipient mouse strain (nude v. SCID) and gender (male v. female) affected the total graft weight (2460 ± 320.9, 1420 ± 290.0, 758 ± 156.7, and 2780 ± 297.4, mean ± SEM, P < 0.0001 for SCID, nude, female, and male mice, respectively). In Experiment 2, the total graft weight was highest in the group of mice receiving 8 testis tissue fragments (192 ± 76.1, 695 ± 96.5, 2443 ± 338.8, and 1458 ± 305.4, mean ± SEM, P < 0.0001 for 2, 4, 8, or 16 fragment groups, respectively). These results collectively indicate that male SCID mice receiving 8 testis tissue fragments provide optimized conditions for the recovery of largest grafts. Research was supported by grants from the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Saskatchewan Health Research Foundation (SHRF) to A. Honaramooz and scholarships from the Western College of Veterinary Medicine and the International Peace Scholarship to S. Abbasi.
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Singh, Akanksha y Ram Pal Singh. "Study of Interrelationship among Economically Important Production Traits and Season of Calving on Milk Production in Jersindh Crosses". Current Journal of Applied Science and Technology 42, n.º 44 (25 de noviembre de 2023): 13–18. http://dx.doi.org/10.9734/cjast/2023/v42i444279.

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Study was conducted on productive traits in Jersindh crosses. The data were collected from the records of history sheets maintained in Department of Animal Husbandry and Dairying, SHUATS for the period from 1924 to 1973. The productive traits selected from history sheets were first, second and third lactation milk yield and lactation length and dry period. The mean of 1/4J X3/4RS crosses for 1st ,2nd and 3rd LMY (Kg) were 2259.95, 1963.59 and 1832.74 and for lactation length (days) 378.71, 357.78 and 352 and for Dry period (days) 65.94, 98.23 and 98.26, respectively. The mean of 1/2J X 1/2RS crosses for 1st ,2nd and 3rd LMY (Kg) were 1892.14, 1680.14 and 1789.25 and for lactation length (days) 366.06, 338.75 and 359.43 for Dry period (days) 76.81,61 and 59.93 respectively. The mean of 3/8J X 5/8RS crosses for 1st ,2nd and 3rd LMY (Kg) were 1754, 1843.39 and 3682.36 and for lactation length (days) 320.1, 357.15 and 3 and for Dry period (days) 71.2, 70.7 and 72.35 respectively. The mean of 1/8J X 7/8RS crosses for 1st ,2nd and 3rd LMY (Kg) were 1966.35, 1906.51 and 1837.68 and for lactation length (days) 425.6, 371.75 and 446.4, and for Dry period (days) 71.35, 58.75 and 111.2 respectively. Significant effects of season of calving were observed on 3rd LMY of 1/2J X 1/2RS crosses as well as 3/8J X 5/8RS and 2nd LMY of1/4J X 3/4RS crosses , Second and third lactation length of 1/8 X 7/8 crosses has significant influence on lactation milk yield. Second and third lactation length of 1/4 X 3/4 crosses has significant correlation with lactation milk yield and also the regression of milk yield on lactation length was recorded. Third lactation length of 3/8 X 5/8 crosses has significant correlation with lactation milk yield and also the regression of milk yield on lactation length was recorded. Second lactation length of 1/8 X 7/8 crosses has significant correlation with lactation milk yield and also the regression of milk yield on lactation length was recorded. Out of these crosses (1/4Jx3/4RS,1/2JX1/2RS,3/8 JX5/8RS,1/8JX7/8RS) 3/8JX5/8RS has highest lactation length 652.76 and lactation milk yield is 3682.36.
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Ialongo, I., V. Buchard, C. Brogniez, G. R. Casale y A. M. Siani. "Aerosol Single Scattering Albedo retrieval in the UV range: an application to OMI satellite validation". Atmospheric Chemistry and Physics Discussions 9, n.º 5 (14 de septiembre de 2009): 19009–33. http://dx.doi.org/10.5194/acpd-9-19009-2009.

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Abstract. The aerosol Single Scattering Albedo (SSA) and Absorbing Aerosol Optical Depth (AAOD) at 320.1 nm are derived at Rome site by the comparison between Brewer and modelled spectra. The UVSPEC radiative transfer model is used to calculate the UV irradiances for different SSA values, taking into account as input data total ozone and Aerosol Optical Depth (AOD) obtained from Brewer spectral measurements. The accuracy in determining SSA depends on the aerosol amount and on Solar Zenith Angle (SZA) value: SSA uncertainty increases when AOD and SZA decrease. The monthly mean values of SSA and AAOD during the period January 2005–June 2008 are analysed, showing a monthly and seasonal variability. It is found that the SSA and AAOD averages are 0.80±0.08 and 0.056±0.028, respectively. AAOD retrievals are also used to quantify the error in the Ozone Monitoring Instrument (OMI) surface UV products due to absorbing aerosols, not included in the current OMI UV algorithm. OMI and Brewer UV irradiances at 324.1 nm and Erythemal Dose Rates (EDRs) under clear sky conditions, are compared as a function of AAOD. Three methods are considered to investigate on the applicability of an absorbing aerosol correction on OMI UV data at Rome site. Depending on the correction methodology, the bias value decreases from 18% to 2% for spectral irradiance at 324.1 nm and from 25% to 8% for EDR.
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Libros sobre el tema "320.5/8"

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Friedman, Thomas L. Hot, flat, and crowded: Why we need a green revolution and how it can renew America. Waterville, Me: Thorndike Press, 2008.

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Friedman, Thomas L. Hot, flat, and crowded: Why the world needs a green revolution--and how we can renew our global future. London: Allen Lane, 2008.

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Friedman, Thomas L. Hot, flat, and crowded: Why we need a green revolution--and how it can renew America. New York: Picador/Farrar, Straus and Giroux, 2009.

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Friedman, Thomas L. Hot, flat, and crowded: Why we need a green revolution-- and how it can renew America. New York: Farrar, Straus and Giroux, 2008.

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Friedman, Thomas L. Hot, flat, and crowded: Why we need a green revolution-- and how it can renew America. 2a ed. Vancouver: Douglas & McIntyre, 2009.

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Friedman, Thomas L. Hot, flat, and crowded: Why we need a green revolution--and how it can renew America. Detroit: Large Print Press, 2008.

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Friedman, Thomas L. [Hot, flat, and crowded]. Bayrūt: Akādīmiyā Intarnāshyunāl, 2009.

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Friedman, Thomas L. Gurīn kakumei: Ondanka furattoka jinkō kamitsuka suru sekai. Tōkyō: Nihon Keizai Shinbun Shuppansha, 2009.

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Latour, Bruno. Politics of Nature: How to Bring the Sciences into Democracy. Harvard University Press, 2004.

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Latour, Bruno. Politics of Nature: How to Bring the Sciences into Democracy. Harvard University Press, 2004.

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Capítulos de libros sobre el tema "320.5/8"

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Dickens, Charles. "IV, 320.5. to the Marchese Di Negro, 8 June 1845". En The British Academy/The Pilgrim Edition of the Letters of Charles Dickens, Vol. 7: 1853–1855, editado por Kathleen Mary Tillotson, Graham Storey y Angus Easson. Oxford University Press, 1993. http://dx.doi.org/10.1093/oseo/instance.00115326.

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Actas de conferencias sobre el tema "320.5/8"

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Zhou, Wenbo, Gaoxin Bi, Yuhai Wang y Jian Zhao. "Economic Analysis of Online DC-Drive System for Long Distance Heavy-Duty Transport Vehicle Incorporating Multi-Factor Sensitivities". En WCX SAE World Congress Experience. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2024. http://dx.doi.org/10.4271/2024-01-2452.

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<div class="section abstract"><div class="htmlview paragraph">Currently, the rapid expansion of the global road transport industry and the imperative to reduce carbon emissions are propelling the advancement of electrified highways (EH). In order to conduct a comprehensive economic analysis of EH, it is crucial to develop a detailed /8.and comprehensive economic model that takes into account various transportation modes and factors that influence the economy. However, the existing economic models for EH lack comprehensiveness in terms of considering different transportation modes and economic factors. This study aims to fill this gap by designing an economic model for an EH-based Online DC-driven system (ODS) for long distance heavy-duty transport vehicle incorporating multi-factor sensitivities. Firstly, the performance parameters of the key components of the system are calculated using vehicle dynamics equations which involves selecting and matching the relevant components and determining the fundamental cost of vehicle transformation. Secondly, the system economic model is established by considering two operation modes of ODS: integrated operation-construction mode and separated operation-construction mode as well as two transportation scenarios: one-way full load and two-way full load. Finally, the optimal road construction plan for the road is determined, and the sensitivity of the payback period to various parameters is analyzed. The findings of the analysis reveal that the optimal road construction plan entails the construction of 10MW and 14MW traction substations under the one-way full load and two-way full load scenarios, respectively. The estimated investment cost for road construction is 316 million RMB and 320.8 million yuan, respectively. Moreover, ODS exhibits significant improvements in economics for both investors and drivers, resulting in a substantial reduction in the payback period.</div></div>
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