Artículos de revistas: "302.230 966"

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Sánchez, Ignacio. "Lecturas de poesía chilena. De Altazor a La Bandera de Chile. María Inés Zaldivar. Santiago: Ediciones UC, 2019. ISBN: 978-956-14-2480-7. 232 pp." Taller de Letras, n.º 68 (2021): 298–302. http://dx.doi.org/10.7764/tl68298-302.

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Lecturas de poesía chilena. De Altazor a la Bandera de Chile (2020) de María Inés Zaldívar tiene su propia hoja de ruta, traza sus recorridos, se detiene y avanza en un viaje crítico que contempla paradas en escrituras que van desde comienzos del siglo XX hasta el siglo XXI. La autora dibuja su plan de vuelo —lecturas de poesía chilena— y enuncia los medios con los cuales emprenderá su aventura analítica. El viaje altazoriano, que da inicio a las lecturas poéticas, connota la ruta crítica que enmarca el libro, un recorrido que se hace con una mirada que contempla a la viajera como académica y poeta. Esta doble militancia crítica la impulsa a emprender —cual Altazor— un viaje que la impulsa a aterrizar a fin de mirar con ojos propios su visión sobre la poesía chilena: “compartir un conjunto . . . de mis lecturas sobre poesía chilena del siglo XX e inicios del XXI” (9), esto es, aproximaciones, “lecturas posibles” (Bianchi). La estudiosa, por tanto, traza y recorre un “mapa poético alternativo” (10) que desplaza la “mirada analítica literatosa” (185) para detenerse en el placer del texto, como nos diría Barthes, y no en las “teorías de turno” (10). En efecto, Lecturas… es un viaje poético que privilegia el “cuerpo de la voz” de las textualidades (Masiello) para abandonar la “sordera [y así] apreciar todo aquello que no ha calzado con lo que estamos preparados y dispuestos a oír y valorar como poético” (138). Esta declaración explicita una ética crítica, cuyos principios responden a una responsabilidad para con las voces silenciadas en la poesía chilena, principalmente, las mujeres. El libro consta de quince lecturas que se dividen en dos grandes apartados: “Primera Mitad del Siglo XX” (13-115) y “Segunda Mitad del siglo XX” (127-215), las cuales pueden ser leídas de manera individual o en relación. La autora traza su hoja de ruta, mas los lectores pueden decidir desviarse o tomar atajos.

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Obergan, T. Yu, N. F. Myasoedov, M. E. Grigorjeva, L. A. Lyapina, T. A. Shubina y L. A. Andreeva. "Pharmacology complex compound of pro-gly-pro-leu with heparin: hypoglycemic, fibrinolitic and anticoagulant effects in rats with hyperglycemia". Pharmacy & Pharmacology 7, n.º 5 (5 de diciembre de 2019): 300–307. http://dx.doi.org/10.19163/2307-9266-2019-7-5-300-307.

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Andreeva, O. T., N. G. Pilipenko, L. P. Sidorova y N. Yu Kharchenko. "Promising uncommon poaceous and leguminous fodder crops". Siberian Herald of Agricultural Science 50, n.º 4 (25 de septiembre de 2020): 32–39. http://dx.doi.org/10.26898/0370-8799-2020-4-4.

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The results of research (2016-2018) into productivity, adaptability and nutritional value of poaceous crops (forage millet, Sudan grass) and legumes (fodder beans, spring vetch, garden peas) are presented and analyzed. The research was conducted on meadow chernozem mealy-carbonate soil, light loam by granulometric composition, in the forest-steppe zone of Trans-Baikal Territory. Agricultural technology used for fodder crop cultivation was common for this area. The objects of the research were legumes (Sibirskiye forage beans, Novosibirskaya spring vetch, Holik garden peas), and poaceous varieties (Bystroe forage millet, Novosibirskaya 84 Sudan grass). The experimental work was carried out in accordance with the generally accepted guidelines for field experiments. All the forage crops under study have formed a fairly high productivity: the yield of green mass was 13.0-18.2 t/ha, dry matter – 2.6-3.2, feed units – 2.2-2.7 t/ha, digestible protein – 220-567 kg/ha, gross energy – 26.5-32.2 GJ/ha, with availability of digestible protein 100-210 g per one feed unit. Among leguminous crops, spring vetch and fodder beans had an advantage with the green mass yield of 13.3-15.0 t/ha, the amount of dry matter of 3.1-3.2, feed units of 2.6-2.7 t/ha, digestible protein 494–567 kg/ha, gross energy 32.0–32.2 GJ/ha, with availability of digestible protein of 190–210 g per one feed unit. Garden peas were inferior to spring vetch and fodder beans in yield by 2.3-13.3%, dry matter – by 9.6-12.5, feed units – by 3.8-7.4, digestible protein – by 4.9-17.1, gross energy – by 8.1–8.7%. Among poaceous crops, agrocenoses of Sudan grass had an advantage in productivity and nutritional value. They formed the yield of green mass 18.2 t/ha, the amount of dry matter 3.1, feed units 2.5 t/ha, digestible protein 300 kg/ha, gross energy 31.3 GJ/ha, with availability of digestible protein of 120 g per one feed unit. Fodder millet was inferior to Sudan grass in all respects by 12.0–26.7%, respectively.

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Chowdhury, Soumya Ghosh, Koushik Pal, Hirak Satpathi, Abhijit Bandyopadhyay, Rabindra Mukhopadhyay y Sanjay K. Bhattacharyya. "Improving hysteresis of a typical carbon black-filled natural rubber tread compound by using a novel coupling agent". Progress in Rubber, Plastics and Recycling Technology 36, n.º 4 (26 de diciembre de 2019): 245–61. http://dx.doi.org/10.1177/1477760619895015.

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Potential of Sumilink-200 was investigated in a typical natural rubber-based tread compound in connection with its ability to act as a coupling agent for carbon black to reduce hysteresis loss of the compound. Optimum physical properties were obtained at 2 phr loading of Sumilink-200. At this loading, tensile modulus at 300% elongation improved by 9.6% with a reduction in visco-elastic energy dissipation (loss tangent) at 60°C by 8.3% over the control compound. The abrasion resistance properties of the compounds found to remain unaffected with the introduction of Sumilink-200.

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Bigham, J. M., L. Carlson y E. Murad. "Schwertmannite, a new iron oxyhydroxysulphate from Pyhäsalmi, Finland, and other localities". Mineralogical Magazine 58, n.º 393 (diciembre de 1994): 641–48. http://dx.doi.org/10.1180/minmag.1994.058.393.14.

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AbstractSchwertmannite is a new oxyhydroxysulphate of iron from the Pyhäisalmi sulphide mine, Province of Oulu, Finland. It occurs there, and elsewhere, as an ochreous precipitate from acid, sulphate-rich waters. Associated minerals at other localities may include jarosite, natrojarosite, goethite and ferrihydrite. Schwertmannite is a poorly crystalline, yellowish brown mineral with a fibrous morphology under the electron microscope. A high specific surface area in the range of 100 to 200 m2/g, rapid dissolution in cold, 5MHCl or in ammonium oxalate at pH 3, and pronounced X-ray diffraction line broadening are consistent with its poorly crystalline character.Colour parameters for the type specimen as related to CIE illuminant C are L* = 53.85, a* = + 15.93, and b* = +47.96. Chemical analysis gives Fe2O3, 62.6; SO3, 12.7; CO2, 1.5; H2O−, 10.2; H2O+, 12.9; total 99.9 wt.%. These data yield an empirical unit cell formula of Fe16O16(OH)9.6(SO4)3.2·10H2O after exclusion of CO2and H2O−. The most general simplified formula is Fe16O16(OH)y(SO4)z·nH2O, where 16 −y= 2zand 2.0 ⩽z⩽ 3.5. Schwertmannite has a structure akin to that of akaganéite (nominally β-FeOOH) with a doubledcdimension. Its X-ray powder diffraction pattern consists of eight broad peaks [dobsin (Iobs) (hkl)] 4.86(37)(200,111); 3.39(46)(310); 2.55(100)(212); 2.28(23)(302); 1.95(12)(412); 1.66(21)(522); 1.51(24)(004); and 1.46(18)(204,542), givinga= 10.66(4),c= 6.04(1) Å, andV= 686(6) Å3for a primitive, tetragonal unit cell. The probable space group isP4/m. Upon heating, schwertmannite transforms to hematite with Fe2(SO4)3occurring as an intermediate phase. Bidentate bridging complexes between Fe and SO4are apparent in infrared spectra. Mössbauer data show the Fe in schwertmannite to be exclusively trivalent and in octahedral coordination; it has a Néel temperature of 75 ± 5 K and a saturation magnetic hyperfine field of about 45.6 T. Pronounced asymmetry of the Mössbauer spectra indicates different locations for Fe atoms relative to SO4groups in the structure. The name is for Udo Schwertmann, professor of soil science at the Technical University of Munich.

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Hamano, Akiei, Mamoru Umeda, Yukiko Ueno, Seiji Tanaka, Jun Mimuro y Yoichi Sakata. "Latex Immunoturbidimetric Assay for Soluble Fibrin Complex". Clinical Chemistry 51, n.º 1 (1 de enero de 2005): 183–88. http://dx.doi.org/10.1373/clinchem.2004.040360.

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Abstract Background: Soluble fibrin complex (SFC), composed of fibrin monomer and fibrinogen derivatives, is known to exist in the circulating blood in patients with thrombosis. Its detection and quantification are useful for obtaining information about the condition and degree of intravascular coagulation in early-stage thrombosis, but there is no rapid method to measure SFC in plasma for clinical use. Methods: We obtained a monoclonal antibody that specifically reacts with SFC, with desAA-fibrin as the immunogen, and developed a rapid and sensitive latex immunoturbidimetric assay (LIA) using latex-immobilized anti-SFC monoclonal antibody. The assay system was based on the increase in turbidity induced by the reaction of the latex-immobilized anti-SFC monoclonal antibody with SFC in plasma, and the assay procedure was fully automated on a Hitachi 911 analyzer. Results: The method had an analytical range of 3–300 mg/L. Intra- and interassay precision studies indicated that this system provided reproducible data (CVs <3.0% and <2.0%, respectively). The assay detection limit was <0.5 mg/L. There was no interference from bilirubin (up to 440 mg/L), hemoglobin (up to 9.6 g/L), Intralipid (up to 10%), D-dimer (up to 200 mg/L), and rheumatoid factor (up to 470 000 IU/L). SFC concentrations in plasma from patients with thrombotic diseases [mean (SD), 48.9 (57.6) mg/L; n = 160) were significantly higher than those in plasma from healthy individuals [1.8 (2.1) mg/L; P <0.001; n = 304]. Conclusion: In terms of linearity, precision, and sensitivity, the LIA, performed on a Hitachi 911 automated analyzer, may be useful for measurement of SFC in plasma.

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Chen, Henian, Yuanyuan Lu y Nicole Slye. "Testing for baseline differences in clinical trials". International Journal of Clinical Trials 7, n.º 2 (22 de abril de 2020): 150. http://dx.doi.org/10.18203/2349-3259.ijct20201720.

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<p class="abstract">Reporting statistical tests for baseline measures of clinical trials does not make sense since the statistical significance is dependent on sample size, as a large trial can find significance in the same difference that a small trial did not find to be statistically significant. We use 3 published trials using the same baseline measures to provide the relationship between trial sample size and p value. For trial 1 sequential organ failure assessment (SOFA) score, p=0.01, 10.4±3.4 vs. 9.6±3.2, difference=0.8; p=0.007 for vasopressors, 83.0% vs. 72.6%. Trial 2 has SOFA score 11±3 vs. 12±3, difference=1, p=0.42. Trial 3 has vasopressors 73% vs. 83%, p=0.21. Based on trial 2, supine group has a mean of 12 and an SD of 3 for SOFA score, while prone group has a mean of 11 and an SD of 3 for SOFA score. The p values are 0.29850, 0.09877, 0.01940, 0.00094, 0.00005, and <0.00001 when n (per arm) is 20, 50, 100, 200, 300 and 400, respectively. Based on trial 3 information, the vasopressors percentages are 73.0% in the supine group vs. 83.0% in the prone group. The p values are 0.4452, 0.2274, 0.0878, 0.0158, 0.0031, and 0.0006 when n (per arm) is 20, 50, 100, 200, 300 and 400, respectively. Small trials provide larger p values than big trials for the same baseline differences. We cannot define the imbalance in baseline measures only based on these p values. There is no statistical basis for advocating the baseline difference tests</p>

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Kuzhuget, Renat V., Natalia N. Ankusheva, Ailai K. Hertek, Yuri A. Kalinin, Bulat B. Damdinov, Franco Pirajno, Yuri V. Butanaev, Nadezhda V. Suge-Maadyr y Sholban N. Soldup. "Precious-Metal Mineralization and Formation Conditions of the Biche-Kadyr-Oos Epithermal Au-Ag Ore Occurrence (Eastern Sayan, Russia)". Minerals 13, n.º 12 (8 de diciembre de 2023): 1529. http://dx.doi.org/10.3390/min13121529.

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The Biche-Kadyr-Oos epithermal Au-Ag ore occurrence is a prospective object in the Ak-Sug porphyry copper ore cluster (Eastern Sayan) in the northern part of the Central Asian orogenic belt (CAOB). The mineralization consists of gold-sulfide-quartz and gold-polysulfide-carbonate-quartz veins with argillic zones in the Lower Cambrian volcanic-sedimentary rocks. The origin of the Au-Ag ore occurrence is still debatable. To determine the origin, we examined the mineralogical and geochemical features, conditions of formation, and fluid sources of the Biche-Kadyr-Oos ore. A mineralogical and geochemical investigation outlines three stages of mineral formation: early argillic stage; gold-sulfide-quartz stage with pyrite, marcasite, pyrrhotite, arsenopyrite, chalcopyrite, less frequently sphalerite, hessite, gold, and electrum; and late gold-polysulfide-carbonate-quartz stage with gold, electrum, Hg-electrum, Se-acanthite, Se-galena, bornite, tennantite, tetrahedrite, hessite, tellurobismuthite, bismuthinite, matildite, jamesonite, ourayite, native Bi, and barite. Fluid inclusion study (thermometry, Raman spectroscopy) in quartz and mineral thermometry (electrum and sphalerite paragenesis) determined that ore veins were formed at P~0.5 kbar from CO2-water Na-K-chloride fluid (4.9–9.6 wt % NaCl eqv) and temperatures from 300 to 200 °C (early gold-sulfide-quartz veins at 300–230 °C, and late gold-polysulfide-carbonate-quartz veins at 290–200 °C) and variations in fO2, fS2, fSe2 and fTe2. The S isotopic composition in sulfides and δ34SH2S values of the fluid are +1.3‰ and +4.7‰, respectively, (T = 300–275 °C) indicating magmatic S in ore formation. The oxygen isotope data indicate that during the formation of veins, the magmatic fluid mixed with meteoric water (δ18Ofluid is from +3.4 to +6.4‰). The isotopic data that were obtained combined with mineralogical and geochemical features and conditions of ore formation indicate the similarity of Biche-Kadyr-Oos ore occurrence with epithermal Au-Ag deposits of intermediate sulfidation (IS) type. The presence of epithermal Au-Ag mineralization of the Biche-Kadyr-Oos IS type in ore cluster of the Ak-Sug Cu-Au-Mo porphyry deposit indicates the existence of a single porphyry-epithermal ore-magmatic system.

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ШЕМЕТ, В. Я. y О. І. ГУЛАЙ. "ХАРЧОВІ ДОБАВКИ НАТУРАЛЬНОГО ПОХОДЖЕННЯ: КОРОТКИЙ ОГЛЯД". Товарознавчий вісник 1, n.º 16 (7 de marzo de 2023): 6–18. http://dx.doi.org/10.36910/6775-2310-5283-2023-17-1.

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Мета. Аналіз харчових добавок натурального походження, які мають позитивний вплив на організм людини. Методика. Методологічною базою роботи стали наукові доробки українських та іноземних фахівців у галузі виробництва та аналізу харчових добавок. Враховуючи те, що харчування є однією з найголовніших потреб людини, автори основну увагу звертають на добавки натурального походження, які мають позитивний вплив на організм. При написанні статті були використані такі методи дослідження, як логічне узагальнення, системний підхід та теоретичний пошук, що ґрунтуються на пошуку та обробці наукової інформації. Результати. Якісна їжа є постачальником енергії для розвитку та життєдіяльності організму, сприяє підтриманню здоров’я в належному стані, підвищує працездатність людини та її самопочуття. Головним критерієм використання харчових добавок повинна бути їх безпечність, і навіть при тривалому зберіганні та споживанні вони не повинні загрожувати здоров’ю людини. Охарактеризовано харчові добавки натурального походження, які позитивно впливають на організм людини. Такий ефект здійснюють натуральні пігменти куркумін Е 100, хлорофіл Е 140, каротин Е 160, органічні кислоти – сорбінова E 200, яблучна Е 296, аскорбінова Е 300, жироподібні речовини (альфа-токоферол Е 307), вуглеводи та їх похідні (пектин Е 440, целюлоза Е 460, глюконат заліза (Е 579), багатоатомні спирти мальтит E 965, ксиліт Е 967, солі амінокислот та білки (глутамат натрію Е 621, колаген Е 1020). Використання таких речовин на противагу токсичним сполукам є важливим аспектом дотримання принципів харчової безпеки. Встановлено, що серед харчових добавок натурального походження найбільше природних барвників, які отримують з рослин, тварин, мікроорганізмів, мінералів тощо. Практична значимість. Робота має різнобічне спрямування й представляє науковий інтерес не лише для науковців, магістрів й спеціалістів галузі товарознавства продовольчих товарів, технології харчування, гігієни харчування, біології, медицини, а також розрахована на широке коло фахівців, що працюють у суміжних й дотичних, до вищенаведених, галузях народного господарства України. Матеріал також може бути цікавим для пересічних споживачів, що опікуються власним здоров’ям та цікавляться інноваціями у товарознавстві. Отримані результати можуть бути використані для аналізу та дослідження вмісту харчових добавок.

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Pankrats, Anatolii, Alexander Vorotynov, Vasilii Tugarinov, Sergey Zharkov, Galina Abramova, Galina Zeer, Karthik Ramasamy y Arunava Gupta. "Magnetic Resonance in CuCr₂S₄ Nanoclusters and Nanocrystals". Solid State Phenomena 233-234 (julio de 2015): 542–45. http://dx.doi.org/10.4028/www.scientific.net/ssp.233-234.542.

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Nanoclusters and nanocrystals of the room temperature magnetic spinel CuCr2S4 synthesized using a facile solution-based method were examined by magnetic resonance in a wide frequency range 9.6÷80 GHz and at temperatures down to 4.2 K. Decreasing of the resonance field and broadening of the resonance lines are found below ∼ 50 K for both the nanocluster and nanocube samples due to the freezing of magnetic moments of nanocubes and nanocrystalline particles constituting nanoclusters. Additional blocking temperature Tb≅300 K appears in nanoclusters due to the freezing of the magnetic moment of the entire cluster as a whole. Below this temperature, an additional low-field resonance line is found in the resonance spectra of nanoclusters at X-band.

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Chien-Hsiang Ni, Yun-Xuan Chang, Tsung-Han Wu, Ya-Peng Wang, Chia-Chi Chen, Tzu-Yun Chi, Yen-Jung Lu et al. "Evaluation of genotoxicity of dry powders of pomelo (Citrus maxima) flowers by micronucleus assay". International Journal of Scholarly Research in Life Sciences 2, n.º 1 (30 de septiembre de 2023): 014–21. http://dx.doi.org/10.56781/ijsrls.2023.2.1.0031.

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Plants have been used as traditional medicine or health products for several thousands of years. The present study was aimed to evaluate the genotoxicity of pomelo flower powders by micronucleus assay In vivo. During the In vivo genotoxicity-evaluated experiment, the experimental animal’s clinical behavior, body weight (BW), food consumption, and the percentage of RET/RBCs (reticulocytes/red blood cells) and MN-RET/RETs (micronucleated reticulocytes/reticulocytes) after the treatments of pomelo (Citrus maxima) flower powders were evaluated. Both sexes ICR mice were treated three daily treatments by intraperitoneal injection of 2 mg/kg of mitomycin C (genotoxicity induction) or by oral route of 200 μL of PBS (the normal control group). Until 30th hours after the last treatment, K2-EDTA-anticoagulated peripheral blood specimens were collected. These blood samples were processed for the microscopy-based analysis using Giemsa stain and the percentage of reticulocytes and micronucleated reticulocytes was determined. The results were shown that the experimental animal’s clinical behaviors were normal in all groups. The BW and food consumption were no significant difference between all groups. RET/RBCs (%) in male or female ICR mice in the negative control group, the normal control group, the low dose of pomelo (C. maxima) flower powder group, the middle dose of pomelo (C. maxima) flower powder group, and the high dose of pomelo (C. maxima) flower powder group were respectively 8.8 ± 2.3 / 9.6 ± 2.6, 23.0 ± 2.5 / 22.4 ± 2.3, 23.4 ± 2.1 / 23.2 ± 3.8, 24.2 ± 3.6 / 23.0 ± 1.9, and 21.6 ± 3.2 / 21.6 ± 2.4; MN-RET/RETs (‰) in male or female ICR mice in the negative control group, the normal control group, the low dose of pomelo (C. maxima) flower powders group, the middle dose of pomelo (C. maxima) flower powder group, and the high dose of pomelo (C. maxima) flower powder group were 43.0 ± 12.5 / 39.4 ± 9.8, 2.6 ± 1.5 / 2.6 ± 1.5, 2.4 ± 1.1 / 2.2 ± 1.3, 2.2 ± 1.3 / 2.0 ± 1.2, and 1.8 ± 0.8 / 1.8 ± 0.8, respectively. Both RET/RBCs (%) and MN-RET/RETs (%) in male or female ICR mice in the negative control group were significantly difference than the other groups (p < 0.001). Taken all results together, pomelo (C. maxima) flower powders were without genotoxicity. Therefore, pomelo (C. maxima) flower powders were safety.

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Knight, K. S., C. N. W. Darlington y I. G. Wood. "The crystal structure of KCaF3 at 4.2 and 300 K: A re-evaluation using high-resolution powder neutron diffraction". Powder Diffraction 20, n.º 1 (marzo de 2005): 7–13. http://dx.doi.org/10.1154/1.1835959.

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The crystal structure of the perovskite phase KCaF3 has been redetermined at 4.2 and 300 K using powder neutron diffraction collected at the highest resolution. At both temperatures the phase was found to be orthorhombic in space group Pnma, with lattice parameters a=0.622 879(5) nm, b=0.870 031(7) nm, c=0.611 210(5) nm at 4.2 K, and a=0.621 488(6) nm, b=0.876 360(8) nm, c=0.616 481(6) nm at 300 K. The CaF6 octahedron is regular at both temperatures with octahedral rotations of 9.6° and 13.2° for the in-phase and anti-phase tilts, respectively, at 4.2 K. No evidence was found to support the recent revision of the space group from Pnma to the monoclinic space group B21∕m.

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Hotta, Masatoshi, Johannes Czernin, Andrei Gafita y Jeremie Calais. "Outcome of patients with PSMA PET/CT screen failure by VISION criteria and treated with 177Lu-PSMA therapy: A multicenter retrospective analysis." Journal of Clinical Oncology 40, n.º 16_suppl (1 de junio de 2022): 5042. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.5042.

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5042 Background: The VISION trial showed that 177Lu-PSMA prolongs survival and improves the quality of life of patients with advanced mCRPC. It used PSMA-PET/CT to select patients for inclusion. The screen failure rate was “only” 12.6% (126/1003) and some have argued that the trial could have been positive even in an unselected population. It remains unknown whether the VISION-PET criteria were appropriate to stratify patients into likely responders versus non-responders to177Lu-PSMA. Here, we evaluated the outcome of patients who would have been excluded by the VISION-PET criteria and were nevertheless treated with 177Lu-PSMA. Methods: Patients treated with ≥1 cycle of 177Lu-PSMA between 11/2017 and 07/2021 (n = 74) who were registered in our institutional database and those enrolled in a multicenter dataset published previously (n = 230) (Gafita A, Lancet Oncol 2021) were retrospectively studied. One dual certified nuclear medicine and radiology reader reviewed baseline PSMA PET/CT studies and classified the patients as eligible (VISION-PET-E) or screen failure (VISION-PET-SF) based on the VISION-PET criteria: 1) absence of metastatic lesion(s) with uptake > liver background (i.e., low PSMA expression) or 2) presence of ≥ 1 metastatic lesion measurable by CT (≥ 1 cm for bone lesions with soft-tissue component (M1b) and solid/visceral organs lesions (M1c); ≥ 2.5 cm for lymph nodes lesions (N1-M1a)) with uptake ≤ liver background (i.e., PSMA-negative lesions). Outcome measures were PSA response rates (decline of ≥50% (PSA50RR), any decline (anyPSARR)), PSA-progression free-survival (PSA-PFS), and overall survival (OS). Results: 3/304 patients (1%) were excluded (lost to follow-up (n = 2), missing CT data (n = 1)). The median follow-up time was 22.5 (range: 2.1-62.3) months. 272/301 (90.4%) were VISION-PET-E, while 29/301 (9.6%) were VISION-PET-SF: 8/301 (2.7%) and 21/301 (7.0%) patients with low PSMA expression and PSMA-negative lesions, respectively. The VISION-PET-SF patients had worse PSA50RR (21% vs 50%; p = 0.005), anyPSARR (41% vs 71%; p = 0.003), median PSA PFS (2.1 months (95%CI: 1.1-3.3) vs. 4.1 (4.0-5.8); p = 0.023)), and tended to have a shorter OS (9.6 months (95%CI: 4.7-14.0) vs. 14.2 (12.6-15.9); p = 0.16) than the VISION-PET-E patients. Conclusions: VISION-PET-SF patients had worse outcomes than the VISION-PET-E patients. Our cohort only included patients who were eligible by each local site criteria. It did not include those 10-15% of patients who were excluded by local site assessment. Thus, 20-25% of the patients may be screen failures in unselected populations. Refinements in patient selection for 177Lu-PSMA are needed to optimize outcomes. Not characterizing target expression prior to PSMA-targeted treatment appears now non-ethical as a predictive whole-body imaging biomarker for response to PSMA-targeted therapies is available.

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Hotta, Masatoshi, Andrei Gafita, Johannes Czernin y Jeremie Calais. "Outcome of patients with PSMA-PET/CT screen failure by VISION criteria and treated with 177Lu-PSMA therapy." Journal of Clinical Oncology 40, n.º 6_suppl (20 de febrero de 2022): 39. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.039.

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39 Background: The VISION trial showed that 177Lu-PSMA can prolong survival and improve the quality of life of patients with advanced mCRPC. The VISION trial used PSMA-PET/CT to select patients for inclusion. Here, we evaluated the outcome of patients treated with 177Lu-PSMA who would have been screen failure (SF) by VISION-PET criteria. Methods: We conducted a retrospective cohort study in our institutional database of patients treated with ≥1 cycle of 177LuPSMA between November 2017 and July 2021 (n = 74) and a multicenter dataset published previously (n = 230) (Gafita A, Lancet Oncol 2021). One dual certified reader (M.H.) in nuclear medicine and radiology blinded for patient outcomes reviewed the baseline PSMA-PET/CT scans to define eligible (VISION-PET-E) vs SF (VISION-PET-SF) patients. VISION-PET- SF criteria were defined as:1) absence of metastatic lesion with uptake > liver background (i.e., low PSMA expression) or 2) presence of ≥ 1 metastatic lesion measurable by CT (≥ 1 cm for bone lesions with soft-tissue component (M1b) and solid/visceral organs lesions (M1c); ≥ 2.5 cm for lymph nodes lesions (N1-M1a)) with uptake ≤ liver background (i.e., PSMA-negative lesions). Outcome measures included PSA response rates (decline of ≥50% (PSA50RR) and any decline (anyPSARR)), PSA-progression free-survival (PSA-PFS), and overall survival (OS). Results: 3/304 patients (1%) were excluded (lost to follow-up (n = 2), missing DICOM CT images (n = 1)). 272/301 (90.4%) of the analyzed patients were VISION-PET-E while 29/301 (9.6%) were VISION-PET-SF: 8/301 (2.7%) with low PSMA expression and 21/301 (7.0%) with PSMA-negative lesions, respectively. The median follow-up time was 12.6 months (IQR: 7.0-21.3, range: 0.6-62.3). VISION-PET-SF patients had a worse PSA50RR (21% vs 50%; p = 0.005), anyPSARR (41% vs 71%; p = 0.003), median PSA PFS (2.1 months (1.1-3.3) vs. 4.1 (4.0-5.8); p = 0.023)), and tended to have a shorter median OS (9.6 months (4.7-14.0) vs. 14.2 (12.6-15.9); p = 0.16) than the VISION-PET-E patients. Patients with PSMA-negative lesion (n = 21) tended to have a worse response than those with low PSMA expression (n = 8): median OS 8.2 months (4.4-11.0) vs. NA (11.1-NA) (p = 0.034), median PSA-PFS 1.8 months (1.4-3.3) vs. 2.8 (1.1-5.7) (p = 0.44), PSA50RR 19% vs 25% (p = 1.00), and any PSARR 38% vs 50% (p = 0.68). Conclusions: Some have argued that the low SF rate of 12.6% (126/1003) in the VISION trial may obviate the need for PSMA-PET eligibility screening prior to 177Lu-PSMA. Here we report that VISION-PET-SF patients had worse outcomes than VISION-PET-E patients in response to 177Lu-PSMA therapy. The best management of patients with negative or low PSMA expressing lesions is unknown. Combining 177Lu-PSMA with external-beam RT and/or with other systemic therapy may be an effective therapeutic approach. Refinements in patient selection for 177Lu-PSMA are needed to optimize patient outcomes.

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Freitas, R. S., P. C. Pereira, M. A. N. Sediyama, F. A. Ferreira y T. Sediyama. "Seletividade de herbicidas aplicados em pós-emergência para a cultura da mandioquinha-salsa". Planta Daninha 22, n.º 1 (marzo de 2004): 159–65. http://dx.doi.org/10.1590/s0100-83582004000100020.

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A suscetibilidade da cultura de mandioquinha-salsa a herbicidas aplicados em pós-emergência foi avaliada, cultivando-se três mudas pré-enraizadas e uniformes por vaso de cinco litros de capacidade, preenchidos com solo Podzólico Vermelho-Amarelo Câmbico, fase terraço, coletado na camada de 0-20 cm. Utilizou-se o delineamento de blocos ao acaso, com três repetições e 39 tratamentos obtidos do arranjo fatorial (13 x 3), sendo 12 herbicidas e uma testemunha sem herbicida e três doses (uma dose baixa, uma média e uma alta). As doses dos herbicidas (em g ha-1) foram: bentazon (600, 720 e 960), clethodim (84, 96 e 108), fenoxaprop-p-ethyl (68, 90 e 110), flazasulfuron (50, 75, 100), fluazifop-p-butil (94, 187 e 250), halosulfuron (75, 112 e 150), imazamox (28, 35 e 42), linuron (900, 1.350 e 1.800), oxadiazon (500, 750 e 1.000), propaquizafop (100, 125 e 150), sethoxydim (184, 230 e 276) e amônio-glufosinato (200, 300 e 400). A colheita das plantas foi realizada aos 49 dias após a aplicação dos tratamentos (DAA). Os herbicidas halosulfuron, flazasulfuron, imazamox e bentazon causaram alta toxicidade e prejuízos para as características avaliadas, sendo considerados não-seletivos para a cultura. O linuron e oxadiazon, nas doses baixa e média, e o amônio-glufosinato, na dose baixa, proporcionaram toxicidade às plantas de mandioquinha-salsa no início das avaliações, porém observou-se boa recuperação a partir de 28 DAA. O fluazifop-p-butil foi seletivo nas menores doses utilizadas. Os herbicidas clethodim, fenoxaprop-p-ethyl, propaquizafop e sethoxydim foram os mais seletivos.

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K., Shilpa S., Sadia Moin y Naima Fatima. "Nuchal cord: from dread towards confident management". International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, n.º 5 (28 de abril de 2020): 1820. http://dx.doi.org/10.18203/2320-1770.ijrcog20201566.

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Background: This study was aimed at observing the outcomes of pregnancies with sonographically detected nuchal cord or cord around the neck at term. Early studies on nuchal cord showed many maternal and neonatal complications. But several recent studies have suggested that maternal and neonatal complications do not increase with nuchal cord at delivery. This ambiguity increases anxiety in treating obstetricians and relatives of pregnant women, thus leading to unnecessary caesarean sections. This study is intended to observe the maternal and neonatal outcomes of 300 pregnant women with sonographically detected nuchal cord at term.Methods: Prospective observational study where 300 term pregnant women with sonographically detected nuchal cord were observed through delivery at Shri Venkata Sai Medical College, Mahabubnagar, Telangana, during October 2016 to April 2018.Results: In this study 80.6% women had normal vaginal delivery, 8.3% had LSCS, 11% had instrumental deliveries. 54% had loose nuchal cord, 46% had tight loop of cord.60% had normal CTG, 8% had variable deceleration, 2% late deceleration. Neonatal morbidity was 9.6% and zero neonatal mortality.Conclusions: The study concluded that the presence of nuchal cord does not adversely affect the mother and the neonate. Presence of nuchal cord per se is not an indication for LSCS. Effect of nuchal cord on neonate is only transient. These women can be allowed for vaginal delivery with routine labour room protocols. Routine sonographycal detection of nuchal cord is not required and if it is reported, it should not dictate obstetric management.

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Urbanchik, E. A., V. A. Kurkin, E. N. Zaitseva, V. M. Ryzhov, A. V. Dubishchev, A. S. Tsybina, A. I. Altareva y Yu D. Sirotkina. "Phytochemical and pharmacological study of biologically active compounds and dry extracts of Populus rubrinervis Hort. Alb. buds of various polarities". Pharmacy & Pharmacology 11, n.º 4 (9 de enero de 2024): 301–11. http://dx.doi.org/10.19163/2307-9266-2023-11-4-301-311.

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The aim of the work was a phytochemical and pharmacological study of biologically active compounds (BACs) and Populus rubrinervis Hort. Alb. buds preparations of various polarities.Materials and methods. The object of the study was dry extracts of P. rubrinervis Hort. Alb. buds the samples of which were prepared in January–March 2023 in the Botanical Garden of Samara University (Samara, Russia). The separation of the amount of current substances was carried consecutively by the method of circulating extraction (chloroform), then, by the method of fractional percolation, a tincture was received on 70% ethyl alcohol (1:5). Pinostrobin was used as the standard sample (SS). The analysis of the substances was carried out by the TLC method. The electronic spectra registration was carried out with a spectrophotometer “Specord 40” (Analytik Jena, Germany). The study of the pharmacological (diuretic) activity of P. rubrinervis Hort. Alb. buds dried extracts was carried out on 60 white outbred rats of both sexes weighing 200–220 g in the experiments with aqueous diuresis.Results. P. rubrinervis Hort. Alb. buds dried extracts of various polarities (extract No. 1 (chloroform) and extract No. 2 (70% ethanol) were received. By the method of thin-layer chromatography, it was determined that the dominant complexes of the lipophilic nature with pinostrobin are isolated in extract No. 1, phenolic substances of the glycoside nature prevail in extract No. 2. Despite various polarities of the extragents, spectral characteristics of extract No. 2 have significant similarities with extract No. 1. When studying the diuretic activity, it was established that when SS pinostrobin was injected at a dose of 1 mg/kg, for 4 h of the experiment, an isolated increase in diuresis was noted (from 1.72±0.11 to 1.97±0.03 ml, p <0.05); at the same time, an isolated increase in creatininuresis (from 1.50±0.29 to 2.39±0.15 mg, p <0.05) was observed during 24 h of the experiment. When extract No. 2 was injected at a dose of 10 mg/kg, there was a moderate significant increase in diuresis (from 1.82±0.02 to 2.07±0.04 ml and from 2.38±0.39 to 3.02±0.11 ml, p <0.05) and a significant increase in creatininuresis (from 0.14±0.01 to 0.19±0.03 mg and from 2.31±0.42 to 2.79±0.51 mg, p <0.05) for 4 and 24 h of the experiment, respectively.Conclusion. The extraction separation of the amount of P. rubrinervis Hort. Alb. buds by the polarity degree was carried out. Pinostrobin SS at a dose of 1 mg/kg and extract No. 2 at a dose of 10 mg/kg had a diuretic activity, in connection with which they are promising in terms of the development of effective drugs.

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Shen, Qijun. "A Fine Forgery: The Yellow Court Classic Revisited". Communications in Humanities Research 3, n.º 1 (17 de mayo de 2023): 843–50. http://dx.doi.org/10.54254/2753-7064/3/20221029.

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Questions arising from the authorship of the Yellow Court Classic have confronted art historians since the Northern Song dynasty (960-1127): who produced it; what is the authentic work of Wang Xizhi (303-361); what are the forgeries? With a focus on the so-called Xin Tai Ping version, once collected by Zhao Mengfu (1254-1322) and now held by the Gotoh Museum in Tokyo, this paper argues that it is a fine forgery among the multiple versions of the Yellow Court Classic. Through a close reading of the colophons, I attempt to map out the collecting history of the XTP version and why it was prized by connoisseurs over the centuries. I then compare it with the other two versions and Zhou You's (151-230) work, primarily in terms of calligraphic style, to further demonstrate why the XTP version is the best and the closest version to the work of Wang Xizhi.

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Kirei, Anggita Ananda y Rena Widita. "Analysis of the Effect of Tube Current, Slice Thickness, and Tube Voltage on Ct Scan Image Noise using the Noise Power Spectrum (NPS) Method". Indonesian Journal of Physics 34, n.º 2 (4 de enero de 2024): 14–19. http://dx.doi.org/10.5614/itb.ijp.2023.34.2.3.

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This study was conducted to analyze CT scan images in order to determine the effect of tube current, slice thickness, and tube voltage on noise using the Noise Power Spectrum (NPS) method. Moreover, this study was also aimed to identify the optimal range of tube current, slice thickness, and tube voltage values to minimize noise formation in CT scan images while maintaining the safe dose for the patients. The research parameters included variations in tube current values with slice thickness variations, using tube voltages of 80 kV and 120 kV. The tube current (mAs) variations used were 150 mAs, 200 mAs, 250 mAs, 300 mAs, and 350 mAs, while the slice thickness variations were 0.8 mm, 1.6 mm, 3.2 mm, 4.8 mm, and 9.6 mm. A Phillips 16-slice access CT scan with a water phantom was utilized as the material for the research. The obtained image data were analyzed using ImQuest and ImageJ software. The results show that as the variations in tube current (mAs), slice thickness (mm), and tube voltage (mV) increase, the noise values decrease. This was demonstrated by the smallest area under the curve (AUC) values, which were 24.46 variance for the tube current variation at 120 kV and 3.57 variance for the slice thickness variation at 120 kV. Thus, to minimize the noise, it is recommended to increase the tube current, slice thickness, and tube voltage.

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Kurtoğlu, MG, H. Bozkurt, O. Tuncer, R. Kesli y M. Berktas. "Distribution, Optimum Detection Time and Antimicrobial Susceptibility Rates of the Microorganisms Isolated from Blood Cultures over a 4-Year Time Period in a Turkish University Hospital and a Review of the International Literature". Journal of International Medical Research 36, n.º 6 (diciembre de 2008): 1261–72. http://dx.doi.org/10.1177/147323000803600613.

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This study retrospectively examined 8986 blood cultures from patients over a 4-year time period in an eastern Turkish university hospital to determine the detection times and distribution of isolated microorganisms using the automated BACTEC™ 9050 and BACTEC™ 9120 systems. A total of 1914 (21.3%) blood cultures contained pathogenic microorganisms and 252 (2.8%) positive cultures were considered contaminated. Of all the cultures, 18 (0.2%) were false positives and 224 (2.5%) were false negatives. In cultures containing pathogenic microorganisms, Gram-positive and Gram-negative bacterial isolation rates were 436 (22.8%) and 1440 (75.2%), respectively, and yeasts (all Candida sp.) were found in 38 (2.0%) cultures. Coagulase-negative staphylococci occurred in 936 (48.9%) cultures and Staphylococcus aureus occurred in 302 (15.8%) cultures. The mean detection time for all of the pathogens was 21 h and Brucella spp were isolated within 10 days. This study helps in understanding the epidemiology of the region and in providing positive therapeutic approaches. A review of the international literature helps to place this understanding into a global context.

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Mathe, Priyanka, Suniti Kale, Aruna Batra, Achla Batra, Shipra Aggrawal y Abhishek Nagarajappa. "Intravenous oxytocin bolus and infusion versus infusion alone on the blood loss during caesarean section". International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, n.º 12 (26 de noviembre de 2019): 4824. http://dx.doi.org/10.18203/2320-1770.ijrcog20195328.

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Background: PPH is one of the leading causes of maternal mortality in the world. In India >30% maternal mortality is because of PPH.Methods: 250 females posted for LSCS were randomised into 2 groups. Group A: 5U oxytocin bolus + 40U oxytocin infusion @125 ml/hour in 500 ml saline. Group B: 5 ml Saline bolus + 40 U oxytocin infusionPrimary outcome was to measure blood loss (objective and subjective). Secondary outcomes were time for uterine hardening, additional uterotonic agents, hemodynamic changes, side effects and need for blood transfusion within 24 hours of LSCS.Results: Blood loss was significantly less in Group A in objective as well as subjective assessment (p<0.001). Requirement for additional oxytocin bolus was significantly higher in Group B as compared Group A (p=0.025). Postoperative hematocrit of Group A was higher than that of Group B (p<0.001). Transfusion requirement was significantly higher (p=0.04) in Group B (9.6% versus 3.2%). There was no significant difference in hemodynamics between the groups in the intraoperative period (p>0.05). However, during the postoperative period increase in heart rate was noted in Group B (p<0.05). Vomiting was the only major side effect observed, which was higher in Group A (5.6% versus 3.2%).Conclusions: Combination of 5U oxytocin bolus followed by an infusion of 40 U oxytocin given over 4 hours routinely in ASA grade I and ASA grade II parturient significantly decreases the operative blood loss during LSCS without causing any hemodynamic variability. This regimen provides better uterine contractility, lesser need for additional utero-tonic agents and lesser requirement of blood transfusion.

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Balykova, L. A., N. M. Selezneva, E. I. Gorshenina, O. I. Shepeleva, N. V. Kirichenko, E. N. Simakina, K. B. Kolontarev et al. "MODERN DIRECTED ANTIVIRAL COVID-19 THERAPY: RESULTS OF MULTICENTER CLINICAL EFFECTIVENESS AND SAFETY STUDY OF FIXED NIRMATRELVIR+RITONAVIR COMBINATION". Pharmacy & Pharmacology 10, n.º 4 (30 de octubre de 2022): 371–86. http://dx.doi.org/10.19163/2307-9266-2022-10-4-371-386.

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The article presents the data from an open, two-stage, multicenter study on the efficacy and safety evaluation of a combined drug (a fixed combination of nirmatrelvir 300 mg and ritonavir 100 mg) in the complex therapy in COVID-19 patients.The aim of the study was to assess the safety, tolerability and pharmacokinetic parameters of the fixed combination of nirmatrelvir 300 mg and ritonavir 100 mg in healthy volunteers, the efficacy and safety assessment of the drug in the combination therapy compared with the standard therapy in COVID-19 patients.Material and methods. An open two-stage multicenter clinical study to assess the main pharmacokinetic parameters, safety, and efficacy against COVID-19 of the drug nirmatrelvir 300 mg and ritonavir 100 mg combination (Skyvira® PROMOMED RUS LLC, Russia) in the adult population, included 2 stages. At stage 1, safety, tolerability and pharmacokinetic parameters were evaluated in healthy volunteers (over 18 years of age) in order to confirm their comparability with the literature data known for a set of active substances. Phase 2 assessed efficacy and safety in COVID-19 patients. As a part of the second stage, the study involved 264 patients (men and women aged 18 to 80 years), who had been divided into two groups. The first group patients (n=132) received the study drugs (nirmatrelvir 300 mg and ritonavir 100 mg) – 1 tablet twice a day with an interval of 12±2 hours for 5 days in combination with pathogenetic and symptomatic therapy. The second group patients (n=132) received standard therapy in accordance with the approved Temporary Guidelines for the Prevention and Treatment of Novel Coronavirus Infection (Version 15 dated February 22, 2022).Results. During the study, none of the patients from the (nirmatrelvir + ritonavir) group experienced a transition of the COVID-19 course to a heavier severity level, in contrast to the patients in the standard therapy group. The study participants included patients with comorbidities (68% of the general population), with risk factors for COVID-19 progression to a heavier severity level and the risk of hospitalization (75% of the general population). There were no cases of COVID-19 progression to a heavier severity level in the study drug group. By the 6th day, in the nirmatrelvir + ritonavir group, the proportion of the patients who had achieved a complete recovery was twice more and amounted to 35.61% (p=0.0001), and the proportion of the patients with a negative RNA analysis to SARS-CoV-2 was 20% higher than in the comparison group, and amounted to 82.58% (p=0.0001). The fixed nirmatrelvir + ritonavir combination therapy has a favorable safety profile comparable to the standard therapy. The identified adverse reactions were transient in nature and did not require discontinuation of therapy or changes in the treatment regimen.Conclusion. The fixed nirmatrelvir + ritonavir combination has a favorable safety profile in COVID-19 patients, comparable to the standard therapy. The data obtained demonstrate a clinical and pharmacoeconomic feasibility of including the fixed (nirmatrelvir + ritonavir) combination in the COVID-19 treatment regimen.

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Antsiferova, O. E., M. P. Teleshchenko, Yu M. Tsuverkalova, M. V. Pokrovsky, V. V. Gureev, M. A. Zatolokina y A. V. Gureeva. "CORRECTION OF MORPHOFUNCTIONAL DISORDERS IN EXPERIMENTAL PREECLAMPSY BY COMBINED USE OF TRIMETAZIDINE AND PURIFIED MICRONIZED FLAVONOID FRACTION AS WELL AS THEIR COMBINATIONS WITH METHYLAMPSY". Pharmacy & Pharmacology 8, n.º 5 (2 de marzo de 2021): 304–15. http://dx.doi.org/10.19163/2307-9266-2020-8-5-304-315.

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The aim of the experiment was to determine the effectiveness of the combined use of trimetazidine and a purified micronized flavonoid fraction, as well as their combinations with methyldopa, in comparison with monotherapy with the same drugs in the correction of morphofunctional disorders arising in the conditions of experimental preeclampsia. An integrated/multimethodology approach is the most effective way of treatment for preeclampsia. Therefore, an urgent task of modern pharmacology is to study the effectiveness of new drugs when used in combinations, as well as the drugs included in the standards for treatment.Materials and methods. The study was carried out at the Research Institute of Pharmacology of Living Systems of Belgorod State National Research University. The experiment was performed on 200 female Wistar rats, weighing 250–300 g, in which an ADMA-like model of preeclampsia had been reproduced. To assess the degree of correction of emerging morphological and functional disorders, the following parameters were involved: blood pressure, a coefficient of endothelial dysfunction, microcirculation in the placenta, proteinuria, fluid contents in the greater omentum, morphometric indicators of placental tissues and fetal height and weight parameters.Results. The combined use of trimetazidine (Preductal® MB) 6 mg/kg and a purified micronized flavonoid fraction (Detralex®) 260 mg/kg, as well as their combination with methyldopa (Dopegit®) 86 mg/kg, leads to a more pronounced decrease in the blood pressure, compared with a decrease in the coefficient of endothelial dysfunction by 2.22, 2.19 and 1.94 times, respectively, in relation to “untreated” animals. There was an increase in microcirculation indices in the placenta by 2.35, 2.21 and 2.03 times, respectively. In addition, there was an improvement in morphological parameters in the placenta and fetuses.Conclusion. The results of the study showed a greater effectiveness of the combined use of the studied drugs in experimental preeclampsia compared to their monotherapy. This indicates the prospects for the use of trimetazidine and purified micronized flavonoid fraction in the complex therapy for preeclampsia and the need for further research in this direction.

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Semerikov, V. V., N. V. Yuminova, N. O. Postanogova y L. V. Sofronova. "MUMPS: ACHIEVEMENTS, PROBLEMS AND WAYS OF SOLUTION". Pharmacy & Pharmacology 8, n.º 5 (2 de marzo de 2021): 296–303. http://dx.doi.org/10.19163/2307-9266-2020-8-5-296-303.

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The aim. The article highlights the current state of the problem of mumps in the world and the Russian Federation.Materials and methods. The materials of the study were electronic resources WHO infection control, Cohrane, Elsevier, ScienceDirect, CDC infection diseases database, PubMed, eLibrary, CyberLeninka. The research methods were the analysis and generalization of scientific literature. The assessment is presented by the immunological structure of the population in different age groups to mumps (n = 593) in the study area (2018) according to the data of the Center for Hygiene and Epidemiology in the Perm Territory.Results. The spread of mumps is found to be widespread and uneven in different regions of the world in the form of sporadic cases and large epidemic outbreaks, despite the world practice of vaccine prevention of mumps. Analysis of the immunological structure to mumps in different age groups revealed a fairly high number of seronegative individuals (the largest number was found among adults aged 20–39 years) in the study area (2018). A decrease in the tension of post-vaccination immunity is the main cause for the emergence of an outbreak among the adult population, in addition to vaccination failures among vaccinated children. The immune defenses created by the vaccine strain do not have the same intensity and duration as with natural infection, and some genotypes of “wild” variants of the mumps virus can break through the immune barrier and cause disease. Antigenic differences between vaccine and circulating strains, low inoculation dose can weaken immunity and reduce the effectiveness of mass vaccine prevention.Conclusion. Ways of solving the problem were proposed to forestall an unfavorable epidemic situation with mumps.

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Demidova, T. Yu, M. Ya Izmailova, S. E. Ushakova, K. Ya Zaslavskaya, A. A. Odegova, V. V. Popova, M. E. Nevretdinova, A. F. Verbovoy y P. A. Bely. "EVALUATION OF WEIGHT REDUCTION EFFICACY AND SAFETY OF SIBUTRAMIN-CONTAINING DRUGS IN PATIENTS WITH ALIMENTARY OBESITY". Pharmacy & Pharmacology 10, n.º 3 (25 de julio de 2022): 289–304. http://dx.doi.org/10.19163/2307-9266-2022-10-3-289-304.

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The article presents clinical study results of the efficacy and safety of combination therapy with sibutramine and metformin (fixed combination) in comparison with sibutramine therapy with microcrystalline cellulose in patients with alimentary obesity.The aim is to evaluate the efficacy and safety of using the sibutramine+metformin fixed dose combination (Reduxin® Forte) and compare it with the sibutramine + microcrystalline cellulose combination (Reduxin®) in patients with alimentary obesity in the course of the obesity therapy.Materials and methods. Male and female patients (240 people) aged 18 to 65 years inclusive with alimentary obesity, meeting the inclusion criteria and not meeting the non-inclusion criteria, were randomized into 2 groups in a 1:1 ratio. One group (n=120) received sibutramine+ metformin p. o., 1 tablet (850 mg + 10 mg) once per day, the second group (n=120) received sibutramine+ microcrystalline cellulose (MCC) p. o., 1 capsule (10 mg + 158.5 mg) once per day in the morning. On day 30 ± 1, in the absence of a 2 kg weight loss compared to the first visit, the dose was increased in accordance with the medical instruction. The therapy period was 180 days. The randomization list was generated by the factory method of random numbers. The efficacy and safety were assessed by anthropometric, clinical and laboratory parameters and the SF-36 questionnaire. The proportion of patients who achieved a decrease in body weight by more than 5% in 6 months, the magnitude and dynamics of changes in body weight and body mass index, waist and hip measurements, their ratios, changes in lipid profile, blood pressure, as well as the total number of adverse events, their frequency and nature of occurrence were analyzed.Results. The both drugs have demonstrated efficacy in all parameters of the obesity therapy. At the same time, in a comparative analysis, a statistically significant advantage of therapy with sibutramine + metformin was demonstrated in relation to the proportion of patients who had achieved more than 5% weight loss (body weight dynamics). Significant benefits were shown in terms of the magnitude of the change in body mass index (BMI); there was a statistically significant increase in the proportion of the patients who had switched from one category of BMI to another. By the end of the study, the vast majority of patients had no longer met the criteria for the diagnosis of “Obesity”. There was also a statistically significant benefit of sibutramine + metformin in terms of lowering triglycerides and low-density lipoprotein levels. The analysis of the safety parameters of sibutramine + metformin confirms a high safety profile of the drug, a comparative statistical analysis of adverse events in terms of their presence, severity, causal relationship with therapy and outcome have not revealed intergroup differences. Adverse events were transient and did not require discontinuation of therapy.Conclusion. The results of the study showed that therapy with Reduxin® and Reduxin® Forte provides a pronounced decrease in body weight. However, the use of a fixed combination has a more effective positive effect on the lipid profile and patients’ quality of life, which, combined with a high safety profile, proves the possibility and expediency of using Reduxin® Forte for the treatment of obesity and restoring metabolic health, even in patients without additional carbohydrate metabolism disorders.

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Litvinov, R. A., A. V. Gontareva, L. E. Usmiyanova y D. R. Klimenko. "INFLUENCE OF CERTAIN D-METALS ON FORMATION OF ADVANCED GLYCATION END PRODUCTS, AGGREGATION AND AMYLOID TRANSFORMATION OF ALBUMIN IN GLYCATION REACTION". Pharmacy & Pharmacology 9, n.º 4 (8 de septiembre de 2021): 306–17. http://dx.doi.org/10.19163/2307-9266-2021-9-4-306-317.

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The aim of the research is to investigate the influence of the factor of the glycation behavior of bovine serum albumin (BSA) by glucose, and the factor of d-metal cations (nickel (II), cobalt (II), iron (II), iron (III), copper (II) or zinc (II)) presence, on the process of aggregation and the amyloid transformation of BSA and, therefore, to establish the effect of these cations on the rate of the formation of advanced glycation end products (AGEs), and the intensity of fluorescence of the amino acids tyrosine and tryptophan.Materials and methods. Reagents in the glycation are: glucose (at the final concentration of 0.36 M), BSA (at the final concentration of 1 mg/ml), deionized water, one of the d-metal cations, i. e. nickel (II), cobalt (II), iron (II), iron (III), copper (II) or zinc (II) (in the form of chloride, sulfate or nitrate salts, at the final concentration of 40 μM). The conditions for the glycation reaction are the incubation for 24 hours at the temperature of 60°C. The influence of two factors (the factor of the glycation reaction and the factor of a d-metal ion presence in the reaction medium) on the concentration of glycation end products (AGEs) formed during the glycation reaction, on the fluorescence intensity of the amino acids tryptophan and tyrosine, on the aggregation of BSA, and on the ability of BSA to the amyloid transformation under the described conditions, have been studied.Results. It was found out that the studied factors have a statistically significant effect on the considered parameters. The highest activity was found for the copper ion (II), which intensifies the formation of the AGEs in the samples where glycation occurs, reduces the fluorescence intensity of the amino acids’ tryptophan and tyrosine (independently and increasing the effect against the background of glycation). Besides, it independently causes the aggregation of BSA hereby intensifying the effect against the background of glycation, it independently causes the amyloid transformation of BSA enhancing the effect against the background of glycation. The above-listed effects were the least pronounced in the reaction media with the addition of nickel (II) or cobalt (II). These cations reduce the rate of the AGEs formation, do not cause the formation of protein aggregates. In the presence of glucose, nickel (II) weakly suppresses the fluorescence intensity of tryptophan and tyrosine, and slightly enhances the amyloid transformation of BSA. Cobalt (II) slightly inhibits the amyloid transformation of BSA. In terms of the severity and nature of the effects, the iron (II), iron (III) and zinc (II) cations occupy an intermediate position between copper (II), on the one hand, and nickel (II) and cobalt (II), on the other hand, combining the influence on the AGEs formation, the intensity of fluorescence of tryptophan and tyrosine, the aggregation and amyloid transformation of BSA. In the absence of glucose, the ability of zinc (II) to induce the formation of protein aggregates turned out to be the highest, and its ability to stimulate the amyloid transformation of BSA corresponded to that of copper (II).Conclusion. The presence of d-metal cations affects the rate of the AGEs formation in the glycation reaction, affects the rate of the BSA amyloid transformation and the protein aggregates formation. Among such ions as nickel (II), cobalt (II), iron (II), iron (III), copper (II) and zinc (II), copper (II) ions turned out to be the most active in their ability to accelerate the AGEs formation, suppress the fluorescence of tryptophan and tyrosine, enhance the aggregation and amyloid transformation of BSA in the glycation reaction. The least manifestation of these properties is observed for nickel (II) and cobalt (II) ions.

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Korokin, М. В., M. V. Kubekina, A. V. Deykin, O. V. Antsiferov, V. M. Pokrovskii, L. V. Korokina, N. L. Kartashkina et al. "STUDY OF THE PHARMACOLOGICAL ACTIVITY OF NOVEL EPOR/CD131 HETERORECEPTOR AGONISTS IN MICE WITH ENDOTHELIAL-SPECIFIC EXPRESSION OF MUTANT POLG GENE". Pharmacy & Pharmacology 9, n.º 4 (8 de septiembre de 2021): 294–305. http://dx.doi.org/10.19163/2307-9266-2021-9-4-294-305.

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The aim of the research was to study antiatherosclerotic and endothelial kinds of a protective activity of peptides mimicking an erythropoietin a-helix B tertiary structure with laboratory codes EP-11-1 (UEHLERALNSS), EP-11-2. (UEQLERALNCS), EP-11-3 (UEQLERALNTS).Materials and methods. The study was conducted on 96 C57Bl/6J male double transgenic Polgmut/mut/Cdh5-CRE mice. Atherosclerosis was induced by a balloon injury accompanied by Western diet. Then, for 27 days, the drugs under study were administered once per 3 days at the dose of 20 μg/kg. On the 28th day, the animals were euthanized and the area of atherosclerotic plaques was collected for an assessment. The expression of genes associated with the processes of inflammation, apoptosis, and angiogenesis was determined in the tissues of the aorta. In addition, the endothelial protective effect of peptides in isolated segments of the thoracic aorta of wild and transgenic ransgenic Polgmut/mut mice was studied.Results. The assessment of the plaque size in the animals with the Polgmut/mut/Cdh5-CRE genotype against the background of the peptides under study did not reveal statistically significant differences in comparison to control. However, a quantitative PCR showed a statistically significant decreased expression of pro-apoptotic factors p-53 and Bax, and also increase the expression of anti-apoptotic factor Bcl-2 against the background of the peptides EP-11-1 and EP-11-2 administration. The administration of EP-11-1 and the original peptide pHBSP resulted in a statistically significant decrease in the Bax/Bcl-2 ratio. Compounds EP-11-1, EP-11-2, and EP-11-3 were more effective than the original peptide pHBSP, in reducing the increased expression of genes for inflammatory markers iNos, intercellular adhesion molecules Icam-1, Vcam-1 and E-selectin. The use of EP-11-1 led to a more efficient, in comparison with pHBSP, restoration of endothelial-dependent vasodilation of the aortic segments in mice with endothelial-specific overexpression of the mutant Polg gene.Conclusion. The study carried out on a murine model of the endothelial-specific expression of mutant gamma polymerase has shown that derivatives of the pHBSP peptide with laboratory codes EP-11-1, EP-11-2, EP-11-3, obtained by BLAST-searching for groups of pHBSP related peptides, have atheroprotective and endothelial protective kinds of a protective activity, which is more pronounced in comparison with the original peptide pHBSP.

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Hladkykh, F. V. "CHARACTERISTIC OF MECHANISMS OF ANTIULCEROGENIC ACTION OF AGENTS OF VANILLOID RECEPTORS (TRPV1) ON THE MODEL OF GASTROPATHY INDUCED BY ACETYLSALICYLIC ACID". Pharmacy & Pharmacology 5, n.º 3 (1 de enero de 2017): 283–301. http://dx.doi.org/10.19163/2307-9266-2017-5-3-283-301.

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Kovalskaya, G. N. y E. N. Mikhalevich. "EXTEMPORANEOUS MANUFACTURING OF INTRAVENOUS ADMIXTURES IN HOSPITAL PHARMACIES OF RUSSIAN FEDERATION". Pharmacy & Pharmacology 5, n.º 4 (1 de enero de 2017): 306–17. http://dx.doi.org/10.19163/2307-9266-2017-5-4-306-317.

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Kompantsev, D. V., V. M. Kishchenko, D. V. Veselova y K. N. Koryanova. "TO THE JUBILEE OF PROFESSOR STEPANOVA ELEONORA FEDOROVNA". Pharmacy & Pharmacology 6, n.º 3 (16 de julio de 2018): 309–14. http://dx.doi.org/10.19163/2307-9266-2018-6-3-309-314.

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The article is devoted to the anniversary of Professor Eleonora Fedorovna Stepanova – a bright representative of the Russian intelligentsia: a talented lecturer, an inventor, an author of numerous books, an internationally recognized scholar!

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Nemyatykh, O. D., I. I. Terninko, A. S. Sabitov, A. I. Lyashko y Z. B. Sakipova. "EVALUATION OF PLANT-BASED UV FILTERS POTENTIAL IN MODERN CONCEPT VIEW OF SKIN PHOTOPROTECTION". Pharmacy & Pharmacology 10, n.º 4 (29 de octubre de 2022): 308–19. http://dx.doi.org/10.19163/2307-9266-2022-10-4-308-319.

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A therapeutic plants potential is based on the pharmacological effects due to their phytochemical profile. Today, scientific interest in botanicals is increasing as a result of recent research that looks at the prospect of using these raw materials for the cosmetic industry as a means to protect the skin from the harmful effects of UV rays.The aim of the study was to evaluate a potential of plant-based UV-filters in modern concept view of skin photoprotection.Materials and methods. A systematic literature search was carried out using the electronic information arrays PubMed, Scopus, Google Scholar, eLibrary. The search depth was 10 years (the period from 2010 to 2021). The search was carried out by the following keywords: antioxidants, cosmetics, photoprotection, chemical composition, pharmacological action.Results. In the paper, modern principles of skin photoprotection based on the use of chemical or physical UV-filters are considered and scientifically substantiated A trend for the use of plant-based materials and their components in the formulation of photoprotectors was notified. That is associated with a wide activity spectrum, the absence of a xenobiotic effect, and a high bioavailability of organic plant compounds.Conclusion. The data analysis from scientific publications demonstrated a potential photoprotective activity of plant-based biologically active substances due to antioxidant, anti-inflammatory and anti-radical effects. The results of the study are a theoretical basis for a further comprehensive experimental study of plant objects in order to obtain a pool of evidence in the field of photoprotection in in vivo experiments.

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Al-Humairi, A. H., D. L. Speransky, V. V. Novochadov, S. V. Poroisky, N. V. Cherdyntseva y V. V. Udut. "Antitumor activity of three new azoloazine derivatives in orthotopic transplantation model of human breast cancer cells into mice". Pharmacy & Pharmacology 11, n.º 4 (9 de enero de 2024): 291–300. http://dx.doi.org/10.19163/2307-9266-2023-11-4-291-300.

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Breast cancer (BC) is one of the most common types of malignant tumors, which makes scientific research in this area extremely relevant. The difficulties of breast cancer chemotherapy stimulate the search for new drugs to treat this nosology. Derivatives of imidazotriazine and imidazotetrazine, which are analogues of the antitumor drug temozolamide, can be ones of the promising drugs in this regard.The aim of the work was to evaluate the antitumor activity of three new azoloazine derivatives in a xenogeneic breast cancer model in mice in vivo.Materials and methods. A study was conducted on a xenogeneic model of BC. After the immunosuppression with azathioprine, 48 white BALB/c mice were injected with MCF-7 cells, test derivatives, and the reference drug epirubicin at doses of 1/2 IC50 and 1/10 IC50, into the base of the mammary gland once. The body weight of the mice was monitored; on the 15th day, at the end of the experiment, the relative volume was assessed.Results and discussion. Among the three compounds studied, imidazotetrazine 1 showed the most encouraging results: stopping the loss of body weight in the mice caused by the administration of tumor cells, and reducing the tumor volume on the 15th day of the experiment to 50.6% of that in the control when using a dose of 1/10 IC50, up to 39.2% – when using a dose of 1/2 IC50, which significantly exceeded the values of the reference drug epirubicin and the values in the control group. In the histological examination, the signs of spread and preservation of tumor cells viability of the MCF-7 line after its administration were minimal, the value of the histological malignancy index decreased by 9.3% of the control value.Conclusion. Among the tested azoloazine derivatives, 3-cyclohexyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-N-piperidinylcarboxamide is the undisputed leader, causing inhibition of the tumor growth in a xenogeneic model in vivo.

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O’Leary, Jared M., Tufik R. Assad, Meng Xu, Kelly A. Birdwell, Eric Farber-Eger, Quinn S. Wells, Anna R. Hemnes y Evan L. Brittain. "Pulmonary hypertension in patients with chronic kidney disease: invasive hemodynamic etiology and outcomes". Pulmonary Circulation 7, n.º 3 (29 de junio de 2017): 674–83. http://dx.doi.org/10.1177/2045893217716108.

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Pulmonary hypertension (PH) is common in patients with chronic kidney disease (CKD) and associated with increased mortality but the hemodynamic profiles, clinical risk factors, and outcomes have not been well characterized. Our objective was to define the hemodynamic profile and related risk factors for PH in CKD patients. We extracted clinical and hemodynamic data from Vanderbilt’s de-identified electronic medical record on all patients undergoing right heart catheterization during 1998–2014. CKD (stages III–V) was defined by estimated glomerular filtration rate thresholds. PH was defined as mean pulmonary pressure ≥ 25 mmHg and categorized into pre-capillary and post-capillary according to consensus recommendations. In total, 4635 patients underwent catheterization: 1873 (40%) had CKD; 1518 (33%) stage 3, 230 (5%) stage 4, and 125 (3%) stage 5. PH was present in 1267 (68%) of these patients. Post-capillary (n = 965, 76%) was the predominant PH phenotype among CKD patients versus 302 (24%) for pre-capillary ( P < 0.001). CKD was independently associated with pulmonary hypertension (odds ratio = 1.4, 95% confidence interval = 1.18–1.65). Mortality among CKD patients rose with worsening stage and was significantly increased by PH status. PH is common and independently associated with mortality among CKD patients referred for right heart catheterization. Post-capillary was the most common etiology of PH. These data suggest that PH is an important prognostic co-morbidity among CKD patients and that CKD itself may have a role in the development of pulmonary vascular disease in some patients.

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Brown, Justin C., Michael H. Rosenthal, Chao Ma, Sui Zhang, Halla S. Nimeiri, Nadine J. McCleary, Thomas A. Abrams et al. "Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial". Cancers 12, n.º 11 (20 de noviembre de 2020): 3451. http://dx.doi.org/10.3390/cancers12113451.

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Skeletal muscle and adipose tissue express the vitamin D receptor and may be a mechanism through which vitamin D supplementation slows cancer progression and reduces cancer death. In this exploratory analysis of a double-blind, multicenter, randomized phase II clinical trial, 105 patients with advanced or metastatic colorectal cancer who were receiving chemotherapy were randomized to either high-dose vitamin D3 (4000 IU) or standard-dose (400 IU) vitamin D3. Body composition was measured with abdominal computed tomography at enrollment (baseline) and after cycle 8 of chemotherapy (16 weeks). As compared with standard-dose vitamin D3, high-dose vitamin D3 did not significantly change body weight [−0.7 kg; (95% CI: −3.5, 2.0)], body mass index [−0.2 kg/m2; (95% CI: −1.2, 0.7)], muscle area [−1.7 cm2; (95% CI: −9.6, 6.3)], muscle attenuation [−0.4 HU; (95% CI: −4.2, 3.2)], visceral adipose tissue area [−7.5 cm2; (95% CI: −24.5, 9.6)], or subcutaneous adipose tissue area [−8.3 cm2; (95% CI: −35.5, 18.9)] over the first 8 cycles of chemotherapy. Among patients with advanced or metastatic colorectal cancer, the addition of high-dose vitamin D3, vs standard-dose vitamin D3, to standard chemotherapy did not result in any changes in body composition.

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ZEINODDINI, VAHID y BENJAMIN W. SCHAFER. "GLOBAL IMPERFECTIONS AND DIMENSIONAL VARIATIONS IN COLD-FORMED STEEL MEMBERS". International Journal of Structural Stability and Dynamics 11, n.º 05 (octubre de 2011): 829–54. http://dx.doi.org/10.1142/s0219455411004361.

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The objective of this paper is to provide the results from an experimental program to measure global imperfections and dimensional variations in cold-formed steel-lipped channel members. Measurements were conducted at seven different manufacturing plants in the United States. A total of 210 cross sections were measured for global imperfections. Each cross section was measured at three locations, and every 305 mm (12 in.) along the length. The data is used to characterize global bow, camber, and twist. The majority of the data exhibits global imperfections well approximated by a half sine-wave. Further, global bow imperfections are shown to have a systematic bias in the direction of bow. The measured data is compared with manufacturing tolerances (e.g., L/384) and assumed imperfection sizes from column curves (e.g., L/960) as utilized in design practice in the United States. The measured imperfections served as justification for tightening manufacturing tolerances in the United States (e.g., to L/960). Dimensional variation of typical cold-formed steel members is also measured and compared with tolerances. The measured data provides much needed input for nonlinear analysis of cold-formed steel structures.

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Millard-Stafford, Melinda L., Mary Beth Brown y Teresa K. Snow. "Acute Carbohydrate Ingestion Affects Lactate Response in Highly Trained Swimmers". International Journal of Sports Physiology and Performance 5, n.º 1 (marzo de 2010): 42–54. http://dx.doi.org/10.1123/ijspp.5.1.42.

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Purpose:Effects of acute carbohydrate ingestion on blood lactate (BLa) response to graded exercise was examined in highly trained male and female swimmers.Methods:Twenty-three swimmers performed the United States Swimming Lactate Protocol, a graded interval test (5 × 200 on 5 min), following ingestion of carbohydrate sports drink (CHO) and placebo (PLA).Results:There was no difference in heart rate (P = .55), swim velocity (P = .95), or ratings of perceived exertion (P = .58) between beverages. There was a signifcant main effect for gender (P = .002) on BLa during all swim stages and recovery. In females, BLa was 27% to 50% higher for CHO during the first (P = .009) and second (P = .04) swim stages. Predicted BLa at selected swim velocity was higher (P = .048) for CHO versus PLA in females at 1.27 m·s−1 and higher (P < .02) for men at 1.4 m·s−1. Mean (±SD) BLa was significantly (P = .004) greater for CHO (2.7 ± 1.2) compared with PLA (2.0 ± 1.1 mmol·L−1) during the second test stage and when normalized relative to velocity (P = .004). Peak BLa after the final swim (9.6 ± 3.1 vs. 9.0 ± 3.2 mmol·L−1, P = .36) was not different between CHO and PLA.Conclusions:Acute CHO ingestion alters the BLa: swim velocity relationship during moderate intensity swims of an incremental swim test, particularly for females. Therefore, pretest beverage ingestion should be standardized during the administration of BLa testing to prevent potential erroneous interpretations regarding athlete’s training status.

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Koshelev, V. N. y N. V. Kolpakov. "Species composition and distribution of fishes and prawns in the Amur River channel". Izvestiya TINRO 200, n.º 2 (5 de julio de 2020): 292–307. http://dx.doi.org/10.26428/1606-9919-2020-200-292-307.

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istribution of fishes and prawns in the Amur River (40–960 km from the mouth) is described on results of the beam-trawl survey conducted in September-October, 2003 (57 trawl stations at the depth of 1.5–23.0 m). In total, 2584 ind. of 22 fish species and 1077 ind. of 1 invertebrate species (prawn Palaemon modestus) were caught. The highest species richness was registered for orders Cypriniformes (13 species) and Siluriformes (4 species). The fish and prawn stocks were evaluated as 32.161 . 106 ind. (583.8 t) for bottom and near-bottom fish and 4.887 . 106 ind. (8.8 t) for prawns. Two commercial fish species were the most abundant: catfishes Tachysurus brashnikowi (16.26 . 106 ind. or 32.9 % of total biomass) and T. sinensis (4.32 . 106 ind. or 24.0 % of total biomass); other 6 fish species with considerable biomass were lizard gudgeon Saurogobio dabryi (12.6 %), ussuri catfish T. ussuriensis (9.7 %), amur white-pinned gudgeon Romanogobio tenuicorpus (7.8 %), amur sturgeon Acipenser schrenckii (5.6 %), amur gudgeon Gobio cynocephalus (2.4 %), and kaluga Huso dauricus (0.6 %). Distribution density varied in the range of 0.01–2.57 g/m2 (on average 0.45 ± 0.27 g/m2) for fish and 0.005–0.044 g/m2 (0.021 ± 0.012 g/m2) for prawns. Abundance of both fish and prawns increased multifold towards the Amur mouth that correlated with increasing of forage benthos biomass in the same direction. So, the main portion of fish biomass (82.4 %) was distributed in the Amur River downstream (40–400 km from the mouth) and the prawn stock was concentrated completely in its lowermost part (50–150 km from the mouth).

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Ruttanapun, Chesta, Phumin Jindajitawat, Warawoot Thowladda, Worakarn Neeyakorn, Chanchana Thanachayanont y Anek Charoenphakdee. "Thermoelectric Properties of Sn²⁺-Substituted CuFeO₂ Delafossite-Oxide". Advanced Materials Research 802 (septiembre de 2013): 17–21. http://dx.doi.org/10.4028/www.scientific.net/amr.802.17.

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This study aims to investigate the effect of the Sn2+-substituted into the CuFeO2delafossite on thermoelectric properties in the Sn content of x = 0.03, 0.05. The CuFe1−xSnxO2samples were synthesized by solid state reaction. The crystal structure was characterized by XRD, TGA, XPS and the thermoelectric properties were measured in the range of 300 to 960 K. The Seebeck coefficient display positive sign in all temperature range and the XPS show the stable Sn+2state as confirming the Sn-doped CuFeO2playing p-type conductor. The Sn2+-substituted supports the mixed valency Fe3+/Fe4+state in transition octahedral oxide of FeO6layer enhancing Seebeck coefficient. The high Seebeck are appeared in content of x=0.03 which are 280 to 340 µV/K in the range of 300 to 800 K. The experimental Seebeck corresponds to the prediction formula at high temperature. Totally, the maximum Power Factor is 2.30×10−4W/mK2occurring in the CuFe0.95Sn0.05O2at 860 K which is higher than that value of the undoped-CuFeO2in 4 times. These support that the Sn-substituted CuFeO2delafossite enhancing thermoelectric properties.

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B. M., Rupakala y Akshata S. Hiremath. "Comparative study of 24-hour urinary protein and spot urine protein creatinine ratio in pre-eclamptic women". International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, n.º 7 (28 de junio de 2021): 2734. http://dx.doi.org/10.18203/2320-1770.ijrcog20212659.

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Background: The aim of the study was to evaluate the ability of the random urine P/C ratio to predict significant proteinuria, as well as to introduce a diagnostic test for pre-eclampsia which will avoid the inconvenience and time consumption of 24-hour urine protein collection. The objective of this study was to compare spot urine protein- creatinine ratio with 24-hour urine protein for estimation of proteinuria in pre-eclampsia.Methods: A total of 50 pregnant women with pre-eclampsia were prospectively studied for proteinuria in Rajarajeswari medical college and Hospital Bangalore for a period of 9 months from September 2018 to May 2019. Spot urine specimens for measuring P/C ratio were obtained immediately before 24-hour urine collection. The correlation between the spot urine P/C ratio and urinary protein excretion in the 24-hour collections was examined using the Spearman correlation test.Results: PCR at a cut off value 0.15 g/mmol had sensitivity and specificity of 96.6% and 55% respectively. In prediction of proteinuria of 300 mg/24 hr positive predictive value and negative predictive value 76.3% and 91.6% respectively.Conclusions: We found that there was a strong correlation between 24-hour urine protein excretion and spot urine protein creatinine ratio in pre-eclamptic women. Spot PCR can be used as a reasonable alternative to 24-hour urine protein test which is a cumbersome.

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Dahl, Ola E., Andreas A. Kurth, Nadia Rosencher, Janet Schnee, Andreas Clemens, Herbert Noack y Bengt I. Eriksson. "Efficacy and Safety Profile of Dabigatran Etexilate Compared with Enoxaparin in Primary Venous Thromboembolism Prevention after Total Knee or Hip Replacement Surgery in Patients Over 75 Years". Blood 112, n.º 11 (16 de noviembre de 2008): 437. http://dx.doi.org/10.1182/blood.v112.11.437.437.

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Abstract The oral direct thrombin inhibitor, Dabigatran etexilate (Pradaxa®), was recently approved in Europe for the prevention of venous thromboembolism (VTE) in patients undergoing elective total knee replacement or total hip replacement surgery. Two pivotal clinical trials studied doses of 220 mg once daily and 150 mg once daily compared with 40 mg enoxaparin. A post hoc pooled analysis was performed in elderly patients (>75 years) since the elderly, naturally lose renal function with aging. The efficacy and safety of once daily 220 mg and 150 mg dabigatran etexilate were compared with 40 mg subcutaneous enoxaparin using pooled data from the RE-MODEL (Eriksson BI et al. J Thromb Haemost2007; 5: 2178–2185) and RE-NOVATE (Eriksson BI et al. Lancet2007; 370: 949–956) pivotal trials. The primary efficacy endpoint was total VTE and all cause mortality and the primary secondary efficacy endpoint was major VTE and VTE related mortality. The primary safety endpoint was bleeding events, which were blindly adjudicated and categorized as major bleeding events (MBE), including surgical site bleeds. Of the patients treated with 220 mg dabigatran etexilate (1825), 150 mg dabigatran etexilate (1866) and enoxaparin (1848), 883 patients (16%) were above the age of 75, 73% of the elderly were evaluable for the primary efficacy endpoint, 75% were evaluable for the secondary efficacy endpoint, and all elderly patients were evaluable for safety including bleeding. The incidence of total VTE and all cause mortality was 20.8%, 22.6%, and 27.2% respectively in the three groups. A similar trend was observed for the secondary endpoint major VTE and VTE related mortality, with a descriptive statistical significant lower event rate in the 220 mg group (see table). MBEs occurred in 11 of the 295 elderly receiving 220 mg dabigatran etexilate (3.7%), 4 of the 282 elderly receiving 150 mg dabigatran etexilate (1.4%) and in 9 of the 306 elderly taking enoxaparin (2.9%). Notably, 6 of the 11 MBE in the dabigatran 220 mg group and 2 of the 4 MBE in the 150 mg group started before first oral treatment. In conclusion, in elderly patients (>75 years) undergoing hip or knee replacement surgery, oral 150 mg dabigatran etexilate exhibited favourable bleeding profile with no difference in efficacy compared to 40 mg enoxaparin. Because safety is of paramount importance in the elderly who are at risk of any complications, the 150 mg once daily of dabigatran etexilate dose is currently recommended for this group. Table 1: Efficacy and bleeding endpoints in patients older than 75 years (p-value from Fisher’s exact test compared to Enoxaparin) Event Dabigatran etexilate 220 mg qd Dabigatran etexilate 150 mg qd Enoxaparin 40 mg qd Total VTE and all cause mortality 20.8% (44/212) (CI 15.5%–26.8%) p=0.14 22.6% (49/217) (CI 17.2%–28.7%) p=0.32 27.2% (58/213) (CI 21.4%–33.7%) Major VTE and VTE related mortality 1.9% (4/216) (CI 0.5%–4.7%) p=0.045 4.5% (10/221) (CI 2.2%–8.2%) p=0.53 6.0% (13/218) (CI 3.2%–10.0%) MBE 3.7% (11/295) (CI 1.9%–6.6%) p=0.65 1.4% (4/282) (CI 0.4%–3.6%) p=0.27 2.9%% (9/306) (CI 1.4%–5.5%)

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Lestari, Nyoto, Helmy Purwanto y Muhammad Dzulfikar. "Analisis Sifat Mekanis Baja Karbon Menengah Akibat Proses Austenisasi Tempering". Jurnal Ilmiah MOMENTUM 17, n.º 2 (30 de octubre de 2021): 127. http://dx.doi.org/10.36499/jim.v17i2.5613.

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Perlakuan panas (heat treatment) didefinisikan sebagai kombinasi proses pemanasan dan pendinginan untuk mendapatkan sifat-sifat tertentu pada baja atau paduan lainnya. Salah satu proses perlakuan panas tersebut dengan proses quenching dan tempering. Proses ini dilakukan pada temperatur austenite 700 oC, 800 oC, 900 oC dengan media pendingin celup oli, kemudian di lanjutkan proses tempering pada temperatur 100 oC, 200 oC, 300 oC, dan 400 oC dengan waktu penahanan 15 menit. Hasil pengujian pada uji struktur mikro memperlihatkan bahwa fasa yang banyak terlihat adalah fasa perlit, sedangkan fasa martensit jarang ditemukan. Hasil pengujian kekerasan memperlihatkan bahwa nilai tertinggi adalah 591 HVN terdapat pada temperatur austenite 900 oC dan di tempering pada temperatur 200 oC. Hasil pengujian tarik mendapatkan Maksimal Stress tertinggi pada temperatur austenite 900 oC dan temperatur tempering 100 oC dengan nilai 961 MPa. Pengujian impak mendapat nilai 0,40J/mm2 yang terdapat pada temperatur austenite 900 oC dan temperatur tempering 400 oC. Proses tempering dapat menurunkan nilai kekerasan dan kekuatan tarik dan pada uji impak nilai kekerasan meningkat. Sementara hasil mikro struktur memperlihatkan bahwa jumlah fasa-fasenya hampir sama dengan raw material.

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42

Shatokhin, S. S., V. A. Tuskaev, S. Ch Gagieva, D. I. Pozdnyakov y E. T. Oganesyan. "SYNTHESIS AND ANTIOXIDANT ACTIVITY OF (E)-3-(3-(4-OXO-4H-CHROMEN-3-YL)ACRYLOYL) 2H-CHROMEN-2-ONE DERIVATIVES". Pharmacy & Pharmacology 9, n.º 5 (25 de octubre de 2021): 367–76. http://dx.doi.org/10.19163/2307-9266-2021-9-5-367-376.

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The aim is based on the results of the in silico prediction, to obtain and characterize a number of (E)-3-(3-(4-oxo-4H-chromen-3-yl)acryloyl)-2H-chromen-2-one derivatives, and also to study their antioxidant activity.Materials and methods. The synthesis of the target compounds was carried out by condensation of substituted 3-formylchromones and 3-acetylcoumarins under the acid catalysis conditions. 1H NMR spectra were recorded on the instruments of Bruker Avance-400 (400 MHz) and Bruker Avance-300 (300 MHz) in the solutions of CDCl3 or DMSO-d6. Mass spectra (ESI) were obtained on a Finnigan LCQ Advantage mass spectrometer (USA). The melting points of the compounds were determined on a PTP (M) instrument. Quantum-chemical calculations were carried out on the basis of a density functional theory using the Gaussian 09 program using the B3LYP/6-311G (d, p) method, as well as using the Way2Drug (PASS Online) online service. The antiradical activity of the compounds was studied by the DPPH test, and the chelating properties were assessed by the o-phenanthroline method.Results. 15 derivatives of (E)-3-(3-(4-oxo-4H-chromen-3-yl)acryloyl)-2H-chromen-2-one have been obtained and characterized. The calculations based on the density functional theory showed that the highest occupied molecular orbital exhibiting electron-donating properties is localized on the propenone fragment, which confirms the likelihood of the manifestation of antiradical properties. According to the prediction of the probable spectrum of the biological activity, the obtained compounds are more likely to exhibit their direct antioxidant activity. According to the results of the in vitro study of the antioxidant activity, it was found out that compounds 1-15 are the most active in relation to the DPPH radical, which confirms the obtained prognostic data.Conclusion. Thus, based on the in silico prediction data, 15 derivatives of (E)-3-(3-(4-oxo-4H-chromen-3-yl)acryloyl)-2H-chromen-2-one have been obtained and characterized, for which the method antioxidant activity has been studied in vitro. It was found out that compounds 1-15 exhibit the antiradical activity to a large extent.

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Oseshnyuk, R. A., A. G. Nikiforova, A. Yu Boroduleva, P. D. Sobolev, S. A. Lesnichuk, B. B. Garyaev, A. A. Abramova et al. "Bioequivalence study of generic nirmatrelvir in healthy volunteers". Pharmacy & Pharmacology 11, n.º 1 (28 de abril de 2023): 62–71. http://dx.doi.org/10.19163/2307-9266-2023-11-1-62-71.

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Nirmatrelvir is an antiviral drug that, in combination with ritonavir, is an effective agent for the etiotropic therapy of patients with mild to moderate COVID-19.The aim of the study was to evaluate bioequivalence of the generic drug nirmatrelvir Аrpaxel in combination with ritonavir and the original drug Paxlovid, which is a combination of nirmatrelvir/ritonavir, in a single dose administration to healthy volunteers.Materials and methods. This research was an open-label, randomized, two-period crossover bioequivalence study. It included 2 periods, in each of which the volunteers received either a test drug (nirmatrelvir at the dose of 300 mg) in combination with ritonavir (100 mg), or a reference drug (a combination of nirmatrelvir 300 mg and ritonavir 100 mg), given as a single dose. A wash-out period between each of the administrations was 7 days. The blood sampling to determine the concentration of nirmatrelvir was carried out in the range from 0 to 36 h in each of the study periods. A nirmatrelvir concentration was determined by a validated HPLC-MS/MS method with a lower quantitation limit of 10 ng/mL. Bioequivalence was assessed by comparing 90% confidence intervals (CIs) for the ratio of geometric means of AUC(0–16) and Cmax of the test drug and reference drugs with the established equivalence limits of 80.00–125.00%.Results. In the study were included 68 healthy volunteers, 67 participants of which were included in the bioequivalence population. The pharmacokinetic parameters of the drugs were comparable to each other. The 90% confidence interval for the ratio of the geometric mean of the maximum drug concentration in the blood plasma and the area under the pharmacokinetic curve «concentration-time» from zero to the last blood draw within 36 hours of nirmatrelvir was 87.26–100.83 and 93.27–103.74%, which meets the criteria for assessing bioequivalence. The test drugs were well tolerated by the volunteers. The incidence of adverse events was similar for the test and reference drugs. No serious adverse events were recorded during the entire study.Conclusion. As a result of this study, bioequivalence of the test and reference drugs has been established.

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Husin, M., L. S. Marhaeni y C. Tresniawati. "Effect of Rootone-F concentration on the cutting-growth of three species of coffee (Coffea sp.)". IOP Conference Series: Earth and Environmental Science 974, n.º 1 (1 de enero de 2022): 012065. http://dx.doi.org/10.1088/1755-1315/974/1/012065.

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Abstract Liberica, Robusta and Excelsa coffee are cross-pollinated so that their vegetative propagation uses cuttings. Plant growth regulators (PGR) such as Rootone-F could accelerate root growth on cuttings. The study aimed to determine the effect of Rootone-F concentration on the growth of one segment cuttings. The study was conducted at the Indonesian Industrial and Beverage Crops Research Institute (IIBCRI) from January to March 2020. The research design was a factorial, Completely Randomized Design, with three replications. The first factor was coffee species, i.e., Robusta (BP 936), Liberica (LIM 1 and LIM 2), and Excelsa, and the second factor was Rootone-F concentrations were 0, 100, 200, 300, 400, and 500 ppm. The characters observed were callus diameter, leaves number, shoots number, and leaf length. The results showed there was an interaction between coffee species and Rootone-F concentration on shoots number and leaf length. Every factor affected callus diameter and leaves number, respectively. Application without Rootone-F (0 ppm) gave a higher value of callus diameter and leaves number of LIM 1. Rootone-F concentration that could increase the shoots number and leaf length was 500 ppm for Lim 1, 400 ppm for Lim 2, 0 ppm for BP 936, and 100 ppm for Excelsa.

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Naik, Muzafar, Tariq Bhat, Ummer Jalalie, Arif Bhat, Mir Waseem y Mohd Tahir Ganayie. "Efficacy and safety of high dose accelerated intravenous iron sucrose in patients of iron deficiency anemia". International Journal of Research in Medical Sciences 5, n.º 8 (26 de julio de 2017): 3359. http://dx.doi.org/10.18203/2320-6012.ijrms20173157.

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Background: Low dose (200 mg) extended Intravenous iron sucrose remains the most common treatment option in patients who are intolerant to oral iron therapy in patients with Iron deficiency anemia (IDA). The objective of this study was to evaluate the efficacy and safety of high dose accelerated intravenous iron sucrose (IS) in the treatment of adults with iron deficiency anemiaMethods: One hundred adult patients with iron deficiency anemia, who had intolerance or showed no effect with oral iron therapy, received daily doses of 500 mg of intravenous iron sucrose until the hemoglobin level was corrected or until receiving the total dose of intravenous iron calculated for each patient.Results: The mean and median Hb (g/dL) 6.47±1.656 and 6.6 (2) at baseline, 9.61±1.629 and 9.6 (2) at 2 weeks of treatment, 11.85±1.277 and 12 (1) at 4 weeks of treatment respectively. The mean rise of Hb was 3.13±1.41 and 5.37±1.50 after 2 and 4 weeks of treatment respectively (p<0.000). A total of 303 intravenous infusions of iron sucrose were administered and iron sucrose was generally well tolerated with twenty-six patients developing mild and one patient developing moderate adverse drug reactions. There was no serious adverse event recorded.Conclusions: Accelerated high dose intravenous iron sucrose is a safe and cost effective option minimizing frequent hospital visits in the treatment of adults with iron deficiency anemia who are intolerant or lack satisfactory response to oral iron therapy.

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Janakiraman, Nalini, UshaSree Chamarthy, Radhika Acharya, Vijaya Donthireddy, Ginny Kamboj, Nancy Oja-Tebbe y George Divine. "Mel-140 and TBI vs Mel-200 Prior to Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma - a Single Institution Experience." Blood 104, n.º 11 (16 de noviembre de 2004): 5209. http://dx.doi.org/10.1182/blood.v104.11.5209.5209.

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Abstract Between 1991–98, twenty-nine patients with myeloma received Mel-140 and TBI (960 cGy) followed by Cytoxan mobilized autologous PBSCT. Between 1998 and April, 2004, 41 patients received Mel-200 alone followed by autologous PBSCT. The two groups were comparable regarding age, gender, stage, number of prior regimens and ß2 microglobulin at diagnosis. However, the Mel-200 group had greater proportion of patients with IgG myeloma (78% vs 38%) and shorter time from diagnosis to transplant (301 days vs 581 days). Results: Neutrophil engraftment was similar in the two groups. However, platelet engraftment, transfusion requirements, length of stay and number of days on antibiotics were worse in the Mel-TBI group. The complete and very good partial responses were high in both groups Mel TBI 58.6% vs Mel-200 56% (p=0.81). Median overall survival (OS) was 3.5 years and 3.8 years for Mel TBI and Mel-200 groups, respectively (p=0.75). Event-free survival (EFS) was 1.9 years and 2.3 years, respectively (p=0.88). Survival after relapse post-PBSCT was short, median 1.1 and 1.8 years, respectively. We present here the results of two groups of myeloma patients treated consecutively in a single institution. The Mel-200 patients had a higher proportion of IgG myeloma and were transplanted earlier in the phase of their disease. As expected, regimen-related toxicities were higher in the Mel-TBI group. The response rates, OS, and EFS were similar. These results are in keeping with published reports of prospective randomized studies. Mel-200 is now the standard conditioning regimen for autologous transplant for myeloma.

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Rocheleau, Tristan, Steen Rasmussen, Peter E. Nielsen, Martin N. Jacobi y Hans Ziock. "Emergence of protocellular growth laws". Philosophical Transactions of the Royal Society B: Biological Sciences 362, n.º 1486 (mayo de 2007): 1841–45. http://dx.doi.org/10.1098/rstb.2007.2076.

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Template-directed replication is known to obey a parabolic growth law due to product inhibition (Sievers & Von Kiedrowski 1994 Nature 369 , 221; Lee et al . 1996 Nature 382 , 525; Varga & Szathmáry 1997 Bull. Math. Biol . 59 , 1145). We investigate a template-directed replication with a coupled template catalysed lipid aggregate production as a model of a minimal protocell and show analytically that the autocatalytic template–container feedback ensures balanced exponential replication kinetics; both the genes and the container grow exponentially with the same exponent. The parabolic gene replication does not limit the protocellular growth, and a detailed stoichiometric control of the individual protocell components is not necessary to ensure a balanced gene–container growth as conjectured by various authors (Gánti 2004 Chemoton theory ). Our analysis also suggests that the exponential growth of most modern biological systems emerges from the inherent spatial quality of the container replication process as we show analytically how the internal gene and metabolic kinetics determine the cell population's generation time and not the growth law (Burdett & Kirkwood 1983 J. Theor. Biol . 103 , 11–20; Novak et al . 1998 Biophys. Chem . 72 , 185–200; Tyson et al . 2003 Curr. Opin. Cell Biol . 15 , 221–231). Previous extensive replication reaction kinetic studies have mainly focused on template replication and have not included a coupling to metabolic container dynamics (Stadler et al . 2000 Bull. Math. Biol . 62 , 1061–1086; Stadler & Stadler 2003 Adv. Comp. Syst . 6 , 47). The reported results extend these investigations. Finally, the coordinated exponential gene–container growth law stemming from catalysis is an encouraging circumstance for the many experimental groups currently engaged in assembling self-replicating minimal artificial cells (Szostak 2001 et al . Nature 409 , 387–390; Pohorille & Deamer 2002 Trends Biotech . 20 123–128; Rasmussen et al . 2004 Science 303 , 963–965; Szathmáry 2005 Nature 433 , 469–470; Luisi et al . 2006 Naturwissenschaften 93 , 1–13). 1

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Thompson, Linda Butler, Karen Schimpf y Steve Baugh. "Determination of Vitamins A and E in Infant Formula and Adult/Pediatric Nutritional Formula by HPLC with UV and Fluorescence Detection: First Action 2012.09". Journal of AOAC INTERNATIONAL 96, n.º 6 (1 de noviembre de 2013): 1407–13. http://dx.doi.org/10.5740/jaoacint.13-203.

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Abstract The method presented is for quantification of α-tocopherol (vitamin E), vitamin E acetate, vitamin A acetate, and vitamin A palmitate in infant formula and adult/pediatric nutritionals. The entire lipid fraction, including vitamins A and E, is extracted from product with iso-octane after products are mixed with methanol, which precipitates proteins and disrupts micelles freeing lipids for extraction. Vitamin A palmitate, vitamin A acetate, and vitamin E acetate are separated from α-tocopherol on a 3 cm silica column with a 1% methylene chloride, 0.06% isopropanol in iso-octane mobile phase; eluted onto a 20 cm silica column; and, after a column switch, further separated on the 20 cm column before UV detection at 325 nm (vitamin A palmitate and vitamin A acetate) and 285 nm (vitamin E acetate). α-Tocopherol is further separated from other extraneous compounds on the 3 cm silica column and detected by fluorescence at excitation and emission wavelengths of 295 and 330 nm, respectively. Quantification limits in ready-to-feed products were estimated to be 80 IU/L for vitamin A palmitate, 207 International Units (IU)/L for vitamin A acetate, 2.4 mg/L for vitamin E acetate, and <0.15 mg/L for α-tocopherol. Over-spike recoveries and intermediate precision averaged 100.4 and 2.09% RSD for vitamin A palmitate, 100.4 and 1.52% RSD for vitamin E acetate, and 99.6 and 3.02% RSD for α-tocopherol. Vitamin A acetate spike recovery data averaged 96.6%, and the intermediate precision for the only product fortified with vitamin A acetate was 2.75% RSD.

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Novita, Hera Dwi y Eka Rahmawati Wahyuningsih. "Risk factors that associated with visual outcome of community based cataract surgery". International Journal of Research in Medical Sciences 8, n.º 8 (24 de julio de 2020): 2771. http://dx.doi.org/10.18203/2320-6012.ijrms20203423.

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Background: Cataract is one of the leading cause of blindness in Indonesia and worldwide. Meanwhile the ability to carry out cataract surgery was not balanced by the increasing of cataract backlog of ± 70,000 per year. In addition to increase the number of cataract operations, it is very important to maintain the quality of surgery results by auditing the result of surgery. This study aims to evaluate post-operative visual acuity in social services organized by the Cataract Blindness Prevention Section of IOA Malang Branch in 2015-2017.Methods: This study is a retrospective study based on medical record data of cataract patients underwent cataract surgery at a social service organized by the Cataract Blindness Prevention Section of IOA Malang Branch in January 2015 - December 2017 period. Data collected included demographic data, preoperative and postoperative visual acuity, type cataract surgery, and intraoperative complications.Results: Cataract surgery carried out from 2015-2017 was 1,662 surgeries with 965 male patients (58.06%). Visual acuity before surgery was 1/300 in 583 patients (35.08%). The most cataract surgery procedure performed was SICS (60.17%). Vitreous prolapse was the most common complication found. There was a significant association between age and type of cataract surgery, with postoperative vision (p <0.05, α = 5%). From the analysis, the progress of post-operative visual acuity was found in 85.93% of patients and the results were significant (p <0.05, α = 5%).Conclusions: Cataract surgery may provide significant visual improvement that elevates vision and quality of life for patients.

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Gupta, Sudeep, Senthil Rajappa, Suresh Advani, Amit Agarwal, Shyam Aggarwal, Chanchal Goswami, Satya Dattatreya Palanki, Devavrat Arya, Shekhar Patil y Rohit Kodagali. "Prevalence of BRCA1 and BRCA2 Mutations Among Patients With Ovarian, Primary Peritoneal, and Fallopian Tube Cancer in India: A Multicenter Cross-Sectional Study". JCO Global Oncology, n.º 7 (junio de 2021): 849–61. http://dx.doi.org/10.1200/go.21.00051.

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PURPOSE There are deficient data on prevalence of germline mutations in breast cancer susceptibility genes 1 and 2 ( BRCA1/ BRCA2) in Indian patients with ovarian cancer who are not selected by clinical features. METHODS This prospective, cross-sectional, noninterventional study in nine Indian centers included patients with newly diagnosed or relapsed epithelial ovarian, primary peritoneal, or fallopian tube cancer. The primary objective was to assess the prevalence of BRCA1/ BRCA2 mutations, and the secondary objective was to correlate BRCA1/ BRCA2 status with clinicopathologic characteristics. Mutation testing was performed by a standard next-generation sequencing assay. RESULTS Between March 2018 and December 2018, 239 patients with a median age of 53.0 (range, 23.0-86.0 years) years were included, of whom 203 (84.9%) had newly diagnosed disease, 36 (15.1%) had family history of ovarian or breast cancer, and 159 (66.5%) had serous subtype of epithelial ovarian cancer. Germline pathogenic or likely pathogenic mutations in BRCA1 and BRCA2 were detected in 37 (15.5%; 95% CI, 11.1 to 20.7) and 14 (5.9%; 95% CI, 3.2 to 9.6) patients, respectively, whereas variants of uncertain significance in these genes were seen in four (1.7%; 95% CI, 0.5 to 4.2) and six (2.5%; 95% CI, 0.9 to 5.4) patients, respectively. The prevalence of pathogenic or likely pathogenic BRCA mutations in patients with serous versus nonserous tumors, with versus without relevant family history, and ≤ 50 years versus > 50 years, were 40 of 159 (25.2%; 95% CI, 18.6 to 32.6) versus 11 of 80 (13.8%; 95% CI, 7.1 to 23.3; P = .0636), 20 of 36 (55.6%; 95% CI, 38.1 to 72.1) versus 41 of 203 (20.2%; 95% CI, 14.9 to 26.4; P < .0001), and 20 of 90 (22.2%; 95% CI, 14.1 to 32.2) versus 31 of 149 (20.8%; 95% CI, 14.6 to 28.2; P = .7956), respectively. CONCLUSION There is a high prevalence of pathogenic or likely pathogenic germline BRCA mutations in Indian patients with ovarian cancer.

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