Academic literature on the topic 'ΔDwax'
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Journal articles on the topic "ΔDwax"
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Baqloul, Asmae, Enno Schefuß, Martin Kölling, Lydie Dupont, Jeroen Groeneveld, Xueqin Zhao, Hanane Reddad, Lhoussaine Bouchaou, and Ilham Bouimetarhan. "Climate and land-use effects on hydrological and vegetation signals during the last three millennia: Evidence from sedimentary leaf waxes in southwestern Morocco." Holocene 31, no. 5 (January 13, 2021): 699–708. http://dx.doi.org/10.1177/0959683620988053.
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The southwest of Morocco is considered to be an area of refuge within the Mediterranean region, hosting the endemic tropical Argan tree. This region is presently subject to severe droughts, desertification and land degradation, and likely facing increased climate variability and socio-economic stress in the future. Here, we use the stable hydrogen and carbon isotope composition (δD and δ13C) of plant-waxes in a high-resolution marine sediment core (GeoB8601-3) collected off Cape Ghir in southwestern Morocco, in combination with published data on pollen and XRF element ratios from the same archive. We aim to reconstruct the hydroclimate and vegetation history during the last 3000 years. Stable carbon isotope compositions of leaf waxes (δ13Cwax) show that natural vegetation in southwestern Morocco consists of C3 plants. Minor variations in δ13Cwax were positively correlated to changes in stable hydrogen isotope compositions of leaf waxes (δDwax) before 700 CE. Changes in rainfall amounts and water use efficiency indicate a clear vegetation response to precipitation changes and thus to climate forcing. After 700 CE, δDwax and δ13Cwax became de-coupled suggesting that the plant wax discharge and their isotope signals were no longer solely controlled by climate; the waxes likely mainly originate from the lowlands and carry an enriched (dry) δD signal but a depleted 13C signature. The depletion of δ13Cwax correlates with the increase of Argan pollen concentration in the record. The period between ~700 and 900 CE coincides with the Arabization of Morocco which had an impact on the demographic composition of the country leading to new agricultural habits and, as a result, on the land-use triggering a higher erosion of lowland material by the Souss River.
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Wang, Zheng, Zhisheng An, Zhonghui Liu, Xiaoke Qiang, Fan Zhang, and Weiguo Liu. "Hydroclimatic variability in loess δDwax records from the central Chinese Loess Plateau over the past 250 ka." Journal of Asian Earth Sciences 155 (April 2018): 49–57. http://dx.doi.org/10.1016/j.jseaes.2017.11.008.
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Burdanowitz, Nicole, Lydie Dupont, Matthias Zabel, and Enno Schefuß. "Holocene hydrologic and vegetation developments in the Orange River catchment (South Africa) and their controls." Holocene 28, no. 8 (April 23, 2018): 1288–300. http://dx.doi.org/10.1177/0959683618771484.
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The summer rainfall zone (SRZ) in the South African interior experienced pronounced hydrological and vegetation changes during the Holocene inferred to be driven mainly by shifts in atmospheric and oceanic circulations systems. The exact mechanisms controlling these changes are still debated. To gain better insights into the Holocene environmental changes in the South African SRZ and their driving factors, we analysed compound-specific carbon and hydrogen isotopes of plant wax n-alkanes (δ13Cwax and δDwax) from a marine sediment core covering the last 9900 years. The core has been recovered offshore the mouth of the Orange River, predominantly draining the South African summer rainfall region. Our data indicate a dry early Holocene and a gradual increase of wetter conditions with a higher abundance of C4 vegetation towards the middle Holocene. Wettest conditions occurred around 3900 cal. yr BP. The last 3900 years were characterised by a gradual aridification overlain by variable wetter conditions. During the ‘Little Ice Age’ (LIA: ca. 640–310 cal. yr BP), relatively dry conditions with elevated C4 plant contributions occurred. This opposite behaviour, that is, more C4 plant contribution during drier conditions compared to the remainder of the Holocene, points towards an influence of winter rainfall in the lower Orange River catchment during the late-Holocene and a decline in summer rainfall. We emphasise the importance of changes in the latitudinal insolation gradient (LIG) as a potentially important controlling mechanism for hydrologic and vegetation changes in the SRZ.
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Miller, Charlotte, Jemma Finch, Trevor Hill, Francien Peterse, Marc Humphries, Matthias Zabel, and Enno Schefuß. "Late Quaternary climate variability at Mfabeni peatland, eastern South Africa." Climate of the Past 15, no. 3 (June 27, 2019): 1153–70. http://dx.doi.org/10.5194/cp-15-1153-2019.
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Abstract. The scarcity of continuous, terrestrial, palaeoenvironmental records in eastern South Africa leaves the evolution of late Quaternary climate and its driving mechanisms uncertain. Here we use a ∼7 m long core from Mfabeni peatland (KwaZulu-Natal, South Africa) to reconstruct climate variability for the last 32 000 years (cal ka BP). We infer past vegetation and hydrological variability using stable carbon (δ13Cwax) and hydrogen isotopes (δDwax) of plant-wax n-alkanes and use Paq to reconstruct water table changes. Our results indicate that late Quaternary climate in eastern South Africa did not respond directly to orbital forcing or to changes in sea-surface temperatures (SSTs) in the western Indian Ocean. We attribute the arid conditions evidenced at Mfabeni during the Last Glacial Maximum (LGM) to low SSTs and an equatorward displacement of (i) the Southern Hemisphere westerlies, (ii) the subtropical high-pressure cell, and (iii) the South Indian Ocean Convergence Zone (SIOCZ), which we infer was linked to increased Antarctic sea-ice extent. The northerly location of the high-pressure cell and the SIOCZ inhibited moisture advection inland and pushed the rain-bearing cloud band north of Mfabeni, respectively. The increased humidity at Mfabeni between 19 and 14 cal kyr BP likely resulted from a southward retreat of the westerlies, the high-pressure cell, and the SIOCZ, consistent with a decrease in Antarctic sea-ice extent. Between 14 and 5 cal kyr BP, when the westerlies, the high-pressure cell, and the SIOCZ were in their southernmost position, local insolation became the dominant control, leading to stronger atmospheric convection and an enhanced tropical easterly monsoon. Generally drier conditions persisted during the past ca. 5 cal ka BP, probably resulting from an equatorward return of the westerlies, the high-pressure cell, and the SIOCZ. Higher SSTs and heightened El Niño–Southern Oscillation (ENSO) activity may have played a role in enhancing climatic variability during the past ca. 5 cal ka BP. Our findings highlight the influence of the latitudinal position of the westerlies, the high-pressure cell, and the SIOCZ in driving climatological and environmental changes in eastern South Africa.
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Shevelev, Igor V., Kristijan Ramadan, and Ulrich Hubscher. "The TREX2 3′→ 5′ Exonuclease Physically Interacts with DNA Polymerase δ and Increases Its Accuracy." Scientific World JOURNAL 2 (2002): 275–81. http://dx.doi.org/10.1100/tsw.2002.99.
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Proofreading function by the 3′→ 5′ exonuclease of DNA polymerase δ (pol δ) is consistent with the observation that deficiency of the associated exonuclease can lead to a strong mutation phenotype, high error rates during DNA replication, and ultimately cancer. We have isolated pol δdfrom isotonic (pol δi) and detergent (pol δd) calf thymus extracts. Pol δdhad a 20-fold higher ratio of exonuclease to DNA polymerase than pol δi. This was due to the physical association of the TREX2 exonuclease to pol δd, which was missing from pol δi. Pol δdwas fivefold more accurate than pol δiunder error-prone conditions (1 μM dGTP and 20 dATP, dCTP, and dTTP) in a M13mp2 DNA forward mutation assay, and fourfold more accurate in an M13mp2T90 reversion assay. Under error-free conditions (20 μM each of the four dNTPs), however, both polymerases showed equal fidelity. Our data suggested that autonomous 3′→ 5′ exonucleases, such as TREX2, through its association with pol I can guarantee high fidelity under difficult conditions in the cell (e.g., imbalance of dNTPs) and can add to the accuracy of the DNA replication machinery, thus preventing mutagenesis.
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Wang, Zheng, Weiguo Liu, Hong Wang, Yunning Cao, Jing Hu, Jibao Dong, Hongxuan Lu, Huangye Wang, Meng Xing, and Hu Liu. "New chronology of the Chinese loess-paleosol sequence by leaf wax δD records during the past 800 k.y." Geology, March 26, 2021. http://dx.doi.org/10.1130/g48833.1.
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The Chinese loess-paleosol sequences provide important archives for studying paleoenvironmental changes. However, the lack of independent and accurate time scales hinders the study between loess and other records. Asian stalagmite δ18O records indicate synchronous patterns of paleoprecipitation δ18O over large geographic regions. The record of hydrogen isotopic composition of plant wax (δDwax) in Chinese loess is also controlled by rainwater δD. Both share a common origin. The linear relationship between rainfall δ18O and δD variance provides the basis to tie together chronologies of the same climate event in different records. Here, we show a new loess chronology by correlating chronologies of marker boundaries of the prominent climate chronozones in stalagmite δ18O and summer insolation to the equivalent climate stratigraphy in the loess δDwax sequence. We first developed and tested this novel methodology with data since the last interglacial on a millennial scale, and then applied this approach to the loess δDwax sequence for the past 800 k.y. to improve the traditional chronology based on magnetic susceptibility and grain size. The new δDwax time series provides not only an improved chronology for studying paleoclimate changes during interglacial intervals, it also represents a unique database with which to better understand the links between the Asian monsoon changes in the Chinese loess and other global climate events, especially for the periods prior to 640 ka, for which stalagmite records are not available.
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Yost, Chad L., Rachel L. Lupien, Catherine Beck, Craig S. Feibel, Steven R. Archer, and Andrew S. Cohen. "Orbital Influence on Precipitation, Fire, and Grass Community Composition From 1.87 to 1.38 Ma in the Turkana Basin, Kenya." Frontiers in Earth Science 9 (July 28, 2021). http://dx.doi.org/10.3389/feart.2021.568646.
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The Turkana Basin in northern Kenya and southern Ethiopia has yielded hundreds of hominin fossils and is among the most important localities in the world for studying human origins. High resolution climate and vegetation reconstructions from this region can elucidate potential linkages between hominin evolution and environmental change. Microcharcoal and phytoliths were examined from a 216 m (1.87–1.38 Ma) drill core (WTK13), which targeted paleo-Lake Lorenyang sediments from the Nachukui Formation of the Turkana Basin. A total of 287 samples were analyzed at ∼32–96 cm intervals, providing millennial-scale temporal resolution. To better understand how basin sediments record fire and vegetation from the watershed, the paleorecord was compared with nine modern sediment samples collected from Lake Turkana along a transect of increasing distance from the 1978 to 1979 shoreline. This included vegetation surveys and phytolith production data for species from areas proximal to the basin. We found that phytolith and microcharcoal concentrations decreased predictably moving off shore. However, phytoliths from plants sourced in the Ethiopian Highlands increased moving off shore, likely the result of increased exposure to the Omo River sediment plume. In our down-core study, microcharcoal was well-preserved but phytolith preservation was poor below ∼60 m (∼1.50 Ma). Spectral analysis revealed that microcharcoal often varied at precessional (∼21 kyr) periodicities, and through a correlation with δDwax, linked orbitally forced peaks in precipitation with elevated fire on the landscape. Phytoliths revealed that alternating mesic C4 versus xeric C4 grass dominance likely varied at precessional periodicities as well, but that grass community composition was also mediated by basin geometry. Two high eccentricity intervals of particularly high amplitude and abrupt environmental change were centered at ∼1.72 and 1.50 Ma, with the intervening period experiencing high fire variability. With the switch from lacustrine to fluvial-deltaic deposition at the core site by 1.5 Ma, mesic C4 grasses dominated and fire activity was high. This upper interval correlated to the time interval from which Nariokotome Boy (Homo erectus/ergaster) was discovered 3 km east of our drill site. Phytoliths indicated a seasonally wet and open landscape dominated by xeric C4 grasses, sedges, and other herbaceous plants.
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Zhu, Yi, Yixin Tang, Guonan Zhang, Jie Zhang, Yanjie Li, and Zhuolin Jiang. "Quantitative analysis of superb microvascular imaging for monitoring tumor response to chemoradiotherapy in locally advanced cervical cancer." Frontiers in Oncology 12 (January 4, 2023). http://dx.doi.org/10.3389/fonc.2022.1074173.
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ObjectivesAs an ultrasound (US) image processing method, superb microvascular imaging (SMI) extracts and visualizes flow signals from vessels through advanced clutter suppression technology. We investigated the feasibility of SMI in monitoring treatment response in patients with locally advanced cervical cancer (LACC) undergoing chemoradiotherapy (CRT).MethodsForty-nine patients underwent CRT and received SMI examination at 3 time points: before therapy (baseline), 3 weeks during, and 1 month after CRT. The maximum tumor diameter (Dmax), vascularity index (VI), and their percentage changes (ΔDmax and ΔVI) were calculated. ΔDmax was compared with MRI results as the reference standard.ResultsBased on the MRI findings, 44 were classified as complete response (CR) group and 5 as partial response (PR) group. The Dmax and ΔDmax showed decrease in CR and PR groups at 3 weeks during CRT (P< 0.05), but no significant difference between the two groups (P > 0.05). Compared to the baseline, significant decrease in VI and ΔVI were observed at during and after treatment in the two groups (P< 0.05). Moreover, there were significant differences in VI and ΔVI at 3 weeks during CRT between the CR and PR groups (P< 0.05). ΔVI at 3 weeks during CRT showed a better predictive performance for responder prognosis than VI (AUC = 0.964, AUC = 0.950, respectively, P = 0.001), with a cut-off value of 41.6% yielding 100% sensitivity and 86.4% specificity.ConclusionsThe SMI parameters (VI and ΔVI) have potential for monitoring treatment response in LACC.
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Li, Zhen, Kehui Chen, Zhenyu Yang, Qingyuan Zhu, Xiaojing Yang, Zhaobin Li, and Jie Fu. "A personalized DVH prediction model for HDR brachytherapy in cervical cancer treatment." Frontiers in Oncology 12 (August 30, 2022). http://dx.doi.org/10.3389/fonc.2022.967436.
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PurposeAlthough the knowledge-based dose-volume histogram (DVH) prediction has been largely researched and applied in External Beam Radiation Therapy, it is still less investigated in the domain of brachytherapy. The purpose of this study is to develop a reliable DVH prediction method for high-dose-rate brachytherapy plans.MethodA DVH prediction workflow combining kernel density estimation (KDE), k-nearest neighbor (kNN), and principal component analysis (PCA) was proposed. PCA and kNN were first employed together to select similar patients based on principal component directions. 79 cervical cancer patients with different applicators inserted was included in this study. The KDE model was built based on the relationship between distance-to-target (DTH) and the dose in selected cases, which can be subsequently used to estimate the dose probability distribution in the validation set. Model performance of bladder and rectum was quantified by |ΔD2cc|, |ΔD1cc|, |ΔD0.1cc|, |ΔDmax|, and |ΔDmean| in the form of mean and standard deviation. The model performance between KDE only and the combination of kNN, PCA, and KDE was compared.Result20, 30 patients were selected for rectum and bladder based on KNN and PCA, respectively. The absolute residual between the actual plans and the predicted plans were 0.38 ± 0.29, 0.4 ± 0.32, 0.43 ± 0.36, 0.97 ± 0.66, and 0.13 ± 0.99 for |ΔD2cc|, |ΔD1cc|, |ΔD0.1cc|, |ΔDmax|, and |ΔDmean| in the bladder, respectively. For rectum, the corresponding results were 0.34 ± 0.27, 0.38 ± 0.33, 0.63 ± 0.57, 1.41 ± 0.99 and 0.23 ± 0.17, respectively. The combination of kNN, PCA, and KDE showed a significantly better prediction performance than KDE only, with an improvement of 30.3% for the bladder and 33.3% for the rectum.ConclusionIn this study, a knowledge-based machine learning model was proposed and verified to accurately predict the DVH for new patients. This model is proved to be effective in our testing group in the workflow of HDR brachytherapy.