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Relevant bibliographies by topics / Zn-curcumin

Academic literature on the topic 'Zn-curcumin'

Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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Journal articles

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Journal articles on the topic "Zn-curcumin"

1

Hieu, Tran Quang, and Doan Thi Thanh Thao. "Enhancing the Solubility of Curcumin Metal Complexes and Investigating Some of Their Biological Activities." Journal of Chemistry 2019 (September 2, 2019): 1–8. http://dx.doi.org/10.1155/2019/8082195.

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This article describes the synthesis of curcumin complexes with metal ions. Properties of these complexes such as spectra IR and UV-Vis and solubility were investigated. The optimum parameters of ultrasound to enhance the solubility was figured out as follows: the capacity of ultrasound: 750 W/g; the time of ultrasound: 7 min; the concentration of the surfactant Tween 80 : 2%. The maximum solubility (mg/ml) of complexes was as follows: Cur-Fe(III): 0.162 ± 0.01; Cur-Zn(II): 0.267 ± 0.02; and Cur-Ca(II): 0.417 ± 0.05. Antioxidant capacity (DPPH, %I) of curcumin complexes was higher than that of curcumin-free complexes. All of these curcumin complexes revealed antimicrobial activities, in which calcium complex had the best resistance against Salmonella, followed by Fe(III) complexes. Meanwhile, the zinc complex was not resistant to this bacterium. These complexes showed antibacterial activity on Staphylococcus aureus, in which Cur-Ca (II) complexes had the highest antibacterial activity. For Escherichia coli, the Cur-Zn (II) complex had no resistance, while the Cur-Ca (II) complex showed the highest antibacterial activity.

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2

Wang, Zhen-Feng, Qun-Xue Nong, Hua-Lian Yu, Qi-Pin Qin, Feng-Hua Pan, Ming-Xiong Tan, Hong Liang, and Shu-Hua Zhang. "Complexes of Zn(ii) with a mixed tryptanthrin derivative and curcumin chelating ligands as new promising anticancer agents." Dalton Transactions 51, no. 13 (2022): 5024–33. http://dx.doi.org/10.1039/d1dt04095b.

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3

Wu, Rihui, Xueting Mei, Jiasheng Wang, Wenjia Sun, Ting Xue, Caixia Lin, and Donghui Xu. "Zn(ii)-Curcumin supplementation alleviates gut dysbiosis and zinc dyshomeostasis during doxorubicin-induced cardiotoxicity in rats." Food & Function 10, no. 9 (2019): 5587–604. http://dx.doi.org/10.1039/c9fo01034c.

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4

Pranata, Alvin, and Reggie Surya. "Effects of The Addition of Complexing Agents on Curcumin Stability Using Accelerated Shelf Life Testing." Journal of Physics: Conference Series 2049, no. 1 (October 1, 2021): 012034. http://dx.doi.org/10.1088/1742-6596/2049/1/012034.

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Abstract Curcumin as a natural colorant product from turmeric used in food industry has low stability. Curcumin is easily oxidized due to light, oxygen, or high temperature. One of the methods that can be used to increase its stability is by complexation process using metal ions. The aim of this research are to determine product shelf life and the best complexing agent to increase curcumin stability. In this research there were three complexing agent used to form curcumin complex. Then, the stability of products are measured through curcumin concentration parameter and based on its shelf life using Accelerated Shelf Life Testing (ASLT) method. The results stated that curcumin-Zn complex exerted the highest stability against control and other complexing agent, hence the shelf life was projected to increase by 10-15 days at 35°C compared to untreated liquid curcumin. Conversely curcumin-Fe complex demonstrated the lowest shelf life due to the role of Fe as a potential oxidizing agent.

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5

Su, Hongmin, Fuxing Sun, Jiangtao Jia, Hongming He, Aifei Wang, and Guangshan Zhu. "A highly porous medical metal–organic framework constructed from bioactive curcumin." Chemical Communications 51, no. 26 (2015): 5774–77. http://dx.doi.org/10.1039/c4cc10159f.

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6

Banerjee, Rona. "Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation." Bioinorganic Chemistry and Applications 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/325873.

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Mononuclear complexes of Curcumin with Cu(II) and Zn(II) have been synthesized and, characterized and their effects on the fibrillization and aggregation of amyloid-beta (Aβ) peptide have been studied. FTIR spectroscopy and atomic force microscopy (AFM) observations demonstrate that the complexes can inhibit the transition from less structured oligomers toβ-sheet rich protofibrils which act as seeding factors for further fibrillization. The metal complexes also impart more improved inhibitory effects than Curcumin on peptide fibrillization.

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7

Du, Yu, Xiaojian Li, Xiang Ren, Huan Wang, Dan Wu, Hongmin Ma, Dawei Fan, and Qin Wei. "Signal-off electrochemiluminescence immunosensors based on the quenching effect between curcumin-conjugated Au nanoparticles encapsulated in ZIF-8 and CdS-decorated TiO2 nanobelts for insulin detection." Analyst 145, no. 5 (2020): 1858–64. http://dx.doi.org/10.1039/c9an02288k.

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8

Pucci, Daniela, Alessandra Crispini, Bárbara Sanz Mendiguchía, Sante Pirillo, Mauro Ghedini, Sabrina Morelli, and Loredana De Bartolo. "Improving the bioactivity of Zn(ii)-curcumin based complexes." Dalton Transactions 42, no. 26 (2013): 9679. http://dx.doi.org/10.1039/c3dt50513h.

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9

Shahcheraghi, Seyed Hossein, Fateme Salemi, Niloufar Peirovi, Jamshid Ayatollahi, Waqas Alam, Haroon Khan, and Luciano Saso. "Nrf2 Regulation by Curcumin: Molecular Aspects for Therapeutic Prospects." Molecules 27, no. 1 (December 28, 2021): 167. http://dx.doi.org/10.3390/molecules27010167.

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Nuclear factor erythroid 2 p45-related factor (2Nrf2) is an essential leucine zipper protein (bZIP) that is primarily located in the cytoplasm under physiological conditions. Nrf2 principally modulates endogenous defense in response to oxidative stress in the brain.In this regard, Nrf2 translocates into the nucleus and heterodimerizes with the tiny Maf or Jun proteins. It then attaches to certain DNA locations in the nucleus, such as electrophile response elements (EpRE) or antioxidant response elements (ARE), to start the transcription of cytoprotective genes. Many neoplasms have been shown to have over activated Nrf2, strongly suggesting that it is responsible for tumors with a poor prognosis. Exactly like curcumin, Zinc–curcumin Zn (II)–curc compound has been shown to induce Nrf2 activation. In the cancer cell lines analyzed, Zinc–curcumin Zn (II)–curc compound can also display anticancer effects via diverse molecular mechanisms, including markedly increasing heme oxygenase-1 (HO-1) p62/SQSTM1 and the Nrf2 protein levels along with its targets. It also strikingly decreases the levels of Nrf2 inhibitor, Kelch-like ECH-associated protein 1 (Keap1) protein.As a result, the crosstalk between p62/SQSTM1 and Nrf2 could be used to improve cancer patient response to treatments. The interconnected anti-inflammatory and antioxidative properties of curcumin resulted from its modulatory effects on Nrf2 signaling pathway have been shown to improve insulin resistance. Curcumin exerts its anti-inflammatory impact through suppressing metabolic reactions and proteins such as Keap1 that provoke inflammation and oxidation. A rational amount of curcumin-activated antioxidant Nrf2 HO-1 and Nrf2-Keap1 pathways and upregulated the modifier subunit of glutamate-cysteine ligase involved in the production of the intracellular antioxidant glutathione. Enhanced expression of glutamate-cysteine ligase, a modifier subunit (GLCM), inhibited transcription of glutamate-cysteine ligase, a catalytic subunit (GCLC). A variety of in vivo, in vitro and clinical studies has been done so far to confirm the protective role of curcumin via Nrf2 regulation. This manuscript is designed to provide a comprehensive review on the molecular aspects of curcumin and its derivatives/analogs via regulation of Nrf2 regulation.

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10

Hasan, Akhmad Endang Zainal, Mega Safithri, Aziz Syamsul Huda, and Rini Kurniasih. "IN SILICO, TO DETERMINE THE ACTIVE COMPOUNDS OF BLACK TEA AND TURMERIC IN INCREASING THE ACTIVITY OF THE ENZYME SOD." Indonesian Journal of Applied Research (IJAR) 3, no. 1 (May 12, 2022): 32–45. http://dx.doi.org/10.30997/ijar.v3i1.187.

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Damage to cells caused by stress can be reduced by the presence of antioxidants, one of which is Superoxide dismutase (SOD). The role of the active ingredients of black tea and turmeric will be studied using the in-silico method to identify the active compounds as components in SOD activation. The bioavailability and toxicity of the active compounds of black tea and turmeric were studied and followed by molecular docking and virtual games. The parameters studied are Gibbs's free energy (∆G) and binding site similarity (BSS). The results were analyzed using Gibbs's free energy (∆G) and binding site similarity (BSS) parameters. It was found that those that could increase the activity of Cu/Zn SOD enzymes were Epicatechin gallate (black tea) and curcumin (turmeric), with values of -9.5 and -7.4 Kcal/mol and the same BSS value of 81.8%. The control ligand used was beta amyrin. According to Lipinski's rules, Epicatechin gallate and curcumin compounds can be absorbed well and are safe for consumption. This study concludes that Epicatechin gallate, an active compound of black tea, and curcumin, an active compound of turmeric rhizome, have the best potential to increase the activity of Cu/Zn SOD enzymes based on the results of virtual screening and molecular docking. Epicatechin gallate and curcumin are predicted to be well absorbed by the body because they qualify Lipinski's rules and are not toxic and safe for consumption.

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