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Author: Grafiati
Published: 14 March 2023

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1

Bhattacharya, Udayan, Mohammad Kamran, Maroua Manai, Massimo Cristofanilli, and Tan A. Ince. "Cell-of-Origin Targeted Drug Repurposing for Triple-Negative and Inflammatory Breast Carcinoma with HDAC and HSP90 Inhibitors Combined with Niclosamide." Cancers 15, no. 2 (January 4, 2023): 332. http://dx.doi.org/10.3390/cancers15020332.

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We recently identified a cell-of-origin-specific mRNA signature associated with metastasis and poor outcome in triple-negative carcinoma (TNBC). This TNBC cell-of-origin signature is associated with the over-expression of histone deacetylases and zinc finger protein HDAC1, HDAC7, and ZNF92, respectively. Based on this signature, we discovered that the combination of three drugs (an HDAC inhibitor, an anti-helminthic Niclosamide, and an antibiotic Tanespimycin that inhibits HSP90) synergistically reduces the proliferation of the twelve tested TNBC cell lines. Additionally, we discovered that four out of five inflammatory breast carcinoma cell lines are sensitive to this combination. Significantly, the concentration of the drugs that are used in these experiments are within or below clinically achievable dose, and the synergistic activity only emerged when all three drugs were combined. Our results suggest that HDAC and HSP90 inhibitors combined with the tapeworm drug Niclosamide can achieve remarkably synergistic inhibition of TNBC and IBC. Since Niclosamide, HDAC, and HSP90 inhibitors were approved for clinical use for other cancer types, it may be possible to repurpose their combination for TNBC and IBC.
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2

Wang, Luqun, Qiong Liu, Hao Li, Li Lizhen, and Xin Wang. "The Establishment of Bortezomib Resistant Myeloma Cell Line KM3/BTZ and Explore the Resistance Mechanism." Blood 124, no. 21 (December 6, 2014): 5226. http://dx.doi.org/10.1182/blood.v124.21.5226.5226.

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Abstract Background: Multiple myeloma (MM) is an incurable B-cell malignancy resulting in significant morbidity and mortality, the incidence of second place in hematological malignancies. The proteasome inhibitor bortezomib inhibits IkappaB degradation, prevents NF-kappaB activation, and induces apoptosis in MM cells, has become first-line drug to MM. Despite its promising activity in traditional chemoresistant myeloma patients, however, some patients are resistant or become refractory to bortezomib. Chauhan D et al reported that Blockade of Hsp27 overcomes bortezomib resistance in lymphoma cells (Chauhan D et al., Cancer Re, 2003). However, bortezomib resistance mechanisms in MM remain controversial, the molecular basis of this reduced responsiveness is currently not fully understood. Objective: To establish a bortezomib-resistant cell line KM3 /BTZ of MM, then search for genes related to bortezomib resistance phenotype by analyzing the differential gene expression patterns with cDNA microarray,and explain the mechanism of bortezomib-resistant multiple myeloma. Methods: Bortezomib-resistant KM3/BTZ cell line was generated by increasing concentration of bortezomib to induce KM3 cells in vitro. MTT assay was employed to detect the cytotoxic effect on KM3 and KM3/BTZ cells. The cells apoptosis were analyzed by flow cytometry. We detect the gene expression profile changes between KM3/BTZ and its parent cell line KM3 cells by CDNA microarray. Combining of molecular annotation system MAS3.0 software and detailed analysis of documented resistance genes were used to analyze the data. Specific differentially-expressed genes were chosen for further verification using real-time RT-PCR. The expression of multi-drug resistance 1(MDR-1) gene mRNA was determined by RT-PCR. Results: The KM3/BTZ cell line was established successfully. Bortezomib resistance index values were significantly higher in KM3/BTZ (IC50 =351.2±3.51ng /ml) when compared to KM3 cells (IC50 = 17.8±1.03ng /ml),and the resistance index is 19.7 (P< 0.05). Through gene expression profiling filtering, compared with KM3,770 significantly differently expressed genes were screened out in the KM3/BTZ cell line, of which up and down regulated genes were 287 and 383 respectively, in which heat shock protein family gene HSPB2 was significantly up-regulated (Ratio=14.7455). Downregulated gene list in KM3/BTZ cell line included transcriptional regulators like ZNF family proteins (Tab 1). Upregulated genes in KM3/BTZ cell line included signal transduction related genes like MS4A family protein (Tab 1) also transcriptional regulators like ZNF family proteins (Tab 1). The expression trend of eight genes for further verification was almost consistent with the microarray, excepting gene of JUN (Fig 1). The expression of MDR-1 mRNA was not observed in either resistant or parental cells (Fig 2). Conclusion: We have successfully established bortezomib-resistant cell line KM3/BTZ. MDR-1 was not involved in bortezomib-resistant multiple myeloma cells.HSPB2, ZNF and MS4A family genes are probably related to bortezomib resistance in KM3/BTZ cells. Our results suggest that they may be new targets to overcome resistance to bortezomib in patients with MM. Table 1. ZNF and MS4A family gene expression in KM3/BTZ and KM3 cells Gene B signal* B detection* A signal* A detection* BvsA signal log ratio* BvsA change* ZNF711 85.08 P 206.16 P 0.41269 D ZNF92 6.75 P 14.57 P 0.46328 D ZNF704 10.7 A 26.78 P 0.39955 D ZNF492 7.08 P 3.48 P 2.03448 I ZNF532 87.93 P 43.54 A 2.01952 I ZNF594 10.25 P 4.63 P 2.21382 I ZNF789 269.79 P 97.3 P 2.77276 I ZNF506 330.36 P 149.48 P 2.21006 I MS4A3 1721.58 P 145.3 P 11.84845 I MS4A4A 2688.23 P 100.8 P 26.66895 I MS4A6A 141.96 P 56.47 M 2.513901 I MS4A1 49.02 P 53.11 P 0.92299 NC P: High expression; A: Low expression; M:Marginally D: Decrease; I: Increase; NC: No change *: A:KM3; B: KM3/BTZ Figure 1 Figure 1. Correlations of gene expression changes between oligonueleotide Microarray and qRT-PCR, showing change of selected gene in KM3/BTZ compared with KM3.The Y-axis indicates the log2 transformed ratio of mRNA expression. Figure 2 Figure 2. The expression level of MDR-1 mRNA in KM3 and KM3/BTZ and K562/A cell lines. M: DNA Marker; 1-2: K562/A cell line; 3-4: KM3cell line; 5-6: KM3/BTZ cell line Disclosures No relevant conflicts of interest to declare.
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3

Lee, Il-Kwon, Jeong-Hwa Choi, Yu Ra Lee, Yeo-Kyeoung Kim, Hee Nam Kim, Kyeong-Soo Park, Je-Jung Lee, et al. "A Single Nucleotide Polymorphism and Its Haplotype of ZNF42 Transcriptional Modulator Gene Predisposes Individuals to High-Risk Acute Myelogenous Leukemia (AML)." Blood 106, no. 11 (November 16, 2005): 4248. http://dx.doi.org/10.1182/blood.v106.11.4248.4248.

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Abstract ZNF42 (MZF-1 or Human Zinc finger protein 42) is a hematopoietic transcription factor regulating the differentiation and proliferation of myeloid cells. ZNF42 belongs to the Krupple-class zinc finger protein, which is expressed in myeloid progenitor cells. As a transcriptional regulator it has been found to be pivotal in hematopoietic development, especially in granulopoiesis. ZNF42 is a bi-functional transcriptional regulator, by repressing transcription in non-hematopoietic cells, but trans-activating hematopoiesis-related genes. Despite the important role of ZNF42 in differentiation and proliferation in the myeloid lineage cells, molecular epidemiologic studies of ZNF42 have not been conducted. In this case-control study, we conducted a comprehensive analysis of the genomic region of ZNF42, including SNP discovery by re-sequencing of the promoter and exon-encompassing regions, haplotype construction and construction of linkage disequilibrium (LD) map and comparison LD structure among four different populations data from the International HapMap project. In total, 275 de novo AML patients plus age- and sex-matched controls were recruited and four coding non-synonymous SNPs were genotyped by Pyrosequencing for this study. All genotypes frequencies were in Hardy-Weinberg equilibrium. A non-synonymous SNP (G/A altering amino acid R51H) revealed strong association with increased susceptibility to AML. Relative to individuals with the GG genotype, those with the A allele (AA + AG) had a 4.8-fold (95% CI, 3.3–7.0) (p=4.111e-17) risk of development of AML. Also four common (&gt; 5% frequency, cumulative frequency of over 96%) haplotypes were identified and the frequencies of the common haplotypes predicted were similar between cases and controls. When we studied if there is haplotype-based association to examine the contribution of common genetic variation at the ZNF42 locus to AML risk among Korean, two haplotypes (G-G and A-G from R51H-R130Q) showed statistically significant association.. These results suggest that ZNF42 variants and its haplotypes are significantly associated with increased susceptibility to AML.
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Hou, Zhao Xia, Zhao Lu Xue, Shao Hong Wang, Xiao Dan Hu, Hao Ran Lu, Chang Lei Niu, Hao Wang, Cai Wang, and Yin Zhou. "Thermal Stability and Structure of Tellurite Glass." Key Engineering Materials 512-515 (June 2012): 994–97. http://dx.doi.org/10.4028/www.scientific.net/kem.512-515.994.

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Oxyfluoride tellurite glass with the composition of TeO2-AlF3-LaF3-ZnO/ZnCl2/ZnF2 was prepared successfully. The thermal stability and structure of TeO2-AlF3-LaF3 system tellurite glass were studied bySubscript text DSC and IR spectra. The results indicated that glass transition temperature of TeO2-AlF3-LaF3-ZnO/ZnCl2/ZnF2 glass was higher than that of (1-x)TeO2-xAlF3 (x=10%, 20%, 30%, 40%, 50%, in mol%) binary glass system slightly. A small number of ZnF2/ZnCl2/ZnO (5mol%) improved glass thermal stability. After adding 5mol% ZnF2/ZnO/ZnCl2 into fluoride tellurite glass respectively, glass transition temperature increased in turn. The introduction of 5mol% different zinc compounds had a little impact on the glass network structure.
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Elsayed, E. Mostafa, Mohamed M. Rashad, H. F. Y. Khalil, M. R. Hussein, M. M. B. El-Sabbah, and I. A. Ibrahim. "Electrochemical Performance of Nanocrystalline Zinc Ferrite Films Synthesized Using Electrodeposition." Key Engineering Materials 835 (March 2020): 1–6. http://dx.doi.org/10.4028/www.scientific.net/kem.835.1.

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Nanocrystalline spinel zinc ferrite ZnFe2O4 thin film has been studied and synthesized via the electrodeposition-anodization process. Electrodeposited ZnFe2 alloys were obtained from aqueous sulphate bath. The resulted alloys were electrochemically oxidized in strong alkaline solution (1 M KOH) at room temperature to the analogous hydroxides. The electroanodized ZnFe2 alloy film was annealed in air at 400 °C for 2 h to get the required zinc ferrite. The electrochemical factors controlling of the electrodeposition of ZnFe2 alloys such as the bath temperature, agitation, the current density were studied and optimized. The crystal structure, crystal size and microstructure of the produced ferrites were investigated using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The deposited film was mainly composed of ZnFe2O4 based on XRD studies. The produced film had a spinel structure and the crystallite size was 4.9 nm. SEM micrograph of the resulted zinc ferrite particles shows compact crystallites shapes and agglomerated chains with smallest semicircular particles like morphology.
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Zhang, Ye, and Hong Bing Ji. "Preparation of ZnF2 Nano-Particles by Electrochemical Anodization Method." Advanced Materials Research 476-478 (February 2012): 1616–20. http://dx.doi.org/10.4028/www.scientific.net/amr.476-478.1616.

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ZnF2 nano-particles were prepared by electrochemical anodization method at room temperature. Zn foil acted as anode and Pb sheet served as cathode, and the complex solution of NH4F-H2O2-C2H5OH was used as electrolyte. The morphology, composition and crystalline structure of the as-prepared product were characterized by SEM, EDS and XRD techniques. The results showed that the product was rhombic nano-particles with the length of 50-200nm and the width of 50-100nm, the crystalline structure of the product was ZnF2 and ZnO, and the ZnF2 was the dominant component. Effects of NH4F concentration, applied voltage and anodization time on the morphology of the product were investigated.
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7

Maletin, M., E. G. Moshopoulou, and V. V. Srdic. "Magnetic properties of ZnFe2 O4 and In-doped ZnFe2 O4 nanoparticles." physica status solidi (a) 205, no. 8 (May 26, 2008): 1831–34. http://dx.doi.org/10.1002/pssa.200723633.

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Richter, Theresia M. M., Sylvain LeTonquesse, Nicolas S. A. Alt, Eberhard Schlücker, and Rainer Niewa. "Trigonal-Bipyramidal Coordination in First Ammoniates of ZnF2: ZnF2(NH3)3 and ZnF2(NH3)2." Inorganic Chemistry 55, no. 5 (February 19, 2016): 2488–98. http://dx.doi.org/10.1021/acs.inorgchem.5b02837.

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9

Asseid, Fathi M., Jack M. Miller, and James H. Clark. "FT-IR and 29Si, 27Al, and 19F MAS NMR studies of the adsorption of CdF2, ZnF2, and CuF2 onto montmorillonite K10; activity towards Friedel–Crafts alkylation." Canadian Journal of Chemistry 70, no. 9 (September 1, 1992): 2398–404. http://dx.doi.org/10.1139/v92-304.

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ZnF2, CdF2, and CuF2 have been adsorbed onto the surface of montmorillonite K10, and the infrared and 19F, 27Al, and 29Si MAS NMR spectra of the resulting reagents over a range of loadings and activation temperatures have been obtained. CuF2 was observed to attack the SiO2 layer and form the complex CuSiF6, ZnF2 tends to attack the aluminium oxide layer, in which Zn isomorphously replaces Al, and forms AlF3 and AlF4− complexes. The spectroscopic evidence rules out the formation of any Al–F and (or) Si–F species as CdF2 is adsorbed on the surface of montmorillonite K10. The reactivity of MF2–K10 reagents towards the Friedel–Crafts reaction of benzene with benzyl chloride varies from one reagent to another. ZnF2–K10 was observed to be the most reactive and CuF2 was the least reactive.
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Lv, Hao, Yao Ming Ding, Ai Mei Liu, Ju Fang Tong, Xu Nong Yi, and Qian Guang Li. "Nucleation Agent Choice of Li2O–Al2O3–SiO2 Glass Ceramic Having Ideal Micro Spherical Crystal Grains." Advanced Materials Research 311-313 (August 2011): 1332–35. http://dx.doi.org/10.4028/www.scientific.net/amr.311-313.1332.

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The nucleation and crystallization of Li2O-Al2O3-SiO2(LAS) glass ceramic with one(P2O5, TiO2, ZnF2) and two nucleating agents(P2O5+TiO2, P2O5+ZnF2) are investigated by the differential thermal analysis(DTA)，X-ray diffraction(XRD) and the scanning electron microscopy(SEM). Research results show that the LAS glass ceramic with nucleating agent of P2O5can obtain ideal micro spherical crystal grains and the crystallization behavior can be better controlled.
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11

Garcia, Roberto, Robert H. Doremus, Narottarn P. Bansal, Sen-Hou Ko, and Tracey Margraf. "Crystallization of BaF2–ZnF2–YbF3–ThF4 glass." Journal of Materials Research 3, no. 5 (October 1988): 989–95. http://dx.doi.org/10.1557/jmr.1988.0989.

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The crystallizing phases from a BaZn YbTh fluoride glass were a BaYbTh fluoride, ZnF2, and YbF3, as identified with x-ray diffraction and composition-enhanced scanning electron microscopy. Blocky BaYbTh fluoride crystallizes first, at about 450 °C, and ZnF2 excluded from this phase crystallizes at its surfaces. At higher temperatures the BaYbTh fluoride phase decomposes partially to BaThF6 and YbF3 phases. The kinetics and temperatures of crystallization were also followed with differential scanning calorimetry.
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Gong, Wei, Jiancheng Xu, Guangchao Wang, Dan Li, and Qimin Zhan. "ZNF292 suppresses proliferation of ESCC cells through ZNF292/SKP2/P27 signaling axis." Chinese Journal of Cancer Research 33, no. 6 (2021): 637–48. http://dx.doi.org/10.21147/j.issn.1000-9604.2021.06.01.

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13

Alzuhair, A. Z., M. S. Alqahtani, A. J. Alkulib, K. I. Hussein, M. Reben, and E. Yousef. "Structural and shielding properties of the tellurite-tungsten glass matrix with addition zinc fluoride." Chalcogenide Letters 19, no. 3 (April 11, 2022): 187–95. http://dx.doi.org/10.15251/cl.2022.193.187.

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In this study, we reported the radiation protection characteristics of TeO2-WO3-ZnF2 glass systems with different compositions. The composition of the glasses are (0.8 - x) TeO2– 0.2WO3–xZnF2, 0.7TeO2-0.1WO3-0.2-ZnF2 and 0.6TeO2-0.15WO3-0.25ZnF2 (where x = 0.1,0.2,0.3). The radiation shielding parameters including mass attenuation coefficient (MAC), linear attenuation coefficient (LAC), half value layer (HVL), mean free path (MFP), tenth value layer (TVL), effective atomic number (Zeff), effective electron number (Neff), and atomic and electronic cross sections (ACS and ECS) have been determined for the prepared glasses against a broad range of ionizing energy between 0.015 and 15 MeV. The structure of the prepared glasses was investigated by using Raman spectra. It obtained that, the incorporation of WO3 into the TeO2 glass network causes the creation of W–O–W connections, while Te–O–W linkages with greater electronic polarizability improve the glass network's connectedness. The study demonstrates that the TeO2-WO3- ZnF2 glass system can be utilized for radiation protection against ionizing radiation in a variety of medical and technical applications.
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McChesney, J., M. Hetzer, H. Shi, T. Charlton, and D. Lederman. "Growth study of epitaxial FexZn1−xF2 thin films." Journal of Materials Research 16, no. 6 (June 2001): 1769–75. http://dx.doi.org/10.1557/jmr.2001.0244.

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The FexZn1−xF2 alloy has been shown to be a model system for studying the magnetic phase diagram of dilute magnets. Whereas the growth of bulk single crystals with fixed Zn concentrations is difficult, the thin film growth is comparatively simpler and more flexible. To gain an understanding of the growth of FexZn1−xF2 films, a method was developed to grow smooth films at fixed concentrations. This was done by depositing a MgF2 buffer layer on MgF2(001) substrates and then depositing FeF2 and ZnF2 [001]-orientated epitaxial thin films at different temperatures. Surprisingly, the lattice spacing depends strongly on the growth temperature, for 44-nm-thick FeF2 films and 77-nm-thick ZnF2 films. This indicates a significant amount of stress, despite the close lattice match between the films and the MgF2 substrate. Thick alloy samples (approximately 500 nm thick) were grown by co-evaporation from the FeF2 and ZnF2 sources at the ideal temperature determined from the growth study, and their concentration was accurately determined using x-ray diffraction.
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15

Almuqrin, Aljawhara H., and M. I. Sayyed. "Influence of ZnF2 and WO3 on Radiation Attenuation Features of Oxyfluoride Tellurite WO3-ZnF2-TeO2 Glasses Using Phy-X/PSD Software." Materials 15, no. 6 (March 19, 2022): 2285. http://dx.doi.org/10.3390/ma15062285.

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The radiation shielding features of the ternary oxyfluoride tellurite glasses were studied by calculating different shielding factors. The effect of the TeO2, WO3, and ZnF2 on the tested glass system’s attenuating performance was predicted from the examination. The mass attenuation coefficient (µ/ρ) values for the oxyfluoride tellurite glasses depend highly on the concentration of WO3, as well as ZnF2. All the present ZnFWTe1-ZnFWTe5 samples have higher µ/ρ values than that of the pure TeO2 glass at all energies. For the samples with a fixed content of WO3, the replacement of TeO2 by ZnF2 increases the µ/ρ, while for the glasses with a fixed content of TeO2, the replacement of WO3 by ZnF2 results in a decline in the µ/ρ values. The results revealed that ZnFWTe4 has the lowest linear attenuation coefficient (µ) among the oxyfluoride tellurite glasses, whereby it has a slightly higher value than pure TeO2 glass. The maximum effective atomic number (Zeff) is found at 0.284 MeV and varied between 31.75 and 34.30 for the tested glasses; it equaled to 30.29 for the pure TeO2 glass. The half-value layer (HVL) of the glasses showed a gradual decline with increasing density. The pure TeO2 was revealed to have thicker HVL than the selected oxyfluoride tellurite glasses. A 1.901-cm thickness of the sample, ZnFWTe1, is required to decrease the intensity of a photon with an energy of 0.284 MeV to one-tenth of its original, whereas 1.936, 1.956, 2.212, and 2.079 cm are required for glasses ZnFWTe2, ZnFWTe3, ZnFWTe4, and ZnFWTe5, respectively.
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Yao, Zhen, Songbai Xue, and Junxiong Zhang. "Effect of Various Nanoparticles (GaF3, ZnF2, Zn(BF4)2 and Ga2O3) Additions on the Activity of CsF-RbF-AlF3 Flux and Mechanical Behavior of Al/Steel Brazed Joints." Crystals 10, no. 8 (August 7, 2020): 683. http://dx.doi.org/10.3390/cryst10080683.

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In this study, brazing AA6061 to Q235 steel using flame brazing was performed with 70.9 wt.% CsF-0.5 wt.% RbF-28.6 wt.% AlF3 fluxes doped with GaF3, ZnF2, Zn(BF4)2 and Ga2O3 nanoparticles, matched with a Zn-15Al filler metal, and the spreadability of the filler metal and the mechanical properties of brazed joints were investigated at the same time. The results showed suitable amounts of GaF3, ZnF2, Zn(BF4)2 and Ga2O3 doped into the base flux could strengthen the filler metal in wetting and spreading on the surface of aluminum alloy and steel to different degrees. The suitable ranges of GaF3, ZnF2, Zn(BF4)2 and Ga2O3, respectively, were 0.0075–0.01 wt.%, 0.0075–0.01 wt.%, 0.0075–0.01 wt.% and 0.009–0.01 wt.%, and the maximum spreading area was obtained via doping with GaF3. The shear strength of brazed joints reached the peak at 126 MPa when 0.075 wt.% GaF3 was added. Comparative tests proved that the activity of the CsF-RbF-AlF3 flux doped with GaF3 was the best. The reason was that the CsF-RbF-AlF3-GaF3 flux was competent in removing oxides of the base metal and decreasing the interfacial tension, in virtue of the activity of Ga3+ as well as F−.
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Liang, Guojin, Jiaxiong Zhu, Boxun Yan, Qing Li, Ao Chen, Ze Chen, Xiaoqi Wang, et al. "Gradient fluorinated alloy to enable highly reversible Zn-metal anode chemistry." Energy & Environmental Science 15, no. 3 (2022): 1086–96. http://dx.doi.org/10.1039/d1ee03749h.

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Wang, Shu Ya, Yun Ying Fu, Li Ping Dai, and Guo Jun Zhang. "The Etching Reaction and Surface Reconstruction of Bismuth Zinc Niobate Thin Film in SF6/Ar Plasma." Advanced Materials Research 763 (September 2013): 28–32. http://dx.doi.org/10.4028/www.scientific.net/amr.763.28.

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Reactive ion etching (RIE) of bismuth zinc niobate (BZN) thin films using an SF6/Ar plasma has been studied. An optimum process parameters was obtained according to the highest etch rate of 90nm/min. Under this etching condition, the crystal structural properties and surface morphology of the BZN film before and after etching were characterized using X-ray diffraction (XRD), the film showed a surface reconstruction after etching, a cubic pyrochlore structure orientation transition was observed from preferential (222) to (400), and ZnF2 phases were detected. The film surface was chemically analyzed by X-ray photoelectron spectroscopy (XPS) to investigate the reactive ion etching mechanism. A zinc-rich surface was formed because low-volatile ZnF2 residues were difficult to remove.
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Jose, Adon, T. Krishnapriya, Ani Archa Raju, Febina Shah, and P. R. Biju. "Investigations on the fluorescence and radiative parameters of Sm3+ activated BaO-ZnF2-K2O-SiO2-B2O3 glass for laser applications." IOP Conference Series: Materials Science and Engineering 1263, no. 1 (October 1, 2022): 012001. http://dx.doi.org/10.1088/1757-899x/1263/1/012001.

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Present work mainly illustrates the absorbance and fluorescence characteristics of 1 mol% trivalent Samarium ions integrated BaO-ZnF2-K2O-SiO2-B2O3 glass to identify its applicability in photonic materials. With the aid of well renowned Judd Ofelt (J-O) analysis, its corresponding parameters were evaluated by using the absorbance spectrum of the prepared host matrix. Fluorescence spectrum recorded under 400 nm excitation epitomizes 4 luminescent transitions and among these the 4G5/2→6H7/2 transition (598 nm) is observed to be the intense one. Diverse radiative parameters were estimated for that intense emission transition in the Samarium ions integrated BaO+ZnF2+K2O+SiO2+B2O3 glassy system. Comparatively superior fluorescent and radiative features recommend the prepared glassy system for orange lasing applications.
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Jiang, Wen Hong, Ran Dong Yu, and Sheng Lu. "Effect of Compound Fluxes on A-TIG Welding Joint Depth of Cu-Cr-Zr Alloy." Materials Science Forum 749 (March 2013): 133–40. http://dx.doi.org/10.4028/www.scientific.net/msf.749.133.

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A-TIG welding for Cu-Cr-Zr copper alloy was carried out on the eleven pure surface activating fluxes including oxides, fluorides and chlorides on the welding formation and the weld D/W ratio by the means of super depth of field and metallurgical microscope. It was found that the oxides and fluorides could improve welding penetration remarkably, especially with CaF2,ZnF2,SiO2 andCr2O3. Four compound fluxes were chosen from the eleven pure surface activating fluxes, which could increase the penetration and modify the welding shape. An optimized formula composed of the four compounds (CaF2,ZnF2,SiO2 and Cr2O3) was developed by using the formula of uniform design method. It showed that the optimized formula could reach a good weld ability and its weld penetration was 2.5 times more than that of TIG.
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Zhai, Bing, Pinkuan Zhu, Dylan Foyle, Srijana Upadhyay, Alexander Idnurm, and Xiaorong Lin. "Congenic Strains of the Filamentous Form of Cryptococcus neoformans for Studies of Fungal Morphogenesis and Virulence." Infection and Immunity 81, no. 7 (May 13, 2013): 2626–37. http://dx.doi.org/10.1128/iai.00259-13.

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ABSTRACTCryptococcus neoformansis an unconventional dimorphic fungus that can grow either as a yeast or in a filamentous form. To facilitate investigation of genetic factors important for its morphogenesis and pathogenicity, congenicaand α strains for a filamentous form were constructed. XL280 (α) was selected as the background strain because of its robust ability to undergo the morphological transition from yeast to the filamentous form. TheMATaallele from a sequenced strain JEC20 was introgressed into the XL280 background to generate the congenicaand α pair strains. The resulting congenic strains were then used to test the impact of mating type on virulence. In both the inhalation and the intravenous infection models of murine cryptococcosis, the congenicaand α strains displayed comparable levels of high virulence. Thea-α coinfections displayed equivalent virulence to the individualaor α infections in both animal models. Further analyses of the mating type distribution ina-α coinfected mice suggested no influence ofa-α interactions on cryptococcal neurotropism, irrespective of the route of inoculation. Furthermore, deletion or overexpression of a known transcription factor, Znf2, in XL280 abolished or enhanced filamentation and biofilm formation, consistent with its established role. Overexpression of Znf2 in XL280 led to attenuation of virulence and a reduced abundance in the brain but not in other organs, suggesting that Znf2 might interfere with cryptococcal neurotropism upon extrapulmonary dissemination. In summary, the congenic strains provide a new resource for the exploration of the relationship inCryptococcusbetween cellular morphology and pathogenesis.
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Chatterji, Tapan, Mohamed Zbiri, and Thomas C. Hansen. "Negative thermal expansion in ZnF2." Applied Physics Letters 98, no. 18 (May 2, 2011): 181911. http://dx.doi.org/10.1063/1.3588414.

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Chen, Wei, Yucheng Wang, Yoko Abe, Lukas Cheney, Bjarne Udd, and Yi-Ping Li. "Haploinsuffciency for Znf9 in Znf9+/− Mice Is Associated with Multiorgan Abnormalities Resembling Myotonic Dystrophy." Journal of Molecular Biology 368, no. 1 (April 2007): 8–17. http://dx.doi.org/10.1016/j.jmb.2007.01.088.

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24

Li, Man-tang, Cheng-hong Luo, Peng-jie Xu, and Ya Jin. "Study on Circulating lncRNA Expression Profile in Patients with Cerebral Infarction." Disease Markers 2022 (May 9, 2022): 1–11. http://dx.doi.org/10.1155/2022/3042105.

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To analyze the difference of circulating lncRNA expression profile between the healthy control group and cerebral infarction (CI) patients and to study the epigenetic pathogenesis of CI. Forty patients with acute CI admitted to our hospital from December 2016 to December 2017 were selected as CI group, and 40 healthy people in physical examination center were selected as healthy group. In the CI group, blood samples were taken 5 mL at fasting in the morning (within 72 hours of CI), and the blood samples from healthy group were also taken 5 mL at fasting in the morning. The circulating lncRNA expression profile of serum sample was determined by high-throughput technique, and its difference was analyzed. Bioinformatics technology was used to explore its functional mechanism, and GO, KEGG analysis, and gene expression network were established for lncRNA with significant differences. Next, lnc-ZNF32-1 : 1 and lnc-PCGF5-2 : 1 were selected for further validation of serum lncRNA expression in ACI and NC groups, and ceRNA interaction network analysis, diagnostic specificity, and sensitivity of lnc-ZNF32-1 : 1 and lnc-PCGF5-2 : 1 were conducted. The results showed that compared with the healthy group, there were 512 known lncRNA expressed differentially in the serum of patients with CI, of which 371 were upregulated and 141 were downregulated, and 421 known mRNA expressed differentially, of which 245 were upregulated and 176 downregulated. The differentially expressed mRNA was mainly enriched in 53 gene functions, and the target gene was enriched in the pathways such as HTLV-I infection and pathways in cancer. In addition, the results explored that lnc-ZNF32-1 : 1 and lnc-PCGF5-2 : 1 have potential value for CI diagnosis. In conclusion, the expression profile of lncRNA in CI group was significantly different from that in healthy group, indicating that lncRNA might be closely related to the occurrence, development, and prognosis of CI.
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25

Mulligan, L. M., E. Gardner, and B. A. J. Ponder. "An Sphl polymorphism at the ZNF22 locus." Human Molecular Genetics 1, no. 7 (1992): 551. http://dx.doi.org/10.1093/hmg/1.7.551.

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26

Yamazaki, Hiroki, and Junko Satooka. "Structural and magnetic properties of FeF2(001)/ZnF2(001) and FeF2(110)/ZnF2(110) superlattices." Journal of Physics: Condensed Matter 15, no. 8 (February 18, 2003): 1201–15. http://dx.doi.org/10.1088/0953-8984/15/8/305.

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27

Müller, T., and T. Wieser. "Myotone Dystrophie Typ 2/proximale myotone Myopathie." Nervenheilkunde 23, no. 08 (2004): 447–53. http://dx.doi.org/10.1055/s-0038-1626406.

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ZusammenfassungDie myotone Dystrophie Typ 2 ist eine autosomal-dominant vererbte, multisystemische Erkrankung. Klinische Hauptmerkmale sind proximale Paresen und Atrophien, Myotonie und Katarakt. Eine Vielzahl assoziierter Symptome in wechselnder Ausprägung ist beschrieben worden, darunter Schmerzen der Muskulatur, Erhöhung der CK und der Leberwerte, Glukose-Intoleranz bzw. Diabetes mellitus und andere endokrine Auffälligkeiten, Hörstörungen, kognitive Defizite, Veränderungen der weißen Substanz in der MRT und möglicherweise Herzmuskelbeteiligung. Im Vergleich mit der myotonen Dystrophie Typ 1 (Curschmann-Steinert-Dystrophie) ist der Verlauf deutlich milder. Auslöser ist eine Mutation im ZNF9 Gen auf Chromosom 3. Die Funktion dieses Gens und der Pathomechanismus, der zu dem komplexen Phänotyp dieser Erkrankung führt, ist nicht bekannt. Spekuliert wird, dass toxische RNA-Foci über Beeinflussung der Translation negativ auf ZNF9 und benachbarte Gene wirken. Die Diagnose kann molekulargenetisch durch Nachweis der Mutation gestellt werden. Eine kausale Therapie steht nicht zur Verfügung, neben der Operation der Katarakt steht Physiobzw. Ergotherpie im Vordergrund.
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28

Tripathi, Vijay, Harit Kumar, Anubhav Agarwal, and Leela S. Panchakarla. "Microwave-induced electric discharges on metal particles for the synthesis of inorganic nanomaterials under solvent-free conditions." Beilstein Journal of Nanotechnology 11 (July 13, 2020): 1019–25. http://dx.doi.org/10.3762/bjnano.11.86.

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Microwave irradiation of metals generates electric discharges (arcs). These arcs are used to generate nanoparticles of Cu and Ni and one-dimensional nanorods of CuS, ZnF2, and NiF2 protected with fluorinated amorphous carbon. We have also synthesized reduced graphene oxide and partially rolled graphene by this method.
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Cho, Young-Jae, Takasi Hirakawa, Kazuo Sakiyama, Hiroaki Okamoto, and Yoshihiro Hamakawa. "ZnF2: Gd thin film electroluminescent device." Applied Surface Science 113-114 (April 1997): 705–8. http://dx.doi.org/10.1016/s0169-4332(96)00953-1.

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30

Abd El-Moneim, Amin. "Effect of ZnF2 and WO3 on elastic properties of oxyfluoride tellurite ZnF2–WO3–TeO2glasses: Theoretical analysis." Chinese Journal of Physics 65 (June 2020): 412–23. http://dx.doi.org/10.1016/j.cjph.2020.02.013.

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31

Cui, Hongyuan, Mingwei Zhu, Junhua Zhang, Wenqin Li, Lihui Zou, and Yan Wang. "Identification of Differentially Expressed Genes Associated with Papillary Thyroid Carcinoma." Combinatorial Chemistry & High Throughput Screening 23, no. 6 (October 5, 2020): 546–53. http://dx.doi.org/10.2174/1386207323666200402085832.

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Objective: Next-generation sequencing (NGS) was performed to identify genes that were differentially expressed between normal thyroid tissue and papillary thyroid carcinoma (PTC). Materials & Methods: Six candidate genes were selected and further confirmed with quantitative real-time polymerase chain reaction (qRT-PCR), and immunohistochemistry in samples from 24 fresh thyroid tumors and adjacent normal tissues. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was used to investigate signal transduction pathways of the differentially expressed genes. Results: In total, 1690 genes were differentially expressed between samples from patients with PTC and the adjacent normal tissue. Among these, SFRP4, ZNF90, and DCN were the top three upregulated genes, whereas KIRREL3, TRIM36, and GABBR2 were downregulated with the smallest p values. Several pathways were associated with the differentially expressed genes and involved in cellular proliferation, cell migration, and endocrine system tumor progression, which may contribute to the pathogenesis of PTC. Upregulation of SFRP4, ZNF90, and DCN at the mRNA level was further validated with RT-PCR, and DCN expression was further confirmed with immunostaining of PTC samples. Conclusion: These results provide new insights into the molecular mechanisms of PTC. Identification of differentially expressed genes should not only improve the tumor signature for thyroid tumors as a diagnostic biomarker but also reveal potential targets for thyroid tumor treatment.
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Love, D. R., E. Gardner, and B. A. J. Ponder. "A polymorphic dinucleotide repeat at the ZNF22 locus." Human Molecular Genetics 2, no. 4 (1993): 491. http://dx.doi.org/10.1093/hmg/2.4.491-a.

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33

Shojiya, Masanori, Yoji Kawamoto, Akio Konishi, and Hajimu Wakabayashi. "Preparation of ZnF2 and ZnF2–BaF2 thin films by electron cyclotron resonance plasma-enhanced chemical vapor deposition." Thin Solid Films 358, no. 1-2 (January 2000): 99–103. http://dx.doi.org/10.1016/s0040-6090(99)00716-6.

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34

Bai, Jing, Shu Fang Fu, Sheng Zhou, Li Niu, and Xuan Zhang Wang. "Nonlinear Infrared Transmission through and Reflection off Antiferromagnetic Sandwich." Materials Science Forum 663-665 (November 2010): 995–98. http://dx.doi.org/10.4028/www.scientific.net/msf.663-665.995.

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The reflection and transmission of antiferromagnetic sandwich (SiO2/MnF2/ZnF2), which impacted by third-order nonlinear modification from antiferromagnetic film (MnF2), is analyzed. The obvious effect on the reflection can be observed in the vicinity of the resonant frequency. In order to illustrate the influence of medium on the refection and transmission, the case air/MnF2/air also is considered.
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35

Eremeev, K., L. Basyrova, O. Dymshits, S. Balabanov, A. Belyaev, I. Alekseeva, A. Khubetsov, et al. "Structure and spectral properties of Fe:ZnAl2O4 transparent glass-ceramics and ceramic." Journal of Physics: Conference Series 2086, no. 1 (December 1, 2021): 012138. http://dx.doi.org/10.1088/1742-6596/2086/1/012138.

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Abstract Transparent glass-ceramics based on iron-doped ZnAl2O4 (gahnite) nanocrystals were prepared by melt-quenching (at 1580 °C) with subsequent heat-treatments (at 720 – 1050 °C). Polycrystalline transparent Fe:ZnAl2O4 ceramic was synthesized by hot pressing of powders (at 1600 °C, 50 MPa) using the sintering additive, ZnF2. A comparative study of the structure, Raman spectra and absorption properties of these materials was performed.
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36

Sun, Dong Mei, Shu Fang Fu, Sheng Zhou, and Qiang Hua Li. "Nonlinear Infrared Transmission through and Reflection Off Antiferromagnetic Sandwich NM/AFF/NM." Solid State Phenomena 181-182 (November 2011): 360–63. http://dx.doi.org/10.4028/www.scientific.net/ssp.181-182.360.

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The reflectivity and transmission spectra will be discussed in an antiferromagnetic (AF) sandwich structure as ZnF2/MnF2/SiO2. Such geometry is used, where the AF anisotropy axis and external static magnetic field both are parallel to the film surfaces and normal to the incident plane. The results show that the reflectivity and transmission spectra can be governed by the incident angles and the AF thickness.
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37

Ravi Kumar, V., and N. Veeraiah. "Dielectric properties of ZnF2-PbO-TeO2 glasses." Journal of Physics and Chemistry of Solids 59, no. 1 (January 1998): 91–97. http://dx.doi.org/10.1016/s0022-3697(97)00145-5.

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38

Yamazaki, Hiroki, and Junko Satooka. "Magnetic phase transition of FeF2/ZnF2 superlattices." Journal of Magnetism and Magnetic Materials 240, no. 1-3 (February 2002): 442–44. http://dx.doi.org/10.1016/s0304-8853(01)00893-9.

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39

Alcalá, R., R. Cases, P. J. Alonso, and V. M. Orera. "Radiation effects in ZnF2CdF2 based glasses." Materials Research Bulletin 26, no. 10 (October 1991): 1019–25. http://dx.doi.org/10.1016/0025-5408(91)90084-y.

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40

Watanabe, Susan M., Madeleine Strickland, Nico Tjandra, and Carol A. Carter. "RNA Binding Suppresses Tsg101 Recognition of Ub-Modified Gag and Facilitates Recruitment to the Plasma Membrane." Viruses 12, no. 4 (April 15, 2020): 447. http://dx.doi.org/10.3390/v12040447.

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The ESCRT-I factor Tsg101 is essential for sorting endocytic cargo and is exploited by viral pathogens to facilitate egress from cells. Both the nucleocapsid (NC) domain and p6 domain in HIV-1 Gag contribute to recruitment of the protein. However, the role of NC is unclear when the P(S/T)AP motif in p6 is intact, as the motif recruits Tsg101 directly. The zinc fingers in NC bind RNA and membrane and are critical for budding. Tsg101 can substitute for the distal ZnF (ZnF2) and rescue budding of a mutant made defective by deletion of this element. Here, we report that the ubiquitin (Ub) E2 variant (UEV) domain in Tsg101 binds tRNA in vitro. We confirmed that Tsg101 can substitute for ZnF2 when provided at the viral assembly site as a chimeric Gag-Tsg101 protein (Gag-ΔZnF2-Tsg101) and rescue budding. The UEV was not required in this context; however, mutation of the RNA binding determinants in UEV prevented Tsg101 recruitment from the cell interior when Gag and Tsg101 were co-expressed. The same Tsg101 mutations increased recognition of Gag-Ub, suggesting that tRNA and Ub compete for binding sites. This study identifies a novel Tsg101 binding partner that may contribute to its function in recognition of Ub-modified cargo.
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41

Zahirieh, Alireza, M. Andrew Nesbit, Asif Ali, Kairong Wang, Ning He, Maria Stangou, Gerasimos Bamichas, Kostas Sombolos, Rajesh V. Thakker, and York Pei. "Functional Analysis of a Novel GATA3 Mutation in a Family with the Hypoparathyroidism, Deafness, and Renal Dysplasia Syndrome." Journal of Clinical Endocrinology & Metabolism 90, no. 4 (April 1, 2005): 2445–50. http://dx.doi.org/10.1210/jc.2004-1969.

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Abstract The hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is an autosomal dominant disorder caused by mutations of a member of the GATA-binding family of transcription factors, GATA3. This dual zinc finger transcription factor binds DNA with its C-terminal zinc finger (ZnF2) and stabilizes this binding with its N-terminal zinc finger (ZnF1). ZnF1 also interacts with other zinc finger proteins, notably Friend of GATA (FOG). The HDR syndrome has been described in patients with mutations affecting both ZnF1 and ZnF2 domains; the former result in inefficient interaction with FOG, and the latter result in disruption of DNA binding. We report a patient with renal failure, hypoparathyroidism, and bilateral hearing loss. Assessment of family members indicated that the disease arose as a de novo mutation in her mother. Analysis of GATA3 in the family revealed a heterozygous missense mutation resulting in a nonconservative change of a single amino acid (R276P) in the ZnF1 domain. Functional analysis using dissociation electrophoretic mobility shift and yeast two-hybrid assays showed reduced binding affinity to the GATA motifs but normal interaction with FOG in vitro. These results are consistent with the predicted functions of human GATA3-ZnF1 from three-dimensional molecular modeling and with HDR being a result of GATA3 haploinsufficiency.
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42

Rahimi-Nasrabadi, Mehdi, Mohsen Behpour, Ali Sobhani-Nasab, and S. Mostafa Hosseinpour-Mashkani. "ZnFe2−xLaxO4 nanostructure: synthesis, characterization, and its magnetic properties." Journal of Materials Science: Materials in Electronics 26, no. 12 (August 20, 2015): 9776–81. http://dx.doi.org/10.1007/s10854-015-3648-1.

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43

Zhang, Quanli, Xiufen Zheng, Qi Sun, Run Shi, Jie Wang, Biqing Zhu, Lin Xu, Guangqin Zhang, and Binhui Ren. "ZNF692 promotes proliferation and cell mobility in lung adenocarcinoma." Biochemical and Biophysical Research Communications 490, no. 4 (September 2017): 1189–96. http://dx.doi.org/10.1016/j.bbrc.2017.06.180.

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44

Niu, Pingping, Weihao Zhao, Guofang Jiang, and Cancheng Guo. "A Novel ZnF2-Catalyzed Esterification of Oleic Acid." Asian Journal of Chemistry 26, no. 22 (2014): 7776–78. http://dx.doi.org/10.14233/ajchem.2014.17797.

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45

Ravi Kumar, V., N. Veeraiah, S. Buddhudu, and V. Jaya Tyaga Raju. "Dielectric Dispersion in CuO Doped ZnF2–PbO–TeO2 Glasses." Journal de Physique III 7, no. 5 (May 1997): 951–61. http://dx.doi.org/10.1051/jp3:1997167.

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46

Wang, Lei, Peng-Fei Yuan, Fei Wang, Qiang Sun, Er-Jun Liang, and Yu Jia. "Theoretical study of negative thermal expansion mechanism of ZnF2." Materials Research Bulletin 47, no. 5 (May 2012): 1113–18. http://dx.doi.org/10.1016/j.materresbull.2012.02.020.

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47

Miura, Noboru, Takashi Sasaki, Hironaga Matsumoto, and Ryotaro Nakano. "Strong Ultraviolet-Emitting ZnF2:Gd Thin Film Electroluminescent Device." Japanese Journal of Applied Physics 30, Part 2, No. 10B (October 15, 1991): L1815—L1816. http://dx.doi.org/10.1143/jjap.30.l1815.

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48

Yamashita, Nobuhiko, Takeshi Sumi, Kaizo Nakamura, and Sumitada Asano. "Photoluminescence Properties of ZnF2:Mn2+, (Zn, Mn)F2and MnF2." Journal of the Physical Society of Japan 60, no. 3 (March 15, 1991): 1105–14. http://dx.doi.org/10.1143/jpsj.60.1105.

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49

Neeraja, K., A. Rupesh Kumar, T. G. V. M. Rao, P. Vijayalakshmi, and M. Rami Reddy. "The Spectroscopic Properties of Mo5+in ZnO-ZnF2-B2O3Glasses." Transactions of the Indian Ceramic Society 72, no. 1 (March 2013): 24–28. http://dx.doi.org/10.1080/0371750x.2013.794001.

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50

Yin, Huiqin, Shuang Wu, Xueliang Wang, Long Yan, Wenguan Liu, and Zhongfeng Tang. "Thermodynamic description for the NaF-KF-RbF-ZnF2 system." Journal of Fluorine Chemistry 217 (January 2019): 90–96. http://dx.doi.org/10.1016/j.jfluchem.2018.09.008.

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