Relevant bibliographies by topics / Zscan4

Academic literature on the topic 'Zscan4'

Author: Grafiati
Published: 9 March 2023

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Journal articles on the topic "Zscan4"

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Srinivasan, Rajini, Nataliya Nady, Neha Arora, Laura J. Hsieh, Tomek Swigut, Geeta J. Narlikar, Mark Wossidlo, and Joanna Wysocka. "Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage." Science Advances 6, no. 12 (March 2020): eaaz9115. http://dx.doi.org/10.1126/sciadv.aaz9115.

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Zinc finger protein Zscan4 is selectively expressed in mouse two-cell (2C) embryos undergoing zygotic genome activation (ZGA) and in a rare subpopulation of embryonic stem cells with 2C-like features. Here, we show that Zscan4 specifically recognizes a subset of (CA)n microsatellites, repeat sequences prone to genomic instability. Zscan4-associated microsatellite regions are characterized by low nuclease sensitivity and high histone occupancy. In vitro, Zscan4 binds nucleosomes and protects them from disassembly upon torsional strain. Furthermore, Zscan4 depletion leads to elevated DNA damage in 2C mouse embryos in a transcription-dependent manner. Together, our results identify Zscan4 as a DNA sequence–dependent microsatellite binding factor and suggest a developmentally regulated mechanism, which protects fragile genomic regions from DNA damage at a time of embryogenesis associated with high transcriptional burden and genomic stress.
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Ko, Shigeru B. H., Sakiko Azuma, Yukihiro Yokoyama, Akiko Yamamoto, Kazuhiro Kyokane, Shumpei Niida, Hiroshi Ishiguro, and Minoru S. H. Ko. "Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas." American Journal of Physiology-Gastrointestinal and Liver Physiology 304, no. 12 (June 15, 2013): G1103—G1116. http://dx.doi.org/10.1152/ajpgi.00299.2012.

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We have recently identified the zinc finger and SCAN domain containing 4 (Zscan4), which is transiently expressed and regulates telomere elongation and genome stability in mouse embryonic stem (ES) cells. The aim of this study was to examine the expression of ZSCAN4 in the adult pancreas and elucidate the role of ZSCAN4 in tissue inflammation and subsequent regeneration. The expression of ZSCAN4 and other progenitor or differentiated cell markers in the human pancreas was immunohistochemically examined. Pancreas sections of alcoholic or autoimmune pancreatitis patients before and under maintenance corticosteroid treatment were used in this study. In the adult human pancreas a small number of ZSCAN4-positive (ZSCAN4+) cells are present among cells located in the islets of Langerhans, acini, ducts, and oval-shaped cells. These cells not only express differentiated cell markers for each compartment of the pancreas but also express other tissue stem/progenitor cell markers. Furthermore, the number of ZSCAN4+cells dramatically increased in patients with chronic pancreatitis, especially in the pancreatic tissues of autoimmune pancreatitis actively regenerating under corticosteroid treatment. Interestingly, a number of ZSCAN4+cells in the pancreas of autoimmune pancreatitis returned to the basal level after 1 yr of maintenance corticosteroid treatment. In conclusion, coexpression of progenitor cell markers and differentiated cell markers with ZSCAN4 in each compartment of the pancreas may indicate the presence of facultative progenitors for both exocrine and endocrine cells in the adult pancreas.
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Dan, Jiameng, Zhongcheng Zhou, Fang Wang, Hua Wang, Renpeng Guo, David L. Keefe, and Lin Liu. "Zscan4 Contributes to Telomere Maintenance in Telomerase-Deficient Late Generation Mouse ESCs and Human ALT Cancer Cells." Cells 11, no. 3 (January 28, 2022): 456. http://dx.doi.org/10.3390/cells11030456.

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Proper telomere length is essential for indefinite self-renewal of embryonic stem (ES) cells and cancer cells. Telomerase-deficient late generation mouse ES cells and human ALT cancer cells are able to propagate for numerous passages, suggesting telomerase-independent mechanisms responding for telomere maintenance. However, the underlying mechanisms ensuring the telomere length maintenance are unclear. Here, using late generation telomerase KO (G4 Terc-/-) ESCs as a model, we show that Zscan4, highly upregulated in G4 Terc-/- ESCs, is responsible for the prolonged culture of these cells with stably short telomeres. Mechanistically, G4 Terc-/- ESCs showed reduced levels of DNA methylation and H3K9me3 at Zscan4 promoter and subtelomeres, which relieved the expression of Zscan4. Similarly, human ZSCAN4 was also derepressed by reduced H3K9me3 at its promoter in ALT U2 OS cells, and depletion of ZSCAN4 significantly shortened telomeres. Our results define a similar conserved pathway contributing to the telomere maintenance in telomerase-deficient late generation mESCs and human ALT U2OS cancer cells.
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Brown, Helen A., Charles A. C. Williams, Houjiang Zhou, Diana Rios-Szwed, Rosalia Fernandez-Alonso, Saria Mansoor, Liam McMulkin, et al. "An ERK5–KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells." Biochemical Journal 478, no. 23 (December 6, 2021): 4119–36. http://dx.doi.org/10.1042/bcj20210646.

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The ERK5 MAP kinase signalling pathway drives transcription of naïve pluripotency genes in mouse Embryonic Stem Cells (mESCs). However, how ERK5 impacts on other aspects of mESC biology has not been investigated. Here, we employ quantitative proteomic profiling to identify proteins whose expression is regulated by the ERK5 pathway in mESCs. This reveals a function for ERK5 signalling in regulating dynamically expressed early embryonic 2-cell stage (2C) genes including the mESC rejuvenation factor ZSCAN4. ERK5 signalling and ZSCAN4 induction in mESCs increases telomere length, a key rejuvenative process required for prolonged culture. Mechanistically, ERK5 promotes ZSCAN4 and 2C gene expression via transcription of the KLF2 pluripotency transcription factor. Surprisingly, ERK5 also directly phosphorylates KLF2 to drive ubiquitin-dependent degradation, encoding negative feedback regulation of 2C gene expression. In summary, our data identify a regulatory module whereby ERK5 kinase and transcriptional activities bi-directionally control KLF2 levels to pattern 2C gene transcription and a key mESC rejuvenation process.
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Ruebel, Meghan L., Kailey A. Vincent, Peter Z. Schall, Kai Wang, and Keith E. Latham. "SMCHD1 terminates the first embryonic genome activation event in mouse two-cell embryos and contributes to a transcriptionally repressive state." American Journal of Physiology-Cell Physiology 317, no. 4 (October 1, 2019): C655—C664. http://dx.doi.org/10.1152/ajpcell.00116.2019.

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Embryonic genome activation (EGA) in mammals begins with transient expression of a large group of genes (EGA1). Importantly, entry into and exit from the 2C/EGA state is essential for viability. Dux family member genes play an integral role in EGA1 by activating other EGA marker genes such as Zscan4 family members. We previously reported that structural maintenance of chromosomes flexible hinge domain-containing protein 1 ( Smchd1) is expressed at the mRNA and protein levels in mouse oocytes and early embryos and that elimination of Smchd1 expression inhibits inner cell mass formation, blastocyst formation and hatching, and term development. We extend these observations here by showing that siRNA knockdown of Smchd1 in zygotes results in overexpression of Dux and Zscan4 in two-cell embryos, with continued overexpression of Dux at least through the eight-cell stage as well as prolonged expression of Zscan4. These results are consistent with a role for SMCHD1 in promoting exit from the EGA1 state and establishing SMCHD1 as a maternal effect gene and the first chromatin regulatory factor identified with this role. Additionally, bioinformatics analysis reveals that SMCHD1 also contributes to the creation of a transcriptionally repressive state to allow correct gene regulation.
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Zalzman, Michal, Geppino Falco, Lioudmila V. Sharova, Akira Nishiyama, Marshall Thomas, Sung-Lim Lee, Carole A. Stagg, et al. "Zscan4 regulates telomere elongation and genomic stability in ES cells." Nature 464, no. 7290 (March 24, 2010): 858–63. http://dx.doi.org/10.1038/nature08882.

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Lee, Sung-Lim, Geppino Falco, Ilaria Stanghellini, Uwem C. Bassey, Toshio Hamatani, and Minoru S. H. Ko. "Zscan4: A NOVEL GENE EXPRESSED EXCLUSIVELY IN LATE 2-CELL EMBRYOS." Biology of Reproduction 77, Suppl_1 (July 1, 2007): 79. http://dx.doi.org/10.1093/biolreprod/77.s1.79b.

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Portney, Benjamin A., Michal Arad, Aditi Gupta, Robert A. Brown, Raju Khatri, Phyo Nay Lin, Andrea M. Hebert, et al. "ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype." Oncogene 39, no. 26 (June 2020): 4970–82. http://dx.doi.org/10.1038/s41388-020-1333-1.

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Tagliaferri, Daniela, Maria Teresa De Angelis, Nicola Antonino Russo, Maria Marotta, Michele Ceccarelli, Luigi Del Vecchio, Mario De Felice, and Geppino Falco. "Retinoic Acid Specifically Enhances Embryonic Stem Cell Metastate Marked by Zscan4." PLOS ONE 11, no. 2 (February 3, 2016): e0147683. http://dx.doi.org/10.1371/journal.pone.0147683.

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Nakai-Futatsugi, Yoko, and Hitoshi Niwa. "Zscan4 Is Activated after Telomere Shortening in Mouse Embryonic Stem Cells." Stem Cell Reports 6, no. 4 (April 2016): 483–95. http://dx.doi.org/10.1016/j.stemcr.2016.02.010.

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Dissertations / Theses on the topic "Zscan4"

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Kumpfmueller, Benjamin. "Control of embryonic stem cell fate : the role of phosphoinositide 3-kinase signalling and Zscan4." Thesis, University of Bath, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550614.

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Embryonic stem (ES) cells have the remarkable ability to differentiate into all cells comprising the three germ layers of the developing embryo. It is this pluripotency that makes them attractive for use in regenerative medicine. However, in order to harness this potential, we must understand the molecular mechanisms regulating the ability of ES cells to self-renew and thereby generate identical pluripotent daughter ES cells. The Welham laboratory has previously described a requirement for PI3K signalling in maintaining self-renewal of murine ES (mES) (Paling et al., 2004; Storm et al., 2007). To identify the molecular mechanisms involved in regulating mES cell self-renewal downstream of PI3K signalling, an Affymetrix microarray screen was carried out prior to the start of this PhD. For the screen, mES cells were grown in the presence of LIF and treated with the reversible PI3K inhibitor LY294002 (LY) or a DMSO control for 24, 48 and 72 hours. A total of 646 statistically significant transcriptional changes were detected and subsequently divided into 12 clusters using k-means clustering. Experiments using pharmacological inhibitors suggest that genes within the same cluster are regulated by common mechanisms. To identify potential candidates involved in regulation of mES cell pluripotency, further analyses concentrated on transcription factors and genes with unknown functions. In our microarray data Zscan4c, a member of a SCAN-domain containing Zinc finger protein family, is one of the earliest down-regulated probe-sets. Loss-of-function experiments using siRNA approaches highlight a role for Zscan4 downstream of PI3Ks in regulation of ES cell self-renewal. Immunohistochemical staining of cells overexpressing Zscan4c showed nuclear accumulation of the protein. This, together with the fact that Zscan4c was mainly detectable in the nuclear protein fraction, strengthens a role of Zscan4c in transcriptional regulation. Potential Zscan4c protein interaction partners were identified by applying a combined immunoprecipitation (IP) - mass spectrometry strategy. Interestingly, the majority of potential Zscan4c interacting proteins identified are associated with functions related to transcriptional regulation and DNA damage response, all characteristics linked with Zscan4. Furthermore, the Class IA PI3K catalytic isoforms were genetically activated in mES cells, and liberation of the requirement for LIF was found upon over-expression of an activated p110 catalytic subunit.
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GNOCCHI, ANDREA. "UNDERSTANDING THE IMPACT OF REPLICATION STRESS ON THE EXPRESSION OF EARLY GENES IN MOUSE EMBRYONIC STEM CELLS." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/814703.

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Embryonic stem cells (ESCs) are characterized by a rapid cell cycle, which leads to high replication stress (RS) in otherwise unperturbed conditions. The mechanisms that ESCs adopt to cope with their endogenous RS, however, remain to this day elusive. In our recent work we demonstrated that the activation of the checkpoint kinase ATR in response to RS leads to a broad activation of 2-cells stage specific genes in mouse ESCs. This response relies on the up-regulation of Dux, a transcription factor encoded in a macrosatellite sequence repeated in tandem. Dux is repressed by variant Polycomb repressive complex 1 (vPRC1) in unperturbed ESCs, independently from PRC2 presence. Here we demonstrate that RS causes a major rearrangement of both PRC1 and PRC2 in ESCs nuclei, resulting in a major loss of both repressive marks in correspondence to target promoters. Surprisingly, Dux undergoes an increase in vPRC1 occupancy upon RS in an ATR-dependent manner, possibly due to PRC1 involvement in the replication of highly repeated DNA sequences. More interestingly, Dux activation upon RS requires the presence of PRC2. This result is possibly due to PRC2 proved role in the processing of stalled replication forks, which are the main structure signaling RS. In agreement to this data, also the fork remodeling translocases HLTF and ZRANB3 displayed an effect in Dux activation following RS. Taken together, our results show that the up-regulation of 2-cells genes following RS not only requires ATR activation, but also downstream remodeling processes.
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MEJIA, Hans Anderson Garcia. "Estudo de propriedades ópticas não-lineares da água em 1,56μm." Universidade Federal de Pernambuco, 2008. https://repositorio.ufpe.br/handle/123456789/6305.

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Made available in DSpace on 2014-06-12T18:03:53Z (GMT). No. of bitstreams: 2 arquivo4184_1.pdf: 2850489 bytes, checksum: 55544e4b2cf6c099167866e969860882 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2008
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Neste trabalho foram estudadas as propriedades ópticas não lineares de terceira ordem e propriedades térmicas da água para excitação de comprimento de onda perto da banda de absorção em 1560 nm. As experiências foram feitas usando um laser com pulsos de fentossegundos, largura temporal de 65 fs e taxa de repetição da ordem de 50MHz. A análise do sinal e da magnitude da não linearidade foi feita usando uma nova técnica (TM-EZ scan: Thermally Managed Eclipse Z-scan). Esta técnica é uma combinação da técnica de varredura Z com eclipse (EZ - scan) com a técnica de varredura Z de controle da não linearidade de origem térmica. A nova técnica com a qual se ganhou em sensibilidade, permite a caracteriza¸c ao simult anea de efeitos n ao lineares acumulativos e n ao acumulativos, utilizando intensidade de pico muito baixas. Propriedades t´ermicas foram estudadas com a t´ecnica Z scan de controle da n ao linearidade de origem t´ermica. De nosso estudo, conclu´ımos que um par ametro relevante que realmente afeta uma medida de varredura Z com taxa de repeti¸c ao alta ´e o processo de absor¸c ao. O valor do ´ındice de refra¸c ao n ao linear n2, da ordem de 10−15 cm2 W foi determinado para a ´agua. Experi encias complementares com CS2 e metanol foram tamb´em realizadas visando compara¸c oes com os resultados obtidos para a ´agua. O valor encontrado para a difusividade t´ermica da ´agua ´e da mesma ordem de grandeza que o encontrado na literatura.
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Books on the topic "Zscan4"

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Bellmann, Ferdinand. Das Zeughaus im Grossen Zschand in der Sächsischen Schweiz. Freital: Heimtbuchverlag Bellmann, 2018.

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Kletterführer Elbsandsteingebirge, Sächsische Schweiz, Ostteil: Schmilkaer Gebiet, Affensteine, Kleiner Zschand, Grosser Zschand, Wildensteiner Gebiet, Hinterhermsdorfer Gebiet. 2nd ed. Berlin: Sportverlag, 1985.

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Conference papers on the topic "Zscan4"

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Lee, Kyungwoo, and Lauren Gollahon. "Abstract 2047: The interaction of ZSCAN4 with TRF1: Effects on regulation of telomere elongation in cancer cells." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2047.

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lee, kyungwoo. "Abstract 579: The interaction of ZSCAN4 with TRF1: effects on regulation of telomere elongation in cancer cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-579.

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Hua Jin, Weijun Hong, Li-Gong Zhang, and De-Zhen Shen. "Study on third-order nonlinear of polydiacetylene langmuir-schaefer film by ZSCAN technique with femtosecond pulse laser." In 2012 IEEE International Conference on Oxide Materials for Electronic Engineering (OMEE). IEEE, 2012. http://dx.doi.org/10.1109/omee.2012.6343691.

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