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Journal articles on the topic 'Zn-curcumin'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Hieu, Tran Quang, and Doan Thi Thanh Thao. "Enhancing the Solubility of Curcumin Metal Complexes and Investigating Some of Their Biological Activities." Journal of Chemistry 2019 (September 2, 2019): 1–8. http://dx.doi.org/10.1155/2019/8082195.

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This article describes the synthesis of curcumin complexes with metal ions. Properties of these complexes such as spectra IR and UV-Vis and solubility were investigated. The optimum parameters of ultrasound to enhance the solubility was figured out as follows: the capacity of ultrasound: 750 W/g; the time of ultrasound: 7 min; the concentration of the surfactant Tween 80 : 2%. The maximum solubility (mg/ml) of complexes was as follows: Cur-Fe(III): 0.162 ± 0.01; Cur-Zn(II): 0.267 ± 0.02; and Cur-Ca(II): 0.417 ± 0.05. Antioxidant capacity (DPPH, %I) of curcumin complexes was higher than that of curcumin-free complexes. All of these curcumin complexes revealed antimicrobial activities, in which calcium complex had the best resistance against Salmonella, followed by Fe(III) complexes. Meanwhile, the zinc complex was not resistant to this bacterium. These complexes showed antibacterial activity on Staphylococcus aureus, in which Cur-Ca (II) complexes had the highest antibacterial activity. For Escherichia coli, the Cur-Zn (II) complex had no resistance, while the Cur-Ca (II) complex showed the highest antibacterial activity.

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2

Wang, Zhen-Feng, Qun-Xue Nong, Hua-Lian Yu, Qi-Pin Qin, Feng-Hua Pan, Ming-Xiong Tan, Hong Liang, and Shu-Hua Zhang. "Complexes of Zn(ii) with a mixed tryptanthrin derivative and curcumin chelating ligands as new promising anticancer agents." Dalton Transactions 51, no. 13 (2022): 5024–33. http://dx.doi.org/10.1039/d1dt04095b.

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3

Wu, Rihui, Xueting Mei, Jiasheng Wang, Wenjia Sun, Ting Xue, Caixia Lin, and Donghui Xu. "Zn(ii)-Curcumin supplementation alleviates gut dysbiosis and zinc dyshomeostasis during doxorubicin-induced cardiotoxicity in rats." Food & Function 10, no. 9 (2019): 5587–604. http://dx.doi.org/10.1039/c9fo01034c.

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4

Pranata, Alvin, and Reggie Surya. "Effects of The Addition of Complexing Agents on Curcumin Stability Using Accelerated Shelf Life Testing." Journal of Physics: Conference Series 2049, no. 1 (October 1, 2021): 012034. http://dx.doi.org/10.1088/1742-6596/2049/1/012034.

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Abstract Curcumin as a natural colorant product from turmeric used in food industry has low stability. Curcumin is easily oxidized due to light, oxygen, or high temperature. One of the methods that can be used to increase its stability is by complexation process using metal ions. The aim of this research are to determine product shelf life and the best complexing agent to increase curcumin stability. In this research there were three complexing agent used to form curcumin complex. Then, the stability of products are measured through curcumin concentration parameter and based on its shelf life using Accelerated Shelf Life Testing (ASLT) method. The results stated that curcumin-Zn complex exerted the highest stability against control and other complexing agent, hence the shelf life was projected to increase by 10-15 days at 35°C compared to untreated liquid curcumin. Conversely curcumin-Fe complex demonstrated the lowest shelf life due to the role of Fe as a potential oxidizing agent.

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5

Su, Hongmin, Fuxing Sun, Jiangtao Jia, Hongming He, Aifei Wang, and Guangshan Zhu. "A highly porous medical metal–organic framework constructed from bioactive curcumin." Chemical Communications 51, no. 26 (2015): 5774–77. http://dx.doi.org/10.1039/c4cc10159f.

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6

Banerjee, Rona. "Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation." Bioinorganic Chemistry and Applications 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/325873.

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Mononuclear complexes of Curcumin with Cu(II) and Zn(II) have been synthesized and, characterized and their effects on the fibrillization and aggregation of amyloid-beta (Aβ) peptide have been studied. FTIR spectroscopy and atomic force microscopy (AFM) observations demonstrate that the complexes can inhibit the transition from less structured oligomers toβ-sheet rich protofibrils which act as seeding factors for further fibrillization. The metal complexes also impart more improved inhibitory effects than Curcumin on peptide fibrillization.

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Du, Yu, Xiaojian Li, Xiang Ren, Huan Wang, Dan Wu, Hongmin Ma, Dawei Fan, and Qin Wei. "Signal-off electrochemiluminescence immunosensors based on the quenching effect between curcumin-conjugated Au nanoparticles encapsulated in ZIF-8 and CdS-decorated TiO2 nanobelts for insulin detection." Analyst 145, no. 5 (2020): 1858–64. http://dx.doi.org/10.1039/c9an02288k.

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8

Pucci, Daniela, Alessandra Crispini, Bárbara Sanz Mendiguchía, Sante Pirillo, Mauro Ghedini, Sabrina Morelli, and Loredana De Bartolo. "Improving the bioactivity of Zn(ii)-curcumin based complexes." Dalton Transactions 42, no. 26 (2013): 9679. http://dx.doi.org/10.1039/c3dt50513h.

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9

Shahcheraghi, Seyed Hossein, Fateme Salemi, Niloufar Peirovi, Jamshid Ayatollahi, Waqas Alam, Haroon Khan, and Luciano Saso. "Nrf2 Regulation by Curcumin: Molecular Aspects for Therapeutic Prospects." Molecules 27, no. 1 (December 28, 2021): 167. http://dx.doi.org/10.3390/molecules27010167.

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Nuclear factor erythroid 2 p45-related factor (2Nrf2) is an essential leucine zipper protein (bZIP) that is primarily located in the cytoplasm under physiological conditions. Nrf2 principally modulates endogenous defense in response to oxidative stress in the brain.In this regard, Nrf2 translocates into the nucleus and heterodimerizes with the tiny Maf or Jun proteins. It then attaches to certain DNA locations in the nucleus, such as electrophile response elements (EpRE) or antioxidant response elements (ARE), to start the transcription of cytoprotective genes. Many neoplasms have been shown to have over activated Nrf2, strongly suggesting that it is responsible for tumors with a poor prognosis. Exactly like curcumin, Zinc–curcumin Zn (II)–curc compound has been shown to induce Nrf2 activation. In the cancer cell lines analyzed, Zinc–curcumin Zn (II)–curc compound can also display anticancer effects via diverse molecular mechanisms, including markedly increasing heme oxygenase-1 (HO-1) p62/SQSTM1 and the Nrf2 protein levels along with its targets. It also strikingly decreases the levels of Nrf2 inhibitor, Kelch-like ECH-associated protein 1 (Keap1) protein.As a result, the crosstalk between p62/SQSTM1 and Nrf2 could be used to improve cancer patient response to treatments. The interconnected anti-inflammatory and antioxidative properties of curcumin resulted from its modulatory effects on Nrf2 signaling pathway have been shown to improve insulin resistance. Curcumin exerts its anti-inflammatory impact through suppressing metabolic reactions and proteins such as Keap1 that provoke inflammation and oxidation. A rational amount of curcumin-activated antioxidant Nrf2 HO-1 and Nrf2-Keap1 pathways and upregulated the modifier subunit of glutamate-cysteine ligase involved in the production of the intracellular antioxidant glutathione. Enhanced expression of glutamate-cysteine ligase, a modifier subunit (GLCM), inhibited transcription of glutamate-cysteine ligase, a catalytic subunit (GCLC). A variety of in vivo, in vitro and clinical studies has been done so far to confirm the protective role of curcumin via Nrf2 regulation. This manuscript is designed to provide a comprehensive review on the molecular aspects of curcumin and its derivatives/analogs via regulation of Nrf2 regulation.

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10

Hasan, Akhmad Endang Zainal, Mega Safithri, Aziz Syamsul Huda, and Rini Kurniasih. "IN SILICO, TO DETERMINE THE ACTIVE COMPOUNDS OF BLACK TEA AND TURMERIC IN INCREASING THE ACTIVITY OF THE ENZYME SOD." Indonesian Journal of Applied Research (IJAR) 3, no. 1 (May 12, 2022): 32–45. http://dx.doi.org/10.30997/ijar.v3i1.187.

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Damage to cells caused by stress can be reduced by the presence of antioxidants, one of which is Superoxide dismutase (SOD). The role of the active ingredients of black tea and turmeric will be studied using the in-silico method to identify the active compounds as components in SOD activation. The bioavailability and toxicity of the active compounds of black tea and turmeric were studied and followed by molecular docking and virtual games. The parameters studied are Gibbs's free energy (∆G) and binding site similarity (BSS). The results were analyzed using Gibbs's free energy (∆G) and binding site similarity (BSS) parameters. It was found that those that could increase the activity of Cu/Zn SOD enzymes were Epicatechin gallate (black tea) and curcumin (turmeric), with values of -9.5 and -7.4 Kcal/mol and the same BSS value of 81.8%. The control ligand used was beta amyrin. According to Lipinski's rules, Epicatechin gallate and curcumin compounds can be absorbed well and are safe for consumption. This study concludes that Epicatechin gallate, an active compound of black tea, and curcumin, an active compound of turmeric rhizome, have the best potential to increase the activity of Cu/Zn SOD enzymes based on the results of virtual screening and molecular docking. Epicatechin gallate and curcumin are predicted to be well absorbed by the body because they qualify Lipinski's rules and are not toxic and safe for consumption.

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Garufi, Alessia, Eugenia Giorno, Maria Saveria Gilardini Montani, Giuseppa Pistritto, Alessandra Crispini, Mara Cirone, and Gabriella D’Orazi. "p62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)–Curcumin Complex." Biomolecules 11, no. 3 (February 25, 2021): 348. http://dx.doi.org/10.3390/biom11030348.

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The hyperactivation of nuclear factor erythroid 2 p45-related factor 2 (NRF2), frequently found in many tumor types, can be responsible for cancer resistance to therapies and poor patient prognosis. Curcumin has been shown to activate NRF2 that has cytotprotective or protumorigenic roles according to tumor stage. The present study aimed at investigating whether the zinc–curcumin Zn(II)–curc compound, which we previously showed to display anticancer effects through multiple mechanisms, could induce NRF2 activation and to explore the underlying molecular mechanisms. Biochemical studies showed that Zn(II)–curc treatment increased the NRF2 protein levels along with its targets, heme oxygenase-1 (HO-1) and p62/SQSTM1, while markedly reduced the levels of Keap1 (Kelch-like ECH-associated protein 1), the NRF2 inhibitor, in the cancer cell lines analyzed. The silencing of either NRF2 or p62/SQSTM1 with specific siRNA demonstrated the crosstalk between the two molecules and that the knockdown of either molecule increased the cancer cell sensitivity to Zn(II)–curc-induced cell death. This suggests that the crosstalk between p62/SQSTM1 and NRF2 could be therapeutically exploited to increase cancer patient response to therapies.

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12

Salh, Hala M., and Taghreed H. Al-Noor. "Preparation, Structural Characterization and Biological Activities of Curcumin-Metal(II)-L-3,4-dihydroxyphenylalanin (L-dopa) complexes." Ibn AL-Haitham Journal For Pure and Applied Sciences 36, no. 1 (January 20, 2023): 170–85. http://dx.doi.org/10.30526/36.1.2899.

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In the present work, a first-row divalent d-transition metal obtained from curcumin(Curc) and L-3,4-dihydroxyphenylalanin(L-dopa)have been synthesized which their complexes and characterized by C.H.N, conductance, spectral methods: FT-IR, Ultra–Visible. Magneto-chemical measurements, molar conductance ΛM (1×10−3 mol/L in DMSO):36- 0.84 ohm-1.cm2.mol-1 (non-electrolyte). The data shows that the complexes have the structure [M((II))-(Curc)-(L-dopa)] system. Electronic and magnetic data suggest an octahedral geometry for all complexes in which the (L-dopa) and curcumin act as bidentate ligands. Curcumin coordinated to the metal ions M (II) through the lone pair of electrons of oxygen in 2(C=O) groups. The (L-dopa) coordinated to M (II) as a mono negative bidentate ligand through the oxygen atom of the carboxylate and the (N), atom of the (-NH2) groups. The general formula was given for the prepared mixed ligand complexes as [M (Cur)(L-dopa)2 ]. M= Mn (II), Fe (II),Co(II),Ni(II),Cu (II), Zn(II), Cd(II) and Hg(II).The ligands and their metal complexes were screened for their antimicrobial activity klebsiella pneumonie,and Staphylococcus aureus, and Candida albicans. Metal chelates showed very good antimicrobial activity than their parent curcumin-and (L- dopa). We have given the general formula for the prepared mixed ligand complexes as [M (Cur)(L-dopa)2].M= Mn (II), Fe (II),Co(II) ,Ni(II),Cu (II), Zn(II), Cd(II) and Hg(II).The ligands and their metal complexes were screened for their antimicrobial activity klebsiella pneumonie,and Staphylococcus aureus, and Candida albicans. Metal chelates show very good antimicrobial activity than their parent Curcumin-and (L- dopa).

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Singh, Chandra K., Gagan Chhabra, Arth Patel, Hao Chang, and Nihal Ahmad. "Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management." Nutrients 13, no. 6 (May 30, 2021): 1867. http://dx.doi.org/10.3390/nu13061867.

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Studies have suggested an important role of the trace element zinc (Zn) in prostate biology and functions. Zn has been shown to exist in very high concentrations in the healthy prostate and is important for several prostatic functions. In prostate cancer (PCa), Zn levels are significantly decreased and inversely correlated with disease progression. Ideally, restoration of adequate Zn levels in premalignant/malignant prostate cells could abort prostate malignancy. However, studies have shown that Zn supplementation is not an efficient way to significantly increase Zn concentrations in PCa. Based on a limited number of investigations, the reason for the lower levels of Zn in PCa is believed to be the dysregulation of Zn transporters (especially ZIP and ZnT family of proteins), metallothioneins (for storing and releasing Zn), and their regulators (e.g., Zn finger transcription factor RREB1). Interestingly, the level of Zn in cells has been shown to be modulated by naturally occurring dietary phytochemicals. In this review, we discussed the effect of selected phytochemicals (quercetin, resveratrol, epigallocatechin-3-gallate and curcumin) on Zn functioning and proposes that Zn in combination with specific dietary phytochemicals may lead to enhanced Zn bioaccumulation in the prostate, and therefore, may inhibit PCa.

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14

Grabner and Modec. "Zn(II) Curcuminate Complexes with 2,2’-bipyridine and Carboxylates." Molecules 24, no. 14 (July 11, 2019): 2540. http://dx.doi.org/10.3390/molecules24142540.

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Two novel zinc(II) compounds with curcuminate (abbreviated as cur–), [Zn(CH3COO)(cur)(bpy)](1)·CH3OH·2H2O (bpy = 2,2’-bipyridine) and [Zn(PhCOO)(cur)(bpy)] (2)·CH3OH, have been synthesized and characterized. Their composition has been determined by single-crystal X-ray structure analysis. Complexes 1 and 2 are similar: in both a five-fold coordination environment of zinc(II) consists of a monodentate carboxylate, a chelating bidentate 2,2’-bipyridine, and curcuminate, which is bound via a deprotonated 1,3-dione moiety. In 1, 2,2’-bipyridine nitrogen atoms and curcuminate oxygen atoms form the base of a square pyramid, whereas the acetate oxygen occupies its apex. The O3N2 donor set in 2 defines a polyhedron which more closely resembles a trigonal bipyramid. The packing in the crystal lattices of both compounds is governed by hydrogen-bonds. Complexes 1 and 2 display higher stability than curcumin in buffered media at pH = 7.0, however, the degradation of coordinated cur– is comparable to that of yellow pigment curcumin (curH) when the pH is raised to 7.2. Both complexes 1 and 2 in DMSO exhibit fluorescence with Stokes shifts of 5367 and 4634 cm−1, respectively.

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15

Cai, Mengru, Liuying Qin, Linnuo Pang, Baorui Ma, Jie Bai, Jing Liu, Xiaoxv Dong, Xingbin Yin, and Jian Ni. "Amino-functionalized Zn metal organic frameworks as antitumor drug curcumin carriers." New Journal of Chemistry 44, no. 41 (2020): 17693–704. http://dx.doi.org/10.1039/d0nj03680c.

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16

Pucci, Daniela, Tommaso Bellini, Alessandra Crispini, Igea D'Agnano, Paola F. Liguori, Pilar Garcia-Orduña, Sante Pirillo, Alessandra Valentini, and Giuliano Zanchetta. "DNA binding and cytotoxicity of fluorescent curcumin-based Zn(ii) complexes." MedChemComm 3, no. 4 (2012): 462. http://dx.doi.org/10.1039/c2md00261b.

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17

Qin, Li-Qin, Chun-Jie Liang, Zhen Zhou, Qi-Pin Qin, Zu-Zhuang Wei, Ming-Xiong Tan, and Hong Liang. "Mitochondria-localizing curcumin-cryptolepine Zn(II) complexes and their antitumor activity." Bioorganic & Medicinal Chemistry 30 (January 2021): 115948. http://dx.doi.org/10.1016/j.bmc.2020.115948.

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18

Tanrıkulu-Küçük, Sevda, Canan Başaran-Küçükgergin, Muhammed Seyithanoğlu, Semra Doğru-Abbasoğlu, Hikmet Koçak, Şule Beyhan-Özdaş, and Yıldız Öner-İyidoğan. "Effect of dietary curcumin and capsaicin on testicular and hepatic oxidant–antioxidant status in rats fed a high-fat diet." Applied Physiology, Nutrition, and Metabolism 44, no. 7 (July 2019): 774–82. http://dx.doi.org/10.1139/apnm-2018-0622.

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This study investigated the effects of curcumin and capsaicin on testicular and hepatic oxidant–antioxidant status in rats fed a high-fat diet (HFD). Male Sprague–Dawley rats were divided into 5 groups (8 rats per group). The control group was fed a normal control diet (standard laboratory chow), the HFD group was fed HFD (60% of total calories from fat), the HFD+CUR group received HFD supplemented with curcumin (1.5 g curcumin/kg HFD), the HFD+CAP group was given HFD supplemented with capsaicin (0.15 g capsaicin/kg HFD), and the HFD+CUR+CAP group received HFD supplemented with curcumin and capsaicin for 16 weeks. Hepatic and testicular thiobarbituric acid reactive substances (TBARS), reactive oxygen species (ROS), glutathione (GSH) levels, glutathione transferase activity, and Cu-Zn superoxide dismutase, glutathione peroxidase, and catalase protein expression and enzyme activities were measured. Protein expression was determined by Western blotting. GSH levels and antioxidant enzyme activities were measured with colorimetric methods. HFD slightly increased hepatic and testicular oxidative stress parameters. GSH levels did not change between groups. TBARS and ROS levels were significantly reduced in the HFD+CUR+CAP group compared with the HFD group. Liver and testis antioxidant enzyme activities and expression increased significantly with combined capsaicin and curcumin treatment. Curcumin and capsaicin treatment attenuated testicular and hepatic oxidative stress and enhanced the antioxidant defense system. The combination of capsaicin and curcumin with HFD seems to have some remarkable and beneficial effects on testicular oxidative damage in the fatty liver rat model.

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Sayyar, Zahra, and Hoda Jafarizadeh Malmiri. "Photocatalytic and antibacterial activities study of prepared self-cleaning nanostructure surfaces using synthesized and coated ZnO nanoparticles with Curcumin nanodispersion." Zeitschrift für Kristallographie - Crystalline Materials 234, no. 5 (May 27, 2019): 307–28. http://dx.doi.org/10.1515/zkri-2018-2096.

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Abstract Zinc oxide nanoparticles had been synthesized and encapsulated using Curcumin nanoemulsions, Zn(Cur)O NPs, under subcritical water conditions. The effects of temperature (120, 140 and 160 °C) and pH values of the reaction solution (4, 7 and 10) on the particle size, grain size, cristallinity, specific surface area, band gap, Urbach energy, morphology, photocatalytic activity and antibacterial properties of the prepared Zn(Cur)O NPs were evaluated using XRD, FT-IR, SEM, EDX and UV-Vis spectroscopy analysis. The obtained results indicate that the prepared spherical and rod shapes Zn(Cur)O NPs had a crystallite size distribution of 10–100 nm. Furthermore, the results reveal that most uniform Zn(Cur)O NPs with highest photocatalytic activity, quantum yield (0.161 mol·m−2 s−1), specific surface area (242 m2/g), minimum band gap (2.62 eV) and Urbach energy (0.125 meV) were formed at 160 °C and natural pH. The highest antibacterial activities against both Gram positive and negative bacteria strains, were achieved using the synthesized Zn(Cur)O at 160 °C and basic pH(10).

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20

Joice, M. Vimala, and P. Metilda Metilda. "Investigation of Metal(II)-Curcumin-Glycine Complexes : Preparation, Structural Characterization and Biological Activities." Oriental Journal Of Chemistry 37, no. 2 (April 30, 2021): 397–404. http://dx.doi.org/10.13005/ojc/370219.

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A novel Schiff base obtained from curcumin and glycine was prepared and it was reacted with Co, Ni, Cu and Zn metals in order to form the stable metal complexes and characterized by elemental analysis, magnetic, molar conductance, IR, UV-Vis.,1H NMR and PXRD. The data shows that the complexes have the structure [M(II)-(cur-gly)H2O] system Electronic and magnetic data suggest a tetrahedral geometry for Co, Ni and Zn except Cu complex has a square planar geometry. The antimicrobial activity of cur-gly and its metal chelates were confirmed against the bacterial species as E. coli, P. aeruginosa, Enterococcus, B. cereus and S. aureus species. Antifungal activity was screened against C. albicans, C. parapsilosis and A. flavus. Metal chelates indicate excellent antimicrobial activity than their parent cur-gly and DNA photo cleavage activity shows that metal chelate effectively cleave the pUC 18 DNA.

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Mohammad, Chenar Anwar. "Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL-1β, and TNF-α in Chronic Periodontitis Patients." BioMed Research International 2020 (October 5, 2020): 1–11. http://dx.doi.org/10.1155/2020/8850926.

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Curcumin exhibits antibacterial, antioxidant, and anti-inflammatory effects and has been suggested as a treatment for inflammatory diseases. The study is aimed at evaluating the effect of curcumin gel on serum levels of micronutrients (zinc, copper, and magnesium) and proinflammatory cytokines (IL-1β and TNF-α) in chronic periodontitis patients. Ninety subjects with an age of 25-54 were included in this study. From the total number, 30 subjects with healthy periodontium (control group) ( mean age = 37.30 ± 7.08 ) were employed for the sole purpose of obtaining the normal mean values of clinical, chemical, and immunological parameters, and 60 with chronic periodontitis ( mean age = 36.73 ± 6.22 ) were divided randomly into 2 groups, of which each group included 30 subjects. Group A received scaling and root planing SRP and curcumin gel injection covered by Coe pack for 7 days, and group B received SRP alone covered by Coe pack. Clinical parameters (plaque index, gingival index, bleeding on probing, pocket depth, and clinical attachment loss measurements) and blood samples were collected before and after 1 month of treatment to measure serum levels of zinc, copper, magnesium, IL-1β, and TNF-α. The results showed significant micronutrient alteration and increase of proinflammatory cytokines in the chronic periodontitis group as compared to healthy control ( P ≤ 0.05 ), and curcumin gel had a significant effect on the reduction of IL-1β, TNF-α, copper, and clinical parameters ( P ≤ 0.05 ) and increase of zinc and magnesium levels after 1 month as compared to baseline ( P ≤ 0.05 ), nearly the same pattern for group B but with nonsignificant differences for Zn ( P > 0.05 ). In conclusion, curcumin gel resulted in a more significant reduction in clinical parameters, inflammatory mediators, and copper and increase of zinc and magnesium levels as compared to SRP alone.

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Tone, C. M., S. Pirillo, D. Pucci, M. P. De Santo, R. C. Barberi, and F. Ciuchi. "AFM Studies on Curcumin Based Zn(II) Complex Molecules for Applications as Anticancer Agents." Molecular Crystals and Liquid Crystals 558, no. 1 (May 30, 2012): 194–203. http://dx.doi.org/10.1080/15421406.2011.654188.

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Ostrowski, Wojciech, Lidia Śniecikowska, Marcin Hoffmann, and Rafał Frański. "Demethoxycurcumin-Metal Complexes: Fragmentation and Comparison with Curcumin-Metal Complexes, as Studied by ESI-MS/MS." Journal of Spectroscopy 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/749641.

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Two questions are asked: the first is if the lack/presence of methoxyl moiety at aromatic ring essentially affects the stability of curcuminoid-metal complexes, and the second is if it is possible that in the metal complexes one of the possible demethoxycurcumin structures predominates. To answer the first question, the ESI-MS/MS spectra were taken of ions containing demethoxycurcumin, curcumin, and metal cation (e.g., ion [dCurc + Curc-H + Pb]+), and in order to answer the second question the ESI-MS/MS spectra were recorded of ions containing demethoxycurcumin and metal cation (e.g., ion [dCurc-H + Zn]+). An interpretation of the mass spectra has indicated that (i) for some metals, curcumin-metal complexes are more stable than demethoxycurcumin-metal complexes and for some metals vice versa, and (ii) in demethoxycurcumin-metal complexes structure B1 [(1E,4Z,6E)-5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)hepta-1,4,6-trien-3-one] is more stable than structure B2 [(1E,4Z,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,4,6-trien-3-one].

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SAIKHOM, Joylani D., Jekendra S. SALAM, Kumar S. POTSHANGBAM, Manabendra D. CHOUDHURY, and Haripriya D. MAIBAM. "Biochemical Studies in Some Indigenous Dye Yielding Plants of Manipur." Notulae Scientia Biologicae 5, no. 3 (August 1, 2013): 303–8. http://dx.doi.org/10.15835/nsb539078.

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Ten natural dye yielding and two mordant plants were biochemically analyzed. Though natural dyes are widely used, information about the active principles responsible for dyeing is hardly available. In the present experiment, total chlorophyll, carotinoids, tannins, phenolics, flavonoids and curcumin were determined among the dye yielding plants, while K, S, P, Ca, Mg, Mn, Zn, Fe, Cu and Co were determined in the case of mordant plants. In Bixa orellana, used for yellow dyeing, the carotinoid content was 163.11 mg g-1 and in Clerodendrum chinense and Datura stramonium, which were used for green colouring, total chlorophyll content of 10.29 mg and 11.83 mg g-1 was recorded. Curcumin content responsible for orange colouring in Curcuma domestica was 27.7 mg g-1 while flavonoid content in Solanum nigrum and Terminalia chebula, which were used for brown, brown to black dyes was 24.89 and 21.73 mg g-1. Among the plants used for dyeing different colours, Punica granatum and Parkia timoriana were found to contain higher amounts of total phenols and bound phenols by recording 681.2 mg g-1 and 287.6 mg g-1 total phenols and 151.6 mg g-1 and 130.2mg g-1 bound phenols, while higher amounts of orthodihydric phenols and tannins were recorded in Punica granatum and Strobilanthes flaccidifolius by recording 20.11mg g-1 and 9.54mg g-1 orthodihydric phenols and 675.57mg g-1 and 648.12 mg g-1 tannins, respectively. In case of the plants used as mordant, higher contents of Ca, Mg, K, Zn, Fe and Mn were detected in Achyranthes aspera, while higher amounts of P, Fe and Cu were recorded in Garcinia xanthochymus.

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Garufi, Alessia, Daniela Trisciuoglio, Manuela Porru, Carlo Leonetti, Antonella Stoppacciaro, Valerio D’Orazi, Maria Avantaggiati, Alessandra Crispini, Daniela Pucci, and Gabriella D’Orazi. "A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells." Journal of Experimental & Clinical Cancer Research 32, no. 1 (2013): 72. http://dx.doi.org/10.1186/1756-9966-32-72.

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Zhao, Xue-Zhou, Teng Jiang, Long Wang, Hao Yang, Sui Zhang, and Ping Zhou. "Interaction of curcumin with Zn(II) and Cu(II) ions based on experiment and theoretical calculation." Journal of Molecular Structure 984, no. 1-3 (December 2010): 316–25. http://dx.doi.org/10.1016/j.molstruc.2010.09.049.

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Dang, Y. Thi, Minh-Huy Dinh Dang, Ngoc Xuan Dat Mai, Linh Ho Thuy Nguyen, Thang Bach Phan, Hai Viet Le, and Tan Le Hoang Doan. "Room temperature synthesis of biocompatible nano Zn-MOF for the rapid and selective adsorption of curcumin." Journal of Science: Advanced Materials and Devices 5, no. 4 (December 2020): 560–65. http://dx.doi.org/10.1016/j.jsamd.2020.09.009.

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Pal, Sampa, Sanhita Maity, Subrata Sardar, Hasan Parvej, Niloy Das, Jishnu Chakraborty, and Umesh Chandra Halder. "Curcumin inhibits the Al(iii) and Zn(ii) induced amyloid fibrillation of β-lactoglobulin in vitro." RSC Advances 6, no. 112 (2016): 111299–307. http://dx.doi.org/10.1039/c6ra24570f.

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Pavel, Octavian D., Ariana Şerban, Rodica Zăvoianu, Elena Bacalum, and Ruxandra Bîrjega. "Curcumin Incorporation into Zn3Al Layered Double Hydroxides—Preparation, Characterization and Curcumin Release." Crystals 10, no. 4 (March 26, 2020): 244. http://dx.doi.org/10.3390/cryst10040244.

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Curcumin (CR) is a natural antioxidant compound extracted from Curcuma longa (turmeric). Until now, researches related to the incorporation of CR into layered double hydroxides (LDHs) were focused only on hybrid structures based on a MgxAl-LDH matrix. Our studies were extended towards the incorporation of CR in another type of LDH-matrix (Zn3Al-LDH) which could have an even more prolific effect on the antioxidant activity due to the presence of Zn. Four CR-modified Zn3Al-LDH solids were synthesized, e.g., PZn3Al-CR(Aq), PZn3Al-CR(Et), RZn3Al-CR(Aq) and RZn3Al-CR(Et) (molar ratio CR/Al = 1/10, where P and R stand for the preparation method (P = precipitation, R = reconstruction), while (Aq) and (Et) indicate the type of CR solution, aqueous or ethanolic, respectively). The samples were characterized by XRD, Attenuated Total Reflectance Fourier Transformed IR (ATR-FTIR) and diffuse reflectance (DR)-UV–Vis techniques and the CR-release was investigated in buffer solutions at different pH values (1, 2, 5, 7 and 8). XRD results indicated a layered structure for PZn3Al-CR(Aq), PZn3Al-CR(Et), RZn3Al-CR(Aq) impurified with ZnO, while RZn3Al-CR(Et) contained ZnO nano-particles as the main crystalline phase. For all samples, CR-release revealed a decreasing tendency towards the pH increase, and higher values were obtained for RZn3Al-CR(Et) and PZn3Al-CR(Et) (e.g., 45% and 25%, respectively at pH 1).

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Yan, Fa-Shun, Jian-Long Sun, Wen-Hai Xie, Liang Shen, and Hong-Fang Ji. "Neuroprotective Effects and Mechanisms of Curcumin–Cu(II) and –Zn(II) Complexes Systems and Their Pharmacological Implications." Nutrients 10, no. 1 (December 28, 2017): 28. http://dx.doi.org/10.3390/nu10010028.

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Sareen, Rashmi, Nitin Jain, and K. L. Dhar. "Curcumin–Zn(II) complex for enhanced solubility and stability: an approach for improved delivery and pharmacodynamic effects." Pharmaceutical Development and Technology 21, no. 5 (April 29, 2015): 630–35. http://dx.doi.org/10.3109/10837450.2015.1041042.

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Samayamanthula, Dhanu Radha, Badriyah Alhalaili, Harinath Yapati, Adnan Akber, and Chidambaram Sabarathinam. "Innovative Bacterial Removal Technique Using Green Synthetic Nano Curcumin Zinc (II) Complex for Sustainable Water Resource Management." Sustainability 14, no. 7 (April 4, 2022): 4289. http://dx.doi.org/10.3390/su14074289.

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Sustainable management of water resources is a daunting challenge, especially with respect to microbes. This study primarily focused on the development of a novel application for the removal of specific bacterial groups in different water types using a green synthetic nano Cur-Zn(II) complex. The results of UV and FT-IR spectroscopic techniques suggested the formation of a chelation complex. Proton NMR showed that the main enolic proton peak with a chemical shift of 16.45 nm identified in curcumin was missed, indicating the contribution of carbonyl oxygen of enol in the formation of the complex. The crystalline nature of the complex and Wurtzite structure of annealed products was inferred from the XRD analysis data. SEM results confirmed the complex’s morphology as spherical and clustered with a rough surface, having an average particle size of 68.2 nm. In addition, the complex was observed to be stable up to 300 °C without any decomposition from STA. Being acidic in nature with a pH of 5.36, the complex penetrates into the cell membrane and inhibit microbial growth. Intrinsically, no studies have been reported for the removal of microbes from water using natural materials embedded with inorganic metals, particularly in nano form. Therefore, the study is the first, innovative, eco-friendly, and economical method to use nano Cur-Zn(II) for removing targeted bacteria in real water samples with 100% efficiency by using optimized amounts (0.025–0.2 g/L) of the complex at a contact time interval between 4 and 24 h. The complex developed is toxic-free and can be applied in situ.

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Yu, Ying-Ying, Jin Niu, Peng Yin, Xue-Ting Mei, Yong-Jian Liu, Li-Xia Tian, and Dong-Hui Xu. "Detoxification and immunoprotection of Zn(II)-curcumin in juvenile Pacific white shrimp ( Litopenaeus vannamei ) feed with aflatoxin B1." Fish & Shellfish Immunology 80 (September 2018): 480–86. http://dx.doi.org/10.1016/j.fsi.2018.05.034.

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Qin, Qi-Pin, Zu-Zhuang Wei, Zhen-Feng Wang, Xiao-Ling Huang, Ming-Xiong Tan, Hua-Hong Zou, and Hong Liang. "Imaging and therapeutic applications of Zn(ii)-cryptolepine–curcumin molecular probes in cell apoptosis detection and photodynamic therapy." Chemical Communications 56, no. 28 (2020): 3999–4002. http://dx.doi.org/10.1039/d0cc00524j.

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Wu, Rihui, Xueting Mei, Yibiao Ye, Ting Xue, Jiasheng Wang, Wenjia Sun, Caixia Lin, Ruoxue Xue, Jiabao Zhang, and Donghui Xu. "Zn(II)-curcumin solid dispersion impairs hepatocellular carcinoma growth and enhances chemotherapy by modulating gut microbiota-mediated zinc homeostasis." Pharmacological Research 150 (December 2019): 104454. http://dx.doi.org/10.1016/j.phrs.2019.104454.

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Yu, Chuan, Xue-Ting Mei, Yan-Ping Zheng, and Dong-Hui Xu. "Zn(II)–curcumin protects against hemorheological alterations, oxidative stress and liver injury in a rat model of acute alcoholism." Environmental Toxicology and Pharmacology 37, no. 2 (March 2014): 729–37. http://dx.doi.org/10.1016/j.etap.2014.02.011.

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Jampilek, Josef, and Katarina Kralova. "Potential of Nanonutraceuticals in Increasing Immunity." Nanomaterials 10, no. 11 (November 9, 2020): 2224. http://dx.doi.org/10.3390/nano10112224.

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Nutraceuticals are defined as foods or their extracts that have a demonstrably positive effect on human health. According to the decision of the European Food Safety Authority, this positive effect, the so-called health claim, must be clearly demonstrated best by performed tests. Nutraceuticals include dietary supplements and functional foods. These special foods thus affect human health and can positively affect the immune system and strengthen it even in these turbulent times, when the human population is exposed to the COVID-19 pandemic. Many of these special foods are supplemented with nanoparticles of active substances or processed into nanoformulations. The benefits of nanoparticles in this case include enhanced bioavailability, controlled release, and increased stability. Lipid-based delivery systems and the encapsulation of nutraceuticals are mainly used for the enrichment of food products with these health-promoting compounds. This contribution summarizes the current state of the research and development of effective nanonutraceuticals influencing the body’s immune responses, such as vitamins (C, D, E, B12, folic acid), minerals (Zn, Fe, Se), antioxidants (carotenoids, coenzyme Q10, polyphenols, curcumin), omega-3 fatty acids, and probiotics.

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Xing, Zhou-Hao, Jin-Huan Wei, Tuck-Yun Cheang, Zong-Ren Wang, Xiao Zhou, Sha-Sha Wang, Wei Chen, Shen-Ming Wang, Jun-Hang Luo, and An-Wu Xu. "Bifunctional pH-sensitive Zn(ii)–curcumin nanoparticles/siRNA effectively inhibit growth of human bladder cancer cells in vitro and in vivo." Journal of Materials Chemistry B 2, no. 18 (2014): 2714. http://dx.doi.org/10.1039/c3tb21625j.

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39

Bhatia, Nidhi K., Ankit Srivastava, Nidhi Katyal, Nidhi Jain, M. Ashhar I. Khan, Bishwajit Kundu, and Shashank Deep. "Curcumin binds to the pre-fibrillar aggregates of Cu/Zn superoxide dismutase (SOD1) and alters its amyloidogenic pathway resulting in reduced cytotoxicity." Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1854, no. 5 (May 2015): 426–36. http://dx.doi.org/10.1016/j.bbapap.2015.01.014.

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Senthil Kumar, P. S., S. Aruna Geetha, P. Savithri, R. Jagadeeswaran, and K. P. Ragunath. "Effect of Zn enriched organic manures and zinc solubilizer application on the yield, curcumin content and nutrient status of soil under turmeric cultivation." Journal of Applied Horticulture 06, no. 02 (December 15, 2004): 82–86. http://dx.doi.org/10.37855/jah.2004.v06i02.18.

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41

Safarian, Hamide, Seyed Mahammad Reza Parizadeh, Maryam Saberi-Karimain, Susan Darroudi, Ali Javandoost, Farzaneh Mohammadi, Malihe Moammeri, Gordon A. Ferns, Majid Ghayour-Mobarhan, and Mohsen Mohebati. "The Effect of Curcumin on Serum Copper and Zinc and Zn/Cu Ratio in Individuals with Metabolic Syndrome: A Double-Blind Clinical Trial." Journal of Dietary Supplements 16, no. 6 (July 18, 2018): 625–34. http://dx.doi.org/10.1080/19390211.2018.1472711.

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42

Yu, Ying-ying, Shi-jun Chen, Ming Chen, Li-xia Tian, Jin Niu, Yong-jian Liu, and Dong-hui Xu. "Effect of cadmium-polluted diet on growth, salinity stress, hepatotoxicity of juvenile Pacific white shrimp (Litopenaeus vannamei): Protective effect of Zn(II)–curcumin." Ecotoxicology and Environmental Safety 125 (March 2016): 176–83. http://dx.doi.org/10.1016/j.ecoenv.2015.11.043.

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43

Mei, Xueting, Donghui Xu, Sika Xu, Yanping Zheng, and Shibo Xu. "Novel role of Zn(II)–curcumin in enhancing cell proliferation and adjusting proinflammatory cytokine-mediated oxidative damage of ethanol-induced acute gastric ulcers." Chemico-Biological Interactions 197, no. 1 (April 2012): 31–39. http://dx.doi.org/10.1016/j.cbi.2012.03.006.

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44

Meena, Bashdar I., Tara F. Tahir, Shalaw Z. Sdeeq, and Khalid N. Sediq. "Toxic Metals in Some Decorative Cosmetics and Nail Products." ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY 10, no. 2 (October 14, 2022): 56–61. http://dx.doi.org/10.14500/aro.11067.

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Cosmetic marketing is one of the most profitable and fast increasing markets in Kurdistan Region of Iraq. In recent years, the use of cosmetics has witnessed a rapid increase, especially with the emergence of social media and its impact on this trade. The market is full of different cosmetic brands and nail products. Moderate and low-quality brands of cosmetic samples that available in the local markets were selected to investigate their heavy metals and chemical composition. Samples from face foundation, eye shadow, and nail polish products were taken and examined to evaluate the concentration of metals, that is, Hg, Pb, Cd, As, Mn, Cr, Ni, Co, Fe, Zn, Cu, and Al ions, using X-ray diffraction and X-ray fluorescence techniques. The examination results show high concentrations of Fe and Al metals in the lipstick samples whereas the Hg, Cd, Cr, and Ni were out of detection limit. Moreover, the results show contamination of Hg heavy metal in one of the examined nail polishes brands, whereas the rest of foundation and eye shadow samples show a higher concentration of Al and Fe. Curcumin, as a natural bio-friendly chelate, has been used to deplete metal ions using ultraviolet-visible Spectrophotometer.

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45

Sorenson, John R. J., Lee S. F. Soderberg, Louis W. Chang, and Richard B. Walker. "Essential Metalloelement Chelates Facilitate Repair of Radiation Injury." Metal-Based Drugs 8, no. 4 (January 1, 2001): 215–34. http://dx.doi.org/10.1155/mbd.2001.215.

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Treatment with essential metalloelement (Cu, Fe, Mn, and Zn) chelates or combinations of them before and/or after radiation injury is a useful approach to overcoming radiation injury. No other agents are known to increase survival when they are used to treat after irradiation, in a radiorecovery treatment paradigm. These chelates may be useful in facilitating de novo syntheses of essential metalloelement-dependent enzymes required to repair radiation injury. Reports of radioprotection, which involves treatment before irradiation, with calcium-channel blockers, acyl Melatonin homologs, and substituted anilines, which may serve as chelating agents after biochemical modification in vivo, as well as Curcumin, which is a chelating agent, have been included in this review. These inclusions are intended to suggest additional approaches to combination treatments that may be useful in facilitating radiation recovery. These approaches to radioprotection and radiorecovery offer promise in facilitating recovery from radiation-induced injury experienced by patients undergoing radiotherapy for neoplastic disease and by individuals who experience environmental, occupational, or accidental exposure to ultraviolet, x-ray, or γ-ray radiation. Since there are no existing treatments of radiation-injury intended to facilitate tissue repair, studies of essential metalloelement chelates and combinations of them, as well as combinations of them with existing organic radioprotectants, seem worthwhile.

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Lu, Wen-Ping, Xue-Ting Mei, Yu Wang, Yan-Ping Zheng, Yun-Fei Xue, and Dong-Hui Xu. "Zn(II)–curcumin protects against oxidative stress, deleterious changes in sperm parameters and histological alterations in a male mouse model of cyclophosphamide-induced reproductive damage." Environmental Toxicology and Pharmacology 39, no. 2 (March 2015): 515–24. http://dx.doi.org/10.1016/j.etap.2014.12.014.

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Zhu, Xiangbing, Xijun Chang, Yuemei Cui, Xiaojun Zou, Dong Yang, and Zheng Hu. "Solid-phase extraction of trace Cu(II) Fe(III) and Zn(II) with silica gel modified with curcumin from biological and natural water samples by ICP-OES." Microchemical Journal 86, no. 2 (August 2007): 189–94. http://dx.doi.org/10.1016/j.microc.2007.03.002.

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48

Meza-Morales, William, M. Mirian Estévez-Carmona, Yair Alvarez-Ricardo, Marco A. Obregón-Mendoza, Julia Cassani, María Teresa Ramírez-Apan, Carolina Escobedo-Martínez, Manuel Soriano-García, William F. Reynolds, and Raúl G. Enríquez. "Full Structural Characterization of Homoleptic Complexes of Diacetylcurcumin with Mg, Zn, Cu, and Mn: Cisplatin-level Cytotoxicity in Vitro with Minimal Acute Toxicity in Vivo." Molecules 24, no. 8 (April 23, 2019): 1598. http://dx.doi.org/10.3390/molecules24081598.

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At the present time, scientists place a great deal of effort worldwide trying to improve the therapeutic potential of metal complexes of curcumin and curcuminoids. Herein, the synthesis of four homoleptic metal complexes with diacetylcurcumin (DAC), using a ligand designed to prevent the interaction of phenolic groups, rendering metal complexes through the β-diketone functionality, is reported. Due to their physiological relevance, we used bivalent magnesium, zinc, copper, and manganese for complexation with DAC. The resulting products were characterized by ultraviolet-visible (UV-Vis), fluorescence spectroscopy, infrared spectroscopy (IR), liquid and solid-state nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR), magnetic moment, mass spectrometry (MS), single crystal, and powder X-ray diffraction (SCXRD and PXRD). Crystallization was achieved in dimethylsulfoxide (DMSO) or N,N-dimethylformamide (DMF) as triclinic systems with space group P-1, showing the metal bound to the β-diketone function, while the 1H-NMR confirmed the preference of the enolic form of the ligand. Single crystal data demonstrated a 1:2 metal:ligand ratio. The inhibition of lipid peroxidation was evaluated using the thiobarbituric acid reactive substance assay (TBARS). All four metal complexes (Mg, Zn, Cu, and Mn) exhibited good antioxidant effect (IC50 = 2.03 ± 0.27, 1.58 ± 0.07, 1.58 ± 0.15 and 1.24 ± 0.10 μM respectively) compared with butylated hydroxytoluene (BHT) and α-tocopherol. The cytotoxic activity in human cancer cell lines against colon adenocarcinoma (HCT-15), mammary adenocarcinoma (MCF-7), and lung adenocarcinoma (SKLU-1) was found comparable ((DAC)2Mg), or ca. 2-fold higher ((DAC)2Zn) than cisplatin. The acute toxicity assays indicate class 5 toxicity, according to the Organization for Economic Co-operation and Development (OECD) guidelines at doses of 3 g/kg for all complexes. No mortality or changes in the behavior of animals in any of the treated groups was observed. A therapeutic potential can be envisaged from the relevant cytotoxic activity upon human cancer cell lines in vitro and the undetected in vivo acute toxicity of these compounds.

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R, Mahmoud, Safwat N, Fathy M, Mohamed N, El-Dek S, El-Banna H, Farghali A, and El-Ela FIA. "Novel Anti-Inflammatory and Wound Healing Controlled Released LDH-Curcumin Nanocomposite Via Intramuscular Implantation, In-Vivo Study." Austin Journal of Pharmacology and Therapeutics 9, no. 4 (July 8, 2021). http://dx.doi.org/10.26420/austinjpharmacolther.2021.1145.

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One of the most common problems in wounds is delayed healing and complications such as infection. Therefore, the need for novel materials accelerates the healing of wounds especially abdominal wounds after surgery besides high efficiency and safety is mandatory. The rate of wound healing, anti-inflammatory and biocompatibility of Zn-Al LDH alone and loaded with Curcumin was screened via in-vivo assays through intramuscular implantation in rat abdominal wall with intact peritoneum cavity. The implanted drugs were formed through Curcumin loaded into LDH of Zn-Al with drug release of 56.78 ±1.51% within 24 h. The synthesized nanocomposite was characterized by thermal analysis, X-ray diffraction, Field emission scanning microscopy, high resolution transmission electron microscope and BET surface area. The integrity of blood circulation, inflammatory signs, wound healing rate, capacity of tissue integration, antigenicity and composite biocompatibility, auto fluorescence ability of collagen bundles and the tensile strength of the muscle were assessed histopathologically after 7 and 30 days post-implantation. Excellent wound healing ability was achieved with shortest length between the wound gap edges and higher tensile strength of the muscle. Besides emit florescence very well followed by good healing and tensile muscles strength in Curcumin while very low strength with scar formation in Curcumin-Zn/Al-LDH in both acute and chronic wound. No signs of inflammation in Curcumin & Zn-Al LDH. No vessels obstruction or bleeding observed in both Zn/Al-LDH and Curcumin more than nanocurcumin and control which examined through candling. Good healing & infiltrated immune cells in same groups through histopathological examination. This work supports the anti-inflammatory, wound healing and biocompatibility of both LDH and Curcumin with living matter, increasing their biomedical applications in this era with safety and increasing efficacy with prolonged drug release.

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Aida, Atiqah. "SINTESA MATERIAL BIOSCAFFOLD BERBAHAN DASAR PLA/NANOKITOSAN DENGAN PENAMBAHAN ZN-CURCUMIN." Jurnal Sains dan Teknologi Reaksi 18, no. 02 (June 8, 2021). http://dx.doi.org/10.30811/jstr.v18i02.2255.

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Penelitian mengenai bioscaffold sebagai salah satu terobosan baru dalam bidang rekayasa jaringan sedang berkembang pesat untuk diteliti. Salah satu aplikasi bioscaffold dibidang rekayasa perancah jaringan tulang dapat memberikan solusi cepat untuk mendorong regenerasi jaringan tulang baru akibat kecelakaan kerja tulang serta cacat tulang. Material penyusun bioscaffold berupa sintesis maupun polimer alami. Polimer alami yang dapat digunakan ialah Poly Lactid Acid dikarenakan memiliki sifat yang sesuai dengan kriteria bioscaffold yakni biogradable, biokompatibel, tidak beracun dan aman bagi tubuh manusia. Namun sifat titik leleh PLA yang rendah dibandingkan polimer lainnya mengharuskan PLA dimodifikasi dengan bahan pengisi seperti Nanokitosan. Penggunaan Kitosan sebagai material bioscaffold telah dilakukan oleh Zuhra, 2017. Hasil yang didapatkan bahwa campuran dari kedua bahan tersebut bioscaffold yang kurang homogen berpengaruh terhadap kekuatan tarik bioscaffold. Adapun novelty dari penelitian ini adalah meninjau karakteristik material bioscaffold berbahan dasar PLA/ Nanokitosan dengan penambahan Zn-Curcumin . Penambahan Zn-Curcumin memiliki potensi nanofiber komposit sebagai perancah jaringan tulang melalui seluler morfologi dan MTT pengujian menunjukkan bahwa Zn-Cur yang mengandung nanofiber lebih baik mensupport adesi seluler, penyebaran dan proliferasi dibandingkan dengan nanofiber lainnya. Terlebih lagi ternyata penambahan Zn-Cur dapat meningkatkan aktivitas ALP dan produksi mineralisasi matriks Zn-CUR kompleks tidak hanya meningkatkan kinerja osteogenik tetapi juga memiliki aktivitas antibakteri yang baikKata kunci: Bioscaffold, PLA, Nanokitosan, Zn-Curcumin

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