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Dissertations / Theses on the topic 'Zinc fingers'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Blancafort, Pilar. "Making conformation-specific RNA-binding zinc fingers." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0023/NQ47598.pdf.

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2

Giesecke, Astrid. "Protein-protein interactions mediated by Cys2His2 zinc-fingers." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=981809715.

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3

Isalan, Mark David. "Selection of zinc fingers with novel DNA-binding specificities." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621667.

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4

Looman, Camilla. "The ABC of KRAB zinc finger proteins." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3515.

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5

Hallal, Samantha. "Characterisation of the zinc fingers of erythroid krüppel-like factor." Connect to full text, 2008. http://ses.library.usyd.edu.au/handle/2123/4030.

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Thesis (Ph. D.)--University of Sydney, 2009.<br>Title from title screen (viewed February 10, 2009). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Molecular and Microbial Biosciences, Faculty of Science. Degree awarded 2009; thesis submitted 2008. Includes bibliographical references. Also available in print form.

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6

Hallal, Samantha. "Characterisation of the zinc fingers of Erythroid Kruppel-Like Factor." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/4030.

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Gene expression is known to be regulated at the level of transcription. Recently, however, there has been a growing realisation of the importance of gene regulation at the post-transcriptional level, namely at the level of pre-mRNA processing (5’ capping, splicing and polyadenylation), nuclear export, mRNA localisation and translation. Erythroid krüppel-like factor (Eklf) is the founding member of the Krüppel-like factor (Klf) family of transcription factors and plays an important role in erythropoiesis. In addition to its nuclear presence, Eklf was recently found to localise to the cytoplasm

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7

Hallal, Samantha. "Characterisation of the zinc fingers of Erythroid Kruppel-Like Factor." University of Sydney, 2008. http://hdl.handle.net/2123/4030.

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Doctor of Philosophy (PhD)<br>Gene expression is known to be regulated at the level of transcription. Recently, however, there has been a growing realisation of the importance of gene regulation at the post-transcriptional level, namely at the level of pre-mRNA processing (5’ capping, splicing and polyadenylation), nuclear export, mRNA localisation and translation. Erythroid krüppel-like factor (Eklf) is the founding member of the Krüppel-like factor (Klf) family of transcription factors and plays an important role in erythropoiesis. In addition to its nuclear presence, Eklf was recently found

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8

Simpson, Raina Jui Yu. "The multiple roles of zinc finger domains." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/655.

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Zinc finger (ZnF) domains are prevalent in eukaryotes and play crucial roles in mediating protein-DNA and protein-protein interactions. This Thesis focuses on the molecular details underlying interactions mediated by two ZnF domains. The GATA-1 protein is vital for the development of erythrocytes and megakaryocytes. Pertinent to the protein function is the N-terminal ZnF. In particular, this domain mediates interaction with DNA containing GATC motifs and the coactivator protein FOG. The importance of these interactions was illustrated by the findings in Chapter 3 that naturally occurring muta

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9

Simpson, Raina Jui Yu. "The multiple roles of zinc finger domains." University of Sydney. Molecular and Microbial Biosciences, 2004. http://hdl.handle.net/2123/655.

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Zinc finger (ZnF) domains are prevalent in eukaryotes and play crucial roles in mediating protein-DNA and protein-protein interactions. This Thesis focuses on the molecular details underlying interactions mediated by two ZnF domains. The GATA-1 protein is vital for the development of erythrocytes and megakaryocytes. Pertinent to the protein function is the N-terminal ZnF. In particular, this domain mediates interaction with DNA containing GATC motifs and the coactivator protein FOG. The importance of these interactions was illustrated by the findings in Chapter 3 that naturally occurring muta

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10

Garcia, Anderson. "Peptídeos derivados da proteína bacteriana YacG : síntese e estudos de estrutura-função /." Araraquara : [s.n.], 2010. http://hdl.handle.net/11449/87996.

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Resumo: YacG é uma pequena proteína (65 resíduos de aminoácidos) ligada ao zinco codificada pelo gene yacG de Escherichia coli. Seu papel fisiológico não está bem caracterizado, porém acredita-se que ela exerça ação inibitória sobre a atividade catalítica da DNA girase, enzima responsável por alterações no estado topológico do DNA bacteriano. Com base nas informações da estrutura primária desta proteína, uma série constituída de oito seqüências peptídicas foram projetadas e sintetizadas pela metodologia da fase sólida, objetivando-se avaliar e melhor entender o efeito da coordenação do íon zin

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11

Wadhwa, Vibhuti. "Biophysical approaches towards greater understanding of eukaryotic zinc sensing." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1593621283583113.

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12

Méndez, Vidal Cristina. "Molecular studies of WIG-1, A P53-induced zinc finger protein /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-732-0.

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13

Schaufler, Lawrence E. "NMR studies of the ADR1 zinc finger transcription factor /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/5079.

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14

Baxley, Ryan M. "Understanding the contribution of individual zinc fingers to a multi-functional, polydactyl transcription factor." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1290.

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Suppressor of Hairy-wing [Su(Hw)] is a twelve zinc-finger (ZF), DNA binding transcription factor. Su(Hw) has been well characterized as critical component of the gypsy insulator complex, required for the enhancer blocking and the barrier activity of the insulator. In addition to gypsy, Su(Hw) localizes to ~3,000 binding sites in the Drosophila genome, with association to a subset of sites required for female germline development. Loss of Su(Hw) results in activation of a developmental checkpoint and apoptosis at mid- oogenesis, with a critical role during oogenesis in down-regulation of neural

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15

Meagher, Madeleine Joy. "Identification and characterization of ZFR, a zinc finger protein required for murine embryonic cell survival and growth /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/10291.

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16

Hellborg, Fredrik. "Identification, cloning and characterization of the p53 induced gene human wig-1 /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-190-3/.

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17

Squillace, Rachel Marguerite. "Inhibition of muscle differentiation by the novel muscleblind-related protein CHCR /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/15468.

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18

Kwan, Ann Hau Yu. "Protein Design Based on a PHD Scaffold." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/564.

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The plant homeodomain (PHD) is a protein domain of ~45�100 residues characterised by a Cys4-His-Cys3 zinc-binding motif. When we commenced our study of the PHD in 2000, it was clear that the domain was commonly found in proteins involved in transcription. Sequence alignments indicate that while the cysteines, histidine and a few other key residues are strictly conserved, the rest of the domain varies greatly in terms of both amino acid composition and length. However, no structural information was available on the PHD and little was known about its function. We were therefore interested in det

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19

Kwan, Ann Hau Yu. "Protein Design Based on a PHD Scaffold." University of Sydney. Molecular and Microbial Biosciences, 2004. http://hdl.handle.net/2123/564.

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The plant homeodomain (PHD) is a protein domain of ~45�100 residues characterised by a Cys4-His-Cys3 zinc-binding motif. When we commenced our study of the PHD in 2000, it was clear that the domain was commonly found in proteins involved in transcription. Sequence alignments indicate that while the cysteines, histidine and a few other key residues are strictly conserved, the rest of the domain varies greatly in terms of both amino acid composition and length. However, no structural information was available on the PHD and little was known about its function. We were therefore interested in det

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20

Blottière, Louise. "Etude des genes ozf (only zinc fingers) humain et murin : incidence dans les cancers du sein." Paris 6, 1999. http://www.theses.fr/1999PA066064.

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Ces travaux concernent l'isolement et l'etude des genes murins mozf et zfp260. Le premier est l'homologue murin du gene humain hozf (only zinc fingers), surexprime dans des cancers du pancreas. Le second code une proteine identique a 81% a la proteine mozf et dotee d'un domaine supplementaire. Ces genes participeraient a l'initiation ou a la progression tumorale. Le gene hozf, localise en 19q13. 1, a une expression non ubiquitaire. Il est amplifie dans 15 a 25% des lignees cellulaires et tumeurs du pancreas exocrine analysees, et surexprime en arnm et en proteine dans plus de 50% des cas. La p

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21

Drolet, Jessica Ann. "Evidence for the involvement of the zinc cluster protein Asg1p in the transcriptional regulation of some stress response genes in Saccharomyces cerevisiae." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112617.

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Saccharomyces cerevisiae has developed mechanisms in order to survive harsh environmental conditions. This species responds to stresses such as ethanol, heat, and weak acid exposure via two well-characterized stress response pathways. These typically involve either the Hsf1p or the Msn2/4p transcriptional regulators. Recently, our lab has begun to characterize a member of the zinc cluster protein family: Asg1p (Activator of Stress Genes, systematic name: YIL130W), which is presumed to stimulate stress response genes independently of the Hsflp and Msn2/4p pathways. Previous work has revealed fi

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22

Rao, Harita. "Metal containing peptides as specific DNA binders." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://hdl.handle.net/11858/00-1735-0000-0028-86AC-9.

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23

Nail, Alexandra Nichole. "EVOLUTION OF THE ZHX TRANSCRIPTION FACTOR FAMILY AND ANALYSIS OF ZHX2 TARGET GENES CYP2A4 AND CYP2A5 IN MOUSE LIVER." UKnowledge, 2019. https://uknowledge.uky.edu/microbio_etds/20.

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The liver is the largest internal organ and performs a wide variety of functions to maintain organismal homeostasis. While some liver functions are carried out by all hepatocytes, other functions are restricted to certain populations of hepatocytes within the liver. This phenomenon, called zonal gene regulation or liver zonation, controls may metabolic processes within the liver including ammonia detoxification; glucose homeostasis; bile acid and glutamine synthesis; and metabolism of xenobiotics, lipids, and amino acids. The liver also expresses many genes in a developmental or sex-biased man

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24

Gupta, Ankit. "Getting a Tight Grip on DNA: Optimizing Zinc Fingers for Efficient ZFN-Mediated Gene Editing: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/637.

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The utility of a model organism for studying biological processes is closely tied to its amenability to genome manipulation. Although tools for targeted genome engineering in mice have been available since 1987, most organisms including zebrafish have lacked efficient reverse genetic tools, which has stymied their broad implementation as a model system to study biological processes. The development of zinc finger nucleases (ZFNs) that can create double-strand breaks at desired sites in a genome has provided a universal platform for targeted genome modification. ZFNs are artificial restriction

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25

Garcia, Anderson [UNESP]. "Peptídeos derivados da proteína bacteriana YacG : síntese e estudos de estrutura-função." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/87996.

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Made available in DSpace on 2014-06-11T19:23:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-12-03Bitstream added on 2014-06-13T19:49:45Z : No. of bitstreams: 1 garcia_a_me_araiq.pdf: 1326845 bytes, checksum: c851f7e719ab97b784e7423d4226e61b (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>YacG é uma pequena proteína (65 resíduos de aminoácidos) ligada ao zinco codificada pelo gene yacG de Escherichia coli. Seu papel fisiológico não está bem caracterizado, porém acredita-se que ela exerça ação inibitória sobre a atividade catalítica da DNA girase, enz

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26

Schmiedeskamp, Mia Ruth. "NMR studies of the DNA-binding domain of ADR1 /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/9208.

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27

Frank, Deborah Jean. "Regulation of cell growth in C. elegans and D. melanogaster by ncl-1/brat /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/5029.

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28

Patel, Reena. "Mediation of pleiotropic drug resistance by zinc cluster transcriptional regulators in Saccharomyces cerevisiae." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:8881/R/?func=dbin-jump-full&object_id=32366.

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29

Spell, Sarah. "The Study of Au(III) Compounds and their Interaction with Zinc Finger Proteins." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/634.

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Gold compounds have been used in medicine dating back as early as 2500 BC. Over the years gold(I) and gold(III) compounds have been used and designed to target rheumatoid arthritis, cancer, and viral diseases. New drug targets have been found for gold compounds that give insight into their mechanisms of action. Here we focus on the synthesis of Au(III) compounds designed to selectively target zinc finger (ZF) proteins. ZF proteins exhibit a variety of functions, including transcription, DNA repair, and apoptosis. Displacement of the central zinc ion, along with mutation of coordinated amino ac

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30

Szkudlarek-Mikho, Maria. "Characterizing the function of extracellular protein kinase A in angiogenesis and the effects of Zfp68 and pharmacological inibitors in adipogenesis." Toledo, Ohio : University of Toledo, 2010. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1270565982.

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Dissertation (Ph.D.)--University of Toledo, 2010.<br>"Submitted to the Graduate Faculty as partial fulfillment of the requirements for the Doctor of Philosophy Degree in Biomedical Science." Title from title page of PDF document. "A Dissertation entitled"--at head of title. Bibliography: p. 54-56, 81-82, 113-128.

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31

Zhou, Shengli. "ZNF451 is a novel binding partner of the bHLH transcription factor E₁₂." Connect to full text in OhioLINK ETD Center, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1225219996.

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Thesis (M.S.)--University of Toledo, 2008.<br>"In partial fulfillment of the requirements for the degree of Master of Science in Biomedical Sciences." Title from title page of PDF document. Bibliography: pages 49-62.

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32

Parker, Tory L. "The Effects of Selenium on Estrogen-regulated Gene Expression in LNCaP Prostate Cancer Cells." BYU ScholarsArchive, 2004. https://scholarsarchive.byu.edu/etd/637.

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Prostate cancer is the most frequently diagnosed cancer in American men and the second leading cause of cancer deaths. Supplementation with Se has reduced the incidence of prostate cancer and Se status is inversely correlated with prostate cancer risk. One molecular mechanism by which high Se concentrations may affect cancer risk is by catalyzing disulfide bond formation or otherwise complexing with reactive sulfhydryl groups in cellular proteins. The estrogen receptor (ER) contains cysteines in zinc (Zn) fingers that are susceptible to oxidation and internal disulfide formation, which can pre

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33

Lebrun, Vincent. "Doigts de zinc et stress oxydant : réactivité vis-à-vis de l'oxygène singulet et l'acide hypochloreux." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV068/document.

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Très répandues dans le monde vivant, les protéines à doigt de zinc constituent une super-famille dont les membres possèdent un site à zinc de formule générale [ZnII(Cys)4-X(His)X] (x=0, 1 or 2). Tandis que la majorité de ces sites joue un rôle purement structural, certains présentent une fonction réactive, comme la détection de stress oxydant par exemple. En effet, les sites doigt de zinc de Hsp33 et de RsrA ont été décrits comme des interrupteurs rédox[1,2] : transmettant l'information « stress oxydant » sous forme d'un signal structural, via l'oxydation/réduction des cystéines coordonnées au

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34

Runko, Alexander Peter. "Function of the Zinc-Finger Repressor NLZ in the Developing Zebrafish Hindbrain: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/74.

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Generation of the primitive neuroectoderm into specialized brain subdivisions, such as the hindbrain primordium, involves the regulated coordination of complex morphogenetic and molecular mechanisms. These processes are evident in the segregation of the zebrafish hindbrain into seven distinct lineage-restricted compartments, termed rhombomeres (r), which are established by the interplay of several spatially-restricted expressed genes. These include transcription factors, members of specific signaling pathways and specialized molecules that mediate cell adhesion and identity. Despite their exte

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35

Purcell, Jamie, and Jamie Purcell. "Investigating the RNA Binding Domains of MBNL1 and the Alternative Splicing Motifs They Recognize." Thesis, University of Oregon, 2012. http://hdl.handle.net/1794/12331.

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Muscleblind-like 1 (MBNL1) is a ubiquitously expressed RNA binding protein that regulates the alternative splicing of a variety of transcripts. In Myotonic Dystrophy (DM) aberrant cellular localization of MBNL1 results in disease-associated mis-splicing of several MBNL1 target pre-mRNAs. Due to its role in DM pathogenesis, MBNL1 has been a topic of intense study for the last decade, however many open mechanistic questions remain regarding how MBNL1 recognizes RNA substrates to mediate splicing. The RNA recognition motif for MBNL1, 5'-YGCY-3', was defined herein. This motif was used to ide

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36

Frémy, Guillaume. "Synthèse de sondes luminescentes pour la détection séquence spécifique d'ADN double brin." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAV073.

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L’ADN est le support de l’information de tout être vivant. La possibilité de pouvoir cibler et visualiser in vivo une séquence spécifique d’ADN et plus particulièrement un gène est un enjeu de taille pour le suivi médical aussi bien que pour la compréhension du vivant. Pour y parvenir, la détection par luminescence est particulièrement attrayante de par sa facilité de visualisation avec des outils simples.L’objet de cette thèse était d’apporter la preuve de concept de sondes luminescentes pour la détection séquence spécifique d’ADN double brin, basées d’une part sur les propriétés de luminesce

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37

Wilhelm, Margareta. "The p53-induced gene wig-1 : regulation of expression and role in embryonic development /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-728-2.

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38

Deveau, Laura M. "Characterizing the Disorder in Tristetraprolin and its Contribution to Post-Transcriptional Gene Regulation: A Dissertation." eScholarship@UMMS, 2016. http://escholarship.umassmed.edu/gsbs_diss/855.

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RNA-binding proteins (RBPs) are important for a wide variety of biological processes involved in gene regulation. However, the structural and dynamic contributions to their biological activity are poorly understood. The tristetraprolin (TTP) family of RBPs, including TTP, TIS11b and TIS11d, regulate the stability of mRNA transcripts encoding for key cancer-related proteins, such as tumor necrosis factor- and vascular endothelial growth factor. Biophysical studies have shown that the RNA binding domain, consisting of two CCCH zinc fingers (ZFs), is folded in the absence of RNA in TIS11d and TI

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39

Heath, Megan Joy. "Human immunodeficiency virus nucleocapsid protein analysis of the mechanism of strand exchange and the role of the zinc fingers in nucleic acid chaperone activity /." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/1690.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2004.<br>Thesis research directed by: Molecular and Cell Biology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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40

Wilson, Stevin. "Understanding Zinc Homeostasis using Loz1 from the Fission Yeast." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1565902886663748.

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41

Jacques, Aurélie. "Interaction de l'or avec des peptides modèles de doigts de zinc : caractérisation de la complexation des sels d'or et application à la toxicologie des nanoparticules d'or." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV075/document.

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Les complexes d'or(I) tels que l'auranofine et l'aurothiomalate ont été utilisés dans le traitement de la polyarthrite rhumatoïde depuis plusieurs décennies. Plus récemment, de nombreux complexes d'or(I) et d'or(III) ont révélé des activités anti-cancéreuses in vitro importantes. Cependant, du fait de la forte affinité de l'or pour les thiols et les sélénols, ces complexes interagissent dans les cellules avec de nombreuses protéines de façon non spécifique. Ce qui explique les effets secondaires observés chez les patients soumis à des traitements prolongés de chrysothérapie et rend plus diffic

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42

Creasy, Kate Townsend. "ZHX2 REGULATION OF LIPID METABOLISM AND THE BALANCE BETWEEN CARDIOVASCULAR AND HEPATIC HEALTH." UKnowledge, 2015. http://uknowledge.uky.edu/pharmacol_etds/10.

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The growing obesity epidemic in America carries with it numerous health risks, including diabetes, increased serum lipid levels, and excess fat accumulation in the liver. If these conditions persist or become exacerbated, they may lead to the development of cardiovascular disease, the current leading cause of death among Americans, or to nonalcoholic fatty liver disease (NAFLD) which can progress to hepatocellular carcinoma (HCC), one of the deadliest forms of cancer. Better understanding of the genes involved in these diseases can lead to improved identification of at-risk individuals and tre

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43

Tucker, Sean Newton. "Ikaros affects the expression of the interleukin-2 receptor beta chain and lymphoid cell potential /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8338.

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Bessa, Danielle de Souza. "Análise de metilação global em pacientes com puberdade precoce central familial." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-31102018-120553/.

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A idade normal para início da puberdade em meninas varia bastante, de 8 a 13 anos, e os genes envolvidos nesse controle são parcialmente conhecidos. Fatores ambientais, como alimentação e exposição a disruptores endócrinos, contribuem para essa variabilidade, de modo que genes modulados epigeneticamente podem justificar parte da complexidade desse processo. O termo epigenética se refere às modificações na expressão gênica que não são causadas por alterações na sequência do DNA. A metilação do DNA é o mecanismo epigenético mais bem estudado. Na última década surgiram evidências demonstrando a r

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45

Harris, John E. "The Molecular Mechanisms of T Cell Clonal Anergy: A Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/6.

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A side effect of generating an immune system for defense against invading pathogens is the potential to develop destructive cells that recognize self-tissues. Typically, through the "education" of developing immune cells, the organism inactivates potentially self-destructive cells, resulting in what is called self-tolerance. I proposed to explore the molecular mechanisms responsible for the induction and maintenance of tolerance. Our lab has developed a model of induced immune tolerance to skin and islet allografts utilizing a donor-specific transfusion of spleen cells and a brief course of an

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46

Valsecchi, Isabel. "AtZDP, a Plant 3' DNA Phosphatase, Involved in DNA Repair." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8907.

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47

Valeije, Ana Claudia Mancusi. "Utilização de informações termodinâmicas e estruturais na predição de sítios de ligação de receptores nucleares ao DNA: uma abordagem computacional." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-23042015-133407/.

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Os projetos genoma têm fornecido uma grande quantidade de informação sobre a arquitetura gênica e sobre a configuração física de suas respectivas regiões flanqueadoras (RF). Estas RF contêm informações com o potencial de auxiliar na elucidação de vários processos biológicos, como os mecanismos de expressão gênica e de sua regulação. Estes mecanismos são de extrema importância para a compreensão do correto funcionamento dos organismos e das patologias que os afetam. Uma parte significativa dos mecanismos de controle de expressão gênica atuam na fase transcricional. Na base destes mecanismos est

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48

Lanfear, Jeremy. "The molecular evolution of zinc-finger genes." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291274.

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49

Crawford, Catherine. "Characterisation of endogenous KRAB zinc finger proteins." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4225.

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The Krüppel-associated box (KRAB) zinc finger protein (ZFP) genes comprise one of the largest gene families in the mammalian genome, encoding transcription factors with an N-terminal KRAB domain and C-terminal zinc fingers. The KRAB domain interacts with a co-repressor protein, KAP-1, which can recruit various factors causing transcriptional repression of genes to which KRAB ZFPs bind. Little is currently known about the gene targets of the ~400 human and mouse KRAB ZFPs. Many KRAB ZFPs interact with factors other than KAP-1. To identify proteins that may interact with one particular KRAB ZFP

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Rebar, Edward John. "Selection studies of zinc finger-DNA recognition." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/10383.

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